You are asked to provide an intraoperative opinion on a frozen section from intr-axial posterior cranial fossa tumour stained with H&E. The patient is a 6 year old boy that presented with headache and vomitting. The lesion is biphasic composed of loose microcystic and more dense areas have low cellularity, composed of elongated cells with very thin and long cystoplasmic processes with occasiaol bright red round bodies. Vascular endothelial proliferation is noted. The preferred diagnosis is:
50y old woman was admitted to hospital with seizures following 2 weeks of progressive headache. MRI scan shows non-enhancing diffusely infiltrating frontal lobe tumour. Partial lobectomy was done and histology shows a diffusely infiltrating glioma and molecular genetic was done . Which of the following molecular genetic tests confirm the diagnosis of oligodendroglioma:
MCQ 4
During a Clinico-Pathological Conference a case of Parkinson disease was discussed.A range of Immunocytochemical stains were presented. Which of the following stains will establish the diagnosis conclusively?
MCQ 5
31 year old male diagnosed with acquired immunodeficiency syndrome since age 25.
Gradual deterioration with visual loss and hemiparesis. Dies suddenly. At post-mortem, there are numerous softened coalescing lesions throughout the brain of yellowish/white colour involving the optic nerves, cortical/subcortical region and periventricular white matter. The microscopical examination showed enlarged oligodendrocytes, abnormal astrocytes and myelin pallor. What is the likely aetiology of these lesions?
Cytomegalovirus HIV Toxoplasmosis JCvirus HSVtypeII
MCQ 6
60 year old man presented with a few months history of progressive left side headache and visual impairment progressed to perminant visual loss. What is the most likley diagnosis?
Each of these individuals had a lesion in the suprasellar region. For each one select the most likely condition from the list of options. Each option should be used once only.
You have undertaken a post-mortem examination on a patient that died with a previous history of ‘dementia’. The cause of death is bronchopneumonia. For each of the following case scenarios please choose the most appropriate diagnosis.
The following are a series of case scenarios associated with the development of CNS infections. Please indicate what is the most likely aetiological agent.
