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KEY FEATURES
ONLINE RESOURCES
Online resources for students and instructors can be found at www.garlandscience.com/bioorganic-chembio
• Integration of mechanistic arrow-pushing into the study of molecular and cellular biology. • Chapters begin with a list of Learning Objectives and
For qualified instructors: • Artwork in JPEG & PPT® formats. • Solutions to all end-of-chapter problems.
end with Learning Outcomes. • More than 320 problems located throughout the text, with more challenging problems at the ends of
For students: • Online flashcards and glossary. • Solutions to in-text problems and selected end-of-chapter problems. • Further Reading for each chapter.
chapters. Selected solutions available to students. • Illustrations use colors pedagogically to convey additional biochemical information about biooligomers. Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology.
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Introduction to Bioorganic Chemistry and Chemical Biology | A6050 Van Vranken & Weissactivation. | 978-0-8153-4214-4 Figure 6.50 Caspase © www.garlandscience.com design by www.blink.biz
Fundamentals of Chemical Biology The Chemical Origins of Biology DNA RNA Peptides and Proteins: Structure Protein Function Glycobiology Terpenes and Polyketides Signal Transduction
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A sample chapter and detailed table Introduction to Bioorganic Chemistry and Chemical Biology | A8005 of contents are available at Figure 8.5 Thiol ester exchange mechanism for the transfer of acyl groups to Van Vranken & Weiss | 978-0-8153-4214-4 cysteine side chains www.garlandscience.com/bioorganic-chembio © www.garlandscience.com design by www.blink.biz CUSTOM PUBLISHING: Garland Science Custom Publishing enables the creation of materials from multiple sources, including Introduction to Bioorganic Chemistry and Chemical Biology, in just a few clicks. To learn more visit: http://garland.sharedbook.com UK Version.indd 2-3
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Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science. January 2013 • £48.00 • Paperback: 978-0-8153-4214-4 468 pages • 547 illustrations • 378 chemical structures
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THE AUTHORS David Van Vranken earned his BS in Chemistry from the University of Texas at Austin and his PhD in Chemistry from Stanford University before carrying out postdoctoral studies as an NSF Postdoctoral Fellow at Berkeley. In 1994, he joined the faculty at University of California, Irvine, where carrying out research that focuses on chemical structure and reactivity in peptides, bioactive natural products, and transition metal catalyzed reactions. Gregory Weiss earned undergraduate and graduate degrees from University of California, Berkeley, and Harvard, respectively. Awarded a NIH Ruth Kirschstein National Research Service Award, he pursued post-doctoral studies at Genentech. In 2000, he joined the faculty at University of California, Irvine, where his laboratory focuses on the interface between chemistry and biology, including combinatorial chemistry applied to anti-viral drug discovery, membrane proteins, and bioelectronics.
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Praise for Introduction to Bioorganic Chemistry and Chemical Biology “I would wholeheartedly support this approach to the teaching of biological chemistry. Many of the traditional textbooks present biochemical pathways in a way that encourages rote learning without developing any understanding of the reactions in terms of atoms, bonds and mechanistic organic chemistry. This book appears to be different, and it is refreshing to see many chemical structures and curly arrow pushing mechanisms.” - James Redman, Cardiff University, UK
“This is a very well written and informative book. I liked the way in which the material was presented in each chapter, and the fact that the chapters contained a lot of up-to-date material.” - Ali Tavassoli, University of Southampton , UK
“… I like the textbook. I truly like the [end-of-chapter questions] as they help [students] to reflect on the different topics. These are exactly the right questions they have to know how to answer.” - Annette G. Beck-Sickinger, Leipzig University , Germany
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ISBN: 978-0-418-26868-1
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