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welcome Health and longevity, In today's world of "sound bites" and the realization in our media-focused world of Andy Warhol's 15-minutes of fame for all, the term "antiaging" can encompass a wide diversity of ideas to many different people.

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For some it means beautification - especially skin antiaging. For others it has a far wider meaning - being able to escape aging's various debilitating guises, and to remain lucid, agile and independent for as long as possible. Some may only be interested in specific areas of physical or mental improvement, and then there are those w h o s e goal is longevity and life extension itself.

History teaches us that the social and medical changes that have already happened from sanitation and clean water to antibiotics and some forms of surgery - have not only benefited in their o w n way, but they have also been major contributors to extending life span. As antiaging medicine is the ultimate preventative medicine, seeking to slow, allay and inhibit the problems of old age, could add vital years to life and therefore is also likely to improve our longevity, both as individuals and as a species.

For those serious about life extension, longevity is the goal of antiaging medicine.

However, I suspect for the majority of people, it is just to improve or maintain a good level of health and performance for as long as possible. This is often referred to as the "optimal health span."

This issue of antiaging magazine is all about the optimal health span - 1 hope you find it of interest and use.

Phil M i c a n s Editor-in-chief

Declaration The Anti-Aging Magazine focuses on the latest international nutritional, hormonal and drug therapies that show promise in combating the signs of aging. T h e s e signs include the physical, mental and internal changes consisting of the diseases and disorders that include cancer, arthritis and senile dementia etc. However, the main focus is upon prevention of such aging diseases and disorders for the "healthy-aging" individual.

Copyright IAS 2005.

All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for inaccuracies, howsoever caused. No liability can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents. All information is correct at time of going to print. Not for public broadcast or copy without written permission from IAS Ltd. Terms and conditions may change without notice.

in this issue Biochemist James South reminds us about the lifework of Professor Joseph Knoll with deprenyl and his theories that the control centers of aging lie in the brain. We learn that animal experiments show that optimal heath and life span can be increased.

Pharmacologist Phil Micans overviews the role of glycosylation, or protein cross-linking in aging. These impaired molecules inhibit cell function and come a close second to free radicals in their ability to wreak havoc. But inhibitors such as aminoguanidine do exist.

Robert Mason, Ph.D. looks at a new breed of stimulants called Eugeroics. Described as being as "Safe as Caffeine, Strong as Amphetamine". Mason explains how they work and discusses the qualities that make these substances unique.

Disclaimer: The information is offered under the IAS terms and conditions and is for educational purposes only and should not replace the advice of your personal physician.

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International Antiaging Magazine is published quarterly and distributed in the USA by SPP, PO Box 437, Emigsville, PA. Application to mail at periodicals mailing rates is pending at Manchester, PA. Postmaster: send address changes to International Antiaging, c/o PO Box 437, Emigsville, PA 17318-0437

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Graphic Designer Nick James Staff Writers Chris Jameson Sonya Hardcastle Editorial Enquiries Jim Skinner Published by International Antiaging Systems Ltd, Beckett House, 14 Billing Road, Northampton, NN1 5AW, Great Britain e-mail editor@antiaging-magazine.com Subscription Enquiries subscription@antiaging-systems.com Antiaging Magazine is published quarterly by IAS Annual subscription UK ÂŁ19.80 Europe â‚Ź31.80 Rest of the world $39.80

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contributors Heather Bird With experience in health care and a Masters of Business Administration degree, Heather has worked for the World Health Organization. She founded her company HB Health in 2001. Her mission is to make the life-enhancing medical breakthroughs available to as many people as possible. This commitment resulted from her own experiences of working in nursing homes, caring for people suffering from age-related diseases like Parkinson's and Alzheimer's. HB Health co-sponsored the 3rd Annual Monte Carlo Anti-ageing Conference and sponsor the London Anti Ageing Conference.

Marios Kyriazis M.D. Marios Kyriazis is one of the few anti-aging physicians in the UK. He has a postgraduate qualification in Gerontology from the King's College, University of London, as well as a postgraduate qualification in Geriatric medicine granted by the Royal College of Physicians. He has written extensively on longevity, healthy aging and anti-aging matters for both scientists and the general public. He is a founder member and medical advisor to the British Longevity Society.

Robert Mason Ph.D. Robert Mason Ph.D., was schooled in information technology and realized the potential for research in the (then) coming information revolution. Family health concerns and a knowledge of international research taught him many "lessons." The result was an organization conducting global database research. Dr. Mason believes that aging is a disease and will be curable. Dr. Mason relies entirely on scientific/ clinical information at his disposal to form an opinion, as such he "tells-it-like-it-is!"

Marios Kyriazis, M.D. looks at the changing face of skin aging, in particular how and why skin aging problems and issues occur. Dr. Kyriazis also highlights the clinical evidence behind several substances that are proven to slow and reverse the signs of skin aging.

Phil Micans, PharmB

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Phil Micans PharmB, has degrees in Food and Vitamin Technology and Pharmacology and after reading Pearson and Shaw's book- Life Extension in 1986 has been actively involved in anti-aging medicine.

Chairman to the International Anti-Aging Conference and co-writer of the New Millennium Guide to Anti-Aging Medicine. He also maintains the position of Vice President and Director of Research and Development at International Antiaging Systems.

James South MA James South MA, is a renowned biochemist who is highly respected for his incredible knowledge of brain chemistry and nutrition. With over 30 years of experience with smart-drugs and nutrients he is a true expert. He is also the author of numerous articles and reviews and can often be heard on radio talk-shows. Furthermore he has been responsible for many of the leading nutritional formulations in the United States.

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Extending

Optimal Healthspan with Oeprenyl

By James South, MA

Deprenyl is a drug that was discovered around 1964 by Dr. Joseph Knoll and colleagues, originally developed as a "psychic energizer." Also known as L-deprenyl and selegiline, it has been intensively researched over the past 40 years with many hundreds of research papers having been published. When reviewing them, it becomes apparent that deprenyl has a unique and exciting profile. It is the only potent, selective MAO-B inhibitor in medical use, plus it is a "catecholamine activity enhancer."

In addition, deprenyl has been shown to protect nerve cells against a wide range of neurotoxins, and to act as a "neuroprotection agent" when nerve cells are exposed to damaging or stressful conditions.

Today, deprenyl is a recognised treatment for Parkinson's disease, but is also useful in treating depression. In aged animals, deprenyl has proven to be a highly effective "sexual rejuvenator" and also shows promise as a cognitive enhancement agent.

Deprenyl has been proven, in four different rodent studies, and one dog study, to be a remarkable life-extension agent.

UNIQUE ACTIVITY It was in 1971 when Dr. Knoll showed that deprenyl was a unique kind of MAO inhibitor— specifically a selective MAO-B inhibitor, without any "cheese effect." Effectively by inhibiting this enzyme, deprenyl can increase the brain's levels of dopamine, and while some authors have questioned deprenyl's ability to increase dopamine levels by this method alone, it wasn't until the 1990s that Dr. Knoll discovered the "main basis" of deprenyl's action.

Jozeph Knoll, M.D., PharmD., is the Professor of Pharmacology at the University of Semmelweiss, in Hungary. His long career has seen him achieve numerous innovative medical and pharmaceutical breakthroughs,

Deprenyl is one of the mainstays and still one of the most important drugs used in Antiaging Medicine today. It has been shown to have a wide diversity of uses, including slowing and treating the prevalence of dementia (in particular Parkinson's and Alzheimer's Disease), and is also a potent anti-depressive, as well as a libido enhancing agent. Furthermore, it has significantly increased the life span of animals. How can one substance have such a wide diversity of effects?

This article attempts to highlight the actions and issues surrounding deprenyl and details some of its uses 4

including the development of tests for pharmacological analysis of tranquillizers and psychostimulants. Plus his analysis of the physiological basis of drive-motivated behavior created new analgesic antiinflammatory drug groups. In the 1960s he was a key-player in the development of deprenyl. His experiments have shown it to slow the age-related decline of sexual and learning performance and prolong life.

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ATTENTION, DEPRESSION, LIFE SPAN AND THE CATECHOLAMINES During the 1990s Dr. Knoll uncovered a new mode of action of deprenyi that he believes explains its widespread clinical utility. He discovered that deprenyi (and its "cousin"phenylethylamine) are "catecholamine activity enhancers."

Catecholamines refer to the inter-related neurotransmitters of dopamine, noradrenaline and adrenaline. These transmitters activate key brain circuits helping to maintain focus, concentration, alertness and attention. Dopamine is also the transmitter for a brainstem circuit that connects the substantia nigra and the striatum, helping control bodily movement and which partially dies off and malfunctions with Parkinson's disease.

When an electrical impulse travels down the length of a neuron, from the receiving dendrite, through the cell body, and down the transmitting axon (see Fig: 1) it triggers the release of packets of neurotransmitters into the synaptic gap. These transmitters hook onto receptors of the next neuron, triggering an electrical impulse which then travels down that neuron, causing yet another transmitter release. What Dr. Knoll and colleagues discovered through their highly technical experiments, is that deprenyi and phenylethylamine act more efficiently to couple the release of neurotransmitters.

Dr. Knoll believes that deprenyl's positive catecholamine effect explains its antiaging benefit. In addition, his work indicates that phenylethylamine is also a catecholamine substance. Phenylethylamine is a trace amine made in the brain that modulates (enhances) the activity of dopamine and noradrenaline neurons.

Autopsy studies have shown that while deprenyi increases dopamine levels in a Parkinson's patient brain by 40% to 70%, deprenyi increases phenylethylamine levels by 1300% to 3500%.

Phenylethylamine is the preferred substrate for MAO-B, the MAO that deprenyi inhibits. Paterson and colleagues have shown that phenylethylamine has an extremely rapid turnover due to its rapid and continuous breakdown by MAO-B. Thus deprenyl's catecholamine activity has a dual mode of action. At low, non MAO-B inhibiting doses, deprenyi has direct catecholamine enhancing activity.

At higher, MAO-B inhibiting doses, deprenyi creates an additional catecholamine effect, due to the huge increases in brain phenylethylamine levels that deprenyi causes, (phenylethylamine also being a catecholamine substance). Many authors have pointed out the probable dopamine neuron activity enhancing effect of phenylethylamine in Parkinson's patients taking deprenyi.

Therefore, Dr. Knoll's discovery of phenylethylamine's catecholamine effect now explains this phenylethylamine/ dopamineenhancing effect.

THE NEUROPROTECTOR Deprenyi has been shown to protect nerve cells from an ever-growing list of neurotoxins. Some of these neurotoxins can actually be produced within the brain under certain conditions, while others come from the environment or diet. Some of these neurotoxins are noted below: MPTP is a contaminant in synthetic heroin, however, compounds with a chemical structure similar to MPTP, include both natural and synthetic products, (e.g. paraquat), and are used in agriculture!

In other words, deprenyi causes a larger release of transmitters in response to a given electrical impulse. It's like "turning up the volume" on catecholamine nerve cell activity. This may be clinically very useful in various contexts such as Parkinson's and Alzheimer's disease, where the nigrostriatal tract and neural circuits underfunction. It can also be useful in depression, where there may be under-activity of both dopamine and noradrenalin neurons.

Dr. Knoll's research indicates that after sexual maturity, the activity of the catecholamine nervous system gradually declines, and that the rate of this decline determines the rate at which a person or animal ages.

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6-OHDA, is a potent neurotoxin that can spontaneously form from dopamine in dopamine using neurons. 6-OHDA may then further auto-oxidize to generate toxic superoxide and hydroxyl free radicals and hydrogen peroxide. Dr. Knoll's research has shown that pre-treatment of striatal dopamine-neurons with deprenyi can completely protect them from 6-OHDA toxicity.

Even in those not suffering from Parkinson's disease, the nigrostriatal neurons are the fastest aging neuron population in the human brain- with an average 13% loss every decade from the 40s on. Dr. Knoll and others believe that 6-OHDA neurotoxicity is a key cause of this "normal" nigral death, and that deprenyi may be able to retard this debilitating downhill neural slide.

DSP-4 is a synthetic noradrenaline nerve toxin. In rodents, deprenyi has been shown to

"after sexual maturity, the activity of the catecholamine nervous system gradually declines, and that the rate of this decline determines the rate at which a person or animal ages." prevent the depletion of noradrenaline that DSP-4 causes.

AF64A is a cholinergic toxin- it damages brain cells that use acetylcholine, (the neurotransmitter primarily affected in Alzheimer's disease). Deprenyi has been shown to protect cholinergic neurons from AF64A toxicity.

Deprenyi has also protected human nerve cells from peroxynitrite and nitric oxide toxicity.

Methyl-salsolinol is another MAO-B produced endogenous neurotoxin. Salsolinol is produced from the interaction of dopamine and acetaldehyde, (the first-stage breakdown product of alcohol). By inhibiting MAO-B, deprenyi reduces the toxic load on the brain that is routinely produced through the normal operation of MAO-B. MAO-B digests not just dopamine and phenylethylamine, but also tryptamine, tyramine and various other secondary and tertiary amines.

The above are just some of the many reports in the scientific literature on deprenyl's versatile neuroprotection.

PARKINSON'S DISEASE Parkinson's disease is one of the two major neurodegenerative diseases of the modern world, (Alzheimer's disease is the other). Parkinson's affects approximately 1 % of those over 70, a lesser percent of those 40 to 70, and rarely anyone below 40. Parkinson's is caused by a severe loss of dopamine, using nigrostriatal neurons, with symptoms manifesting after 70% neuronal loss, and death usually ensuing after 90% loss. (See Fig: 2).

The role of the nigral neurons is to inhibit the firing of the cholinergic neurons in the striatum.

When the nigral neurons fail in this negative feedback control, voluntary movement and motor control is "scrambled," leading to the typical Parkinson's symptoms of shuffling gait, stooped posture, difficulty initiating movement, freezing in mid-movement and the "shaking palsy." By the late 1960s the standard treatment for Parkinson's was the amino-acid precursor of dopamine, levodopa. The levodopa increased the dopamine levels in the few remaining nigrostriatal neurons in Parkinson's patients (80% of brain dopamine is normally located in nigral neurons), thus at least partially restoring normal movement and motor control.

After analyzing results of 1052 Parkinson's patients treated over 12 years, A. Barbeau wrote of levodopa that; "long-term side effects are 5

numerous.... although we recognize that levodopa is still the best available therapy, we prefer to delay its onset until absolutely necessary."

Deprenyl became a standard therapy to treat Parkinson's by the late 1970s. In 1985 Birkmayer, Knoll and colleagues published a paper summarizing the results of a 9-year study with levodopa alone, or combined with deprenyl in Parkinson's patients. They found a typical 1 to 2 year life-extension over the average 10-years from levodopa onset until death in the combined levodopa/ deprenyl group. The 1996 DATATOP study found that, "to the extent that it is desirable to delay levodopa therapy, deprenyl remains a rational therapeutic option for patients in the early stages of Parkinson's." In a 1992 paper, Lieberman cited 17 studies supporting the claim that; "...with levodopa-treated patients with moderate or advanced Parkinson's... the addition of [deprenyl] is beneficial." Thus, by the 1990s, deprenyl had become a standard Parkinson's therapy, used either to delay levodopa use, or used in combination with it. However, in 1995, a report published in ffie British Medical Journal seriously questioned the use of deprenyl in combination with levodopa to treat Parkinson's.

This study stood alone as being detrimental, but since then, it has been recognised that this particular study was deeply flawed, and consequently it can virtually be ignored.

ALZHEIMER'S DISEASE Alzheimer's disease is the most widespread neurodegenerative disease of modern times, affecting several million people in the U.S. alone.

Alzheimer's is characterized not only by severe memory loss, but also by verbal dysfunction, learning disability and behavioral difficulties, even hallucinations. Alzheimer's is known to involve damage to the cholinergic neurons of the hippocampus, but in addition to the reduction of acetylcholine, alterations have been observed in the activities of other neurotransmitters. In particular, cerebral depletion of dopamine can lead to memory and attention deficits, plus in Alzheimer's there is significant increase in MAO-B. Thus, with its combined MAO-B inhibition effects and catecholamine activity enhancing effects, deprenyl would seem "tailor-made" to treat Alzheimer's. Indeed, that is the conclusion of a 1996 review paper on Alzheimer's and deprenyl.

Tolbert and Fuller reviewed 4 single-blind and 2 open label deprenyl trials in Alzheimer's, as well as 11 double-blind deprenyl/Alzheimer's studies.

They noted that all 6 of the single-blind/open label studies reported positive results, while 8 of the 11 double-blind studies reported favorable results, typically utilizing a 10 mg deprenyl/ day dosage. In 3 of the single-blind studies deprenyl was compared to 3 Nootropics, oxiracetam, phosphatidylserine and acetyl-L-carnitine, and deprenyl was superior to all 3. Tolbert and Fuller were so impressed with deprenyl that they concluded; "...in our opinion, [deprenyl] is useful as initial therapy in patients with mild-to-moderate Alzheimer disease to manage cognitive 6

behavioral symptoms. In patients with moderateto-severe Alzheimer disease, [deprenyl's] efficacy has not been adequately assessed. However, given the lack of standard treatment, selegiline should be considered among the various treatment options."

"deprenyl was compared to 3 Nootropics, oxiracetam, phosphatidylserine and acetyl-L-carnitine, and deprenyl was superior to all 3" DEPRESSION Deprenyl has been used experimentally as a treatment for depression since the late 1970s.

While the causes of depression are diverse, it is now accepted that dysfunction of dopamine and noradrenaline neural systems is a frequent biochemical cause of depression.

In addition, the research of A. Sabelli and colleagues has established that a brain phenylethylamine deficiency also seems to be strongly implicated in many cases of depression. Given that deprenyl is a catecholamine activity enhancer, and that deprenyl strongly increases brain phenylethylamine through MAO-B inhibition, deprenyl would seem a rational treatment for depression.

Studies with atypical depressives, treatmentresistant depressives and major depressives have shown deprenyl to be an effective, low side-effect depression treatment. However, such studies have often required deprenyl dosages in the 20 mg or even 30 mg range. While these dosages caused little problem in these short-term studies, it is dubious to consider using such very high, non-selective MAO-B inhibition doses for long term treatment, (e.g. months or years).

In 1978, Mendelwicz and Youdim treated 14 depressed patients with 5 mg deprenyl plus 300 mg 5-HTP three times daily for 32 days. Deprenyl potentiated the antidepressant effect of 5-HTP in 10 of the 14 patients. 5-HTP enhances brain serotonin metabolism, which is frequently a problem in depression, while deprenyl enhances the dopamine/ noradrenaline activity. Underactivity of brain dopamine, noradrenaline and serotonin neural systems are the most frequently cited biochemical causes of depression, so deprenyl plus 5-HTP would seem a natural antidepressant combination.

In 1984, Birkmayer, Knoll and colleagues published their successful results in 155 unipolar depressed patients who were extremely treatment-resistant. Approximately 70% of their patients given 5 mg to 10 mg of deprenyl plus 250 mg of phenylalanine daily, achieved full remission, typically within 1-3 weeks. Some patients were continued for up to 2 years on treatment without loss of antidepressant action.

The combination of deprenyl plus phenylalanine enhances brain phenylethylamine activity, while both deprenyl and phenylethylamine enhance brain catecholamine activity. Thus, deprenyl plus phenylalanine is also a natural antidepressant combination.

In 1991 H. Sabelli reported successful results treating 6 out of 10 drug-resistant major depressive disorder patients. Sabelli used 5 mg of deprenyl daily, 100 mg of vitamin B6 daily, and 1-3 grams of phenylalanine twice daily as treatment. 6 out of 10 patients considered that their depressive episodes terminated within 2-3 days! Global Assessment Scale scores confirmed the patients' subjective experiences. Vitamin B6 activates the enzyme that converts phenylalanine to phenylethylamine, so the combination of low-dose deprenyl, B6, and phenylalanine is another biological way to enhance both phenylethylamine and catecholamine brain function, and thus diminish depression.

THE ANTIAGING DRUG Four series of rat experiments, as well as an experiment with beagle dogs, have shown that deprenyl can extend lifespan significantly, even beyond the "technical lifespan" of a species! Dr. Knoll reported that 132 Wistar-Logan rats were treated from the end of their second year of life with either placebo (saline injections) or 0.25 mg/kg deprenyl injected 3 times weekly, In the saline-treated group the oldest rat reached 164 weeks of age, and the average lifespan of the group was 147 weeks. In the deprenyl treated group, the average lifespan was increased by 30% to 192 weeks, with the shortest-living rat dying at 171 weeks and the longest-lived rat reaching 226 weeks, (a 38% increase).

In a second series of experiments, Dr. Knoll treated a group of 94 "low-performing" sexually inactive male rats with either saline or deprenyl injections, (0.25 mg/kg) from their eighth month of life until death. Dr. Knoll had already established a general correlation between sexual activity status and longevity in the rats. The salinetreated, low-performing rats lived an average 135 weeks, while the deprenyl-treated, lowperforming rats averaged 153 weeks of life. The saline treated, high-performing rats lived an average 151 weeks of life, while the deprenyltreated, high-performing rats averaged 185 weeks of life. In addition, 17 of the 50 highperforming, deprenyl-treated rats exceeded their estimated technical lifespan limit of 182 weeks.

Dr. Knoll's experiments were partially replicated

by Milgram and co-workers, and Kitani and colleagues. Milgram's group used shorter-living Fischer rats, while still starting deprenyl treatment at 2 years of age, (effectively later in their lives).

They also found a significant 16% increase in life span. The Kitani group, also using the shorterlived Fischer rats, started their deprenyl treatment at 1.5 years of age, and recorded a 34% life span increase.

Ruehl and colleagues performed an experiment with beagle dogs and deprenyl, administered at 1 mg/kg orally per day, for up to 2 years and 10 weeks. In a subset of the oldest dogs tested (10-15 years of age), 12 of 15 deprenyl-treated dogs survived to the conclusion of the study, while only 7 of 18 placebo-treated dogs survived.

By the time the first deprenyl-treated dog died on day 427 of the study, 5 placebo-treated dogs had already died, the first at day 295. Ruehl noted

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that; "dogs provide an excellent model of human aging." So this study takes on an added significance.

Dr. Knoll has repeatedly emphasized that the nigrostriatal tract, the tiny dopamine-using nerve cluster in the basal ganglia (or old brain), typically dies off at an average rate of 13% per decade starting at around 45 years of age in humans.

This fact literally sets the human technical lifespan (maximum obtainable by a member of a species) at approximately 115 years, since by that age the nigral neuron population would have dropped below 10% of its original number, (at which time death ensues, even if in all other respects the organism was healthy).

Based on the sum total of the animal deprenyl literature, and the 1985 study showing life extension in deprenyl-treated Parkinson's patients, Dr. Knoll has suggested the following: If deprenyl were used from the age of 40 something onward, and even if it only modestly lowered the nigrostriatal neuron death rate, i.e. from 13% to 10% per decade, then the average human lifespan might increase by 15 years, and the human technical lifespan would increase to roughly 145 years, (fig:2).

After 45 years of research, Dr. Knoll has concluded that; "the regulation of lifespan must be located in the brain." His research has further convinced him that; "it is the role of the catecholaminergic neurones to keep the higher brain centres in a continually active state, the intensity of which is dynamically changed within broad limits according to need." Dr. Knoll's research has shown that catecholaminergic nerve activity reaches a maximum at sexual maturity, and then begins a long, gradual downhill slide thereafter.

His animal research has shown catecholaminergic activity, learning ability, sexual activity and longevity to be inextricably linked.

Dr. Knoll argues that the quality and duration of life is a function of the inborn efficiency of the catecholaminergic brain machinery. In other

"research has shown catecholaminergic activity, learning ability, sexual activity and longevity to be inextricably linked." words, a high performing, longer living individual has a more active, more slowly deteriorating catecholaminergic system than their low performing, shorter living peer." His key conclusion is that; "as the activity of the catecholaminergic system can be improved at any time during life, it must be essentially feasible to [transform] a lower performing, shorter living individual to a better performing, longer living one." 1

DOSAGE AND SIDE EFFECTS Dr. Knoll consistently, throughout his deprenyl papers, recommends the use of 10 mg to 15 mg of oral deprenyl per week, starting in the 40s. Dr. Knoll's research clearly convinces him that deprenyl is both a safe and effective preserver of the nigrostriatal tract, as well as a catecholamine activity enhancer.

Deprenyl is undoubtedly an important antiaging drug. Plus, it is safe and effective, well validated (theoretically and experimentally), inexpensive (especially given the need for very low dosages) and what's more, it's available now.

REFERENCES Adapted from; "deprenyl- extending life span" by James South, MA. To read the original complete article along with all clinical references, please go to: http://www.antiagingsystems.com/extract/depren.htm

Fig: 2 This graph of Dean, Fowkes and Morgenthaler from the Smart Drug series of books, maps the decline of dopamine, occurring at an average of 13% per decade after the age of 45 for the "average" person. However, in Parkinson's disease this decline occurs much faster, leading to the progression of dementia and death at an earlier age. The concept that; "if we all lived long enough, we would all become senile" is indicated by this graph, and therefore highlights the importance of adopting a brain antiaging program."

warn Slow Aging People mmm Normal Aging People Average Parkinson's Patients Rapid Parkinson's Patients

Acetyl-L-Carnitine (ALC) A multi beneficial amino-acid Acetyl-L-Carnitine (ALC) is a naturally occurring amino acid that is related to L-carnitine. Recent attention has been placed upon its ability to protect and increase receptors in the brain that normally decline with age. ALC is being used in high doses and in combination with other Nootropics to treat senile dementias.

ALC has also been shown to help improve brain function by removing lipofuscin. Individuals discover that their short-term memory improves and their attention to detail is enhanced.

Perhaps most importantly for antiaging, ALC has been shown to improve the condition of the essential mitochondria, the vital source of energy production in the body.

I've learnt that ALC is particularly effective when taken with the synergistic combination of Centrophenoxine and Piracetam."

L.P.E., Oklahoma.

ALC is available to order from our web site or the product section at the end of this magazine.

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The Ultimate Inhibitor Phil Micans, PharmB

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The Glucose Cross-Linking Problem As long ago as 1942, Dr. Johan Bjorksten was working on what is now referred to as the Glycosylation Theory of Aging.

Glycosylation is the product of a reaction between sugar and the free amino group of proteins. This is commonly referred to as cross-linking. The linking of glycosylation by-products to proteins, results in the development of large, cross-linked molecules that inhibit the ability of the cell to function normally.

Dr. Bjorksten was a raconteur and often used "stories" to explain complex science. He described cross-linking by likening it to a factory where each day, more workers were handcuffed together.

Eventually work would grind to a halt, and in the same way, inter and intra molecular crosslinks inhibit cell performance and output.

It is believed that the cross-linking of the proteins that make up the human body, play a significant role in the human aging process. Everyone is familiar with the effects of cross-linking reactions, because the process causes food to turn yellow and become tough, (i.e. an apple that browns after it has been cut in half).

Cross-linking may be responsible for many of the problems associated with old age, including senile cataracts, thickening of the arteries, some cancers and damage to the immune system.

A damaged immune system leads to increased susceptibility to infection and some cancers may arise from the effects of glucose on DNA. Naturally, DNA contains all the information necessary to create a normal cell, however, it can react with glucose to produce damaged DNA, which in turn causes abnormal cells to be produced.

Cross 1 inking, Aging and the Heart Aging is associated with cardiac enlargement and arterial stiffening. This may be the result of the age-related accumulation of Advanced Glycosylation End products, (AGE).

One study conducted on animals showed that Aminoguanidine prevented age-related cardiac enlargement. In fact, the membrane surface area was reduced by 30%. Furthermore, the collagen content of their arterial walls was increased by 24% to 30%. Aminoguanidine is therefore acting to improve overall heart and arterial condition and not just by preventing or slowing proteins from cross-linking. It is also decreasing the AGE-induced cross-linking of the extracellular matrix.

Studies conducted at the University of Milan over the last 25 years, have shown Aminoguanidine's ability to do two things; Firstly, in tests on animals, Aminoguanidine has reduced the ability of very low density lipoprotein, (the bad form of FAX ORDERING +44 (0)208 I8I 6106

cholesterol) to bind itself to blood vessel walls. In turn, blood platelets are less likely to coagulate and form dangerous clots.

Secondly, Aminoguanidine has the ability to treat patients whose blood vessels are constricted by arteriosclerosis. At the University of Milan, 11 patients with peripheral vascular disease were treated with Aminoguanidine. Their blood vessels were so clogged that they couldn't walk for more than 500 meters, but after treatment, their blood flow improved on average by 30% and their ability to exercise improved by 50% to 105%.

Diabetes Diabetes is often seen as a form of accelerated aging, and research has provided support for the idea that cross-linking is a cause of aging. This is because the levels of cross-linked products in diabetics are two to three times higher than those found in nondiabetics.

It is believed that AGE is increased in diabetics and plays an important role in the development of diabetic complications. As Aminoguanidine acts to bind to sugars, thus preventing them from binding to the lysine group of proteins, it was only a matter of time before various trials began.

A number of different studies with diabetic animals indicate that Aminoguanidine administered subjects have significantly superior survival rates, compared to those who are untreated.

Diabetic clinical trials with humans have also highlighted Aminoguanidine's ability to prevent oxidative modification of low-density lipoproteins (LDL) and inhibit the formation of atherosclerotic plaques.

American trials were conducted with Pimagidine (which is another name for Aminoguanidine). They highlighted that Aminoguanidine can significantly reduce Albuminuria, (proteins present in urine, usually as a result of kidney disease), delay the onset of end-stage renal disease and improve the cholesterol profiles of diabetic patients.

Research has shown that glucose is partly responsible for the cross-linking of proteins, which in turn leads to aging damage. Glucose is found in every cell of the body and is relatively stable, but can join with protein to form a glucose/ protein combination. It is this combination that will continue through a number of steps, to eventually cause active cross-links.

The good news is, that the formation of this process appears to be reversible.

Glucose/ protein substances stay in the body for months, even years, crosslinking with the proteins around them.

"Aminoguanidine may be able to help alleviate or prevent senile cataracts, thickening of the arteries, kidney failure, thinning bones, osteo-arthritis, skin wrinkles and many other signs of degeneration caused by aging."

This continuous cross-linking may be prevented by using glycosylation inhibitors, such as Aminoguanidine, to help stabilize the metabolism of glucose.

Aminoguanidine is able to join up with substances that cause links, and helps to stop cross-links from developing. Consequently, it may be able to help alleviate or prevent senile cataracts, thickening of the arteries, kidney failure, thinning bones, osteo-arthritis, skin wrinkles and many other signs of degeneration caused by aging.

Aminoguanidine's ability to stabilize the metabolism of glucose, help prevent and treat adult onset diabetes, reduce very low density lipoprotein cholesterol, and the evidence that it can improve blood flow, (helping to reverse the conditions of arteriosclerosis and blood clots), indicates that Aminoguanidine can help prevent and treat a number of aging disorders.

As all the body's proteins deteriorate with advancing age (and much more so in diabetes), Aminoguanidine has the potential to slow the aging damage process by protecting the proteins that make up the human body. In particular, these are skin proteins (collagen and elastin), eye lens protein, nerve protein and kidney proteins.

Aminoguanidine is able to combat some of the adverse effects of diabetes and improve the quality and duration of life. Furthermore, as diabetes is an age-related disorder, and in-fact affects everyone over the age of 30 (because physicians alter the parameter of the test based upon chronological age), Aminoguanidine can be considered, a true anti-aging medicine.

It is becoming clear that agents that slow, prevent and even reverse the effects of cross-linking, will have a major impact in the role of preventative medicine. Additionally, products that directly impact upon a theory of aging, such as the Glycosylation Theory of Aging, can indeed claim to be true antiaging medicine.

Adapted from; "Aminoguanidine: An AGE inhibitor" by Phil Micans. To read the original, complete article along with all clinical references and dosage recommendations, please go to: http://www.antiagingsystems.com/extract/skinaging.htm 9

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Is the Recommended Dietary Allowance for Vitamin C Too Low? Got a bottle of vitamin C somewhere in the kitchen cupboard? Most Americans do. A quick examination of the label on the back of the bottle reveals 60 mg provides 100% of the Recommended Dietary Allowance. That's far from what Dr. Linus Pauling suggested to achieve optimal human health. Dr. Pauling consumed 18,000 mg per day, claiming this water-soluble vitamin needed frequent replenishment through the day to achieve optimal health. Now freshly published research confirms many of Dr. Pauling's suggestions, but not without plenty of controversy.

VI

Vitamin C advocates go on the offensive Now, however, vitamin C advocates are about to go on the offensive. In their new book, Ascorbate: The Science of Vitamin C (www.lulu.com), Professors Steve Hickey and Hilary Roberts at the University of Manchester in Great Britain allege the RDA for vitamin C has mistakenly been set too low. For the past year the British professors have been taking researchers at the Institutes of Medicine (IM) and the National Institutes of Health (NIH) to task for faulty science. Drs. Hickey and Roberts claim researchers established the current RDA for vitamin C without recognition of its half-life. In about 30 minutes, half of any dose of vitamin C disappears from the human body. The RDA was established by measuring blood plasma levels of vitamin C 12 hours, or 24 half-lives, after consumption. "To be blunt," says Hickey, "the NIH gave a dose of vitamin C, waited until it had been excreted, and then measured blood levels."

Vitamin C advocates on the defensive

Desmopressins' effects rapidly improve shortterm memory and enhance memory imprinting.

When Desmopressin is taken before an event, it enables the event to be recalled with more detail later. Whereas "normal" memory-drugs improve the capability to remember past events easier and faster, Desmopressin helps us to remember events better! This type of effect is referred to as memory imprinting.

Desmopressin is of particular benefit before lectures, business meetings and other such occasions.

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Considerable disagreement has ensued in the past decade over how much vitamin C should be consumed by adults. Vitamin C advocates have continually been on the defensive.

The most recent negative news story about vitamin C emanated from Duke University where researchers mistakenly concluded from an animal study that more than the Recommended Dietary Allowance for vitamin C may worsen joint problems. But an earlier large-scale human study showed that adults who consume high-dose vitamin C experience a 3-fold reduction in the risk for progression of their knee osteoarthritis and that supplemental vitamin C reduces knee pain. [Arthritis Rheumatism 39:648-56, 1996] How did an animal study receive so much publicity when a contrary human study had already been published?

Then back in 2001 a paper in Science Magazine errantly claimed that high-dose vitamin C might damage DNA. Again, the recommendation was to limit supplemental vitamin C to no more than the RDA. However, this recommendation was again based a test-tube study. Five human studies had already been conducted proving high-dose vitamin C does not damage DNA, but were overlooked by the reviewers at Science Magazine. When I called this to their attention they printed my rebuttal letter which cast doubt on the test-tube study which errantly warned the public away from high-dose vitamin C supplements.

Furthermore, the IM and NIH developed the current RDA using studies of just 15 subjects, not nearly enough to statistically establish an RDA for a population of 280 million people.

Hickey and Roberts claim the amount of vitamin C needed for optimal health is likely to be more like 2500 mg per day, nearly 42 times greater than the current 60 mg RDA. Recent studies authored by NIH researchers confirm that the saturation point for vitamin C in blood plasma is not fully achieved even when taking doses as large as 2000 mg per day. Some of these studies now even confirm Dr. Pauling's claims that high-dose vitamin C may be effective against cancer.

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century stimulants

here are a new breed of stimulants in town and they call themselves Eugeroics.

Taken from Greek, Eugeroic simply means "good arousal," but eugeroics form a unique class of drugs and contain only two at present. They are Adrafinil and Modafinil, (both of which have been developed by Lafon Laboratories of France).

The popular press has picked up on their ability as "lifestyle drugs" to improve people's work and concentration ability, you may know some of the trade names such as Provigil, Modiodal or Olmifon.

The basis of their uniqueness lies in their ability to only "stimulate when stimulation is required." As a result, the "highs and lows" associated with other stimulants such as amphetamine, appear to be absent with eugeroics.

Eugeroics have been designed to treat narcolepsy (sleeping in the day), hypersomnia (excessive sleep) and cataplexy, (a condition of sudden muscular weakness or fatigue). Yet uniquely, eugeroics don't affect normal sleep patterns, nor are they addictive and they have far fewer side effects than the previously prescribed stimulants.

Modafinil's Unique Stimulation One animal study suggested that a possible vigilance enhancing property of Modafinil was its ability to inhibit the release of GABA, through an action on 5HTP serotonin receptors. However, the doses used were far higher than normal therapeutic doses. So meanwhile, most clinical studies point to Modafinil as a unique and highly selective agonist of brain postsynaptic receptor sites called, alpha-1 adrenergic.

These alpha-1 sites are receptive to the neurotransmitter- Noradrenaline (also known as Norepinephrine). The central function of Noradrenaline is a relatively recent discovery, it appears to regulate alertness and the waking/ sleep cycle and has a role in the maintenance of attention, memory, learning, cerebral plasticity and even has neuro-protection qualities.

Central nervous stimulants (CNS), such as Amphetamine or Pemoline are the most widely used drugs to treat narcolepsy, hypersomnia and cataplexy, but these have a number of well documented problems, particularly cardiovascular side effects, as well as interference with sleep, psychiatric disturbances and addiction.

Two studies directly compared the affects of Modafinil and the "classic" stimulant, d-amphetamine on sleep. Both double blind controls involved about twelve individuals. One study was undertaken with individuals whose mean 12

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"uniquely, eugeroics don't affect normal sleep patterns, nor are they addictive and they have far fewer side effects than the previously prescribed stimulants."

age was 68, the other on much younger volunteers. They utilized 100 mg. or 200 mg. of Modafinil, or 10 mg. or 20 mg. of d-amphetamine, or a placebo. All the drugs were administered orally and sleep scales, awakening quality and psychometric tests were completed in the morning.

The outcome of both tests showed that d-amphetamine caused a dose dependant impairment of sleep maintenance, but Modafinil did not. Here in lies a problem for those who have difficulty staying alert and awake during the day.

The use of "classic" stimulants, such as amphetamines, threatens to reduce total sleep time and REM (rapid eye movement) sleep, and this will ultimately mean higher and higher doses are required, thus creating a vicious circle.

On the other hand, Modafinil has not been shown to interfere with night time sleep, thus clearly indicating that the two compounds operate by different methods.

Clinical Trials Numerous studies on animals since the mid 1980's, have confirmed the ability of Modafinil to increase awakeness and alertness, without serious side effects, or dependency.

One animal test produced an interesting result. The researchers discovered that Modafinil decreased feeding and thereby reduced body-weight! The amounts of Modafinil required were not dose dependent and there was no alteration in the drink-feed ratio. Their conclusion was an interesting reference

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to the possible mechanisms that underlie the relation between sleep, feeding and metabolism.

Various human trials have concentrated upon Modafinil as a therapeutic agent to help maintain alertness and vigilance. A noteworthy conclusion of one clinical trial, compared Modafinil to amphetamine and described amphetamine as "vigilance increasing," but Modafinil as "vigilance promoting." This is an interesting comment because as we've seen, Modafinil won't prevent a person from sleeping if they want to, but if they wish to remain awake, they will do so with a far greater degree of alertness.

This was borne out in one clinical trial, where volunteers were subjected to 60 hours of sleep deprivation! During their continued wakefulness, their vigilance was assessed using questionnaires; analogue visual scales and sleep latency tests. The subjects received either 200 mg. Modafinil, or a placebo every 8 hours.

The Modafinil group sustained a satisfactory level of vigilance with an absence of sleep episodes, unlike the placebo group who gradually declined and slipped into "micro-sleep" episodes, (as one might expect when awake for longer than 24 hours).

A French study, conducted over 3 years, discovered that Modafinil reduced drowsiness in 83% of hypersomniac patients and 71% of narcoleptics.

Modafinil did not produce peripheric side effects, disturb night sleep and it was never responsible for drug dependence.

Another French study conducted with 149 patients over a period of 2 years, treated patients with narcolepsycataplexy at 200 mg. to 400 mg. daily.

The patients were then asked to score the benefit of Modafinil themselves, from 0 (no affect) to 3 (excellent affect), 64.1% of the subjects scored it as excellent.

An earlier study, with 123 patients, (which also included those suffering with hypersomnia), the physicians evaluated the patients on a scale of 1 (no affect) to 4 (excellent affect). The results? 17% excellent response, 63% good response, 17% fair and 3% no affect. The incidence of side effects were minimal, (14 of the 123 patients had side effects, 11 of whose side effects disappeared when doses were reduced).

These results have been repeated in a number of smaller clinical trials, and confirm Modafinil's excellent response to treating individuals suffering with narcolepsy, hypersomnia and cataplexy. Its efficacious use, in conjunction with a virtual absence of side effects, noncontraindication with normal sleep patterns and lack of drug dependence, certainly indicates that eugeroics are a breed apart from conventional stimulants.

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The Military Involvement It is fascinating to see that several countries armed forces have studied, and indeed use Modafinil for military operations. The use of stimulants to keep troops awake and alert is not a new one.

It is known that British troops used them during the Falklands conflict and that USAF aircrews took amphetamines during the Libyan air strikes.

The French government even admitted that its crack Corp- The Foreign Legionused Modafinil for covert operations inside Iraq, during the Gulf war. In-fact, Professor Michel Jouvet, an authority on sleep, claimed during an international defense meeting in Paris that, "Modafinil could keep an army on its feet and fighting for three days and nights with no major side effects."

Not surprisingly then, we have heard that Modafinil is in use in some sections of the Belgian, Dutch and US airforces.

Dosages and Side Effects Side effects in continuous studies of therapeutic dosages of Modafinil, lasting 3 or more years have been minimal and usually noted as nothing more than headache or nausea. In rare cases there has been hyper-salivation and moderate tachycardia (increased pulse rate), this probably accounts for Modafinil's instruction sheet, which states that those suffering from a heart condition must consult their physician before use.

However, blood and pulse rates usually remain unchanged at normal therapeutic doses. In-fact, a suicidal 21-year-old female who ingested 4500 mg. demonstrated the relative safety of Modafinil.

Her side effects were limited to tachycardia, excitation and insomnia. As is common with most drugs, Modafinil should not be used by those with serious liver disorders, nor those women who are pregnant or nursing.

The official insert for the Modafinil package remains unclear as to the precise drug contraindications, but as it is an alpha-adrenergic agonist, those drugs that represent alpha-adrenergic antagonists should be avoided. These include prazosin, phentolamine or beta-blockers such as propranolol (Inderal).

Furthermore, drugs that enhance norepinephrine activity, (such as yohimbine) should only be used with care, as there may be a synergistic affect. Adrafinil is noted as contraindicated with epilepsy and has been shown to enhance the potency of anti-epileptic drugs such as phenytoin, (Dilantin/ Epanutin). Although this isn't mentioned in any of the Modafinil literature we have read, it is best being advised of.

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As for dosages, there seems to be little difference in doses and more importance is placed upon regular administration.

Those who simply wish to remain awake and alert will benefit from a single 100 mg. dose. To remain "on-call" all day, 100 mg. in the morning and another 100 mg. in the afternoon is probably all that is required. For those wishing to remain awake during the night, then another 100 mg. in the late evening, (in other words approximately every 8 hours).

Dosages for those suffering from narcolepsy, hypersomnia and cataplexy are 100 mg. to 200 mg. morning and afternoon. Some of the doses in trials have been as high as 600 mg. to 700 mg. daily, although doses over 500 mg. daily may cause euphoria, motor excitation or even insomnia!

Adrafinil and Modafinil Compared Adrafinil was the world's first eugeroic, and developed some years before the introduction of Modafinil. At first glance there may appear to be little difference between the two. It is true that Modafinil is more potent, "average" doses of Adrafinil are in the region of 600 mg. to 1200 mg. daily, compared to Modafinil's 200 mg. to 400 mg. daily and this is self evident by the respective tablet sizes (300 mg. for Adrafinil and 100 mg. for Modafinil).

We were going to reiterate and condense the above article into a few lines, but the conclusion of the Aerospace Medical Association article on Modafinil was so pointed, we will leave the last words to them.

"The development of Modafinil brings to light a crucial social question. What would be the impediment for its use, if a compound such as Modafinil is more like caffeine than amphetamine in terms of safety, and yet, as effective as the amphetamines?" LJ References Adapted from; "Eugeroics- the ultimate stimulants" by Robert Mason, Ph.D.. To read the original complete article along with all clinical references, please go to: http://www.antiagingsystems.com/extract/eugeroics.htm

Deprenyl Liquid

However, if one were to compare Adrafinil and Modafinil on price alone then Adrafinil would win hands down! So the question must be asked, why did Lafon produce an analogue of Adrafinil?

The answer probably lies in two parts.

Firstly, it is thought that Adrafinil may not be such a highly selective alpha-1 adrenergic as originally thought, and may also affect other alpha receptors (albeit in a minute fashion).

Secondly, Adrafinil is attributed to some other possible side effects that have not been associated (to date) with Modafinil, including, stomach pain, skin irritations, inner tension and in long term use, (over 3 months usually), an increase in liver enzyme levels, (which is reversible by reduction or withdrawal). It is our guess that it is the last potential side effect that lead to the development of Modafinil. Clearly, continuous Adrafinil use would require regular blood testing to monitor liver enzyme levels, and this is obviously inconvenient to those patients who need to use eugeroics on a regular basis.

As none of the clinical reports we have read indicate any such problem with Modafinil, it would appear that the analogue has achieved its desired aim.

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; Safe as Caffeine, Strong as Amphetamine

www.antiaging-magazine.com 13

All of our skin is affected by age without exception, but some segments are more vulnerable than others and components of skin age at different rates and degrees.

This is due to individual genetic variations, as well as external factors and influences such as sun exposure, diet and pollution.

The skin is the largest organ in the body covering an area on average of about 1.49 square meters. Its main aim is to protect the body from the external world. Another of its functions is to provide sensory information about temperature, touch, pain and vibration etc. The skin is also a secretory organ which eliminates toxins through perspiration.

Components of the Skin The epidermis is the outermost layer of the skin which protects it from injuries.

When it comes to treatment, the problem is that it may be difficult for nutrients and pharmaceutical agents to penetrate the epidermis, and reach the inner layers of the skin. Scientists have invested a great deal of research in finding effective ways of delivering nutrients where it matters, deep into the skin. Liposomes are one such way, making use of tiny particles surrounded by lipid molecules which are able to penetrate the outer layers of the skin, carrying the nutrient or other chemical with them.

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The main constituents of the dermis, (the inner layer of skin) are collagen and elastin. The collagen and elastin infrastructure keep the skin resilient, elastic and firm. Collagen fibres are strong protein molecules which form a scaffolding to support other skin structures. Elastin fibres also form a mesh or net allowing the skin to maintain its elasticity and firmness. These two types of molecules can be considerably weakened by age-related processes, such as glycosylation and oxidation.

Photo-damage, (i.e. damage caused by the UV radiation of the sun) is also a major cause of collagen and elastin destruction.

Before the dimples turn to wrinkles

Apart from the collage/elastin network, other components of the dermis are cells, (such as fibroblasts), fatty tissue, nerves, blood vessels, sweat glands, hair follicles and sensory structures.

A major component is the intracellular matrix. This is formed by a mixture of protein/carbohydrate molecules surrounded by water. The main functions of the intracellular matrix are to facilitate the nutrition of the various skin components and to protect the skin against external insults. The fluid nature of the intracellular matrix gives the skin its plump, youthful and rounded appearance.

By Marios Kyriazis, M.D. I4

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Within the matrix, moisture is retained by various substances such as NaPCA, a natural moisturiser. The problem is, the concentration of NaPCA diminishes with age and this causes progressive loss of moisture from the skin. However, the aging of the skin is a complicated process involving several interrelated factors.

How Age Affects the Skin Strictly speaking, there are two types of skin aging. The intrinsic (or chronological) aging accounts for about 10% of all skin aging and is characterised by thinning of the skin, loss of elasticity and a decreased metabolic activity. The other 90% of skin aging happens as a result of photoaging, which causes damage to the skin followed by an exaggerated repair reaction resulting in collagen and elastin degeneration, dilatation of the small vascular vessels, deposition of abnormal elastin and collagen, and increased skin pigmentation.

Intrinsic skin aging is due to genetic factors and endogenous influences such as oxidation and glycosylation, whereas extrinsic aging is due to external factors such as UV radiation, stress, pollution, and other environmental insults.

Free radicals are the main culprits commonly implicated in causing skin aging. Oxygen and nitrogen free radicals are produced by cigarette smoking, environmental pollution, inadequate nutrition, pesticides, food chemicals, and most importantly, by UV action'upon the skin. When UV radiation interacts with the skin, it produces an excessive number of free radicals which destroy collagen, elastin and other proteins in the skin. UV radiation also interacts with the DNA inside skin cells causing further damage by allowing faulty DNA to replicate. In this way, imperfect DNA transcription and defective protein formation is perpetuated.

Chromophore skin cells are specialised cells which absorb much of the UV radiation, but with age, their activities diminish resulting in more UV radiation reaching the inner parts of the skin. Years of this process will result in skin losing its moisture and support, appearing less shiny, wrinkly and droopy, with other noticeable imperfections. The risk of skin cancer is also considerably increased.

This is one of the reasons that protection from the sun is paramount to maintain healthy, youthful looking skin for the longest time. [Ed - This subject was covered in the Summer 2004 issue of the Antiaging Magazine, and centred on the work of Professor John lonescu, and the development of a unique sun protection cream called Solaris ®, further details of FAX

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which can be viewed at: http://www.antiagingsystems.com/a2z/solaris.htm] Skin Glycosylation When glucose molecules interact with skin proteins they may form glycosylated proteins, which are generally more susceptible to damage caused by free radicals. A glycosylated protein may interact with another causing crosslinking, which is an irreversible union between two molecules. When this happens, neither of the molecules is free to perform its ordinary functions, and this contributes to further overall damage. An additional problem is that the cross-linked unit may then interact with other oxidised molecules, resulting in large and harmful molecules called AGEs (Advanced Glycosylation End products). These perpetuate the damage to the skin collagen, elastin and intracellular matrix, and increase the death rate of the fibroblasts.

Glycosylation may also be caused by other toxic by-products and is connected with various inflammatory pathways, stimulating production of inflammatory chemicals such as tumour necrosis factor (TNF) and nuclear factor kappa b (NFkB).

These inflammatory agents attack other skin cell material resulting in chronic skin micro-inflammation, which not only makes the skin appear red, rough and itchy, but causes wrinkles and skin blemishes.

Therefore, the combined action of oxidation, glycosylation and chronic inflammation results in the visible signs of skin aging such as wrinkles and rough skin.

Other age-related changes to the skin include:

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The formation of age-spots, which are the result of lipofuscin accumulation.

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Increased likelihood of skin cancer such as melanoma and squamous cell carcinoma.

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Thin and easily fragile skin, with easy bruising, deformed capillaries and varicosities.

Apart from the visible sings of aging, there are other less visible changes. For example, the sweat and sensory elements of the skin become affected with age. Sweating becomes more problematic and less effective. As a consequence, elimination of toxins from the skin declines, and toxins may thus accumulate in the body. (An exception to this is the increased sweating sometimes

"90% of skin aging happens as a result of photoaging"

experienced by menopausal women, which is hormone-related). The sensory organs of the skin become less sensitive, and information about outside temperature, touch, pain and stretching becomes less reliable.

Preventing and Treating Skin Aging Coenzyme Q10 Studies show that Coenzyme Q10 applied directly to the skin helps reduce the appearance of wrinkles and fine lines, it also promotes the repair of fibroblasts.

But after the age of 30-35, the body becomes less able to create enough Coenzyme Q10 to meet its energy needs.

This is made worse by bad eating habits, stress, infection and certain drugs.

Coenzyme Q10 can significantly suppress the expression of collagenase, an enzyme which destroys collagen. In addition, it can penetrate the outer layers of the skin and exert antioxidant benefits deep in the dermis.

Combining topical co-enzyme Q10 with other known antioxidants such as vitamin E together with RNA extracts, (which help maintain the skin's own DNA) is an effective way of ensuring all round skin anti-aging protection.

The specialist German cream, NeySkin is specially formulated with CoQ10, RNA skin extracts and vitamin E. Further details can be viewed at: http://www.antiagingsystems.com/a2z/neyskin.htm Idebenone Idebenone has a chemical structure similar to that of Coenzyme Q10, but it is believed to be a more effective and stronger variant. Idebenone is a very effective antioxidant, 400 times stronger than vitamin E and it has been used not only as a skin rejuvenator but also as a brain protector and heart nutrient. [Ed.details of Idebenone were posted in an article that appeared in the Fall 2004 issue of the Antiaging Magazine). i5

"Oxidation, glycosylation and chronic inflammation, together with hormonal deficiencies, cause aging of the skin."

Idebenone is available in 30 mg capsules, further details can be viewed at: http://www.antiagingsystems.com/a2z/idebenone.htm Aminoguanidine Due to the important role of glycosylation and cross-linking in causing skin aging, researchers are interested in agents which can inhibit, modulate and control glycosylation. One such agent is Aminoguanidine. It helps prevent glycosylationrelated collagen destruction and it is used in order to protect against skin roughness, age-spots, wrinkles and other blemishes.

Specifically, Aminoguanidine works by blocking the expression of metalloproteinases. These are digestive enzymes which destroy the components of the matrix, resulting not only in skin aging but also in arterial and kidney disease. Metalloproteinases are induced by UV radiation and their action depends on the nitric oxide radical (NO). Scientists from the Division of Chemical and Biological Engineering, Konkuk University, Seoul, have shown that when Aminoguanidine is added to a solution containing metalloproteinases, it significantly reduces their activity.

Translated into clinical terms, this means that Aminoguanidine has an additional benefit in protecting the intracellular matrix against age-related changes.

It is known that the formation of AGEs contributes towards activation of metalloproteinases and enhances the degradation of collagen. However, Aminoguanidine, (which reduces AGEs) may have an important effect upon this process by reducing metalloproteinases as described above, and by protecting the intracellular matrix against age-related changes.

Glycosylation inhibitors are contained in Energo cream. Further details can be viewed at: http://www.antiagingsystems.com/a2z/energo.htm Aminoguanidine is also available in 75 mg tablets. Further details can be viewed at: http://www.antiagingsystems.com/a2z/aminoguanidine.htm Carnosine Beta-alistine 速 is a commercial preparation of topical carnosine, but it is also 16

possible to use carnosine in oral doses as an effective way to prevent skin aging.

Carnosine is a dipeptide, (a combination of the aminoacids alanine and histidine) which works in three different ways: 1. It prevents lipid peroxidation affecting the skin cell membrane.

2. It reduces the risk of glycosylationinduced damage.

3. It modulates agents causing microinflammation of the skin.

Carnosine has been thoroughly investigated in terms of wound healing. It possesses several healing properties as an antioxidant, metal chelator and inflammation regulator. During wound healing there is an increased production of good quality collagen and proliferation of healthy fibroblasts. The balance between adequate and excessive formation is quite delicate and, if disturbed, it may result in excessive scarring.

Carnosine can modulate the production of factors which regulate the equilibrium, thus preventing scar formation. The same is true for age-related skin damage where there is an attempt by the body to increase the formation of collagen and fibroblasts to replace those elements which had perished through lysis or though apoptosis respectively. Carnosine is an essential nutrient in this respect. In addition, carnosine can protect against UV radiation, so can be useful for individuals, who despite using sun screening lotions, are still liable to skin damage.

Carnosine is available as a topical cream and in 50 mg capsules. Further details can be viewed at: http://www.antiagingsystems.com/a2z/carnosine.htm Centrophenoxine Although Centrophenoxine is a known brain booster, it is also beneficial for the skin. Centrophenoxine dissolves and removes deposits of lipofuscin, which is the inert material left over after normal metabolic reactions have taken place in the body.

Lipofuscin is responsible for age spots, the raised, brownish patches commonly seen on the back of the hands and elsewhere on the skin. Regular use of Centrophenoxine can help reduce or prevent age spots by reducing the amount of lipofuscin.

Centrophenoxine is available in 250 mg capsules, further details can be viewed at: http://www.antiagingsystems.com/a2z/centrophenoxine.htm ONLINE

DHEA A natural molecule, Dehydroepiandrosterone plays an important role against aging in general and against skin aging in particular. Taken in oral form or applied topically, DHEA increases the immune resistance of the skin, which in turn prevents inflammation-induced skin damage. It also stimulates the production of collagen and elastin and improves skin cell metabolism.

In a classic experiment, 280 healthy volunteers aged 60-79 years were treated with 50 mg DHEA or placebo (in oral form), daily for a year in a double-blind, placebo-controlled clinical trial. The results showed that there was a restoration of the age-related decline of DHEA concentration back to youthful levels.

Additionally, there was a small increase in testosterone and estradiol, especially in women patients. In the patients who were given DHEA, their skin exhibited significant improvement particularly in relation to hydration, epidermal thickness, sebum production, and abnormal discoloration.

No side effects were reported. This demonstrates the promising effects of DHEA used specifically for skin health.

DHEA is available in sublingual liquid as well as 25 mg and 50 mg capsules.

Further details can be viewed at: http://www.antiagingsystems. com/a2z/d hea .htm Topical Estrogens Menopausal or post-menopausal women find that regular use of estrogencontaining creams helps their skin appear smooth, young and healthy. Loss of ovarian estrogen secretion which is encountered during the menopause is responsible for, among other problems, thinning of the skin, loss of hair, cellulite and loss of skin tone. A new medical discipline, called aesthetic endocrinology, is a study of how hormones can be used topically to help prevent age-related skin problems.

Aesthetic endocrinologists have suggested that estrogen creams play a pivotal role in this respect, but research into the benefits of topical estrogen continues. Coincidentally, estrogen cream does not only have effects locally, but is absorbed and goes on to produce well-known systemic benefits, (prevention of osteoporosis, control of menopausal problems etc.).

A natural triple estrogen cream, called Esnatri is available and further details can be viewed at: http://www.antiagingsystems.com/a2z/estrogennat.htm

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Other Hormones Topical progesterone, testosterone, melatonin and human growth hormone all have skin benefits.

Hormonal deficiencies associated with aging cause a variety of skin related disorders such as thinning of the skin, easy bruising, loss of hair, appearance of fine lines and blemishes, skin dehydration and loss of muscle tissue which makes the skin appear less well supported.

The antioxidant effects of melatoninhave been well studied in laboratory animals and there are also human trials underway, in particular topical Melatonin is such a potent natural anti-oxidant, it has been proven to be efficacious for the skin of people undergoing radiotherapy treatment for cancer. [Ed.- for further details see Professor Zaenker's article at: http://www.antiagingsystems.com/extract/skinandradiotherapy .htm] Melatonin is available both in oral and topical forms, further details can be viewed at: http://www.antiagingsystems.com/a2z/melatonin.htm Progesterone and testosterone are used to counteract age-related hormonal deficiencies and they can be applied topically in cream or patch forms. Topical progesterone may work more effectively when combined with an estrogen cream, because the two hormones work synergistically in physiological situations.

Progesterone is available in a topical spray form. Further details can be viewed at: http://www.antiagingsystems.com/a2z/progesterone.htm Growth hormone (GH) is used parentera l ^ and acts systemically. Among other benefits, GH boasts an improvement in skin tone, restoration of the normal skin thickness and a re-balancing of the underlying fatty tissues of the skin.

Injectable human growth hormone details can be viewed at: http://www.antiagingsystems.com/a2z/hgh.htm Lack of another hormone, thyroxine may be associated with thinning hair, dry and itchy skin and weight gain. Thyroid extracts, or pharmacologically active thyroxine hormone, should be able to reverse these skin changes, particularly if used early in the course of the disease.

For best results hormonal treatment should be combined with some of the nutritional supplements mentioned above.

Thyroid supplement information can be viewed at: http://www.antiagingsystems.com/a2z/thyroid.htm FAX

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Retin-A The retinoids, (derivatives of vitamin A) are a group of chemicals which have consistently and repeatedly been found to prevent and even reverse age-related skin damage. Retinoids work in a variety of ways. One of the most important is the antioxidant action, but not only do they prevent oxidation and lipid peroxidation, but they also interact with AGEs to limit glyco-oxidation, (damage caused by glycated material interacting with free radicals).

Retin-A is an effective skin protector, which stimulates the expression of one of the commonest forms of collagen in the skin, type VI collagen. In particular, topical retinoids such as Retin-A influence glycosyltransferases (enzymes responsible for carbohydrate synthesis) and thus affect the rate of skin glycosylation.

Clinically, Retin-A reduces wrinkles and fine lines if used regularly for several weeks.

Retin-A is available in two different strength creams and details can be viewed at: http://www.antiagingsystems.com/a2z/retina.htm Summary Oxidation, glycosylation and chronic inflammation, together with hormonal

deficiencies, cause aging of the skin.

Excessive sun exposure, pollution, stress and other environmental factors may accelerate this process, resulting in signs of premature skin aging. A combination of hormonal, nutritional and pharmacological approaches may retard or even reverse this process.

Using a single treatment on its own is unlikely to show any major benefit, due to the multifaceted nature of skin aging. But using treatments which have multiple actions may prove beneficial, not only for the skin, but for other organs in the body.

[Ed.- If you wish to learn more about skin aging then we recommend you read "The Look Young Bible" published by Foulsham in 2002, ISBN 057202729-X, written by Dr. Marios Kyriazis. This book and many others can be purchased directly through the IAS website. For further details go to: http://www.antiagingsystems.com/publications/home.htm] References Adapted from, "Skin aging, when the dimples become wrinkles", by Marios Kyriazis, M.D. To read the original complete article along with all clinical references, please go to: http://www.antiagingsystems.com/extract/skinaging.htm 17

INTERVIEW

A day in the life of an antiaging clinic

American born Heather Bird is the President of HB Health, and is also a Director of the World Academy of Antiaging Medicine. Her London clinic, HB Health of Harley Street, focuses on internal antiaging medicine and preventative health, while her newly opened HB Beauchamp Place, specializes in external antiaging and beauty services.

AAM: Thank you Heather for taking the time out of your busy schedule to talk a bit about the operation of an anti-aging clinic. Perhaps you could tell our readers what made you personally get involved in preventative medicine?

Heather: In my formative years I worked with the UN World Health Organization in Switzerland. During my time with them I got to visit many geriatric wards. A lot of what I saw there made me feel sad; knowing how different many of these people must have been in their youth, in some cases just a few years beforehand. I started to think that this kind of debilitating and degenerative aging is a disease, and that's when I became an ardent advocate of antiaging or anti-degeneration if you prefer.

AAM: I think we can all sympathise with that point of view. I've often said myself that if anyone is feeling down for any reason, they should pop along to the local hospital and visit the geriatric ward. They always welcome visitors to talk with the patients; but after an hour or two, it will soon become apparent that compared to them, one has no worries at all! Let me say Heather, you are in an interesting position, as an American living in Europe, how do you find the people of different countries compare with their view to health and beauty?

Heather: There are not as many differences as most people might think, but on the whole I think that Americans embrace new ideas more readily than Europeans. It's often said that

Interview by Phil Micans 18

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Europe is 5-years behind new trends in America, and that's certainly true for antiaging medicine in general.

AAM: Personally I find that whilst Europe has a lot more drugs, and certainly has cheaper prices on the majority of them- compared to the States, that the opposite is true of nutrition. In its broadest sense, Europeans have less access to nutrition and certainly pay more for them. As the 1996 U.N Codex Alimentarius Commission launched a worldwide initiative to restrict access to natural medicines, and which now has been effectively been translated into law by the EU, it may be as early as August 2005 that the European Food Supplements Directive could become active. This is estimated to be able to remove over 5000 vitamin formulations from shops and dramatically cut the dosage of many others. In addition, the Herbal Medicines Directive- under consideration by the European Parliament, will prevent any new herbal formulas from ever coming onto the market and remove any herbal product which hasn't had a proven track record in the E.U. Meanwhile, the Pharmaceuticals Directive seeks to expand the scope of the drug classification and in its current wording even food or water can be included as a substance which- and I quote; restores, corrects, or modifies physiological functions!

Heather: It's frightening stuff, but luckily there

allow natural substances to be available if there is no evidence of serious side effects/ contraindications. We must not allow the pendulum to swing completely the other way, otherwise the only offering will be drugs- because they are the only ones that can afford to have trials run on them, and that's due to the fact that drugs can be patented and therefore have high profit margins etc.

Still, we digress into politics!

Heather: It's a necessary evil.

AAM: I did notice with interest that you have split your operation into two different parts, one for internal antiaging medicine, the other for external. How has that helped you?

Heather: Typically most people thinkincorrectly- of antiaging medicine as a branch of aesthetic medicine. In other words 'external' beautifying treatments, perhaps not necessarily of a cosmetic nature. Whereas 'internal' antiaging medicine is the more long-term, dare I say, 'serious' end of the spectrum, where we seek to slow down, arrest and hopefully reverse the aging process. It's not often that clients come in for both types at the same time, so our spa and clinic facilities have been separated to cater specially for each particular requirement.

AAM: What do you offer for external treatments?

Heather: Various skin creams, including CoQ10, face peels, massage, acupuncture, mud packs, laser therapies and of course Botox and other fillers.

AAM: And what do you offer for internal antiaging treatments?

are many active groups like the Alliance for

Heather: We offer the natural bio-identical

Natural Health [Ed.- www.alliance-natural-

hormones such as; DHEA, human growth

health.org also the UK Conservative Party is

hormone, estrogens, progesterone, melatonin

compiling a petition see:

and thyroid etc. But we also offer a wide range

http://www.conservatives.com/vitamins] and

of nutrition, including the Beyond Chelation

professional people like Dr. Mathus Rath, who are all presenting cases against these ridiculous regulations. We all need to lend them our full support and make sure that the public are aware of the erosion of their rights to choose for themselves.

AAM: I agree, after all if allowed to continue- the banning of over-thecounter natural medicine will create a two tier planetary health system. Plus, as the E.U. laws are imposed in other countries under World Trade Organization 'harmonization' rules- that includes America. I believe Europe needs a DHSEA like America, we need to put the boot on the other foot and

FAX O R D E R I N G +44 (0)208 181 6106

range as we are very aware of the damage that pollutants and toxins can do. In addition,

who wants to undergo an examination for antiaging medicine?

Heather: Their first consultation will be with our nutritionist and doctor. This includes a comprehensive questionnaire of the patient's medical history, along with their family background. We also determine what the patient wants to achieve, whether that be weight loss, better skin condition or the avoidance of a disease etc. That often comes as a result of seeing a close friend or relative

we have several specialized brain nutrition

with the same problem. A consultation can

products- the smart drugs and other cutting-

also be arranged with our Medical Doctor,

edge antiaging therapies such as the Can-C

Lynette Yong, she guides them through other,

eye-drops.

perhaps 'stronger' options and makes them

AAM: I'd like to ask- as a percentage, how many women to men take up the external treatments, and how does that differ with the internal treatments?

aware of various concepts and issues in

Heather: External treatments are as you might imagine requested by about 70% women and

antiaging medicine. As a big part of the equation is education, patients need to understand why they are doing certain things and why they need to stick to them. As a slow degenerative multi-faceted complaint, aging is so broad that sometimes it's hard to know

30% men. That figure reverses when it comes

where to start.

to internal therapies.

AAM: what techniques do you use to enable the patient to focus on his/her main aging problem areas m

AAM: Please tell us, what's a typical procedure for someone

19

Heather: One of our principle diagnostic tools

the time. People need to understand that

something like the 'C' word is uttered. We

is Inner-Age. This is a comprehensive test of

antiaging medicine is principally about not

must continually educate people to the

approximately 30 physical parameters, and up

getting sick, not being dependant upon others,

possibilities and the options open to them.

to 100 blood measurements that can assess

and remaining physically active, lucid and

One of the major efforts I am involved in is the

the patient against the average in the

agile throughout a long life. An old biological

London Antiaging Conference, with that

community. The Inner-Age report uses simple

age means you are more likely to suffer with

vehicle I hope that we can enlighten people to

colors laid over a body map to identify which

illness and disease before others of your

understand the difference between what we

areas of the body are aging faster than the

same chronological age group. If you know

are doing in antiaging medicine and what

norm. As a result, we find that the average

that, you can do something about it.

mainstream medicine does.

patient can focus on the areas of greatest

AAM: Also it's remarkable to me that some people have told me that they'd rather not know about their health condition! I've always thought that's like not bothering to put road signs up that say the bridge is out ahead! Instead let's just drive over it and plummet into the river! At least it will be quickhopefully...

AAM: Yes indeed- please tell us a bit more about the next London Antiaging Conference.

concern, and over a period of months can make adjustments and changes to their lifestyle and health program. When they are retested, they can see for themselves if what they have been doing has worked for them, and in the majority of cases it does. Then the patient understands the processes involved much better and most important of all- sticks to doing it regularly!

AAM: That's an important point.

I've met people who say; what's the point in knowing how biologically old you are? I suppose they only say that because they don't understand that they can alter the outcome. In other words, they can focus on the biologically older parts of their bodies and make themselves biologically younger.

Heather: It is due to take place at the Royal College of Physicians on May 7-8,2005. Full details can be seen at www.antiageingconference.com

major, costly and debilitating treatment once

AAM: Congratulations on all your efforts Heather. I can't imagine how you fit it all into your busy workload and hectic lifestyle that I know you have. Well done is all I can think of right now!

every 5 or 10 years, why not do a little every

Heather: Thank you Phil. We've all got to keep

Heather: There's a lot of misconception of what antiaging medicine is. Rather than a

few months and stay on the course of optimal

banging-on-the-drum so that more people

health? At-the-end-of-the-day, it's far easier

wake up to the realization that antiaging

and cheaper, but I suppose there are people

medicine is the next generation of medicine in

out there who can't see what they are paying

the 21st century. It is available now to make

for when it comes to preventative medicine,

people's lives, particularly in their latter years

then all-to-often they are prepared to do and

easier, more comfortable and more enjoyable.

pay anything and everything the moment

AAM: Hear Hear! •

Heather: Indeed they can, and we see it all

i in* wwi •

Become

IAS o f f e r a w i d e v a r i e t y o f o p p o r t u n t i e s t o companies and individuals i n t e r e s t e d in e n t e r i n g i n t o t h e f i e l d o f ^

antiaging medicine.

For f u l l d e t a i l s of o u r p a r t n e r s h i p s c h e m e s p l e a s e c o n t a c t t h e IAS b u s i n e s s d e v e l o p m e n t t e a m a t

richard@antiaging-systems.com

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volt

Send your questions, letters & comments to: Editor, Antiaging Magazine, Beckett House, 14 Billing Road, Northampton, Great Britain or via e-mail: editor@antiaging-magazine.com

the day it is a personal choice.

Phil Micans, PharmB What has happened to the original Romanian made GerovitalH3?

LETTER OF T H E M O N T H I've heard that Allergen are about to launch a product called Prevage ©which is being heralded as a great new skin care product. What is its active ingredient?

Prevage ® will contain Idebenone, which has been available through IAS for the last 8-years. Idebenone is quite simply the most potent antioxidant known to us, which probably accounts for its beneficial action on skin. However when Idebenone is taken orally it is known to have many benefits including increasing serotonin and nerve growth factor levels and protecting against ischmeia, (reduced blood flow). Born of CoQ10, Idebenone does more than that popular supplement.

Phil Micans, PharmB

Which is the best form of deprenyl to use?

On paper the 5mg tablets are better value, and if high dosages of deprenyl are required, (i.e. as in Parkinson's disease), then the tablets make better economic sense. The tablets are in a hydrochloride base (an inorganic molecule) and due to the nature of tablets also contain fillers. In comparison the liquid is in a citrate base (an organic molecule) and small does of the liquid can be titrated, (e.g. 1 drop equals 1 mg.) This makes the liquid preferable for antiaging purposes where maybe only 1 to 3 mg. are required. But our experience tells us that many physicians and patients prefer the liquid version once tried over-the tablets. At the end of FAX ORDERING +44 (0)208 181 6106

There has been a dispute between the manufacturers of Gerovital-H3 ® and the Romanian government that effectively stopped production/ export of the original Gerovital-H3. At the time of this magazine going to press, and despite rumors to the contrary, this issue had still not been resolved; although we are hoping it will be soon and that we will be able to offer our customers this product once again.

Until this issue is resolved we continue to stock our generic GH3-Pro version as an alternative.

Phil Micans, PharmB Why should I choose the liquid Hydergine over the tablets?

There are two answers to this question. Firstly, if you want to take low dosages of Hydergine, then you can titrate as little as half a milligram with the liquid, whereas a quarter of a Hydergine tablet is equal to 1.125 mg.

Secondly in rare cases the tablets can cause a stomach upset, which is less likely to occur with the liquid as some of the product is absorbed sublingual^.

Phil Micans, PharmB Can you advise me on the concurrent use of my existing drug and one of your products?"

being taken, medical and family history, hypersensitivity, allergies and current condition etc. All of which means that only a personal physician can give direct advice. However, we can check with the manufacturers and clinical trials information to make sure there is no known direct and obvious contraindication between the products themselves.

Phil Micans, PharmB I very much enjoyed your Winter 2004 issue about the body's burdens. What do you recommend as a cover-all chelation program?

We recommend that everyone takes at least one sachet of the Beyond Chelation Improved ® (BCI) every morning. If for some reason you don't want to give up your current multivitamins, then just take the 3 of the Essential Daily Defense ®, which are the chelation capsules contained within the BCI. In addition we strongly recommend 1 to 3 teaspoons of Beyond C ® daily, (equivalent to 3 to 9 grams). When bathing use a scoop of Beyond Clean ® in the bath, and if mercury is considered to be a particular problem, (especially of you have dental work), then chew an EZ Defense ® gum after each meal.

Finally, take 1 or 2 capsules of Heavy Detox ® before bedtime. Keep this up and after several weeks you should feel the difference (perhaps much sooner), but remember what Dr. Gordon pointed out in his interviewchelation is a lifelong endevour because the accumulation of metals and toxins occurs through the everyday normal practices of eating, drinking and bathing.

Phil Micans, PharmB

This is a question we are often asked and it is very difficult to answer for many reasons. Consider that apart from a known/ reported interaction between product X and Y that the following information needs to be known: sex, bodyweight, dosages of all products

W R I T E & WIN! If your letter is published you will recieve a copy of 'Millenium Guide to Antiaging Medicine' worth $29.95 absolutley free!

We will try and reply to all letters we recieve and answer as many of questions as possible.

21

Beyond Chelation Improved Much more than a multi-vitamin

Not only does Beyond Chelation Improved (BCI) do everything your current multi-vitamin does, it also offers you unique chelating ingredients to guard against toxic elements such as heavy metals like lead and mercury to which we are all constantly exposed. The power of oral chelation combined with Vitamin K 2, Resveratrol, the purest omega oils available and many other of the finest ingredients provide the basis for attaining optimal health.

BCI consists of 5 high purity products, each designed to target specific areas of health, to enable you to enjoy the most comprehensive and easy-to-use nutritional supplement available anywhere. Make BCI your choice every morning, all of the following are contained in convenient sachets- there are no multiple bottles to be opened!

BCI saves you time and money- by making it cost effective and easy for you to cover the major nutritional bases daily.

Please turn to page 35 and read about the BCI special offer we arc running for a limited period exclusively for readers of International Antiaging Magazine.

www.antiaging-magazine.com 22

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Anti-depression is a phrase recognised by everyone, and many people at sometime in their life come into contact with anti-depressants. But all too often "mainstream" medicine looks for a simplistic approach, knowing that often the brain chemical serotonin is lacking, and so drugs such as Prozac are prescribed, which for many people is highly effective. But there are many other reasons why people may be depressed, and these can include other neurotransmitter imbalances, brain energy itself (a lack of oxygen, glucose uptake or blood circulation), and even a lack of specific hormones. There are a number of different approaches for this condition and we offer some of the class leading products below.

Milnacipran - brand name Ixel is being heralded as a 'miraculous treatment' in the fight against Fibromyalgia and Lupus.

It is believed that the combination of Milnacipran's norepinephrine and serotonin enhancement action has pain-killing, mood lightening and calming effects. Therefore, Milnacipran is also a wonderful new weapon in the fight against both depression and pain.

As the precursor to Serotonin, 5HTP has many similar uses compared to LTryptophan, such as the assistance of sleep and alleviation of age-related mental depression, as well as alcohol withdrawal.

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GH3Pro is a generic Gerovital-H3. It improves cell metabolism, concentration and vitality, alleviates joint stiffness, enhances well-being and acts as an anti-depressant. It is even known to boost skin and hair condition.

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L-Tryptophan is an essential amino acid and its uses include alleviating depression, alcohol withdrawal and aiding weight loss. This product is the German pharmaceutical grade L-Tryptophan.

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the original antiaging supplement

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SAMe - brand name Samyr has been described as the day-time alertness hormone, having a major role in the production of the universal energy life molecule, ATP. SAMe is the third most concentrated chemical in the liver, so it has been widely used to correct liver disorders such as cirrhosis and even hepatitis. It is also an excellent antidepressant.

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56 x 25mg capsules from $44.95 Reboxetine - brand name Davedax is the equivalent of Edronax. It is a new and unique anti-depressant that works by allowing the brain to have more of the stimulatory brain chemical norepinephrine (a neurotransmitter, the deficiency of which is believed to be one of the causes of depression).

60 x 4mg tablets from $62.95

Stablon is a drug that actively fights depression by increasing the brain's uptake of serotonin. This anti-depressant is particularly effective as it does not normally cause drowsiness or interfere with the libido.

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The thyroid gland is an endocrine gland located in the neck, that is involved with temperature regulation and many other vital roles, including the immune system.

Supplements are also known to improve sleep patterns for many people. Thyroid is also known to assist some people in well-being and positive outlook.

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23

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At any given time, about 10 percent of the hair on your scalp is in a resting phase.

After 2 to 3 months, the resting hair falls out and new hair starts to grow in its place. This growing phase lasts for 2 to 6 years. Each hair grows approximately 1 centimeter per month during this phase. About 90 percent of the hair on your scalp is growing at any one time. It is normal to shed some hair each day as part of this cycle. However, some people may experience excessive (more than normal) hair loss.

Anti-Aging Directory This topical lotion is applied to the scalp to promote and stimulate new hair growth. Minsaw-A contains a solution of minoxidil at a super high strength of 7%, combined with retinolic acid at 0.025% and Saw Palmetto at 3%. Minoxidil is well known as a improver of blood supply to the hair root and has been in safe use for over 20-years.

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Dutasteride is the most potent DHT blocking product currently available, either for Prostate conditions, or hair loss.

Dutasteride prevents testosterone becoming DHT (di-hydro-testosterone), by blocking an enzyme that converts it called; 5-alpha-reductase. It should be noted that all 5-alpha reductase inhibitors MUST not be handled or used by women.

Avodart'

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30 x 0.5mg capsules from $67.45 Finasteride belongs to a group of drugs known as 5-alpha reductase inhibitors.

This enzyme normally "acts" upon testosterone and converts it to the hormone DHT. High DHT levels contribute

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Nizoral shampoo contains ketoconazole and is a potent anti-dandruff shampoo that appears to actually help prevent hair loss.One reason may be that Nizoral helps to block the conversion of testosterone to dihydrotestosterone (DHT). It is believed that DHT has a role in the hair follicle dying and falling out.

shampoo

Dercos contains the chemical Aminexil and is designed to stop hair loss by preventing perifollicular fibrosis. This is a condition that accompanies all alopecia whereby the collagen around the root becomes rigid and tightens, pushing the root to the surface and causing premature hair loss. Dercos is available in either Shampoo or Ampoules.

DERCOS

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Sleep Regular good sleep is so important and yet overlooked by so many people. Deep sleep is a process by which our neurons repair themselves and gather the resources they need for another active day. Everyone knows that when sleep is deprived, a person goes "downhill" rapidly. Yet with aging we all lose the ability to sleep well, so enhancement of quality sleep is essential as we get older.

Conversely, there can also be too much sleep, or inopportune moments when sleep is not required (i.e. during the day- a condition known as narcolepsy). There are a number of different approaches for these problems and we offer some of the class leading products below.

Melatonin - brand name Tl-Melatonin is directly involved with sleep regulation, so the supplement's use in the treatment of age-related sleep disorders, jet lag or shift work is impressive. There is also some evidence that melatonin boosts immune system function, lowers cholesterol in people with high levels, and may be useful in treating or preventing cancer.

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L-Tryptophan is an essential amino acid and its uses include alleviating depression, alcohol withdrawal and aiding weight loss. This product is the German pharmaceutical grade L-Tryptophan.

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Modafinil is a remarkable, unique drug because it offers stimulation without affecting sleep. It provides 'good arousal'.

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s Adrafinil - brand name Olmifon is the world's first stimulant and antidepressant that enhances mental clarity, alertness and awareness without impeding our normal sleeping patterns or making us anxious and agitated.

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The thyroid gland is an endocrine gland, located in the neck, that is involved with temperature regulation and many other vital roles, including the immune system.

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Centrophenoxine (formerly known as Lucidril) increases the brain's use of glucose and improves brain energy levels. It also removes a potassium build up in the brain, heart, lung and skin cells, and is vital for the efficient communication of a cell to transfer potassium and sodium across its membranes. Centrophenoxine improves concentration.

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Modafinil is a remarkable, unique drug because it offers stimulation without affecting sleep. It provides 'good arousal'.

We carry two brands of Modafinil, ProVigil and Modiodal although both products are identical and are licensed by the same pharmaceutical company.

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Adrafinil - brand name Olmifon is the world's first stimulant and antidepressant that enhances mental clarity, alertness and awareness without impeding our normal sleeping patterns or making us anxious and agitated.

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Desmopressin, (brand name Minirin), was formerly known as Vasopressin. It is a peptide that is believed to deposit memories into the hippocampus as they are learnt. As such, used as a nasal spray it is very fast acting to improve memory imprinting and short term memory, in some countries it is even used to treat amnesia.

Desmopressin is seen as an ideal agent for conferences and lectures etc

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Brand name Ampamet, this was the first Nootropic developed from Piracetam. It is virtually non-toxic and has beneficial effects in the treatment of memory loss, age related memory decline and lack of concentration. Aniracetam can improve memory recall, reaction speed and detail.

20 x 750mg tablets from $44.95 O R D E R I N G www.antiaging-magazine.com

Skin Care The skin is often known as "the largest organ in the human body": this does not only (obviously) apply with regard to surface area, but also with regard to weight, as it weighs more than any single internal organ. The skin on a person's face is seen by people that person interacts with. For some people, then, facial skin care is of importance, and cosmetics are made to deal with the appearance of the person's face and condition of the skin, such as pore control and blackhead cleansing. As skin ages is becomes thinner and more easily damaged. Intensifying this effect is the decreasing ability of skin to heal itself. Skin sagging is caused by the fall in elasticity. Skin also receives less blood flow and lower gland activity In medicine, the branch concerned with the skin is called dermatology.

Our Carnosine serum can be applied to clean dry skin on a regular basis and should help prevent the appearance of tough, leathery skin, as well as reduce fine lines and discoloration. Carnosine is a potent late stage inhibitor of glycosylation, the process of protein cross-linking that over time, and with exposure to sunlight and pollution etc., causes the skin to change.

30ml bottle $49.95

Formerly known as Lucidril, Centrophenoxine removes a potassium build up in the brain, heart, lungs and skin cells called lipofuscin, which in skin are often called age-spots or liver-spots, over several weeks these can be seen to be reduced. In addition, Centrophenoxine increases the watery content of cells which may also improve skin condition.

Item Code: 0199

As Melatonin is the most potent antioxidant in nature, it protects the skin against the ravages of free radical attach that is known to accelerate aging. Our unique topical Melatonin cream has been shown to reduce the depth of wrinkles after only 1-month of treatment. It can also make the skin smoother to the touch and enhance its appearance. It is also a superb after-sun treatment.

Professor John lonescu is one of Europe's leading dermatologists. Energy cream is the result of his work to reduce and remove skin blemishes such as psoriasis, eczema and acne. It contains natural ingredients such as ATP and ADP to stimulate and improve the skin's energy processes, so that it can heal itself faster and more efficiently.

50ml cream $59.95

Item Code: 0371

Professor. John lonescu's unique skin cream is a special combination of ingredients developed from his research and published science. It delivers a rapid uptake of ingredients into the epidermis cells via a patented DMS nanoparticle technology. Energo smoothes the skin around the eyes and fights against dark circles and puffiness, nourishing and toning providing the skin.

50ml cream $84.50

FAX

O R D E R I N G +44 (0)208 I8I 6106

100ml bottle $39.95

Item Code: 0243

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Item Code: 0304

Containing the RNAs of the skin (ribonucleic acids are the building blocks of DNA), CoQ10 and vitamin E, the combined effects of NeySkin CoQ10 enhance blood circulation and increase collagen and elastin production. The skin is better supplied with nutrients and oxygen and the removal of metabolic waste is enhanced. NeySkin CoQ10 is an excellent moisturizer.

Item Code: 0298

Another unique cream from the work of Professor John lonescu. Not only does Solaris have a SPF of 25 to guard against photoaging, but it also allows tanning to take place. Thus giving the look that people want with6ut the damage. Solaris combines double UVA and UVB protection with melanin promoting factors to enhance the natural tanning process.

150ml cream $49.95

60 x 250mg capsules from $26.95

CentrophenoxiM

50ml tube cream from $31.45 Retin-A is a treatment for acne and black spots, yet it displays a remarkable talent to remove wrinkles and improve skin condition. Retin-A can reduce severe wrinkles within a mere 6-weeks and remove fine lines. It does this by improving the blood supply to the skin and by increasing the turnover of dead cells and consequently, new younger looking skin appears at the surface.

Item Code: 0300

30ml 0.100% tube from $26.95

Item Code: 0047

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Item Code: 0074 27

Antiaging & Longevity Of course many products and protocols can be described as antiaging, and a few can even point to their longevity (life extension) properties (at least in animals).

Our category here focuses upon products that have been scientifically proven to readjust key parameters that are often at the core of pro-aging (if left unchecked).

In other words, they have benefits to slow and reverse particular signs of age and its degeneration on a broad and general level in the body. There are a number of different approaches for this condition and we offer some of the class leading products below.

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NeyGeront is a German produced RNA extract (ribonucleic acids are the building blocks of DNA). Designed to help the organs most affected by stress, wear and aging, these RNAs from the heart, thymus, gonads, liver, pancreas and other glands, in fact thirteen in total. Also contained in the capsules are vitamins B6, B12 and E, as well as procaine, biolecthins and amino-acid complexes.

Desmopressin, (brand name Minirin), was formerly known as Vasopressin. It is a peptide that is believed to deposit memories into the hippocampus as they are learnt. As such, used as a nasal spray it is very fast acting to improve memory imprinting and short term memory, in some countries it is even used to treat amnesia.

Desmopressin is seen as an ideal agent for conferences and lectures etc

Item Code: 0229

Item Code: 0321

40 x 0.5 capsules from $44.95

L-Cornosim

Carnosine - brand name L-Carnosine is a powerful anti-oxidant, Carnosine not only flushes toxins out of the body, and it also boosts the immune system so that we are better equipped for fighting off disease. Carnosine also helps improve the function of the heart, protects against radiation damage and exerts anti-cancer effects.

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Item Code: 0171

60 x 50mg capsules from $14.95

Item Code: 0032

Centrophenoxim

Centrophenoxine (formerly known as Lucidril) increases the brain's use of glucose and improves brain energy levels. It also removes a potassium build up in the brain, heart, lung and skin cells, and is vital for the efficient communication of a cell to transfer potassium and sodium across its membranes. Centrophenoxine has shown an ability to remove liver spots.

Item Code: 0243

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Selepryl

Item Code: 0239

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60 x 250mg capsules from $26.95

Deprenyl liquid - brand name Selepryl protects and enhances mental function, mood and even libido by increasing brain levels of the focus and drive neurotransmitter- dopamine.

300mg bottle $65.00

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2.5ml nasal spray from $23.35 Hydergine - Brand name Hydergina enhances mental abilities by improving and stabilizing oxygen supply to the brain. Hydergine is also known to improve mitochondrial condition, which as the energy producing cells throughout the body has a wide antiaging benefitThis pharmaceutical grade Hydergine is made by Novartis, the company formerly known as Sandoz.

30 x 4.5mg tablets from $20.65

: g^S GH3Pro is a generic Gerovital-H3. It improves cell metabolism, concentration and vitality, alleviates joint stiffness, enhances well-being and acts as an anti-depressant. It is even known to boost skin and hair condition.

th® o r i g i n a l antiaging supplement

Item Code: 0360

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60 x 10Omg tablets from $17.95 Melatonin - brand name Tl-Melatonin is directly involved with sleep regulation, so the supplement's use in the treatment of age-related sleep disorders, jet lag or shift work is impressive. There is also some evidence that melatonin boosts immune system function, lowers cholesterol in people with high levels, and may be useful in treating or preventing cancer by assiting in the rebalance of hormones.

60 x 3mg tablets from $13.45 O R D E R I N G www.antiaging-magazine.com

Memory & Cognition

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Who are we without our minds? You may be body beautiful, but stimulating conversation and interesting anecdotes are the result of a sharp mind and good mental abilities, and it is these facilities that make us interesting individuals and give us our personalities. There are many facets to memory and cognition, and through the unique range of products that IAS has supplied over the years, and the scientific, professional articles we have published, (all based on clinical evidence) has made this range our consistent best sellers. There are a number of different approaches for this condition and we offer some of the class leading products below.

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Centrophenoxine (formerly known as Lucidril) increases the brain's use of glucose and improves brain energy levels. It also removes a potassium build up in the brain, heart, lung and skin cells, and is vital for the efficient communication of a cell to transfer potassium and sodium across its membranes. Centrophenoxine improves the speed of memory recall.

60 x 250mg capsules from $26.95

4 Centrophenoxine

Item Code: 0243

Hydergine - brand name Hydergina enhances mental abilities by improving and stabilizing oxygen supply to the brain. This pharmaceutical grade Hydergine is made by Novartis, the company formerly known as Sandoz.

40ml liquid bottle from $11.65 Aniracetam - brand name Ampamet is the first Nootropic analogue developed from Piracetam. It is virtually non-toxic and has beneficial effects in the treatment of memory loss, age related memory decline and lack of concentration. Aniracetam can improve memory recall, reaction, and detail.

20 x 750mg tablets from $44.95

Galantamine - brand name Reminyl is available in liquid form and used as a front line treatment for Alzheimer's disease. Galantamine stimulates nicotine receptors and also improves levels of Acetylcholine.

400mg liquid $149.95 FAX

O R D E R I N G +44 (0)208 I 8 I 6106

Memantine - brand name Ebixa is a novel new drug that is showing a lot of promise in the battle against Alzheimer's disease, and is now available in liquid form. Some studies indicate that Ebixa could be effective for Parkinson's disease, while others suggest that Ebixa and NMDA receptors may have a role in alcoholism and that Ebixa could act as an anti-craving drug for alcohol.

Hydetgna

500mg liquid $179.95

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Pregnenolone supplements can help to improve energy levels and combat chronic fatigue, and is also particularly helpful against the swelling and inflammation associated with arthritis, having been used to treat arthritis since the 1940's. Other benefits of the Pregnenolone supplement include stress reduction. Pregnenolone is the most potent memory enhancing sterone.

50 x 5mg tablets from $13.45

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50 x 100mg capsules from $17.95 Vinpocetine brand name Intelectol, improves brain blood flow its unique quality is that it only affects areas that need to be improved. Intelectol has been shown to help improve hearing (particularly tinnitus), eyesight, and even to alleviate the problems involved with menopause.

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Item Code: 0205

60 x 800mg tablets from $19.75

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Item Code: 0320

Piracetam - brand name Nootropil is made by UCB and is the world's best selling so-called smart drug. It helps with learning and appears to be a substance capable of extending the intellectual functions of man, even individuals already gifted with high intelligence and good memory.

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Ampamet 750

Ebixa

Item Code: 0335

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Nutrition & Vitamins Good sound nutrition forms the base of any optimal health i j ^ H b d is the position to build from, adding additional specialist products, 1 liter they be specialised nutrition, hormones or drugs, and collectively thHJBBbiprove the overall health and strength of the individual. We choose our nUtl|ohal products carefully, ensuring that quality and source of ingredients, as well as the synergistic properties of the formula are balanced a n ( H f l | f i to be efficacious. In other words, we are so confident of them, these a r e f l H b m e products that our families rely

Anti-Aging Directory Beyond C contains the purest form of L-ascorbic acid, but it is much more than "just" vitamin C. A unique bonding called FASM, enables high dosages to be used without side effects such as stomach upset. Furthermore, the addition of Ribose and MSM ensures that energy levels are boosted and intracellular delivery of nutrients are improved.

Item Code: 0350

200g p o w d e r $39.95 Beyond GHS is a proprietary combination of the most powerful Growth Hormone (GH) Secretagogues known, plus a cutting-edge herbal complex designed to maximize IGF-1 output and anabolic effect. Made from completely natural ingredients, this special growth hormone release supplement is a combination of natural compounds, amino acids and herbs to improve both GH and testosterone output.

Item Code: 0353

BC I Beyon Chela ti Improved j

Item Code: 0351 30

75 t a b l e t s $79.95

Endozym Med is a clinically proven, natural systemic enzyme supplement that eases joint discomfort while also promoting better blood circulation. An exclusively plant-based it is the next generation of scientifically corroborated systemic enzymes to promote smoother blood flow and ease age-related joint discomfort and swelling. Contains Nattokinase, Bromelain, Papain, Rutin and White Willow Bark.

Endozym MM),

Item Code: 0354

Immuni-T'

240 t a b l e t s $68.95 lmmuni-T3 provides 12 active ingredients to enhance immune system functioning.

It is the world's most comprehensive immune support product, with strong transfer factor levels, ad includes mushroom extracts, oil of oregano, Aloe Vera, Astragalus, liquorice root, zinc and a unique supernatant from cultures of Bifidus based on the Ayurvedic natural antibiotic concept of NEEM.

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Item C o d e : 0358

60 c a p s u l e s $62.95 Maca is a powerful adaptogen, which means to say it is a plant substance capable of balancing and normalizing many of the body's systems. Thus Maca has been used to reduce stress, harmonize vitality, and enhance resistance to disease. Used by South American Indians for thousands of years, they considered Maca to be a sacred plant because of the diversity of its benefits.

As the foundation nutritional product in our range, BCI contains 3 Beyond Vitamin tablets each containing 36 nutrients, including vitamin K2 and resveratrol (rarely seen in multiples). 3 additional Chelation capsules, Essential Daily Defense are also included (please see same for details). Plus there is an Omega 3 capsule, along with a Primrose oil capsule containing Omega 6, 9 and GLA. Finally a capsule of gingko biloba and phosphatidylserine is included for brain health. All these capsules are contained within a sachet, so that all is ready to be taken without fuss first thing in the morning with breakfast. Designed

by Dr. Garry Gordon, we are impressed by the quality, synergy and convenience of this product and recommend it for everyone.

Item C o d e : 0359

30 Sachets (9 Capsules in each) $52.95

Item C o d e : 0325

180 x 5 0 0 m g c a p s u l e s $24.95 f oly-MVA' unique combination of minerals, vitamins and amino-acids supports cellular energy production and replace key nutrients, (particularly those that may be depleted during chemotherapy and radiation). With its unique addition of palladium, it is designed to provide energy for the body's systems by changing the electrical potential of cells and increasing the charge density of DNA within the cell.

ONLINE

4 o z l i q u i d b o t t l e $129.95 ORDERING

www.antiaging-magazine.com

Chelation & Detox Chelation is the removal of heavy metals from the body, necessary because the accumulation of heavy metals such as lead, mercury, aluminium, arsenic and cadmium etc., can cause a wide range of differing disorders- from fatigue to Alzheimer's disease, all dependant upon where the accumulation has taken place and its severity. Many people now consider Chelation, and other forms of detoxification, (to reduce "parasites" and reduce the body's burdens) as a cornerstone for optimal health and antiaging medicine.

EDD is Dr. Garry Gordon's premier oral chelation capsule, containing a mix of potent chelating agents to eradicate the widest possible cross-section of heavy metals including lead, mercury and cadmium etc. EDD contains Allicin, EDTA, Malic acid, Methione and 10 other synergistic ingredients and is a core chelation product.

Artemisinin is also known as Wormwood, and it has been used for thousands of years as a worm treatment, but it also is a potent eradicator of "flukes" and other parasites, including yeasts that infest the body. Artemisinin is also used in "alternative" cancer treatments and malaria.

90 x 100mg capsules $49.95

Item Code: 0349

Item Code: 0350

Now for the first time healthy bathing is possible! Beyond Clean contains EDTA bath salts that bind to the metals in your house water, and also help to bind to metals in your skin. The outcome is that bath water is softened and the skin is chelated of heavy metals, slowing skin aging. Simply add a scoop to your next bath.

20oz powder $39.95 L-Carnosine is noted for its broad spectrum of antiaging benefits, including being a potent inhibitor of glycation, a process whereby proteins become impaired, because they cross link in the presence of oxygen and glucose.

However, what it not so well known is that L-Carnosine is a potent chelator of copper.

60 x 50mg capsules from $14.35 FAX ORDERING +44 (0)208 I8I 6106

Item Code: 0355

Another unique product formulated by world chelation expert, Dr. Garry Gordon.

This pleasant orange tasting chewing gum contains EDTA to specifically help remove heavy metals from the mouth.

Chew after meals and discard once the flavor has gone, knowing that you are removing mercury and other metals from your gums.

Beyond C contains the purest form of L-ascorbic acid, but it is much more than "just" vitamin C. A unique bonding called FASM, enables high dosages to be used without side effects such as stomach upset. Furthermore, the addition of Ribose and MSM ensures that energy levels are boosted and intracellular delivery of nutrients are improved.

200g powder $39.95

100 capsules $24.95

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100 tablets $24.95

Item Code: 0356

This product has been designed for those with more serious heavy metal issues, in particular mercury contamination. Containing Succinic acid, Glucuronolactone and 2 differing forms of selenium, Heavy Detox is the strongest oral form of chelation on the market. 1 to 3 capsules can be taken at night time.

Item Code: 0352

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45 capsules $48.95

ar-KOSmi L-Cc

Containing high strengths of both forms of the proven estrogen reducing agents, DIM (di-indolylmethane) and I3C (indole3-carbinol), 60 mg and 200 mg per capsule respectively, Pro-Brassica increases the eradication of estrogens.

Necessary, because estrogens have now leaked into and become prevalent in our everyday lives.

Item Code: 0171

60 x 260mg capsules from $31.45

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Item Code: 0357

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Item Code: 0338 3I

International Antiaging Systems (IAS) Product Order Guide

1 SPECIAL OFFER | Pack Price

Quantity

Product 5HTP (Oxitriptan) Acarbose (Glucobay)

4-Pack discount

Item Code 0327

60 X 50mg capsules #

$14.95

10%

30 x 1 OOmg tablets E l

$19.95

10%

0373 0329

Acetyl-L-Carnitine

50 x 5OOmg capsules

$24.95

10%

Adrafinil (Olmifon)

40 x 3OOmg tablets E l

$34.95

10%

0052

$29.95

10%

0303

$19.95

10%

0163

10%

0006

Aminoguanidine

100 x 75mg tablets #

Anacervix

30 x 420mg capsules

Aniracetam (Ampamet)

20 x 750mg tablets E l

$49.95

Aricept

28 x 1 Omg tablets E l

$159.95

0374

Arimidex (Anastrozole)

28 x 1 mg tablets E l

$199.95

0111

Artemisinin

90 x 1 OOmg capsules

$45.95

Benfotiamine (Milgamma Mono)

30 x 50mg tablets

$17.95

Beyond C

200g powder

$39.95

0350

Beyond Chelation Improved

30 sachets

$52.95

0351

Beyond Clean

20oz powder

$39.95

0352

Beyond GHS

75 tablets

$79.95

Bio-Pro

30ml 640mg bottle

$34.95

10%

021 1

16 x 1 mo tablets E l

$29.95

10%

0008

30 x 2.5mg tablets E l

$19.95

10%

Can-C (N-acetylcarnosine eye-drops)

5 x 2ml vials

$39.95

10%

•H0222

Carnosine (L-carnosine)

60 x 50mg capsules

$15.95

10%

0171

Carnosine (Topical Beta Alistine)

30ml serum bottle

$49.95

Centrophenoxine

60 x 250mg capsules #

$29.95

Cialis (Tadalafil)

4 x 20mg tablets E l

$74.95

Ciproxin (Ciprofloxacin)

6 x 500mg tablets E l

$29.95

10%

0263

Conjunctisan A Eye-drops

20 x 0.5ml vial #

$34.95

10%

0013

Conjunctisan B Eye-drops

20 x 0.5ml vial #

$34.95

10%

0014

NeySkin C o Q 10

50ml tube cream

$34.95

10%

0047

Deprenyl (Selepryl)

1 2ml / 3OOmg liquid bottle E K »

$69.95

Deprenyl (Jumex)

50 x 5mg tablets E l *

Dercos (Aminexil / Topical)

200ml shampoo bottle

$19.95

10%

0017

Dercos (Topical / Aminexil)

18 x 1.5% ampoules

$69.95

10%

0183

Desmopressin (Minirin)

2.5ml nasal spray E l

$25.95

10%

0229

DHEA (7-keto)

90 x 25mg capsules E l *

$22.95

10%

0210

DHEA (Micronized)

60 x 25mg capsules E K *

$9.95

10%

0330

50 x 50mg capsules E K -

$14.95

10%

0331

(ATP & N A D H Sublingual)

Biostim Bromocriptine (Parlodel)

DHEA (Micronized)

0

0349 10%

0273

0353

0058

0199 10%

0243 0296

0239 10%

0035

DHEA (Sublingual / Pro-Cell)

14ml liquid bottle E K »

$44.95

10%

0157

DIM (Pro-Brassica) Estrogen Blocker

60 x 260mg capsules

$34.95

10%

0338

Doxycycline

8 x 1 OOmg capsules E l

$19.95

10%

0164

Dutasteride (Avodart)

30 x 0.5mg capsules E l

$74.95

10%

0276

Efexor (Venlafaxine)

28 x 37.5mg tablets E l

$39.95

10%

0234

Endozym Med

240 tablets

$68.95

0354

Energo

50ml cream bottle

$84.95

0298

Energy

50ml cream bottle

$59.95

0371

Essential Daily Defense

100 capsules

$24.95

Estrogen Natural (Esnatri)

50ml jar cream E l

$49.95

EZ Defense Detox Gum

100 tablets

$24.95

Femara (Letrozole)

14 x 2.5mg tablets E l

$149.95

Fluconazole (Loitin/Diflucan)

7 x 50mg tablets E l

$39.95

Fosamax (Alendronate)

1 4 x 1 Omg tablets E l

$34.95

Galantamine (Reminyl)

56 x 4mg tablets E l

$124.95

0316

Galantamine (Reminyl)

100ml 400mg liquid bottle E l

$149.95

0319

Gamalate B6

60 x 250mg tablets

$9.95

El • # 32

0355 10%

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10%

0307 0332

10%

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Products marked with this symbol can not be shipped to the EU. Products marked with this symbol are restricted in certain countries. Please see website for full details.

Products marked with this symbol can not be shipped to the UK.

ONLINE

ORDERING www.antiaging-magazine.com

IAS Product Order Guide - Page 2

| Pack Price

Quantity

Product

SPECIAL OFFER

| Item Code

4-Pack discount

0361

10 x 5ml ampoules E l

$59.95

GH3 Pro (Generic Gerovital-H3)

60 x 1 OOmg tablets

$19.95

Heavy Detox

45 capsules

$48.95

Human G r o w t h Hormone (Saizen Injectable)

1 x 4 IU 1,33mg ampoule E l *

$54.95

10%

0268

Hydergine (Novartis)

40ml 40mg liquid bottle E l

$12.95

10%

0031

Hydergine (Novartis)

30 x 4.5mg tablets E ]

$22.95

10%

0032

Idebenone

60 x 30mg capsules #

$25.95

10%

0347

lmmuni-T3

60 capsules

$62.95

Inderal (Propranolol)

30 x 40mg tablets E l

$9.95

10%

L-Tryptophan

50 x 500mg capsules E l

$29.95

10%

0204

Laetrile

100 x 1 OOmg tablets E l *

$29.95

10%

0174

Laetrile

10 x 3g ampoules E l

$99.95

10%

0173

Laetrile (Vitamin B17/ Vita-B 17)

15ml bottle cream E K «

$39.95

10%

0253

Longevity Maca

180 x 500mg capsules

$24.95

Manerix (Moclamine)

30 x 150mg tablets E l

$24.95

Melatonin (PraevoSkin)

100ml cream bottle #

$39.95

Melatonin (Tl-Melatonin)

60 x 3mg tablets #

$14.95

Memantine (Ebixa)

50ml 5OOmg liquid bottle E l

$179.95

Memantine (Ebixa)

50 x 1 Omg tablets E ]

$159.95

Metformin (Metforal)

50 x 500mg tablets E ]

$15.95

10%

0042

Milnacipran (Ixel)

56 x 25mg capsules E l

$49.95

10%

0294

Gerovital-H3 (Injectable)

0360

10%

0357

0358 0034

0359 0039

10%

0304 0209

10%

0320 0260

0259

MinSaw-A (Topical)

1 25ml liquid bottle #

$39.95

Modafinil (Modiodal / Provigil)

30 x lOOmg tablets E l *

$149.95

NeyDent

50ml cream tube

$9.95

10%

01 18

NeyGeront

40 x 0.5ml capsules

$49.95

10%

0321

NeyGeront (Injectable)

5 x 2ml ampoules E l

$99.95

10%

0075

Nicergoline (Sermion)

45 x 5mg capsules E l

$19.95

10%

0161

Nizoral (Ketoconazole)

120ml 2 % shampoo bottle

$24.95

10%

Norvasc (Amlodipine)

28 x 5mg tablets E l

$29.95

(Toothpaste)

0044

0049 0333

Paxil (Seroxat)

14 x 20mg tablets E ]

$34.95

10%

0232

Penicillin-VK

30 x 250mg sachets E l

$19.95

10%

0206

Phenytoin (Epanutin / Dilantin)

28 x 25mg capsules E l

$9.95

10%

0299

Phenytoin (Epanutin / Dilantin)

100 x 1 OOmg capsules E l

$14.95

10%

0024

Picamilone

60 x 50mg tablets #

$29.95

10%

0184

Piracetam liquid (Nootropil)

100ml 20g bottle E l

$16.95

10%

0050

Piracetam (Nootropil)

60 x 800mg tablets E l

$21.95

10%

0205

Piracetam (Nootropil)

40 x 12OOmg tablets E l

$25.95

10%

0051

Poly-MVA

4oz. liquid bottle

$129.95

Pregnenolone (Micronized)

90 x 25mg capsules E l

$12.95

10%

Pregnenolone (Micronized)

50 x 1 OOmg capsules E l

$19.95

10%

0335

Progesterone Natural (Transmist)

1 oz spray bottle E l

$24.95

10%

0203

Proscar (Finasteride)

15 x 5mg tablets E ]

$39.95

10%

0067

Prozac (Fluoxetine)

14 x 20mg capsules E l

$24.95

10%

0238

Pyritinol (Cerbon)

60 x 1 OOmg tablets E ]

$19.95

10%

0167

Reboxetine (Davedax/ Edronax)

60 x 4mg tablets E l

$69.95

10%

0318

Resveratrol (Cell-Stat)

60 x 5mg capsules

$22.95

10%

0158

Retin-A Cream (Retin A)

20g 0.050% tube E l

$29.95

10%

0295

Retin-A Cream (Retirides)

30g 0.100% tube E l

$29.95

10%

0074

Rulid (Roxithromycine)

1 2 x 1 5 0 m g tablets E l

$39.95

10%

0077

SAMe (Samyr)

20 x 400mg tablets #

$39.95

10%

0231

SAMe (Injectable / Samyr)

5 x 400mg ampoules E l

$49.95

Silver Protein (Cream)

I oz. cream bottle

$29.95

El

0325

• 1• . ' •

• • • 10%

0334

•

0317 0274

Products marked with this symbol can not be shipped to the EU.

Products marked with this symbol are restricted in certain countries. Please see website for full details. # M X O R D E R I N G + 4 4 ( 0 ) 2 0 8 181 6 1 0 6

Products marked with this symbol can not be shipped to the UK. 33

IAS Product Order Guide - Page 3

1 SPECIAL OFFER

1 Item Code

Quantity

Pack Price

Silver Protein (Gel)

1 oz. gel bottle

$29.95

10%

0194

Product

4-Pack discount

Silver Protein (Mouth Spray)

1 oz. spray bottle

$39.95

10%

0177

Silver Protein (Nasal Spray)

1 oz. drops bottle

$34.95

10%

0322

Silver Protein (Oral)

4 oz. liquid bottle

$49.95

10%

0160

Sinemet

50 x lOOmg tablets [ 3

$39.95

10%

0081

Solaris (Sun Blocker)

150ml cream bottle

$49.95

Stablon (Tianeptine)

30 x I2.5mg tablets m

$34.95

10%

0372

Testosterone Prohormone (T-Boost)

30ml mouth spray 13 â&#x20AC;˘>

$24.95

10%

0252

Tetracycline (Ambramicina)

16 x 250mg tablets ( 3

$19.95

10%

0143

Thymus (Injectable/ Thym-Uvocal)

10 x 2ml ampoules [ 3

$99.95

Thymus (Oral/ Thym-Uvocal)

100 x 240mg capsules

$59.95

10%

Thyroid Natural (Half Grain)

100 x 30mg tablets [ 3

$29.95

10%

0324

Thyroid Natural (One Grain)

100 x 60mg tablets 13

$34.95

10%

0323

Thyroid T3 (Synthetic / Titre)

50 x 20mcg tablets [ 3

$24.95

10%

0314

0300

0326 0086

Thyroid T4 (Synthetic / Eutirox)

50 x 1 OOmcg tablets [ 3

$19.95

10%

0315

V I -Immunitor

30 x 250mg tablets #

$69.95

10%

0306

Viagra (Sildenafil)

4 x 1 OOmg tablets 13

$69.95

Vinpocetine (Intelectol)

50 x 5mg tablets #

$14.95

Xanthinol Nicotinate (Complamin)

50 x 150mg tablets #

$19.95

Yohimbine (Yocoral)

100 x 5mg tablets 13 *

$49.95

Zirtec (Zyrtec)

20 x lOmg tablets 13

$24.95

Zocor (Simvastatin)

10 x 40mg tablets [ 3

$29.95

0090 10%

0091

10%

0012

10%

0336

0227

0337

exclusive special offer If you buy a 3 month supply of Dr Garry Gordon's unique chelating multi vitamin Beyond Chelation Improved ($52.95 ea) we will give you a copy of the Anti Aging Medicine Reference (AAMR worth $69.95) absolutely free!

Beyond Chelation Improved (BCI)

BCI is so much more than a multi vitamin. BCI is a combination of the purest ingredients in the world and Dr Gordon's specially designed oral chelation agents. BCI should form the foundation of any ones program aiming to attain optimal health.

Anti Aging Medicine Reference

The AAMR is an invaluable guide to the drugs, hormones and nutrients used in anti-aging medicine today. Among other things the AAMR outlines the pharmacology, uses, doses, contraindications and clinical references, of a huge range of substances forming a vital resource for the anti-aging enthusiast or practitioner.

To take advantage of this special offer simply: Call our toll free number+1-866-800-4677 Visit our website: www.antiaging-systems.com Or if you wish to order by post check the promotional box on the order form on the opposite page.

Valid until the 31st May 2005

34

ONLINE

O R D E R I N G www.antiaging-magazine.com

|

Product Order Form Contact/ delivery details

please fill out in block capitals

Order methods To place an order by fax:

Cut out or copy the product order form and fax it to +44 208 181 6106

To place an order by phone:

Call one of the numbers below USA & Canada

1-866-800-4677

Rest of world +44 (0)207 117 0107 To place an order by post:

Cut out or copy the product order form and mail it together with a bank check or postal money order made payable to: International Antiaging Systems, Beckett House, 14 Billing Road, Northampton, NN1 5AW, Great Britain

Customer No. (if known)

To place an order online:

Simply visit: www.antiaging-magazine.com

Items required (please use the item codes from the A-Z listing) Product name

Item code

Quantity

Promotional offer box If you have ordered 3 BCI and wish to receive a free copy of the AntiAging Medicine reference please check the box provided.

For full details of this exclusive special offer see page 34

Payment details Type of card

Visa

Card No.

Signature & declaration

o I I

Declaration: I hereby declare that I am of legal age and I will abide by the IAS terms and conditions. I am under a physician's guidance and I will assume full liabilty and responsibility for the use and importation of my order. I hold the shipper and IAS Ltd., harmless from any legal action resulting from the purchase, use or importation of these products.

FAX

O R D E R I N G +44 (0)208 181 6106

Signature Date 35

Healthy bathing with Beyond Clean Research has proven that reduced Levels of iron in the skin can dramatically reduce skin aging. Iron reacts with UV to generate massive amounts of free radicals, no surprise then that sun exposure is responsible for up to 90% of skin aging.

Now with Beyond Clean, you can help prevent the absorption of toxic metals which are found in most water supplies by simply adding Beyond Clean into your bathtub. Beyond Clean binds to the metals in the water and also in the skin, providing a level of both protection (inhibiting absorption) and detoxifying.

Further studies have indicated that a hot lO-minute shower is equivalent to absorb' ing metals and other chemicals as drinking 8 glasses of the same water!

" W e arc all careful about what w e drink. Now it's time to be careful about what we bath in. The skin is our largest organ, and it also needs to be taken care of"

Dr. Garry Gordon MD President Gordon Research Institute

www.antiaging--magazine.com