IN THIS SPECIAL issue we address the global concern regarding climate change, revisiting the last COP25 Climate Summit that took place in Madrid and drawing its main conclusions from the perspective of the Chilean and Spanish Governments. After that, we immerse ourselves in an exciting essay from the prestigious SciencesPo school about the new Geopolitics of Climate Governance and how it will affect the years to come. Finally, as the highlight of this special issue we offer our readers an essay by Dr. Loembe about the often forgotten link between cancer and Climate Change. And now we invite you to take a deeper look at Climate Change and its effects.