FRCPath Part1 Course
Liver and Pancreas MCQ 1 A 46 year old male presents with jaundice and worsening liver function tests. A cholangiography reveals beaded appearance of the bile ducts. A liver biopsy is performed, which shows portal inflammation. Periduct oedema and concentric ‘onion skin’ fibrosis is also noted. Which of the following underlying conditions is the patient most likely to have? A. Angiodysplasia of the colon B. Ulcerative colitis C. Primary biliary cirrhosis D. Wilson’s disease E. Haemochromatosis MCQ 2 A 52 year old male presents with multiple nodules in the right lobe of the liver showing enhancement in the arterial phase on CT scan. A needle biopsy of the mass shows a moderately differentiated adenocarcinoma with a tubular pattern of growth and focal clear cell change. It has the following immunoprofile: CK7 –ve, CK20 –ve, AFP –ve, mCEA – ve, canalicular positive staining for CD10 and pCEA, cytoplasmic positive staining for TTF1 and Hep Par 1 positive. What is the most likely diagnosis? A. B. C. D. E.
Fibrolamellar carcinoma Metastatic clear cell renal carcinoma Primary hepatocellular carcinoma Metastatic pulmonary carcinoma Cholangiocarcinoma
MCQ 3 A 52 year old female presents with abdominal pain and vomiting. A CT scan demonstrates a cystic lesion in the tail of the pancreas, which is excised. On gross examination the cyst is multilocular and contains seromucinous fluid. On histology, the wall of the cyst shows focal calcification and contains a cellular ovary like stroma. The surface epithelium is extensively denuded. Which of the following is the cyst most likely to represent? A. B. C. D. E.
Serous cystadenoma Mucinous cystadenoma Intraductal mucinous neoplasm Lymphoepithelial cyst Pancreatic pseudocyst
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