MCQ-Soft Tissue

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FRCPath Part1 Course

Soft Tissue and Bone MCQ 1 An 85 year old man undergoes a skin and soft tissue excision biopsy for an ill-defined nodule on the posterior neck measuring 4cm in diameter: Histologically the epidermis is atrophic but otherwise normal. The sun-damaged dermis shows a pleomorphic epitheloid cells with many mitotic figures which extends into the subcutaneous tissue. Focal vascoformative pattern is seen. Immunohistochemically, the tumour cells are positive for CD31, CD34 and focally for MNF116. It is negative for S100, HHV8, smooth muscle actin and desmin. The most likely diagnosis is: A. B. C. D. E.

Spindle cell carcinoma Kaposi’s sarcoma Atypical fibroxanthoma Malignant melanoma Angiosarcoma

MCQ 2 A 40 year old man with a plaque like lesion on the chest. Histology shows a dermal cellular spindle cell lesion with a storiform pattern and stains positively for CD34 and negative for CD31, EMA, SMA, Desmin and S100. No epidermal attachment is seen. The most likely diagnosis is: A. B. C. D. E.

Spindle cell carcinoma Kaposi’s sarcoma Dermatofibrosarcoma Protuberans Malignant melanoma Angiosarcoma

MCQ 3 23 year old man presents with a rapidly growing soft tissue mass on the arm. Histology shows a cellular lesion with plump fibroblast and myofibroblast-like cells with oedema and red cell extravasation. Mitoses are seen but no atypical forms or nuclear pleomorphism. What is the most likely diagnosis? A. DFSP B. MPNST C. Sarcomatoid carcinoma D. Nodular fasciitis E. Angiosarcoma

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