IHR Magazine - Winter 2019 by IHR Magazine

clinic profile

The Art and Science of Compounding Medicine

clinic profile

PUBLICATIONS M AIL 42709013 | 920 YONGE ST, SUITE 610 | TORONTO ONTARIO, M4W 3C7 | $6

Achieving Tranquility

How Swan Lake Pharmacy is transforming pain care

Soul 7 Frequency Spa Helps Your Body Heal

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WINTER 2018-2019

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Product information sheet

Probiotic IBS Support

Introduction PURICA Probiotic is designed to help people around the world who suffer the physical and psychological pain and discomfort associated with Irritable Bowel Syndrome (IBS). It is a natural solution proven to work fast to reduce abdominal pain and discomfort due to IBS, providing significant relief to most users within 15 days. It features ibSium® - the clinically-proven proprietary and dried yeast strain Saccharomyces cerevisiae (CNCM 1-3856).

How does it work? PURICA Probiotic is proven effective in reducing symptoms of abdominal pain, bloating, distension, flatulence, constipation and diarrhea and the anxiety and depression that is often related to IBS. It works on the potent strength of more than 8 billion dried yeast microorganisms per gram (8B CFU/g based on BS EN 15789:2009).

Safety US GRAS status (Generally Recognized As Safe) - FDA 21 CFR §172.896 EU QPS status (Qualified Presumption of Safety)* As for all the probiotics, the use of Saccharomyces cerevisiae is contra-indicated for those who are immunocompromised. PURICA Probiotic does not contain any GMO as defined by European Directive 2001/18/CE.

Stability The natural encapsulation process used for PURICA Probiotic has excellent stability. The finished product is stable for 24 months and no refrigeration is required, making it particularly convenient for users who travel or work long days away from home.

Recommended dosage The recommended dosage for all members of the family aged 3 and over is 500 mg twice per day. PURICA Probiotic is food grade, safe, well-tolerated and can be taken daily over the long term by anyone aged 3 or older.

Strong Clinical Support & Customer Satisfaction • 579 IBS Volunteers included in two clinical studies • Randomized, double-blind, placebo controlled trials performed according to the recommended designs of clinical trials for functional GI disorders. • Collaboration with two independent experts in gastroenterology; Pr Pierre Desreumaux and Pr Robin Spiller Customer satisfaction surveys support and validate the fast-working attributes of PURICA Probiotic. • 1161 volunteers with intestinal discomfort consuming ibSium recommended by their physicians

PURICA Probiotic IBS Support

Medicinal ingredients (per capsule) Baker's Yeast (Saccharomyces cerevisiae) .......................................... 4 Billion CFU Non-medicinal ingredients: Hypromellose Recommended use: Helps to reduce abdominal pain and discomfort associated with irritable bowel syndrome in those suffering from constipation. Source of probiotics. Recommended dose: Adults: 2 capsules daily Recommended maintenance dose: Adults: 1 capsule daily If you are on antifungal(s), take at least 2-3 hours before or after. Cautions and Warnings: If you have fever, vomiting, bloody diarrhea or severe abdominal pain, consult a health care practitioner prior to use. If symptoms of digestive upset (e.g. diarrhea) occur, worsen, or persist beyond 3 days, discontinue use and consult a health care practitioner. Contraindications: If you have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment), do not use this product. Licensed by Nutraceutical Medicine Company Inc. 6157 Scott Road • Duncan, BC, V9L 6Y8 Canada 1-877-746-9397 • service@purica.com

• 96% reported significant or moderately significant improvement with respect to gut comfort (55% significant and 41% moderate) • 77% reported relief within 15 days (and 24% within five days).

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Quench-FX™

Multi-Organ Protection 60 vegcaps/bottle – UPC 826913605756 NPN 80031616 RECOMMENDED USES: Provides antioxidants for the maintenance of good health. MEDICINAL INGREDIENTS PER 1 CAPSULE : Camellia sinensis (Green Tea Extract) (95% Polyphenols)................................50 mg Citrus aurantium (Hesperidin) ........................................................................25 mg Curcuma longa (Turmeric Extract) (95% Curcumin) ........................................15 mg R-alpha-Lipoic acid ........................................................................................50 mg Lycopersicon esculentum (Tomato Extract) (5% Lycopene) .............................10 mg Pine Bark Extract (95% Proanthocyanidins) ...................................................50 mg Sophora japonica (Quercetin) .........................................................................50 mg Tagetes erecta (Lutein)....................................................................................10 mg Vaccinium myrtillus (Bilberry Extract).............................................................25 mg Vitis vinifera (Grape Seed Extract) (95% Proanthocyanidins)........................100 mg Vitis vinifera (Red Wine Extract) (50% Polyphenols) .......................................50 mg ADDITIONAL INGREDIENT: Hypromellose (vegetarian capsule shell). RECOMMENDED DOSE: Adults: Take 1 capsule twice per day with food. CAUTIONS: Do not use if you are pregnant, breastfeeding, allergic to plants of the Asteraceae/ Compositae/Daisy family or have a bile duct obstruction. Consult a health care practitioner prior to use if you have liver disorder or develop symptoms of liver trouble, gallstones, iron deficiency, stomach ulcers, excess stomach acid, diabetes, hypertension/hypotension; taking hypoglycemic, antihypertensive, antiplatelet, or blood thinner medications. STORAGE: Store away from children. Store protected from light and moisture. ALLERGENS: Contains no corn, dairy, gluten, soy, wheat or yeast.

SinewGen™

Complex Formula for Bone, Tissue, and Joint Maintenance 250 g/bottle – UPC 826913606906 500 g/bottle – UPC 826913606951 NPN 80027398 RECOMMENDED USES: Vitamin/mineral supplement. A factor in the maintenance of good health. Vitamin C, B2, B5, B6, and Magnesium help in tissue formation. Magnesium helps to maintain proper muscle function. Calcium, Magnesium, and beta-Carotene (Provitamin A) help in the development and maintenance of bones and teeth. Vitamin C, E and Selenium are sources of antioxidants for the maintenance of good health. MEDICINAL INGREDIENTS PER 1 SCOOP (15 g): Vitamin B1 (Thiamine mononitrate) ........................................................................50 mg Vitamin B2 (Riboflavin) .............................................................................................30mg Vitamin B3 (Niacinamide) .......................................................................................250mg Vitamin B5 (D-Pantothenic acid) .............................................................................138mg Vitamin B6 (Pyridoxal 5-phosphate) ........................................................................50 mg Vitamin B9 (L-Methylfolate)................................................................................. 500 mcg Vitamin B12 (Cyanocobalamin) ............................................................................ 500 mcg Biotin ................................................................................................................... 250 mcg Choline (Choline bitartrate)....................................................................................100 mg Inositol (Myo-inositol) ...........................................................................................100 mg beta-Carotene .....................................................................................3000 mcg (5000 IU) Vitamin C ...............................................................................................................850 mg Vitamin D3 (Cholecalciferol) ...................................................................12.5 mcg (500 IU) Vitamin E (d-alpha Tocopheryl acetate).....................................................67 mcg (100 IU) Boron* (Sodium borate)....................................................................................... 345 mcg Calcium* (Calcium lactate) .....................................................................................500 mg Chromium* (Chromium polynicotinate) ............................................................... 100 mcg Copper* (Copper gluconate) ............................................................................... 1000 mcg Magnesium* (Magnesium citrate) .........................................................................150 mg Manganese* (Manganese sulphate) ..........................................................................2 mg Molybdenum* (Sodium molybdate) .................................................................... 100 mcg Selenium* (L-Selenomethionine) .......................................................................... 50 mcg Silicon* (Sodium metasilicate) .................................................................................10 mg Vanadium* (Vanadyl sulphate) .............................................................................. 25 mcg Zinc* (Zinc citrate) ...................................................................................................10 mg *All minerals are in elemental form. ADDITIONAL INGREDIENTS: D-Glucosamine hydrochloride (750 mg/scoop), Hydrolyzed collagen (6000 mg/scoop), Whey protein (1500 mg/scoop), Stevia, Natural orange flavour. RECOMMENDED DOSE: Adults: Take 1 scoop (15 g) once or twice per day with food and a few hours before or after taking other medications. Can be mixed with juice, tepid water or your favourite blender smoothie. CAUTIONS: Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Do not use if security seal is broken. STORAGE: Store away from children. Store protected from light and moisture. ALLERGENS: Contains no corn, gluten, wheat or yeast.

► Anti-Aging ► Antioxidants ► Detoxification ► Inflammation ► For organ system support (all) ► Supports glutathione and “antioxidant networks”

► Boosts the immune system ► Counteracts oxidative stress ► Provides antioxidants, reducing inflammation

► For the maintenance of bones, muscles, skin and vital tissues

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Quench-FX™

SinewGen™

9 Counteracts oxidative stress 9 Provides 11 types of antioxidants 9 All antioxidants are antiinflammatory 9 Protects tissue and organs from free radicals 9 Supports cardiovascular pathways 9 Promotes longevity and helps vision health 9 Supports immune and joint health 9 Improves insulin sensitivity and glucose tolerance

9 For anti-aging support 9 Counteracts oxidative stress 9 Provides antioxidants, reducing inflammation 9 Bioavailable hydrolyzed collagen (600 mg per scoop) 9 Whey protein for muscle strength (1500 mg per scoop) 9 D-glucosamine for joint repair (750 mg per scoop) 9 For the maintenance of bones, muscles, skin and vital tissues 9 Contains highly absorbable elemental forms of vitamins and minerals

Quench-FX™ is a unique herbal formulation containing 11 well-known antioxidants for the maintenance of good health by protecting tissue and organs from free radical damage. Used during allergy season to support the immune system. Protects most major organs including the liver, eyes, prostate, blood and cardiovascular system. Stress has a tremendous impact on the functions of the entire body and thus making us appear to age faster. The heart rate, hormonal output, and metabolism can use up the essential nutrients far too quickly thus leaving the body unprotected. Antioxidants are just one way to combat premature aging. Quench-FX™ contains green tea, hesperidin, turmeric extract, dl-alpha-lipoic acid, tomato extract, pine bark extract, quercetin, lutein, bilberry extract, grape seed extract and red wine extract.

SinewGen™ is a multi-ingredient formula containing pre-formed, bioavailable, hydrolyzed collagen in a powdered form with elemental forms of vitamins, minerals and cofactors, which are required for fast repair of any connective tissue damage. These help to encourage repair for bones, joints, sinew, and muscle functions. This complex includes whey protein, antioxidants, beta-carotene, bioflavonoids, and a broad spectrum of B vitamins and many essential minerals. A complex like this is beneficial for the maintenance of the skin, bones, tissues, joints, organs, and gland functions. SinewGen™ not only provides connective tissue factors but, it also provides a highly bioavailable multi-vitamin and mineral complex to ensure that the body is getting the appropriate nutrient load that is required for healing.

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FEATURES 12 CLINIC PROFILE: ACHIEVING TRANQUILITY By Toni-Marie Ippolito

S T

14 NEVER NETWORK AGAIN: THE ART OF UN-NETWORKING. 16 POSITIVE CHANGES ON THE HORIZON FOR HOMEOPATHIC CARE 18 CLINIC PROFILE: THE ART AND SCIENCE OF COMPOUNDING MEDICINE

By Toni-Marie Ippolito

22 STUDY: DERMATOLOGICAL EFFECTS OF NIGELLA SATIVA (BLACK SEED) 26 FOOD PRICE TO RISE IN 2019, REPORT SAYS 27 NANOPARTICLES AS REMEDIES!

N E

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28 THE IMPETUS BEHIND THE CURCUMIN

DEPARTMENTS 10 PUBLISHER’S LETTER 11

EDITORIAL BOARD

WANT TO SEE MORE? FOR EXTRA CONTENT DOWNLOAD INTEGRATED HEALTH’S DIGITAL VERSION FROM ITUNES OR GOOGLE PLAY

LETTER

ISSN 1197 - 1495 | VOLUME 19 ISSUE 3

FOUNDER & THOUGHTSMITH

Olivier Felicio SENIOR CONTENT EDITOR

Toni-Marie Ippolito GRAPHIC DESIGNER

Hugo Cukurs WEB GURU

Karl Delgadillo CONTRIBUTORS

Christophe CaÏs Denis Courschesne Sandra Shaw

PRESIDENT

Olivier Felicio GENERAL CUSTOMER CARE MANAGER

Lucy Holden

BRAVO CANADA

10 / THE HUB - IHR / WINTER 2018 - 2019

lthough the food guide is part of our landscape for just over 60 years ago, what has changed is us. It is very encouraging to see our Canadian government listing to our food habits and have adapted to it. Mostly according to NCBI the major review happened between 1987 and 1989, a lot has happened since then. Even the fast food and foodservice industry over the years has adapted to our needs, yes surely for business reasons. The Natural Health industry also has changed by providing cleaner products,

the explosion of plant-based supplement, new categories like raw foods and so for and so one. The association (CHFA) has been a pillar in expressing our voice to the better good of every Canadian, therefore, more importantly, our industry contributed to the overall social-economic changes in our food culture. Please feel free to contact me for more details

SUBSCRIPTION RATES Canada $50 (gst included) for nine issues (one year) USA $60 CHANGE OF ADDRESS email: circulation@thergmgroup.net telephone: 416-203-7900 fax: 416-703-6392 or send your cover label and new address to Integrated Health c/o IHR Magazine 920 Yonge Street, Suite 610 Toronto, ON Canada M4W 3C7

ADVERTISING INFORMATION

Olivier Felicio

T: (416) 203-7900 x 6107 E: olivier@rivegauchemedia.com

Olivier Felicio

Publisher/Editor-in-Chief Published by Rive Gauche Media Inc. Canada Post Canadian Publications Mail 42709013 The publisher does not assume any responsibility for the contents of any advertisement and any and all representations or warranties made in such advertising are those of the advertiser and not of the publisher. The publisher is not liable to any advertiser for any misprints in advertising not the fault of the publisher and in such an event the limit of the publisher’s liability shall not exceed the amount of the publisher’s charge for such advertising. No portion of this publication may be reproduced, in all or part, without the express written permission of the publisher. All rights reserved. ©Copyright 2018 Rive Gauche Media Inc.

❱ FIND US ON

ihr magazine is pleased to review unsolicited submissions for editorial consideration under the following conditions: all material submitted for editorial consideration (photographs, illustrations, written text in electronic or hard copy format) may be used by ihr Media Inc. and their affiliates for editorial purposes in any media (whether printed, electronic, internet, disc, etc.) without the consent of, or the payment of compensation to, the party providing such material. Please direct submissions to the Editor, ihr magazine.

EDITORIAL BOARD

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The purpose of our editorial board is to help guide the direction of the publication in a manner that a) improves its quality and rigor, b) exerts a positive impact on patient outcomes, c) contributes to knowledge of integrative health-care, and d) showcases evolving trends in the health-care industry. We believe that our unique blend of readers dictate the tone of our magazine, which allows us to provide you with the most accurate, up-to-date, and essential information relevant to your business. Our editorial committee is comprised of thought provokers who have shaped the industry and whose experience is vital in providing you with the tools to succeed.

DENIS COURCHESNE

DANIEL DERESER

KEN DIXON

Denis Courchesne has a solid background in sales and marketing working for companies such as Mosaic, Evian, Cadbury Adams, Bioforce Canada and Purity Life Health Products. He is president of Quebec Contact Inc., a consultancy firm dedicated to helping clients successfully develop and grow business in the Quebec market. After evolving and advancing his knowledge working in the natural product industry for over 17 years, Denis shares his experience and observations of the trade in Quebec with our readers.

Daniel Dereser, a Doctor of Pharmacy in France, received his degree from Université Aix-Marseille II in 2003 and a training certificate in clinical homeopathy for pharmacists through the Center for Education and Development of Homeopathy (CEDH). Before becoming the CEO of Boiron Canada in 2015, Dereser held the position of director of medical development for Boiron Canada and Boiron U.S.A. He also serves on the board of directors of the Canadian Homeopathic Pharmaceutical Association (CHPA).

Ken Dixon is currently the general manager for Prime Nutrisource and NüGale Pharmaceutical. Having studied business and horticulture at the Algonquin College of Applied Arts and Technology, he always had a passion for the natural nutrition industry. Now with over 20 years of business development, account management, and sales and marketing experience, his expertise in the industry is well-known and respected.

DAVID FOREMAN

MIKE HANNALAH

LEWIS RETIK

David Foreman RPh, is a pharmacist, author and media personality known to consumers nationwide as, “The Herbal Pharmacist.” Foreman is a graduate of the University of South Carolina College of Pharmacy, currently serves on Organic & Natural Health Association’s Scientific Advisory Board, and is author of 4 Pillars of Health: Heart Disease.

With experience in both the professional and regulatory sectors of pharmacy, Mike Hannalah holds a comprehensive knowledge and understanding of the unique needs, challenges and opportunities of pharmacists in Ontario. Currently, he is the director of Smith’s Pharmacy in Toronto, and is a council member of District M at the Ontario College of Pharmacists.

Lewis Retik is the leader of the Advertising & Product Regulatory group and co-leader of the Food & Beverage group at Gowling WLG. As a partner in Gowling WLG’s Ottawa office, he practices primarily in the area of regulatory and commercial law. Lewis’ practice focuses on regulated products, including product distribution, manufacturing, advertising, packaging and labelling, and regulatory licensing.

CLINIC PROFILE

ACHIEVING TRANQUILITY SOUL 7 FREQUENCY SPA HELPS YOUR BODY HEAL By Toni-Marie Ippolito

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eed some time to de-stress and refocus? Soul 7 Frequency Spa tunes your body so that it can function in an optimal state. When we often hear about “alternative” healing methods, many people are skeptical about their effectiveness in helping the body. Turns out, alternative methods may not be a bunch of hooey after all. Soul 7 in Toronto is one of those calm, meditative healing spas you can guarantee leaving with a calm sense of self and mind.

WHAT IS SOUL 7 FREQUENCY SPA? Soul 7 is a Frequency Spa, a new evolution of the traditional spa that integrates Pulsed Electro-Magnetic Field frequency technology (PEMF) to detox,

cleanse, reduce stress, boost energy and your immune system, enhance focus, productivity, and sleep—all designed for optimal self-care. It was founded by a former lawyer, Bob Berman, who was inspired to create the centre after losing his wife to cancer. Throughout that struggle, he explored many alternative-healing methods that took him on a journey around the world in search of the ideal blend of healing technologies. “To heal naturally, we need to balance the sympathetic and parasympathetic energies of our nervous system,” says Berman. “It is all about energy flow the body, so it can heal itself. One can achieve that Flow State in multiple ways. Our Mindful Healing Technologies help that process.”

WHAT IS PULSED ELECTROMAGNETIC FIELD (PEMF)? Soul 7 uses what they call “Mindfulness Technologies” that are designed to nourish your mind, body & soul. They work synergistically to balance the nervous system, boost the immune system and transform one’s state of mind. Each of the treatments at Soul 7 uses PEMF, (Health Canada approved) which helps to stimulate healthy cells. PEMFs work to help: • Reduce pain, inflammation, the effects of stress on the body, and platelet adhesion. • Improve energy, circulation, blood and tissue oxygenation, sleep quality, blood pressure and cholesterol levels,

CLINIC PROFILE

Studies have shown that vibrations stimulate the nervous systems, which control the brain and muscular function. When sound and PEMF are synchronized they cause the body to focus, which clears the mind and naturally relieves tension.

HERE ARE THE SOUL 7 FREQUENCY SPA PROGRAMS IN DETAIL: Detox & Cleansing: Everything from the food you eat, exposure to second-hand smoke and heavy metals will impact cellular health. These harmful toxins affect the body’s ability to cleanse and renew. This program prescribes frequencies to detox your body cell by cell and removes harmful toxins from your major organs.

First 30 minutes: focuses on mentally detoxing the mind from toxic thought patterns using specially designed sound and light brainwave entrainment along

with Health Canada Approved, Pulsed Electro-Magnetic Field Therapy. Second 30 minutes: RIFE frequencies are combined with full body vibrations to detox the body of harmful toxins. The session concludes with the U.S Military-inspired Bio-Photon Analyzer designed to tune up your biofield through a resonant effect that harmonizes your cells. Stress Relief: With this session, you will enjoy a sense of calm and relaxation as if you spent a day at the beach! This program combines sound, light and PEMF to balance the nervous and boost the immune system for optimal Stress Relief. First 30-minutes: Combines state-of-the-art, PEMF, and Physio-Acoustic Vibration. This dynamic Frequency duo begins the process of rewiring your brains response to stress by decluttering your mind and crystallizing your thought process. Second 30-minutes: Releases tension, tightness, and blockages that are preventing you from full body stress relief. It uses a Syogra warming jade massage technology to emulate the benefits of traditional shiatsu style therapy along with audio-visual frequencies to optimize stress relief.

Energy & Immunity Boost: Cellular energy comes from the mitochondria, which are the powerhouse cells within the body. Work and lifestyle factors can drain these cells leaving you feeling depleted and drained. This program combines PEMF, MWO (Multi-Wave Oscillator better known as Tesla coils), sound and light to boost and recharge your cells.

First 30-minutes: Combines state-of-theart PEMF technology and multi-wave oscillation frequencies to prime the cells while simultaneously recharging them. Second 30-minutes: Recharges the brain uses a cutting-edge electrostimulation technology designed to rewire your brainwave state.

Sleep Well: Sleep is vital for physical and mental health. You need a good night’s sleep to repair, recharge, and renew. This program uses evidence-based frequency to regulate your circadian rhythm for optimized quality of sleep. First 30 minutes: Uses PEMF technology to stimulate the body into a relaxed, restful state so you can prepare for a perfect night’s rest. Second 30 minutes: Experience the future of meditation in a state-of-the-art Neuropod. This specially designed pod uses a unique combination of vibrantacoustic stimulation with Soul 7 curated guided meditations specially designed to calm the body and mind. Focus & Productivity: Through close collaboration with a select group of worldrenowned scientists and performance experts, Soul 7 has curated the ideal combination of Brain Optimization Technologies. First 30-minutes: Combines PEMF technology and applies focused protocols stimulating the right and left hemisphere of the brain. This results in a harmonious state of consciousness commonly associated with extreme mental clarity. Second 30-minutes: Uniquely combines Mind Alive Technology and Neuromuscular Vibration. This allows the mind and body to enter a state of relaxed clarity to ensure the results of the session stick with you for the rest of the day.

FOR MORE INFORMATION ABOUT THESE, AND OTHER SERVICES VISIT SOUL 7.CA

13 / THE HUB - IHR / WINTER 2018 - 2019

the uptake of nutrients, cellular detoxification and the ability to regenerate cells. • Balance the immune system and stimulate RNA and DNA. • Accelerate repair of bone and soft tissue. • Relax muscles.

FEATURE

NEVER NETWORK AGAIN: THE ART OF UN-NETWORKING.

14 / THE HUB - IHR / WINTER 2018 - 2019

etworking is dead. It doesn’t work. The days of firehosing and spitting out every single detail, award and certification in 30 seconds or less are over. If you think this type of networking works, if you are stilling doing it – stop! Immediately. The bottom line: no one cares that much about you, well, besides you and your parents. According to Merriam-Webster the definition of networking is: 1 : the exchange of information or services among individuals, groups, or institutions specifically : the cultivation of productive relationships for employment or business.

We are moving away from the first point of a straight exchange of information (un-networking) and focusing on the second part: cultivation of productive relationships. It’s about connecting. I call it the ABC’s: Always Be Connecting. Not Always Be Closing with your 30 second elevator pitch. If you’re going into a networking setting with a mindset to quickly get through as many people as possible and get as many cards as possible, then you’ll attract the exact same people to you. They’ll be trying to go through the numbers just as fast or even faster than you. It almost feels

like a competition. When you collect lots of cards, at the end of night do you really remember each person who gave it to you? What is your follow-up with each person? Nine times out of ten, nothing meaningful happens from the connection. Sounds familiar? (Where is your deck of business cards and are they just gathering dust?). In a networking setting, you need to stop being the giver. What I mean by that is stop trying to give your pitch to everyone in the room. Focus on being a receiver and a relationship builder. Genuinely ask about the other person and their business,

FEATURE

the type of clients they are looking for and how you can help. Choose to stand out from the typical: my name is… I do x-y-z verbal diarrhoea. The goal of “un- networking” is to meet people in a genuine way, be your unique self, build rapport and get permission to connect with them outside of the networking session. Who you are “being” is exactly who you will attract. Be the person you would hire, be the person you would love to send referrals to, be the person you would welcome the opportunity to work with. Let me set the stage for you: If you had a company in which you were the CEO, and you were hiring for the role of COO, what would you expect and want from that person. Make a list of those attitudes, attributes, personality traits and skill sets.

NOW ASK YOURSELF: ARE YOU THAT PERSON? Because...if you wouldn’t work with, refer or hire YOU, neither will anyone else. Here are the 3 steps that you can take to un-network:

Go in with a plan. A plan that consists of connecting with a handful of people instead of everyone. It’s easy to remember someone who engaged you in a meaningful conversation opposed to remembering your 15th shallow conversation.

2 3

Ask open ended questions instead of closed ones. Open ended questions allow for deeper answers with more

Only take the other person’s card if you’re going to use it. When I say use it, I mean use it for yourself or to give it to someone else to forward as a referral. Now the ball is in your court, it’s time to use what I’ve shared and master the art of un-networking.

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detail.

FEATURE

POSITIVE CHANGES ON THE HORIZON FOR HOMEOPATHIC CARE

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n the homeopathic industry, great strides are being taken in Canada to help Canadians better understand the benefits of treatments. According the Daniel Dereser, CEO of Boiron Canada, Homeopathy is at a curving point where positive things are happening. “The great thing that is now happening is the creation of the Canadian National Homeopathy Association,” Dereser says. “All the provinces, which have their own homeopathy associations, will now be joined as one. The provinces have decided to combine their efforts to create one national association.” “There is a rising awareness of homeopathy happening nationwide and worldwide,” he continues. “Health care professionals, especially family physicians and nurses, are embracing integrative medicines more and more. Consumers are looking for high quality and reliable natural health products when it comes to

treatment options for themselves and their family members. Homeopathic medicines fulfill this important demand.” Dereser also says a consumer organization has been created in order to help Canadians defend homeopathy. The organization will be called “Four Homeopathy.” “They are set up and have a website,” Dereser continues. “It’s important because finally there is a consumer voice with this organization in Canada for homeopathy. This is great because the industry needs a voice on all levels, including the political level. And, Canadians need to be informed about the benefits of homeopathy.” Dereser also notes that a social media campaign will also be launched called “Homeopathy Works For Me.” The campaign, which was started in the UK, which the Canadian version will be modeled after, had over 160,000 followers. The association wants to duplicate that in Canada.

ABOUT BOIRON CANADA: Boiron is a French-based global leader in homeopathic medicines. Our laboratory operations are rooted in a proud family tradition and guided by a passion for excellence in homeopathy. Boiron Canada was established in 1988 in order to better cater to the needs of Canadian health care professionals and patients who chose homeopathic care. Located in Saint-Bruno-deMontarville, Boiron Canada’s main office was designed by architects Patrice Gamache and o. Its inspiration was derived from the very values we call our own: innovation and sophistication, discipline and passion, and performance and pleasure.

FALL 2016 / VIVAMAGONLINE.COM

CLINIC PROFILE

THE ART AND SCIENCE OF COMPOUNDING MEDICINE HOW SWAN LAKE PHARMACY IS TRANSFORMING PAIN CARE THROUGH COMPOUNDING MEDICINE by Toni-Marie Ippolito

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“

We’re trying to get people off of pain pill medication,” is not a statement you would normally associate with a pharmacy. Most pharmacies are in the business of distributing pills and the medications you need to help with whatever ails you. But in the case of Swan Lake Pharmacy, located in Markham, Ont., this statement is their mission. Established in 2017, Swan Lake Pharmacy was started by Lina Youssef, manager and owner, who was inspired to take her knowledge of pharmaceuticals one step further by focusing on the business of custom, compounding medicine. A graduate of Ain Shams University in her home country of Cairo, Youssef moved to Canada in 2010 and got her pharmaceutical license in 2012. After working mostly in the retail area of the pharma industry,

her interest in compounding medicine took hold after working for an organization that licensed pharmacists to practice in this area. Her business, Swan Lake Pharmacy, which has been awarded one of “The Top 3 pharmacies” in the area (according to ThreeBestRated.ca) would be built on this type of treatment.

WHAT IS COMPOUNDING MEDICINE? In a world where bespoke and customization is becoming a big trend in all areas including cosmetics, fashion, and skin care, medical prescriptions are following suit. According to the PCCA (Professional Compounding Centers of America) compounding medication “is the art and science of preparing customized medications for patients.” This is something that Swan Lake

Pharmacy is spearheading in the form of topical compounding medicinal creams to manage pain. Not only is it customized, but it can also target a specific area of pain directly where sometimes a pill cannot. “People have been very responsive to compound medicine,” Youssef says. “But this is not a new concept. These compounds have been around for years. It’s actually huge in the US, but in Canada dealing with pain treatment alternatives have been slower in terms of getting the word out. It’s just not something that is advertised or known to people.”

FROM PILLS TO CREAMS When it comes to pain management, Youssef is always learning when it comes to advancements in patient care. Which is why her pharmacy is focusing on moving

CLINIC PROFILE

patients away from addictive pain pills that often come with dangerous side effects and even overdose. “With pain pills, especially with nerve pain, it’s hard to target so it’s an ongoing issue. So, anyone using pain pills like opioids or narcotics, studies say that if you use it over a period of three months then technically you’re on it for good. You start to get a tolerance and it becomes very hard to get off of it. That’s why it’s become such an epidemic. There are huge amounts of overdosing. And we’re focusing more on that,” she says. “Also, seniors are more at risk and have more tendencies to develop side effects such as ulcers and kidney malfunction with certain medications.” Swan Lake pharmacy is hoping to change all that with compounding topical medicine to better target and manage their pain. “We’re focusing on cream medication to get patients off of pills. With compound cream, you’re getting all the medicinal ingredients you’d get in a pill but in cream form.” Patients, according to Youssef, love the idea of treating their pain topically. She says although they began mainly treating senior citizens with compounding medicine, as they got more involved she found out that pretty much nobody wants to take pills. “People are heading towards not using pills if possible,” she reveals. “For example, a patient claiming, “my ankle hurts,” from injury, would rather have a cream than a pill to treat and directly target that area.”

MORE THAN A PHARMACY This type of targeted care is what’s making Swan Lake Pharmacy a leader in this field. But Youssef humbly attributes her success to her patients. “The patients here are very

“We’re focusing on cream medication to get patients off of pills. With compound cream, you’re getting all the medicinal ingredients you’d get in a pill but in cream form.” 19 / THE HUB - IHR / WINTER 2018 - 2019

HEALTH CARE FIRST When a patient visits Swan Lake Pharmacy, they do a quick assessment and, depending on a patient’s need, a compounded topical cream is formulated. “The ingredients in the cream depends on what the patient needs it for. We can put up to five or six ingredients in it, but it’s all custom,” Youssef explains. “The more topical the better. If topical works first, that’s the way to go. All doctors are on board with this, and we work closely with the patient’s family physician to approve what we’re recommending and they can approve or adjust levels of ingredients in the compound cream. Once the formula is created, and it is doctor approved, that’s when the patients can get off their medication.”

CLINIC PROFILE

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“The ingredients in the cream depends on what the patient needs it for. We can put up to five or six ingredients in it, but it’s all custom.”

supportive. We just opened a year and a half ago and we have to thank our patients for being active and putting reviews online and coming back and giving us thanks.” When it comes to setting her business apart from others, for Youssef it’s simple. “We don’t just look at prescriptions as counting pills. When a patient comes in with a full profile from their doctor we’ll actually recommend if they need to stop other medications that may interfere with their prescription. Then, they’ll go back to their physician and end up stopping another medication because it was affecting the quality of their life. For us, it’s about looking at the full picture for patients not just the pills their taking but how their lifestyle is going.”

LOOKING AHEAD Swan Lake Pharmacy hopes to expand in the near future to include more in-house products that you can currently buy through their e-commerce store swanlakepharmacy. com (where you can buy health and wellness products from vitamins to personal care items to over-the-counter medication) and by adding a dietician for therapeutic nutrition. All around, she says that her mindset as a pharmacist is to also help change people’s lifestyle. “I just think people appreciate that we go that step further and consult with them instead of just going to any pharmacy and simply picking up their pills and getting some information about those pills and that’s it. Taking that one extra step for a patient will give you that patient’s loyalty for life.” Youssef hopes to continue to lead the way in the compounding medicine industry and continue to research to help people not only manage pain but to also focus on preventative treatments and therapy.

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STUDY: DERMATOLOGICAL EFFECTS OF NIGELLA SATIVA (BLACK SEED) ABSTRACT igella sativa seed, commonly known as black seed, has been employed as a natural remedy for many ailments for centuries in many cultures. It contains many active components including thymoquinone, thymohydroquinone, dithymoquinone, thymol,carvacrol, nigellimine, nigellicine, nigellidine and alphahederin. It was reported to possess numerous pharmacological effects

related to several organs of the body. In this article, the literature pertaining to dermatological effects of N. sativa is reviewed. To the best of our knowledge this is the first review on this subject and we expect it stimulates further studies on the dermatological effects and application of N. sativa.

1. INTRODUCTION Nigella sativa (N. sativa) belongs to the

botanical family of Ranunculaceae and commonly grows in the Eastern Europe, Middle East, and Western Asia. It is a small shrub with tapering green leaves and rosaceous white and purplish flowers. Its ripe fruit contains tiny seeds, dark black in color, known as “Habba Al-Sauda” or “Habba Al-Barakah” in Arabic and black seed in English. The seed and oil of N. sativa were frequently used in ancient remedies

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2. ANTIMICROBIAL EFFECTS 2.1. Antibacterial Topozada et al. (1965) were first to report the antibacterial effect of the phenolic fraction ofN. sativa oil. El-Fatatry (1975) isolated thymohydroquinone from the volatile oil of N. sativa, which was found to have high activity against gram-positive microorganisms, includingStaphylococcus aureus. Diethylether extract of N. sativa was reported to possess concentration dependent inhibitory effect on gram-positive bacteria (represented by S. aureus) and gram-negative bacteria

(represented by Pseudomonas aeruginosa andEscherichia coli) (Hanafi and Hatem, 1991). It also showed synergistic effect withstreptomycin and gentamycin and additive effect with spectinomycin, erythromycin,tobramycin, doxycycline, chloramphenicol, nalidixic acid, ampicillin, lincomycin and co-trimoxazole and successfully eradicated a non-fatal subcutaneous staphylococcal infectioninduced experimentally in mice when injected at the site of infection (Hanafi and Hatem, 1991). N. sativa extract showed almost similar results to topical mupirocin in the treatment ofneonates with staphylococcal pustular skin infections with no side effects (Rafati et al., 2014). Microbial resistance to drugs is a common and important issue. Studies of the effects of N. sativa extracts in vitro against resistant microorganisms, including resistant S. aureusand P. aeruginosa, showed promising and good results against many multi-drug-resistant gram positive and gram negative bacteria (Morsi, 2000, Mashhadian and Rakhshandeh, 2005, Salman et al., 2005). 2.2. Antiviral N. sativa was found to enhance helper T cell (T4) and suppressor T cell (T8) ratio and increased natural killer (NK) cell activity in healthy volunteers (El-Kadi and Kandil, 1986). Besides improvement in immunity, N. sativa extract had some inhibitory effect on the humanimmune deficiency virus protease but the active principle(s) responsible for this activity was not identified (Ma et al., 1994). Moreover, N. sativa oil when given intraperitoneally to mice infected with murine cytomegalovirus for 10 days, the virus was undetectable in the liver andspleen, while it was still detectable in the control mice. This action was considered to be related to increase in the number and function of M-phi and CD4 +ve T cells and increased production of INF-gamma (Salem and Hossain, 2000). 2.3. Antifungal Hanafi and Hatem (1991) were the first to demonstrate the inhibitory effect of the diethyl-ether extract of N. sativa extract against Candida albicans. The ether extract of N. sativawas reported to inhibit the growth of Candida yeasts in several organs in experimental animal infections (Khan et al., 2003). Thymoquinone was also shown to inhibit in vitroAspergillus niger and Fusarium solani and the activity was

comparable to amphotericin-B(Al-Jabre et al., 2003, Alqorashi et al., 2007, Randhawa et al., 2005). It was reported to be more effective than amphotericin-B and griseofulvin against Scopulariopsis brevicaulisgrowth in vitro. There was 100% inhibition of the growth of S. brevicaulis with thymoquinone 1 mg/ml, while amphotericin-B 1 mg/ml inhibited only 70% growth. However, clotrimazolewas much more effective than the above mentioned drugs, with an MIC of 0.03 mg/ml (Aljabre, 2005). The ether extract of N. sativa was found to inhibit dermatophytes isolated from sheep skin infection (Kader et al., 1995). Thymoquinone was shown to possess moderate activity against clinical isolates of the three main groups of dermatophytes: Trichophyton,Epidermophyton and Microsporum and the ether extract of N. sativa were also found to be effective but in relatively higher concentrations (Aljabre et al., 2005). The MIC of thymoquinone against various dermatophytes ranged from 0.125 to 0.25 mg/ml, while the ether extract inhibited 80–100% of the growth of most dermatophytes at 40 mg/ml. Proportionately, greater effect of thymoquinone than N. sativa extract points out to that, theantifungal activity of N. sativa is primarily due to thymoquinone (Aljabre et al., 2005). In another study also thymoquinone, thymohydroquinone and thymol demonstrated antifungal effect against many clinical isolates, including dermatophytes, molds and yeasts at a concentration of 1 mg/ml (Taha et al., 2010). Using broth microdilution assay, extract of N. sativa inhibited the growth of Madurella mycetomatis, an important causative fungus ofmycetoma, at a concentration as low as 1 μg/ml (Elfadil et al., 2015). 2.4. Antiparasitic An ointment prepared from the alcoholic extract of N. sativa seeds was applied daily for 15 weeks to cutaneous leishmaniasis produced experimentally in mice by a subcutaneous inoculation of Leishmania major at the dorsal base of the tail. The morphology of the lesion and the body weight of mice were monitored daily. There was no significant difference between the average weight of mice receiving N. sativa extract ointment and controls but the lesion diameter and symptoms of inflammation were significantly lesser in the test group as compared to the controls (Bafghi et al., 2011). N. sativa seed was tested against miracidia,

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(Unani, Ayurveda, Chinese and Arabic) in Asian countries and in the middle east. Several uses of the N. sativa seed had been mentioned by Ibne-Sina (980–1037) in his famous book Al-Qanoon fi el-Tibb (El-Kadi and Kandil, 1986, Al-Jishi, 2000). Numerous active components have been isolated from N. sativa seed and its oil includingthymoquinone, thymohydroquinone, dithymoquinone, thymol, carvacrol, nigellimine-N-oxide, nigellicine, nigellidine and alpha-hederin. The pharmacological properties of N. sativa and its ingredients had been investigated by in vitro and in vivo studies conducted on human and laboratory animals. These studies showed that N. sativa and its ingredients have a wide range of pharmacological effects; immune-stimulatory, antiinflammatory, hypoglycemic,antihypertensive, antiasthmatic, antimicrobial, antiparasitic, antioxidant and anticancer effects (reviewed in Randhawa and Alghamdi, 2002, Randhawa and Alghamdi, 2011, Ali and Blunden, 2003, Salem, 2005, Padhye et al., 2008, Randhawa, 2008). Acute and chronic toxicity studies on laboratory animals have reported that N. sativa seed, its oil and thymoquinone, the most abundant and widely studied active principle, are safe, particularly when given orally (Badary et al., 1998, Mansour et al., 2001, Al-Ali et al., 2008). The objective of this article is to review the reported dermatological effects of N. sativa. An online and PubMed search of published articles related to the dermatological effects of N. sativaseed, its oil and active ingredients was conducted. Only articles substantiated by appropriate scientific methodology were reviewed and included. The following are categories of the studies: antimicrobial, antiviral, antifungal, antiparasitic, wound healing, psoriasis, acne vulgaris, vitiligo, skin cancer, percutaneous absorption, cosmetic application and cutaneousside effects.

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cercariae and adult worms of Schistosoma mansoni and showed strong biocidal activity against all stages of the parasite, as well as an inhibitory effect on egg-laying of adult female worms, indicating an antischistosomal potential of the N. sativa (Mohamed et al., 2005). In S. mansoni experimentally infected mice, the antischistosomal activity of N. sativa oil was found to be comparable to praziquantel and when given in combination with praziquantel there was potentiation of its effect (Mahmoud et al., 2002).

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3. WOUND HEALING N. sativa seed and its oil were found to promote wound healing in farm animals (Ahmed et al., 1995). Moreover, ether extract of N. sativa seed applied topically onto staphylococcal-infected skin in mice enhanced healing by reducing total and absolute differential WBC counts, local infection and inflammation, bacterial expansion and tissue impairment (Abu-Al-Basal, 2011). Using human gingival fibroblast as a monolayer, aqueous extract of N. sativaexhibited low free radical scavenging activity and induced gingival fibroblast proliferation with accelerated wound closure activity despite its non-significant effect on collagen synthesis(Ab Rahman et al., 2014). It also resulted in elevation of basic fibroblast growth factor andtransforming growth factor beta (Ab Rahman et al., 2014). 4. ANTI-INFLAMMATORY 4.1. Psoriasis The ethanolic extract of N. sativa seed was evaluated for antipsoriatic activity in vivo by using mouse tail model for psoriasis and in vitro by using sulforhodamine B assay employingHaCaT human keratinocyte cell lines (Dwarampudi et al., 2012). Significant epidermal differentiation was produced by the ethanolic extract of N. sativa, 71.36 ± 2.64%. In the negative control the epidermal differentiation was 17.30 ± 4.09% and in the positive control (tazarotene 0.1%) was 90.03 ± 2.00%. The antiproliferant activity of the ethanolic extract of N. sativa was good, IC50 value of 239 μg/ml, as compared to that of the positive control, asiaticoside, which showed potent activity with IC50 value of 20.13 μg/ml. 4.2. Acne vulgaris In a clinical study (Abdul-Ameer and Al-Harchan, 2010), N. sativa oil lotion 10% significantly reduced mean lesion count

of papules and pustules after 2 months of therapy. In the test group, the response to treatment was graded as good in 58%, moderate in 35% and no response in 7%. The satisfaction of patients with treatment was found to be full in 67%, partial in 28%, and no satisfaction in 5%. While in the control group, the lesions showed no significant reduction after 2 months and the response to treatment was good in 8%, moderate in 34%, and no response in 58%. The satisfaction of patients with treatment in this group was full in 8%, partial in 24%, and no satisfaction in 68%. There were no side effectsin the group treated with N. sativa oil lotion 10%. The authors attributed the results to theantimicrobial, immunomodulatory and anti-inflammatory effects of N. sativa oil. The molecular mechanisms of anti-inflammatory and antioxidative activities of thymoquinone, the most abundant active principle of N. sativa had been studied. Pretreatment of female HR-1 hairless mouse skin with thymoquinone attenuated 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2). Thymoquinone diminished nuclear translocation and the DNA binding of nuclear factor-kappa-B (NF-κB) via the blockade ofphosphorylation and subsequent degradation of IκBα in TPA-treated mouse skin. Thymoquinone also attenuated the phosphorylation of Akt, c-Jun-N-terminal kinase and p38 mitogen-activated protein kinase, but not that of extracellular signal-regulated kinase-1/2. Moreover, topical application of thymoquinone induced the expression of hemeoxygenase-1, NAD(P) H-quinoneoxidoreductase-1, glutathione-S-transferase and glutamate cysteine ligasein mouse skin (Kundu et al., 2013). Similar anti-inflammatory effect of N. sativa fixed oil and thymoquinone has also been reported earlier by Houghton et al. (1995). The effect was demonstrated via the dose-dependent decrease in the formation of thromboxane B2 and leukotriene B4 showing the inhibition of cyclooxygenase and 5-lipooxygenase pathways of arachidonate metabolism in rat peritoneal leukocytes.

5. SKIN PIGMENTATION 5.1. Vitiligo Lyophilized seed extract of N. sativa and its active ingredient, thymoquinone, showed significant skin darkening on the isolated melanophores of the wall lizard (Ali and Meitei, 2011). The pigment cells when

exposed to the extract or thymoquinone responded by distinct dispersion of melanin leading to skin darkening. The melanin dispersal effect was antagonized by anticholinergic drugs, atropine and hyoscine, and potentiated by ananticholinesterase agent, neostigmine. The authors suggested that cholinergic mechanisms of muscarinic nature are involved in the melanin dispersion (Ali and Meitei, 2011). In a randomized double blind clinical study, patients applied N. sativa oil to lesions of vitiligotwice daily for 6 months had a significant decrease in the vitiligo area scoring index with no significant side effects (Ghorbanibirgani et al., 2014). 6. Hypersensitivity reactions Earlier, carbonyl fraction of N. sativa and its active components, thymoquinone and nigellone were shown to counter the manifestations of allergic reactions; inhibition of histamine release from mast cells (Chakravorty, 1993), protection from histamine-inducedbronchospasm in guinea pigs (El-Dakhakhany, 1982) and decreases in the lung eosinophilia, elevated Th2 cytokines and raised IgE and IgG1 antibodies in a mouse model of allergic asthma induced by ovalbumin (El Gazzar et al., 2006). Recently, a clinical study was conducted to compare the efficacy of Nigella, Betamethasoneand Eucerin ointments applied topically twice daily for 4 weeks in new cases of hand eczema. Changes in the severity of eczema and life quality were assessed by hand eczema severity index (HECSI) and dermatology life quality index (DLQI), respectively. Nigella and Betamethasone showed rapid improvement in the hand eczema and the quality of life as compared to Eucerin. No significant difference was detected in the mean HECSI and DLQIscores of the N. sativa and Betamethasone groups, indicating to the possibility that, N. sativa had same efficacy as Betamethasone in the improvement of hand eczema and life quality (Yousefi et al., 2013).

7. SKIN CANCERS The anticancer activity of N. sativa was revealed, for the first time, when an enhancement of the natural killer (NK) cell activity was observed in advanced cancer patients receiving multimodality immunotherapy program in which N. sativa seed was one of the components (El-Kadi and Kandil, 1986). Regarding dermatology, Salomi et al. (1991) were first to investigate the antineoplastic

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in vitro. They inhibited cell proliferation and induced cytotoxicity in A431 and Hep2 cells. These agents induced apoptosis by increasing the sub-G1 population, LIVE/DEAD cytotoxicity, chromatin condensation, DNA laddering and TUNEL-positive cells. There was also an increase in Bax/Bcl-2 ratio, activation of cell proliferation of caspases and cleavage of poly ADP ribose polymerase in the treated cells. In combination, thymoquinone and diosgenin had synergistic effects, resulting in cell viability as low as 10%. In a mouse xeno-graft model, a combination of thymoquinone and diosgenin significantly reduced tumor volume, mass and increased apoptosis (Das et al., 2012). Using an in vitro cell migration assay, Ahmad et al. (2013) found that, thymoquinone inhibited the migration of both human and mouse melanoma cells. The inhibition ofmetastasis by thymoquinone was also observed in vivo in B16F10 mouse melanoma model and was accompanied by a decrease in expression of NLRP3 (NACHT, LRR, and pyrindomain-containing protein 3) inflammasome which resulted in decreased proteolytic cleavage of caspase-1. Inactivation of caspase-1 by thymoquinone resulted in the inhibition of IL-1Î˛ and IL-18. Thymoquinone also inhibited NF-ÎşB activity in mouse melanoma cellsand reactive oxygen species and the later in turn resulted in the partial inactivation of NLRP3 inflammasome. The authors suggested that, thymoquinone can be a potentialimmunotherapeutic agent not only as an adjuvant therapy for melanoma, but also, in the control and prevention of metastatic melanoma (Ahmad et al., 2013).

8. PERCUTANEOUS ABSORPTION The effect of N. sativa oil on the percutaneous absorption of model lipophilic drug-carvedilol was investigated using excised rat abdominal skin (Amin et al., 2008). N. sativa oil in 5% v/v had high degree of enhancing permeation as indicated by transdermal flux, permeability coefficient and enhancement factor. Employing differential scanning calorimetry, Fourier transform infrared and histopathology, N. sativa oil in 5% v/v, was found to work by extracting lipids from stratum corneum and by loosening the hydrogen bonds betweenceramides with subsequent fluidization of the lipid bilayer. The increased permeability of the lipophilic drug-carvedilol was considered to be due to increased diffusivity through

the stratum corneum under the influence of N. sativa oil. It was postulated that, the higher content of linoleic acid and other unsaturated fatty acids in N. sativa oil was responsible for the enhancement of in vitro percutaneous absorption of the drug (Amin et al., 2010).

9. COSMETIC APPLICATION Using pH meter, corneometer, tewameter, methyl nicotinate model of micro-inflammation in human skin, and tape stripping of the stratum corneum, the in vivo and ex vivo properties of emulsions with the seedcake extracts of N. sativa have been evaluated (Amin et al., 2010). Emulsions with Borago officinalis, and N. sativa seedcakes significantly reduced skin irritation and improved the skin hydration and epidermal barrier function as compared with placebo. The authors suggested the potential use of seedcakes in anti-aging, moisturizing, mitigating, and protective cosmetics due to their antioxidant and anti-inflammatory activities. 10. CUTANEOUS SIDE EFFECTS Contact dermatitis developed after the application of ointment made from the N. sativa seed oil but it could have been due to some impurity in the commercial black seed oil (Zedlitz et al., 2002). Bullous drug eruption with sub-epidermal detachment and necrosis of the epidermal surface has been reported in a 53-year-old woman after 2 weeks of applying N. sativa oil to her skin and ingesting it as well (Gelot et al., 2012). 11. CONCLUSION The published original research articles on the effects of N. sativa and its ingredients strongly indicate its pharmacological potential in dermatology. Standard methods of drug development are needed to formulate topical therapy for use in dermatology. CONFLICT OF INTEREST None.

REFERENCES To check out all references of this study, visit www.ihrmagazine.com/study-dermatological-effects-of-nigella-sativa-black-seed/

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effect of N. sativa. They reported that the topical application ofN. sativa and Crocus sativus extracts inhibited two-stage initiation/ promotion of [dimethylbenz [a] anthracene (DMBA)/croton oil] induced skin carcinogenesis in mice, delayed the onset of papilloma formation and reduced the number of papillomas per mouse. Later, the protective effect of bee honey and Nigella was studied on the oxidative stress andcarcinogenesis induced by methylnitrosourea (MNU) in Sprague Dawely rats. It was observed that MNU produced oxidative stresses ranging from severe inflammatory reactionin lung and skin to colon adenocarcinoma in four out of six animals. The serummalondialdehyde (MDA) and nitric oxide (NO) were also raised. Treatment with N. sativaseed given orally protected against MNU-induced oxidative stress and carcinogenesis by 80% (12/15), whereas honey and N. sativa seed together protected 100% (12/12); and serum MDA and NO also significantly decreased in both cases compared to active controls (Mabrouk et al., 2004). In another study, antineoplastic activity of thymoquinone was investigated using mousekeratinocytes, papilloma (SP-1) and spindle-17 carcinoma cells. In SP-1 cells thymoquinone induced G0/G1 cell-cycle arrest, which correlated with sharp increases in the expression of the cyclin-dependent kinase inhibitor p16 and a decrease in cyclin D1 protein expression. While in spindle 17 cells, G2/M cell-cycle arrest was noticed, this was associated with an increase in the expression of the tumor suppressor protein p53 and a decrease in cyclin B1protein. At longer times of incubation, thymoquinone induced apoptosis in both cell lines by remarkably increasing the ratio of Bax/Bcl-2 protein expression and decreasing Bcl-xL protein. These findings support a potential role for thymoquinone as a chemopreventive agent, particularly at the early stages of skin tumorigenesis (Gali-Muhtasib et al., 2004). Antitumor activity of thymoquinone and thymohydroquinone was also demonstrated usingtumor cell lines (squamous cell carcinoma, SCC VII) and fibrosarcoma, FsaR) and murinetumor models of fibrosarcoma and squamous cell carcinoma (Ivankovic et al., 2006). Thymoquinone and diosgenin, the active ingredients obtained from N. sativa and fenugreek (Trigonella foenumgraecum), respectively, were shown to exert potent bioactivity against squamous cell carcinoma

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FOOD PRICE TO RISE IN 2019, REPORT SAYS

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he average Canadian family will pay about $400 more for groceries and roughly $150 more for dining out next year, an annual food price report predicts. Food prices will rise between 1.5 to 3.5 per cent in 2019, according to the report from researchers at the University of Guelph and Dalhousie University. That means the average family of four will spend $12,157 next year — up $411 from 2018. Vegetables will see the biggest price jumps — between four and six per cent for the category, according to the report. But the cost of meat and seafood is set to fall as consumers are adopting more plant-based diets. Canada’s Food Price Report 2019, an independent analysis produced by university researchers, predicts the price of meat will drop by up to three per cent and seafood by two per cent. “This is a bit of a risk for us … We’ve

never done that,” said Sylvain Charlebois, one of the lead researchers and a professor at Dalhousie University, referring to predicting the decline. Charlebois also says consumers are showing more interest in alternative proteins, like quinoa and lentils. “We’re seeing a gradual shift to more vegetarian and vegetable-based diets in the markets,” said Simon Somogyi, one of the lead authors of the Food Price Report The authors call this the “protein wars” with pulses and legumes replacing meat in North American diets, leading to a fall in demand for meat. In the past year, Canadians consumed approximately 94 million kilograms less beef annually, compared to 2010. Young consumers are leading the way, with 63 per cent of vegans under age 38. That could mean big changes in the tastes of young families down the road.

2019 FOOD PRICE FORECAST Bakery Goods: Dairy: Food: Fruit: Meat: Restaurants: Seafood: Vegetables:

up 3% up 2% up 2% up 3% down 3% up 4% down 2% up 6%

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NANOPARTICLES AS REMEDIES!

undoubtedly proves the capacity of water to store subtle messages. Not to mention the experiences of Fritz Albert Pop with biophotons that are actually the nano-microscopic communicating light emitted by living organisms. So many examples exist to show you that subtle communication messages like nano assays are known, recognized and studied by science. The openness of science was already more attentive in a time when financial resources were less restrictive. But for obscure reasons… and surely for reasons, a campaign of global denigration is still rife on one of the so-called controversial therapeutic options! Yet clinics around the world are using this therapeutic option successfully. The problem as any therapy is obviously failures. The failure of this technique in some cases is not higher than medical treatment failures! Is it not enough to convince you? Just think of it in these terms. Health is like in politics one makes his choice and nothing prevents to take and combine ideas of right, left and centrist!

Homeopathy! Yes, homeopathy ... rich in experience and success. Here is the example of this experiment with arnica in nano dilution (homeopathic) in vitro on macrophages1. Also look at the results in veterinary medicine, no placebo there! In India, the Banerji Clinic has been publishing incredible results on all kinds of health problems for several decades. Going from hepatitis to cancer. Germans and Swiss also have renon clinics using homeopathic remedies to treat a variety of ailments. With time, people will realize the options we have to adresss a variety of health issues. - Art is made to disturb, science reassure - Georges Braque 1917-1952

CYRIL MEYRE ND

1- https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166340 - http://www.pbhrfindia.org/

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e modernistic and especially at the forefront with a redefinition of what are the concepts of homeopathic remedies at low concentrations. We redefine and update concepts powered by new identities! Cycle, mode, evolution, transformation. And today it is necessary to redefine certain terminologies in order to make them accepted! “Nothing is lost, nothing is created, everything is transformed” Henri Lavoisier. These kind of remedies, nanoparticle remedies have been known in modern medicine for decades. The hormones that regulate our body have the ability to act at very low concentrations like some medicines and drugs that work in micrograms. As demonstrated by the Nobel Prize on the discovery of HIV Luc Montagnier, he proved that it is possible to encode an entire DNA on liquid water, but also to read the electromagnetic trace stored on the same liquid water to replicate the DNA used from the water’s memory. The research of the Japanese Masaru Emoto also on the memory of the water

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THE IMPETUS BEHIND THE CURCUMIN RESEARCH AND MEDICAL DISCOVERIES THAT CHANGES EVERYTHING WE KNOW ABOUT CURCUMIN

nitially driven by a passion to better understand nutraceuticals and nutrition in order to enhance performance during his quest to win the title of several North American bodybuilding competitions, Franco Cavaleri was struck with a serious autoimmune disease. This disease derailed Cavaleri twice with hospitalization and with a prognosis of surgical intervention with prohibitive lifestyle consequences. Although he struggled to stay healthy and stay on track with his academic and athletic careers, his struggles eventually led to desperation. In 1991 while preparing for the Mr. North America contest he was hospitalized for the first time in Vancouver’s St Paul’s Hospital. After having lost as much as fifty pounds his drug resistant condition was deemed untreatable. After much introspection Franco speculated that a specialized curcuminoid extract he had been working in the lab with and using sporadically had taken the edge off his symptoms and allowed him to cope. It wasn’t until he had stopped the treatment that he was hospitalized. He decided to decline the surgical intervention and lean on his hypothesis. His rebound to optimal health led to the win in Redondo Beach, California in 1992 – Mr. IFBB North America. After nearly 19 years of research and persistence with his unique treatment he decided to terminate the unique curcuminoid treatment that he speculated was no longer needed. Within months of running down his supply of his uniquely extracted curcuminoid compound, he was hospitalized again in 2009 with the same prognosis – drug resistant ulcerative

colitis and surgery to resect the colon as the only alternative. This time his speculation about the efficacy of the treatment and its potential role turned to conviction and back he went to successfully treat and maintain long term remission with the unique extract that took several weeks to generate. This point in time generated the impetus that changed Cavaleri’s course of research forever. He made the decision to bring the strategy to formal medical drug research. Moreover, he committed to wed his 20 years of nutraceutical research to a formal initiative to study medicine and establish a medical PhD degree in experimental medicine using this natural medicine as the study subject matter of the thesis. His practical and academic experience and honed intuition in the field converged into a powerful outcome. The research was designed to determine the pharmacological mechanisms involved in this activity; and whether or not this biological activity played the role he believed it did in disease remission. Cavaleri’s research into anti-inflammatory strategies originally used to support recovery from training, quickly became focused on better understanding the pharmacology of natural medicinal agents to rehabilitate his ulcerative colitis, without surgical intervention. Irrefutably, Cavaleri was able to overcome his disease without surgery! According to Cavaleri, the key was to isolate an extract instrumental in reducing inflammation. Cavaleri achieved efficient separation of the curcuminoids within the regular curcumin extract more than 18 years ago and with the study of the pharmacology

of each constituent independently in isolation, was eventually able to unravel the pharmacology of each constituent at a cellular and subcellular level in multiple cell lines and tissues. Over the decades his in-depth biomedical work mapped the pharmacology of these curcuminoids with regards to targeted subcellular proteins in an attempt to better understand why they worked to effect symptoms differentially. In this way, Cavaleri discovered a way to predict curcumin and curcuminoid activity and augment the curcuminoid proportions within the extract to manipulate the activity to be more target specific and reliable in terms of disease indication. The result is the new potential to design curcumin-based therapies with greater precision, with the ability to more selectively target subcellular proteins involved in development of disease symptoms and pathology, and increased efficacy by indication. These discoveries change everything we knew about curcumin setting in place a new industry standard and a new level of pharmacology for patients and consumers in need. Some of his work has been published. Some is still in peer review. Cavaleri says there is still lots of work to do; to run more bench work and clinical research to determine more accurately how these natural medicines can be used to treat specific indications. Nevertheless, for now, they will cautiously use what has been discovered, patented and recently approved by the Canadian regulatory agency (NNHPD) while they continue the research at his medical laboratory, Biologic Pharmamedical Research (www.biologic-med.com).

29 / THE HUB - IHR / WINTER 2018 - 2019

By Ivan Leonov

ESTER-C® ESTER-C® KID STIKS MONOGRAPH ESTER-C® ESTER-C®KID KID KIDSTIKS STIKS STIKSMONOGRAPH MONOGRAPH MONOGRAPH ESTER-C® ESTER-C® KID KID STIKS STIKS ESTER-C® ESTER-C® KID KID STIKS STIKS ACTIVE ACTIVE CONSTITUENTS CONSTITUENTS IN IN EACH EACH PACKET: PACKET: ACTIVE ACTIVE CONSTITUENTS CONSTITUENTS IN IN EACH EACH PACKET: PACKET: Vitamin Vitamin C (calcium C (calcium ascorbate), ascorbate), Ester-C® Ester-C® brand brand . . . . . . . . . . . . . . . . . . .250 . 250 mgmg

Vitamin Vitamin C (calcium C (calcium ascorbate), ascorbate), Ester-C® Ester-C® brand brand . . . . . . . . . . . . . . . . . . . .250 . .250 mgmg Calcium Calcium (calcium (calcium ascorbate, ascorbate, calcium calcium carbonate) carbonate) .117 .117 Calcium Calcium (calcium (calcium ascorbate, ascorbate, calcium calcium carbonate) carbonate) . hydroxide) . . . hydroxide) . . . . . . . . . . . . . . .58 .117 . . .58 .117 mgmg Magnesium Magnesium (magnesium (magnesium carbonate, carbonate, magnesium magnesium Magnesium Magnesium (magnesium Niacinamide Niacinamide . .(magnesium . . . . . . . . . . . . . . . .carbonate, . . . . carbonate, . . . . . . . . . . . . . .magnesium . . . . magnesium . . . . . . . . . . . . . . . .hydroxide) . . . . hydroxide) . . . . . . . . . . . . . . .58 . . . .5 .58 . .mg 5 mg Niacinamide Niacinamide . . acid . . .(calcium . . . . .(calcium . . . . . . . . . .d-pantothenate) . . . . d-pantothenate) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 .5 . . .5 .2 .5 .mg 5 mg Pantothenic Pantothenic acid Pantothenic Pantothenic acid acid (calcium (calcium d-pantothenate) d-pantothenate) . . . . . . . . . . . . . . . . . . . . . . . . 0 .43 . . 2 .5 . 2 .5 mgmg Riboflavin Riboflavin (riboflavin (riboflavin 5’-phosphate 5’-phosphate sodium) sodium) . 0 .43 Riboflavin Riboflavin (riboflavin (riboflavin 5’-phosphate 5’-phosphate 0 .43 . . 0 .38 0 .43 mgmg Thiamine Thiamine (thiamine (thiamine hydrochloride) hydrochloride) . sodium) . . . .sodium) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 .38 Thiamine Thiamine (thiamine (thiamine hydrochloride) hydrochloride) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 .38 0 .38 mgmg Vitamin Vitamin B6 B6 (pyridoxine (pyridoxine hydrochloride) hydrochloride) . . . . 10 . . 10 Vitamin Vitamin B6 (pyridoxine (pyridoxine hydrochloride) hydrochloride) . . 10 . 25 .mcg 10 mg mg B12B6 B12 (cyanocobalamin) (cyanocobalamin) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25 mcg Vitamin Vitamin B12 B12 (cyanocobalamin) (cyanocobalamin) 25 . . 30 25 mcg mcg Folic Folic acid acid (folate) (folate) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .30 Folic Folic acid acid (folate) (folate) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .30 30 Zinc Zinc (zinc (zinc gluconate) gluconate) . . . .2 .mcg .mg 2mcg mg Zinc Zinc (zinc (zinc gluconate) gluconate) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 . .mg 2 mg

GENERAL GENERAL INFORMATION: INFORMATION: GENERAL GENERAL INFORMATION: INFORMATION: Sisu Sisu Ester-C® Ester-C® Kid Kid Stiks Stiks is aispowdered a powdered formula formula providing providing vitamins vitamins Sisu Ester-C® Ester-C® Kid Kid Stiks Stiks is aispowdered agaps powdered formula providing providing vitamins andSisu and minerals minerals to fill to fill nutritional nutritional gaps andformula and support support hydration hydration invitamins in andchildren, and minerals minerals to fill to in fill nutritional nutritional gaps gaps andand support support hydration hydration in in children, including including those in those recovering recovering from from illness. illness. children, children, including including in those in those recovering recovering from from illness. illness.

ESTER-C® ESTER-C® BRAND BRAND VITAMIN VITAMIN C C ESTER-C® ESTER-C® BRAND BRAND VITAMIN VITAMIN Cusing Ester-C® Ester-C® calcium calcium ascorbate ascorbate is made is C made using a patented, a patented, water-based, water-based,

Ester-C® Ester-C® calcium calcium ascorbate ascorbate is made isinmade using using a patented, a vitamin patented, water-based, chemical-free chemical-free process process resulting resulting ainpH a pH neutral neutral vitamin C water-based, containing C containing chemical-free chemical-free process process resulting resulting in ainpH a threonate pH neutral neutral vitamin vitamin Cfuranone. containing C containing active active vitamin vitamin C metabolites C metabolites including including threonate and and furanone. active active vitamin vitamin C metabolites C metabolites including including threonate threonate andand furanone. furanone.

ESTER-C® ESTER-C® AND AND IMMUNE IMMUNE HEALTH: HEALTH: ESTER-C® ESTER-C® IMMUNE IMMUNE HEALTH: HEALTH: Vitamin Vitamin C isCAND highly is AND highly concentrated concentrated in white in white blood blood cells cells andand supports supports

Vitamin Vitamin C function isC highly is highly concentrated concentrated in white in white blood blood cells cells and and supports supports proper proper function of these of these cells. cells. Evidence Evidence suggests suggests that that vitamin vitamin C C proper proper function function these ofduration these cells. cells. Evidence Evidence that that vitamin vitamin C C helps helps reduce reduce theof the duration and and severity severity ofsuggests common ofsuggests common cold cold symptoms symptoms helps helps reduce reduce the the duration duration and and severity severity ofphysical common ofphysical common cold cold symptoms symptoms and and that that those those under under stress stress (particularly (particularly stresses stresses associated associated and and that that those those under under stress stress (particularly (particularly physical physical stresses stresses associated associated with with competitive competitive sports) sports) may may reduce reduce their their risk risk of common of common cold cold with with competitive sports) sports) may may reduce reduce their their riskpreventively. risk ofpreventively. common of common by by ascompetitive as much much as as 50% 50% when when vitamin vitamin C is C used is used Incold aIncold a by randomized, by as as much much as as 50% 50% when when vitamin vitamin Cclinical isC used is used preventively. preventively. Indose a of of randomized, placebo-controlled placebo-controlled clinical trial, trial, Ester-C® Ester-C® at aat aaIndose randomized, randomized, placebo-controlled clinical clinical trial, Ester-C® Ester-C® at areduce atdose areduce dose of 1,000 1,000 mgmg perplacebo-controlled per day day for for 6060 days days was was found found totrial, significantly to significantly theof the 1,000 1,000 mgmg perand per day day for for 60 days waswas found found to symptoms significantly to significantly reduce reduce thethe incidence incidence and duration duration of60 common ofdays common cold cold symptoms versus versus placebo. placebo. incidence incidence andand duration duration of common of common cold cold symptoms symptoms versus versus placebo. placebo.

ESTER-C® ESTER-C® DIGESTIVE DIGESTIVE TOLERANCE: TOLERANCE: ESTER-C® ESTER-C® DIGESTIVE DIGESTIVE Gastric Gastric sensitivity sensitivity is one is one ofTOLERANCE: the ofTOLERANCE: the most most common common concerns concerns with with

Gastric Gastric sensitivity sensitivity is one is one ofhas the of the most most common common concerns concerns with with ascorbic ascorbic acid. acid. Ester-C® Ester-C® has been been shown shown to be to be less less irritating irritating to the to the ascorbic ascorbic Ester-C® Ester-C® has has been been shown shown to be to be lessless irritating irritating the to the GI GI tract tract ofacid. acid-sensitive ofacid. acid-sensitive individuals individuals than than ascorbic ascorbic acid. acid. A clinical Atoclinical GI tract tract of of acid-sensitive individuals individuals than than ascorbic ascorbic acid. acid. A Ester-C® clinical A Ester-C® clinical trialGI trial with with 50acid-sensitive 50 acid-sensitive acid-sensitive adults adults compared compared 1,000 1,000 mg mg of of trialwith trial with with 50mg 50 acid-sensitive acid-sensitive adults adults compared compared 1,000 1,000 mg mg of Ester-C® of Ester-C® with 1,000 1,000 mg of ascorbic of ascorbic acid. acid. Patients Patients reported reported 66% 66% higher higher with with 1,000 1,000 mg ascorbic of ascorbic acid. acid. Patients Patients reported reported 66% 66% higher higher prevalence prevalence of mg epigastric ofofepigastric adverse adverse effects effects when when taking taking ascorbic ascorbic acid. acid. prevalence prevalence of epigastric of epigastric adverse adverse effects effects when when taking taking ascorbic ascorbic acid. acid.

Ester-C® Ester-C® resulted resulted in significant in significant increase increase in leukocyte in leukocyte ascorbate ascorbate Ester-C® Ester-C® resulted resulted in compared significant in compared significant increase increase in acid leukocyte in acid leukocyte ascorbate ascorbate levels levels over over baseline baseline to ascorbic to ascorbic andand placebo placebo at 2, at 4, 2, 4, levels levels over over baseline baseline compared compared to ascorbic to ascorbic acid acid and and placebo placebo at 2, at 4, 2, 4, 8, and 8, and 2424 hours. hours. 8, and 8, and 2424 hours. hours.

VITAMIN VITAMIN C AND C AND TISSUE TISSUE HEALTH: HEALTH: VITAMIN VITAMIN C AND C required AND TISSUE TISSUE HEALTH: HEALTH: Vitamin Vitamin C is C required is for for thethe proper proper formation formation of collagen, of collagen, andand

Vitamin Vitamin C protein isC required is required for thetissues. the proper proper ofincollagen, ofthe andand structural structural protein in various infor various tissues. Itformation isItformation aisfactor a factor incollagen, the normal normal structural structural protein protein in various in various tissues. tissues. isIt aiscartilage, factor a cartilage, factor in the in the normal normal development development andand maintenance maintenance of bones, ofIt bones, teeth teeth and and gums gums development maintenance maintenance of bones, cartilage, cartilage, teeth teeth andand gums gums anddevelopment and a factor a factor inand wound inand wound healing. healing.of bones, andand a factor a factor in wound in wound healing. healing.

B VITAMINS: B VITAMINS: B VITAMINS: B VITAMINS: B vitamins B vitamins areare required required for for thethe metabolism metabolism of proteins, of proteins,

B vitamins B vitamins areare required required for the metabolism metabolism ofred proteins, carbohydrates, carbohydrates, and and fats, fats, forfor for thethe the formation formation ofofred ofproteins, blood blood cells cells andand carbohydrates, carbohydrates, andand for for the the formation formation ofproper red ofproper red blood blood cells cells and and energy energy production production infats, the infats, the body, body, and and for for thethe functioning functioning of the of the energy energy production production in the body, body, andand for for thethe proper proper functioning functioning of the of the nervous nervous system. system.in the nervous nervous system. system.

MINERALS: MINERALS: MINERALS: MINERALS: Children Children have have a greater a greater raterate of fluid of fluid turnover turnover since since they they have have a a

Children Children have have a greater arate, greater rate rate of fluid of fluid turnover turnover since since they they have have higher higher metabolic metabolic rate, which which makes makes them them more more susceptible susceptible toa toa higher higher metabolic metabolic rate, rate, which which makes makes them them more more susceptible susceptible tobetobe electrolyte electrolyte imbalances. imbalances. Electrolyte Electrolyte imbalance imbalance in children in children cancan electrolyte electrolyte imbalances. imbalances. Electrolyte Electrolyte imbalance imbalance inmedications children inmedications children cancan beor be caused caused by by vomiting, vomiting, diarrhea, diarrhea, sweating, sweating, certain certain or caused caused byproblems. by vomiting, vomiting, diarrhea, diarrhea, sweating, sweating, certain certain medications medications orfluids orfluids kidney kidney problems. Body Body sizesize also also factors factors in how in how the the body body uses uses kidney problems. Body size also also factors factors in how inputting how thethe body body uses uses andkidney and theproblems. the incidence incidence ofBody electrolyte ofsize electrolyte imbalance, imbalance, putting children children influids ainfluids a andhigher and therisk the incidence incidence of Electrolyte electrolyte of electrolyte imbalance, imbalance, putting putting inform ainhelp ahelp higher risk group. group. Electrolyte minerals minerals delivered delivered in ainchildren liquid achildren liquid form higher higher riskthe risk group. group. Electrolyte Electrolyte minerals minerals delivered delivered informat ainliquid aensures liquid form form replenish replenish the body’s body’s electrolyte electrolyte levels levels and and thethe format ensures anhelp anhelp replenish replenish the the body’s body’s electrolyte levels levels andand thethe format format ensures ensures an an additional additional intake intake of fluids. ofelectrolyte fluids. additional additional intake intake of fluids. of fluids.

SWEETNESS SWEETNESS AND AND FLAVOUR FLAVOUR PROFILE: PROFILE: SWEETNESS AND AND FLAVOUR FLAVOUR PROFILE: PROFILE: TheSWEETNESS The powder powder blend blend is sweetened is sweetened with with D-fructose D-fructose andand Stevia Stevia leafleaf

The The powder powder blend blend isflavours sweetened isflavours sweetened with with D-fructose D-fructose and and Stevia Stevia leafleaf powder powder andand natural natural andand extracts extracts areare used used for for flavouring. flavouring. powder powder and and natural natural flavours flavours andand are used used for20 for flavouring. flavouring. Each Each Ester-C® Ester-C® Kid Kid Stik Stik contains contains 5extracts g5extracts of g sugar ofare sugar and and 20 calories. calories. Each Each Ester-C® Ester-C® KidKid StikStik contains contains 5 g5of g sugar of sugar andand 2020 calories. calories.

DOSE DOSE AND AND DIRECTIONS: DIRECTIONS: DOSE DOSE AND AND DIRECTIONS: DIRECTIONS: Children Children (2-8 (2-8 years): years): 1 packet 1 packet perper dayday or as or as directed directed by by a health a health

Children Children (2-8 (2-8 years): years): 1 packet 1 packet per(9-13 per day day or as or 1as directed a times health a per health care care practitioner. practitioner. Adolescents Adolescents (9-13 years): years): packet 1directed packet 2bytimes 2by per dayday care care practitioner. Adolescents Adolescents (9-13 (9-13 years): years): 1 packet 1 packet 2food. times 2food. times per per or as or practitioner. as directed directed by by a health a health care care practitioner. practitioner. Take Take with with Take Take aday aday or as orhours as directed directed by by a health a health care care practitioner. practitioner. Take Take with with food. Take Take a a few few hours before before or after or after taking taking other other medications medications or natural or food. natural health health fewproducts. few hours hours before before ora after or taking other other medications medications or natural or natural health health products. Mix Mix with with glass a after glass oftaking water. of water. products. products. MixMix with with a glass a glass of water. of water.

THERAPEUTIC THERAPEUTIC EFFECTS: EFFECTS: THERAPEUTIC THERAPEUTIC EFFECTS: EFFECTS: Source Source of vitamins of vitamins and and minerals, minerals, factors factors in normal in normal growth growth andand Source Source of vitamins of vitamins andand minerals, minerals, factors factors in normal in normal growth growth andand development. development. development. development.

ESTER-C® ESTER-C® RETENTION: RETENTION: ESTER-C® ESTER-C® RETENTION: RETENTION: Leukocyte Leukocyte ascorbate ascorbate levels levels reflect reflect thethe body’s body’s cellular cellular vitamin vitamin C C

Leukocyte Leukocyte levels levels reflect reflect thethe body’s body’s cellular cellular vitamin vitamin C C stores. stores. In aInascorbate double-blind, aascorbate double-blind, placebo-controlled, placebo-controlled, cross-over cross-over clinical clinical stores. stores. In a In double-blind, a double-blind, placebo-controlled, placebo-controlled, cross-over cross-over clinical clinical trialtrial with with 1,000 1,000 mgmg of Ester-C®, of Ester-C®, ascorbic ascorbic acid, acid, or placebo, or placebo, taking taking trialtrial with with 1,000 1,000 mgmg of Ester-C®, of Ester-C®, ascorbic ascorbic acid, acid, or placebo, or placebo, taking taking REFERENCES REFERENCES •REFERENCES •REFERENCES Cochrane Cochrane Database Database Syst Rev. Syst2007 Rev. 2007 Jul 18;(3):CD000980 Jul 18;(3):CD000980 • • • • • • • • • • • • • • •

• J Circulation J Circulation 2003 2003 • Cochrane Cochrane Database Database Syst Rev. Syst2007 Rev. 2007 Jul 18;(3):CD000980 Jul 18;(3):CD000980 • JColl JJ Am Nutr. Coll 2004 Nutr. 2004 Apr;23(2):141-7 Apr;23(2):141-7 • J Am Circulation Circulation 2003 2003 • Arch Ophthalmol. 2000 2000 Nov;118(11):1556-63 Nov;118(11):1556-63 • Ophthalmol. JArch Am JColl AmNutr. Coll 2004 Nutr. 2004 Apr;23(2):141-7 Apr;23(2):141-7 • Ophthalmol Arch Arch Ophthalmol. Ophthalmol 2003;121:1621-4. • Ophthalmol. Arch Arch 20002003;121:1621-4. 2000 Nov;118(11):1556-63 Nov;118(11):1556-63 • Bernal, Bernal, S. etOphthalmol al. S. Vitamin et 2003;121:1621-4. al. Vitamin C uptake C uptake in White in White BloodBlood Cells Cells • Ophthalmol Arch Arch 2003;121:1621-4. in Vivo. in 2006. Vivo. 2006. • Bernal,Bernal, S. et al. S. Vitamin et al. Vitamin C uptake C uptake in White in White BloodBlood Cells Cells • Gruenwald, Gruenwald, et al. J. 2006. et al. 2006. SafetySafety and Tolerance and Tolerance of of in Vivo. in 2006. Vivo.J.2006. ® ® Ester-C compared with regular ascorbic acid. acid. • Ester-C Gruenwald, Gruenwald, J. compared et al. J. with 2006. et al.regular 2006. Safety Safety andascorbic Tolerance and Tolerance of of Advances Advances in Therapy. in Therapy. 23(1): 23(1): Jan-Feb: Jan-Feb: 171-8. 171-8. ® ® Ester-C Ester-C compared compared with regular with regular ascorbic ascorbic acid. acid. • Mitmesser Mitmesser Combs Combs M, Evans M, Evans M.Jan-Feb: Determinations M. Determinations Advances Advances inS,Therapy. inS,Therapy. 23(1): 23(1): Jan-Feb: 171-8. 171-8. of of • Mitmesser Mitmesser S, Combs S, Combs M, Evans M, Evans M. Determinations M. Determinations of of

@sisuvitamins @sisuvitamins sisu.com sisu.com | sisuvitamins 1.800.663.4163 | sisuvitamins 1.800.663.4163 @ @ sisu.com sisu.com | 1.800.663.4163 | 1.800.663.4163

• • • • • •

plasma plasma and leukocyte and leukocyte ascorbate ascorbate concentrations concentrations in a randomized, in a randomized, double-blind double-blind trial. FASEB trial.ascorbate FASEB Journal. Journal. 2014concentrations 2014 Apr; vol Apr; 28 28 1 plasma plasma and leukocyte and leukocyte ascorbate concentrations invol anorandomized, in1 anorandomized, supplement supplement 830.3. 830.3. double-blind double-blind trial. FASEB trial. FASEB Journal. Journal. 2014 2014 Apr; vol Apr; 28vol no28 1 no 1 Van• Straten, Van Straten, M et al. M 2002. et al. 2002. Preventing Preventing the common the common cold with coldawith a supplement supplement 830.3. 830.3. vitamin vitamin C Straten, supplement: supplement: a double-blind, placebo-controlled placebo-controlled survey. survey. • Straten, Van Van MC et al. M 2002. et aal.double-blind, 2002. Preventing Preventing the common the common cold with cold awith a Adv Ther Adv Ther May-Jun: May-Jun: 151-9. 151-9. placebo-controlled vitamin vitamin C19(3): supplement: C19(3): supplement: a double-blind, a double-blind, placebo-controlled survey.survey. • Verlangieri, Verlangieri, Anthony. Anthony. Acute Acute study study to determine to determine the Relative the Relative Rate Rate Adv Ther Adv19(3): Ther 19(3): May-Jun: May-Jun: 151-9.151-9. of Absorption of Absorption andAnthony. Excretion and Excretion of U.S.P. U.S.P. Calcium Calcium Ascorbate Ascorbate and • Verlangieri, Verlangieri, Anthony. Acute Acute study study toofdetermine to determine the Relative the Relative Rateand Rate ® ® Ester-C Ester-C Calcium Calcium 1988. 1988. of Absorption of Absorption andAscorbate. Excretion andAscorbate. Excretion of U.S.P. of U.S.P. Calcium Calcium Ascorbate Ascorbate and and ® ® • Wright, Wright, et al. A et Human al. A Human Clinical Clinical Study Study of Ester-C of Ester-C vs. vs. ®Jonathan ®Jonathan Ester-C Ester-C Calcium Calcium Ascorbate. Ascorbate. 1988.1988. L-Ascorbate L-Ascorbate Acid. Acid. 1987 1987 ® • Wright, Wright, Jonathan Jonathan et al. A et Human al. A Human Clinical Clinical StudyStudy of Ester-C of Ester-C vs. ® vs. L-Ascorbate L-Ascorbate Acid. Acid. 1987 1987

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