Aging Matters, Issue 2 2019 by International Antiaging Systems (IAS)

SPECIAL EDITION 2019 (Anthology) US $10 / EU â&#x201A;Ź8 / GB ÂŁ7

The IAS private members club magazine

WTF! In this issue: Reversing cataracts

Reversing hearing loss

Reversing macular degeneration

Reversing skin cancer

TESTIMONIALS DR. AUBREY DE GREY Ph.D. “IAS has shown great vision and leadership as an organization focused mainly on the provision of contemporary medical interventions against aging, and in also supporting the SENS Foundation efforts to hasten the development of much more powerful future interventions.”

NICHOLAS PERRICONE M.D. “IAS is an outstanding resource for the finest, most up-to-date news and information on healthy aging. They also offer products of the highest integrity and efficacy. In fact, IAS is the world’s greatest source, (often the only source) for the most cutting-edge and advanced nutrients to ensure optimum health span and maximum life span.”

THIERRY HERTOGHE M.D. “IAS have a history of making throughout the world crucial, but difficult to access medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has helped this new medical speciality move forward.”

JONATHAN V. WRIGHT M.D. “Every adult has the right to take care of his or her own personal health as he or she chooses. In the 20th and 21st centuries this universal human right has been nearly obliterated by an ocean of nanny state regulations and deliberate suppression of information by bureaucracies, with hidden and not-so hidden agendas. International Antiaging Systems is a beacon of useful health care information and a literal island of freedom of health care product choice in our otherwise unfree health care world.”

DR. WALTER PIERPAOLI “I have known IAS for many years and they are a qualified group who provide for me, my family and my patients. Their skill and professional capacity has liberated me from all sorts of problems concerning the search for guaranteed and often rare supplements, or anything which is available but problematic to find. Their service goes far beyond duty and helps in many ways to maintain optimal health.”

1. Declaration: The Aging Matters™ magazine is intended for IAS private club members (and therefore is not intended for the public). It focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the main focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual. 2. Copyright 2019: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents. 3. Disclaimer: All educational information is offered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. Any prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice. Further restrictions may apply.

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CONTENTS 03

Welcome

Reversing skin cancer with a cream

To our special edition

Unbelievable, but documented facts

Reversing cataracts with eye-drops The game changer called Can-C

Reversing macular degeneration A breakthrough for wet & dry types

Reversing hearing loss with a hormone

28 FEATURED PRODUCTS 02 Testimonials & Explanations Nice comments from nice people!

38 Antiaging-Systems.com Where to find what you need

How aldosterone helps

WELCOME After all, our health is of paramount importance and if one is aware of the real choices that are available, then one can choose the most efficacious and safest choice* available.

This is our first anthology, a collection of some of the most ‘shocking’ articles we’ve published in recent years. We refer to ‘shocking’ in a nice way, meaning that when most people learn of such things, and find out that it is already possible, (in some cases having been available for many years) they usually cry out; “why doesn’t everyone know this?” Or perhaps more specifically; “why doesn’t my doctor know this?”

And by the way, if you are wondering what the cover title of WTF? means, naturally it stands for; ‘What’s The Future?’ LOL! *Referring to the Hippocratic oath of ‘first do no harm.’

We could dedicate an entire issue to answer that question, but here we want to focus your attention onto the types of breakthrough news that is published in the Aging Matters™ magazine.

Phil Micans, MS, PharmB

Editor, Aging Matters™ Magazine

First, a quick background: In 1996 the epistle began as the ‘Antiaging Bulletin’ and it was a humble black and white newsletter. A few years later it morphed into a color magazine titled; ‘International Antiaging Magazine’. Then in 2012, the revised Aging Matters™ magazine was created and it and its website have led the way ever since.

Ward Dean, M.D. Medical Director

Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members (and therefore is not intended for the public). It focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual.

So far, (as of the beginning of 2019) that’s 33 full-color issues.

Copyright 2019: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents.

Thus, we invite you to keep abreast of the latest global healthnews and you can do so by subscribing via: www.aging-matters. com for your free digital copy, (and the ability to download back issues).

Disclaimer: All educational information is offered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. Any prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice.

If you want more specific product focused information, then subscribe to the free IAS newsletter via: www.antiaging-systems.com

www.aging-matters.com

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Can-CTM - The Anti-Cataract Eye-Drop

CAN-C™ THE ANTI-CATARACT EYE-DROP It’s good news… Eye surgery is now no longer the only option available if you suffer from conditions such as cataracts, dry eye syndrome or blurred vision. Can-C™ eye-drops give the opportunity to take control of various eye conditions. Helping to turn back the hands of time on what was once thought of as just being part and parcel of growing old, but now can now be treated effectively, without the need for any invasive procedures at all. Thanks to remarkable Russian research, Can-C™ eyedrops offer a genuine alternative to surgery. Now, cataracts can be treated simply by the daily use of eye-drops. Specifically designed for the treatment of senile cataracts and using a unique, patented formula containing the active and natural ingredient N-acetylcarnosine. Can-C™ eye-drops gently but effectively can slow, halt and even reverse the progress of cataracts. And the results are evident incredibly quickly. Even after just 1 month of treatment, the effects of Can-C™ eye-drops are clearly visible - breaking down the impaired proteins in the crystalline of the lens that cause the cataracts. Cataract is the leading cause of blindness and accounts for about 42% of all such cases worldwide. More than 17 million people around the world are blind because of cataract and an alarmingly, 28,000 new cases are reported every day. Chronic, age-related visual problems such as cataract, macular degeneration and glaucoma have one basic similarity. These are degenerative conditions caused by excessive oxidation (free radical damage- free radicals are toxic by-products of your everyday metabolism). With aging, the production of these free radicals increases, whereas the body defences against them become less effective. Free radicals destroy proteins, enzymes and DNA causing chronic damage to tissues. A related process known as glycation is also strongly implicated; this process which conveniently abbreviates 4

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to AGE (advanced glycated end-products) is one where oxygen and glucose impair protein by cross-linking them. Can-C™ is the original N-acetylcarnosine (NAC) eye-drop formula. The drops have been commercially sold since 2001 and in that time has helped many thousands of people treat their senile cataracts without the need for surgery. In fact, it is estimated that there have now been more than 50,000 documented patient cases of Can-C™ use.

WITH CAN-C™, YOU GET TO KEEP YOUR NATURAL LENS Vision may be the most precious of our five senses. Yet most of us take it for granted until it begins to deteriorate with age. Many thousands of patients using the eye-drops have noticed improvements of their vision, ranging from mild improvement to complete resolution of the condition. According to the manufacturers of Can-C™ lubricant eyedrops, with over half a million bottles sold worldwide. This means that many people have retained their natural lens and not needed to have it replaced by a plastic one. It should be obvious that a plastic lens does not have the optic accommodation and capacity of a natural one.

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Can-CTM - The Anti-Cataract Eye-Drop

VISION IS PRECIOUS. PICTURES ARE WORTH A THOUSAND WORDS So many times we hear people say, “My eyes aren’t what they used to be.” The simple fact is… they most probably aren’t. But that’s life, we get older and our bodies change. However, you don’t have to sit back and give up hope for improved vision.

THE CATARACT EYE-DROP TREATMENT IS A PROVEN AND SCIENTIFIC ONE AND BASED ON CLINICAL EXPERIENCE If you are frustrated with your eyesight, ask yourself these questions: –– Are my eyes sensitive to light; or do I get cloudiness in parts of my vision? –– Which problem do I deal with first? My difficulty riving at night, the overwhelming glare or my increased near sightedness? –– When did this start happening to me? Is it stable or getting worse? –– Why is this happening to me? You could be the fittest person in the neighbourhood but your eyes may tell a different story. Everyone has their story. As we talk to customers all the time, they ask questions and we help to provide the answers. Some examples: QQ Can Can-C™ be taken in conjunction with other common eye supplements such as lutein and zeaxanthin / astaxanthin? AA We do not recommend that the Can-C™ eye-drops are combined with lutein (unless a patient has a cataract associated with a retinal disorder), this is because lutein appears to interfere with the same receptor sites as NAC and may lower the efficacy of the eye-drops. You should stop taking lutein for at least the first 6 months but after this period they may be started again. This is because Can-C™ does the majority of its restorative work in that period and thereafter it is maintenance, thus a reduced efficacy is not so essential. The same is true for zeaxanthin; however we are not aware of contraindications with astaxanthin. 6

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QQ How long has Can-C™ been available? AA Can-C has been sold since 2001 and in that time has helped thousands of people treat their senile cataracts without surgery.

QQ Are there any problems using Can-C™ concurrently with other eye-drops for glaucoma pressure control? Would you recommend use of both? AA To date, there have been no noted contraindications or side effects noted with the use of other eyedrops combined with Can-C™, but naturally, as there are so many versions, not all eye-drops have been tested along with the same. Dr. Mark Babizhayev (the inventor of the technology) has stated that beta blocker eye-drops used for glaucoma may actually have additional benefit when combined with Can-C™ to help further reduce the intraocular pressure.

LOOK TO YOUR FUTURE WITH CLEARER VISION The statistics in the human trials for Can-C™ show that N-acetylcarnosine eye-drops applied for 6-months twice daily into the eye, in patients, all suffering from senile cataract, had the following results: 1. 88.9% had an improvement in glare sensitivity. 2. 41.5% had an improvement of the transmissivity of the lens. 3. 90% had an improvement in visual acuity. Note: You can also maximise the benefit of using Can-C™ eye drops by taking Can-C™ Plus capsules. They are especially recommended in difficult cases, or for ripe cataracts (cataracts that have existed for a long time). So those who have very dense cataract and severely diminished vision to start with should combine the capsules with the eye-drops from day one.

The Can-C™ products can assist with lots of other eye conditions, such as: –– Dry eye syndrome –– Contact lens comfort (both as a lubricant and also because they block the painful accumulation of lactic acid which is caused by the contact lens rubbing onto the eye). –– Corneal disorders

Can-CTM - The Anti-Cataract Eye-Drop

–– Wound or incision leak - sometimes the corneal incision does not seal properly and may leak.

–– Computer vision syndrome –– Eye strain

–– Endophthalmitis or ‘inner eye infection’ - an infection after cataract surgery is rare but can occur.

–– Ocular inflammation –– Blurred vision

–– Rupture of the posterior capsule - during cataract surgery, the cloudy or opacified lens material is ‘chopped up’ and suctioned to remove it from the eye. Occasionally it is possible that the posterior lens capsule will tear or rupture during surgery.

–– Presbyopia –– Retinal issues –– Vitreous opacities and lesions –– Complications of diabetes mellitus and other systemic diseases

–– Retinal detachment - if you are extremely nearsighted you may be at greater risk for retinal detachment in general and especially when you have any type of eye surgery including cataract surgery.

–– Open-angle primary glaucoma

SHORT TERM CATARACT SRGERY COMPLICATIONS

–– Glaucoma - in general, secondary Glaucoma after cataract surgery is very unusual. However, if there is other bleeding or inflammation it can predispose the development of secondary Glaucoma.

Cataract surgery may be the most performed surgical procedure in the world, but it is not without its problems and complications – for example, 24 hours after surgery the following can occur:

–– Significant astigmatism - in the event that it was necessary to use sutures or stitches- because the corneal incision did not seal properly, it is possible to distort the shape of the cornea and induce astigmatism.

–– Bleeding - inside the back of the eye and inside the front of the eye where the actual surgery is being performed. –– Bruise or ‘black eye’ - if it was necessary to use an injection around your eye you may experience some temporary bruising.

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LONG TERM CATARACT SURGERY COMPLICATIONS Long term cataract surgery problems and complications are those that we will define as occurring from one week to as long as six months after cataract surgery. –– Decentered or dislocated intraocular lens implant (IOL) - the artificial lens implant (IOL) used to correct your vision after cataract surgery can move slightly becoming decentered or move a greater amount and become dislocated. –– Cystoid macular edema - during the first three months or so after cataract surgery it is possible for the macula, the visual center of the retina, to be susceptible to microscopic swelling. –– Secondary or after cataract - the most common complication of cataract surgery is opacification of the posterior lens capsule resulting in the formation of a secondary cataract, which occurs after as many as 30% of cataract surgery procedures. When this occurs you will experience a gradual blurring of your vision. Here, the surgeon uses a YAG laser to perform a procedure called a YAG laser capsulotomy in which a small opening is created in the cloudy membrane. This is just an overview of the possible complications of cataract surgery. Of course, none of the information provided here is meant to be a substitute or replace your physician’s consultation nor does it replace the need for you to consult with your surgeon about specific details of cataract surgery complications.

KNOWLEDGE IS POWER

“Life begins at 40 – but so do fallen arches, rheumatism, faulty eyesight, and the tendency to tell a story to the same person, three or four times.” Helen Rowland

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Aldosterone, The Hearing Hormone

ALDOSTERONE, THE HEARING HORMONE Improved word recognition for those with hearing loss By Dr. Richard Lippman Researchers have discovered yet another hearing breakthrough that does not involve purchasing a hearing aid! With this new treatment, those with hearing loss caused by aging can enjoy increased sound volume and more importantly, improved word recognition. As a result of their restored hearing and comprehension, those with hearing loss can become more sociable again without the need for hearing aids. Another benefit of this treatment is that those who suffer from the need to urinate frequently suddenly experience improved bladder control. A third benefit is the eradication of the type of dizzy spells that occur when a patient stands up quickly after sitting for a long period of time. Patients enjoy all these benefits when they use eardrops that employ a special time-releasing mechanism for the hormone aldosterone. The eardrops are used in the morning so that the advanced time-release technology can release the natural hormone aldosterone slowly and evenly throughout the day in proximity to the cochlea, the hearing center of the ear. I have heard from numerous patients who are thrilled that these eardrops have allowed them to resume their formerly active social lives.

MY EXPERIENCES WITH ALDOSTERONE AND HEARING LOSS During the last thirty years, I have made many medical discoveries (including the nicotine patch) that have saved the lives of millions of people. I have also noticed that hormone deficiencies due to aging caused needless suffering in millions of people. This led me to the conclusion that the loss of hormones through shrinking endocrine glands can cause hearing loss and numerous other illnesses encountered during aging. One key hormone that declines with age is aldosterone. I have found that patients with hearing loss were temporarily 10

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helped by consuming aldosterone 125 mcg capsules two to five times daily. However, this effect was only temporary because natural aldosterone is metabolized quickly and excreted from the body. This meant that taking a large quantity of capsules throughout the day was necessary because aldosterone has a short metabolic half-life. I believed that there had to be a better way to administer aldosterone and in 2011, I devised my Lippman Protocol, in which patients improved their hearing by taking natural aldosterone capsules some days and synthetic aldosterone (FlorinefÂŽ) other days. For many patients, this protocol simplified the need to take hearing meds, but I was still dissatisfied. Then, in 2014, I devised yet another method of improving hearing by employing the latest in time-release technology. I applied this new, cutting-edge technology to the natural hormone aldosterone and discovered, much to my amazement, that word recognition, tinnitus and decreased bathroom visits were the additional fruits of my research!

Aldosterone, The Hearing Hormone

HISTORY OF ATTEMPTS TO IMPROVE HEARING

“Apparently, the synthetic aldosterone drug, Florinef® (fludrocortisone) acts only on some inner-ear hair cell receptor sites while bioidentical (natural) aldosterone acts on all sites. Sound volume increases but there is not necessarily better word discrimination. This duel receptor-site action triggers an 85 millivolts threshold of electrical conductivity through the nerves of the inner ear. This trigger also depends upon a balanced electrolyte ratio of potassium and sodium. Thus, this combined hormone and electrolyte action produces significant sound-volume hearing improvement, but rather marginal improvement in word recognition since only two of the five rows control word recognition and they are only marginally activated (4).”

More than a decade ago in Rochester, New York, scientists correlated hearing loss with decreased blood levels of aldosterone. They discovered that the more aldosterone present within the bloodstream, the better the hearing. The National Institute on Aging (NIA) verified this important research (1, 2, 3 and 5). Interestingly, people with hearing loss have, on average, less than half as much aldosterone in their blood as those with normal hearing. I’ve seen relatives of mine with hearing loss have one fourth to one sixth as much aldosterone as those with normal hearing.

ACTIVATING ROWS OF HAIR CELLS THAT TRANSMIT SOUND TO THE BRAIN The inner ear contains approximately 15,000 hair cells that vibrate to sound. They are divided into five rows and aldosterone appears to impact them. Aldosterone and fludrocortisone trigger pure-tone hearing thresholds by activating these five rows of hair cells in both ears. The result is increased sound volume in both the human voice and interfering background noises. However, word recognition is only partially remedied. In my lectures in Sweden, I made the following statement on this subject:

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Aldosterone, The Hearing Hormone

Then in 2008, other researchers at the University of Portland in Oregon discovered that there was a reversal in hearing loss with aldosterone by increasing sodium transport in mice. Apparently, the natural hormone aldosterone increases sodium versus potassium in the nerve endings in the cochlea (inner ear). Indeed, researchers verified that the physiology of inner and middle ear improves somewhat with aldosterone (5). However, the synthetic version of aldosterone, fludrocortisone, seems to attach so completely to the aldosterone receptor sites that it prevents natural aldosterone from fully activating its own receptors. Eminent Harvard graduate and antiaging specialist, Dr. Jonathan Wright, of the Tahoma Clinic in Renton, Washington found that one patient with Meniere’s disease improved his hearing by 30 decibels at 250 Hz when 125 micrograms of bioidentical (natural) aldosterone were consumed twice daily for seven months (4). I confirmed these results by improving patients’ hearing by more than 30 decibels at 3,000 Hz with my special protocol. This latter result is especially important since 3,000 Hz falls squarely inside the human vocal range. At this approximate 3,000 Hz vocal level, patients’ hearing could be improved by as much as 40 decibels, but only after several months of applying my 2011 Lippman Protocol. There was a problem, however, that was that word recognition was impaired and sometimes non-existent and difficulties with tinnitus continued.

POSSIBLE SIDE EFFECTS Regarding adverse effects, Dr. Wright has stated: “None of the people I’ve worked with have had any adverse effects from aldosterone therapy, likely because the use of bioidentical, physiologic-dose aldosterone restores levels to those that would be found in the body anyway” (4). In my research, I found that not everyone wants a 40-decibel enhancement. Such an enhancement can typically cause street noises to become too loud and even necessitate wearing earplugs at movie theaters. At times, due to this therapy, patients are forced to cover their ears tightly when an emergency vehicle drove by. In addition, I found that greatly enhanced hearing necessitates remembering to raise one’s voice during a conversation in order to be clearly heard by those with normal hearing. Dr. Wright and I confirmed that hearing volume improved dramatically when taking aldosterone and that forgetting to take it resulted in an unfortunate and dramatic return to hearing deficiency, tinnitus, and possible social isolation. We tested urine levels of aldosterone and confirmed that very low scores of below 5 micrograms per 24 hours were found in hearing deficient patients compared to scores of 20 to 30 micrograms per

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Aldosterone, The Hearing Hormone

24 hours in people with normal hearing. In fact, Dr. Wright’s 84-year-old patient consumed natural aldosterone capsules and increased his sound volume from 23 to 91 percent in his right ear and from 3 to 81 percent in his left ear (4).

HOW DO HORMONES AND NUTRIENTS IMPACT HEARING? Low aldosterone is often seen as a biomarker for aging. Aging causes imbalances in the circadian rhythm (sleep cycle), which often result in the adrenal glands producing more and more of the stress hormone cortisol and less and less of other critical hormones such as aldosterone and DHEA, (an anabolic hormone that builds new tissues). The excess cortisol causes insomnia and unnecessary destruction of the body’s tissues (catabolic), while simultaneously decreasing aldosterone and causing hearing loss, frequent urination and declining DHEA. Low aldosterone may also lead to symptoms such as dizziness, low blood pressure, thirst, dehydration, and salt cravings. Many of these symptoms result in imbalances in the potassium /sodium ratio that leads to fatigue and cellular energy loss in the inner ear’s 15,000 hair cells. Externally, signs of significant dehydration can be seen in people with fine lines, pinched faces, sinuous necks and a profound daily need for cosmetic lotions that superficially moisten their skin (6). Thus, a billion dollar cosmetic industry continues to sell their moisturizing and anti-wrinkle creams while the underlying medical problems, namely low hormone levels, remain untreated. In addition to low aldosterone and an imbalance in potassium and sodium, other vital nutrients may be lacking. Vitamins B12 (methylcobalamin preferred), folate (methylfolate – NOT folic acid) and oxytocin are nutrients essential to normal hearing. Interestingly, hearing loss may sometimes be reversed if 5,000 units of vitamin D3 are taken as a daily supplement. Note: Some prescription drugs such as Aldactone® (spironolactone) can impair hearing. (7)

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Aldosterone, The Hearing Hormone

On the fourth day, repeat the cycle, starting with again with fludrocortisone. This regimen will ensure constant high-decibel enhancement, except during sleeping hours, in which reduced hearing and increased tinnitus recur. For greater absorption into the bloodstream, I recommend drinking grapefruit juice with the aldosterone capsules. But do not use grapefruit juice with fludrocortisone (or for that matter any other prescription drug). Also, notice that only tiny, judicious microgram doses of aldosterone and fludrocortisone are employed. According to Europe’s foremost endocrinologist, Thierry Hertoghe, MD, use only the smallest, most judicious dose possible for efficacy. More is not better when it comes to all hormones and nutriceuticals. Mega dosing is a mistake. This advice helps to prevent the serious side effects often seen when hormones and nutriceuticals are used excessively. Do not mega dose! For example, 100 micrograms of fludrocortisone can cause sleepiness and lethargy.

CURRENT HEARING ENHANCEMENT RESEARCH Much to the astonishment of my colleagues, I discovered that a patient should consume only one 125 mcg capsule of natural aldosterone daily and that it should be taken in the morning on an empty stomach. For those over the age of 50 who often have impaired stomach absorption, I recommend drinking 4 ounces of grapefruit juice with the capsule. My natural aldosterone therapy improves hearing volume by more than 30 decibels when continued for several months. This decibel quantity is huge: 30 decibels-plus means the difference between deafness and fairly normal hearing. For example, after following the Lippman Protocol for about a month, the hearing-impaired are able to carry on a conversation at a loud party with high volume background music. Sufficient hearing at loud parties becomes possible despite having consumed only a single capsule 15 hours earlier in the day.

THE LIPPMAN ONE-CAPSULE-DAILY PROTOCOL FOR INCREASED VOLUME ONLY On the morning of day one of the Lippman Protocol, take 20 micrograms of fludrocortisone with filtered water. Over the next two days, take one capsule of 125 micrograms of aldosterone daily before breakfast. 14

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On the other hand, in patients who have difficulties with word recognition, I recommend the all new aldosterone product, Aldo-Pro™ eardrops, which slowly time-releases aldosterone, thus allowing for improved word recognition.

ALDO-PRO™ USE IMPROVES SOUND VOLUME AND WORD RECOGNITION Aldo-Pro™ is easy to use. Upon waking, simply tilt your head to each side and press the plunger on the applicator bottle to enable a single dose of Aldo-Pro™ to enter each ear canal. Wipe off excess fluid with a paper towel. Most people will notice some hearing improvement after about one hour; a hearing improvement of approximately 30 decibels to 40 decibels occurs two to three hours after application. In some people, both hearing and word recognition continue to improve throughout the day. In addition, tinnitus subsides throughout the day but returns at night, when aldosterone in the body returns to a deficient level. Before bedtime, you should gently clean your ear canals by using a cotton swab or by washing them out with soap and water.

Aldosterone, The Hearing Hormone

TREATMENT OF THE EAR CANALS BEFORE USE Before using Aldo-Pro™, be sure to check with your hearing specialist to determine that you don’t have a fungal growth in your ear canals. A typical symptom of fungal growth is itchiness in the ear. Ear canal fungal growth may be treated with a synthetic antifungal medication like Nystatin©. However, I’d strongly recommend using a completely natural solution called Pro-Ear™ that is available from several online retailers.

OLD HABITS ARE HARD TO BREAK Recently, two physician friends were skeptical and feared changing their old habit of recommending only hearing aids to their patients. They asked me why I bothered with a bunch of capsules or ear drops. “Why not just buy a hearing aid?” one ear, nose, and throat doctor asked me. I answered him with a question: “What makes better medical sense: taking one capsule or ear drops daily and correcting a hormone deficiency or amplifying the volume on an already damaged hearing system?” My question flummoxed and silenced both of them. We should be enjoying our golden years without highvolume hearing aids distorting already damaged hearing systems. You decide. One capsule/ or some ear drops a day works!

References 1. 2.

Tadros, SF et al, Nov. 2005. A Possible Protective Hormone against Presbycusic. Hearing

Otolaryngology Head Neck Surgery, Nov. 2008.

Research, 209 (1-2), pp. 10-18.

Hertoghe, T. May, 2010, Picture Atlas of Endocrinology & Hormone Therapy, SA International

Trune, DR and Kempton, JB, May 2001, Aldosterone and Prednisone Control of

Medical Books, Windhof, Luxembourg.

Cochlear Function in MRL, MpJ-Fas (1pr) Autoimmune Mouse Ear. Hearing Research, 1

55 (1-2), pp. 9-20 3.

Laryngoscope, Feb. 2002.

Trune, DR et al, Feb. 2006. Mineralocorticoid Receptor Mediates Glucocorticoid Treatments Effects In The Autoimmune Mouse Ear. Hearing Research, 212 (1-2), pp.22-32.

Wright, JV. Oct. 2008, Don’t Go Deaf, Blind, or Lose Your Mind! Nutrition & Hearing, Vol. 15, Issue 8, pp. 1-7.

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The treatment of choice for non-melanoma skin cancers

THE TREATMENT OF CHOICE FOR NON-MELANOMA SKIN CANCERS By Bill E. Cham, Ph.D. to the public for the treatment of cutaneous solar keratosis, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This communication gives us some insight how, on the one hand, nature through one of its major forces- sun light, is causing increasingly higher incidences of human skin cancers but, on the other hand, nature, also with the involvement of sunlight and plants has supplied the solution on how to eradicate these skin cancers. The etiologies of keratosis, BCC and SCC, their currently available treatments, and the particular attributes of BEC5-Curaderm within these concepts of pathogenesis and therapeutics, are presented in this article.

KERATOSIS The laws of nature may be considered as; “the forces and processes that produce and control all the phenomena of the material world.” The sun is a major force in nature and is essential for life on earth; unfortunately, the sun also produces some unwanted side-effects for humans. It is fashionable to have a suntan and people feel that exposing their skin to the sun is a healthy, pleasant thing to do. However, the sun also has a “dark side” in that, the ultraviolet part of the electromagnetic spectrum produced by the sun as light, in-particular U.V.-B (290320nm), is responsible for producing long-term solar skin damage (keratosis) and skin cancers. In fact, skin cancers are the most common malignancy in humans. BEC5-Curaderm is a topical cream preparation of a mixture of the glycoalkaloids solasodine glycosides (BEC). BECs are present in some solanaceous plants, including edible plants such as Solanum melongena (otherwise known as eggplant or aubergine). Now, BEC is available 16

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An overgrowth of the epidermis forms a scaly layer on the skin. The start of this lesion is usually a small patch of dilated capillaries several millimetres in diameter. Then a dry, rough, adherent yellow or dirty brown scale forms, which may bleed if picked off. It may eventually become thick and horny, with a sharp, clear division between the keratosis and normal skin. Solar keratoses occasionally regress if sun exposure is stopped before they become too established. Although non-malignant, they are potentially malignant and can develop into cancer.

BASAL CELL CARCINOMA (BCC) A BCC is a malignant tumour that rarely spreads to distant sites (metastasises). It starts in the basal layer of cells, between the basement membrane and the subsequent layer of cells and grows upwards from these. It consists of immature cells and has an organized complex of supportive tissue around it. The primary cause of BCC is sunlight exposed onto sensitive skin. Contributory causes are radiation damage, exposure to arsenic, burn scars and vaccination marks.

BCCs are the most common malignant skin tumours in humans; they do not spread by metastases, but they erode tissue, and if not treated it may eventually kill. BCCs may appear in a variety of guises and on first appearance; they are commonly small, rounded lumps with a pearly edge, and a thin surface covering with a few superficial transparent blood vessels. BCCs may also appear as ulcers, or as bleeding or non-healing lesions. Occasionally they appear as flat diffuse crusting or scaling red lesions. BCC tumours usually grow slowly but in a relentless manner. They then ulcerate and the ulcer will follow the spreading tumour, causing further damage, (for this reason they are also known as rodent ulcers).

SQUAMOUS CELL CARCINOMA (SCC) An SCC is a malignant tumour arising from the cells above the basal layer of the epidermis (prickle layer), usually after many years of exposure to sunlight. The cells in the prickle layer are maturing towards keratin formation and the cancer occurs when they accelerate in growth and breakthrough the basement membrane into the dermis. Although sunlight is the most common cause of SCC, any cancer-producing substance (carcinogen) may initiate its development. SCCs often arise from precancerous conditions such as solar keratoses. SCCs may also develop from skin ulcers, scar tissues, and x-ray damaged tissues, if this occurs then the chance of metastasis increases to approximately 20%. In addition, some 40% of transplant patients who are on immunosuppressive drugs develop SCCs within 5-years post-transplantation. This skin cancer is a serious problem and is potentially deadly. The first sign of an SCC is usually a thickening, with the lesion feeling firm, and the limits are not discrete. In the early stages there may be a crust that may later shed to show an ulcer. It may also form as a crack (fissure) or a small ulcer on the lip, which fails to heal and bleeds recurrently. The SCC may metastasise with an incidence of generally less than 5%. AGINGMATTERS 17

The treatment of choice for non-melanoma skin cancers

OLD ESTABLISHED TREATMENTS SURGERY There are various surgical techniques available to treat skin cancer in its various forms. Surgical excision of a tumour has the advantage that if done correctly, removes the affected area virtually completely. This treatment is extensive, requires anaesthesia and depending on the tumour, may require skin grafting with its accompanying cosmetic limitations. The risks of surgical intervention are well known and excision of BCCs or SCCs from the facial area often involves reconstructive surgery, which can be both time consuming and costly.

RADIOTHERAPY Radiotherapy, moreover prior to the 1950â&#x20AC;&#x2122;s than now, has been used to treat most skin cancers. The disadvantage of this mode of treatment is the resulting scar tissue which may be depressed, depigmented and may also undergo degenerative and malignant changes at a later date.

DERMATOLOGICAL Dermatological treatment consists of curettage and diathermy/ cauterisation, cryotherapy, chemosurgery and chemotherapy, and is generally used for superficial skin cancers. With curettage and diathermy, the tumour is scraped out and the bleeding stopped by cauterisation, (application of heat) by an electric current (diathermy). Cryotherapy, possibly the most widely used method, involves an intensely cold probe, cooled by liquid nitrogen, which is applied to the lesion. When the lesion thaws, there is pain in the treated area, followed by blister formation. Chemosurgery involves chemical fixation of the lesion and the fixed tissue is shaved off in layers. Chemotherapy with 5-fluorouracil (5-FU), which is an anti-metabolite and inhibits RNA and protein syntheses leading to cell death, is used to treat superficial lesions, but it is not specific for cancer cells. 5-FU is supplied as an ointment and requires considerable care in its application under medical supervision.

AGINGMATTERS

The treatment of choice for non-melanoma skin cancers

Specific endogenous lectins (EELS), which are specific receptors for the sugar part of the glycoalkaloids and are present in the plasma membranes of susceptible cancer cells but not normal cells recognize and bind the sugar rhamnose of the BEC glycoalkaloids. BEC subsequently enters the cancer cell and causes cell death by destroying the lysosome (6, 13-17).

All these methods (surgery, radiotherapy and dermatological) have their own individual limitations. However, the limitations common to all of these methods are: –– Formation of scar tissue –– Lack of normal tissue regrowth –– Limited access to the lesion if it is deep within the skin

BEC has been shown to have antineoplastic activity in cell culture, animals and in humans (1, 3-12). Currently Phase II studies with BEC are being carried out on terminal internal tumours in man. With these studies BEC in being administered intravenously (18).

–– A high rate of recurrence –– Cosmetic end-result

NEW SPECIFIC TREATMENTS It is now well established that specific glycoalkaloids from the Solanum family have anticancer properties. The specific glycoalkaloids consist of BEC, which is a standardised mixture of triglycosides, solasonine and solamargine and their corresponding di- and mono-glycosides (1-12). All the glycosides contain the same aglycone, (the alkaloid without a sugar molecule)- solasodine.

PRECURSOR OF BEC5-CURADERM A cream formulation of BEC in concentrations of up to 10% was well tolerated in an open tolerance and dose-finding Phase I and II studies in healthy volunteers and in patients with actinic keratosis, BCC and SCC (3). Application of the cream in this study resulted in swelling of the BCC and SCC lesions, with erythema (reddening) of the surrounding skin, then ulceration in about 2 days, followed over the next weeks by healing with healthy new cell growth. The only reported adverse events were mild itching and burning sensations at the site of the lesions in a few patients.

Solasodine on its own does not have anticancer properties; however, the mono-, di- and triglycosides do have anticancer properties. These glycosides contain a plant sugar rhamnose, which is not usually found in mammalian species.

Before:

After:

AGINGMATTERS 19

The treatment of choice for non-melanoma skin cancers

Curaderm are very impressive and over 80,000 patients have now used BEC5-Curaderm successfully.

BRITISH CLINICAL TRIALS WITH BEC5-CURADERM A double-blind, vehicle-controlled (placebo), randomised, parallel group study of 94 patients was carried out to assess the efficacy and safety of BEC5-Curaderm in the treatment of patients with BCC. This was a multi-centre Phase III study involving 10 centres in the United Kingdom. The centres were as follows:

BEC5-CURADERM

–– University of Wales College of Medicine

In another open study with 72 patients, their treatment with a cream formulation of BEC 0.005% called BEC5Curaderm, resulted in the regression of all treated lesions (56 actinic keratoses, 39 BCCs and 29 SCCs), with 100% healed after 1 to 13 weeks of treatment (9). There were no lasting therapeutic effects in the 14 patients who received placebo.

–– Leicester Royal Infirmary

It is important to note that BEC5-Curaderm contained extremely low concentrations of BEC (0.005%). One tube of Curaderm containing 20g of cream formulation contained the equivalent of BEC as 5g of eggplant fruit (19). However, for BEC to be effective it must first be purified from its source by a specific process. Unlike other extracts used for therapeutic effects, in which the active ingredients have to be concentrated, with BEC5Curaderm the active ingredients in the plant material have to be diluted to still obtain the anticancer effects. In other words, the active glycoalkaloid ingredients are extremely safe as BEC5-Curaderm contains less glycoalkaloid than the edible eggplant fruit! In the book “the eggplant cancer cure” published by Smart Publications there are many illustrations that show various clinical and histological malignant lesions before, during and after BEC5-Curaderm therapy. BEC5-Curaderm is applied at least twice daily to the skin and may be applied much more frequently if rapid regression of the tumour is required. Some patients apply the BEC5-Curaderm cream up to 10 times daily. The cosmetic results after using BEC5 20

AGINGMATTERS

–– The Royal London Hospital –– St. Mary’s Hospital –– St. Thomas’ Hospital –– Royal Free Hospital –– Singleton Hospital –– Royal Liverpool Hospital –– Derriford Hospital –– Hope Hospital The objectives of the study were to evaluate the efficacy and safety of BEC5-Curaderm in the treatment of BCCs. The primary endpoint was defined as the complete healing of the index lesions, as confirmed by the absence of tumour- determined by clinical and histological examination after 8 weeks of twice daily treatments with BEC5-Curaderm or placebo. The secondary endpoints were cosmetic evaluation, physician’s global evaluation of response to treatment, assessment of local irritation, reduction in size of the lesion and assessment of the frequency, nature and severity of adverse events. The success rate, (complete remission of skin cancers) of the BEC5-Curaderm cream was 78% within 8-weeks. Longer than the 8 weeks duration therapy with Curaderm-BEC would have resulted in even higher success rates. These results were comparable to those previously obtained and published (4, 5, 13, 14).

The treatment of choice for non-melanoma skin cancers

Over 7,000 of the commonly prescribed drugs in the western world are derived from plants. Indeed, the plant kingdom has supplied us with some excellent drugs. Pain sufferers appreciate the relief provided by morphine. Victims of congestive heart failure appreciate the life-saving role of digitoxin or digoxin. Migraine patients experience the dramatic relief affected by ergotamine. Children with leukaemia have recognized the improvement of their condition by treatment with vincristine.

Not only was it shown that BEC5-Curaderm was effective in treating superficial BCC, but in a subsequent open study trial comprising 41 patients (carried out at the Dermatology Department at the Royal London Hospital), it was also shown that BEC5-Curaderm was effective on morpheoic BCC lesions, which are a type of invasive BCC. The clinical trial experience has shown that BEC5Curaderm is safe. Only local skin irritation, some pain and erythema (reddening) occurred during treatment. Success was defined as zero presence of BCC after histological (microscopic) examination of samples, removed from the lesion sites by punch biopsy.

Importantly, in addition, the natural plant drugs have served as useful prototypes for even better medicines. Synthetic chemists have been able to convert morphine to hydro-morphone, lysergic acid to methylsergide, cocaine to procaine, physostigmine to neostigmine and even salicin to aspirin.

The conclusion of the dermatologists at the Royal London Hospital is that; “BEC5-Curaderm is a topical preparation, which is safe and effective and an ideal therapy for outpatient treatment.” They stated further that; “BEC5-Curaderm is a much-needed alternative to surgery for BCC. This is the most common cancer in Caucasians worldwide and the prevalence continues to increase with an increasing ageing population.” The conclusion of these investigations was that; “BEC5Curaderm is a cost-effective treatment for both primary and secondary skin cancer care.”

The fact that BEC shows such tremendous promise for treating internal cancers and the fact that BEC5Curaderm is now regarded as the method of choice for treating skin cancers lead us to conclude that BEC5-Curaderm is a primary candidate to be added to the acceptable list of commonly prescribed drugs. Whether synthetic chemists will be able to classify BEC as a useful prototype for terminal internal cancers remains to be seen.

These Phase III and open studies confirm the previously published articles that; BEC5-Curaderm is the method of choice for treating non-melanoma skin cancers (4, 5, 13, 14).

Before:

After:

AGINGMATTERS 21

The treatment of choice for non-melanoma skin cancers

CONCLUSIONS –– The naturally occurring glycoalkaloids solasodine glycosides (BEC) have anticancer activity in cell culture, animals and in humans. Specific endogenous lectins which are present in the plasma membranes of cancer cells recognize and bind the sugar moiety of BEC. BEC is subsequently internalised and causes cell death by destroying the lysosome. This mode of action is very different than with other anticancer drugs (which are non-specific, destroying normal cells as well) and work on the nuclear contents such as the DNA or RNA of cells.

–– The cosmetic result of skin cancer treatment with BEC5-Curaderm is excellent. –– Lesions treated appropriately with BEC5-Curaderm result in no recurrence. –– The amount of BEC in Curaderm is very small. One average-sized egg plant fruit (300g) contains the same amount of BEC as 60 tubes of Curaderm! Thus, Curaderm-BEC is safe as shown by the many published studies. –– BEC5-Curaderm is an ideal therapy for skin cancers.

–– Independent centres show that BEC5-Curaderm is virtually 100% effective for treating skin cancers if the lesions are treated for long enough.

References 1.

Cham BE, Gilliver M and Wilson L. Antitumour effects of glycoalkaloids isolated from

incanum Chinese herb triggers gene expression of human TNFR1 which may lead to cell aptosis. Biochemistry Biophysics Research Communication 1996; 229: 1-5. 15.

Cham BE. Monograph on BEC. Drugs of the Future 1988; 13: 714-716.

Cham BE and Daunter B. Curaderm (anti-neoplastic) launched in Australia. Drug News Perspectives 1989; 2: 112.

human hepatoma cells. Biochemistry Pharmacology 2000; 60: 1865-1973.

Cham BE and Daunter B. Solasodine glycosides. Selective cytotoxicity for cancer cells and inhibition of cytotoxicity by rhamnose in mice with Sarcoma 180 activity. Cancer Letters 1990; 55: 221-225.

Cham BE and Daunter B. Topical treatment of pre-malignant and malignant skin cancers with Curaderm. Drugs of Today 1990; 26: 55-58.

Cham BE, Daunter B, Evans RA. Topical treatment of malignant and premalignant skin lesions by very low concentrations of a standard mixture (BEC) of solasodine glycosides. Cancer Letters 1991; 59: 183-192.

10.

Cham BE. Solasodine glycosides: a new modality for cancer. In: Walker, MS, ed. Proceedings of the third Oceania Symposium on complementary medicine. Queensland: Bio Concepts Publishing 1992; 30-36.

11.

Cham BE. The efficacy and mode of action of solasodine glycosides (BEC) on cancer cells. In: Walker MS, ed. Proceedings of the fourth Oceania Symposium on complimentary medicine. Queensland: Bio Concepts Publishing 1993; 41-51.

12.

Cham BE. Solasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies. Asia Pacific Journal of Pharmacology 1994; 9: 113-118.

13.

Chang LC, Tsai TR, Wang JJ, Lin CN and Kuo KW. The rhamnose moiety of solamargine plays a crucial role in triggering cell death by aptosis. Biochemistry Biophysics Research Communication 1998; 242: 21-25.

16.

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Nakamura T, Komori C, Lee Y, Hashimoto F, Yahara S, Nohara T and Ejina A. Cytotoxic activities of Solanum steroidal glycosides. Biology Biopharmacy Bulletins 1996; 19: 564-566.

17.

Roddick JG, Weissenberg M and Leonard AL. Membrane disruption and enzyme inhibition of naturally-occurring and modified chaco-triose-containing Solanum steroidal

Daunter B and Cham BE. Solasodine glycosides. In vitro preferential cytotoxicity for human cancer cells. Cancer Letters 1990; 55: 209-220.

Kuo KW, Hsu SH, Li YP, Lin WL, Chang LC, Lin CC, Lin CN and Sheu HM. Anticancer activity evaluation of the Solanum glycoalkaloid solamargine. Triggering aptosis in

Cham BE and Meares HM. Glycoalkaloids from Solanum sodomaeum are effective in the treatment of skin cancers in man. Cancer Letters 1987; 36: 111-118.

Hsu SH, Tsai TR, Lin CN, Yen MH and Kuo KW. Solamargine purified from Solanum

Cham BE and Wilson L. HPLC of glycoalkaloids from Solanum sodomaeum. Planta Medica 1987; 53: 59-62.

14.

Solanum sodomaeum. Planta Medica 1987; 53: 34-36.

glycoalkaloids. Phytochemistry 2001; 56: 603-610. 18.

Solbec Pharamaceuticals Limited, Australia. www.solbec.com.au

19.

Jones PG and Fenwick GR. The glycoalkaloid content of some edible Solanaceous fruits and potato products. Journal of Science and Food Agriculture 1981; 32: 419-421.

AGINGMATTERS 23

ARMD & MZS™

ARMD & MZS™ Age-related macular degeneration and melatonin By Phil Micans, MS, PharmB Age-related macular degeneration (ARMD) is the leading cause of severe visual loss in older people, indeed it is the main cause of central vision loss (blindness) in the USA today for those over the age of fifty; (Source: American Academy of Ophthalmology). Macular degeneration is a condition whereby the light sensing cells in the eye’s macula malfunction and eventually they cease to work. Often individuals with macular degeneration will notice that straight lines, such as poles, walls or wires appear to be wavy; other symptoms can include blurred text, often with dark or even empty spaces that may block the center of the field of vision. Fortunately, macular degeneration rarely results in complete blindness since side vision is usually unaffected, but even so because of its propensity, it has been estimated that more than a million people worldwide are completely blind because of advanced ARMD! ARMD makes activities that require sharp vision such as reading or driving very difficult. A test to determine the presence of ARMD uses something called an Asmler grid. This involves starring at a center dot to see if the lines around it are affected by blurriness, waviness or even are out of vision altogether. Left: An Asmler grid as seen by a person with 4 normal vision. Right: The same grid viewed by a person with ARMD.

ARMD BACKGROUND It is not clear how or why ARMD is triggered, although the focus has been on the hardening of arteries that supply the retina at the back of the eye. Over time this deprives the tissues of oxygen and other nutrients that help it to protect itself and to thrive, the consequence of which is a gradual deterioration of vision. The central part of the retina contains a yellow pigment called macular pigment, this helps to protect the receptors in the retina from sunlight, especially from the harmful effects of blue light. The lessening of the density of this protective pigment can be linked to poor diet and in those who smoke, thus its protection from free radical damage and its enrichment are also seen as a key to ARMD.

PHYSICIANS CLASSIFY ARMD INTO TWO PARTS, NAMELY WET AND DRY The wet form affects about 15% of patients with ARMD. This form differs from the dry type in that there is a growth of abnormal blood vessels under the retina. This can lead to bleeding and scarring and results in a more rapid and severe progression of the disease, (when compared to the dry form). Luckily for about 70% of patients with the wet form of ARMD they can be treated with laser photocoagulation to help stabilize the vision, or to limit the growth of further abnormal blood vessels. But whilst the dry form affects 85% of patients with ARMD and thankfully is less progressive and not as severe as the wet form, unfortunately to-date there have been no successfully reported treatments regarding the reversal of this condition. Presently, most treatments for all ARMD’s have relied heavily upon supplementing with nutritional elements, particularly lutein and zeaxanthin to alleviate, slow down and sometimes halt its progression.

AGINGMATTERS

ARMD & MZS™

A BREAKTHROUGH FOR ARMD The study; (Changxian Yi et al, effects of melatonin in age-related macular degeneration, Ann NY Acad Sci, 1057:384-392) gives hope to millions with ARMD. Dr. Changxian Yi studied 100 patients over a period of 2-years to see if treatment with tablets of MZS™ (so called because it also contains zinc and selenium in addition to melatonin), could help the condition of ARMD.

Figure 1: The left slide shows the eye of a 67-year old male before treatment; his vision had been deteriorating for 2-years. The right picture shows the same eye 2-months later after daily ingestion of 3mg MZS™ tablets. He now has stable visual acuity of 0.3 with remarkable improvements in sub-retinal macular hemorrhage.

His thinking was that melatonin could have the capacity to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors. The unique combination in the tablets could also scavenge hydroxyradicals and help to protect retinal pigment epithelium cells from oxidative/ free radical damage- knowing that this damage is also considered to be a cause for the initiation of ARMD. As Dr. Changxian stated; “Our purpose was to explore a new approach to prevent or treat ARMD.” The approach was very simple; firstly, the patients were diagnosed with ARMD, with both the wet and dry forms included. Then 3 mg of MZS™ were given orally each night at bedtime for a minimum of 3 months, with 55 patients continuing for more than 6 months and some onto 12 and 24 months. The patients were then evaluated at regular periods to measure the extent of their ARMD.

Figure 2: The left slide shows the eye of a 71-year old female with ARMD who after 6-months of 3mg MZS™ daily her vision had improved from 0.2 to 0.4 (as indicated in the right slide).

The study reported that at 2-3 months of treatment the visual acuity had been kept stable, (in other words there appeared to be a halting of the progression of ARMD in general). It is worth noting that although this follow up time is not long; this result is already better than the otherwise normal course that could be expected. For the patients who continued onward past 6 months and onto 12 months of nightly use of 3mg MZS™ the change in their fundus pictures were remarkable, (please note the before and after eye pictures presented within this article in figures 1-3).

Figure 3: A 58-year old male whose visual acuity at the start (left slide) was 0.2. This improved to 0.4 after 6-months of regular use of MZS™. The sub-retinal hemorrhage and exudate was remarkably absorbed.

AGINGMATTERS 25

ARMD & MZS™

than this. Our research with MZS™ has highlighted its ability to re-synchronize the endocrine system as well as the circadian rhythms of the wake-sleep cycles. I note that whilst the authors of the ARMD study have discussed the role of melatonin in the eye as being able to control eye pigmentation, to help regulate the amount of light reaching the photoreceptors and other functions in relation to eye structure as possible factors in the benefits for ARMD; I also surmise that through the rebalancing of hormones and improvement of repair functions- through better sleep patterns- that these have also had this significant and profound ability to reverse this condition.” Dr. Pierpaoli went on to say; “We’ve seen many miraculous reversals of diseases in our patients with MZS™, this latest study showing that it can halt and even reverse age-related macular degeneration is another important highlight of the power of MZS™.”

At the end of the study, of the original 110 eyes tested only 8 eyes showed more retinal bleeding and 6 eyes more retinal exudates, the clear majority had dramatically reduced pathologic macular changes. This was made self-evident by the patients themselves reporting better vision and general ocular experience with improvements to flare, dryness, clarity and comfort. Whilst the authors called for larger studies to confirm their findings, they concluded that; “melatonin supplementation among the aged population may be beneficial in preventing, relieving or reducing the severity of ARMD, which is one of the leading causes of blindness in the elderly.” What’s more during the entire period (with some patients taking the 3mg tablets every night for 2-years) no significant side effects were observed.

DR. PIERPAOLI’S VIEWS We spoke with world melatonin expert Walter Pierpaoli, M.D., author of the best seller; ‘the melatonin miracle’ about this finding, he told us; “Many people are aware of melatonin’s role in jet-lag, or as a potent antioxidant, but we know it is far more 26

AGINGMATTERS

In the past Dr. Pierpaoli has gone on record to say that melatonin is a unique molecule, going as far as to announce that; “In my opinion melatonin is one of those molecules that existed before life began and that it has been put to a special use.” Asked whether there may be further studies regarding ARMD and melatonin, Dr. Pierpaoli said; “We accept that additional studies are needed to confirm these results and its mechanism, however we are delighted that a vital benefit to slow, halt and even reverse ARMD has been discovered. Whatever the outcome of further research into the pathways and actions of the MZS™, the fact remains that thousands, even millions of people can now benefit from this research to protect their vision.” As one of the world’s leading antiaging researchers, Dr. Pierpaoli has been exposing the benefits of his own and others work with melatonin, particularly at the unique Stromboli conferences in Italy. When asked for a final comment on the ARMD findings Dr. Pierpaoli said; “Here is yet another clinical study, this time about age-related macular degeneration, that can be added to the long list of disorders that include cancer, Alzheimer’s, cardiovascular, depression and even aging itself, all of which can be successfully ameliorated with MZS™.”

AGINGMATTERS 27

SPOTLIGHT

1ST LINE™ - THE FIRST LINE OF IMMUNITY Professor Paul Clayton reported in the Aging Matters magazine No1, 2012, that ‘the age of antibiotics is coming to an end.’ This has been a concern for some time as antibiotics becomes less effective and can’t be relied upon as they were in the past. What’s more, antibiotics do not destroy viruses, and when it comes to effective antivirals there are very few choices indeed. OSCN A British chemist by the name of Richard Steed was concerned how chlorine was being in food- as it is sprayed onto salads. It kept the vegetables free of bacteria, but it is hardly a healthy option for the consumers. He investigated nature and found that oxythiocynate ions, otherwise known as OSCN are present in tears, saliva and mother’s milk and appear to destroy many pathogens including viruses, since OSCNs are literally the first line of immune defence. Thereafter, he created the world’s first supplement containing OSCN molecules. Soon it was realised that they also had massive health implications. An OSCN kit OSCNs have a very short half-life, something like 30 minutes, which is why you have never seen them presented in a supplement before. But 1st Line™ is different because it is a kit containing the active and 3 enzymes to make up the supplement in a glass of water for consumption straight away. It is easy to use, simply add the 4 agents in the right order (marked 1-2-3-4), stir and drink. 1st Line™ has no smell or flavor. Doing so creates 25 mg of OSCN, the equivalent to what a healthy body produces in a day. How to use Obviously, there are a plethora of infections out there, but on a simple level take a 1st Line™ dose at the first sign of infection and repeat the dose for a day or two afterward, as necessary. For maintenance, some individuals like to take one dose of 1st Line every month in order to keep the ‘body burdens’ low.

ACF228® - THE ULTIMATE FREE RADICAL SCAVENGER The ACF abbreviation means ‘antioxidant complete formula’ and 228 because it was Dr. Richard Lippman’s 228th formula that proved to be very effective. Dr. Richard Lippman was nominated for the Nobel Prize in medicine for his work in measuring free radical activity in-vivo; in other words what happens within the human body. The result of that work led to the incredibly comprehensive formula known as ACF228®. Free radicals Free radicals are unstable molecules that can be created ‘naturally’ within the body and they can ‘disorganise’ healthy cells by crashing around- a bit like bumper cars at a fayre. The free radical theory of aging was first proposed by Professor Denham Harman in the late 1950s and it helps to explain the degenerative processes that occur during aging. Hierarchy There are several levels of free radicals, and the worst of them are the superoxide and the hydroxyl free radicals. Neutralisation of ‘higher level’ free radicals can create a plethora of lower level free radicals, so it is important to try and impact every stage, but of course to particularly target the most destructive free radicals. Potency In the ACF228® formula there are numerous unique molecules like catalase and especially NDGA within ACF228®. Synergy ACF228® has numerous synergistic agents that have been designed to help neutralise every level of free radicals, no other single product has been in-vivo designed- each ACF228® capsule contains: N-acetylcysteine L-methione Di-indole-methane L-carnosine Deodorised garlic Trans resveratrol Vitamin B6 NDGA Potassium iodide Iodine Methylfolate Chromium picolinate Selenium Vitamin B12 Catalase

100 mg 100 mg 83 mg 83 mg 50 mg 17 mg 17 mg 3 mg 3 mg 2.5 mg 800 mcg 120 mcg 100 mcg 10 mcg 0.025 mg

Dose ACF228® has been designed as a one capsule per day formula. 28

AGINGMATTERS

The most versatile eyedrop on the market

Can-C™ eye-drops are the original formula containing n-acetylcarnosine (NAC), a natural di-peptide that has potent anti-glycating and antioxidant properties to prevent lipid peroxidation. Patients who placed 2-drops of Can-C™ into their eyes twice daily for a 5/6-month period reported: • An improvement in their visual acuity (90%) • An improvement in the clarity of their lens (88.9%) The most commonly expressed initial reports are that glare is significantly improved, (for example night driving is easier) and color perception is enhanced.

SPOTLIGHT

CAN-C™ EYE-DROPS - A BREAKTHROUGH FOR CATARACT Can-C™ eye-drops are the original formula containing n-acetylcarnosine (NAC), a natural di-peptide that has potent anti-glycating and antioxidant properties to prevent lipid peroxidation. Clinicals Patients who placed 2-drops of Can-C™ into their eyes twice daily for a 5/6-month period reported: • An improvement in their visual acuity (90%) • An improvement in the clarity of their lens (88.9%) There have been numerous reports of cataract shrinkage and even disappearance with documented evidence that Can-C™ eye-drops remain effective (and safe) more than 24-months later.

BEC5® CURADERM - A TRULY AMAZING SKIN CREAM The story of BEC5® cream is remarkable. When it is told people often can’t believe it- and when they realise the cream has been available for decades, they become flabbergasted! How so? Because this naturally derived skin cream has been shown to be virtually 100% effective in removing basal and squamous cell skin cancers (sic). History It all starts on the island of Vanuatu in the South Pacific, when a young man by the name of Bill Edward Cham (BEC) walked around the fields and noticed horses and cows rubbing themselves against a local plant called the Devil’s Apple, (a member of the eggplant family). Asking the farmers why they did this, he learnt that the animals had skin lesions and the rubbing helped clear them up. As Dr. Cham was training to be a biochemist this fascinated him and over 20+ years his research revealed a remarkable secret. Skin cancers He identified that the active ingredient was solasdines and that it ‘ate away’ a ribose coating on cancer cells that isn’t present on healthy cells. The result is that the cancer cells are exposed to the immune system as ‘non-self’ cells, then the natural process of apoptosis is induced and then the body rids itself of the cancer cells. Documented history Many journals, particularly those in Australasia have published these studies and numerous magazines around the world have divulged this. Two excellent books on this subject are; the eggplant cancer cure and Curaderm a non-invasive medication for skin cancer. Application BEC5® cream is applied topically to SCC and BCC lesions twice a day and covered with a micropore. The typical treatment time is between 6 to 12 weeks. So why hasn’t this cream, (that avoids the need for surgery in most cases) not become famous and mainstream? The answer is simple, the active agent is natural and can’t be patented and therefore the current medical system will not promote it. Note BEC5® is not suitable for melanoma cancers. 30

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Actuals The most commonly expressed initial reports are that glare is significantly improved, (for example night driving is easier) and color perception is enhanced. Most importantly, is an ability to read eye charts clearer, due to the better transmissivity of the lens Broad spectrum Evidence is mounting that Can-C™ is efficacious for many conditions including: • Cataracts (particularly the senile version) for both humans and dogs • Glaucoma • Presbyopia • Eye strain • Ocular inflammation • Blurred vision • Vitreous opacities and lesions • Diabetes mellitus complications • Contact lens comfort • Dry eye syndrome

SPOTLIGHT

CENTRO-PRO™ - IMPROVING MENTAL RECALL SPEED Centro-Pro™ capsules contain centrophenoxine, (pronounced, centrow-fen-ox-in) and it is a classic ‘nootropic.’ Background It comprises of two DMAE molecules bonded, (a substance found in nature). Centrophenoxine has been studied extensively for many decades in Europe and one of its leading proponents is the Gerontology expert, Professor Imre Zs.- Nagy, who utilises it for his own antiaging purposes and to keep his mind sharp. Actions • Centrophenoxine can increase acetylcholine levels in the brain. • It is also very effective in reducing lipofuscin levels, this component is part of Alzheimer brain plaques. • Accordingly, this reduction of membrane toxins like lipofuscin aids cellular communication. This is a key feature of the membrane hypothesis of aging- which has been published by Professor Nagy.

DEP-PRO™ - FOR FOCUS AND CONCENTRATION Dep-Pro™ contains deprenyl (also known as selegiline), it was created in the 1960s by Professor Joseph Knoll to treat Parkinson’s patientssince deprenyl improves dopamine levels.

• Thus, centrophenoxine is useful for those concerned about Alzheimer’s, but in addition, centrophenoxine has been noted to help enhance and protect the performance of an healthy, aging individual.

Significant longevity studies Professor Knoll’s experiments with rats also produced the most incredible longevity benefits. When the animals were fed deprenyl in their food, they lived so much longer that even after the last nontreated rat died, the first of the deprenyl treated rats was yet to die! (Note: importantly, these results were verified independently in another study not undertaken by Professor Knoll).

General cognitive benefits Classifying the precise benefits of the various nootropics can be tricky. Many people simply refer to their ailing cognitive facilities as “memory loss.” However, a quick breakdown of that statement requires further evaluation- in order to determine the precise nature of the problem.

Based on this research, Dean, Fowkes and Morgenthaler, published in the book, Smart Drugs and Nutrients, that the loss of dopamine in aging humans can be mapped against both the development of Parkinson’s and even death.

In such a case, centrophenoxine is perhaps best suited to the issue of recall speed. So, If your speech appears to be full of “ums” and “ers” (whilst your brain tries to catch up with your mouth), then it is likely that centrophenoxine will be an aid; helping to bring clarity and flow to speech and thought.

Mode of action For a long time deprenyl has been described as a MAO-b inhibitor, that it to say that is prevents this enzyme from destroying dopamine, leading to its improvement.

Doses A typical dose for the ‘average’ person is 250 mg once or twice daily.

Later, Professor Knoll noted that deprenyl also raises PEA levels and catecholamine sensitivity. Typical responses Deprenyl can assist: • The treatment of Parkinson’s and other dementias. • Male libido enhancement. • Boost metal energy levels especially focus and attention. • Life expectancy, at least in animals. Dosing Parkinson’s patients use high doses, but healthy aging adults typically use 1 mg to 3 mg per day, this is dependent on age and need. Note: Occasional breaks are recommended, such as one week off a month, or alternatively not taken at weekends. Note These doses do not consider synergy with other dopamine enhancing agents and, in such cases, would have to be adjusted accordingly.

AGINGMATTERS 31

SPOTLIGHT

GHRPS - AN ALTERNATIVE TO GROWTH HORMONE INJECTIONS Dr. Daniel Rudman’s research in the late 1980s concluded that elderly patients using Growth Hormone (GH) could reverse their biological age-markers by as much as 20-years! Specifically, he noted that they had improved the patients’ skin, hair, muscle mass, decreased fat levels and enhanced levels of stamina, strength and well-being. The issue with GH, (other than its expense), is that it does have to be injected to be effective; this is because it is a 191-chain of aminoacids so it simply can’t be absorbed via any other route. Furthermore, many countries have classified GH injections as a controlled substance, partly because of its anabolic actions. GHRPs Thankfully, Dr. Walker’s research has shown that the use of GHRPs, (growth hormone releasing peptides) have a much safer profile whilst enjoying many of the same benefits.

NATURAL ESTROGENS AND PROGESTERONE FOR WOMEN - NHRT IS THE RIGHT KIND OF ‘HRT’ When estrogens were discovered in the 1920s they had to be derived from pregnant mare urine- all because a laboratory solution was too expensive to synthesize. But today everything has changed, yet this ancient practice continues! These facts have been pointed out by Jonathan Wright, M.D. in his book; ‘Don’t let your doctor give you horse urine!’ Esnatri™- a unique tri-estrogen Esnatri™ is a bioidentical triple estrogen cream. It comes directly from the work of Dr. Jonathan Wright who has highlighted that most women produce estrogens in the ratios of 90% estriol, 7% estrone and 3% estrone. Usually, tri-estrogen preparations attempt to replicate the human hormones estriol, estradiol and estrone, in the ratio of 80:10:10. Some bi-estrogens entirely overlook estriol, claiming it is a ‘weak’ estrogen. However, women naturally produce high levels of estriol since it is considered to have anti-carcinogenic effects. Horse estrogens are, as you would expect, not identical to human. Yet some physicians still prescribe them, even though bioidentical estrogens can now be easily produced. Some people believe that the known side-effects from ‘HRT’ are because the correct natural human hormones are not utilised. In other words, women should be using ‘nHRT.’ Progest-Pro™ Progest-Pro™ is a 5% bioidentical progesterone cream and it is a counterbalance to estrogens. For whilst women can significantly decline in estrogen levels during menopause, they rarely reach zero production levels, whereas progesterone can sometimes not be measured at all. It is also the low level of progesterone that significantly impacts bone strength, leading onto osteoporosis. So, there are numerous reasons to ensure that progesterone is taken alongside estrogen in an nHRT program.

AGINGMATTERS

GHRPs can be sublingually and intranasally, and thus avoid the need for needles. • The GHRP feedback loop means that they cannot cause the pituitary to down-regulate production of GH. • GHRPs are not controlled substances. • Rather than inducing a spike of GH in the blood, GHRPs augment GH naturally into the blood. Synergy The main GHRP is GHRP2 which can be used sublingually, in addition there is also intranasal Sermorelin- this is the precursor to GH, (the first 29-aminoacids). Its function is to release existing stores of GH from the pituitary, rather than encourage more production. Dr. Walker suggests that combining sermorelin with GHRP2 can elicit up to a 5x greater quantity of GH into blood. Summary GHRPs have created a genuine alternative to GH injections; they are simpler and easier to use and at the same time they have a safer profile.

SPOTLIGHT

MET-PRO™ - IMPROVING THE INSULIN SENSITIVITY Met-Pro™ contains metformin, a diabetes type-2 treatment that has been used for many decades.

MZS™ - BECAUSE NOT ALL MELATONINS’ ARE CREATED EQUAL

Metformin differs from other insulin medications, since rather than increasing the production of insulin from the pancreas, it improves the sensitivity of the receptor site to insulin; in other words you ‘get more bang for your buck’ by improving the performance of insulin to peripheral tissues, (like muscles).

Melatonin is produced at night by the pineal gland to help regulate the circadian rhythm. As we age, the amount of melatonin we produce declines and it results in many persons having a lower quality of sleep.

This has interesting implications for aging since the neuroendocrine theory of aging teaches us that it is the loss of sensitivity at receptors that is a major ‘fault’ in aging.

MZS™ has been formulated by the world’s foremost melatonin expertDr. Walter Pierpaoli, his MZS™ (melatonin, plus zinc and selenium), is totally unique since it is designed to mimic the natural night peak of melatonin- leaving you refreshed and alert the following day.

Weight loss Persons who utilise metformin, (even those who may be pre-diabetic or otherwise not affected), have often noted that it helps them to maintain a healthy weight with lower fat levels etc.

What does melatonin do? Melatonin is vital to protect our hormonal system, regulate immunity and repair our body’s cells. It is commonly used by shift workers and to treat jet-lag and age-related sleep disorders, but its abilities go far beyond its sleep improvement properties.

Antiaging Dr. Ward Dean has stated that; “metformin is one of the most promising antiaging, life-extending drugs available.”

Antioxidant effects Melatonin is an extremely effective antioxidant; in fact, on a molecule to molecule basis, melatonin has proved to be more efficient in neutralizing toxic hydroxyl-radicals than the two well-known free radical scavengers, glutathione and mannitol.

It’s a profound statement, but it is predicated on the amazing range of metformin’s clinical effects which include: • Lowering the blood cholesterol, triglycerides and beta lipo-proteins. • Reducing the development of atherosclerosis. • Reducing insulin levels. • Increasing hypothalamo-pituitary sensitivity. • Improving the cellular immunity. • Enhancing the activity of anti-cancer drugs. • Suppressing the growth of some tumors. • Increasing the maximum life span of animals.

Melatonin and longevity Melatonin’s effect on longevity is well documented. Laboratory tests on animals have demonstrated that melatonin increased their lifespans by 20%. MZS™ and ARMD Age related macular degeneration comes in two forms, wet and dry and it is a notoriously difficult disorder to treat- linked to blindness. In a 24-month study, (NY Academy of Science, 2005, 1057:384-392) on 100 patients showed that after 3 months, the majority of patients taking 3 mg of MZS™ nightly had halted the progression of their AMRD and at 6 months many reversed their ARMD. Remarkably this was true for both the wet and dry forms!

Miles Metformin is a milestone, since it is the first medicine in the world to be granted an FDA approved study for antiaging titled; metformin in longevity study.

Dr. Pierpaoli’s melatonin Dr. Pierpaoli’s MZS™ formula mimics the pineal gland’s release of melatonin when it is taken between 9-11 PM because it releases between 1-3 AM, the natural night-peak of melatonin in blood.

Note Metformin does inhibit the uptake of vitamin B12, so in order to counter potential side-effects it is recommended to supplement with B12 at the same time.

AGINGMATTERS 33

Enjoy a sound night’s sleep Dr Pierpaoli’s unique time release formula Melatonin, a key ingredient of MZS™ is commonly used to treat age related sleep disorders, and has abilities that go far beyond simply its sleep inducing properties. It is vital to protect our hormonal system, regulate immunity and repair our body’s cells. MZS™ is the only melatonin supplement to follow nature’s own night peak 120

MELATONIN

100 80 60 40 20 0 9pm

10pm

11pm

12pm

1am

2am

3am

TIME OF DAY Melatonin natural release

Slow release formula

Ordinary sublingual melatonin

Dr Pierpaoli's formula

For more information on MZS™ visit antiaging-systems.com

4am

SPOTLIGHT

OXY-PRO™ - FOR PASSION AND SEX Oxy-Pro™ contains oxytocin, a hormone produced by the hypothalamus but excreted via the pituitary gland. Its orthodox role is to help women give birth, since the large dose that’s injected helps relax the uterus and alleviates the passage of the child. Meanwhile, Dr. Thierry Hertoghe’s book; ‘passion, sex and longevity, the oxytocin adventure’- has shown it to have many other roles. The love hormone Oxytocin has been dubbed ‘the love hormone’. This is because oxytocin can induce feelings of bonding and care. Not just between individuals, but even with animals too!

NATURE’S MARVELS™ - HOW PEPTIDE BIOREGULATORS IN FOOD ARE GENE SWITCHES Professor Vladimir Khavinson is the President of the European Academy of Gerontology and Geriatrics. In the 1980’s he was a Colonel in the Soviet Union military medical corps. He and his team were approached by Kremlin who wanted a way to protect their troops from various problems. The research uncovered a remarkable link between short-chain peptides and DNA. Basically, short-chain peptides- in foodact as gene specific switches; they termed them ‘peptide bioregulators.’

Oxytocin measurements have been taken between lovers, friends, relatives, parents and their children etc. From those results, it has been noted that oxytocin levels are higher when they are in their presence. Mothers naturally bond with their children, but even men, (especially those who experience the live birth), express their emotions as wanting to care and protect their offspring, these effects may be attributable to the release of oxytocin, hence triggering the bond.

This former military secret is now available and to-date 21 have been identified to assist various organs, glands and tissues. These peptides, unlike proteins, can enter through the stomach and a comprehensive list of patents, confirms that each of the peptide bioregulators interact with DNA - activating repair and regenerative processes.

On the other side of the coin, psychopaths are notoriously low in their oxytocin levels, which may be a cause of their uncaring feelings towards other humans.

Original materials from the trials Nature’s Marvels™ are the English packaged and approved peptide bioregulators from Professor Khavinson, (all bovine sourced).

The pain and orgasm connection Fibromyalgia can be a very debilitating disorder with a lot of pain, sometimes constant for those who suffer with it.

Here is the complete list:

In women with fibromyalgia it was noted that when they were experiencing an orgasm, they felt no pain at all. Later, it transpired that women undergo a burst of oxytocin during orgasm.

1. Adrenal 2. Bladder 3. Blood vessels 4. Bone marrow 5. Brain (CNS) 6. Cartilage 7. Heart 8. Kidney 9. Liver 10. Lung 11. Muscle 12. Ovaries 13. Pancreas 14. Parathyroid 15. Pineal 16. Prostate 17. Retina 18. Stomach 19. Testes 20. Thymus 21. Thyroid

Trials were undertaken to see if oxytocin supplementation could alleviate the pain of fibromyalgia, there was some success, but the sideeffect noted was that those women now enjoyed multiple orgasms! This was a fact picked up on by the popular press and is probably singularly the action most responsible for bringing oxytocin into the public gaze.

Dosing A typical program is as follows: • Start with an intensive course of 2-capsules once a day for 30-days. • Thereafter, use 2-capsules once a day for 10-days, repeat every 1, 2 or 3 months.

AGINGMATTERS 35

SPOTLIGHT

PIRA-PRO™ - THE ORIGINAL NOOTROPIC Nootropic is a term meaning ‘towards the mind’ and they were originally designed for senile dementias, but now they have become popular for aging individuals to enhance their mental and cognitive processes. Ward Dean, M.D. has highlighted these facts in his ‘Smart Drug’ series of books; ever since then the term ‘smart drugs’ has become mainstream. Piracetam, the original Pira-Pro™ contains piracetam and piracetam was the first nootropic developed by Dr. Giurgea at UCB in the 1960s. Originally, it was used for travel and altitude sickness, but shortly afterward people realised that piracetam had positive effects on cognition. What does piracetam do? Piracetam is used for a wide range of conditions. For example, it has been shown to improve attention levels and memory retention. Piracetam can slow down ‘senile involution.’ In other trials, piracetam has improved memory consolidation in those suffering from ‘age-related memory impairment.’ Piracetam has aided patients recovering from strokes, in-particular improving post stroke speech impairment (aphasia). Another use has been for acute and chronic cerebral ischaemia, (decreased blood flow to the brain). Piracetam has even increased neuronal activity in the brain when measured with EEG. For normal individuals, piracetam can enhance idea creation and the ability to ‘see things through.’ In other words, to have ideas and then be able to bring them to fruition. The level of clarity piracetam induces is often described as; “the fog has lifted.” How does piracetam work? Piracetam’s key method of action is upon the Corpus Callosum, the region of the brain that links the two hemispheres. Many experts believe this enables piracetam users to channel greater brain potential by connecting the logical side of the brain with the creative side. This could be described as a Yin and Yang effect.

THYROIDS - SUPPORTING THE HYPOTHYROID EPIDEMIC Dr. Broda Barnes estimated that 40% of adults are deficient in thyroid hormones. As the thyroid gland is of pivotal importance, a lack of its function can affect a wide variety of age-related health disorders. Ergo, supplementation can have many positive effects. The thyroid gland The thyroid controls the body's metabolism, (the rate at which it burns calories for energy) and the body's utilization of fat; so a decline in thyroid function, can result in poor concentration, confusion, memory problems, cold hands and feet and weight gain. Other conditions triggered by an underactive thyroid are painful musculoskeletal issues that affect tendons, muscles and ligaments. Do I need a thyroid supplement? A doctor can check your blood levels, but a simple method is to take your body temperature when you wake in the morning. It should be in the range of 97.8 to 98.2 degrees Fahrenheit. If it is regularly lower than 97.8 F you could be hypothyroid and if regularly higher than 98.2 F then hyperthyroid. Synthetic vs. natural thyroids Synthetic thyroids typically only contain T3 or T4, but natural thyroids (like Armour® etc.) are of porcine origin and contain the full spectrum of T1, T2, T3 and T4 thyroid hormones. Converting between the two The table provides a helpful guide to the conversion rates for those wishing to switch from synthetic thyroids to natural versions. As always, we recommend consulting with a physician before making changes to your health program. Dose of

Dose of T3

Dose of T4

Dessicated

(Lithytonine)

(Levothyroxine)

Thyroid (Grains)

(mcg)

12.5

0.5

AGINGMATTERS

Equivalents (mg)

100

130

200

300

260

100

400

325

125

500

Described by scientists as “Nature’s gene switches” that could replace stem cells Professor Khavinsons Peptide Bioregulators

For more information on Nature’s MarvelsTM products visit naturesmarvels.com

ANTIAGING SYSTEMS

ANTIAGING-SYSTEMS.COM www.antiaging-systems.com is your comprehensive resource for information about all the leading commercially available antiaging, preventative and regenerative products and therapies available today. Visit www.antiaging-systems.com and find articles, videos, audio-files, all referenced with a guide of where to obtain your needs. Currently the site covers topics related to all the following products. BOOKS

–– Atlas of Endocrinology

–– Cataract Cure

–– Eyesight Saviors

–– Great Teeth for Life

–– Melatonin, the Key of Life

–– Natural Skin Cancer Treatments

–– Passion, Sex & Oxytocin

–– Peptides in the Control of Ageing

–– Peptide Biomarker Revolution

–– Physician Hormone Handbook V2

–– Reversing Physical Aging V1

DIAGNOSTICS

–– Bio-Clip™ CUFF

–– Foodsafe®

GHRPS

–– GHRP2 (GHRP2-Pro™)

–– Sermorelin (Serm-Pro™)

HORMONES

–– Aldosterone (Aldo-Pro™)

–– DHEA (DHEA-Pro™)

–– Estrogens (Esnatri™)

–– HCG (HCG-Pro™)

–– Hydrocortisone (Hydrocort-Pro™)

–– Melatonin (MZS™)

–– MSH2 (MSH2-Pro™)

–– Oxytocin (Oxy-Pro™)

–– Pregnenolone (Preg-Pro™)

–– Progesterone (Progest-Pro™)

–– Thymus

–– Thyroid (Armour™ etc.)

–– TRH (Abaris™)

–– Vasopressin (Vaso-Pro™)

NUTRITION

–– 1st Line™ (OSCN)

–– Beta-Glucans (BG-Pro™)

–– Boluoke® (Lumbrokinase)

–– Benfotiamine (Milgamma™)

–– Boost-Pro™

–– Can-C™ + capsules

–– Boluoke (Lumbrokinase)

–– ACF-228

AGINGMATTERS

ANTIAGING SYSTEMS

–– Carnosine (Carno-Pro™)

–– Symprove®

–– GCB70-Pro™

–– DIM (DIM-Pro3™)

–– Vitamin D3 (D3-5000™)

–– NAD+ (NAD+Pro™)

–– L-tryptophan (Ltryp-Pro™)

–– MultiV45-Pro™

–– Nitric-Pro™

–– NADH

–– PEA (Pain-Pro™)

–– Sleep-Pro™

–– Novisyn (Hyaluronan)

–– TA65 capsules (100)

–– Vitamin B12 (B12-Pro™)

–– PQQ (PQQ-Pro™)

–– TA65 capsules (250)

® ®

PEPTIDE BIOREGULATORS

–– Adrenal (Glandokort®)

–– Bladder (Chitomur®)

–– Blood Cell (Ventfort®)

–– Bone Marrow (Bonomarlot®)

–– Cartilage (Sigumir®)

–– CNS/ Brain (Cerluten®)

–– Heart (Chelohart®)

–– Kidney (Pielotax®)

–– Liver (Svetinorm®)

–– Lungs (Taxorest®)

–– Muscle (Gotratix®)

–– Ovaries (Zhenoluten®)

–– Pancreas (Suprefort®)

–– Parathyroid (Bonothyrk®)

–– Pineal (Endoluten®)

–– Prostate (Libidon®)

–– Retina (Visoluten®)

–– Stomach (Stamakort®)

–– Testes (Testoluten®)

–– Thymus (Vladonix®)

–– Thyroid (Thyreogen®)

–– Adrafinil (Adra-Pro™)

–– Picamilone (Picamilon-Pro™)

–– Piracetam (Pira-Pro™)

–– Deprenyl (Dep-Pro™)

–– Reminyl® (Galantamine)

–– Vinpocetine (Vin-Pro™)

–– Modafinil (Moda-Pro™)

–– Centrophenoxine (Centro-Pro™)

–– Hydergine (Hy-Pro3™)

–– Idebenone (Ideb-Pro™)

SMARTS

SPECIALIST (INCLUDING MEDICINES)

–– B17-Pro™ (amadaylin)

–– 4MU (4MU-Pro™)

–– Acarbose (Glucobay®)

–– Anastrozole (Arimidex®)

–– ATP-Pro™

–– BHT (BHT-Pro™)

–– Bromocriptine (Parlodel )

–– EDTA (EDTA-Pro™)

–– Doxycycline

–– Dutasteride (Avodart )

–– Metformin (Met-Pro™)

–– Finasteride (Proscar )

–– Gerovital-H3® (GH3-Pro™)

–– Reminyl® (galantamine)

–– Naltrexone (Nal-Pro™)

–– Sildenafil (Sildenafil-Pro™)

–– SAMe (SAMe-Pro™)

–– Aminoguanidine (Amino-Pro™)

–– DMSA (DMSA-Pro™) ®

TOPICALS

–– BEC5® Curaderm cream

–– NeyDent® toothpaste

–– OraltidePRO™ mouthwash

–– Minmax-Pro™

–– TA65® cream

–– Youth Gems®

–– Can-C™ eye-drops

–– Joint-Pro™ cream

AGINGMATTERS 39

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