Aging Matters Magazine: V3 ISSUE 40 2022, 'Cleaning up with autophagy' by International Antiaging Systems (IAS)

V3 ISSUE 40 2022

The IAS private members club magazine

CLEANING UP with autophagy

In this issue: Dr. Marios Kyriazis describes cell cleaning Living longer and stronger Removing heavy metals Recommended videos

Testimonials

Contents

Suzanne Somers “The Aging Matters™ magazine is spectacular, very readable and chock full of the latest and greatest. It’s the magazine I wait for and anticipate.”

Thierry Hertoghe, M.D. “IAS have a history of making throughout the world crucial, but difficult to access medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has helped this new medical speciality move forward.”

Jonathan V. Wright M.D. “Every adult has the right to take care of his or her own personal health as he or she chooses. In the 21st century this universal human right has been nearly obliterated by an ocean of nanny state regulations and deliberate suppression of information by bureaucracies, with hidden and not-so hidden agendas. International Antiaging Systems is a beacon of useful health care information and a literal island of freedom of health care product choice in our otherwise unfree health care world.”

Frank Shallenberger M.D. “The tools that are available today to treat the aging process are truly amazing. Thanks to IAS the field of antiaging medicine has expanded to the point that feeling and functioning 10-20 years younger is easily achievable. Their information and product services are regularly used by my patients.”

Walter Pierpaoli, M.D. “I have known IAS for many years’ and they are a qualified group who provide for me, my family and my patients. Their skill and professional capacity have liberated me from all sorts of problems concerning the search for guaranteed and often rare supplements, or anything which is available but problematic to find. Their service goes far beyond duty and helps in many ways to maintain optimal health.”

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Aubrey de Grey PH.D “IAS has shown great vision and leadership as an organization focused mainly on the provision of contemporary medical interventions against aging, and in also supporting the SENS Foundation efforts to hasten the development of much more powerful future interventions.”

Nicholas Perricone M.D. “IAS is an outstanding resource for the finest, most up-todate news and information on healthy aging. They also offer products of the highest integrity and efficacy. In fact, IAS is the world’s greatest source, (often the only source) for the most cutting-edge and advanced nutrients to ensure optimum health span and maximum life span.”

Welcome

Testimonials Professionals’ comment on IAS

Welcome To the first edition of 2022

Forefront Recent stories in the news

Cleaning up with autophagy Marios Kyriazis, M.D. explains this process

Living longer and living stronger Have you ever considered what’s at stake? Reducing toxic heavy metals The art of chelation

Spotlights A few details about special products

Media Page Some recommended videos

Antiaging-Systems.com Where to find what you need

www.aging-matters.com Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members (and therefore is not intended for the public). It focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental, and internal changes consisting of the diseases and disorders such as cancer, arthritis, and senile dementias etc. However, the focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual. Copyright 2022: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork, or advertising materials while in transmission or with the publisher or their agents. Disclaimer: All educational information is offered strictly under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS, nor the magazine. Terms and conditions are subject to change without notice.

For more information visit: Your comments are welcome at: editor@aging-matters.com

As I typed out the number ‘40’ for this cover, (because this is the 40th issue of the Aging Matters™ magazine), I said to myself; “well that’s another 10 years!” Yet that wasn’t even the starting point of the IAS private members club information; I still recall our first newsletter, the ‘Antiaging Bulletin’ - it was released in 1996, just after our first visit to the American Academy of Antiaging Medicine (A4M) at the end of 1995. In those early days it was black and white, but a little later it morphed into a booklet, and we introduced a third color, (it was yellow!) But then, in the summer of 2004 we finally updated it into a full-color magazine, one entitled the ‘Antiaging Magazine.’ It was a big update, so it became version 2. Then version 3, (with an all-new and fresh design), was renamed the ‘Aging Matters™’ magazine in 2012. And don’t forget that whenever you want to, you can download any of the earlier V3 and even some of the V2 publications; there are 50 to choose from online. In this issue we cover the hot topic of autophagy. Essentially, this is the process that our cells use to clean themselves. Here, Dr. Marios Kyriazis goes into the process and how we can support and nurture it. After all, we all know that a clean home is a healthy home, and nowhere is that truer than in our own bodies. In the previous issue (number 39), Dr. Ward Dean was interviewed by Richard Swift about the use of nootropics, (the so-called smart drugs) for society at large. Now, Richard follows it up with a thoughtful piece, it is if you will, an attempt to consider our needs and approach to health as we get older. And finally, Will Block delves into the issues of heavy metals and what can be done about them. It’s strange to consider that we are all exposed to varying levels of mercury, lead, and cadmium etc., even if we are working in an office in New York or London etc. I guess the message is- stay cleaner and healthier, thereby improving your odds of a long and strong life. Remember, we always welcome any constructive comments or suggestions. Please use the email shown on this page.

Phil Micans, MS, PharmB Editor, Aging Matters™ Magazine Ward Dean, M.D. Medical Director, IAS Group Aging Matters | 3 |

Forefront

EXERCISE MAY LOWER ALZHEIMER’S RISK BY REDUCING INFLAMMATION IN THE BRAIN “Please remember the real me when I cannot remember you.” The number of people living with Alzheimer’s disease, a type of dementia, doubles every five years beyond age 65. Sadly, it’s a progressive and fatal disease, however, much like in most of our articles – we have gone searching for new developments and hope. Alzeimer’s disease changes a person and takes away their cherished memories whilst loved ones can only watch and care for them. In a recent study led by researchers at the University of California San Francisco (UCSF), it was discovered that physical activity may reduce the risk of Alzheimer’s disease. Whilst their findings can’t slow the progression of or cure the disease, experts are getting a much better understanding and who knows what the future holds. Alzheimer’s disease is a type of brain disease, the most common form of dementia making up for 60-80% of cases. The disease is believed to begin around 20 years | 4 | Aging Matters

before symptoms start to show, they occur because nerve cells (neurons) in parts of the brain that are involved in thinking, learning and memory (cognitive function) have been damaged or destroyed. Eventually, neurons in parts of the brain that enable a person to carry out basic bodily functions such as walking, and swallowing are affected. In a lot of cases, individuals become bed-bound and

require around the clock care. Alzheimer’s disease is the 6th leading cause of death of the 65+. A decline in certain cognitive abilities such as memory and attention is typical with ageing, when taking medication or as a result of other conditions. Tests can be done to ascertain if a decline in cognitive function is simply due to ageing or related to brain disease.

What are the most common symptoms of Alzheimer’s disease? ► Memory loss that disrupts daily life ► Challenges in planning or solving problems ► Difficulty completing familiar tasks ► Confusion with time and place ► Trouble understanding visual images ► New problems with words – speaking or writing ► Misplacing things or an inability to retrace steps ► Decreased or poor judgement ► Withdrawal from work or social activities ► Changes in mood or personality

What we discovered… In the study led by the UCSF, the researchers found that physical exercise had associations with reduced activation of microglia, the primary immune cells in the brain. It’s a significant discovery because currently there is no cure for dementia or a way to slow down the progression of Alzheimer’s. The study’s co-author, Dr Kaitlin Casaletto, a professor at UCSF, told Medical News Today, “Many studies show that physical activity relates to better brain and cognitive health (e.g., estimates indicate that inactivity alone accounts for 13% of Alzheimer’s disease cases worldwide). Yet, we still do not fundamentally understand the mechanisms linking physical activity to cognition in humans. Our study is the first human data showing that microglial activation (“brain inflammation”) may be a meaningful mechanism.” The study appears in the Journal of Neuroscience. Too much of a good thing can be detrimental… The nervous system is made up of two types of cells, neurons and glial cells. Glial cells protect the neurons that are responsible for sending electrical and chemical signals to the brain. Microglial are subtypes of glial cells, they are the brain’s immune cells that become activated in response to an infection or neuro damage.

They act as a security system, cleaning up dead cells and debris and killing off invading bacteria. That’s a good thing right? Yes, until there are too many microglial cells. The problem is when the production of microglia is elevated it can cause inflammation of the brain and promote cell death, leading to a reduction in cognition in humans – potentially resulting in Alzheimer’s disease. Scientists know that physical exercise in animals reduces the activation of microglia and other brain markers of inflammation. The study investigated the relationship between physical activity and microglial activation in older adults. Given the association between physical activity and improvements in cognitive function and synaptic health, the study estimated the extent to which changes in microglial activity may support these effects of physical activity. Researchers found that, as in animals, physical activity had associations with reduced microglial activation in older adults. Moreover, the study’s results suggest that reduced microglial activation could be one of the brain pathways through which physical activity protects individuals from cognitive decline, especially in Alzheimer’s disease. The connection between brain health and Alzheimer’s disease is something that has left experts

such as neurologists, neuropsychologists and geriatric psychiatrists frustrated in their mission to find hope for patients and carers. The burden and strain put upon family or carers dealing with a person with Alzheimer’s can be overwhelming but there is help out there. There are support groups and options for respite for those people who are caring for loved ones in their homes. Find a support group near you Are you concerned about your brain health? Is your memory not as good as it used to be? Looking after your brain doesn’t have to be hard work, check out these 40 simple brain health tips. ► Simple steps to better brain health ► Self-assessment dementia test Products worth a mention: Aniracetam, NMN or Cerluten for better brain health. Centrophenoxine (CentroPro™) Boost your memory and mental performance with CentroPro(tm). It contains centrophenoxine, which can help you think clearer and remember more by aiding your brain’s infrastructure. Centrophenoxine has been Aging Matters | 5 |

Forefront found to improve cognitive function by raising the levels of the neurotransmitter Acetylcholine, and reduce the age-related accumulation of the toxin lipofuscin. This is found in various tissues including those within the brain. NMN (beta Nicotinamide Mononucleotide) Your NAD+ levels have direct links to the ageing process – As we age, our NAD+ levels decline naturally, regardless of your state of health. Research shows that supplementation with NMN can support the function of sirtuins, the genes that are related to healthy ageing. NAD+ is a master regulator of metabolism and replete NAD+ levels are linked with better overall health. Research suggests that NMN

may support mitochondrial function and can interfere with an age-dependent energy production decline. CNS peptide (Cerluten®) 60 Pack Cerluten regulates the metabolism processes in the brain cells and restoration of the central nervous system function. It helps patients with brain injuries and diseases such as chronic fatigue syndrome, multiple sclerosis, depression, Parkinson’s and Alzheimer’s. Helps patients suffering from stress, memory loss or recovering from strokes. References: For more information scan this QR code

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www.antiaging-systems.com

POLLUTION AND THE IMPACT ON AGING As we age, our bodies are less likely to be able to cope with environmental hazards, as our environment becomes more polluted, the effects on the body will speed up, impacting our ageing process. Exposure to pollution increases freeradical damage which speeds up ageing and damages DNA and tissue in our body. Pollution and climate change isn’t a future problem anymore, it’s a now problem and we’re not getting any younger. Pollution isn’t just an environmental issue. The recent UN Climate Change Conference (COP 26) attended by world leaders in Glasgow reminded us that climate change is one of the world’s most pressing problems, a code red for humanity according to some experts. Recent studies revealed that some scientists believe it has been the hottest decade ever. Heat and sunshine have cooked the air along with lingering harmful chemicals creating a smog of gas around us. Pollution isn’t just an environmental issue, it can have a major impact on the body. Harmful products can enter the body through inhalation such as breathing in carbon oxide from car emissions or chemical coated

particles that come in contact with the skin. According to a comprehensive new global review, pollution can trigger an inflammatory response damaging every organ and every cell in the human body. The research shows headto-toe harm, from heart and lung disease to diabetes and dementia, and from liver problems and bladder cancer to brittle bones and damaged skin. Pollution and the skin. Pollution breaks down collagen and oxidizes the lipid layer in the skin and that impairs the skin barrier function. Our skin is a living layer all over our body that, with our skeleton, holds us together and pollution

can make our skin weak. Smog particles are generally too large to penetrate the skin, but they can disturb the barrier, resulting in dehydration, sensitivity, uneven skin tone, dullness, acne and premature ageing. German physician Dr Barbara Sturm revealed that dozens of studies show that airborne pollutants on human skin can contribute to skin cancer. Pollution and the immune system. Inhaling dirty air can trigger the release of white blood cells into the bloodstream and can result in inflammation and damage. Polluted particulate matter triggers an imbalance in the immune system and molecules in cells begin to react when they are exposed to the particulate matter reducing the efficiency of the immune system.

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Forefront The effects of airborne pollutants on the immune system have been most widely studied in the respiratory tract. Entry may occur as a volatile gas such as ozone or benzene. Or as liquid droplets such as sulfuric acid or nitrogen dioxide. Indoor pollution HO (World Health Organization) reported that approximately 4 million people die prematurely attributed to household air pollution every year. A large majority of people spend 90% of their time indoors surrounded by pollutants such as dust, dirt, gases, mould, smoke, cleaning products or building materials. ?

►G et outside for some fresh air but avoid built-up areas with busy roads ►H ave good ventilation inside your home especially when you are cleaning or decorating ►H ave your chimney swept every year because burning things on fire such as wood or coal can produce high levels of pollution

► Don’t vape indoors ► Wash your hands regularly to remove any harmful chemicals that may have got on your skin ► Ventilate your home when decorating, chemicals from paint or white spirit for example can be harmful

► Wear goggles to prevent air pollution from entering your eyes ► Don’t stand near idle engines or too close to machinery

► Be observant and look for potential hazards

►O pt for electric cooking and heating

► Use chemical-free cleaning products

►U se a carbon monoxide alarm

► Remove asbestos and fibreglass found within the home

How much we are affected by pollution individually depends on different factors like where you live, physical and mental health, age, lifestyle and standard of living but we should all have the same goal

►W ear rubber gloves when using products containing chemicals ►D on’t smoke indoors, there are many reasons to give up smoking for your own health and for those around you

► Don’t work too close to machinery ► Check radon levels ► Look at the volatile organic compound levels in items in the home

References:

► Walk on the other side of the road near building sites or renovations

► Minimise the use of candles and incense sticks

►T reat dampness and mould found around the home

– to protect our planet. The threats that climate change poses to the human race are real but with a global effort, we could avoid a potential environmental disaster.

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AUTOPHAGY - KEEPING THE CELLS CLEAN

AUTOPHAGY – KEEPING THE CELLS CLEAN

In any case, autophagy is a complex event involving three types of processes (Fig 1): Macroautophagy About the author

By Marios Kyriazis, M.D.

If you mention the world ‘autophagy’ to any Greekspeaking person, they will probably shudder, and their hair will stand on end. Autophagy means ‘selfeating,’ or ‘consuming your own self’, in other words eating your own flesh. In biology however, autophagy, (while still meaning ‘selfeating’) is a protein turnover pathway, a catalytic process, which aims to degrade and recycle cellular components.

This process maintains cellular function during (or after) stress, when damaged material accumulates, and it must be eliminated. Without the process of autophagy, there would be an accumulation of defective macromolecules and other cell junk/ material, which would certainly lead to dysfunction, neurodegeneration, or even cancer.

Dr. Marios Kyriazis qualified as an MD from the University of Rome, Italy, and has worked as a clinician in acute medicine for 40 years in Cyprus, the USA and the UK. He is qualified Gerontologist with interest in the biology of aging and a member of the ‘Royal Society of Biology.’ He also has a post-graduate qualification in geriatric medicine from the ‘Royal College of Physicians,’ and an affiliated researcher with the University of Brussels on matters related to longevity.

The effectiveness of this essential autophagic process diminishes with age, and results in the accumulation of damaged material inside the cell, eventually leading to clinical dysfunction. At the same time, it has been shown that maintaining the autophagic process in good working order, reduces the risk of such dysfunction and helps improve longevity (1).

autophagy Lysosome

Membrane

Autolysosome Autophagosome

Mitichondria 1. Forms a double membrane

2. The autophagosome formation

3. Autophagosome fuses wih a lysosome

4. Degradation and recycling of cellular component

Figure 1: Macro, Micro, and Chaperone-Mediated Autophagy, in the specific case of Parkinson’s Disease. Source: Molecular Brain, Biomed Central, September 2009. Author: Cheung and Ip. (Permission: This picture is part of a paper distributed under CC-by 2.0).

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This process marks and prepares any damaged molecules, delivers them to the lysosomes for degradation and for subsequent release of the degraded material back into the cell environment.

is transported inside the lysosomes via chaperone proteins. One such chaperone is the HSC70 (heat shock protein 70 complex), which is involved in stress (2). This shows the direct relationship that exists between autophagy and stress.

Remember that the lysosomes are small organs within the cell, surrounded by their own membrane, and responsible for degrading and recycling cellular waste (Fig 2).

LYSOSOME Membrane Enzymes

Microautophagy: This is where the lysosome itself picks up any circulating damaged material directly and degrades it.

Transport proteins

Chaperone-mediated autophagy (CMA) Here, as the term suggests, the damaged material

Figure 2: The components of the lysosome.

HOW TO ACTIVATE AUTOPHAGY Intermittent fasting and calorie restriction are two known ways of activating autophagy through a variety of physiological mechanisms. One such mechanism involves the mammalian target of rapamycin complex 1 (mTORC1), commonly known as the TOR pathway, which regulates the input of signals depending on nutrient availability, and integrates the function of growth factors, stress response, and cell growth. As a result, TOR controls the rate of cell aging. Therefore,

regulation of autophagy affects the rate of aging not only aging of cells, but also aging of the entire organism (3). I have already mentioned that impaired autophagy, as seen during the aging process, alters homeostasis and results in dysfunction. Rapamycin (with regulates TOR) plays an intricate role in autophagy, and we can see an example of this role in BOX 1.

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AUTOPHAGY - KEEPING THE CELLS CLEAN

BOX 1 An example of the relationship between TOR, rapamycin, autophagy, and aging: ► In the brain, there is an association between autophagy and a decline in neuronal function.

► Rapamycin acting through the above mechanism was found to improve the sense of olphaction in mice, while human trials are still in progress. Therefore, rapamycin, through regulation of neuro-autophagy, improves clinical function (4).

► Rapamycin was found to regulate autophagy in the brain and so it improves the function of neural cells, such as the neural progenitor cells. These are cells which may develop into fully functional brain cells. Autophagy vs Apoptosis Some people confuse the process of autophagy with that of apoptosis. What is the difference between the two? Apoptosis is the programmed death of entire cells, whereas autophagy involves molecules and other components of the cell. Putting it simply, autophagy is the cleaner inside the cells and apoptosis is the cleaner of the entire cells. Having said that, it is worth mentioning here that autophagy is not only

involved in degradation of molecules and components of cells, but it can (at least some mechanisms of it) also play a part in regulating the death of the entire cell. This is called ‘autophagy-dependent cell death’ (ADCD) and the mechanisms involved in this are generally different from those involved in apoptosis. But the fact remains that the cleaning of material inside the cell, and the death of the entire cell are interrelated(5). In any case, here we see a flaw in the thinking of those who blindly aim to diminish apoptosis (hoping to save the

Neuron anatomy

cell), without considering that the cell may also die via other mechanisms. I must clarify that autophagy, like so many other processes, is not a ‘black or white’ matter. In other words, it is not ‘good’ to have it, and ‘bad’ not to have it. Instead, it is a matter of regulation and modulation because there are many precision mechanisms which need to be structured and executed in a stepwise manner. Matters such as the precision of interaction of autophagy receptors, the nature of the target that

APOPTOSIS

Normal Cell

Initiation of Apoptosis

Membrane Blebbing

Figure 3: Stages of apoptosis from normal cell to final stage of formation of membrane blebbingapoptosis from normal cell to final stage of formation of membrane blebbing

Apoptosis

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needs to be eliminated, the intricate orchestration of specialized autophagy signals, the integration of all processes, all of these and many more actions need to be regulated and may lead to a different result if their regulation is defective. Therefore, it is better to talk about ‘modulation’ rather than a clear-cut positive or negative action. In simple terms, modulation means to reduce what is high, and increase what is low, to reach an ideal balance. Apart from rapamycin, mentioned above, let’s briefly review two specific examples of compounds which play a leading role in autophagy. These are fisetin and quercetin. Another example, that of spermidine, will be discussed in some more detail separately below. 1. Fisetin It is progressively accepted that bioactive natural compounds can modulate many signaling pathways. In the case of cancer, these signaling pathways become deregulated, but research shows that it is possible to use these bioactive compounds to normalize overall action. One such natural bioactive agent is fisetin (6). Fisetin is a strong natural flavonoid found on fruits like strawberries, grapes and kiwis and it has a wide variety of actions, particularly in autophagy and thus, in aging. Fisetin regulates autophagy in cancer, as well as in other chronic age-related

degenerative conditions such as osteoarthritis and inflammation. In the above study (6), the authors state that: “These developments will surely pave the way for full-fledge and welldesigned clinical trials of fisetin in different cancers. However, we still must comprehensively analyze and fully unlock pharmacological potential of fisetin against different oncogenic signaling cascades and noncoding RNAs. Fisetin has remarkable potential as chemopreventive agent and future studies must converge on the identification of additional regulatory roles of fisetin for inhibition and prevention of cancers”. In addition, through an effect on autophagy, fisetin may diminish inflammation, and the mechanisms of this action have been explained in recent studies (7). Fisetin is found in several foods, but it is also available as a nutritional supplement in oral form. 2. Quercetin We know that polyphenols are naturally occurring bioactive compounds with a wide health-boosting action. Polyphenols include some wellknown agents such as curcumin, resveratrol, hesperidin, catechin

and quercetin. Most such compounds have neuroprotective, anticancer and antidiabetic effects, through modulation of autophagy (8). Concentrating specifically on quercetin, found in foods like capers, kale and onions, we find that this has remarkable effects on regulating autophagy (9). One study stated: “Quercetin induced extensive autophagy and subsequent death in cancer cells mediated by the inhibition of proteasomal activity and mTOR signaling” (10). At low concentrations, quercetin blocks proliferation of cancer cells, and induces protective autophagy. In addition, it can increase apoptosis in these cells. Apart from the above two agents, there are several other natural compounds which can activate autophagy (11) (see BOX 2).

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AUTOPHAGY - KEEPING THE CELLS CLEAN

BOX 2 Some brief and current examples of autophagy regulators are highlighted. The description is brief, with the aim of stimulating you to study these in your own time. ►R esveratrol from red wine has been recently studied for its beneficial effect in reducing Sars-CoV-2 infection through autophagy (12).

Spermidine Now, we can discuss an up-and-coming compound which has multiple effects in aging in general, and especially autophagy. Spermidine is a very promising compound with actions that are only now being evaluated in detail. It is a natural polyamine compound with effects on heart disease, brain

AUTOPHAGY - KEEPING THE CELLS CLEAN

►U rolithin A is found in pomegranates and walnuts, and it has promising effects on mitochondrial autophagy. In other words, enhances the elimination of damaged mitochondria, thus improves muscle function (13). ► Trehalose is a sugar in fungi, and was found in a very recent study to alleviate age-related brain dysfunction, and it is characterized as an ‘inducer of mTORindependent autophagy’ (14). ► Lithium has multiple effects on age-related degeneration, but it is sufficient to mention that one of these effects is its capacity to regulate autophagy in the bone tissue and thus improve new bone formation (15).

degeneration, cancer, and inflammation, among others (16) . Spermidine also extends lifespan and healthspan. Although the levels of spermidine fall with age, an increased nutritional intake of it has been associated with reduced mortality from cancer and heart disease (17). Several Calorie Restriction Mimetics (CRM) have autophagic actions. To remind you, CRM are drugs, supplements or compounds which mimic the physiological actions of Calorie Restriction (CR), so in fact we may get the benefits of CR without having to go through the restricted diet!

CRM have one action in common: they regulate autophagy. Some of these CRM are well known to many people, for example: glucosamine, NAD, resveratrol, curcumin, EGCG, quercetin etc. And, of course, spermidine. Spermidine (found in nutrients such as wheat germ, nuts, cheese, soya and in some fermented foods, and in oral supplement

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Aging Matters | 15 |

AUTOPHAGY - KEEPING THE CELLS CLEAN

form) prevents senescence of stem cells, modulates inflammation, protects mitochondria during aging and has some beneficial effects on cognition. Importantly, it also has effects on autophagy, and more specifically, macroautophagy. Apart from dietary sources, spermidine is also produced by the gut microbiome and through biosynthesis inside the cell (18). One very interesting fact related to spermidine is that it interferes with autophagy in the germline. This means that our sperm cells (in men) and the ova (in women) are under the (positive or negative) influence of spermidine. This is one part of the story. The other part is that spermidine also modulates the function of neurons (improves autophagy, oxygen consumption and regulates apoptosis in neurons) (19). This dual action of spermidine is very relevant when we consider a

hypothesis I proposed a few years ago, the Indispensable Soma Hypothesis (www. indispensablesoma.info). I proposed that there is a direct competition for survival between neurons (cognition) and the germline (procreation) (20), where neurons try to survive and function well by ‘stealing’ repair resources from the germline. This means that a healthy neuron may live longer (and therefore we too live longer), when at the same time, the germ cells become defective, and this results in a reduced procreation. Life continues not through more children being born, but through us living longer. In any case, it would be interesting to explore the function of spermidine at a deeper level. Spermidine (as the name may suggest) was originally found in sperm. We may ask ourselves: why does a chemical in semen benefit the neurons? The answer could be that it may underline the close relationship that exists in the race for

AUTOPHAGY - KEEPING THE CELLS CLEAN

resources between the neuron’s vs the germline, just like my hypothesis suggests. It would be very simplistic to say that spermidine causes improvements that maintain the neuron or cause damage that downregulates the germline. What is more relevant is to say that spermidine is a ‘go-between’ of the complex relationship that exists between neurons and the germline. There is a balance between the two, and my hypothesis is about altering this balance in favor of the neuron. Incidentally, one way that may help in this respect is to expose ourselves to meaningful information that requires us to act constructively, in other words, maintain our brain in a state of ‘positive stress’. This diverts repair resources from the germline to the neuron, and spermidine is the agent in the middle, which regulates this process (Fig3).

NEURON

IRE1, PERK, ATF4

Apoptosis Hormetic Information

GERM CELL

Figure 3: Exposing our brain to ‘positive stress’ (hormetic information) activates the neuronal stress response which, through a variety of mechanisms - some of which are modulated by spermidine, diminishes the function of the germline, and augments the function of the neurons. www.eurekalert.org/news-releases/517306.

With that in mind, we know that spermidine protects female germline stem cells through, among other mechanisms, autophagy (21). On the other hand, as already mentioned, spermidine also improves autophagy in the neuron, and there are studies linking consumption of spermidine with a reduced risk of cognitive impairment in humans (22). It is very relevant to realize that the concentration of spermidine (apart from its high concentration in the sperm) is also high in the human brain. This must be because it has important actions to perform there, and these include regulation of the opioid pathways, neuronal signaling, and control of brain inflammation, among others (23). In a recent multicenter double-blind study of spermidine supplementation in patients with dementia (24), it was shown that:

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Stress response

“…Memory tests were carried out on 85 subjects aged between 60 and 96 years in 6 nursing homes. The results demonstrated a clear correlation between the intake of spermidine and the improvement in cognitive performance in subjects with mild and moderate dementia in the group

treated with the higher spermidine dosage. The most substantial improvement in test performance was found in the group of subjects with mild dementia with an increase of 2.23 points (p = 0.026) in the mini mental state examination (MMSE) and 1.99 (p = 0.47) Aging Matters | 17 |

AUTOPHAGY - KEEPING THE CELLS CLEAN

in phonematic fluidity. By comparison, the group which had a lower spermidine intake showed consistent or declining cognitive performance.”

A War of Hormetic Tradeoffs. Curr Aging Sci, 2017;10(4):242-245 21. Yuan X et al. Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression. Cell Biosci 2021;11(1):107 22. Schroeder S et al. Dietary spermidine

Conclusion There are some main messages that we can gain from the above discussion. The first, is that autophagy is a very important process during aging, and this may be modified through dietary and nutritional measures. The second is that some of these measures may carry more importance than others, and spermidine is a good example. By considering the example of spermidine in autophagy, we also can study the relationship that exists between the neurons

25. Kyriazis M. Reversal of informational entropy and the acquisition of germlike immortality by somatic cells. Curr Aging Sci, 2014;7(1):9-16

24. Pekar T et al. The positive effect of spermidine in older adults suffering

Rapamycin is the mTOR inhibitor and the germ cells. If we manipulate this relationship wisely, we may be able to increase our lifespan (25). This is only a short presentation of autophagy. It would be an ideal opportunity for you to further explore this in your

1. Barbosa MC et al. Hallmarks of Aging: An Autophagic Perspective. Frontiers in Endocrinology, 2019 (9) 790 2. U et al. The Hsp70 chaperone is a major player in stress-induced transposable element activation. Proceedings of the National Academy of Sciences, 2019, 116 (36) 17943-17950; DOI: 10.1073/pnas.1903936116

8. Brimson JM et al. Plant Polyphenols for Aging Health: Implication from Their Autophagy Modulating Properties in Age-Associated Diseases. Pharmaceuticals (Basel), 2021 Sep 27;14(10):982. doi: 10.3390/ph14100982

3. Markaki M, Tavernarakis N: Metabolic Control by Target of Rapamycin and Autophagy during Ageing - A Mini-Review. Gerontology, 2013;59:340348. doi: 10.1159/000348599

9. Ikari S et al. Quercetin in Tartary Buckwheat Induces Autophagy against Protein Aggregations Antioxidants (Basel), 2021 Jul 29;10(8):1217. doi: 10.3390/antiox10081217

4. Yang N et al. Activation of Autophagy Ameliorates Age-Related Neurogenesis Decline and Neurodysfunction in Adult Mice. Stem Cell Rev Rep, 2021. doi: 10.1007/s12015-021-10265-0. Epub ahead of print. PMID: 34546510

10. Hasima N, Ozpolat B. Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. Cell Death Dis 5, e1509, 2014. https://doi.org/10.1038/ cddis.2014.467

5. Tsujimoto Y, Shimizu S. Another way to die: autophagic programmed cell death. Cell Death Differ, 2005, 12, 1528–1534. https://doi.org/10.1038/ sj.cdd.4401777

11. Stephen D, Raj SD et al. Natural products as geroprotectors: An autophagy perspective Med Res Rev. 2021 May 10. doi: 10.1002/med.21815. Online ahead of print

6. Farooqi A et al. Cancer chemopreventive role of fisetin: Regulation of cell signaling pathways in different cancers. Pharmacol Res, 2021;172:105784. doi: 10.1016/j. phrs.2021.105784

12. Vidoni C et al. Targeting autophagy with natural products to prevent SARS-CoV-2 infection. J Tradit Complement Med, 2021 Oct 14. doi: 10.1016/j.jtcme.2021.10.003. Epub ahead of print

| 18 | Aging Matters

23. Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M. Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders. Neuropeptides, 2020;83:102083

from dementia: First results of a 3-month trial. Wien Klin Wochenschr, 2021 May;133(9-10):484-491

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7. Sun Y et al. Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells. Food Nutr Res, 2021;65. doi: 10.29219/fnr. v65.6355. eCollection 2021

References:

improves cognitive function. Cell Rep 2021;35(2):108985. doi: 10.1016/j. celrep.2021.108985

own time, but always under the guidance of a competent health professional. This exploration may also help in maintaining your brain under a state of ‘positive stress’, which is a step towards increasing healthy longevity!

Originally discovered in the soils of Easter Island, rapamycin has become the Di-rigor mTOR inhibitor, (since it stands for Mammalian Target Of Rapamycin). This process and its resultant activation of autophagy is gaining much interest in the antiaging field.

13. Luan P et al. Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy. Sci Transl Med, 2021;13(588): eabb0319 14. Korolenko TA et al. Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice. Cells, 2021;10(10):2557 15. Huang et al. Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy. Bioact Mater 2021;6(10):3074-3084

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16. Madeo et al. Spermidine in health and disease. Science, 2018 Jan 26;359(6374): eaan2788 17. Madeo F et al. Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy, 2019 Jan;15(1):165-168 18. Hofer SJ et al. Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging. Autophagy, 2021 Jun 9:1-3. doi: 10.1080/15548627.2021.1933299 19. Jing YH et al. Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro. Experimental Gerontology, 2018 (108) 77-86 20. Kyriazis M. Neurons vs. Germline:

For further information see:

www.antiaging-systems.com Note: US$ prices are subject to shipping and handling (and additional taxes where appropriate). Disclaimer: All educational information is provided under the IAS terms and conditions (which may change without notice) and does not replace the advice of your physician. Restrictions may apply in some countries.

Aging Matters | 19 |

LIVING LONG & STRONG - CHALLENGING THE CONSUMER MINDSET

By Richard Swift Today we examine and challenge some of the assumptions we are all persuaded to accept. My aim in writing this article is to help you make wise and balanced judgements about the direction you want your health and longevity to take. An interesting way to read this article This section is about Judging like Judges Judge, and we can all do it. See yourself chairing a committee whose task is to decide the future course of your life. The members of your committee are the inner- feelings that effectively decide what the overall ‘You’ decides and does. The most familiar members are your logical left brain and intuitive right brain. The other members are the emotional heart centre and the centres of our ‘gut feelings’ and instinctive reactions. These areas create the powerful urges to avoid and survive danger and to seek out physical pleasure and thrills. Real world point Consider for a moment how deeply emotions and instincts drive and can also veto the decisions our brain | 20 | Aging Matters

makes. Think of the power of feelings like; ‘I need a holiday’ (or a martini, or a cake) and how ‘good for you’ New Year resolutions quickly get forgotten if your head does not get ‘in charge’ of your emotions and instincts. It will be useful to sketch a plan of a committee table with these members because this provides a familiar and useful reference point. The position to date is that your committee has been exposed to hundreds of professionally produced consumer presentations. These include all the adverts you have ever seen for retirement investments, homes, and other life choices. Now it is time for me, Richard, a 73-year-old advocate, to present a different view, one that I argue is more truthful, scientifically accurate and ‘real world’. I will then outline

Before we start, here is a 4-point recap: ► 1. On one side of the Scales of Judgement is the advertised and promoted view of later life that most people follow. To balance the scales, I invite you to look at your own

Because this magazine has the sensible policy of limiting articles to 2500 words, please see this as an opening address or what judges call ‘a skeleton argument’.

gracious living. Now ask your logical ‘scientist’ mind to dispassionately observe how things really are. This observation may reveal Personal best reached at 18 Decline starts at 37

100

Vitality/Ability %

LIVING LONG AND STRONG - CHALLENGING THE CONSUMER MINDSET

Average age of death 78

choices and decisions that can help you avoid the pitfalls and maximise the benefits. To recap: The case outlined in this article is to counterbalance consumerism. The aim is to enable the committee that you Chair to reach a fully informed and balanced decision that all of ‘You’ support and understands. I propose this approach because I have seen and experienced it being used to make many important decisions and it works reliably and well. This adversarial debate method is used in courts of justice to find the truth, in Parliaments and in Congress to consider laws and in academic debate and tribunals. It’s the standard, best practice way of deciding all matters of real consequence in our lives.

observations and experiences of what happens on this road and where the road leads to. ► 2. I will then invite you to look at the less commercial and nonconsumer road, the road much less travelled, and look at what happens to people on that and where it leads to. ► 3. Hearing and weighing my arguments and your own life-evidence enables you to start making a balanced judgement about the direction your life is on now, the life your head, heart, and gut all really want and how to make any changes that ‘all of you’ wants. ► 4. Just to be clear, I am adding weight onto the side of the scales that people tend to overlook. But you can weigh and judge the relevance to your own life.

Age

100

Figure 4: Average Age related rate of decline curve

So, with a judge’s wig, and robe on let’s start:

significant self-deception that contributes to premature and avoidable mental and physical decline. This in turn leads to premature disability, dependency, and death. An informal term for this sequence is ‘circling the drain’. The main self deceptions are:

To understand the professionally promoted view; the road most travelled, look at adverts for senior living, pensions, and anything else related to the ‘silver economy’. Pictures of happy couples in fields, on trail bikes, walking on beaches and of fit silver haired people looking out at a sunset with a surfboard beside them. The theme is retirement, comfort and/ or natural, luxury or

► that retirement is good and to be welcomed, ► the idea of our ‘Golden’ Years, ► that health is and should be a consumer experience, ► that you can outsource decision making regarding your mental and physical vitality to medical experts, (i.e., the doctor always knows best), ► that healthcare providers focus on health and that, ► we should always accept medical advice. Aging Matters | 21 |

skeleton arguments for the other side of the scales. 1. Retirement is lethal. To retire means to retreat and our bodies and minds take in this message and act to fulfil the command. Twenty years ago, a report from the US military looked at 10,000 retired officers. Those that simply retired lived an average of 7 years. Those that had a second career or an absorbing interest or mission, lived an average of 17 years. 2. Thoreau observed: ‘The mass of people live a life of quiet desperation’, to which was later added; ‘and die with their song still inside them’. 3. Restoring and Maximising Health and Vitality is no more a consumer

experience than gaining an education, wisdom, physical performance or building a career. All benefit from competent and honest advice and help. All are creation and co-creation experiences, certainly not consumer experiences. Most consumer ideals are fantasies spun by interest groups that focus on the law rather than justice and truth. ‘A pill for every ill’ is one such fantasy. The reality is that adverse interactions between correctly prescribed drugs, mainly for age related conditions, are certainly the fourth and may be the third largest cause of premature disability and death in the USA and other Western countries. 4. Healthcare providers do not focus on helping you to stay well above the average levels for health and vitality for people your age. They treat the symptoms of sicknesses. They use the term ‘medical conditions’, which generally means symptoms

that cause people to fall below the age-related decline curve. (See the graphs). 5. It could also be argued that Medical Ethics are not being followed. A well-known Ethic is Patient Autonomy which states specifically that all competent patients have the right to choose or refuse any treatment. The other famous Ethic ‘first do no harm” follows on to say, ‘second be cautious, third attempt a cure’. Also relevant is the Ethical and Legal requirement on any healthcare provider to gain your informed consent before any treatment or examination. To properly exercise this right, you need to know what to do with the information. How this can benefit you With competent and honest help, you can use the above points to start to look at the likely ROI (return on investment) and other rewards in your own life, and how to tip the balance in your favor.

100

Vitality/Ability %

Here are

LIVING LONG & STRONG - CHALLENGING THE CONSUMER MINDSET

Flatten the Decline Curve

Average

Extension

0 50

Age

100

Your investment is the thirty or more years of life energy that you put into your career, business, and family. That dedication, essentially deferment of gratification, got you where you are today. Now look again at the graph of the age-related average rise and fall of physical ability to perform and enjoy the world. How much time and energy do you have to enjoy the fruits of your 30+ years labour? The zero line is death, so I suggest that you really want to be looking at 20% or more above that. You will see that at age 50 the average person is down by 30% on their maximum. Here is a check: How long can you dance and how far can you run compared to when you were 20? At 60 the graph shows a 50% decline, use the same check. If you don’t agree with this graph, then draw your own curve that you can justify to yourself. The mental ability and stamina graph shows that once people get past a certain point, it’s essentially game over. Are these sad endings inevitable? No, and there is plenty of evidence to prove it. Look at Warren Buffet and Charlie Munger, both in their 90s and still running a huge investment corporation. Look at Queen Elizabeth of England, married and working since her 20s, now in her 90s and only now handing over some responsibilities. You see University Professors in their

70s and 80s still working because they love their work. They learned about the results of retirement from colleagues who took that route. Observe, record, and do the numbers. Better still do this as a group, share the work, the knowledge, and the benefits.

relax and be comfortable’, you have earned it, ‘enjoy the luxury of your retirement’. You can greatly improve your results if you crowdsource the real-world results of different treatment and prevention choices. This can be done by making your experience

Quality of Leadership Competitive Advantage

LIVING LONG & STRONG - CHALLENGING THE CONSUMER MINDSET

- Mental Speed - Mental Stamina - Seeing Reality

Figure 6: The mental ability/ stamina effectiveness.

How to get the benefits and enjoy the process First, don’t try and do it alone. You are at best half as likely to succeed on your own, more likely one quarter. Success is far more likely if you crowdsource both the problem and the solution. The military concept of Esprit de Corps shows the power of single focus groups, of bands of brothers. It is the decider of many battles and can decide the outcome of your battle against the siren song of ‘just

part of a group activity, the scientific term is an observational study.

Figure 5: Potential quality of life gained by flattening the age-related decline curve.

| 22 | Aging Matters

Aging Matters | 23 |

LIVING LONG & STRONG - CHALLENGING THE CONSUMER MINDSET

Second don’t try to just benefit yourself. It’s more fun to be known and to see yourself as generous than as a meanie or a miser. Knowledge is a unique form of wealth because you can give all your knowledge away and keep all of it. In fact, you generally end up getting more than you had, a huge benefit to all involved. I am running this process right now. I am old enough and rich enough to retire, but intend I keep doing work I love. A simple and significant way to benefit others and yourself. Offer to share the knowledge you gain to help older owners of small to medium sized enterprises (SMEs) in your area. Making this offer will benefit you, the owners, all their employees and your country overall, here is why: SMEs are the foundation of the economies in most countries of the world. There are 30 million SMEs in the USA, and the average age of owner managers is 50 which means that 15 million are older. SMEs employ half the private sector workforce and generate half the gross domestic product. Many SME owner-managers have been in real trouble since March 2020 and for some it is getting worse. Lockdown problems have now been replaced by a host of new and more complex problems that are entirely outside their experience. Artificial Intelligence, | 24 | Aging Matters

machine learning, new and aggressive business models by huge internet-based companies and capital funds, all of them have created a completely new and fast changing playing field which has turned into a tech dominated battlefield. Older managers of good and honest value-creating companies have traditionally relied on experience to compensate for loss of sharpness and stamina. Now they cannot rely on that experience, many feel lost, stressed, and worse. You can help these people to raise their game to cope with the exponential change that is now on us all and is going to keep accelerating. SME owners will be motivated because their entire life’s work is under threat along with their own health and survival and that of all their employees. In their favour is the fact that they do not see themselves as consumers, and they will already know how to evaluate risk and reward, to get a return on investment and how to make judgements and decisions in a balanced and measured way. SME owners may feel they are too busy to even look at anything new. They may assume that if anything can be done, they would already know about it. Neither is true and you will soon be able to show them quick wins to help them see what flattening and then reversing their decline curve can achieve.

LIVING LONG & STRONG - CHALLENGING THE CONSUMER MINDSET

Quick wins are never permanent solutions, but they do create a strong first impression. You will be able to show some of those within a week. A surprisingly good first experience is often enough to make even the most overwhelmed business owners change their viewpoint and then the trajectory of their future. Some quick wins that also have long term benefits are covered in the article with Dr. Ward Dean regarding enhancing mental performance, (see V3 ISSUE 39 2021 edition of Aging Matters™). The work and findings are over 30-years old and some of the products had been in use by military units well before then. For readers outside the USA, there are 6 million SMEs in the UK and 22 million in Europe, most have the same problems. If half these SMEs fail that could take 25% off the GDP off their countries and ruin the lives of millions of employees whose financial stability also depends on the performance, balance, and stamina of these older managers. This will be a disaster and you can help avoid it and be a real hero and have fun and purpose in your life. This can put your life trajectory onto a very different and inspirational graph. Please look objectively at the maxim below and consider the likely result of doing nothing. If you do what most people do, you’re going to get what most people get!

will likely end up as lamb chops.

Summary In closing: let me leave you to also consider and discuss the validity of these three maxims.

The alternative need not be a Lion or another predatory animal. The alternative can be a fit, agile, and adaptive mountain sheep. They are independent and self determining and live high on mountains where the views are wonderful. So, it doesn’t matter what people call you, or how big your teeth and claws are, it’s your attitude and life you choose that make the difference.

● If you don’t stand for something, you will fall for anything. ● People who want to outsource their thinking are the lawful prey of people who seek to control what they think and do. ● And the highly illustrative: If you act like a sheep, you

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Please ask your heart and gut to speak to you about how they feel and ask your soul who is always there as an observer.

Ed. The author of this article welcomes your comments or suggestions; to enter into a discussion with Richard please email: Richard@antiaging-systems.com

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Aging Matters | 25 |

REDUCING TOXIC HEAVY METALS

Subtle signs of heavy metal toxicity While signs of acute toxicity are easier to spot (severe cramping, vertigo, vomiting, a green color in feces, difficulty breathing, impaired motor and cognitive skills, etc.), more subtle signs that you need to detox heavy metals are:

By Will Block Metals such as arsenic, cadmium, lead, and mercury have no beneficial role in human biological functions1. Moreover, they and other heavy metals — those with relatively high densities, atomic weights, or atomic numbers — contribute to noncommunicable chronic diseases. These metals have been increased in our bodies by industrial and anthropogenic activities, as well as modern industrialization. The industrial activities of the last century have caused massive increases in human exposure to toxic heavy metals (THM)2. Nevertheless, some orthodox physicians deride claims of any benefits for various therapies, belittling the concerns of health-conscious people worried about potential adverse effects from heavy metals (HM). Dangerous at any level It is now clear that low levels of HMs—even at levels that were once considered “safe”—are, in fact,

highly dangerous. Evidence of the toxic effects of these metals as they accumulate in the body over time is very strong. Scientists have conscientiously sought methods to remove them from the body. That process is called chelation. Chelation grab Chelation means “to grab” or “to bind.” When EDTA (ethylenediaminetetraacetic acid), a leading chelator, is inside the veins, it “grabs” heavy metals and helps remove them from the body. EDTA is a synthetic amino acid food preservative that has been used for nearly 60 years to clinically treat heavy metal toxicity and chronic degenerative diseases— especially, cardiovascular disease and cancer. Nonetheless, as already stated, some scientists believe that except as a treatment for lead poisoning, chelation therapy is controversial and unproved. This is due to the failure of the Center for Disease

| 26 | Aging Matters

Control to define other illnesses as caused by HMs. Poisoning restriction While novel drug targets for chronic disease are eagerly searched for, potentially helpful agents that aid in detoxification of toxic elements have largely been restricted to covert acute poisoning. As a natural process, chelation occurs when multiple coordination bonds between organic molecules and metals are broken. This is very common in the body and at the heart of enzymes with metal cofactors such as copper or zinc. Also, the peptides glutathione and metallothionein chelate both essential and toxic elements as they are sequestered, transported, and excreted. Enhancing natural chelation detoxification pathways, as well as use of pharmaceutical chelators against HMs have been reviewed3.

● fatigue ● headaches ● acne ● poor digestion/ bloating/gas ● compromised ability to digest fats ● female problems (hormones, infertility, preeclampsia) ● excess sweating

and cancer. As the 2013 article in Scientific World Journal explains (already cited): Historical adverse outcomes with chelators, lessons learned in the art of using them, and successes using chelation to ameliorate renal, cardiovascular, and neurological conditions highlight the need for renewed attention to simple, safe, inexpensive interventions that offer potential to stem the tide of debilitating, expensive chronic disease.

and safety characteristics compared to other chelating substances. DMSA’s watersolubility, oral dosing, large therapeutic window, and low toxicity make it the chelator of choice for many applications.

Orally-administered DMSA

Approximately 20% of orally administered DMSA is absorbed from the gastrointestinal tract, although this is two-four times the percentage of EDTA. It is believed that one of the sulfhydryls in DMSA binds to a cysteine molecule on albumin, leaving the other sulfhydryls to chelate metals.

DMSA (dimercaptosuccinic acid) is a sulfhydrylcontaining, water-soluble, non-toxic, orally administered metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. More recent clinical use and research substantiates this compound’s efficacy and

In addition to mercury, lead, arsenic, cadmium, aluminum, nickel, uranium, thallium, there are other definitions that include manganese, iron, lithium, zinc, and calcium (yes, under certain conditions very high levels of even essential minerals can become dangerous).

safety, and establishes it as the premier metal chelation compound, based on oral dosing, urinary excretion,

Most of these can be taken orally, some regularly, some occasionally.

● gaining weight just around the waist ● severe food cravings ● middle-of-thenight insomnia ● aching joints ● mood swings ● and the list goes on … Left unchecked, HMs can cause not only misery but serious disease including Alzheimer’s, dementia, multiple sclerosis, Parkinson’s,

Aging Matters | 27 |

REDUCING TOXIC HEAVY METALS

Heavy metals in some foods

and behavior problems, cardiovascular and kidney diseases, decreased fertility, hypertension and cancer. The effects of chronic exposure to low levels of lead is a concern.

Where do heavy metals come from? Here are some of the heavy metals causing toxicity in our modern environment and their common sources:

No safe level of lead

► Lead (auto exhaust, root canals, building materials, water, some teas). ► Mercury (dental fillings, vaccines, contact lens solution, seafood). ► Cadmium (cigarettes, batteries, hydrogenated oils, coffee). ► Arsenic (conventional poultry and eggs). ► Aluminum (deodorant, vaccines, cookware, some teas). ► Thallium (added to gasoline). ► Bismuth (makeup, medicines). The list certainly goes on, but these are a few of the key players.

Mind your sources When you want to limit heavy metals exposure you cut down on meats and seafood. Of those that you do eat, make sure you use reliable sources. Also, use holistic dentistry, natural deodorants, and beauty products, and avoid hydrogenated oils. Unfortunately, we may not have as much control over other things on the list. Foods that remove HMs What foods can help remove heavy metals from the body? As you’ll learn more about below, foods to include in a heavy metal detox include leafy green veggies, other non-starchy veggies, herbs, spices, algae and other superfoods, and bone broth. Lead increases vascular disease and overall mortality Acute lead poisoning (shortterm, high exposure) causes symptoms of abdominal pain or “lead colic,” cognitive deficits, peripheral neuropathy, arthralgias, decreased libido and anemia.

| 28 | Aging Matters

Research shows that it can be diagnosed by a characteristic “lead line” at the junction of the teeth and gums, and by high blood lead levels (over 80 micrograms per deciliter)4. Yet, the effects of chronic exposure to low levels of lead are not easy to determine. Long-term exposure to low levels of lead may result in the gradual accumulation of lead and the development of a number of disorders and diseases, including learning and behavior problems, cardiovascular and kidney diseases, decreased fertility, hypertension and cancer. Effects of low levels of lead To determine the effects of chronic exposure to low levels of lead, data from the massive Third National Health and Nutrition Examination Survey (NHANES-III) was explored5. NHANES data is a stratified, multistage probability sample of the civilian noninstitutionalized individuals within the United States. This study demonstrates the potential dangers of social and environmental exposures to liver health. No level of lead

Figure 7: A bluish line in the gum line is one sign of an over exposure to lead. Called the ‘Burton line’ after its discovery by Henry Burton in 1840.

exposure is safe, and even very low levels of exposure may significantly harm the health of individuals. Lead exposure may come about due to exposure from lead-contaminated paint, water, jewelry, candy, soil, and dust. The role of chelation therapy Chelation therapy provides benefits by reducing the body burden of HMs, resulting in improved physiological functioning and better health. The two most widely used oral chelating agents are EDTA and DMSA. DMSA—A chelator since the 1950s DMSA (meso-2,-3dimercaptosuccinic acid) is a sulfhydryl-containing, water-soluble, non-toxic, orally administered metal chelator that has been in use as an antidote to heavy metal toxicity since the 1950s.

DMSA is the premier oral metal chelator for mercury and is effective for other heavy metals as well. DMSA’s water-solubility, oral dosing, large therapeutic window and low toxicity make it the chelator of choice for many applications. Lead increases certain cancers and overall mortality Lead poisoning has long been recognized as a health hazard. This HM has been historically used in a number of industrial processes. These include the manufacture of batteries, paints, and as an additive in gasoline. However, the effects of chronic exposure to low levels of lead are more difficult to determine. Longterm exposure to low levels of lead may result in the gradual accumulation of lead and the development of a number of disorders and diseases, including learning

There is no safe level of lead. Lead at any level contributes to increased disease-related mortality— especially from heart disease and cancer. Lead is still found in millions of pre1940s homes. Lead toxicity impairs calcium uptake and utilization and interferes with calcium-facilitated cellular metabolism. Lead is especially toxic to the central nervous system, as evidenced by its harmful effects on mental development and intelligence in children, who are especially susceptible to lead’s deadly effects. For example, behavioral disorders such as attention deficit disorder (ADHD) have been attributed to lead exposure. Mercury and cardiovascular disease Until recently, the notion of treating heart disease with chelation therapy—one of the mechanisms of which is to remove heavy metals— was scorned by the medical

Aging Matters | 29 |

REDUCING TOXIC HEAVY METALS

cardiovascular disease were found in mercuryexposed workers, and mercury levels in hair predicted the progression of carotid atherosclerosis in a longitudinal study. An article in the 2002 New England Journal of Medicine, found that mercury levels were directly associated with the risk of myocardial infarction

REDUCING TOXIC HEAVY METALS

promotes the production of free radicals … and may bind selenium [so that it] cannot serve as a cofactor for glutathione peroxidase. Mercury may … inactivate the antioxidant properties of glutathione, catalase, and superoxide dismutase.” The New England Journal of Medicine went on: “The

establishment. Nevertheless, alternative therapy has overruled that idea. In several recent studies, mercury has been found to be connected to CVD. In one, a systematic review of published studies and a meta-analysis of the results to examine the associations between chronic Hg exposure and CVD outcomes was run6. In this study, mercury was found to be associated with allcause mortality and fatal/nonfatal ischemic heart disease. Mercury compounds also promote platelet aggregability and blood coagulability7. They also inhibit endothelial-cell formation and migration and affect apoptosis and the inflammatory response. Increased rates of | 30 | Aging Matters

for the patient, dentist and technician. Mercury vapor continues to be released as the patient chews, brushes, or drinks hot beverages, after which it is inhaled into the lungs and enters the bloodstream. Studies have shown a direct correlation between the number of amalgam fillings and mercury concentration in blood and urine. Amalgam removal reduces bloodmercury levels. DMSA treatment results in the greatest urinary excretion

of mercury, compared to other heavy metal chelators, as well as being the most effective at removing mercury from the blood, liver, brain,

spleen, lungs, large intestine, skeletal muscle and bone. Mercury excretion is greatest in the first eight to 24 hours

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(heart attacks), and that this partially offset the protective effects of DHA derived from eating fish8. They editorialized: “The notion that methylmercury contributes to cardiovascular disease is certainly a testable hypothesis and one that warrants further testing.” Continuing: “Mercury, fish oils, and the risks of myocardial infarction… Mercury may promote atherosclerosis and hence increase the risk of myocardial infarction in several ways. Mercury

notion that methylmercury contributes to cardiovascular disease is certainly a testable hypothesis and one that warrants further testing.” Fish consumption is directly associated with methylmercury levels in blood and hair.12,13 Mercury in dental amalgams is probably the major source of inorganic mercury exposure in humans.14 The most commonly used dental amalgam material contains approximately 50% liquid metallic mercury. Thus, amalgam preparation and placement results in mercury vapor exposure

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REDUCING TOXIC HEAVY METALS

after ingestion of DMSA. In animal studies, DMSA was the most efficient chelator for brain mercury, removing two-thirds of the brain mercury deposits.

EDTAPro™ A premium chelator, particularly effective for lead reduction

Safety of DMSA DMSA is very safe, and usually causes few side effects. Some may experience slight gastrointestinal distress or itching, when higher doses are used. As with any chelating agent, DMSA can cause deficiencies of copper, manganese, molybdenum, and zinc, especially if they are not replaced by supplementation. DMSA doesn’t directly bind magnesium, cysteine, or glutathione, but heavy metal detoxification can result in depletion of these nutrients as well. Likewise, EDTA can also remove zinc and selenium, and therefore whilst chelating those heavy metals it is always prudent to supplement with a multi-mineral.

EDTA (Ethylenediaminetetraacetic acid) is a type of vinegar molecule found in some plants and it is used widely within the food industry. It can gently detox many heavy metals but has a particular affinity for lead.

Figure 8: Crystalline citric acid, monohydrate. A weak organic acid with white crystals. Occurs in citrus fruits. Used as acidifier, flavoring and chelating agent.

Dosage recommendations Dosage recommendations for DMSA are quite different depending on your source. In Physicians’ Desk Reference and other conventional medical publications, the recommendation is 10 mg per kg every eight hours for five days; then reduce the dose to twice daily for two more weeks, off for two weeks, and repeat as necessary. As far as EDTA is concerned, the doses are often in the

range of 500 mg to 1000 mg daily taken over several weeks and repeated as necessary. Of course, it is always best to do a before and after heavy metal test, to see what is afflicting you and how it is being reduced.

EDTAPro™ 60x 500 mg capsules

$19.99

Credit card payments available

For further details visit: www.antiaging-systems.com

DMSAPro™

Note: Heavy metal detoxification is a long-term process, as the heavy metals in the body compartments are in a constant state of equilibrium.

The ultimate mercury chelator DMSA, (Dimercaptosuccinic acid) is widely recognized as one of the most potent chelators, and it is particularly effective in reducing mercury levels. It is on the WHO list of essential agents and has been in use since the 1950s.

References: 1. Sears M. Chelation: Harnessing and Enhancing Heavy Metal Detoxification — A Review. Scientific World Journal 2013 Apr 18; 2013:219840. 2. Balali-Mood M, Naseri K, Tahergorabi Z, et al. Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic. Front Pharmacol. 2021; 12:643972 3. Rahman Z, Singh VP. The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview. Environ Monit Assess. 2019 Jun 8;191(7):419. 4. Marsden PA. Increased lead burden—Cause or consequence of chronic renal insufficiency? New England J Med 2003, 4:345-6. 5. Obeng-Gyasi E. Cumulative effects of low-level lead exposure and chronic physiological stress on hepatic dysfunction-a preliminary study. Med Sci (Basel) 2020 Aug 5;8(3):30. 6. Hu XF, Lowe M, Chan HM. Mercury exposure, cardiovascular disease, and mortality: A systematic review and dose-response meta-analysis. Environ Res. 2021 Feb; 193:110538. 7. Lohren H, Bornhorst J, Galla HJ, Schwerdtle T. The blood-cerebrospinal fluid barrier--first evidence for an active transport of organic mercury compounds out of the brain. Metallomics. 2015 Oct;7(10):1420-30. doi: 10.1039/c5mt00171d. Epub 2015 Aug 12. PMID: 26267314. 8. Bolger PM, Schwetz BA. Mercury and Health, New England J Med 2002, 347:22, 1735-6.

| 32 | Aging Matters

DMSAPro™ 60x 100 mg capsules

$34.99

For further details visit: www.antiaging-systems.com Note: US$ prices are subject to shipping and handling (and additional taxes where appropriate). Disclaimer: All educational information is provided under the IAS terms and conditions (which may change without notice) and does not replace the advice of your physician. Restrictions may apply in some countries.

Aging Matters | 33 |

SPOTLIGHT ACF228® - the ultimate free radical scavenger What is in it? Each capsule provides all the following: Ingredients Quantity N-acetylcysteine L-methione Di-indole-methane L-carnosine Deodorised garlic Trans resveratrol Vitamin B6 NDGA Potassium iodide Iodine Methylfolate Chromium picolinate Selenium Vitamin B12 Catalase

100 mg 100 mg 83 mg 83 mg 50 mg 17 mg 17 mg 3 mg 3 mg 2.5 mg 800 mcg 120 mcg 100 mcg 10 mcg 0.025 mg

Where does it come from?

► This unique and natural ‘antioxidant complete formula’ was the best combination found to quench free radicals,

SPOTLIGHT

Visit us at: www.antiaging-systems.com

even the most dangerous ones which include the superoxide and hydroxy radicals. ► It was 228th experiment conducted in-vivo (on humans) by Dr. Richard Lippman, (hence why it is called ACF228®).

Can-C™ Eye-drops - a breakthrough for cataract ► ‘Free radicals and the four lines of defence’ by Richard Lippman, Ph.D. Aging Matters™ magazine, issue 4, 2014. ► ‘Stay 40’ by Richard Lippman, Ph.D. Outskirts Press, 2008. ► Videos on the IAS You Tube channel, (see the media page for details).

What is in it? N-acetylcarnosine 1% plus lubricants glycerine and carboxymethylcellulose sodium. Where does it come from?

► Antiaging (free radical theory of aging). ► Antioxidant (free radical scavenger).

► Carnosine is naturally found in the human body and can be found in dark green leaves and chicken meat. ► The eyedrops are made to cGMP standards.

How is it used?

What is it used for?

► Designed for simplicity as a one a day multi-protective formula.

► Cataracts (particularly the senile type). ► Contact lens discomfort. ► Diabetes mellitus complications. ► Dry eyes. ► Glaucoma.

What is it used for?

Where can I learn more about it?

► ‘Free radicals in aging’ by Richard Lippman, Ph.D. Aging Matters™ magazine V3 I37, 2021.

► Is proven clinically effective for humans and dogs. ► A typical treatment period for humans is 5-6 months. ► Note: There is improved synergy when taken along with the specially designed Can-C™ capsules. Where can I learn more about it?

► ‘Eyesight saviors’ by Marios

How is it used?

► It is applied twice daily onto the effected eye.

BEC5® Curaderm - a truly amazing skin cream What is in it? Solasodine 0.005%. Where does it come from?

► It is extracted from the ‘Devil’s Apple’ (a relation of eggplant). What is it used for?

► BCC (basal cell carcinomas). ► Keratosis (sunspots). ► SCC (squamous cell carcinomas). How is it used?

► It is applied twice daily onto clean, dry skin and then covered with a

| 34 | Aging Matters

micropore. ► Typical end-to-end treatment times are 6-12 weeks. ► Note: It is important to use antiseptic cream daily during the healing process. Where can I learn more about it?

► Curaderm BEC5® natural non-invasive medication for skin cancers’ by Dr. Bill E. Cham. Curaderm Global Publishing, 2015. ► ‘BEC5® the skin cancer cure’ by Bill Edward Cham, Ph.D. Aging Matters™ magazine, No.1, 2013. ► Videos on the IAS You Tube channel, (see the media page for details).

Kyriazis, M.D. Profound Health Publishing, 2018. ► ‘Maintain your vision’ by Leslie Farer. Aging Matters™ magazine, Issue 6, 2015. ► ‘Can-C™ eye-drops 10-years on’ by Marios Kyriazis, M.D. Aging Matters™ magazine Issue 4, 2012. ► Videos on the IAS You Tube channel, (see the media page for details).

CentroPro™ - A brain neuroenergizer What is in it?

► Centrophenoxine, (also known as meclofenoxate). ► It is a nootropic agent, (aka a smart drug) available in 250 mg capsules. Where does it come from?

► It is a combination of two DMAE molecules, (which is commonly found in oily fish). ► The supplement is synthetically produced. What is it used for?

► Alertness. ► Alzheimer’s. ► Antiaging, (membrane theory of aging).

► Dementia. ► Memory/ recall speed improvement. ► Toxin reduction, (lipofuscin and plagues). How is it used?

► Typically, two 250 mg capsules are taken daily. ► Note: Athletes be aware it can produce a positive doping result. Where can I learn more about it?

► ‘Centrophenoxine for memory and aging’ by Professor Imre Zs. Nagy. Aging Matters™ magazine, issue 3, 2014. ► ‘Centrophenoxine, a

true-life extension drug’ by James South MA, International Antiaging Magazine, No.2, 2004. ► ‘Smart drugs and nutrients’ by Ward Dean, M.D. Smart Publications, 1991. ► Videos on the IAS You Tube channel, (see the media page for details). Aging Matters | 35 |

SPOTLIGHT

DepPro™ - For focus, concentration, and libido What is in it?

► Deprenyl, (otherwise known as selegiline HCL). ► Available in liquid form (1 drop = 1.15 mg) and 5 mg tablets. Where does it come from?

► It is a synthetically produced agent. ► It enhances dopamine levels by acting upon MAO-b. (Dopamine is manufactured in the brain from two natural amino acids: tyrosine and phenylalanine). ► Professor Joseph Knoll also suggested that it raises PEA levels and improves catecholamine sensitivity. What is it used for?

► ► ► ►

Alzheimer’s disease. Concentration/ focus. Dementia. Libido (in men).

► Life extension. ► Parkinson’s disease. How is it used?

► Parkinson’s disease doses can often be 5 mg to 10 mg daily, even up to 20 mg. ► Antiaging doses are much lower. This depends upon need and age, but adults often settle at around 1 mg to 3 mg a day, or 5 mg once or twice a week. (It is beneficial to take occasional breaks from use if not suffering with a dementia, such as a weekend off, or a week a month off). ► Note: Some drug test exams may produce a false-positive result.

GHRP2Pro™ - An oral alternative to GH injections

►

► ► ►

Matters™ magazine, issue 1, 2019. ‘Deprenyl and Alzheimer’s disease’ by Ward Dean, MD. Aging Matters™ magazine, issue 2, 2017. ‘How selegiline (deprenyl) slows brain aging’ by Professor Joseph Knoll. Bentham, 2012. ‘The brain and its-self’ by Professor Joseph Knoll. Springer, 2005. ‘Smart drugs and nutrients’ by Ward Dean, MD. Smart Publications, 1996. Videos on the IAS You Tube channel, (see the media page for details).

What is it used for?

► A combination of three bioidentical estrogens; estriol (90%), estradiol (7%) and estrone (3%). ► Specially formulated by Jonathan Wright, MD, to mimic his research that shows that the ‘average’ healthy woman produces these estrogens at those percentages.

► Menopause (female). ► PMT (premenstrual tension). ► Skincare. ► Well-being.

| 36 | Aging Matters

Where does it come from?

► Synthetically produced from foodstuffs.

Where can I learn more about it?

What is it used for?

► Antiaging. ► Body shaping, (lose fat but gain muscle). ► Physical strength enhancement. ► Sarcopenia. How is it used?

► Two tablets are taken in

► ‘Growth hormone releasing peptides’ by Richard Walker, M.D. Aging Matters™ magazine V3 Issue 36, 2020. ► ‘The story of GHRH and GHRPs’ by Richard Walker, M.D. Aging Matters™ magazine, Issue 3, 2014. ► ‘GHRP performance’ by Phil Micans, MA. Aging Matters™ magazine, issue 3, 2013.

RetinPro™

► ‘An antiaging, life extending aphrodisiac’ by Ward Dean, MD. Aging

What is in it?

► Estrogens can be produced in fat tissue, the liver, the adrenal glands, and the ovaries. ► The cream is synthetically produced to a bioidentical standard.

Growth hormone releasing peptide type-II, in 1 mg sublingual tablets.

► Videos on the IAS You Tube channel, (see the media page for details).

Where can I learn more about it?

The ultimate

Esnatri™ - Natural topical tri-estrogen cream for women.

Where does it come from?

the morning on an empty stomach. ► As they are sublingual lozenges, they are placed under the tongue to dissolve.

What is in it?

How is it used?

► It is often applied topically to a hairless area, such as under breasts, behind knees or inside elbows. ► Doses will be determined by a physician, but typically for women they can be a total dose of 2 mg applied daily from day 1 to day 25. ► Day 1 is determined by the day that is, (or would have been) the first day of the menstrual cycle.

Where can I learn more about it?

► ‘Getting the most out of BHRT’ by Jonathan Wright, MD. Aging Matters™ magazine, issue 1, 2014. ► ‘Stay young & sexy with bioidentical hormone replacement therapy’ by Jonathan Wright, MD. Smart Publications, 2009. ► Videos on the IAS You Tube channel, (see the media page for details).

ANTI-WRINKLE Skin cream

RetinPro™ contains tretinoin at 0.05% in rosemary oil, all within an airless tube that dispenses 0.75ml with each pump.

50 ml cream $34.99 Note: US$ prices are subject to shipping and handling (and additional taxes where appropriate). Disclaimer: All educational information is provided under the IAS terms and conditions (which may change without notice) and does not replace the advice of your physician. Restrictions may apply in some countries.

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www.antiaging-systems.com For further details visit: www.antiaging-systems.com Aging Matters | 37 |

SPOTLIGHT

MetPro™ - Activating AMPK and restoring insulin receptor sensitivity. What is in it?

► Metformin HCL in 500 mg scored tablets. Where does it come from?

► Synthetically produced from guanidine compounds such as goat’s rue or the French lilac. What is it used for?

► Antiaging, (neuroendocrine theory of aging). ► Cancer. ► Diabetes type-II. ► Insulin resistance. ► Lowers LDL (bad cholesterol). ► Obesity (weight loss). ► PCOS (polycystic ovarian

syndrome). ► Syndrome X. How is it used?

► Doses vary, an antiaging dose might be 500 mg daily, treatment of diabetes might be 1000 mg to 2000 mg or sometimes more daily. ► Note: As metformin is known to inhibit B12, it is prudent to take a vitamin B12 supplement concurrently.

► ‘AMPK the metabolic signaller’ by Marios Kyriazis, M.D. Aging Matters™ magazine, issue 6, 2016. ► Dr. Dean’s favorite antiaging medicine’ by Ward Dean, MD. Aging Matters™ magazine, issue 4, 2013.

► Age related macular degeneration (ARMD). ► Antiaging, (rotational theory of aging). ► Antioxidant. ► Cancer. ► Circadian rhythm improvement. ► Hormonal cyclicity regularity. ► Immunity. ► Jetlag. ► Sleep enhancement.

Where does it come from?

► Melatonin is a natural hormone usually excreted by the pineal gland. The supplement is extracted from coffee beans to a bioidentical standard. ► Zinc and selenium are minerals.

| 38 | Aging Matters

How is it used?

► The tablet should be taken between 9pm and 11pm for maximum effectiveness. It is not necessary to go to bed straightaway. ► Note: To maximise your own production of melatonin make sure you sleep in a dark room. Evidence also exists that more sunshine in the day

► They contain different combinations of short chain peptides (between 2 and 4) at 10 mg per capsule.

► All of them are extracted from food (bovine origin).

They currently represent 21 glands and tissues as listed:

► Blood vessels (Ventfort®) ► Bone-marrow (Bonomarlot®) ► Brain (CNS/ Cerluten®) ► Cartilage (Sigumir®) ► Heart (Chelohart®) ► Kidney (Pielotax®) ► Liver (Svetinorm®) ► Lungs (Taxorest®)

MZS™ - Not melatonin’s are created equal

► Each tablet contains 3 mg of melatonin, plus 8.7 mg zinc and 50 mcg of selenium, all within a unique 4-hour time release tablet produced to pharmaceutical quality (>99.5%).

Where does it come from?

► Bladder (Chitomur®)

► ‘Shielding against AGE’ by Ward Dean, M.D. Aging Matters™ magazine, issue 1, 2018.

What is it used for?

What is in it?

► Adrenal (Glandokort®)

Where can I learn more about it?

What is in it?

Nature’s Marvels™ - The epigenetic gene switches within food.

is beneficial and avoid late/ or excessive caffeine intake. Where can I learn more about it?

► ‘Melatonin stops cancer’ by Will Block. Aging Matters™ magazine, issue 35, 2020. ► ‘Reversing ARMD with melatonin’ by Phil Micans, MA. Aging Matters™ magazine, issue 2, 2019. ► ‘The rotational theory of aging’ by Professor Walter Pierpaoli. Aging Matters™ magazine, issue 1, 2014. ► ‘The use of high dose melatonin in medicine’ by Professor Jesus Tresguerres. Aging Matters™ magazine, issue 3, 2016. ► Videos on the IAS You Tube channel, (see the media page for details).

► Muscle (Gotratix®) ► Ovaries (Zhenoluten®) ► Pancreas (Suprefort®) ► Parathyroid (Bonothyrk®) ► Pineal (Endoluten®) ► Prostate (Libidon®) ► Retina (Visoluten®) ► Stomach (Stamakort®) ► Testes (Testoluten®) Thymus (Vladonix®) ► Thyroid (Thyreogen®)

What is it used for?

► Adjustment/ improvement of the targeted gland or tissue, all by way of signalling via our own genes for the target to regulate itself better. ► Antiaging, (peptides in the epigenetic control of ageing). How is it used?

► Start at 2-capsules a day for 30-days. ► Then reduce to 2-capsules a day for 10-days each month. ► As condition improves, the dose can drop to a maintenance of 2-capsules a day for 10-days every 3-months. Where can I learn more about it?

► ‘Forever young’ an interview with Dr. Bill Lawrence. Aging Matters™ magazine, issue 1, 2019. ► ‘The peptide bioregulator revolution’ by Marios Kyriazis, M.D. Profound Health Publishing, 2018. ► ‘Peptides in the epigenetic control of ageing’ by Professor Vladimir Khavinson. Profound Health Publishing, 2017. ► ‘The peptide human lifeextension trial’ by Leslie Farer. Aging Matters™ magazine, issue 4, 2016. ► ‘The power behind the pineal peptide bioregulator’ by Leslie Farer. Aging Matters™ magazine, issue 3, 2015. ► ‘The Russian peptide bioregulator revolution’ by Phil Micans, MA. Aging Matters™ magazine, issue 2, 2013. ► Videos on the IAS You Tube channel, (see the media page for details

► ‘Peptide bioregulators in sports and space’ by Professor Vladimir Khavinson. Aging Matters™ magazine, issue 36, 2020.

Publications for antiaging, preventative and regenerative health enthusiasts www.thelongevity.store

Aging Matters | 39 |

SPOTLIGHT

SPOTLIGHT PiraPro™ - The original nootropic, (aka smart drug)

OxyPro™ - Longevity, passion, and sex What is in it?

How is it used?

► Oxytocin at 5 mg per sublingual lozenge.

► Usually just 5 mg taken on an empty stomach 15-30 minutes before sex. ► Other treatments may require more daily applications, see Dr. Thierry Hertoghe’s oxytocin book for precise details. ► The sublingual lozenges must be allowed to be dissolved under the tongue.

Where does it come from?

► It is a hormone produced naturally in the pituitary gland. ► The product is manufactured synthetically to a bioidentical standard. What is it used for?

Where can I learn more about it?

► Ejaculate (men). ► Fibromyalgia. ► Relationships (bonding). ► Relaxation (calming). ► Sex (heightened orgasm, particularly for women). ► Sociopathy.

Matters™ magazine, issue 5, 2015. ► ‘Hormone handbook V2’ by Thierry Hertoghe, MD. International Medical Books, 2014. ► ‘Passion, sex, and longevity- the oxytocin adventure’ by Thierry Hertoghe, MD. International Medical Books, 2010. ► Videos on the IAS You Tube channel, (see the media page for details).

► ‘The Atlas of Endocrinology V2’ by Thierry Hertoghe, MD. International Medical Books, 2019. ► ‘Passion, sex, and lifespan’ by Thierry Hertoghe, MD. Aging

► A synthetically produced agent derived from GABA.

Where can I learn more about it?

What is it used for?

► ► ► ►

► ‘Smart drugs and nutrients’ by Ward Dean, MD. Aging Matters™ magazine, issue 4, 2012. ► ‘Smart drugs and nutrients’

Alzheimer’s. Awareness/ consciousness. Dementia. Memory and cognition.

Where does it come from?

A British made NMN conforming to ISO 9001 and of pharmaceutical quality (>99.5%) designed by Dr. Elena Seranova.

► Progesterone is made in the ovaries, the adrenals and in the placenta. ► The cream is synthetically produced to bioidentical standards. What is it used for?

► Accompanying an estrogen treatment for women. ► Menopause (female). ► Osteoporosis (female). How is it used?

► Applied topically, (often to a hairless area, such as under breasts, behind

$29.99 $59.99

knees or inside elbows), the dose is determined by a physician. A typical quantity of progesterone for women is 25 mg to 30 mg, used starting on days 10 to 15 and taken through day 25. ► The starting date is varied according to the timing of each woman’s ovulation when she was cycling. ► If this timing is not known, a starting date is from day 10 to 15 is arbitrarily chosen.

► ‘Stay young & sexy with bioidentical hormone replacement therapy’ by Jonathan Wright, MD. Smart Publications, 2009. Videos on the IAS You Tube channel, (see the media page for details). ► Videos on the IAS You Tube channel, (see the media page for details).

Where can I learn more about it?

► ‘Not all progesterone’s are created equal’ by Dr. Nyjon Eccles. Aging Matters™ magazine, issue 37, 2021. ► ‘Getting the most out of BHRT’ by Jonathan Wright, MD. Aging Matters™ magazine, issue 1, 2014.

For more information visit:

www.antiaging-systems.com Credit card payments available

For further details visit: www.antiaging-systems.com | 40 | Aging Matters

► A typical dose is 1600 mg once or twice daily.

Where does it come from?

► Bioidentical progesterone at a 5% strength.

Introducing NMNBio:

How is it used?

What is in it?

Dr David Sinclair has pointed out from his research that improving NAD levels has a significant effect upon health and well being, suggesting that it can help merge healthspan to lifespan.

30x 500 mg capsules $69.99 introductory offer

► Piracetam 800 mg per scored tablet.

by Ward Dean, MD. Smart Publications, 1991. ► Videos on the IAS You Tube channel, (see the media page for details).

ProgestPro™ - Natural topical progesterone cream for women.

NMN to improve NAD levels

30x 250 mg capsules $34.99 introductory offer

► Motivation (idea creation). ► Travel/ altitude sickness.

What is in it?

The World’s most comprehensive antiaging resource

Aging Matters | 41 |

SPOTLIGHT

Thyroids - Supporting the hypothyroid epidemic What is in it?

► The natural versions (of porcine origin) contain T3 and T4, but also the ‘forgotten’ thyroids of T1 and T2. These are also known as desiccated thyroids. ► A wide range of tablets in different doses are available. ► T3Pro™ contains synthetic T3, otherwise known as triiodothyronine. Where does it come from?

► The thyroid hormones are produced in the thyroid gland, which is stimulated by the release of TSH from the pituitary, which in turn is stimulated by the release of TRH from the hypothalamus. ► The natural versions are obtained from porcine thyroids.

► The synthetic T3 is manufactured to bioidentical standards. What is it used for?

► ► ► ► ► ►

Fatigue. Hypothyroidism. Sleep disorders. Temperature control. Weight loss. Well-being.

How is it used?

► Doses depend upon the individual patient’s need and will vary depending on whether a synthetic is being used, or a natural thyroid.

► Note: A conversion table to compare the natural and synthetic versions is provided here Where can I learn more about it?

► The hypothyroid epidemic’ by Rick Wilkinson, MD. Aging Matters™ magazine, issue 4, 2014. ► ‘How to improve your thyroid and your adrenals’ by Richard Lippman, Ph.D. Aging Matters™ magazine, issue 2, 2012. ► ‘Hypothyroidism, the unsuspected illness’ by Dr. Broda Barnes. Harper Books, 1976.

Equivalents (mg)

Dose of T3 (lithyronine) (mcg)

0.5

12.5

100

130

200

300

260

100

400

325

125

500

Dose of Desiccated thyroid (grains)

Dose of T4 (levothyroxine) (mcg)

Youth Gems® - The topical peptide bioregulators for modern skincare What is in it?

► Each version contains 4 synthetic peptide bioregulators, specifically: blood vessels, cartilage, thymus and the pineal. ► In addition, there are numerous other beneficial natural agents such as ginseng, olive oil, raisin oil, argon oil, soya oil, jojoba oil, hyaluronate, green tea extract, cocoa, almond, vitamin E and chamomile extract. Where does it come from?

► They are a combination of 4 synthetically produced peptide bioregulators and natural oils and agents, (as listed). | 42 | Aging Matters

► Available in a day cream, a body milk, and a face serum.

► Strengthens collagen to improve skin elasticity and tone.

What is it used for?

How is it used?

► Anti-inflammatory to reduce puffiness. ► Antioxidant to prevent infection, skin damage and faster wound healing. ► Enhances the blood microcirculation to create a fresh, glowing appearance. ► Increases protein synthesis to aid the skin’s repair processes and reduce dry, dead skin. ► Regulates metabolic pathways to normalize lipid peroxidation for a cleaner, smoother uniformity to the skin’s surface via enhanced moisturization.

► Apply sparingly to the skin once a day. ► The day cream is designed for the face and neck. ► The body milk is designed for the arms, hands, and legs etc. ► The serum is the intensive treatment for fine lines and wrinkles.

• The World’s most comprehensive antiaging resource • Global perspective • More than 30 years' experience

www.antiaging-systems.com

Aging Matters | 43 |

Media Page of them from leading professionals in the field.

Welcome to the media page; here you will find links to videos and podcasts that we hope are of interest to you. Many of them are located on You Tube under the Antiaging Systems channel. Please subscribe to stay up to date with new uploads as they occur.

Often, they are interviews, occasionally they are PowerPoint presentations and sometimes they are even professionally made clips. We even have recordings from lectures given at conferences.

These videos and audio files are specific to age-related disorders and occasionally actual medical conditions, they highlight the latest thinking and approaches, many

Mercury – the smoking gun! See for yourself how mercury is released from dental amalgams, either by chewing or consuming hot drinks. This video was made by the International Academy of Oral Medicine and Toxicology.

We hope you like the selection we have made out for you here.

https://www.youtube.com/watch?v=Bw94F94FZqA

We hope you like the selection we have made out for you here.

Garry Gordon, M.D. presents a series on various methods for oral detoxification.

www.antiaging-systems. com/videos/

Dr. Garry Gordon has been called ‘the father of chelation.’ This is due to his immense experience in both utilising chelation therapies on himself, his patients, and his training of thousands of physicians over decades in how to utilize it effectively. Here he delves into numerous substances and their uses over three parts.

www.youtube.com/watch?v=acqzzMh3fNU www.youtube.com/watch?v=xTNxsfUUegQ www.youtube.com/watch?v=nDcD7RLIqyI

Richard Wilkinson, M.D. describes why thyroid hormones are a fundamental therapy for antiaging. Dr. Rick Wilkinson is a thyroid expert and a pupil of the famous Dr. Broda Barnes who wrote the book; ‘hypothyroidism, the unsuspected illness.’ Today, with so many adults suffering from a weak thyroid it might be called an epidemic. Here, you can listen to Dr. Wilkinson on how to benefit from and maintain a healthy thyroid.

www.youtube.com/watch?v=LrDO8nOVyqs&t=8s | 44 | Aging Matters

For more informaton on Nature's Marvels™

products visit naturesmarvels.com Note: US$ prices are subject to shipping and handling (and additional taxes where appropriate). Disclaimer: All educational information is provided under the IAS terms and conditions (which may change without notice) and does not replace the advice of your physician. Restrictions may apply in some countries.

For further details visit:

Credit card payments available

www.antiaging-systems.com Aging Matters | 45 |

Antiaging Systems www.antiaging-systems.com is your comprehensive resource for

information about all the leading commercially available antiaging, preventative, and regenerative products available today.

Visit www.antiaging-systems.com

and find articles, videos, audio-files, all referenced with a guide of where to obtain your needs. Currently the site covers topics related to all the following products:

BOOKS ► Atlas of Endocrinology V2 by Thierry Hertoghe, MD ► Passion, Sex & Oxytocin by Thierry Hertoghe, MD ► Peptides in the Control of Ageing by Prof. Khavinson ► Testosterone Therapy for Real Gentlemen by Dr. Hertoghe

► Eyesight Saviors by Marios Kyriazis, MD ► Patient Hormone Handbook by Thierry Hertoghe, MD ► Physician Hormone Handbook V2 by Thierry Hertoghe, MD

► Natural Skin Cancer Treatments by Bill Cham, PhD ► Peptide Bioregulator Revolution by Dr. Kyriazis ► Reversing Physical Aging V1 by Thierry Hertoghe, MD

DIAGNOSTICS ► Bio-Clip™ CUFF

Aldosterone (AldoPro™) Desmopressin (Minurin®) DHEA (DHEAPro™) Estrogens (Esnatri™) HCG (HCGPro™) Hydrocortisone (HydrocortPro™)

► Sermorelin (SermPro™)

► ► ► ► ►

Melatonin (MelaMaxPro™) Melatonin (MZS™) MSH2 (MSH2Pro™) Oxytocin (OxyPro™) Pregnenolone (PregPro™)

► ► ► ► ► ► ► ►

Kidney (Pielotax®) Liver (Svetinorm®) Lungs (Taxorest®) Muscle (Gotratix®) Ovaries (Zhenoluten®) Pancreas (Suprefort®) Parathyroid (Bonothyrk®) Pineal (Endoluten®)

► ► ► ► ► ►

Prostate (Libidon®) Retina (Visoluten®) Stomach (Stamakort®) Testes (Testoluten®) Thymus (Vladonix®) Thyroid (Thyreogen®)

PEPTIDE BIOREGULATORS (synthetic source, includes sublingual’s) ► Blood Vessels (Vesugen®) ► Cartilage (Сartalax®)

► CNS/ Brain (Pinealon®) ► Liver (Ovagen®)

► Lungs (Chonluten®) ► Thymus (Crystagen®)

► Deprenyl (DepPro™) ► Hydergine® (HyPro™) ► Modafinil (ModaPro™)

► Picamilone (PicPro™) ► Piracetam (PiraPro™)

► EDTA (EDTAPro™) ► GH3Pro™ (Gerovital-H3®) ► Ivermectin (IvermectinPro™) ► Metformin (MetPro™)

► ► ► ►

► JointPro™ cream (peptide) ► OraltidePro™ peptide mouthwash

► RetinPro™ (0.05% tretinoin) ► Youth Gems® (peptide creams)

SMARTS ► Adrafinil (AdraPro™) ► Centrophenoxine (CentroPro™)

► 4MU (4MUPro™) ► Aminoguanidine (AminoPro™) ► Dasatinib (DasaPro™) ► DMSA (DMSAPro™)

HORMONES ► ► ► ► ► ►

Adrenal (Glandokort®) Bladder (Chitomur®) Blood Vessels (Ventfort®) Bone Marrow (Bonomarlot®) ► Cartilage (Sigumir®) ► CNS/ Brain (Cerluten®) ► Heart (Chelohart®)

► ► ► ►

SPECIALIST

► Foodsafe®

GHRPs (growth hormone releasing peptides) ► GHRP2 (GHRP2Pro™)

PEPTIDE BIOREGULATORS (bovine source, includes Nature’s Marvels™)

► Thyroids (natural, T3) ► TRH (Abaris™) ► Progesterone (ProgestPro™) ► Vasopressin (VasoPro™)

Naltrexone (NalPro™) Rapamycin (RapaPro™) Sildenafil (SildenafilPro™) Tadalafil (TadalafilPro™)

TOPICALS ► BEC5® Curaderm cream ► Can-C™ eye-drops

NUTRITION ► ► ► ► ► ►

ACF228® BloodSugarPro™ Boluoke® (lumbrokinase) BoostPro™ Can-C™ Plus DIMPro™

| 46 | Aging Matters

► DiscomfortReliefPro™ (PEA) ► EDTAPro™ (EDTA) ► EnergyPro™ (COQ10+++) ► LacticPro™ ► LongevityPro ► NAD (NMN) ► NitricPro™

► ► ► ► ► ► ►

SpermidinePro™ StressPro™ Symprove® TA65® TestoXLR8Pro™™ VigorPro™ ViralPro™

For more information visit:

www.antiaging-systems.com The World’s most comprehensive antiaging resource

Aging Matters | 47 |

SEPTEMBER 30TH OCTOBER 1ST, 2ND 2022 Luton Hoo Hotel, Golf & Spa, Bedfordshire, England

HACK YOUR HEALTH AND AGEING WITH PEPTIDES Discover how peptides adapt ageing through epigenetics and how to use them to optimize your healthspan and lifespan. An extraordinary learning seminar that features peptide experts from around the world, all presenting practical details on how to maximise healthspan and merge it with lifespan. EARLY BIRD SPECIAL

INVITED SPEAKERS:

Professor Vladimir Khavinson Professor Svetlana Trofimova Marios Kyriazis, M.D. Bill Lawrence, Ph.D. Valerio di Nicola, M.D., Ph.D. Brian Halvorsen, BDS. Thierry Hertoghe, M.D. Robert Verkerk, Ph.D.

For more information visit profound-health-summit.com or email emma@profound-health-summit.com

We welcome individuals, health professionals and business owners

Aging Matters Magazine: V3 ISSUE 40 2022, 'Cleaning up with autophagy'

Articles inside

Testimonials Professionals’ comment on IAS

Welcome To the first edition of 2022