Abstract
OD1
CLINICAL PREDICTIVE FACTORS FOR ALL-CAUSE MORTALITY AND RENAL FUNCTION DETERIORATION IN TYPE2 DIABETIC PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE 3 CHIPIN-PING CHEN, SZU-TAH CHEN, CHUNG-HUEI HUANG Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Taiwan, R.O.C.
To explore the factors predicting all-cause mortality and renal function deterioration in Type2 diabetic patients with chronic kidney disease stage 3(CKD3). METHODS: We collected 850 Type2 diabetic patients who joined in shared care with CKD3 from 2010 January 1 to December 31, 2017. The prospective cohort data from the north medical center, and the deadline of the follow-up was December 31, 2017. Survival analysis was performed by Kaplan- Meier method. Cox proportional hazards regression model was used to assess the all- cause mortality after adjustment for confounding factors. RESULTS: The average age of the subjects was 68.27 ± 10.20 years. During the seven-years follow-up period, 66 (7.8%) patients dialysis and 130(15.3%) patients died. Results of Cox regression model showed thatthe progression of dialysis risk in the Type 2 diabetic patients with CKD3 were the EDVHOLQH H*)5 +5 &, WKH ¿UVW \HDU GHFOLQH H*)5 +5 &, 1.15), CKD3duration (HR = 1.11, 95% CI:1.00-1.24), age (HR = 0.97, 95% CI:0.94-0.99) and baseline retinopathy (HR = 2.39, 95% CI:1.14-5.01).The all-cause mortality risk in the Type 2 diabetic patients with CKD3werethe second year decline eGFR (HR = 1.03, 95% CI:1.01-1.06), and age (HR = 1.09, 95% CI:1.06-1.123).CONCLUSION: We should focus on the prevention and treatment of the Type 2 diabetic patients with CKD3in order to attenuate progression of renal dysfunction and mortality.
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