NEW FROM GARLAND SCIENCE
PETER LYDYARD Royal Free and University College Medical School, UK MICHAEL COLE Georgetown University Medical Center, USA JOHN HOLTON Royal Free and University College Medical School, UK WILLIAM IRVING University of Nottingham School of Medicine, UK
Case Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine, this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis and treatment. The use of real clinical cases serves to reinforce and extend the basic science.
NINO PORAKISHVILI University of Westminster School of Biosciences, UK
Following the description of each case history, the same five sets of core questions are asked to encourage the student to think about infections in a common sequence. The initial set concerns the nature of the infectious agent, how the agent gains access to the body, what cells are infected, and how the organism spreads; the second set asks about host defense mechanisms against the agent and how disease is caused; the third set inquires about the clinical manifestations of the infection and the complications that can occur; the fourth set is related to how the infection is diagnosed, and what is the differential diagnosis, and the final set asks how the infection is managed, and what preventative measures can be taken to avoid the infection.
“Scientifically, the chapter is accurate… the figures have been well chosen and they will help the reader to grasp the main points more readily. It was a pleasure reviewing this material…”
A
C
B Helicobacter pylori
gastric mucus
protective mucus
D increased acid secretion
bleeding ulcer
duodenal ulcer corpus
inflammation
pylorus inflammatory cells
stomach
gastric ulcer duodenum
antrum
infection H. pylori infects the lower part of the stomach, antrum case studies in infectious disease | Helicobacter pylori | figure 06
inflammation H. pylori causes inflammation of the gastric mucosa (gastritis), this is often asymptomatic
ulcer gastric inflammation may lead to duodenal or gastric ulcer, severe complications include bleeding ulcer and perforated ulcer
inflammation
Figure 12.6. General scheme of infection with H. pylori leading to development of a peptic ulcer. © www.garlandscience.com design by www.blink.biz
PRADHIB VENKATESAN Nottingham City Hospital, UK KATE WARD Royal Free and University College Medical School, UK
Dr. Juerg Utzinger, Swiss Tropical Institute, Switzerland (referring to Case 32. Schistosoma)
“I like the use of questions to deliver teaching to students. They can easily identify with what is being discussed and how it fits in with the overall chapter. It can also quickly direct learning to the appropriate part of the text and aid revision.” Dr. Gordon Ramage, Glasgow Caledonian University, UK (referring to Case 1. Aspergillus fumigatus)
Garland Science l May 2009 l 60 Paperback: 978-0-8
p17 matrix protein lipid bilayer from host
p24 core protein
gp120 envelope protein
Key Features l The 270 full-color illustrations are available in JPEG and PowerPointÂŽ format at: www.garlandscience.com/gs_textbooks.asp
host protein
gp41 envelope protein reverse single-stranded transcriptase HIV-1 RNA
case studies in infectious disease | HIV | figure 04
Figure 17.4. The structure of HIV. design by www.blink.biz Š www.garlandscience.com
l In the contents section, diseases are listed alphabetically under the causative agent. A separate table categorizes the pathogens as bacteria, viral, protozoal/worm/fungal and acts as a guide to the relative involvement of each body system affected. l Each case answers five core questions and concludes with a bullet-point summary of these same key questions: v What is the causative agent, how does it enter the body, and how does it spread within the body and from person to person? v What is the host response and what is the disease pathogenesis? v What is the typical clinical presentation and what complications can occur? v How is the disease diagnosed, and what is the differential diagnosis? v How is it managed and prevented?
Figure 16.1. Chest radiograph of the patient infected with H. capsulatum revealing bilateral nodular infiltrates.
08 pages l 270 full-color illustrations 8153-4142-0: ÂŁ33.00
l Each case has multiple-choice questions for self-testing with the answers given in the back of the book. Each case ends with a complete set of references, suggestions for further reading, and a list of relevant websites. l A comprehensive glossary allows rapid access to the microbiology and medical terms highlighted in bold in the text.
Table of Contents
Case 1. Aspergillus fumigatus Case 2. Borellia burgdorferi Case 3. Campylobacter jejuni Case 4. Chlamydia trachomatis Case 5. Clostridium difficile Case 6. Coxiella burnetti Case 7. Coxsackie B virus Case 8. Echinococcus spp. Case 9. Epstein-Barr virus Case 10. Escherichia coli Case 11. Giardia lamblia Case 12. Helicobacter pylori Case 13. Hepatitis B virus Case 14. Herpes simplex type 1 (HSV 1) Case 15. Herpes simplex type 2 (HSV 2) Case 16. Histoplasma capsulatum Case 17. Human immunodeficiency virus (HIV) Case 18. Influenza virus Case 19. Leishmania Case 20. Leptospira Case 21. Listeria monocytogenes Case 22. Mycobacterium leprae Case 23. Mycobacterium tuburculosis Case 24. Neisseria gonorrhoea Case 25. Neisseria meningitides Case 26. Norovirus Case 27. Parvovirus Case 28. Plasmodium Case 29. Respiratory syncytial virus (RSV) Case 30. Rickettsia spp. Case 31. Salmonella typhi Case 32. Schistosoma Case 33. Staphlococcus aureus Case 34. Streptococcus mitis Case 35. Streptococcus pneumoniae Case 36. Streptococcus pyogenes Case 37. Toxoplasma Case 38. Trypanosoma Case 39. Varicella Zoster virus Case 40. Wuchereria
ALSO OF INTEREST
Janeway’s Immunobiology, Seventh Edition Kenneth M. Murphy, Paul Travers and Mark Walport 2008 l 928 pages Paperback: 978-0-8153-4123-9: £46.00 Packaged with a CD-ROM
Case Studies in Immunology, Fifth Edition Raif Geha and Fred Rosen 2007 l 328 pages Paperback: 978-0-8153-4145-1: £33.00
The Immune System, Third Edition Peter Parham 2009 l 608 pages Paperback: 978-0-8153-4146-8: £41.00
www.garlandscience.com