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Fields, Forces, and Flows in Biological Systems ALAN J. GRODZINSKY Fields, Forces, and Flows in Biological Systems describes the fundamental driving forces for mass transport, electric current, and fluid flow as they apply to the biology and biophysics of molecules, cells, tissues, and organs. Basic mathematical and engineering tools are presented in the context of biology and physiology. The chapters are structured in a framework that moves across length scales from molecules to membranes to tissues. Examples throughout the text deal with applications involving specific biological tissues, cells, and macromolecules. In addition, a variety of applications focus on sensors, actuators, diagnostics, and microphysical measurement devices (e.g., bioMEMs/NEMs microfluidic devices) in which transport and electrokinetic interactions are critical. This textbook is written for advanced undergraduate and graduate students in biological and biomedical engineering and will be a valuable resource for interdisciplinary researchers including biophysicists, physical chemists, materials scientists, and chemical, electrical, and mechanical engineers seeking a common language on the subject.
Figure 4.10 Concentric cylindrical electrode configuration of depth L into plane filled with fluid of conductivity σ2 and dielectric constant ε2⋅
Contents 1. Chemical Transport in Electrolyte Media 2. Electric Fields and Flows in Electrolyte Media 3. Electrochemical Coupling and Transport 4. Electrical Interaction Forces: From Intramolecular to Macroscopic 5. Newtonian Fluid Mechanics 6. Electrokinetics: MEMs, NEMs, and Nano-porous Biological Tissues 7. Rheology of Hydrated Biological Tissues and Polymeric Biomaterials A sample chapter and the complete set of figures from the book in JPEG format are available at www.garlandscience.com/fff.
The Author Alan J. Grodzinsky is Professor of Biological, Electrical, and Mechanical Engineering and Director of the Center for Biomedical Engineering at the Massachusetts Institute of Technology. He graduated in electrical engineering from MIT in 1971, obtaining a doctorate three years later under the supervision of James Melcher, with a thesis on membrane electromechanics. His research involves the synthesis of electrical, mechanical, and chemical processes in cells and molecular networks that help to elucidate tissue disease, remodeling, and repair. He was president of the Orthopedic Research Society from 2007-8 and has served as Chairman of the Gordon Research Conference on Bioengineering and Orthopedic Science, President of the International Cartilage Repair Society, and Chairman of the Advisory Board for the Cleveland Clinic’s Department of Biomedical Engineering. Dr. Grodzinsky has received the Goodwin Medal (MIT), an NIH Merit Award, the Kappa Delta Award from the American Academy of Orthopedic Surgeons, and was a Founding Fellow of the American Institute of Medical and Biological Engineering.
January 2011 500 pages 200 illustrations Hardcover: 978-0-8153-4212-0 £49.00
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