Aging Matters Issue 1, 2015 by International Antiaging Systems (IAS)

No 1, 2015

US $8.00/ EU €6.00/ GB £5.00 where sold

PLANTS vsFISH Why Plants Win Professor Brian Peskin explains the science

PLUS: The intelligence ergoloid FOREFRONT – This month’s news Dr Ward Dean answers ADHD

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WELCOME This may be one of our most controversial cover stories. However, its writer - Professor Brian Peskin, has gotten used to the controversy as he continues to break down the existing belief systems around fish oils with science, highlighting the advantages of plant oils, (the so called PEOs or ‘parent essential oils’). Whatever your stance, I think you will find it a fascinating read, indeed we here at IAS felt we had to take notice of it. It’s also great to have the ‘ergoloid mesylate’ updated, (originally known as Hydergine® when it was made by Novartis). The Swiss Pharma company have now withdrawn it from their line because of commercial reasons, but considering that Novartis have gone public about focusing on aging and its degenerative diseases recently, I feel that they’ve lost a star from their lineup, as you will learn when you read the article. Naturally though, IAS has found an alternative. Meanwhile, Dr. Dean decided that a question about ADHD, (what used to be known as ADD, or attention deficit disorder), needed a long and complete answer. So this period, Dr. Dean answers one question! As usual, I hope you enjoy and benefit from our epistle.

Phil Micans, MS, PharmB Editor, Aging Matters™ Magazine Ward Dean, M.D., Medical Director

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Welcome -Phil says thanks for finding the time 3 Forefront -This month’s news 5 The Power of PEOs -Professor Peskin explains the science 6 The intelligence ergoloid -Updating the benefits of Hydergine® 13 Dr Ward Dean Q&A -Dr Dean answers your questions 18 Featured products -Best sellers and new items 23 Testimonials & Explanations -Nice people, nice comments 32 Complete product A-Z list and prices -Find everything in stock here 33 Condition cross-reference list -Find the right product for you 45 Payment -The options across the IAS websites 50

• Product quality: We only stock the best quality products. With the right materials and formulation you are more likely to get the results you desire. • Original brands: We have the original brands - i.e. the same ones used in the clinical trials. These brands are used by top health professionals. • Choice: The largest range of medicines, hormones and supplements. If you are looking for things that use words like bioidentical, efficacy and synergy then you’ve come to the right place. • Competitive pricing: All products are discounted from their suggested retail prices. We regularly have special offers to help you save money on the things that are important to you and your family. • Customer support: Our friendly and professional customer care team are on-hand to help you. We care about you and we can be bothered! Reach us by phone, fax, e-mail, Skype and even by letter! • Professional articles: We work alongside the leaders in the field and we review the latest research to ensure that everything is up-to-date. After all, if we are informed then so are you! • Supporting worthy organisations: All over the world you will find IAS supporting, sponsoring, exhibiting and lecturing at key venues. You can meet us in person and see what we believe in.

Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members and focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the main focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual. Copyright 2015: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents. Disclaimer: All educational information is offered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. All prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice.

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FOREFRONT

The things you need to know from this month’s news

Dying for a Soda? New research from the University of California, San Francisco tested for a link between consuming sugary drinks and cell aging. What metric did they chose to use to measure aging? – Telomere length. As regular readers of ‘Aging Matters’ will no doubt be aware the shorter the telomere, the less a cell can regenerate, indicating accelerated aging and an increased risk of disease and early death. The findings revealed that the more of a certain type of sugary drink the participants consumed, the shorter their telomeres turned out to be. What can be done to offset shortening of telomeres, there is only one telomerase activator proven to work in humans TA65. We featured an interview with the Founder and Chairman of TA Sciences, Mr Noel Thomas Patton called “The Long and Short of it” in Issue 1 2014 that can be read in full on antiaging-systems.com

Did you know? The more of a certain type of sugary drink the participants consumed, the shorter their telomeres turned out to be.

Statins and Prescription Drugs A recent study has revealed some shocking statistics regarding the number of prescriptions people are taking. It was found that half of women and over 40% of men were taking at least one prescription medicine in England. The recent recommendations from NICE to the UK government that almost everyone over 60 should be taking a cholesterol lowering statin powering these alarming figures. Statins are a controversial subject with many questioning big pharma’s hand in the research which has led to such widespread adoption and also the quality of the research itself. As the debate rages we would recommend if you are prescribed a statin make sure you also take CoQ10. Statins deplete the body of the essential nutrient CoQ10. In parts of Europe when a statin is prescribed it must be accom-

panied by supplementation with CoQ10. This is not done in the USA or the UK, and even if it were what is not commonly acknowledged is that most CoQ10 products are poorly absorbed by the body. We recently introduced our CoQ10sr which has a patented technology which uses cyclodextrin to improve bioavailability whilst at the same providing a sustained slow release. For more information about how CoQ10sr works and what it is capable of read our article “CoQ10sr Patented Delivery System Doubles CoQ10 Blood Levels in Three Weeks” on antiaging-systems.com

“Statins deplete the body of the essential nutrient CoQ10.” www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

The Power of the Parent Essential Oils - the PEO solution

By Professor Brian Scott Peskin

Professor Brian S. Peskin, BSEE-MIT, Founder of Life-Systems Engineering Science, is the world’s foremost international lecturer and authority on physiologic plant-based oils and the highly acclaimed author of the landmark book, The Hidden Story of Cancer. A graduate of the prestigious Massachusetts Institute of Technology, he received an appointment as adjunct professor, Department of Pharmacy and Health Sciences at Texas Southern University (1998-1999). Physicians around the world rely on his insights and conclusions. Prof. Peskin is the “Physician’s Resource for PEO-based Solutions. What you are about to read may shock you, but the information is not opinion. The hypotheses are based on state-of-the-art medical science. This paper provides the truth about EFAs--essential fatty acids--what they are and what they aren’t. What is currently erroneously termed an EFA isn’t actually an EFA. I am often asked how my EFA-based recommendations differ from others. The answer is simple but very significant. The term “essential fatty acids” is being misused so frequently that I was compelled to coin a new phrase, Parent Essential Oils (PEOs). This term “Parent Essential Oils” refers to the only two true essential fatty acids: Parent omega-6 (linoleic acid, or LA) and Parent omega-3 (alpha-linolenic acid, or ALA). The term “Parent” is used because these are the whole, unadulterated, fully functional forms of the only two essential fats your body demands, as they occur in nature. Once PEOs are consumed, your body changes a small percentage--less than 1%--into other biochemical entities called “derivatives,” while leaving the remaining 99% in parent form. State-of-the-art 21st century analysis with positron emission testing (PET) proves this fact. Twenty-five to thirty-three percent (25-33%) of every cell membrane’s lipids are supposed to be PEOs! For much more extensive science, please see my book, PEO Solution, co-written with one of America’s leading integrative physicians, Robert Rowen, M.D.

LDL-C (cholesterol) is the transporter of PEOs Lowering LDL-C was a good 1st attempt at trying to reduce the adulterated Parent omega-6 in everyone’s diet. However, this method isn’t strong enough. That is why statins are only marginally (if at all) effective. The 21st century solution is to consume sufficient organic, unadulterated PEOs each and every day. Modern food processing and supermarket ease require their constant adulteration for long shelf life.

Phospholipids (with PEOs)

Cholesterol

Cholesterol esters (with PEOs)

Apoprotein B-100

Negative charges

Figure 1: The structure and composition of a low density lipoprotein showing the significance of its large esterified-meaning chemically tied to PEOs--cholesterol structure in its center.

Today, most cooking oils are based on Parent omega-6 (LA). For long shelf life, food processors adulterate these oils making them no longer oxygen-absorbing or fully functional. One hundred trillion (100,000,000,000) defective cell membranes would be expected to cause enormous health problems--and they do--from cardiovascular disease, to cancer, to diabetes. Even the finest restaurants use these adulterated oils! Ask yourself: How can we be so sick in spite of so many of us trying to do the right things regarding our health? There is only one logical conclusion. We aren’t solving the prime cause of our health problems--but now we can.

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Importance of special fats called PEOs Our bodies require special fats that make it possible, among other important functions, for sufficient oxygen to reach the cells. These special fats are highly oxygen-absorbing, and are called EFAs. However, it is the PEOs (Parent Essential Oils)--not the commonly mistermed EFAs-like EPA and DHA from fish oil--that are important. PEOs consist of parent omega-6 and parent omega-3. “Parent” means they are the whole form of the essential oil as it occurs in nature before it’s broken down or built up into other biochemical substances, which are called “derivatives.” Why are the parent forms, the PEOs so important? Many of the EFAs sold in stores consist of concentrated/processed EFA derivatives. Our bodies don’t need or want these overdoses of derivatives, because we make our own derivatives out of the Parent Essential Oils (PEOs) we consume, as we need them. Thus, taking fish oil and other health food store “EFAs” often overdoses patients with derivatives, which can be very harmful. However, PEOs are essential and must be supplied from outside the body every day, from foods and certain oils. Your body can’t manufacture PEOs (genuine EFAs, rather than EFA derivatives) on its own. PEOs MUST be consumed daily.

OXYGEN MAGNETS! Oxygen

EFAs

O2 O2 Oxygen Magnets

HEART

EFAs work like tiny “magnets” drawing oxygen into all cells, tissues and vital organs. Reduce oxygen by only 1/3 and a cell turns cancerous, forever!

LUNGS

“What you are about to read may shock you, but the information is not opinion.” The brain and nervous system comprise only 3% of total body weight. There are normally only small, trace amounts of these EPA/ DHA derivatives used in the brain, eyes and nervous system in the plasma, cellular membranes and tissues in the human body. Contrary to PEO requirements, extremely little is required for their daily replenishment. As shall be detailed shortly, marine and fish oil supplements in their suggested dosages, however, supply EPA & DHA in supraphysiologic amounts--often in excess of 100-fold, or even 500-fold amounts more than the body would ever naturally produce on its own! It is a mistake to recommend a derivative when the fully functional, unadulterated “Parent” EFA-Parent Essential Oil (or PEO)--is required. Research demonstrates that fish oil supplements consistently fail to prevent cardiovascular disease (CVD), cancer, and significantly worsen diabetic patients’ condition by raising blood sugars and blunting (lessening) the critical insulin response.1 Organic, unprocessed, fully functional parent essential oils--linoleic acid (LA-omega 6) and alpha-linolenic acid (ALA- omega 3)--in the correct physiologic ratio (containing more Parent omega-6 than Parent omega-3) can: 1. Help prevent and reverse existing cardiovascular disease, as is evidenced by the landmark cardiovascular screening IOWA Experiment (soon to be discussed); 2. Help prevent and slow down existing cancerous tumor growth; and 3. Significantly enhance cellular insulin sensitivity, to name a few....

Cellular oxygenation, the ultimate in antiaging science Figure 2: EFAs work like tiny ‘magnets’ drawing oxygen into all cells, tissues and vital organs, but reduce oxygen by one third and a cell turns cancerous!

Every one of our 100 trillion cells is surrounded by a bi-lipid membrane (a thin enclosure). The cell membrane is half fat. A portion of the fat making up the membrane is saturated. “Saturated” means chemically nonreactive--in other words, it doesn’t easily react with, or absorb, the oxygen and other biologic substances that come into contact with it. The other portion of the fat in the membrane is, however, “unsaturated” It on the other hand, DOES easily absorb oxygen. One of the major functions of unsaturated (also called polyunsaturated) fats in the cell membrane is to facilitate the passage of oxygen into our cells. Were these essential fats absent in cellular membranes, cells would starve for oxygen--even if the blood was oxygen rich. The saturated fats in the membrane function as a barrier to help protect the delicate, highly reactive, oxygen-absorbing, energizing, unsaturated fats in the membrane--in particular, Parent omega-6.

Parent omega-6, particularly in the cell membrane, acts as a cellular “oxygen magnet.” That is why patients have increased energy with PEOs. PEOs are the ultimate “energy drink.” The relationship between linoleic acid and sufficient cellular oxygen-Parent omega-6 was confirmed in a seminal study published decades ago in Pediatrics.2 “We have already reported that, although the saturates, such as palmitates, have little or no affinity for oxygen, the unsaturates [including PEOs] are capable of undergoing reversible oxygenation in response to changes in oxygen pressure. Because two unsaturated carbon-carbon bonds are required for the reaction, each linoleic [Parent omega-6] molecule can bind with one molecule of oxygen with it, but two oleic molecules bind one-oxygen between them.” [Note: Parent omega-6 is twice as effective in oxygen transfer.] * “Underwood’s group has shown that, in cystic fibrosis, the abnormality in fatty acid composition is not restricted to the erythrocytes and plasma. Interference with the movement of oxygen could then occur at any cell membrane so that there could be a general reduction in the supply of cellular oxygen throughout the body...” * “... Such a condition could depress the rate of cellular respiration, phosphorylation and all energy-dependent processes.” * “...It seems possible that many of their symptoms may result from essential fatty acid (linoleic) deficiency, leading to the decrease in the availability of cellular oxygen for respiration.”

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Appetite

• Less Cravings • Less Hunger • Better Appetite Fulfilment

Diabetes

• Less Sweet Cravings • Lower Blood Sugar • Less Neuropathy/ Retinopathy

Hormones/ Endocrine

• Better Sexual Function • Smoother Pregnancies • Less PMS • Fewer Headaches

Heart Health

• Flexible Arteries • Clean Arteries • Fast Blood Flow • Lower Blood Pressure • Improves Lipids

PEOs

SUPPORT

Brain Health

• Better Clarity • Better Focus • Improved Memory • Helps Improve ADD & ADHD

Beauty

• Healthier Skin • Less Dandruff • Less Cellulite • Healthier Hair • Eczema Improved

Anti-inflammation • Less Arthritis • Less Joint Pain/Swelling • Faster Healing

Endurance

PEOs are the “bricks & mortar” of each cell There are about one hundred trillion (100,000,000,000,000) cells in the human body (more or less). Half of every cell membrane is fat. Every cell’s bi-lipid membrane contains 25%-33% PEOs.3 Every mitochondrion-your cellular energy furnaces--typically hundreds to thousands per cell4--also contains PEOs. Evolutionary biologist Dr. Bruce Lipton understands how important the cell membrane is to “the intelligence” of the cell. Nobel Prize-winner Otto Warburg, MD, PhD stated: “... the plasma-membrane as such, and not because substances pass in-or-out through it, plays an important role in the oxidative metabolism [required for intelligence] of the cell.”5

“HEAD”

NONPOLAR, HYDROPHOBIC FATTY ACID “TAILS”

“HEAD”

• More Energy • Less Fatigue • Greater Intensity • Faster Recuperation

Figure 3: Now you can appreciate that PEOs supports a great deal of the body’s structure.

A quote from Robert Kagan, M.D., Radiologist (USA) (President Clinton appointee as the sole physician commissioner on the White House Fellowship Commission; Former Chairman of the Board of Nuclear Medicine Resource Committee of the College of American Pathologists; Past President of the Florida Association of Nuclear Physicians): “I previously wrote you about the remarkable cause/effect relationship in reversing plaque volume in a (smoking) patient taking conventional treatment, (i.e. statins, aspirin, Co-Q10). In reading over the [patient’s] scans, I have never seen such a remarkable result. When he [the patient] stopped the PEOs the plaque came back!”

A cause/effect relationship with the “power of the parents” All-important longer chain structures are made from the Parents by the body on an “as needed” basis. These are technically termed “longchain derivatives,” or (long chain) metabolites. I simply call them “derivatives.” The most well-known and significant derivatives are: * GLA (omega-6 series) substrate for PGE1, the body’s most powerful anti-inflammatory and vasodilator. * AA (omega-6 series) substrate for PGI2, the body’s most powerful natural “blood thinner,” platelet anti-aggregator, anti-adhesive, and vasodilator. Contrary to popular belief, AA is not harmful, required and is ubiquitous and contained by every cell membrane. * EPA (omega-3 series) very small amounts are produced naturally. * DHA (omega-3 series) very small amounts are produced naturally. The omega-3 series derivatives are very weak compared to the omega-6 series derivatives. However, once fish oil became the “supplement du jour,” rationality disappeared. Fish oil proponents claim that because the elongation pathways are the same for both series, and because omega-6 is “bad,” then having less is relatively “better.” Such tortured logic potentially harms the patient.

Advisory It is commonly thought and publicized that the real “power” of EFAs is solely in their long-chain metabolites (derivatives). However, this is categorically wrong and naïve. True, long-chain metabolites like GLA and AA--both of the Parent omega-6 series--are critical but there is more to the story...

AQUEOUS ENVIRONMENT

Figure 4: A Bi-lipid cell membrane: Note the extensive lipid fatty acid “tail” sections.

Old research from the 20th century was mistaken, and grossly overestimated the requirements for the derivatives of LA and ALA, which are DHA and EPA (docosahexaenoic acid and eicosapentaenoic acid) from marine oils. This is crucial to understand. As will be explained in more detail, patients unknowingly take overdoses of these derivatives in the form of fish oil and other supplements, rather than allowing their body to make the derivatives naturally from whole essential oils in the quantities actually needed. As a result, their medical problems are frequently not corrected, but are oftentimes made worse and both patient and physician have no idea why, but now you know why this occurs.

Newsflash: Your body makes “derivatives” from the parents “as needed” A mistake of monumental proportions was made when the medical community incorrectly assumed that all “Parents” would be converted to “derivatives.” Decades ago, it was very difficult to quantitatively measure how much EPA/DHA was used in the brain (the largest depository). This wrong assumption is harming millions of people. No one asked: Why are humans experiencing a fish oil deficiency all of a sudden? There was little fish oil supplementation in the 1940s through the 1970s. Did infants and adolescents suffer gross visual, neurological and brain impairments? No! This would be the case if there really were a deficiency. It is likely that no deficiency existed back then or exists today. In actuality, there is extremely little conversion of the delta-6 and delta-5 desaturation enzymes. Nature intentionally made it this way. There is no “slow” or impaired enzymatic activity causing deficiency of long chain metabolites from Parent omega-3 in the vast majority of patients. Yes, alcoholism and diabetes do impair the delta-6 pathway affecting the production of PGE1-the body’s most powerful anti-inflammatory--from GLA (an omega-6 metabolite). This is why I recommend GLA-containing oil in all Parent-based formulations.

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Today, inflammation is rampant in patients. Never forget that common adulteration of our cooking oils (all of which are omega-6based) we are ingesting a toxin on a daily basis-- adulterated Parent omega-6 (LA) from our food. Studies confirm that omega-3 derivatives are adequately produced by our bodies as the medical experiments below confirm:

No impairment of the Delta-6 desaturase enzyme in the general population Contrary to wrong dogma, the enzymes that produce PEO derivatives (the delta-6 and delta-5 desaturase enzymes) are not impaired in the vast majority of patients.6 Conversion of ALA [Parent omega-3] to DHA is unlikely to ever normally exceed 1% in humans.7 Research at the United States Department of Agriculture’s USDA food composition laboratory (2001) reported a natural net conversion rate of a mere 0.046% of ALA to DHA and 0.2% to EPA--not the highly misleading 15% conversion rate that is often-quoted.8 NIH researchers determined the amount of DHA utilized in human brain tissue to be a mere 3.8 mg ± 1.7 mg/day. Therefore, brain tissue in 95% of all subjects, allowing for variation in brain size, would require and use a mere 0.4 mg - 7.2 mg of DHA per day.6 New, twenty-first century quantitative research from both NIH and USDA show considerably lesser amounts of natural DHA conversion/usage from ALA than the medical community has been led to believe. These conversion amounts are extremely small and naturally limited. This mistake often leads to recommendations that are suprapharmacologic and can potentially overdose patients by factors of 20-fold to 500-fold, depending on the specific supplement and amounts consumed. The body cannot simply oxidize these tremendous overdoses of EPA/DHA; they are too great a quantity. There are more confirming articles such as analyzing vegetarians and finding they produced sufficient DHA even though they consumed no fish! The medical science is clear.

WARNING: Fish oil overdose causes cancer, heart disease, diabetes and much more damage... 21st century medical science can’t be ignored!

These articles should be required reading for all physicians and healthcare professionals. If physicians weren’t aware of the new 21st century medical science, they couldn’t be held responsible. But now they must be held responsible. If my articles aren’t sufficient, I have listed twenty-six (26) Inconvenient Truths about fish/marine oil that everyone needs to be aware of [See www.PEO-Solution.com - Scientific Support for Chapter 7). A particularly crushing blow to fish oil came from Eric Topol, MD, a prominent American cardiologist from the Scripps Institute: Dr. Topol is editor-in-chief of Medscape, editor-in-chief of theheart.org (Medscape’s on-line newsletter for cardiologists), and was voted as one of the most influential physician executives in the United States in 2012. Dr. Topol has this to say regarding the NJM finding that fish oil is worthless for helping cardiovascular disease:11 “I have an awful lot of patients that come to me on fish oil, and I implore them to stop taking it. Fish oil does nothing. We can’t continue to argue that we didn’t give the right dose or the right preparation. It is a nada effect. It’s been a fishy story for a long time.... Fish oil is a ‘no-go.’ If it doesn’t work in this group [high risk patients], it’s hard to imagine in lesser-risk groups that it’s going to have any salutary impact.” What more needs to be said? Nothing.

Ratio of Tissue Composition Tissue

Percentage of Total Body Weight

Omega-6 PEO

Omega-3 PEO

Brain/Nervous System

100

Skin*

1000

Oragns and Other Tissues

15-35

6.5

Adipose Tissue (body fat) Muscles

*There is virtually NO omega-3 in skin tissue.

Percentages of linoleic acid (LA) & alpha linoleic Acid (ALA) in Plasma & Classes of Lipids Plasma % (Unesterified)

Plasma % Triglycerides

LA (parent omega-6)

19.5

LA (parent omega-3)

1.1

0.2

0.5

Parent omega-6: Parent omega-3 Ratio

8.5:1

17.5:1

115:1

100:1

Fatty Acid

Therefore, these overdoses end up on the skin, which is not meant to contain any of the Parent or omega-3 metabolites. They are far too reactive to heat damage. This is a prime reason for the explosion in skin cancer, even though many of us stay out of the sun. The omega-3 metabolites are also forced into the cardiovascular system causing heart disease. The inner layer of the artery, termed the intima, is supposed to be comprised solely of Parent omega-6; that is, until wrong fish oil recommendations overdose you! Prostate cancer and breast cancer in women would be expected for the exact same reasons. An article recently appeared with the same conclusion.18 Of course, the medical community and the fish oil sellers were up in arms. My analyses are in the following journal articles: * “Why Fish Oil Fails to Prevent or Improve CVD: A 21st Century Analysis.”9 * “SELECT Trial Results Examined: Why Fish Oil, DHA and “Oily Fish” Are Inflammatory, Leading to Increases in Prostate Cancer, Epithelial Cancers and CVD,” and “nails the coffin shut” on the use of prophylactic fish oil in the general population.10

Plasma % Phospholipids

Plasma % Cholesterol Esters

Figure 5: Physiology leads the way to the truth - your body only wants very little Omega-312

PEOs vs fish oil-PEOs win every time The most significant experiment to date is “Investigating Oils With respect to Arterial health” (IOWA). The world renowned IOWA Screening Experiment9 had amazing results. Although I designed the study, I did not participate in any aspect of the screening. Group I (long-term PEOs only) results were an average decrease in “biological age” the arteries of 8.8 years compared to their chronological age. Seventy- three percent (73%) of all subjects improved their cardiovascular system. The subjects’ arteries were almost 9 years biologically younger. Group II (short-term PEOs) results were an average of 7.2 years decrease in “biological age” of their arteries. Forty-three percent (43%) of subjects improved in a very short time frame. Group III (stopped fish oil use and converted to PEOs) results were an average of 11.1 years decrease in “biological age”. Eighty seven percent (87%) of subjects improved in a very short time frame--the

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most significant improvement in any population. Fish oil consumption unequivocally made patients’ arteries HARDER! But fish oil is meant to be an “antiaging substance!” When renowned international authority in oxidative medicine Robert Rowen, MD-revered as America’s “Father of Medical Freedom” and Leader of Integrative Medicine for pioneering America’s first statutory protection for alternative medicine in 1990-saw this clinical result, he immediately became one of my strongest supporters. He also became my co-author for our new book, PEO Solution.

Figure 6: WARNING: Fish oil is typically a highly processed food... Fish oils come from “juiced fish.”

IOWA: Results with additional patient risk factors Seven subjects had “high” cholesterol levels while taking fish oil supplements before changing to PEOs. Six of the seven patients decreased their cardiovascular “biological age” by ceasing fish oil and converting to PEOs-an 83% effectiveness rate in this sub-group. One subject with both “high cholesterol” and diabetes improved after replacing fish oil with PEOs. Two subjects taking statins decreased their cardiovascular biological age by 20 years after ceasing fish oil and replacing with PEOs. The most remarkable finding was that subjects taking fish oil prior to PEOs obtained the most improvement! This was anticipated since they started at a greater deficit. Ceasing fish oil use allowed the arterial system to revert to “normal” instead of making the vascular system less flexible by its use. Once the vascular system was back to “normal,” the expected improvement from PEOs, as shown by the other groups, was also achieved, resulting in an even greater decrease in biological age. It takes a full 18 weeks to fully rid patients of the negative effects of fish oil, as the superb 2003 British Medical Journal of Nutrition article makes clear.13 The subjects in the IOWA experiment were measured at an average of 14 weeks after ceasing fish oil usage. If they had been measured at the full 18 weeks, we might have seen even greater decreases in arterial “biological age.” We are misled time after time about what is best for us. For example, saturated fat was vilified for decades. We were told not to eat cheese, bacon, butter, or cream. However, it was known that there was no saturated fat in an arterial occlusion (clog). There are over 10 different compounds in arterial plaque, but NO saturated fat. The world’s leading medical journal, and published in the UK, the Lancet, published this finding in 1994.14 Two additional medical journals independently reported--before and after the historic Lancet report-that there is no saturated fat in arterial occlusions.15 Regardless of

“I sincerely hope this article causes you to re-evaluate everything you have been told about EFAs and to consider PEOs as your supplement of choice.” this unequivocal science, the opposite was published and parroted for decades. How many patients were harmed and turned diabetic? Wrong health information given by those who are expected to know medical science, has ruined America and many western countries, turning us into obese diabetics. Don’t let this continue to happen. Relatively little attention has been given to the Parent oils. Nevertheless, there are a number of studies comparing PEOs to the entirely derivative fish oil. The following conclusions are from a sampling of studies involving the physiology and biochemistry of the PEOs: 1. “The reduction in fasting blood glucose and in the glucose area under the curve during the day was significantly greater with the n-6 [from lean fish] than with the n-3 [fatty fish] diet.”16 [Showing 21% less insulin production with fatty fish compared to lean, non-fatty fish containing more PEOs. This should terrify patients, as diabetes has become the #1 epidemic in the world, and fish oil makes it worse]. 2. “n-6 [Parent omega-6] Polyunsaturated fatty acids extend life span through the activation of autophagy.”17 [Emphasis added] 3. “Higher linoleic acid (Parent n-6) was associated with reduced risks of lowgrade and total prostate cancer.”18 [In this landmark study, the men taking the most fish oil had the most prostate cancer!] 4. “Parent omega-3 is significantly lower in patients with dementia and fish oil didn’t help.”19 [If fish oil were to help anywhere, it must help in the brain for this condition, but it failed]. 5. “Wherever we saw fatty streaks (an early state of atherosclerosis), we also found a deficiency in EFAs (Parent Essential Oil’s LA)”.20 [Proof that Parent omega-6 is a significant factor in Cardiovascular Disease.] 6. “In this study, a vegetarian diet was found to sensitize subjects to insulin [an increased-positive response].” 21 [The researchers believed it to be related to a greater proportion of LA (Parent omega-6) in their serum phospholipids.]

Summary Parent Essential Oils (PEOs) should always be used before marine oil or fish oil supplements. Fish oils, because of their steroid-like effect of impairing the immune system, should never be prescribed prophylactically. I sincerely hope this article causes you to re-evaluate everything you have been told about EFAs and to consider PEOs as your supplement of choice.

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Recommended reading

References

The trilogy of Professor Peskin’s landmark books: The PEO Solution by Professor Brian Peskin, BSc-MIT and Robert Rowen, M.D., The Hidden Story of Cancer by Professor Brian Peskin with Amid Habib, M.D., and The 24-Hour Diet with Stephen Cavallino, MD (Italy). (www.Pinnacle-press.com)

1 B. E. Karlstom, et al., “Fatty fish in the diet of patients with type 2 diabetes: comparison of the metabolic effects of foods rich in n-3 and n-6 fatty acids,” American Journal of Clinical Nutrition, vol. 94, no. 1, pp. 26-33, 2011; H. Glauber, et al., “Adverse metabolic effect of omega-3 fatty acids in non-insulin dependent diabetes mellitus,” Annals of Internal Medicine, vol. 108, no. 5, pp. 663-668, 1988; P. W. Stacpoole, et al., “Dose response effects of dietary marine oil on carbohydrate and lipid metabolism in normal subjects and patients with hypertriglyceridemia,” Metabolism, vol. 38, no. 10, pp. 946-956, 1989. 2 Campbell I.M., Crozier D.N., Caton R.B., “Abnormal fatty acid composition and impaired oxygen supply in cystic fibrosis patients,” Pediatrics 1976; 57: 480-486. 3 Alberts, Bruce, et al., Molecular Biology of the Cell, Garland Science, New York, NY, 1994, page 428. 4 Murray, Robert K, et al, Harper’s Illustrated Biochemistry (26th edition), McGraw-Hill, New York, 2003: 97; Guyton, Arthur C & Hall, John E, Textbook of Medical Physiology (9thed.), W.B. Saunders Co. 1996: 16, 861-862. 5 Warburg, Otto, “The Metabolism of Tumors: Investigations from the Kaiser Wilhelm Institute for Biology,” translated by Frank Dickens, Constable & Co Ltd., 1930, page 56 (out of print). Ref: Hoppe-Seylers Zeitschr. f. physiol Chem., 66, 305, 1910. 6 J. C. Umhau, W. Zhou, R. E. Carson, et al., “Imaging Incorporation of Circulating Docosahexaenoic Acid [DHA] into the Human Brain Using Positron Emission Tomography,” Journal of Lipid Research, Vol. 50, No. 7, 2009, pp. 1259-1268. doi:10.1194/jlr. M800530-JLR200

Fish oil fails again and again. Here are 3 key issues to never forget: “Oily” fish (what we are told is best) is WORST

Importance to diabetics: Both fish oil supplements and even “oily fish” itself are highly problematic for diabetics. In 2011, researchers examined the e?ects of fish consumption on Type II diabetic patients. The experiment showed that the diabetics who consumed only non-fatty fish, containing more Parent omega-6 and much less EPA/DHA, had significantly lower blood sugar (good outcome). Further, those who ate “fatty” fish saw a decreased insulin output of 21% (bad outcome) compared to those not eating “fatty” fish.1

Importance to cancer victims: Oily fish and marine oil supplements-contributing to higher blood glucose and insulin levels-exacerbate patients’ existing cancer metabolism and metastatic potential because cancer thrives on high blood glucose levels.2 This effect is the opposite of any treatment’s desired outcome.

Importance to those pursuing maximum anti-aging: Cold-water fish (the type we are told is best) live in temperatures as low as 32º degrees F, but warm-water fish may live in 70º degree F waters and have 14X LESS EPA / DHA content than their cold-water relatives!3 Humans live with body temperatures close to 100º F (98.6ºF). At that temperature, fish oil spontaneously becomes rancid (spoiled). This fact alone should cause tremendous concern. EPA / DHA act as “biological antifreeze” to fish living in frigid waters. Humans don’t require such copious amounts because we have an internal temperature of 98.6º F. 1 B. E. Karlström, et al., “Fatty fish in the diet of patients with type 2 diabetes: comparison of the metabolic e?ects of foods rich in n-3 and n-6 fatty acids,” American Journal of Clinical Nutrition, vol. 94, no. 1, pp. 26-33, 2011. 2 B. S. Peskin and A. Habib, The Hidden Story of Cancer (6th edition), Pinnacle Press, Houston, Texas 2011. 3 K. Gopakumar and M. Rajendranathan Nair, “Fatty acid composition of eight species of Indian marine fish,” Journal of the Science of Food and Agriculture, vol. 23, no. 4, pp. 493-496, 1972.

7 P. L. Goyens, et al., “Conversion of Alpha-Linolenic Acid in Humans Is Influenced by the Absolute Amounts of Alpha- Linolenic Acid and Linoleic Acid in the Diet and Not by Their Ratio,” The American Journal of Clinical Nutrition, 2006, Vol. 84, No. 1, pp. 44-53. 8 N. Hussein, E. et al., “Physiological Compartmental Analysis of Alpha-Linolenic Acid Metabolism in Adult Humans,” Journal of Lipid Research, Vol. 46, 2005, pp. 269-280. doi:10.1194/jlr.M400225-JLR200. 9 Peskin, B.S., Food and Nutrition Sciences, 2013, 4; 9A, 76-85. http://dx.doi.org/10.426/ fns.2013.49A 1013 Published Online September 2013 (www.scirp.org/journal/fns) 10 Peskin, B.S., Food and Nutrition Sciences, 2013, 4, 1128-1144 Published Online November 2013 (http://www.scirp.org/journal/fns) http://dx.doi.org/10.4236/fns.2013.411147 11 From both Dr. Topol’s blog (www.theheart.org/columns/topolog/fish-oils-to-preventchd----it’s-now-official-a-definite-no-go.do) and theheart.org (www.theheart.org/article/1536889.do), accessed May 10, 2013. 12 Spector, A.A., “Plasma Free Fatty Acids and Lipoproteins as Sources of Polyunsaturated Fatty Acid for the Brain,” Journal of Molecular Neuroscience, Vol. 16, 2001: 159165, “Most of the plasma-free fatty acid (EFA) is derived from the triglycerides stored in the adipose tissue [body fat].” [Note: Organs, including the brain, use these EFAs for structural incorporation.]; R.S. Chapkin, et al, “Metabolism of essential fatty acids by human epidermal enzyme preparations: evidence of chain elongation,” Journal of Lipid Research, Volume 27: 954-959, 1986; Markides, M., et al., “Fatty acid composition of brain, retina, and erythrocytes in breast- and formula- fed infants,” The American Journal of Clinical Nutrition, 1994;60:189-94; Agneta Anderson, et al., American Journal of Endocrinological Metabolism, 279: E744-E751. 13 “Fish-oil supplementation reduces stimulation of plasma glucose fluxes during exercise in untrained males,” British Medical Journal of Nutrition (2003), 90, 777-786. 14 Felton, CV, et al., “Dietary polyunsaturated fatty acids and compositions of human aortic plaque,” Lancet; 344:1195-1196, 1994. 15 Waddington, E., et al., “Identification and quantification of unique fatty acid and oxidative products in human atherosclerotic plaque using high-performance lipid chromatography,” Annals of Biochemistry; 292(2):234-244, 2001; Kuhn, H., et al., “Structure elucidation of oxygenated lipids in human atherosclerotic lesions,” Eicosanoids; 5:17- 22, 1992. 16 Karlström, BE, et al., “Fatty fish in the diet of patients with type 2 diabetes: comparison of the metabolic effects of foods rich in n-3 and n-6 faty acids,” Am J Clin Nutr 2011;94:26-33. 17 O’Rourke, Eyleen, J., et al., Genes & Development (2013). Published in advance February 7, 2013, http:// genesdev.cshlp.org/content/27/4/429.full. 18 Brasky, Theodore, M., et al., “Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial,” Journal of the National Cancer Institute, Vol. 105, No. 15, 2013, pp. 1132-1141. 19 Cherubini, A., et al., “Low Plasma N-3 Fatty Acids and Dementia in Older Persons: The InCHIANTI Study, J Gerontol A Biol Sci Med Sci. 2007 October; 62(10): 1120-1126. 20 Das, U.N., “A defect in the activity of D6 and D5 desaturases may be a factor in the initiation and progression of atherosclerosis,” Prostaglandins, Leukotrienes and Essential Fatty Acids, 76 (2007) 251-268. 21 Kahleova, H., et al., “Vegetarian diet-induced increase in linoleic acid in serum phospholipids is associated with improved insulin sensitivity in subjects with type 2 diabetes,” Nutr. Diabetes, 2013 Jun 17;3.

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PEO-Pro 120 Capsules $39.99 Special introductory oﬀer save $5.00 per pack (Until March 1st 2015) *Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

Hydergine

the intelligence ergoloid

How many times have you asked yourself, “Where did I put the keys?” or grapple for words during a “senior moment?” While aging is associated with the impairment of multiple metabolic pathways that can erode brain function, we don’t have to resign ourselves to dwindling memory, foggy thinking, or poor attention span as we grow older. Thankfully, there is something we can do about it. The drug hydergine acts on numerous fronts to slow down or even reverse age-related alterations in brain physiology and improve cognitive function. It’s one of the safest, most effective, and intensively researched smart drugs available today. Over the past few decades, this potent cerebral enhancer has been shown in innumerable animal and clinical studies to boost memory and retrieval, alertness, intellectual capacity and even mood, while fending off the many deleterious processes that can lead to brain aging and mental decline.

By Leslie J Farer

Hydergine (also known as ergoloid mesylates or co-dergocrine mesylate) is the brand name for a mixture of three alkaloids derived from ergot, a fungus that grows on rye. The drug was developed in the 1940’s by Albert Hofmann (known famously as the inventor of LSD) when working as a chemist for Sandoz (now Novartis and coincidentally, a former employer of the author of this article) and is still one of that pharmaceutical giant’s most important drugs. Since the early 1970’s, hydergine has been used clinically to treat senile dementia (including Alzheimer’s), cerebral vascular disorders and the typical progressive deterioration of mental capacity known as age-related cognitive decline. Its efficacy has been well documented. The drug was approved by the FDA in 1981 for the treatment of dementia, defined as a loss of mental ability severe enough to interfere with daily life and characterized by symptoms such as decreased mental alertness, confusion, poor short-term memory, depression, emotional instability and problems related to motor skills. But perhaps the drug has an equally important role when used “off-label” as a smart drug, or cerebral enhancer, in healthy people who wish to protect

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against brain aging, sharpen their wit and mental agility, improve their memory and focus, and even gain a competitive edge in their career or pursuits. It’s interesting to note that Hoffman, who lived to be 102, regularly consumed hydergine as a brain tonic, which may in part be responsible for his longevity and brain power.

Research supporting the cognitive effects of hydergine in animals and humans In animal models, patients with cognitive decline, and aging but otherwise healthy people, hydergine has been shown to improve measures of cerebral function such as learning, memory, attention, as well as mood. Animal studies typically use a maze, or similar apparatus, as a “paradigm” for assessing cognitive behavior. One such study showed that hydergine increased the “intelligence” of rats trained in a maze to receive a liquid reward, as evidenced by increased accuracy in their attempts to obtain the treat. (1) In a similar maze experiment, hydergine improved memory and retrieval processing in mice, with the typical “inverted U” dose-response curve characteristic of memory enhancers. (2) (We’ll see more on the inverted U curve later.) In clinical studies, hydergine was well tolerated in virtually every study, and often demonstrated statistically significant effects on cognitive measures in healthy subjects exhibiting “normal” aging and in patients with more accelerated cognitive decline. Here are some highlights of the studies, (note; the latter four were placebo-controlled and the first three were double-blind; they are listed in order of clinical severity, from the most to the least mental impairment): • A trial on 36 patients with severe dementia found that daily intravenous (IV) hydergine (3 mg) for two weeks significantly improved cognitive dysfunction, mood and social withdrawal. (3) • As in the above study, improvements in mental deficits were demonstrated in 97 elderly patients with age-related mental decline who were administered 4.5 mg hydergine tablets for 6 months; the researchers observed a progressive increase in efficacy throughout the course of the trial, indicating that treatment in patients with mental decline should be long-term. (4) • In a trial on 41 outpatients between the ages of 55 to 80 who were otherwise healthy, but experiencing mild memory impairment (a common complaint for the general aging population), a 6 mg daily oral dose of hydergine for 12 weeks considerably improved memory function. (5) • A fascinating and revealing study of the effects of hydergine on a subset of the healthy but aging population was performed on over 100 disease-free retirees for five years. This was an unusual study on two counts: it evaluated the effects of a drug on healthy, rather than impaired subjects, and it was longterm. The study authors observed that retirees receiving 4.5 mg hydergine per day for the length of the study exhibited not only better mental performance than those on placebo, but also enhanced physical health, as evidenced by factors such as lowered lipid fractions and fewer diagnoses of major disease. The authors went on to say that although they felt that each individual improvement in and of itself was not 14

dramatic, overall, the combined positive effects pointed to the “prophylactic effect of ergoloid mesylates [hydergine] on the pathological concomitants of aging.” (6) In other words, hydergine protects against multiple aspects of age-related physical and mental decline – an impressive conclusion.

Hydergine acts by diverse mechanisms to enhance brain function We’ve just seen the proven cognitive-boosting effects of hydergine in animals and humans. Now, let’s take a look at the aging brain, and discuss how hydergine counteracts eroding mental performance. The brain is especially vulnerable to the effects of aging on numerous fronts: decreased blood and oxygen flow, diminished mitochondrial energy production, hindered neurotransmission, loss of structural integrity, oxidative damage and decreased neuronal activity. Each of these factors alone impairs mental function; in combination, as is often (if not always) the case, the effects can be disastrous. The good news is that hydergine has been shown to influence many aspects of brain metabolism and ameliorate all of the effects of aging we just mentioned. Early research showed that hydergine acted primarily by increasing blood supply and oxygen to the brain, but a plethora of brain-boosting mechanisms have since been discovered: • Hydergine enhances neuronal metabolism: In middle-aged rats, hydergine stimulates local cerebral glucose utilization in parts of the brain associated with learning and memory, (7) and the same effect has been found in patients with dementia. (8) Glucose is the main substrate for brain metabolism, (8) and measurements of increased cerebral glucose utilization in response to hydergine indicate enhanced neuronal activity. Hydergine was also shown to stimulate neuronal functioning in short-lived (i.e., rapidly aging) mice. (9) In addition, hydergine preserves neuronal ATP stores. (10) ATP (adenosine tri-phosphate) is the cellular energy currency crucial to metabolism. (We’ll see below how hydergine reverses age-related changes in mitochondria, the ATP-generating cellular powerhouses.) • Hydergine modulates neurotransmission in several ways: First, hydergine decreases levels of the monoamine oxidase (MAO) enzymes in the brain. (11-12) MAO enzymes degrade used neurotransmitters and are essential to normal brain metabolism, but an age-related increase in MAO activity can deplete the catecholamine neurotransmitters (dopamine, noradrenaline, and adrenaline), (11-12) impairing mental function. Hydergine counteracts this effect. Second, hydergine regulates the release of the neurotransmitter acetylcholine from the hippocampus, (13) the part of the brain that helps transfer information from short-term to long-term memory. The drug also increases the number of cholinergic (acetylcholine) receptors in the aging hippocampus; (14-15) a decline in the number of cholinergic receptors can lead to a decrease in learning ability and memory function, (14-15) and hydergine can at least partially reverse these effects. Another characteristic of brain aging is a deficiency in enzymes

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necessary for the synthesis of acetylcholine. In aged rats and mice, treatment with hydergine restored the activity of one of these enzymes, choline acetyltransferase. (16) Third, hydergine prevents disturbances in monoamine (dopamine, noradrenaline and serotonin) neurotransmission in different areas of the brain: it can either compensate for a neurotransmitter deficit or counteract its over-activity, (17-18) restoring balance in the interaction of the monoamines. (10) • Hydergine protects the brain against hypoxia: Hydergine can prevent mental impairment and physical damage to the brain caused by insufficient oxygen reaching the brain (hypoxia). In a placebo-controlled trial, 15 healthy volunteers inhaled a gas combination simulating high altitude conditions (6000 m altitude), which induced hypoxia and resulted in decreased vigilance, intellectual function and performance in a reaction time task. But after oral administration of 5 mg hydergine, volunteers again subjected to the same conditions exhibited significant protection against hypoxia-induced brain dysfunction. (19) Because of its neuroprotective effects, hydergine is used in emergencies to treat strokes or accidents that interrupt oxygen supply to the brain. • Hydergine slows down age-related structural changes in the brain: Aging is associated with the loss of structural integrity of parts of the brain, which can negatively affect cognition. Two of these components are mossy fibers, (nerve fibers that surround nerve cells of the cerebellar cortex) and granule cells (a type of neuron). (20) In rats, medication with hydergine increased the density of mossy fibers and the number of granule cells in the hippocampus. (20) The aging brain has also been shown to undergo a loss of synapses, (21-22, 10) the gaps between neurons where nerve impulses are transmitted. But hydergine reverses this loss: four weeks of hydergine treatment significantly increased the number of synapses in the brains of old rats, compared to untreated rats. (22) • Hydergine fights lipofuscin: Lipofuscin is the yellow-brownish colored pigments--oxidation products--that accumulate in cells (including neurons) over time. In old rats, six months of hydergine treatment caused a significant dose-related decrease in lipofuscin accumulation in various types of nerve cells. (23) • Hydergine enhances antioxidant status: Free radical damage is involved in many, if not all, age-related disease processes, including dementia and cognitive decline. (12) One generator of free radicals in the brain is the increased activity of MAO (12) that accompanies aging. As discussed earlier, hydergine suppresses MAO over-activity, which, besides preserving neurotransmitters, leads to a reduction in oxidative stress. (12) Hydergine further counters free radicals by increasing the endogenous antioxidants superoxide dismutase (SOD) and catalase (CAT) in the brain. (12) • Hydergine reverses age-related mitochondrial alterations: Mitochondria are tiny but extremely important organelles (cellular subunits), the machinery necessary for the production

of energy (ATP). Aging is associated with yet another example of deterioration--the loss in number and metabolic efficiency of these crucial organelles. (10) Nerve cells, especially at their synaptic ends, need a high and steady energy supply, generated by their mitochondria, to carry out their job of cell-to-cell information processing in an efficient manner. Any impairment in mitochondrial activity can lead to a “power failure” situation in which insufficient energy is available to run the brain’s circuits, with adverse effects on mental functioning. In a noteworthy study, a group of researchers examined the structural features of mitochondria specifically located at nerve cell terminals at the synaptic gap, in young, adult, and old rats. They found age-related differences in the mitochondria of older versus younger rats. The old rats exhibited fewer but larger (i.e., elongated) mitochondria compared with younger rats, in which smaller and more numerous mitochondria were equated with greater ATPgenerating capacity. So, in the old rats, the few enlarged organelles were an indication that the cellular machinery struggled to keep up with energy-dependent synaptic activity, especially in high-demand circumstances. But four weeks of hydergine treatment (at an ultra-high dose) partially reversed these alterations in old rats, as shown by an increase in number and a reduction in size of the mitochondria, indicating improved metabolic efficiency more comparable to the younger animals. (10) This list of varied mechanisms underlies the efficacy of hydergine in ameliorating and potentially reversing, agerelated brain deterioration and improving cognitive function. Plus, this list is not exhaustive. Undoubtedly, on-going research will uncover additional beneficial effects of this powerful cerebral enhancer.

Some researchers cast doubt? Even with the wealth of compelling findings obtained in dozens of animal and human trials, some researchers questioned hydergine’s efficacy in treating advanced cognitive decline, (i.e., dementia, including Alzheimer’s). In response to this uncertainty, meta-analyses were performed to statistically evaluate the data obtained in multiple human trials. Two of these overviews, (one evaluating 21 trials and another analyzing 47 trials) concluded that “hydergine shows significant treatment effects” especially when initiated early and at higher doses than the FDA-approved 3 mg dose. (24-25) One reason why some trials reported only modest improvements in hydergine-treated patients is simply that the dose used was too low and therefore, ineffective. In Europe, the drug is prescribed at doses of at least 9 mg per day, but in the US, the recommended starting point is 3 mg. Since the drug

“Maintaining a healthy brain as we grow older, rather than rescuing cognition later, is a key component of an effective longevity strategy.”

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exhibits low, if any, toxicity, and higher quantities have been linked with greater efficacy, it seems counterproductive (and unscientific) to use the lower dose.

Curr Med Res Opin. 1986;10(4):256-79.

The four clinical studies we reviewed earlier, in which significant improvements were obtained, used oral doses of 4.5 mg to 6 mg and an IV dose of 3 mg (note that a 3 mg IV dose has far greater potency than a 3 mg oral dose; directly injecting a drug into the bloodstream markedly increases its bioavailability). Also, unfavorable results in some trials may be due to the fact that treatment was initiated too late in the progression of cognitive decline. This indicates that medication with hydergine should be started as early as possible in those experiencing the first signs of mental deterioration, since treatment may prevent the cascade of brain alterations that can lead to more advanced cognitive decline and Alzheimer’s.

8. Nagasawa H(1), Kogure K, Kawashima K, Ido T, Itoh M, Hatazawa J. Effects of co-dergocrine mesylate (Hydergine) in multi-infarct dementia as evaluated by positron emission tomography. Tohoku J Exp Med. 1990 Nov;162(3):225-33.

Maintaining a healthy brain as we grow older, rather than rescuing cognition later, is a key component of an effective longevity strategy.

More on dosing − how to use hydergine It’s difficult to recommend a universal starting dose for everyone, since response depends on each person’s unique physiology, sensitivity to medications and cognitive status. If used alone, you may consider starting with half of a 4.5 mg tablet for a few days, note your response, then increase to a full tablet, again rate your response and increase as necessary. Also, keep in mind that hydergine exhibits an inverted-U dose-response curve, which means that the dose should be increased slowly to reach an ideal response, after which any further increase in dose may lead to a fall-off in effect. Hydergine may also be combined with other smart drugs, such as deprenyl or piracetam, where it acts synergistically (i.e., at higher potency, while enhancing the effects of these other agents), so dosages may need to be adjusted down. As with other smart drugs, the best advice is to start low, increase gradually, evaluate the effect, and fine-tune as necessary. Whether used alone, or in combination, hydergine should be a central element of any comprehensive antiaging program to preserve brain health, boost cognitive function and defend against the potentially devastating effects of age-related mental decline. References 1. Jaton AL, Vigouret JM. Effects of Hydergine and its components on Lashley maze acquisition in rats. J Pharmacol. 1985;16 Suppl 3:51-6. 2. Flood JF, Smith GE, Cherkin A. Hydergine enhances memory in mice. J Pharmacol. 1985;16 Suppl 3:39-49. 3. Arrigo A, Casale R, Giorgi I, Guarnaschelli C, Zelaschi F. Effects of intravenous high dose co-dergocrine mesylate (‘Hydergine’) in elderly patients with severe multi-infarct dementia: a double-blind, placebocontrolled trial. Curr Med Res Opin. 1989;11(8):491-500.

7. Walovitch RC, Ingram DK, Spangler EL, London ED. Co-dergocrine, cerebral glucose utilization and maze performance in middle-aged rats. Pharmacol Biochem Behav. 1987 Jan;26(1):95-101.

9. Serino A, Kan K, Graves K, Kule C, Anthony A. Age, strain, and semichronic hydergine treatment effects on motor activity and neuronal nucleic acid-protein metabolism in male mice. Life Sci. 2000 Aug 11;67(12):1489-505. 10. Bertoni-Freddari C, Fattoretti P, Casoli T, Spagna C, Meier-Ruge W. Morphological alterations of synaptic mitochondria during aging. The effect of Hydergine treatment. Ann N Y Acad Sci. 1994 Jun 30;717:137-49. 11. Büyüköztürk A, Kanit L, Ersöz B, Menteş G, Hariri NI. The effects of hydergine on the MAO activity of the aged and adult rat brain. Eur Neuropsychopharmacol. 1995 Dec;5(4):527-9. 12. Sözmen EY, Kanit L, Kutay FZ, Hariri NI. Possible supportive effects of co-dergocrine mesylate on antioxidant enzyme systems in aged rat brain. Eur Neuropsychopharmacol. 1998 Feb;8(1):13-6. 13. Imperato A, Obinu MC, Dazzi L, et al. Co-dergocrine (Hydergine) regulates striatal and hippocampal acetylcholine release through D2 receptors. Neuroreport. 1994 Feb 24;5(6):674-6. 14. Amenta F, Cavallotti C, Franch F, Ricci A. Muscarinic cholinergic receptors in the hippocampus of the aged rat: effects of long-term hydergine administration. Arch Int Pharmacodyn Ther. 1989 Jan-Feb;297:225-34. 15. Le Poncin-Lafitte M, Rapin JR, Duterte D, Galiez V, Lamproglou I. Learning and cholinergic neurotransmission in old animals: the effect of Hydergine. J Pharmacol. 1985;16 Suppl 3:57-63. 16. Dravid AR, Hiestand P. Deficits in cholinergic enzyme activities in septo-temporal regions of the senescent rat hippocampus, and in the forebrain of aged mice: effect of chronic Hydergine treatment. J Pharmacol. 1985;16 Suppl 3:25-32. 17. Wadworth AN, Chrisp P. Co-dergocrine mesylate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in age-related cognitive decline. Drugs Aging. 1992 May-Jun;2(3):153-73. 18. Markstein R. Hydergine: interaction with the neurotransmitter systems in the central nervous system. J Pharmacol. 1985;16 Suppl 3:1-17. 19. Saletu B, Grünberger J, Anderer R. On brain protection of co-dergocrine mesylate (Hydergine) against hypoxic hypoxidosis of different severity: double-blind placebo-controlled quantitative EEG and psychometric studies. Int J Clin Pharmacol Ther Toxicol. 1990 Dec;28(12):510-24. 20. Amenta F, Jaton AL, Ricci A. Effect of long term hydergine treatment on the age-dependent loss of mossy fibers and of granule cells in the rat hippocampus. Arch Gerontol Geriatr. 1990 May-Jun;10(3):287-96. 21. Masliah E(1), Crews L, Hansen L. Synaptic remodeling during aging and in Alzheimer’s disease. J Alzheimers Dis. 2006;9(3 Suppl):91-9. 22. Bertoni-Freddari C, Giuli C, Pieri C, et al. J Gerontol. The effect of chronic hydergine treatment on the plasticity of synaptic junctions in the dentate gyrus of aged rats. 1987 Sep;42(5):482-6. 23. Amenta D, Ferrante F, Franch F, Amenta F. Effects of long-term Hydergine administration on lipofuscin accumulation in senescent rat brain. Gerontology. 1988;34(5-6):250-6. 24. Olin J, Schneider L, Novit A, Luczak S. Hydergine for dementia. Cochrane Database Syst Rev. 2001;(2):CD000359. 25. Schneider LS, Olin JT. Overview of clinical trials of hydergine in dementia. Arch Neurol. 1994 Aug;51(8):787-98.

4. Rouy JM, Douillon AM, Compan B, Wolmark Y. Ergoloid mesylates (‘Hydergine’) in the treatment of mental deterioration in the elderly: a 6-month double-blind, placebo-controlled trial. Curr Med Res Opin. 1989;11(6):380-9. 5. Thienhaus OJ, Wheeler BG, Simon S, Zemlan FP, Hartford JT. A controlled double-blind study of high-dose dihydroergotoxine mesylate (Hydergine) in mild dementia. J Am Geriatr Soc. 1987 Mar;35(3):219-23. 6. Huber F, Köberle S, Prestele H, Spiegel R. Effects of long-term ergoloid mesylates (‘Hydergine’) administration in healthy pensioners: 5-year results.

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Dr Ward Dean answers your questions

We are delighted that Ward Dean, M.D., one of the world’s foremost antiaging physicians, has agreed to answer our readers’ questions. Full details about Dr. Dean can be seen at his website: www.warddeanmd.com

Q. My 18-year old son has been diagnosed with ADHD, he has not been prescribed anything yet- but I have heard bad things about amphetamine drugs like Ritalin®. I would greatly appreciate your advice on better medicines and nutrition that could help him instead? Thank you very much. A.S., Arizona

A. Dear Mrs. A.S., Stimulants like Ritalin® are effective in controlling the symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD). Unfortunately, they are, of course, addictive Schedule II controlled substances, with side effects of their own—and are ineffective in about 30% of users. Fortunately, there are a number of other medications and natural substances that address the cause of his condition and may enable your son to avoid psycho-stimulants like Ritalin and Adderall®.

• Relieved lassitude and mild depression with obvious letdown when it was discontinued • Was useful in schizophrenia of long duration (with prolonged treatment) • Decreased irritability and reduced over-activity, leading to a much better overall social adaptation and improved scholastic functioning • Increased attention span • Did not cause drowsiness • Improved IQ!

Furthermore, he found that DMAE had numerous advantages over the amphetamines (like Ritalin) in that there were no effects on heart rate or blood pressure, and no induced jitteriness. Instead of causing anorexia (loss of appetite) like the amphetamines, he found that DMAE actually improved appetite in many patients and caused no interference with sleep. In fact, he reported DMAE or centrophenoxine that DMAE actually reduced sleep requirements. Dr. Oettinger concluded that; “DMAE was a most useful tool For children (and adults) who suffer from ADHD in the handling of children with behavioral problems.” (and even for those who don’t), I recommend DMAE (1) In 1960, Dr. Stanley Geller conducted a double-blind (dimethylaminoethanol). DMAE has been used for over half a century to improve behavioral disorders in children, study of seventy-five children. DMAE in doses of 50 mg twice daily resulted in improved functioning capacity, and may have positive effects on intelligence and grades puzzle-solving ability and organizational activity. (2) as well. In 1958, Dr. Leon Oettinger, Jr., reported that Another double-blind study compared DMAE with both DMAE: methylphenidate (Ritalin®) and placebo in seventy-four • Accelerated mental processes children with unspecified “learning disabilities” (what • Improved concentration span we would probably call ADHD today). The study found significant test score improvement for both treatment • Abolished early morning fogginess 18

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groups over a 10-week period. (3) In another doublestudied. One of the first studies for ADHD compared blind study of fifty children with “hyperkinetic syndrome,” modafinil (200 mg/day) with amphetamine and placebo DMAE was administered in doses up to 500 mg/day. The in twenty-two adults. Modafinil and amphetamines author concluded that DMAE, at doses of 300-500 mg per were both found to improve ADHD behavior.(11) In a day for 12 weeks to moderately disturbed hyperkinetic continuing series of studies, modafinil improved ADHD children produced greater overall improvement compared symptoms in eleven children on average doses of 200 mg/ to patients treated with a placebo. (4) Although human day (range 100–400 mg);(12) twenty-two children studies were rare after the late 70s, due to DMAE’s loss with ADHD, taking modafinil in doses ranging from of patent protection, more recent studies have confirmed 200–300 mg /day, exhibited greater improvement than its benefits and mechanisms. A 1995 study from the placebo group;(13) twenty adults with ADHD on Duke University found that rats given DMAE showed modafinil 200 mg showed enhanced performance on a improvements in their working memory performance, number of standard psychological tests; (14) 164 children (5) and a more recent study from 2003 involved eighty and adolescents with ADHD, taking 270 mg of modafinil/ students with “borderline emotional disturbance.” The day (range 170–425 mg), showed greater improvements subjects were given either a placebo or a vitamin/mineral than the placebo-treated group. (The differences in mixture which contained DMAE bitartrate. The subjects symptoms were apparent from the first week of treatment taking the vitamin/mineral/DMAE mixture had a greater and were maintained throughout the study);(15) another increase in well-being and improvement in mood and large study of childhood ADHD (100 in the modafinilattention compared to those taking the placebo. (6) treated group and 41 in the placebo group), with an average dose of 360 mg modafinil, again demonstrated Centrophenoxine (Lucidril®, Centro-Pro™, reduced ADHD symptoms at school and home;(16) 223 meclofenoxane) was developed in 1959, and has children (aged 6–13 years) receiving modafinil showed been called a “brain metabolic stimulant” and a a greater improvement in all three of the major ADHD neuroenergizer). (7) Scientists from India declared rating scales; (17) and 190 ADHD patients (aged 6–17 it to be a neurorejuvenator. (8) Centrophenoxine years) showed greater improvement in the modafinilstimulates glucose uptake, oxygen consumption, and treated groups (receiving either 340 mg or 425 mg, based cerebral electrical activity in the brain. Increased on body weight) than placebo (18). In a summary brain metabolic and electrical activities are the basis review of modafinil use in ADHD, scientists from the for improved attention and alertness. Clinical studies Department of Psychiatry, University of California, San with centrophenoxine in patients with confusion and disturbances of memory and concentration markedly improved after several weeks of treatment. Studies in “...the strongest evidence among Europe reported significant improvement of fatigue, off-label uses exists for ...Modafinil in irritability, confusion and memory dysfunction with centrophenoxine. (9) Centrophenoxine is a combination attention-deficit disorder.” of DMAE and PCPA (paarachlorophenoxyacetic acid). Pharmacokinetic studies revealed that much higher levels Diego, reviewed 33 double-blind placebo controlled trials of DMAE were found in the brain after centrophenoxine of modafinil, in addition to numerous smaller studies treatment compared to DMAE alone, since the DMAE and case reports. They concluded that “Modafinil is a with PCPA penetrates the blood-brain barrier much promising drug with a large potential for many uses in easier. (10) Centrophenoxine is, in effect, a super-DMAE. psychiatry and general medicine,” and that “the strongest Thus, centrophenoxine can be expected to provide even evidence among off-label uses exists for the use of better results in improving attention. Centrophenoxine Modafinil in attention-deficit disorder.”(19) doses are typically 250–1,000 mg twice daily (breakfast Note: An earlier version of modafinil is adrafinil (Adra-Pro™) it isn’t and lunch). For use in enhancing focus and attention quite as effective as modafinil and can have more side effects; however it span, where no major brain pathology is present, 250 mg is still very effective and considerably cheaper than modafinil. A typical once or twice daily is a generally safe and useful dose. adrafinil dose could be 300 mg once or twice daily, although it is not

Modafinil

recommended to use continuously for 3-months without monitoring liver enzyme levels.

The alerting drug modafinil shares many apparent similarities with amphetamines, (although with fewer adverse side effects and less potential for addiction or abuse). Also, because of modafinil’s effects on cognition, its efficacy in treating ADHD has been extensively

Vitamins B6, D, and magnesium Nutritional supplements may also be of help—especially magnesium, and Vitamins D and B6. Fifty hyperactive children (ages 7-12) were all found to be deficient in

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magnesium (determined by serum and intracellular erythrocyte levels; and hair analysis with atomic absorption spectroscopy). 30 were treated with 200 mg magnesium/day for six months. Twenty were treated with a placebo. Those treated with magnesium experienced normalization of magnesium and decreased hyperactivity, compared to their previous clinical state and to the control group. (20) In a more recent study, 36 children with ADHD who were also low in erythrocyte magnesium levels compared to normal (control) children were treated with 200 mg magnesium and 20 mg vitamin B6 each day for 8 weeks. The authors reported a significant increase in erythrocyte magnesium levels, and significantly improved behavioral and school attention symptoms. (21) Two very recent studies examined Vitamin D levels in students with ADHD, and found those with ADHD to have dramatically lower blood levels than the normal students. (22, 23)

Herbs for ADHD; Ginkgo biloba, ginseng and pycnogenol Because ginkgo biloba has been traditionally used in the treatment of dementia and memory impairment, scientists hypothesized that it might be beneficial for

“Korean red ginseng may be effective in improving inattentiveness in those with ADHD...” those with ADHD. In a double blind comparison of ginkgo and methylphenidate (Ritalin®), fifty students with ADHD (39 boys and 11 girls) were treated with 80-120 mg/day gingko or 20-30 mg/day methylphenidate, (based on subjects’ weight) for a 6 week double blind trial. Although ginkgo was more effective than placebo, it was less effective than methylphenidate in the treatment of ADHD. (24) A year later, an Italian scientist administered ginkgo to six patients with ADD. The author noted significant improvement in hyperactivity, inattention, and immaturity factors and concluded that ginkgo might be a beneficial and useful treatment of ADD, with minimal side effects. (25) In Korea, scientists investigated the effects of Korean red ginseng on ADHD. Eighteen students were administered 1,000 mg of ginseng twice daily for eight weeks. At the conclusion of the study, significant improvements were noted in all rating scales. The authors concluded that; “Korean red ginseng may be effective in improving inattentiveness in those with ADHD.”(26) In 2001, Canadian scientists presciently studied the effects of a combination of ginkgo biloba extract and American ginseng on ADHD. 20

Curiously, they used only 200 mg of American ginseng and 50 mg of ginkgo biloba extract twice daily. Despite these pathetically low doses, they found dramatic improvements in the three ADHD rating scales used. The authors concluded that the ginkgo-ginseng combination may improve symptoms of ADHD. (27) I believe the results would have been even more dramatic if optimum dosages (1,000 mg of ginseng, and 120 mg of ginkgo, each twice daily) had been used. Pycnogenol® is the trade name for French maritime pine bark extract; Pycnogenol acts as a vasodilator, which improves cerebral blood flow to brain regions involved in ADHD, (28) and regulates catecholamine levels among ADHD children. (29) In a study to evaluate the effect of Pycnogenol on ADHD symptoms, sixty-one children with ADHD were supplemented with 1 mg/kg/day Pycnogenol or placebo over a period of 4 weeks. Pycnogenol administration caused a significant reduction of hyperactivity, improved attention, and improvement of fine motor coordination and concentration of children. (29)

Lead, cell phones, and chelation Lead intoxication has been strongly associated with ADHD. Blood lead above 10 μg/dL had been reliably associated with ADHD and related behaviors--the only real dispute was to determine if there was a safe level of lead. (30-32) Subsequent studies indicated that even very low levels of blood lead (2-10 μg/dL) are associated with ADHD. (33-35) In 2013, a team of Korean scientists conducted a large, (nearly 2,500 students) 2 year-long study and found that simultaneous exposure to lead and RF from mobile phone use was associated with increased ADHD symptom risk.(36) I recommend that those with ADHD minimize the use of cellphones and undergo oral and/or IV chelation therapy with EDTA. [Ed.- EDTA is available in BCI®, EDD® and also in Beyond Clean2® bath salts].

Conclusion: To sum everything up, I recommend appropriate doses of DMAE or Centrophenoxine; if your budget allows, modafinil 100 mg in the morning, and another 100 mg in early afternoon; (alternatively the adrafinil), magnesium 200-400 mg per day (or to bowel tolerance—excessive magnesium will cause GI upset or diarrhea); Vitamin D3 5,000 IU/day; Vitamin B6 200 mg/day; Ginseng 1,000 mg twice daily; Ginkgo biloba 120 mg twice daily and Pycnogenol 50-100 mg/day. I suggest starting with one supplement at a time, adjust the dose to your son’s response/tolerance and then introduce other supplements sequentially (If he starts with everything all at once, it will be difficult to identify what is working, or what is causing an adverse side effect, (although side effects with any of

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these substances are neither serious nor common). Finally, because of the adverse effects of any amount of lead, I again recommend oral and/or IV chelation therapy with EDTA and based on the conclusive results from the Korean scientists, I recommend minimal use of cellphones, and use of various shielding devices to minimize microwave exposure such as RF-blocking protective cases and air-tube headsets.

Ward Dean, M.D.

20. Ballon JS, Feifel D. A systematic review of modafinil: Potential clinical uses and mechanisms of action. J Clin Psychiatry. 2006;67(4):554-66. 21. Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnes Res. 1997 Jun;10(2):149-56. 22. Mousain-Bosc M, Roche M, Polge A, et al. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders. Magnes Res. 2006 Mar;19(1):46-52. 23. Kamal M, Bener A, Ehlayel MS. Is high prevalence of vitamin D deficiency a correlate for attention deficit hyperactivity disorder? Atten Defic Hyperact Disord. 2014 Jun;6(2):73-8. doi: 10.1007/s12402-014-0130-5. Epub 2014 Mar 9. 24. Goksugur SB, Tufan AE, Semiz M, et al. Vitamin D status in children with attention-deficit-hyperactivity disorder. Pediatr Int. 2014 Aug;56(4):515-9. doi: 10.1111/ped.12286. Epub 2014 Jun 17.

References 1. Oettinger, L. The use of Deanol in the treatment of disorders of behavior in children. J. Pediat, 1958, 53: 761-675. 2. Geller, S. J. Comparison of a tranquilizer and a psychic energizer. JAMA, 1960, 174: 89-92. 3. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther. 1975 May;17(5):534-40. 4. Coleman, N., Dexheimer, P., Dimascio, A., Redman, W., and Finnerty, R. Deanol in the treatment of hyperkinetic children. Psychosomatics, 1976, 17: 68-72. 5. Levin ED, Rose JE, Abood L. Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze. Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):369-73. 6. Dimpfel W, Wedekind W, Keplinger I. Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states. Eur J Med Res. 2003 May 30;8(5):183-91. 7. South, J. “Lucidril- The Anti-Aging Neuro-Energizer.” IAS Anti-Aging Bulletin. 2001 4(9), 31-39. 8. Sharma D, Maurya, AK, and Singh, R. Age-related decline in multiple unit action potentials of CA3 Region of Rat hippocampus: Correlation with lipid peroxidation and liposfuscin concentration and the effect of centrophenoxine. Neurobiology of Aging, 1993, 14:319-330. 9. Zs.-Nagy, I. “A Survey of the Available Data on a New Nootropic Drug, BCE001″ Ann NY Acad Sci. 1994. 717, 102-14. 10. Nandy, K. (1978) “Centrophenoxine: Effects on Aging Mammalian Brain” J Am Ger Soc 26, 74-81. 11. Taylor FB, Russo J. Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults. J Child Adolesc Psychopharmacol. 2000 Winter;10(4):311-20. 12. Rugino TA, Copley TC. Effects of modafinil in children with attention-deficit/ hyperactivity disorder: an open-label study. J Am Acad Child Adolesc Psychiatry. 2001;40 :230– 235 13. CrossRefMedlineWeb of Science 14. Rugino TA, Samsock TC. Modafinil in children with attention-deficit hyperactivity disorder. Pediatr Neurol. 2003; 29 :136– 142 CrossRefMedlineWeb of Science 15. Turner DC, Clark L, Dowson J, Robbins TW, Sahakian BJ. Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder. Biol Psychiatry 2004; 55: 1031–1040. 16. Biederman J, Swanson JM, Wigal SB, et al. Efficacy and safety of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, flexible-dose study. Pediatrics. 2005; Dec;116(6):e777-84.

25. Salehi B, Imani R, Mohammadi MR, et al. Ginkgo biloba for attention-deficit/ hyperactivity disorder in children and adolescents: a double blind, randomized controlled trial. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):7680. doi: 10.1016/j.pnpbp.2009.09.026. Epub 2009 Oct 5. 26. Niederhofer H. Ginkgo biloba treating patients with attention-deficit disorder. Phytother Res. 2010 Jan;24(1):26-7. doi: 10.1002/ptr.2854. 27. Lee SH, Park WS, and Lim MH. Clinical Effects of Korean Red Ginseng on Attention Deficit Hyperactivity Disorder in Children: An Observational Study. J Ginseng Res. Jun 2011; 35(2): 226–234. doi: 10.5142/jgr.2011.35.2.226 28. Lyon MR, Cline JC, Totosy de Zepetnek J, et al. Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. J Psychiatry Neurosci. May 2001; 26(3): 221–228. 29. Rucklidge JJ, Johnstone J, Kaplan BJ. Nutrient supplementation approaches in the treatment of ADHD. Expert Review of Neurotherapeutics. 2009;9(4):461–476. 30. Trebatická J, Kopasová S, Hradecná Z, et al. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur Child Adolesc Psychiatry. 2006 Sep;15(6):329-35. Epub 2006 May 13. 31. Silva PA, Hughes P, Williams S, Faed JM. Blood lead, intelligence, reading attainment, and behaviour in eleven year old children in Dunedin, New Zealand. Journal of Child Psychology and Psychiatry. 1988;29:43–52. 32. Thomson GO, Raab GM, Hepburn WS, Hunter R, Fulton M, Laxen DP. Bloodlead levels and children’s behavior results from the Edinburg Lead Study. Journal of Child Psychology and Psychiatry. 1989;30:515–528. 33. Burns JM, Baghurst PA, Sawyer MG, McMichael AJ, Tong S. Lifetime lowlevel exposure to environmental lead and children’s emotional and behavioral development at 11–13 years: The Port Pirie Cohort Study. American Journal of Epidemiology. 1999;149:740–749. 34. Braun J, Kahn RS, Froehlich T, Auinger P, Lanphear BP. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environmental Health Perspective. 2006;114:1904–1909. 35. Nigg JT, Knottnerus GM, Martel MM, Nikolas M, Cavanagh K, Karmaus W, Rappley MD. Low blood lead levels associated with clinically diagnosed attentiondeficit/hyperactivity disorder and mediated by weak cognitive control. Biological Psychiatry. 2008;63:325–331. 36. Nigg, JT, Nikolas MA, Knottnerus,GM, et al. Confirmation and Extension of Association of Blood Lead with Attention-Deficit/Hyperactivity Disorder (ADHD) and ADHD Symptom Domains at Population-Typical Exposure Levels. J Child Psychol Psychiatry. Jan 2010; 51(1): 58–65. doi: 10.1111/j.1469-7610.2009.02135.x 37. Byun YH, Ha M, Kwon HJ, et al. Mobile phone use, blood lead levels, and attention deficit hyperactivity symptoms in children: a longitudinal study. PLoS One. 2013;8(3):e59742. doi: 10.1371/journal.pone.0059742. Epub 2013 Mar 21.

17. Greenhill LL, Biederman J, Boellner SW, Rugino TA, Sangal RB, Earl CQ et al (2006). A randomized, double-blind, placebo-controlled study of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 45: 503–511. 18. Biederman J, Swanson JM, Wigal SB, Boellner SW, Earl CQ, Lopez FA (2006). A comparison of once-daily and divided doses of modafinil in children with attention-deficit/hyperactivity disorder: a randomized, double-blind, and placebocontrolled study. J Clin Psychiatry 67: 727–735. 19. Swanson JM, Greenhill LL, Lopez FA, Sedillo A, Earl CQ, Jiang JG et al. Modafinil film-coated tablets in children and adolescents with attention-deficit/ hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation. J Clin Psychiatry 2006;67: 137–147.

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Centrophenoxine *Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

The Smarter Way to Combat Mental Decline

CentroPro™ $24.99 each ($5.00 off) Centrophenoxine is a Nootropic or smart drug proven to increase brain power, improve longevity and create an overall sense of mental alertness. Centrophenoxine ‘cleans out’ Lipofuscin the build-up of plaques in the brain, heart, lung and skin cells that accumulates over a lifetime, improving their function and their longevity. Pioneering Centrophenoxine researcher Imre Zs Nagy uses our Cent Pro, so if you want the experts choice you need our Centrophenoxine.

glycosylation and mitochondrial decline.

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UPDATE: ACF228 is now also available in a specially designed mouth inhaler. The ACF228 Breathe-Easy can help those worried about their lung capacity and function, to help protect against oxygen deprivation and hopefully avoid the need for long term use of corticosteroids. In addition to the original ACF228 formula it also contains glutathione.

For further details about ACF228 and much more besides we recommend Dr. Lippman’s latest book ‘Stay 40.’

1st Line™ (thiocyanate) 1st Line is an exciting new and all natural weapon in the fight against various types of infections including viruses. 1st Line contains a patented formula that when made up with water becomes a drink that contains thiocyanate ions.

Adrafinil (Olmifon®)

Thiocyanate ions (also known as oxythiocyanate) are the same molecules made in body’s airways and passages, for example they can be found in tears, saliva and milk and they literally form the body’s first line of defence against all types of bacteria, yeasts, fungi, flukes, germs and even viruses, helping to destroy them on contact. Consuming 1st Line helps to flood the bloodstream with thiocyanates, but unlike antibiotics 1st Line does not attack self-molecules, in other words beneficial floras are not disturbed. Clinical trials have exposed that 1st Line can help quickly to combat various infections relating to helicobacter, pneumonia, soft tissue infections, upper respiratory tract infections and bronchial infections. Other doctors have reported to us that their patients with various viral infections are asymptomatic, even months later after using a few doses of 1st Line. “...thiocyanate ions are not toxic to human cells... and have little if any effect on probiotic species, making them a near perfect antibiotic system.” Professor Paul Clayton

ACF228™ Dr. Lippman was nominated for the Nobel Prize in Medicine for his work to measure free radical production within the body and as everyone knows free radicals are unstable molecules that cause a lot of damage associated with aging and degeneration. The result of Dr. Lippman’s work is unique to IAS - ACF228 (this stands for ‘antiaging complete formula’ version 228). The capsules are designed to neutralise damaging free radical production and help to reduce other age related damaging effects such as

Adrafinil resensitizes alpha-1 receptors in the brain to be more sensitive to noradrenaline. This heightens awareness and concentration to prevent narcolepsy (sleeping in the daytime). The results can be quite remarkable, leading to heightened states of awareness and attention, whilst at the same time not affecting sleep patterns nor causing ‘highs and lows’ that were associated with the earlier form of stimulants. Adrafinil is not recommended for continuous use past 3-months unless liver enzymes are being monitored.

Aminoguanidine (pimagedine) Aminoguanidine is internationally recognised as the most potent AGE inhibitor currently available. The abbreviation AGE means ‘advanced glycated end products.’ AGEs are cross linked proteins that do not work efficiently/ correctly and are seen in a number of disorders including diabetes, heart enlargement, skin discoloration and hardening (particularly in smokers), cataracts and even arterial stiffness. (If you want to see glycosylation in action, then cut an apple in half and watch it turn yellow and tough). Our aminoguanidine tablets also contain vitamin B6 so there is no need for extra supplementation.

Andro-Pro™ Andro-Pro contains the latest cutting-edge nutritional ingredients to naturally boost free testosterone levels. The most unique ingredient added to Andro-Pro is the recently discovered fructoborate. Fructoborate is a boron derivative that according to Romanian

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studies is helping to alleviate bone loss and arthritis; but perhaps the most interesting clinical study was done on 13 men. They were given the equivalent of one capsule of AndroPro daily for 60-days, at the end of the 2 months, on average these men experienced serum level increases of vitamin D by 19.6%, DHEA-S up 56% and free testosterone rose by 29.5%. In addition, Andro-Pro also contains the supporting agents of zinc, B6, magnesium and high quality tribulus terrestris. All factors in improving free testosterone production. Adding DIM-Pro 2™ to your regime can help to reduce estrogen levels and therefore improve free testosterone levels even further.

ATP Boost™ ATP-Boost provides 20mg of ATP, the body’s ultimate energy molecule in each capsule. In addition, ATP Boost contains a unique combination of the nutrients acetylL-carnitine and R-lipoic acid that increase mitochondria energy production without the increase in damaging oxidation that usually follows. The result: enhanced energy reserves and reduced aging at the cellular level.

BCI program Dr Garry Gordon is a world expert in detox and chelation (the removal of heavy metals). His oral BCI program is a world leader. Made up of 3 products, it not only provides the right natural materials to help lock-up, remove from tissues, transport through the body and excrete toxins, but also a plethora of protective vitamins, minerals and oils that have been designed to make it as easy as possible to have the most comprehensive all-in-one package.

the gut from the body. Simply add a scoop of the powder into your morning cereals or blend it into your power drink.

UPDATE: For those who want to get metals out of their skin, use Beyond Clean® version 2. This powder is simply added to the bath tub and contains both EDTA and zeolite. Here you simply relax your toxins away!

BEC5 Curaderm® BEC5 Curaderm cream was discovered by Dr. Bill Cham on the Oceania island of Vanuatu. Dr. Cham noticed that when the local farmers rubbed the plant called the ‘devil’s apple’ (found in that region and which is related to eggplant) onto the backs on animals that were experiencing skin cancers - that they had considerable success in its removal. It is known that BEC5 Curaderm has now been used by more than 80,000 patients, all with remarkable success. Clinical trials in the UK and Australia have confirmed the ability of BEC5

The eggplant cancer cure by Bill Cham Ph.D. covers all aspects of BEC5 Curaderm treatment.

Curaderm to regress non-melanoma skin cancers within weeks! For example, one open study with 72 patients had 100% healed skin cancer lesions within just 13-weeks of applying BEC5 Curaderm cream twice daily.

Each sachet in the Beyond Chelation Improved® contains 4 vitamin/ mineral capsules, 3 chelation/ detox capsules, 1 omega 3 fish oil capsule, 1 omega 6 & 9 evening primrose capsule and 1 brain capsule containing gingko biloba and phosphatidylserine. This is a superb daily nutritional supplement just by itself, but to avail yourself of the full program you should add two more agents; Bio-En’R-Gy C® a unique high-strength and stabilised vitamin C powder that can be added to water or juice. It also contains ribose for your heart health along with MSM, betaine and bioperine to lower inflammation and problematic lipids. Fundamentally, it is this product that transports the toxins from the tissues sites that Beyond Chelation Improved® has released, ready for them to be excreted. Then it is over to Dr Gordon’s Beyond Fiber®. It contains the best forms of fiber, specifically extracted from brown rice husks and Jerusalem artichoke, in addition with EDTA. This product enables the body to defecate the toxins collected into 24

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“BEC5 Curaderm is a topical preparation which is safe and effective, an ideal therapy for outpatient treatment... It is a cost effective treatment for both primary and secondary skin cancer care.” Dermatologists at the Royal London Hospital Examples on opposite page showing examples of patients before, during and after treatment with BEC5 Curaderm. A typical treatment period from start to finish is 8 weeks. Furthermore, BEC5 Curaderm is known not to harm healthy cells, therefore only destroying cancer cells on and under the skin’s surface.

What’s more evidence is mounting that Can-C is efficacious for all of the following disorders: cataracts, glaucoma, presbyopia, corneal disorders, eye strain, ocular inflammation, blurred vision, dry eye syndrome, vitreous opacities and lesions, diabeteS mellitus complications, contact lens wearers, (regarding the last point in the list above, Can-C inhibits the accumulation of lactic acid which has greatly benefited those who wear contact lenses, because it enables them to be worn for longer without pain).

UPDATE: Can-C is protected by a patent and your assurance of originality is to look for the IVP hologram on each box.

“What’s near perfection? BEC5 Curadermit’s a treatment that works nearly every time. It’s incredibly simple to use, has no adverse side effects and is inexpensive compared with other treatments.” Jonathan Wright, M.D. BEC5 Curaderm is known to be effective for all the following conditions:

• • • • • •

Basal cell carcinomas (BCC) Squamous cell carcinomas (SCC) Keratoses Keratoacanthomas Age spots Sun spots

Left: A woman’s eye shows the cataract before treatment. Right: 5-months later after use of Can-C eye-drops (two drops twice daily), there is no longer a visible cataract and eyesight has improved. Dr. Kyriazis book, ‘the cataract cure’, details the usefulness and evidence of Can-C eye-drops.

UPDATE: To achieve the best possible results in the quickest possible time, use tamanu oil following the BEC5 treatment.

Can-C™ eye-drops Can-C eye-drops are the original formula for use in cataract and contains a purified and racemized form of n-acetylcarnosine, a natural di-peptide with potent antiglycating and anti-oxidant properties that prevent lipid peroxidation.

Now available from IAS as a FREE e-book: http://www.antiaging-systems.com/can-c-ebook “I am so grateful for the development of Can-C eye-drops, not only have they significantly improved my own eyesight, but many of my patients report most favorably about them too. Now we have a real alternative to eye surgery so Can-C can be considered to be a genuine breakthrough.” Richard Lippman, Ph.D.

Can-C Plus™

Patients in trials placed 2-drops of Can-C into their eyes twice daily. After 6-months of use, 88.9% of patients showed improvement in the clarity of their lens and 90% saw an improvement in their visual acuity. There have been numerous reports of cataract shrinkage and even disappearance with documented evidence that Can-C eyedrops remain effective (and safe) more than 24-months later. The most commonly expressed initial reports are that glare is significantly improved, (for example night driving is much safer) and color perception is enhanced.

Can-C Plus tablets are specially designed to be used alongside the Can-C™ eye-drops to aid and even boost their effectiveness. As there are a few supplements that can block the action of Can-C eye-drops, Can-C Plus tablets have been carefully designed to avoid them. Three Can-C Plus tablets a day can be taken with food, with or without Can-C eye-drops, although for maximum benefit it is recommended that they are used together.

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Centrophenoxine (Centro-Pro™) Like all good antiaging supplements, centrophenoxine has many useful features with few side effects. From a memory and cognition viewpoint, centrophenoxine has demonstrated significant improvements, most notably its ability to speed up the process of memory recall. One of centrophenoxine’s most noted benefits is its ability to effectively and quickly remove a cell toxin that accumulates with age (and Alzheimer’s disease) called lipofuscin. Lipofuscin can make up parts of the socalled Alzheimer brain plaques, but it can even be found in the brains of ‘normal’ aging people as well as other organs such as the heart, the lungs and even the skin- where it forms part of the so-called age or liver-spots, the brown flecks found in ‘aged’ person’s skin. Indeed several weeks of centrophenoxine supplementation has seen removal and lightening of such spots. “Centrophenoxine has shown many facets to improve conditions related to my membrane hypothesis of aging, for example its ability to improve brain-performance, survival time in animal experiments, and to remove the cell aging-pigment called lipofuscin. It has been my antiaging supplement for more than 30-years.” Professor Imre Zs.-Nagy

CoQ10 (coenzyme Q10) CoQ10 is a universal energy agent that has significant protective qualities for the heart and the cardiovascular system. An important point- anyone taking a statin drug to lower cholesterol must also be taking CoQ10 since statins lower CoQ10 levels.

UPDATE: Our CoQ10SR™ is a slow release version combined with cyclodextrin, a new technology that enables greater bioavailability by improving the passage through the stomach into the blood. It has been clinically shown that CoQ10SR™ has up to twice the bioavailability of ‘regular’ CoQ10. Thus depending on how you look at it, CoQ10SR is either double the effectiveness of CoQ10’s of the same dose, or half the price of CoQ10’s of twice the dose!

Curcumin™ By harnessing the power of the natural healer, curcumin, (found in turmeric) we have access to a wide-ranging set of positives. From bolstering the immune system, to moderating inflammatory responses, it can also act as an anti-viral and an anti-fungal agent. It’s even been found to have the ability to 26

counter many conditions including a very recent study as an antidepressive.

UPDATE: Our CurcuminSR™ is a unique slow release version that is much more bioavailable than regular versions.

Deprenyl (selegiline) Parkinson’s disease is characterised by the loss of the brain neurotransmitter dopamine. Deprenyl helps to prevent this loss by acting on the specific enzyme MAO-b. Professor Knoll also believes that deprenyl very significantly increases PEA (phenylethylamine) and that this may have an even more significant function than the MAO-b inhibition, (for more details on this please read Professor Knoll’s excellent book on the subject- ‘the brain and its self’). Professor Jozeph Knoll of Debrechen University in Hungary- the inventor of deprenyl

In addition to improving dopamine levels, deprenyl has also been shown to help rebalance serotonin, noradrenaline and acetylcholine levels and whilst the uses remain ‘off-label’ deprenyl has been used for Alzheimer’s and even cancer treatments. Our focus here is upon deprenyl’s enhancement of dopamine, which is a key brain chemical responsible for drive, focus and well being and even libido (especially for men). The experiments of Professor Jozeph Knoll dramatically extended the lifespan of rats who were given deprenyl. Even the first rat to die that was treated with deprenyl died after the last rat not treated with deprenyl died.

This graph highlights the loss of dopamine with age, on average 13% per decade past the age of 40 for the average person, but far greater for those suffering from Parkinson’s disease

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The idea behind the antiaging use of deprenyl is to use very small doses regularly in order to help maintain healthy dopamine levels and thus improve cognitive function and help to maintain function at a better level for much longer.

UPDATE: The Dep-Pro™ liquid can dispense selegiline HCL in small quantities as 1 drop = 1 mg.

Esnatri™ cream (bio-identical estrogens) Esnatri cream is the world’s only bioidentical estrogen cream to replicate the work of Dr. Jonathan Wright. Dr. Wright has highlighted that the ‘average’ woman produces estrogens in the ratios of estriol 90%, estradiol 7% and estrone 3% and these are the exact same ratios found inside Esnatri. Each 1ml of Esnatri cream provides 2mg in total of the triple estrogens and it enables a precise, natural and indeed bioidentical hormone replacement therapy for women concerned about the menopause. IAS provides dose and timing advice from Dr. Wright for both estrogens and progesterone with every purchase. The additional use of bioidentical progesterone should be used along with an estrogen replacement program. For further information on estrogens we recommend one of Dr. Thierry Hertoghe’s Hormone handbooks.

GABOB (Gamibetal®) Technically it is the closest legal molecule to GHB. Its approved use in Europe is to help with epilepsy, but like GHB, GABOB has been shown to improve growth hormone release significantly when taken before bedtime. GABOB does not have the ‘sleep inducing’ effects of GHB, but it can cause some sedation if taken in high doses.

GHRP2 GHRP2 is growth hormone releasing peptide number 2. It is a potent releaser of HGH for fat loss and is particularly synergistic with sermorelin. It is best taken in the morning, by swallowing 4ml of the liquid. Up to 10ml may be used for shorter periods of time.

UPDATE: The work of Dr Richard Walker highlights that GHRP2 is particularly effective/ synergistic when combined with sermorelin.

Glutathione (also see ACF228™ Breathe-Easy)

Glutathione is a potent antioxidant that helps to prevent damage to important cellular components that can be caused by reactive oxygen species such as free radicals and peroxides. Glutathione is principally synthesized inside the body and is relatively poorly obtained via the diet. The Advanced Cellular Glutathione supplement is a spray providing nano sized particles for sub mucosal absorption to create instant bioavailability.

Hair-Pro™ Hair-Pro is the very latest development to help induce hair growth. It contains the absolute latest cutting-edge growth factor technologies. Hair Pro is a unique proprietary topical liquid blend that includes finasteride, (the DHT blocking drug used orally for years as a hair loss treatment). It also contains a plethora of amino acids that act as hair growth factors including bFGF, TRX, VEGF and IGF-1. In addition there is aminosyn to promote protein synthesis (hair strength), hyaluronic acid to aid hair hydration (thickness) and dexpanthenol to cleanse the pores of the blocking fat- sebum which can block nutrition from the hair root. It’s a unique and potent formula to battle alopecia.

UPDATE: Use it in combination with the Scalproller to improve uptake into the scalp.

Hydergine (ergoloid mesylate) Hydergine is an extract of a fungus that grows on rye called ergoloid mesylate. Its approved uses have been to aid persons with memory disturbances, Alzheimer’s disease and even for persons who have suffered from electric shock, drowning or suffocation. This is because hydergine stabilises the levels of oxygen in the brain. It has been shown to improve oxygen levels when they are too low and decreases levels when they are too high. The result of this optimised oxygen availability in the brain is an ability to do more mental work without becoming tired. Accordingly, hydergine can be a good tool to battle through boring paperwork or a long drive home in the dark. A fascinating animal experiment showed a special ability for hydergine to improve mitochondrial condition. The

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mitochondria are vital organelles found in every cell of our body responsible for the generation of ATP, the universal energy molecule. Unfortunately mitochondrial efficiency declines as we age. However, an Italian study highlighted that old animal mitochondria can be improved with hydergine supplementation. The Bertonin-Freddari et al, 1994 study highlights that hydergine can improve the size, volume and number of mitochondria in old animals- towards the youthful example; as is shown here the difference between young, old (without hydergine) and old (with hydergine) is significant. Hydergine also stimulates the growth of dendrite nerve fibers. These connective strands are known to decline in aging. This is another antiaging feature of hydergine. Some have even linked the density and numbers of dendrite fibers to the level of I.Q. In summary, hydergine helps to protect against conditions of hypoxia and peroxidation, important factors to guard against a stroke and generalised brain injuries. Hydergine can extend the boundaries of mental workload and energy, fighting against boredom and may even provide some groundwork for raising the levels of intelligence.

UPDATE: Hydergine was the brand name of Novartis, who after many years have decided to stop manufacture purely on commercial grounds. Therefore, IAS has sourced pharma quality ergoloid mesylates in the same dose of 4.5 mg.

Melatonin (MZS™) Melatonin is one of nature’s remarkable substances. It is made in response to darkness by the pineal gland. Melatonin’s benefits to help overcome jet lag and shift work have become quite well known and indeed it is useful for this purpose since adequate melatonin availability enables our bodies to be correctly in tune with our circadian rhythms. These circadian rhythms dictate our hormonal cyclicity and this cyclicity ultimately determines our aging and our level of immunity. Unfortunately melatonin secretions decline with aging. Professor Pierpaoli has published widely on melatonin, principally through the New York Academy of Science and at the meetings of the Stromboli conferences on aging and cancer- which IAS is delighted to support. What is important to know about melatonin is that Professor Pierpaoli advocates a 3mg dose to (his words) “put the pineal to sleep.” In addition, it is also vital to use a melatonin that produces a night peak of melatonin that is the same as the peak produced by the pineal itself. Thus he has achieved using specific excipients in his own formula ‘MZS™’ (which also contains the additional synergistic ingredients of zinc and selenium). 28

This graph highlights that Professor Pierpaoli’s Melatonin Zn Se formula mimics the night peak of melatonin. Note that sublingual melatonin tested peaks too soon and that time released formulas peak too late. Here are some before and after Fundus photos showing the benefit of Melatonin Zn Se. They highlight dramatic improvements to both wet and dry forms of macular degeneration. In a trial published in the New York Academy of Science, 110 eyes, (100 patients) with both wet and dry forms of ARMD were treated only with 1 tablet of Melatonin Zn Se nightly. After 6-months 90% of the treated patients’ eyes had significant improvements to their condition. This is simply remarkable compared to the current approved therapy for ARMD which involves injecting the eye quarterly, (costs $1000+) with 50% improvement at 24-months! For further detailed information about melatonin and Professor Pierpaoli’s work we recommend his book ‘the key of life,’ it is now available as a FREE e-book from the IAS website.

Minsaw™ MinSaw has been updated numerous times, but now it’s in its best formula ever. MinSaw provides all of these proven hair growth and protectors in its latest formula: • Minoxidil: Perhaps the best known agent to help stimulate hair growth, which it does by increasing nitric oxide promotion in the root of the hair. In doing so it delivers more nutrition for the hair to grow faster. MinSaw has the most potent amount of minoxidil at 8%. • Vitamin C: Helps stimulate hair growth and ‘clean’ the root bulb. MinSaw contains the active form of L-ascorbic acid. • Saw Palmetto: This herb helps to block the damaging effects of DHT, a known hair growth restrictor. • Resveratrol: The remarkable protective agent found in red grape skins has recently been noted to help induce hair thickness. • Melatonin: This has been documented and patented to help prevent hair loss. • Retinolic acid (also known as tretinoin). This super high strength vitamin A improves skin condition by enhancing blood flow to the skin. In the same way, this ingredient

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improves the blood supply around the hair root, helping it to be stronger and healthier. Just apply a small amount of MinSaw daily to the scalp and see the results for yourself in a few weeks time. Use it in combination with the Scalproller to improve uptake into the scalp.

MSH2-Pro™ MSH2 is the abbreviation for melanocyte stimulating hormone (type II). This hormone has a direct effect on tanning the skin and if used regularly will darken skin- even without exposure to the sun. In addition, MSH has been noted to enhance libido and suppress the desire to eat. NOTE: MSH use should not exceed 2-sprays per day and must not be used by persons with hypertension, (high blood pressure).

Naltrexone The results of low dose naltrexone, (widely known as LDN) therapy have been remarkable. Originally, the use of naltrexone was in the management of dependence on opioid and alcohol. But it was Dr. Bernard Bihari in the 1980’s who first used low dose naltrexone for the treatment of HIV and then for a number of other autoimmune diseases such as multiple sclerosis, Crohn’s disease and many immunological related diseases. Many MS patients have reported an improved quality of life. A leading study has established that by maintaining regular nightly LDN, less than 1% of the MS sufferers experience fresh MS attacks. IAS supplies the LDN dose of 4.5 mg.

could be efficacious in the treatment of autism and even schizophrenias. But it is perhaps its ability to enhance bonding between partners that is likely to attract most attention. Oxytocin increases ejaculate in the male and has significant libido enhancement effects in females, including the inducement of multiple orgasms. We have worked alongside Dr. Hertoghe to create a practical and efficacious sublingual trouche (a gel like tablet). Typical doses are 5 to 20 IU. (The square troches can be cut in half from corner to corner easily).

UPDATE: Oxy-Pro™ is a new nasal spray version of oxytocin (delivering 10 IU per spray) in addition to our 20 IU sublingual trouches (Oxy-Sub™).

Peptide Bioregulators These are the very latest technology from Professor Khavinson in Russia. They utilise highly specific peptides extracted from Danish bovine sources. These peptides have been shown to be a short-cut to protein synthesis by activating directly with their receptive genes. Therefore their action is to ‘reinvigorate’ their respective gland/ organ, to induce their biological reserve and essentially rejuvenate their processes. 1.Bobothyrk® is the peptide for the parathyroid. 2.Bonomarlot® is the peptide for the bone marrow. 3.Cerluten® is the peptide for the central nervous system (brain). 4.Chelohart® is the peptide for the heart. 5.Chitomur® is the peptide for the bladder. 6.Endoluten® is the peptide for the pineal. 7.Glandokort® is the peptide for the adrenal glands. 8.Gotratix® is the peptide for the muscles. 9.Libidon® is the peptide for the prostate gland. 10.Pielotax® is the peptide for the kidneys. 11.Sigumir® is the peptide for the cartilage. 12.Stamakort® is the peptide for the stomach. 13.Suprefort® is the peptide for the pancreas. 14.Svetinorm® is the peptide for the liver. 15.Taxorest® is the peptide for the lungs.

Oxytocin (Oxy-Pro™)

16.Testoluten® is the peptide for the testes. 17.Thyreogen® is the peptide for the thyroid. 18.Ventfort® is the peptide for the blood vessels.

Oxytocin is a hormone produced in the hypothalamus and secreted into the blood by the pituitary gland.

19.Visoluten® is the peptide for the eye retina. 20.Vladonix® is the peptide for the thymus. 21.Zhenoluten® is the peptide for the ovaries.

Oxytocin has been described in detail in Dr. Thierry Hertoghe’s latest book- Passion, Sex and Adventure, the oxytocin story.

Oxytocin has pain curbing abilities and could be efficacious in fibromyalgia. Other studies are highlighting that oxytocin

UPDATE: The recommended course is to start at 2 capsules a day for 30-days (total 60 capsules). Afterward the course can be repeated at 2 capsules a day for 10-days (total 20 capsules) each quarter. Thus, after the initial intensive course all that is required are 4 boxes a year.

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Piracetam (Nootropil®; also see Anacervix®) Piracetam was the very first nootropic, (commonly called smart drugs) to be developed. Despite being one of the very first products that IAS offered when we went online in 1991, it remains one of our best selling products today! Why? Because it is a very beneficial memory agent that has a great safety record, with very few side effects. Plus, it is cost effective. Piracetam has been shown to be safer than salt. This may be because it has a very small impact upon brain chemical levels and helps to improve electrical communication across the brain’s corpus callosum. The corpus callosum is the bundle of nerves that separates the two hemispheres of the brain. In medical terms piracetam is used to improve short term memory and to treat a wide variety of senile dementias as well as autism and Down’s syndrome and can also assist with travel and altitude sickness. Note: IAS offers the original UCB brand called Nootropil which is available in tablet and liquid form. The liquid form was specifically designed for children (it is sweetened with saccharin), but its advantages include being able to titrate low doses (if required) and also aid any person who has difficulty swallowing tablets.

NEW: A great value generic piracetam is now available under the name of Pira-Pro™.

PQQ (pyroloquinoline quinone) PQQ is the most newly discovered vitamin. In more than 200 studies it has been shown to improve overall energy levels, cognitive function and memory, reduce mitochondrial degradation and increase skin elasticity. Furthermore, it acts as a neuro and cardio protectant and helps to enhance nerve growth.

Progesterone Progesterone is often the ‘missing’ hormone in the treatment of female menopause. What we mean by this is that whilst estrogen treatments, (see Esnatri™ for details) are often considered as a primary replacement hormone for women, progesterone is often forgotten about. The best known action of progesterone is its ability to help build bone mass. Progesterone levels fall rapidly in menopause and contribute to osteoporosis. Progesterone is strongly advocated to be taken in combination with any estrogen replacement program. 30

UPDATE: Our progesterone strength is Pharma grade. At 5% it is twice the dose that is found in US health food stores. Progesterone levels decline in women with age; in some cases progesterone levels are undetectable! We recommend one of Dr. Hertoghe’s hormone handbooks for further information about progesterone.

Releasing-Pro® Releasing-Pro is a unique nasal spray that is designed to carry GHRP-6 into the bloodstream. GHRP-6 is an analogue of Ghrelin that has been shown to have significant enhancement effects on IGF-1 levels.

Retin-A®

(Retirides®)

Retin-A contains retinolic acid, a pure form of vitamin A that enhances blood supply to the skin’s surface and transforms the thicker, tougher skin into more youthful looking, elastic and fresher skin. Retin-A is the cream of choice for cosmetic surgeons to speed up the wound healing of cosmetic surgery and scarring etc.

UPDATE: We now also supply the new Retin-A® micro-gel which is designed to sit on the skin surface and release slowly.

Sermorelin

(Serm-Pro™)

Sermorelin is a breakthrough development in the field of growth hormone (GH) replacement. Sermorelin is the bioidentical molecule used by the pituitary gland to stimulate the production and release of GH into the bloodstream. Sermorelin is not GH; GH is a complicated molecule consisting of 191 amino acids. Sermorelin is a chain of 29 amino acids. Importantly it is the first 29 amino acids of GH, the part responsible for activation. This is what makes sermorelin stand head and shoulders over all previous agonists of GH. Sermorelin is GH site-specific and therefore very effective. What is more, sermorelin has a negative feedback loop (unlike GH itself), so the issues of overdosing and safety associated with injections of GH are minimized/ completely avoided. Sermorelin is stable at room temperature and efficacious when used sublingually. These are additional factors that favor sermorelin as the next generation of GH activators. We are excited to introduce this sublingual liquid version of sermorelin which has been created

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with the close cooperation of Dr. Richard Walker of SARA (Scientific Applied Research into Aging), a world renowned antiaging expert.

UPDATE: Sermorelin is synergistic with GHRP2 or GHRP6.

TA65® TA65 contains a highly purified specialized extract of the Chinese herb astragalus. What makes this supplement totally unique is that it is the first natural substance that has been proven to act as a telomerase activator and to extend telomeres in humans (in-vivo). Telomeres are the strands on the ends of chromosomes that shorten each time the cell divides. This is a significant part of the destructive process of aging. Animals with longer telomeres enjoy a more productive and healthier older age and appear to live longer. TA65 production is carefully controlled by TA Sciences, who purchased the technology from the Geron Corporation. Whilst other substances have claimed to delay the shortening of telomeres, only TA65 has been clinically proven (and published) to actually lengthen short telomeres in humans. If you want the cutting-edge of antiaging supplementation and the best possible chances for longer telomeres, then TA65 is currently your best (and indeed only) clinically proven choice.

Thyroid (Armour®; Synthroid®) A decline in the secretion of hormones from the thyroid gland (hypothyroidism) can result in poor concentration, confusion, memory problems, cold hands and feet, weight gain, menstrual problems, sleep disorders, dry skin, thinning hair and low energy levels. An underactive thyroid is also a major cause of a common painful musculoskeletal condition known as fibromyalgia. Aging often leads to hypothyroidism. One of the most famous thyroid experts, Dr. Broda Barnes, stated that as many as 40% of the adult population could be hypothyroid. Thyroid supplements come in two forms; natural supplements and synthetic supplements. It is almost always better to use a whole-natural thyroid extract because the synthetic versions usually only comprise one of the thyroid hormones, (such as, T3 or T4), whereas, wholenatural thyroids cover a fuller spectrum of thyroid hormones (including T1, T2, T3 and T4). For further details about thyroid we recommended one of Dr. Hertoghe’s hormone handbooks.

TRH (Abaris™) TRH is a hypothalamic hormone (technically a tri-peptide) whose real uses and benefits are just coming to the fore, primarily after research conducted by Dr. Walter Pierpaoli, the physician and scientist who exposed the benefits of melatonin to the world. Dr. Pierpaoli’s research suggests that TRH is a ‘master’ hormone responsible not just for helping to adjust thyroid hormones (its principle recognised role), but in helping to recorrect many imbalances throughout the body. For example in his animal experiments TRH supplements have encouraged old animals to: •

Re-establish spermogenesis, (reversing the age-related dysfunction of their testes).

•

Correct kidney dysfunction, (a significant finding for renal issues).

•

Correct pancreatic dysfunction, (a significant finding for diabetic issues).

•

Improves many lipid profiles and aids weight loss when used over a few months.

IAS is delighted to be the first organisation in the world to offer a sublingual TRH tablet.

Vasopressin Vasopressin is a porcine extracted source for this pituitary hormone which has a number of interesting roles. Its approved medical use is to prevent frequent urination in conditions such as diabetes insipidus. For example, men with prostate conditions can benefit by less trips in the night to urinate. But vasopressin is also responsible for the laying down of memories in the hippocampus and it has been used to treat amnesia. In particular, it is cited by many for memory imprinting, this is the learning of new material before it is experienced. Therefore taking 1 or 2 sprays into each nostril 15-minutes before an exam, meeting or lecture etc., can induce a better detailed recall of events later.

ZeoGold Enhanced® ZeoGold Enhanced is the latest zeolite formula from world chelation and detox expert, Dr. Garry Gordon. In this new ‘enhanced’ formula Dr. Gordon has included the highest grade of zeolite for detox purposes along with the methylation agents and now added hydrogen for enhancement of energy.

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Product A-Z listing Here is an alphabetical listing of IAS stocked products. See our cross-reference list of disorders that relate to these individual products. Much more information is available from our website including full ingredient/ excipient listings, doses and side effects etc. If you need any further information or can’t find what you require, please don’t hesitate to contact us. The inside back cover has all our details.

Testimonials “IAS has shown great vision and leadership, as an organisation focused mainly on the provision of contemporary medical interventions against aging, and in also supporting the SENS Foundation’s efforts to hasten the development of much more powerful future interventions.” Dr. Aubrey De Grey “IAS is an outstanding resource for the finest, most up-to-date news and information on healthy aging. They also offer products of the highest integrity and efficacy. In fact, IAS is the world’s greatest source (often the only source) for the most cutting edge and advanced nutrients to ensure optimum health span and maximum life span.” Nicholas Perricone, M.D.

The following index underneath certain products means that known restrictions apply. For example: Not shipped to UK Not shipped to EU Not shipped to Japan Not shipped to Australia (or New Zealand) Not shipped to Canada Note: For use strictly by IAS private club members - IAS terms and conditions apply. All information is educational and does not replace the advice of your physician. Prescriptions are necessary where required by law; other restrictions may apply in some countries.

“IAS has a history of making throughout the world crucial, but difficultly accessible medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has helped this new medical specialty move forward.” Thierry Hertoghe, M.D. “I am a 77 year old Physician who has practiced medicine for nearly half a century. My antiaging research has permitted me to overcome serious health problems. Everyone can do this, but it requires specialized knowledge and the highest quality products. IAS is a vital link in my antiaging program because they continually provide both accurate information AND the high quality products we all require, if we are to achieve our maximum intended useful lifespan.” Garry Gordon, MD, DO, MD (H) “Every adult has the right to take care of his or her own personal health as he or she chooses. In the 20th and 21st centuries, this universal human right has been nearly obliterated by an ocean of nanny-state regulation and deliberate suppression of information by bureaucracies, with hidden and not-so-hidden agendas. International Antiaging Systems is a beacon of useful health care information and a literal island of freedom of health care product choice in our otherwise un-free health care world.” Jonathan Wright, M.D. See all professional and public testimonials at: www.antiaging-systems.com/content/11-testimonials

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1st Line™ (OSCN, thiocyanate)

Anacervix®

5HTP (5-hydroxy-tryptophan)

Anastrozole (Arimidex®)

1 complete kit retail $90 IAS price $79.99 Item Code: 675

5HTP-Pro™ 60x 50mg capsules retail $20 IAS price $17.49 - Item Code: 327

Acarbose

Glucobay® 30x 100mg tablets retail $30 IAS price $27.49 - Item Code: 373

Acetyl-L-Carnitine (see ATP-Boost™)

ACF228™

ACF228™ 45 capsules retail $60 IAS price $49.99 - Item Code: 621

NEW: ACF228™ Breathe-Easy 1 inhaler retail $150 IAS price $139.99 - Item Code: 810 Adenosine Triphosphate (see ATP)

Adrafinil

Anacervix® 30x 420mg capsules retail $29 IAS price $24.99 - Item Code: 163

Anastrozole 28x 1mg tablets retail $149 IAS price $139.99 - Item Code: 849 Anastro-Pro™ 28x 100mcg capsules retail $39.99 IAS price $34.99 - Item Code: 779

Andro-Pro™

Andro-Pro™ 60 capsules retail $55 IAS price $49.99 - Item Code: 758

Aniracetam

Ani-Pro™ 20x 750mg capsules retail $35 IAS price $29.99 - Item Code: 777

Arginine (see Beyond GHS®; Nitric-Pro™), Argireline (see Crème-Pro™ Smoother), Arterial wave velocity (see Bio-Clip & Bio-Cuff)

Adra-Pro™ 40x 300mg capsules retail $60 IAS price $49.99 - Item Code: 775

Ascorbyl palmitate (see Crème-Pro™ Protector, Crème-Pro™ Smoother), Astaxanthin (see CrèmePro™ Protector), Astragalus extract (see TA65®)

Agomelatine (see Valdoxan)

ATP (Adenosine Triphosphate)

ATP-Boost™ 60x 20mg capsules retail $35 IAS price $29.99 - Item Code: 821

Aldosterone

NEW: AldoSpray 10mg/5ml Ear Spray retail $160 IAS price $149.99 - Item Code: 982

ATP-Boost™ (see ATP), Azilect® (see rasagiline)

Alfalfa (see Dr Gordon’s Organic Greens®), Allicin (see garlic), Alpha lipoic acid (see lipoic acid)

B12 (vitamin B12)

Aminoguanidine (pimagedine) Amino-Pro 90 x 75mg tablets retail $29 IAS price $24.99 - Item Code: 977

Aminohydroxybutyric acid (see GABOB), Aminophylline (see Crème-Pro™ Cellulite), Aminosyn (see Hair-Pro™), Amphoteric surfactants (see Nanogen® shampoo, Nanogen® conditioner)

Beyond B12® 40x 2mg sublingual tablets retail $30 IAS price $29.99 - Item Code: 477 NEW: Cromatonbic® 8x1mg i.m.ampoules retail price $20 IAS price $17.49 - Item Code: 951 Barley grass (see Dr Gordon’s Organic Greens®), BCI (see Beyond Chelation Improved®)

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B-Cure® laser 1 Unit

Bio-CUFF™

BEC5 Curaderm®

Bio-En’R-Gy C®

B-Cure® laser 1 Unit retail $795 IAS price $749.99 - Item Code: 850

BEC5 Curaderm® 20ml tube cream retail $156 IAS price $144.99 - Item Code: 403 FREE Hemagel worth $17.99

Beetroot (see Neo40®)

Benfotiamine

Milgamma Mono® 30x 50mg tablets retail $25 IAS price $22.49 - Item Code: 273

Bio En’R-Gy C® 200 grams powder retail $60 IAS price $59.99 - Item Code: 591

Bioflavonoids (see Wobenzym®), Biological age measurement (see Bio-CLIP™, PulmoLife®), Bioperine (see Bio-En’R-Gy®), Biotin (see Beyond B12®; Beyond Chelation Improved®, HRT Plus®; BCI; Nitric-Pro™), Blood oxygenation measurement (see Bio-CLIP™), Blood pressure measurement (see Bio-CUFF™), Blueberry extracts (see Andro-Pro™)

Benzoic acid (see Gerovital®), Beta alistine (see L-carnosine), Beta glucan (see Beyond Chelation Improved®, Nanogen® serum), Betaine (see TMG), Beta sitosterol (see Beyond Chelation Improved®), Beyond Any Multiple® (see Beyond Chelation Improved®)

Boluoke® (Lumbrokinase)

Beyond Chelation Improved® (BCI)

NEW: Bone-Pro2™ 60 capsules retail $39 IAS price $32.99 - Item Code: 870

Beyond Chelation Improved® 30 sachets retail $80 IAS price $79.99 - Item Code: 351 Note: Also called Beating Cellular Impurities by Dr Garry Gordon

Beyond Clean® v2 (Calcium

NEW: Boluoke® 60 capsules retail price $108 IAS price $94.99 - Item Code: 839

Bone-Pro2™

Borate (see Andro-Pro™, Can-C™), Boron (see Andro-Pro™, Beyond Chelation Improved®, BCI)

Bromocriptine

Parlodel® 30x 2.5mg tablets retail $29 IAS price $24.99 - Item Code: 58

EDTA & Zeolite)

Bromelain (see Digestif®, Wobenzym®), Buxamin (see GABOB)

NEW: Beyond Clean® v2 32 oz. bath salts retail $70 IAS price $69.99 - Item Code: 881

Cabergoline (Dostinex®)

Beyond Fiber®

Beyond Fiber® 504 grams powder retail $50 IAS price $49.99 - Item Code: 436

bFGF (see Hair-Pro™), BHT (butylhydroxytoluene, see ACF228™)

Bio-CLIP™

complete kit retail $1300 IAS price $1299.99 - Item Code: 653

Bio-CUFF® one complete kit retail $160 IAS price $149.99 - Item Code: 715

Dostinex® 8x 0.5mg tablets retail $80 IAS price $74.99 - Item Code: 612

Caffeine (see Crème-Pro™ Cellulite), Calcium (see Bone-Pro™, Beyond Chelation Improved®, Nitric-Pro™)

Can-C™ eye-drops

Can-C™ 2x 5ml vials retail $45 IAS price $39.99 - Item Code: 456

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Can-C™ Plus

Can-C Plus™ 90 tablets retail $40 IAS price $34.99 - Item Code: 629

CoQ10SRTM (Coenzyme Q10, ubiquinol, biquinone)

NEW: CoQ10SRTM 30 x 100mg slow release capsules retail $30 IAS price $25.99 - Item Code: 824

Carboxymethylcellulose (see Can-C™) , Carbidopa (see Sinemet®), Carnosine (L-carnosine, see ACF228™, Can-C™, Can-C Plus™, L-carnosine), Catalase (see ACF228™)

Copper (see Beyond Chelation Improved®), Cortisol (cortisone, see Fludrocortisone, hydrocortisone), Cranberry extracts (see Andro-Pro™)

Centrophenoxine (meclofenoxane)

Crème-Pro™ Cellulite

Cerebrolysin®

Crème-Pro™ Moisturizer

Chlorella (see Dr Gordon’s Organic Greens®), Choline (see Beyond Chelation Improved®, centrophenoxine, krill), Chromium (see Beyond Chelation Improved®), Chromium polynicotinate (see ACF228™)

Crème-Pro™ Protector

Cialis® (tadalafil)

Crème-Pro™ Smoother

Cialis® 4x 20mg tablets retail $85 IAS price $79.99 - Item Code: 296

Crème-Pro™ Smoother 30ml pump cream retail $69 IAS price $59.99 - Item Code: 831

Ciproxin® (ciprofloxacin)

Cresote bush (see ACF228®, Digestif®)

Centro-Pro™ 60x 250mg tablets retail $30.00 IAS price $24.99 - Item Code: 243

Cerebrolysin® 5x 5ml i.m. ampoules retail $95 IAS price $84.99 - Item Code: 595

Ciproxin® 14x 500mg tablets retail $35 IAS price $32.49 - Item Code: 948

Citrus bioflavonoids (see Beyond Chelation Improved®), Cocos nucifera oil (see Nanogen® conditioner)

Crème-Pro™ Cellulite 30ml pump cream retail $34 IAS price $24.99 - Item Code: 828

Crème-Pro™ Moisturizer 30ml pump cream retail $44 IAS price $39.99 - Item Code: 829

Crème-Pro™ Protector 30ml pump cream retail $59 IAS price $49.99 - Item Code: 830

CurcuminSR™ (turmeric extract)

NEW: CurcuminSR™ (slow release) 30x 125mg capsules retail $25 IAS price $21.49 - Item Code: 841

Cycloastragenol (see TA65®), Cyclodextrin (see CoQ10SR™), Cyprenil® (see deprenyl)

Cobalt chloride

Cobalt 100x 200mcg tablets retail $55 IAS price $49.99 - Item Code: 646

D3 (vitamin D)

Coenzyme Q10 (see CoQ10)

D3-5000™ 100x 5000 IU capsules retail $20 IAS price $14.99 - Item Code: 843

Colchicine (Colcrys®)

NEW: D3-Pro2™ 12x 50,000 IU capsules retail $30 IAS price $24.99 - Item Code: 842

NEW: Colchicine 40x 1mg tablets retail $19 IAS price $17.49 - Item Code: 835

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Deprenyl (selegiline)

Dr. Gordon’s Organic Greens

Dep-Pro™ 20ml/ 300mg liquid (HCL) bottle retail $90 IAS price $84.99 - Item Code: 746 Jumex® 50x 5mg tablets retail $65 IAS price $54.99 - Item Code: 35

Dutasteride

Dercos® (aminexil)

Avodart® 30x 0.5mg tablets retail $89 IAS price $79.99 - Item Code: 276

Organic best of greens® 10 oz. bottle powder retail $35 IAS price $34.99 - Item Code: 688

Dercos® 200ml bottle shampoo retail $25 IAS price $22.49 - Item Code: 17

Desmopressin (also see

vasopressin)

Minurin® 2.5ml nasal spray retail $39 IAS price $34.99 - Item Code: 229

DHA (docosahexaenoic acid, see krill), Diapid® (see vasopressin)

Digestif™

Digestif® 60 capsules retail $19 IAS price $14.99 - Item Code: 626

Di-IndolylMethane (DIM, see ACF228™, DIM-Pro™), DIM (see ACF228™, DIM-Pro™), Dimethicone (see Nanogen®)

DIM-Pro2™

NEW: DIM-Pro2 ™ 100 capsules retail $50 IAS price $44.99 - Item Code: 844

DMAE (dimethylaminoethanol, see centrophenoxine, Crème-Pro™ Smoother), DMSA (dimercaptosuccinic acid, see ACF228™), DMSO (Dimethyl sulfoxide, see laetrile), Docosahexaenoic acid (see DHA), Dostinex® (see cabergoline)

Doxycycline

Doxycycline 8x 100mg capsules retail $29 IAS price $24.99 - Item Code: 164

D-pantethine (see Can-C Plus™), D-panthenol (see Nanogen® conditioner)

Ebixa (see Memantine) EDTA (ethylene diamine tetraacetic acid, see Beyond Chelation Improved®, Beyond Clean®, Beyond Fiber®), Eldepryl® (see deprenyl), EPA (eicosapentaenoic acid, see krill), Ergoloid mesylate (see hydergine, nicergoline)

Esnatri™ cream (bio-identical triple estrogen cream)

Esnatri™ 50ml 100mg cream retail $55 IAS price $49.99 - Item Code: 25 Essential Daily Defence® (see Beyond Chelation Improved®), Estradiol (see Esnatri™), Estriol (see Esnatri™), Estrone (see Esnatri™)

Finesteride (also see Hair-Pro™) Finesteride generic 28x 5mg tablets retail $40 IAS price $37.49 - Item Code: 749 Proscar® 15x 5mg tablets retail $45 IAS price $39.99 - Item Code: 67 Florinef® (see Fludrocortisone)

Fluconazole (Diflucan)

Loitin® 7x 50mg capsules retail $39 IAS price $34.99 - Item Code: 307

Folic acid (folate, see ACF228™, Beyond Chelation Improved®, Beyond B12®; Dim-Pro2™, HRT Plus®, Lithium-Pro™, Nitric-Pro™), Forced Expiry Volume- Lungs (see PulmoLife®)

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Fludrocortisone

Fludro-Pro™ 100x 20mcg tablets retail $24 IAS price $19.99 - Item Code: 759

Fructoborate (see Andro-Pro™), GABA (gamma-aminohydroxybutyric acid, see Gamalate B6®, picamilone)

Gabapentin

NEW: Neurontin® 100x 300mg capsules retail $49 IAS price $44.99 - Item Code: 875

GABOB (also see Gamalate®)

Gamibetal® 20x 500mg tablets retail $39 IAS price $34.99 - Item Code: 402

Galantamine (Reminyl®)

Galantamine Pro 30x 8mg tablets retail $79 IAS price $69.99 - Item Code: 825

Gamalate®

Gamalate B6® 60x 250mg tablets retail $24 IAS price $19.99 - Item Code: 27

Garlic (see see Beyond Chelation Improved®), Genotropin® (see HGH)

Gerovital-H3®

Gerovital-H3® 5x 5ml ampoules retail $59 IAS price $49.99 - Item Code: 258

Gerovital-H3® 25x 100mg tablets retail $35 IAS price $29.99 - Item Code: 29

Glutathione (also see ACF228™

Breathe Easy)

Advanced Cellular Glutathione® 2 oz. spray retail $45 IAS price $44.99 - Item Code: 832 Glycerine (glycerin, see Can-C™), Glycosides (see BEC5 Curaderm®), Grape seed extracts (see Beyond Chelation Improved®, Resveratrol-Pro™), Green tea extracts (see Resveratrol-Pro™), Growth hormone (see HGH)

Hair-Pro™

NEW: Hair-Pro™ 2 oz. spray bottle retail $180 IAS price $169.99 - Item Code: 765

Hawthorne Berry (crataegus, see Beyond Chelation Improved®, Neo40®), Heart rate measurement (see Bio-CLIP™, Bio-CUFF™), HGH (human growth hormone, somatropin, see IGF-1, Sermorelin, Beyond GHS®, GABOB, GHRP2, GHRP6), Humatrope® (see HGH)

HRT Plus®(pueraria mirifica) HRT Plus® 60 tablets retail $50 IAS price $49.99 - Item Code: 496

Hyaluronic acid (see Hyaluronan, Crème-Pro™ Protector, Hair-Pro™, Novisyn®)

Hydergine (ergoloid mesylate) Hy-Pro™ 30x 4.5mg capsules retail $49 IAS price $39.99 - Item Code: 949

Hydrocortisone

GH3-Pro™ 60x 100mg tablets retail $19 IAS price $14.99 - Item Code: 360

Hydrocort Pro 100x 5mg capsules retail $35 IAS price $29.99 - Item Code: 760

GH (growth hormone, see HGH)

Hydrogen (see Zeogold Enhanced®)

Idebenone (also see Crème-Pro™

GHRP2

NEW: GHRP2-Pro™ 120ml 120mg liquid bottle retail $175 IAS price $159.99 - Item Code: 872

Protector)

NEW: Ideb-Pro™ 60x 30mg tablets retail $29 IAS price $24.99 - Item Code: 492

GHRP6 (see Releasing-Pro™), Ginkgo biloba (see Beyond Chelation Improved®), Glucophage (see metformin)

www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

IGF-1 (insulin like growth factor, see Hair-Pro™ also see Releasing-Pro™), Indol-3-Carbinol (I3C, see DIM)

Injection packs

L-Tryp-Pro™ 50x 500mg capsules retail $20 IAS price $17.49 - Item Code: 666

Intramuscular kit 30x pack retail $30 IAS price $27.49 - Item Code: 439

Lysine (see Nitric-Pro™)

Subcutaneous kit 30x pack retail $30 IAS price $27.49 - Item Code: 438

Maca (lepidium meyenii walp)

Inosine (see Beyond GHS®), Inositol (see Beyond Chelation Improved®), Iodide (see ACF228™), Iodine (see ACF228™, Beyond Chelation Improved®), Isoflavonoids (see HRT Plus®), Ixel® (see milnacipran), Jerusalem artichoke (see Beyond Fiber®), Joint-Pro™ (see Hyaluronan), Jumex® (see deprenyl), Ketoconazole (see Nizoral®)

Laetrile (amygdalin; VitaB17®) Vita-B17 cream 50ml 1% retail $99 IAS price $89.99 - Item Code: 763

L-arginine (see arginine), Lasers (see B-Cure®, Vie-Light®)

Longevity Maca 175 grams powder retail $40 IAS price $37.49 - Item Code: 851 Magnesium (see Andro-Pro™, Beyond Chelation Improved®, Bone-Pro2™, Digestif®, Gamalate B6®, Nitric-Pro™), Malic acid (see Beyond Chelation Improved®), Manganese (see Beyond Chelation Improved®), Mastic (see Digestif®), Meclofenoxane (see centrophenoxine)

Melatonin (Melatonin Zn Se®) MZS™ 60x 3mg tablets retail $30 IAS price $19.99 - Item Code: 701

L-carnosine (also see ACF228™;

Note: The UK can order in Pounds Sterling at: www.melatoninznse.com

Carnosine 60x 250mg capsules retail $25 IAS price $22.49 - Item Code: 784

Memantine (Namenda®; Ebixa®)

Can-C™; Can-C Plus™)

L-citrulline (see Neo40®), L-cysteine (see Nanogen® conditioner), L-dopa (see Sinemet®), Lecithin (see Crème-Pro™ Cellulite), Levodopa (see Sinemet™), L-histidine (see Can-C Plus™), Lemon grass (see Dr Gordon’s Organic Greens®), Licorice (see Beyond GHS®, Digestif®), Lipoic acid (alpha version see Beyond Chelation Improved®; R-version see ATP-Boost™)

Lithium (orotate)

NEW: Lith-Pro™ 100x5mg capsules retail $30 IAS price $24.99 - Item Code: 906

L-methione (see ACF228™; Can-C Plus™), L-proline (see Nitric-Pro™), Lucidril® (see centrophenoxine), Lumbrokinase (see Boluoke®), Lupine extract (see Nanogen® serum)

L-tryptophan

Memantine-Pro™ 42x 10mg capsules retail $105 IAS price $89.99 - Item Code: 826

Melanocyte stimulating hormone (see MSH)

Metformin (Glucophage®) Metforal® 50x 500mg tablets retail $25 IAS price $22.99 - Item Code: 42 NEW: Metformin SR® 56x 500mg tablets retail $30 IAS price $27.99 - Item Code: 874 Methione (see Beyond Chelation Improved®), Milk Protein (see Bone-Pro2™)

Milnacipran (Savella®)

Ixel® 56x 50mg tablets retail $65 IAS price $59.99 - Item Code: 400

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Minerals (ionic)

NEW: Electrolytes (Volt-Pro™) 8 oz. liquid bottle retail $22 IAS price $19.99 - Item Code: 998 NEW: Iodine-Pro™ 2 oz. 225mcg liquid bottle retail $16 IAS price $14.99 - Item Code: 992 NEW: Magnesium-Pro™ 2 oz. 400mg liquid bottle retail $13 IAS price $11.99 - Item Code: 993 NEW: Mineral mouthwash 16 oz. liquid bottle retail $16 IAS price $14.99 - Item Code: 994 NEW: Potassium-Pro™ 2 oz. 99mg liquid bottle retail $14 IAS price $12.99 - Item Code: 996 NEW: Selenium-Pro™ 2 oz. 300mcg liquid bottle retail $17 IAS price $15.49 - Item Code: 997 NEW: Zinc-Pro™ 2 oz. 50mg liquid bottle retail $13 IAS price $11.99 - Item Code: 999

Nanogen® 30ml serum dropper MEN retail $55 IAS price $54.99 - Item Code: 890 Nanogen® 30ml serum dropper WOMEN retail $55 IAS price $54.99 - Item Code: 891

Nanogen® shampoo

Nanogen® 240ml tube shampoo MEN retail $18 IAS price $17.99 - Item Code: 888 Nanogen® 240ml tube shampoo WOMEN retail $18 IAS price $17.99 - Item Code: 889

Needles (see injection packs), Neurontin® (see Gabapentin)

Neo40®

Neo40 Daily® 30x lozenges retail $60 IAS price $59.99 - Item Code: 790

Minoxidil (see MinSaw™)

MinSaw™

MinSaw™ 30ml bottle topical liquid retail $45 IAS price $39.99 - Item Code: 728

Miroestrol (see HRT Plus®), Mito-Pro™ (see ATP-Boost™)

Moclobemide (Manerix®) Moclamine® 30x 150mg tablets retail $29 IAS price $24.99 - Item Code: 39 Molybdenum (see Beyond Chelation Improved®), MSM (methylsulfonomethane, see Beyond Chelation Improved®, Bio-En’R-Gy®, Nitric-Pro™)

MSH (melanocyte stimulating hormone) NEW: MSH2-Pro™ 5ml 500IU nasal spray retail $79 IAS price $69.99 - Item Code: 905

N-acetylcysteine (see ACF228™, Can-C™ Plus), NADH (Nicotinamide adenine dinucleotide, see Crème-Pro™ Moisturizer, PQQ)

Naltrexone (Navcol®)

Naltrex-Pro™ 30x 4.5mg capsules retail $70 IAS price $59.99 - Item Code: 637

Namenda® (see Memantine)

Nanogen® conditioner

Nanogen® serum

Nanogen® 240ml tube conditioner MEN retail $20 IAS price $19.99 - Item Code: 886 Nanogen® 240ml tube conditioner WOMEN retail $20 IAS price $19.99 - Item Code: 887

Nettle root extract (see Prostate-Pro™)

Neydent toothpaste

Neydent toothpaste 50ml tube retail $18 IAS price $15.99 - Item Code: 118

Niacin (nicotinate, niacinamide, see vitamin B3)

Nicergoline

Sermion® 50x 10mg tablets retail $50 IAS price $47.49 - Item Code: 489

Nitric Oxide Saliva Test Strips Neo40® 10 saliva strips $25 IAS price $24.99 Item Code: 866

Nitric-Pro™

Nitric-Pro™ 225 grams powder retail $45 IAS price $39.49 - Item Code: 792

Nizoral® shampoo (2% ketoconazole) Nizoral® 60ml bottle shampoo retail $19 IAS price $14.99 - Item Code: 437

Novisyn® Hyaluronic Acid Novisyn® Hyaluronic Acid 30 x 5ml liquid sachets retail $30 IAS price $29.49 - Item Code: 900

www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

Nordihydroguaiaretic acid (NDGA, see ACF228™, Digestif®), Norditropin® (see HGH), Oat grass (see Dr Gordon’s Organic Greens®), Omega 3 (see Beyond Chelation Improved®, PEO), Omega 6 (linoleic acid, GLA, see Beyond Chelation Improved®, PEO), Omega 9 (oleic acid, see Beyond Chelation Improved®), Oxythiocynate (OCSN, thiocynates, see 1st Line™)

Oxytocin

Oxy-Pro® 5ml 500 IU nasal spray retail $65 IAS price $59.99 - Item Code: 823

Oxy-Sub™ 24x 20 IU sublingual troches retail $85 IAS price $79.99 - Item Code: 660 PABA (para-aminobenzoic acid, see Beyond Chelation Improved®, Gerovital®), Palmitate (see Beyond Chelation Improved®), Pancreatin (see Wobenzym®), Panthenol (pantothenic acid, see vitamin B5), Papain (see Beyond Chelation Improved®, Wobenzym®)

PEMF (Pulsed electronic magnetic field) Please contact us for the range of professional equipment currently available. Further details are available at www.pemf-therapy.eu

PEO (Parent Essential Oils)

NEW: PEO-Pro™ 120 capsules retail $44 IAS price $39.99 - Item Code: 995

Penicillin (Penilevel®)

Penilevel® 20x 250mg sachets powder retail $34 IAS price $29.99 - Item Code: 952

Pentavita (see Nanogen®)

Peptide Bioregulators (also see Youth Gems®)

NEW: Adrenals (Glandokort®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 853

NEW: Cartilage (Sigumir®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 893 NEW: Eyesight (Visoluten®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 856 NEW: Kidneys (Pielotak®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 869 NEW: Liver (Svetinorm®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 894 NEW: Lungs (Taxorest®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 959 NEW: Muscle (Gotratix®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 978 NEW: Pancreas (Suprefort®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 892 NEW: Pineal (Endoluten®) 20x 200mg capsules retail $99 IAS price $89.99 - Item Code: 884 NEW: Prostate (Libidon®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 854 NEW: Testes (Testoluten®) 20 x 200mg capsules retail $85 IAS price $74.99 - Item Code: 855 NEW: Thyroid (Thyreogen®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 883 NEW: Stomach (Stamacort®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 896 NEW: Heart (Cheloheart®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 898 NEW: Bladder (Chitomur®) 20 x 200mg capsules retail $85 IAS price $74.99 - Item Code: 897

NEW: Blood vessels (Ventfort®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 868

NEW: Ovaries (Zhenoluten®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 899

NEW: Brain (Cerluten®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 867

NEW: Thymus (Vladonix®) 20x 200mg capsules retail $85 IAS price $74.99 - Item Code: 882

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Phenytoin (Dilantin®, Epanutin®) Phen-Pro™ 28x 25mg capsules retail $25 IAS price $19.99 - Item Code: 786

Procaine (Novocain®, see Gerovital®, Crème-Pro™ Moisturizer)

Progesterone Phosphatidylcholine (see Beyond Chelation Improved®, Crème-Pro™ Cellulite), Phosphatidylserine (see Beyond Chelation Improved®), Phospholipids (see krill), Phosphorous (see Nitric-Pro™)

Picamilone

Pic-Pro™ 60x 50mg tablets retail $24 IAS price $19.99 - Item Code: 184

Propranolol (Inderal®)

Inderal® 30x 40mg tablets retail $25 IAS price $19.99 - Item Code: 34

Prostate-Pro2™

NEW: Prostate-Pro2™ 60 capsules retail $35 IAS price $29.99 - Item Code: 871

Pimagidine (see aminoguanidine)

Piracetam (also see Anacervix®) Nootropil® 20 grams 100ml liquid retail $25 IAS price $21.49 - Item Code: 50 Nootropil® 60x 800mg tablets retail $30 IAS price $27.99 - Item Code: 205 Pira-Pro™ 100x 800mg tablets retail $24 IAS price $17.99 - Item Code: 873 Polyphenols (see grape seed extract), Pomegranate extracts (see Andro-Pro™), Potassium (see Beyond Chelation Improved®, Gerovital®), Potassium iodide (see ACF228™), Potassium iodine (see ACF228™)

PQQ (pyroloquinoline quinone)

NEW: PQQ-Pro™ 30x 20mg capsules retail $40 IAS price $35.99 - Item Code: 837

Pueraria mirifica (see HRT Plus®), Pulsed electronic magnetic field (see PEMF) Pulsed magnetic therapy (PMT, see PEMF), Pygeum africanum (see Nanogen®, Prostate-Pro2™)

PulmoLife® (FVC biological age)

PulmoLife®1 Spirometer + 4 tubes retail $160 IAS price $139.99 - Item Code: 781 PulmoLife®25 additional tubes retail $25 IAS price $19.99 - Item Code: 782

Pyridoxamine

Pyri-Pro™ 60x 50mg tablets retail $39 IAS price $32.49 - Item Code: 449

Pyritinol

Cerbon 6® 60x 100mg tablets retail $29 IAS price $24.99 - Item Code: 167

Pramiracetam

PramPro™ 40x 300mg tablets retail $60 IAS price $49.99 - Item Code: 451

Pregnenolone

Progesterone 50ml 2.5 grams (5%) cream retail $35 IAS price $29.99 - Item Code: 789

PregPro™ 50x 100mg capsules retail $25 IAS price $21.49 - Item Code: 335

Pyroloquinoline quinone (see PQQ), Quercetin (see Digestif®)

Rasagiline

NEW: Rasagiline-Pro™ 30x 1mg capsules retail $95 IAS price $89.99 - Item Code: 827

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Reboxetine (Davedax®)

Edronax® 60x 4mg tablets retail $70 IAS price $64.99 - Item Code: 22

Red algae (carrageenan, see Beyond Chelation Improved®), Red clover herb extract (see Prostate-Pro2™), Red yeast (see Beyond Chelation Improved®)

Releasing-Pro™ (GHRP6)

NEW: Releasing-Pro™ 5ml 500IU nasal spray retail $89 IAS price $79.99 - Item Code: 904

Reminyl® (see Galantamine)

Resveratrol (also see ACF228™, Beyond

Chelation Improved®, Crème-Pro™ Protector, MinSaw™, Resveratrol-Pro™) NEW: Resveratrol-SR™ (slow release) 30x 150mg capsules retail $34 IAS price $29.99 - Item Code: 983

Retin-A®

Retirides® 30ml 0.025% cream retail $39 IAS price $29.99 - Item Code: 254 Retirides® 30ml 0.050% cream retail $49 IAS price $39.99 - Item Code: 764 Retirides® 30ml 0.100% cream retail $59 IAS price $49.99 - Item Code: 74 Retin-A® 20ml 0.100% micro-gel retail $80 IAS price $74.99 - Item Code: 744

Retinolic acid (tretinoin, see MinSaw™, Retin-A®), Ribonucleic acids (RNA, see Cerebrolysin®, NeyDent®), Ribose (see Bio-En’R-Gy®), Rice bran husks (see Beyond Fiber®), R-lipoic acid (see ATP-Boost™)

Roxithromycin

Rulid® 10x 150mg tablets retail $35 IAS price $29.49 - Item Code: 635

Rutin (see Wobenzym®), Saizen® (see HGH), Salicylic acid (see BEC5 Curaderm®, Nanogen® shampoo)

SAMe (S-Adenosyl-L-Methionine) SAMYR® 20x 400mg enteric-coated tablets retail $69 IAS price $64.99 - Item Code: 231 42

Saw palmetto (Serena repens, see MinSaw™; Nanogen®, Prostate-Pro2™)

Scalproller®

Scalproller® 0.3mm roller kit retail $75 IAS price $69.99 - Item Code: 762

Selepryl® (see deprenyl), Selegiline (see deprenyl), Selenium (see ACF228™, Beyond Chelation Improved®, Dim-Pro2™, MZS™, Prostate-Pro2™, thymus)

Sermorelin

Sermo-Pro® 30ml/ 30mg liquid bottle retail $225 IAS price $199.99 Item Code: 714

Shave grass (see Dr Gordon’s Organic Greens®), Silicon/ Silica (see Beyond Chelation Improved®; Nanogen™, Wobenzym®)

Silver protein (ACS®)

Advanced Cellular Silver 200® 2 oz. spray retail $35 IAS price $34.99 - Item Code: 596

Solasodine glycosides (see BEC5 Curaderm®), Somatomedin C (see IGF-1), Somatropin (see HGH), Spirulina (see Dr Gordon’s Organic Greens®)

Stablon® (tianeptine)

Stablon® 60x 12.5mg tablets retail $69 IAS price $62.49 - Item Code: 748

Stevia (see Dr Gordon’s Organic Greens®), Superoxide dismutase (SOD, see Nanogen® serum), Syringes (see injection packs)

TA65®

TA65® 30 capsules IAS price $218.99 - Item Code: 755 TA65® 90 capsules IAS price $599.99 - Item Code: 754

Tamanu Tamanu 50ml bottle oil retail $29 IAS price $24.99 - Item Code: 724

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Telomeres/ telomerase (see TA65®), Temple viper venom (synthetic, see Crème-Pro™ Smoother)

Tetracycline

Ambramicina® 16x 250mg tablets retail $25 IAS price $22.49 - Item Code: 143

Thymus (also see peptide bioregulator)

Thym-Uvocal® 90x 200mg capsules retail $115 IAS price $99.99 - Item Code: 691

Thyroid (also see peptide bioregulator)

NEW: Nature® 1½ grain 100x 90mg tablets retail $75 IAS price $69.99 - Item Code: 901 Nature® 2 grain 100x 120mg tablets retail $85 IAS price $79.99 - Item Code: 460

Our synthetic thyroids include: NEW: Eutirox® (T4) 100x 100mcg tablets retail $34 IAS price $27.49 - Item Code: 662 NEW: T3Pro™ (T3) 50x 20mcg tablets retail $35 IAS price $29.99 - Item Code: 960

Our natural thyroids include: Armour® 100x 15mg tablets retail $75 IAS price $69.99 - Item Code: 411 Armour® 100x 30mg tablets retail $85 IAS price $79.99 - Item Code: 468 Armour® 100x 60mg tablets retail $95 IAS price $89.99 - Item Code: 7 Armour® 100x 90mg tablets retail $135 IAS price $129.99 - Item Code: 594 Armour® 100x 120mg tablets retail $155 IAS price $149.99 - Item Code: 410 ERFA 100x 30mg tablets retail $55 IAS price $49.99 - Item Code: 736 ERFA 100x 60mg tablets retail $75 IAS price $69.99 - Item Code: 737 ERFA 100x 125mg tablets retail $95 IAS price $89.99 - Item Code: 738 Nature® 100x 15mg tablets retail $45 IAS price $39.99 - Item Code: 613 Nature® 100x 30mg tablets retail $50 IAS price $44.99 - Item Code: 324 Nature® 100x 60mg tablets retail $65 IAS price $59.99 - Item Code: 323

Thyrotropin releasing hormone (see TRH), TMG (trimethylglycine, betaine, see Beyond Chelation Improved®, Bio-En’R-Gy®), Tocotrienols (see Beyond Chelation Improved®), Tribulus terrestris (see Andro-Pro™, Beyond GHS®)

TRH (thyrotropin releasing hormone)

NEW: Abaris™ 20 x 5mg sublingual tablets retail $250 IAS price $199.99 - Item Code: 793

Trypsin (see Wobenzym®), TRX (see Hair-Pro™), Turmeric (see curcumin), Ubiquinol (see CoQ10), Ubiquinone (see CoQ10), Urea (see BEC5 Curaderm®), Urtica dioica (see Nanogen®)

Valdoxan® (agomelatine)

Valdoxan® 28x 25mg tablets retail $150.99 IAS price $144.99 - Item Code: 690

Vasopressin (also see desmopressin)

NEW: Vaso-Pro® 5 ml 500 IU nasal-spray retail $75 IAS price $69.99 - Item Code: 838

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VEGF (see Hair-Pro™, Nanogen® conditioner, Nanogen® serum, Nanogen® shampoo)

Venlafaxine (Efexor®)

Venlafaxine 60x 37.5mg tablets retail $45 IAS price $39.99 - Item Code: 488

Viagra® (sildenafil)

Viagra® 4x 100mg tablets retail $79 IAS price $69.99 - Item Code: 90

Vielight® laser

NEW: Vielight® 633 inter-nasal laser retail $300 IAS price $299.99 - Item Code: 958

Vincamine (see Anacervix®)

Vinpocetine

Intelectol® 50x 5mg tablets retail $19 IAS price $16.99 - Item Code: 91

Vitamin A (beta carotene, palmitate, see Beyond Chelation Improved®), Vitamin B1 (thiamine, see Beyond Chelation Improved®, Nitric-Pro™), Vitamin B1 (see benfotiamine), Vitamin B2 (riboflavin, see Beyond Chelation Improved®, Nitric-Pro™), Vitamin B3 (niacin, niacinamide, see Beyond Chelation Improved®, CrèmePro™ Cellulite, Nanogen® serum, Nitric-Pro™, picamilone; Xan-Pro™), Vitamin B5 (panthenol, pantothenic acid, see Beyond Chelation Improved®, Nitric-Pro™), Vitamin B6 (pyridoxine, see ACF228™, Andro-Pro™, Beyond B12®, Beyond Chelation Improved®, DIM-Pro2™, Gamalate B6®; HRT Plus®, Nanogen®; Nitric-Pro™), Vitamin B6 (see pyridoxamine), Vitamin B12 (cobalamin, see B12®, Beyond Chelation Improved®, CrèmePro™ Moisturizer, Cromatonbic®, DIM-Pro2™), Lithium, Neo40®), Vitamin D3 (cholecalciferol, see D3, Beyond Chelation Improved®, Bone-Pro2™, Prostate-Pro2™), Vitamin C (ascorbic acid, see Beyond Chelation Improved®, Bio-En’R-Gy C®, Digestif®; MinSaw™, Neo40®, Nitric-Pro™)

Vitamin C test strips (Vitacheck-C®) NEW: Vitacheck-C® 50 strips retail $18 IAS price $15.99 - Item Code: 774

Vitamin E (tocopherols, see Beyond Chelation Improved®, Can-C Plus™, DIM-Pro2™, Nitric-Pro™, Prostate-Pro2™, Resveratrol-Pro™), Vitamin K2 (menatretrenone, see Beyond Chelation Improved®, Bone-Pro2™), Wheat grass (see Dr Gordon’s Organic Greens®)

Wobenzym-N®

Wobenzym® 200 tablets retail $75 IAS price $72.49 - Item Code: 381

Xan-Pro® (xanthinol nicotinate) Xan-Pro® 50x 150mg tablets retail $24 IAS price $17.49 - Item Code: 552

Yohimbine (also see Crème-Pro™

Cellulite)

Plain Prowess® 100x 5mg tablets retail $59 IAS price $49.99 - Item Code: 94

Youth Gems® (topical peptide

bioregulators; each contains thymus, pineal, cartilage and blood vessel peptides plus ginseng) NEW: Youth Gems® 200ml bottle body milk retail $49 IAS price $44.99 - Item Code: 991 NEW: Youth Gems® 50ml pump day cream retail $69 IAS price $64.99 - Item Code: 988 NEW: Youth Gems® 30ml dropper serum retail $89 IAS price $79.99 - Item Code: 989 NEW: Youth Gems® 200ml bottle tonic retail $44 IAS price $39.99 - Item Code: 990

Zeolite

NEW: ZeoGold Enhanced® (zeolite and hydrogen) 50g powder retail $65 IAS price $64.99 - Item Code: 950

Advanced Cellular Zeolite®2 oz. spray retail $45 IAS price $44.99 - Item Code: 833 Zinc (see Andro-Pro™, Beyond Chelation Improved®, Can-C Plus™, MZS™, Nanogen® shampoo, Thym-Uvocal®) DIDN’T FIND WHAT YOU WERE LOOKING FOR? PLEASE CONTACT US WITH YOUR REQUIREMENTS.

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Condition cross reference list This cross-reference list highlights individual products that have been used to treat & prevent various aging disorders. Note: It does not mean that all these products are synergistic together.

Free radical: ACF228™ Glycation: Aminoguanidine Hayflick: L-carnosine, TA65® Membrane: Centrophenoxine Mitochondrial: Hydergine, PQQ Neuroendocrine: Metformin, TRH Rotational: Melatonin Telomeres: TA65®

Antibiotics (also see influenzas & infections) Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline

Anti-depressants (also see depression & wellbeing)

Lithium-Pro™, milnacipran (Ixel®), moclobemide (Manerix®), reboxetine (Edronax®), Stablon®, Valdoxan®, venlafaxine (Efexor®)

Anti-glycation (see AGE)

Adaptogens

HRT Plus®, maca, Quinton®

Anti-inflammatory (see inflammation)

Addison’s disease

Anti-oxidants (free radical scavengers)

ADHD (ADD, attention deficit disorder, see mental stimulants)

Anxiety (see stress)

Adrenal fatigue

ARMD (see eyesight)

Aldosterone, Peptide Bioregulator- Glandokort®

Aldosterone, hydrocortisone, Peptide Bioregulator Glandokort®

AGE (Advanced Glycated End Products, cross linking of proteins)

ACF228™, aminoguanidine, Can-C Plus™, L-carnosine, metformin, pyridoxamine

Age Related Macular Degeneration (see eyesight)

ACF228™, Active H-minus®, ATP-Boost™, Bio-En’RGy®, glutathione, idebenone, melatonin, pyritinol

Aromatase inhibitors

Anastrozole (Arimidex®), Beyond HRT®, DIM-Pro2™, progesterone

Arterial (See heart, arterial & blood) Arthritis (rheumatoid & osteo)

Gerovital-H3®, krill, Novisyn®, pregnenolone, pyritinol, SAMe, thymus, Wobenzym®

Age Related Mental Decline (see cognitive)

Asthma (see Allergies)

Aids (see HIV)

At-home therapeutic kits

Alcoholism (also see compulsive disorders) 5HTP, L-tryptophan, memantine

B-Cure® laser, Vielight® laser

Autism (also see chelation agents) Oxytocin, piracetam

Allergies

Bio-En’R-Gy C®, pregnenolone, Thymus, Wobenzym®

Back Problems (see spine)

ALS (amyotrophic lateral sclerosis, see Lou Gehrig’s disease)

Bell’s palsy

Alzheimer’s (see senile dementia)

Beta blockers

Amino acids (including di-peptides)

5HTP, ACF228™, ATP-Boost™, Beyond GHS®, L-carnosine, L-tryptophan, Nitric-Pro

Beyond B12® Propranolol

Biological age measurement Bio-CLIP™, PulmoLife®

Anabolic (see growth hormone & testosterone)

Blood disorders (see heart, arterial & blood)

Anginas (see heart, arterial & blood)

Blood pressure

Animal use

Can-C™ eye-drops, deprenyl, L-tryptophan, peptide bioregulators

Antiaging (as impacting on a particular theory of aging) Calorie Restriction: L-carnosine, metformin, resveratrol

Neo40®, Nitric-Pro™, oxytocin, propranolol, vinpocetine

Bone problems (also see joints & arthritis)

Andro-Pro™, Bone-Pro2™, Esnatri™, Peptide Bioregulator - Bonomarlot®, progesterone, SAMe, thyroid

Breathing (see Lungs)

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Cancer (also see anti-oxidants & radiation)

1st Line™, anastrozole (Arimidex®), BEC5® Curaderm, Bio-En’R-Gy C®, bromocriptine, CurcuminSR™, D3, DIM-Pro2™, HRT Plus®, laetrile, melatonin, metformin, naltrexone, progesterone, Resveratrol-Pro™, thymus, TRH, Wobenzym®

Cardiovascular (see heart & arterial disorders) Cataplexy (sudden fatigue) Adrafinil, picamilone

Cataract (also see eyesight) Can-C™, Can-C Plus™

Central Nervous System (CNS) Peptide Bioregulator - Cerluten®

Chelation agents (removing heavy metals, also see detox)

Beyond Chelation Improved®, Beyond Fiber®, Bio-En’RGy C®, centrophenoxine, Dr. Gordon’s organic greens®, L-carnosine, zeolite

Cholesterol (see blood disorders) Chronic fatigue syndrome (see mental stimulants & physical energy improvement) Cognitive (also see memory & senile dementias) Alertness: Adrafinil Creativity: Aniracetam, piracetam, pramiracetam Focus/ concentration: Deprenyl, desmopressin, phosphatidylserine, vasopressin Energy: ATP-Boost™, centrophenoxine, picamilone General support: Gerovital-H3®, vinpocetine Intelligence: Hydergine Work load: Hydergine, thyroid

Compulsive disorder treatment (also see alcoholism)

5HTP, Gamalate®, L-tryptophan, picamilone

Cortisol alteration (also see stress)

Aldosterone, fludrocortisone, GABOB, Gamalate®, hydrocortisone, Peptide Bioregulator - Glandokort®, Gerovital-H3®, phenytoin

Crohn’s disease Naltrexone

Cross linking (see AGE) Deep vein thrombosis (see frequent fliers) Dental (see teeth & gums) Depression (also see well-being & anti-depressants) 5HTP, aniracetam, ATP-Boost™, CurcuminSR™, D3, deprenyl, Gerovital-H3®, Lithium, L-tryptophan, milnacipran, picamilone, piracetam, pramiracetam, pregnenolone, SAMe, thymus, thyroid

Detox (also see chelation agents)

Bio-En-R-Gy C®, Beyond Clean®, Beyond Fiber®, DIMPro2™, Dr. Gordon’s organic greens®, zeolite

DHT alteration (dihydrotestosterone)

Dutasteride, finasteride, Hair-Pro™, MinSaw™, Nanogen’s®, Peptide Bioregulator - Libidon®, progesterone

Diabetes

Acarbose, aminoguanidine, ATP-Boost™, benfotiamine, krill, L-carnosine, metformin, Nitric-Pro™, Peptide Bioregulator- Suprefort®, pyridoxamine, TRH, thyroid

Diabetes insipidus (see urination) Diagnostic products (see at-home diagnostics and at-home test kits) Dieting (See weight loss) Digestive issues

Beyond Fiber®, Digestif®, Dr. Gordon’s organic greens®, Peptide Bioregulator - Stamakort®

DNA support (also see telomeres)

CoQ10, D3, krill, L-carnosine, Peptide Bioregulators, PQQ, Resveratrol-Pro, TA65®

Down’s syndrome

Melatonin, piracetam

Dr. Gordon’s recommended products

Beyond B12®, Beyond Chelation Improved®, Beyond Clean2®, Beyond Fiber®, Beyond GHS®, Bio En’R-Gy C®, Dr Gordon’s Organic Greens®, HRT Plus®, maca, silver protein, zeolite

Dr. Pierpaoli’s recommended products Melatonin, TRH

Dr. Wright’s recommended products Esnatri, cobalt chloride, progesterone

Energy improvement (see physical energy & mental stimulants)

Enzymes

Boluoke®, Wobenzym®

Epilepsy

GABOB, Gamalate®, phenytoin

Erectile dysfunction (also see sex-libido & premature ejaculation)

Andro-Pro™, cabergoline, Cialis®, Neo40®, Nitric-Pro™, oxytocin, Viagra®, yohimbine

Estrogen alteration (both increases & decreases)

Anastrozole (Arimidex®), cobalt chloride, DIM-Pro2™, Esnatri™, HRT Plus®, progesterone

Excitotoxins (reduction)

Deprenyl, idebenone, L-carnosine, Lithium, memantine

Eyesight (also see cataract, ARMD & glaucoma)

ARMD: MZS™ Cataracts: Can-C™, Can-C™ Plus Contact lenses: Can-C™ Dry eyes: Can-C™ General support: Aminoguanidine, Peptide Bioregulator - Visoluten®, vinpocetine Glaucoma: Can-C™ Retinal: MZS™, nicergoline, picamilone

Fertility

Melatonin, metformin, Peptide Bioregulator - Zhenoluten®, TRH

Fibromyalgia (also see physical energy & mental

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stimulants & pain relief)

1st Line, milnacipran, naltrexone, oxytocin

First Aid cabinet

1st Line™, melatonin, naltrexone, Thymus

Homocysteine (see blood disorders)

1st Line™, silver protein

Free radical scavengers (see anti-oxidants) Frequent fliers

1st Line, GABOB, Gamalate®, L-tryptophan, melatonin, Neo40®, Nitric-Pro™, picamilone, piracetam, pregnenolone, Resveratrol-Pro™, silver protein

Gastrointestinal (see digestive) Glaucoma (see eyesight)

Hormones (includes hormonal support supplements) Bio-identical: Aldosterone, Esnatri™, melatonin, MSH, oxytocin, pregnenolone, progesterone, TRH Natural (animal): Armour® thyroid, ERFA® thyroid, Nature® thyroid, thymus, vasopressin Synthetic: Desmopressin, Eutirox® thyroid, fludrocortisone, hydrocortisone, T3Pro™ Supporting agents: Peptide Bioregulators, Cobalt chloride, DIM-Pro2™, GHRP2, GHRP6, sermorelin

HRT (hormone replacement therapy for women)

Glucose control (see diabetes)

Cobalt chloride, Esnatri™, HRT Plus®, melatonin, progesterone

Glycation prevention (see AGE)

Human growth hormone (see growth hormone)

Gout

Hydrogen

Colchicine

Active H-minus®, ZeoGold Enhanced®

Growth hormone (improvement)

Beyond GHS®, bromocriptine, deprenyl, GABOB, Gamalate®, GHRP2, GHRP6, hydergine, Neo40®, NitricPro™, sermorelin, thymus, thyroid

Hair improvement

Dercos®, dutasteride, finasteride, Gerovital-H3®, HairPro™, krill, MinSaw™, Nanogen’s, Nitric-Pro™, Nizoral®

Headaches (see migraines) Health diagnostics (see at home test kits) Hearing disorders

Aldosterone, Anacervix®, fludrocortisone, nicergoline, picamilone, vinpocetine

Heart, arterial & blood (includes blood markers)

Arteries (hard): Aminoguanidine, Bio-CLIP™, BioCUFF™, L-carnosine, Resveratrol-Pro™ Blood pressure (high): Neo40®, Nitric-Pro™, Propranolol, vinpocetine Calcium: Peptide Bioregulator - Bobothyrk® Cholesterol (high): Beyond B12®, Beyond Fiber™, CoQ10, Gerovital-H3®, TRH, Xan-Pro™ Dilation (nitric-oxide): Neo40®, Nitric-Pro™, Vielight® Fibrinogen: CurcuminSR™, TRH, Wobenzym® General support: CoQ10, krill, Peptide Bioregulators Chelohart® & Ventfort®, PQQ, vinpocetine, Wobenzym® Glucose (high): Acarbose, metformin, TRH Glycated end-products: Aminoguanidine, metformin Heart pulse (irregular): ATP-Boost™, Bio En’R-Gy C®, thyroid Heavy metals (chelate): Beyond Chelation Improved®, Beyond Fiber®, Bio En’R-Gy C® Hemorrhoids: Nitric-Pro™ Homocysteine: Beyond B12®, Beyond Chelation Improved®, Bio En’R-Gy C®, TRH Lipofuscin: Centrophenoxine Plaques (clots): Boluoke® Triglycerides: Bio En’R-Gy C®, CurcuminSR™, krill, TRH

Hepatitis (see liver and infections) Herpes (also see anti-biotics)

HIV (also see immune system improvement)

Hypertension (see blood pressure) Immune system improvement (also see infections) 1st Line™, ATP-Boost™, Beyond B12®, L-carnosine, maca, melatonin, Peptide Bioregulator- thymus (Vladonix®), Peptide Bioregulator- thyroid (Thyreogen®), pyritinol, Resveratrol-Pro™, thymus, thyroid

Infections (also see immune system improvement, anti-biotics & influenzas) 1st Line™, fluconazole, silver protein, Wobenzym®

Inflammation (reduction)

Beyond Chelation Improved®, Bio-En’R-Gy®, Boluoke®, CurcuminSR™, Digestif®, Dr. Gordon’s organic greens®, krill, maca, pregnenolone, thymus, Wobenzym®

Influenzas (also see anti-biotics, infections & immune system improvement) 1st Line™

Injectable products

Cerebrolysin®, Cromatonbic® (B12), Gerovital-H3®

Insulin & glucose control (see diabetes) Inter-nasal products

Desmopressin (Minirin®), MSH (MSH2-Pro™), oxytocin (Oxy-Pro™), GHRP6 (Releasing-Pro™), vasopressin (Vaso-Pro™), Vielight® laser

Intestinal flora (see probiotics) Joints (also see bones & arthritis)

Boluoke®, krill, Peptide Bioregulator- Sigumir®, Novisyn®, pregnenolone, SAMe, thymus, Wobenzym®

Kidney disorders (also see infections)

Aminoguanidine, Peptide Bioregulator - Pielotak® SAMe, TRH

Learning (also see memory & mental stimulants)

1st Line™, ACF228™, silver protein, Wobenzym®

Aniracetam, desmopressin, hydergine, piracetam, pramiracetam, vasopressin

HGH (see growth hormone) www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

Libido (see sex) Lipids (see blood disorders)

Oral health care (see teeth & gums)

Liver disorders (also see infections)

Osteoporosis (see bone problems)

CoQ10, Idebenone, Peptide Bioregulator- Svetinorm®, pregnenolone, SAMe, silver protein

Longevity enhancement (significant lifespan increases seen in animal studies)

Centrophenoxine, deprenyl, Desmopressin, melatonin

Lou Gehrig (ALS) Naltrexone, TRH

Lungs

ACF228™ Breathe-Easy, Centrophenoxine, Nitric-Pro™, Peptide Bioregulator - Taxorest®, PulmoLife®

Lupus

Milnacipran, naltrexone

Lyme’s

1st Line™, silver protein

Macular degeneration (see ARMD & eyesight) Malaria (also see anti-biotics) Memory (also see cognitive & senile dementia)

General support: Krill, picamilone, vinpocetine Imprinting (for later recall): Desmopressin, vasopressin Medium-long term: Hydergine, phosphatidylserine Short term: Aniracetam, piracetam, pramiracetam Speed of recall: Centrophenoxine, pyritinol

Menopause (see HRT) Mental stimulants (also see physical stimulants) Adrafinil, aniracetam, centrophenoxine, deprenyl, desmopressin, nicergoline, picamilone, piracetam, pramiracetam, vasopressin, Xan-Pro™

Methylation (conversion of one chemical into another inside the body)

ATP-Boost™, Beyond B12® Bio-En’R-Gy®, Boluoke®, SAMe, Wobenzym®, Xan-Pro™

Migraines (also see pain relief)

Beyond B12®, nicergoline, memantine, picamilone, Quinton®

Minerals (including trace- also see vitamins)

Beyond Chelation Improved®, Bone-Pro2™, Gamalate®, Quinton®

Mitochondrial support

ATP-Boost™, CoQ10, deprenyl, glutathione, hydergine, idebenone, PQQ, pregnenolone, SAMe

Multiple Sclerosis (also see mitochondrial support) Melatonin, naltrexone, TRH

Nail condition

Gerovital-H3®, krill

Narcolepsy (sleeping in the daytime) Adrafinil, melatonin, picamilone

Nitric Oxide release 48

Nitric-Pro™, Neo40®, Nitric Oxide saliva test strips

Pain relief

ATP-Boost™, Gerovital-H3®, memantine, milnacipran, nicergoline, oxytocin, Wobenzym®

Parasites (see infections) Parkinson’s disease (see senile dementia) Peptides

-short chain peptide bioregulators Adrenals = Glandokort®, Bladder = Chitomur® Blood vessels = Ventfort®, Bone marrow = Bonomarlot® Brain (CNS) = Cerluten®, Cartilage = Sigumir® Heart = Chelohart®, Kidney = Pielotak®, Liver = Svetinorm®, Lungs = Taxorest® Muscle = Gotratix®, Ovaries = Zhenoluten® Pancreas = Suprefort®, Parathyroid = Bobothyrk® Pineal = Endoluten®, Prostate = Libidon® Retina = Visoluten®, Stomach = Stamakort® Testes = Testoluten®, Thymus = Vladonix® Thyroid = Thyreogen® -other peptides Cerebrolysin®, GHRP2 (GHRP2-Pro™), GHRP6 (Releasing-Pro™) Sermorelin (Serm-Pro™), TRH (Abaris™)

Pets (see Animal use) Ph balance (rebalancing)

Active H-minus®, Dr. Gordon’s organic greens®, Quinton®

Photoaging (see radiation & skin problems) Physical energy improvement (also see mental stimulants)

Active H-minus®, ATP-Boost™, Beyond B12®, CoQ10, idebenone, L-carnosine, maca, PQQ, pregnenolone, SAMe, yohimbine

PMS (pre-menstrual syndrome)

Beyond B12®, krill, HRT Plus®, maca, Peptide Bioregulator - Zhenoluten®, vinpocetine

Premature ejaculation/ ejaculate (also see erectile

dysfunction & sex-libido) Oxytocin

Probiotics

Beyond Fiber®, Digestif®, Dr. Gordon’s organic greens®, Quinton®

Prostate (also see cancer)

Beyond B12™, D3, DIM-Pro2™, dutasteride, finasteride, HRT Plus®, melatonin, Peptide Bioregulators - Chitomur® & Libidon®, Prostate-Pro2™

Prolactin alteration

Bromocriptine, cabergoline, GABOB, Gamalate®

PSA (prostate specific antigen- see prostate) Radiation (see skin problems)

www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

Tanning (darkening the coloration of skin)

RNA (see DNA support)

MSH

Senile dementia (also see cognitive & memory)

Alzheimer’s: Centrophenoxine, CurcuminSR™, galantamine, hydergine, memantine, nicergoline General support: Anacervix®, aniracetam, piracetam, pramiracetam, vinpocetine, Wobenzym® Parkinson’s: Bromocriptine, cabergoline, deprenyl, rasagiline

Senility

Gerovital-H3®

Sex (libido, also see erectile dysfunction & premature ejaculation)

Andro-Pro™, deprenyl, maca, MSH, oxytocin, yohimbine

Skin problems (also see tanning)

Age: (liver) spots: Centrophenoxine Anti-glycation: Aminoguanidine, L-carnosine Anti-oxidant: Crème-Pro™ Protector Cancer (non-melanoma): BEC5® Curaderm Cellulite: Crème-Pro™ Celluless Collagen: Hy-Col™ Environmental: Crème-Pro™ Protector Fine lines: Crème-Pro™ Smoother General support: Gerovital-H3®, Quinton®, thyroid Hyaluronic acid: Hy-Col™ Infections: Silver protein, Thym-Uvocal® Moisturizer: Crème-Pro™ Moisturizer Radiation: Crème-Pro™ Protector, melatonin Scars/ stretch marks: Tamanu oil Sun spots: BEC5® Curaderm Wrinkles: Retin-A®

Sleep disorders

For less sleep: adrafinil, ATP-Boost™ For more sleep: 5HTP, gabapentin, L-tryptophan, melatonin

Smoking cessation

Teeth & gum disorders

Doxycycline, NeyDent®, silver protein, Quinton®, zeolite

Telomeres (also see DNA support) Krill, L-carnosine, TA65®

Testosterone & testes (also see fertility and prostate) Andro-Pro™, Anastrozole (Arimidex®), Beyond B12®, Beyond GHS®, DIM-Pro2™, melatonin, oxytocin, Peptide Bioregulator - Testoluten®, TRH

Therapeutic equipment (see at-home therapeutics) Thyroids

Natural brands: Armour®, ERFA®, West® (Nature®) Synthetic brands: IBSA® (T3+T4), Eutirox® (T4), Tiromel® (T3) Supporting agents: Peptide Bioregulator - Thyreogen®

Travel (see frequent fliers) Triglycerides (see blood disorders) Urination (frequent)

Peptide Bioregulator -Chitomur®, vasopressin

Veterinarian (see animal use) Vitamins (also see minerals)

Benfotiamine, Beyond B12®, Beyond Chelation Improved®, Bio- En’R-Gy C®, CoQ10, D3, GABOB, Gamalate®, Nitric Pro™, PQQ, pyridoxamine, Xan-Pro™

Water

Active H-minus®, Quinton®

Weight gain (muscle mass)

Andro-Pro™, Beyond GHS®, GABOB, GHRP6, sermorelin

5HTP

Spine Issues

Peptide Bioregulator- cartilage (Sigumir®), Novisyn®

Sports (see growth hormone, estrogen alteration, physical energy & testosterone) Stress (also see cortisol)

5HTP, GABOB, Gamalate® , Gerovital-H3®, maca, L-tryptophan, melatonin, oxytocin, picamilone, phenytoin, propranolol, pregnenolone

Stroke

Anacervix®, aniracetam, Boluoke®, hydergine, idebenone, nicergoline, Nitric-Pro™, picamilone, piracetam, PQQ, pramiracetam, pregnenolone, vinpocetine

Weight loss (Appetite suppressants and diet aids)

5HTP, acarbose, aminoguanidine, ATP-Boost™, benfotiamine, Beyond Fiber®, DIM-Pro2™, Dr. Gordon’s organic greens®, galantamine, GHRP2, L-tryptophan, metformin, MSH2, thyroid, TRH, Xan-Pro™

Well-being (also see depression)

5HTP, Active H-minus®, aniracetam, ATP-Boost™, Beyond B12®, deprenyl, Gamalate®, Gerovital-H3®, krill, L-tryptophan, melatonin, picamilone, piracetam, pramiracetam, SAMe, thymus, thyroid, Wobenzym®, ZeoGold Enhanced®

Stomach (see digestive) Sublingual products

Beyond B12™, Oxytocin (Oxy-Sub™), Sermorelin (SermPro™)

Sunburn (see radiation) Syndrome X (metabolic syndrome)

Aminoguanidine, ATP-Boost™, krill, melatonin, metformin

www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

PAYMENT OPTIONS Across the IAS websites…

Across all the IAS Group we now offer a wide variety of payment options to try and make completing your orders with us as easy as possible. Payment options available at www.antiaging-systems.com At www.antiaging-systems.com you can pay using the following methods: • Pay by VISA or JCB credit card via Unichannel • Pay using VISA credit card via Pay Gate • Purchase vouchers via Red Baron using VISA or Mastercard credit card (see the detailed explanation below for further details on how to use Pay By Voucher) • CHECK2PAY Pay using electronic check • Pay via Bank Wire (Please be aware it may take longer to process your order with this method)

Using Pay By Voucher 1. Registering The first step is to become a member of the Paybyvoucher.com website. Registration is free with no monthly or annual charges levied against your account. Please be aware that Pay By Voucher may request certain documents from you for verification purposes such as your mobile phone number. To successfully complete registration you have to confirm a One Time Pin (OTP) on the registration confirmation page. This pin will be sent to your mobile phone, so please make sure that you supply a valid mobile phone number.

2. Register your credit card For security reasons Pay By Voucher require you to register your Credit Card. Once your Credit Card is registered every purchase is directly debited against your card. Once registration is complete, you can start transacting.

3. Buying vouchers Create your own value voucher by using the buy vouchers link and entering the exact value you require and submitting your request. There is also the option to buy one of the pre-set amount vouchers but vouchers must be purchased to the specific value of the transaction otherwise the transaction cannot be successfully processed. A 36-bit unique voucher pin will then be sent to your mobile phone or email. Please copy and paste this PIN from Pay By Voucher to antiaging-systems.com. If typed you could make errors and the voucher will not process. We hope you find the guide helpful and can successfully process your transaction with us.

Payment options available at other IAS Group sites Antiaging-Nutrition.com, IASjapan.com and Antiaging-Nootropics.com now all accept payments via Visa, MasterCard, Debit Cards, American Express and PayPal.

www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

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*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

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*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

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