INNOLAB magazine #16.93

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RICE Standards in the No-Political Context

MYCOTOXIN Tests for Animal Feed

Healthy PLANT-BASED DIET for Health

Emulation an Ecosystem for a MULTI-OME SKIN PROTECTION

Bead Homogenizer
FC5816R
FC2706
FC2516
Vortex Mixer
Dry Block Heater
Overhead Stirrer
G3000
AB41PH
AB33M1
Multitube Vortex
Shaker

TRIBOGEAR Series

Surface Property Tester Type: 14FW

Multiple funtions incorporated into one unit, resolving issues in various study subjects.

Heidon Trobogear

Friction and Wear Tester

Portable Friction Meter

Tactile Meter

Surface Property Tester

Help Customers:

Improved Product Durability

Enhanced Product Quality

Lower Production Cost

Increase Product Competitiveness

Optimize Product Design

Heidon Three-one Motor (Agitator)

DC Brushless Motor

Feedback

LCD Display

Timer

Safety: Current Limit Circuit and Thermal Protector

Explosion Proof Version Available

Forward/reverse function

Digital tachometer

Low Noise

E-mail : thailandlab@vnuasiapacific.com bioasiapacific@vnuasiapacific.com futurechem@vnuasiapacific.com

Tel : +66 2 111 6611 Ext. 241, 243

@thailandlab | @bioasiapacific

Website : www.thailandlab.com | www.bioasiapacific.com

Upcycled products from biopowder

The term “upcycle” is a combination of “up” (indicating improvement or enhancement) and “cycle” (indicating a series of events or a process). When combined, upcycle refers to the process of transforming waste materials, unwanted products, or useless items into new materials or products of better quality or a higher environmental value. This practice helps reduce waste going to landfills and promotes sustainability.

We, INNOLAB magazine would like to present the company that uses upcycling to run their business, BioPowder from Malta. BioPowder produces olive pit, almond shell, peach stone, pistachio shell, avocado stone, apricot stone, argan shell and wallnut shell that can be applied to diversified industries, food, cosmetics and much more. Kathrin Schilling, the Founder and Director of BioPowder, came to reveal BioPowder’s expertise with us.

BioPowder’s Expertise

BioPowder is a specialist in upcycling of agricultural by-products. Fruits, such as olives, apricots, peaches, almonds and pistachios, are processed and shelled. Their stones and shells are generally removed and require disposal. BioPowder collects those side streams and transforms them into multifunctional powders and granules. This waste-to-value strategy follows the principles of a circular economy. The result, fully

natural and biodegradable powder ingredients, offer opportunities to formulators of personal care, food and other end products.

The state-of-the-art technology for manufacturing high-quality products

Our technology is called micronisation, i.e. a combination of different milling and sieving techniques. Prior to making our powders, all raw materials (fruit stones and shells) are carefully screened and dried to make sure they are free of impurities.

We can offer powders and particles of nearly any size range. This includes fine powders below 50 microns and coarse particles up to several millimetres. In personal care, proven applications include exfoliants, texturizers, binders and natural pigments / pigment carriers.

The Related International Standard Compliance

In Europe, where we are based, (cosmetic) chemicals are regulated under the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) framework. Our granules and powders are free of any additives and hence consist of 100% fruit stones. This makes them qualify as agricultural by-products, which is why they are exempt from any approval under REACH.

As natural and compostable cosmetic ingredients, our powders are approved under the ECOCERT raw materials standard COSMOS. Their fully plant-based composition, with lignin and cellulose being the main components, also makes them suitable for use in Halal, Kosher, Vegan and other certified end products.

Quality control & efficacy testing

Effective quality management starts at the raw material level. Our sourcing is very holistic in the sense that we closely work with fruit processors, i.e. businesses where fruit stones and shells become available as by-products. Olive oil mills are our special focus, due to the fact that olive stone powders are our bestselling ingredient. During the olive harvesting season from October through January, our team collects the freshly available olive stones from the oil mills, offering them an additional revenue stream for their by-product. Similarly, BioPowder works with women’s cooperatives in Morocco that produce organic argan

oil. Once the argan fruit is ripe and the kernel is removed for pressing, we buy the argan shells directly at the source.

All incoming raw materials are carefully screened to remove dust, impurities and foreign matter. Drying cycles are effective to remove any pulp sticking to peach or apricot stones and to heat-treat the raw material for better preservation.

During micronisation of the clean and dry raw materials into defined particle size ranges, we apply low tolerances to ensure homogeneous

results. All our batches come with a certificate to confirm the applied micron range.

The Policy on Sustainability

Our mission is two-fold:

1. To drive sustainability through our own upcycling activity.

2. To support our customers in making sustainable end products.

Our activity is part of a local fruit and olive processing ecosystem in the Mediterranean region. Side streams are converted into top-grade ingredients and additives, which is a circular, waste-reducing process. BioPowder's upcycling technologies involve mechanical processing and do not require any chemicals, additives or major quantities of drinking water. The company’s carbon footprint is mainly defined by the used electricity and the raw material logistics. This being said, we should highlight the fact that olive and other fruit trees absorb significant amounts of CO2 from the atmosphere. This carbon capture outweighs the low emissions resulting from our manufacturing activity, which makes the case for a carbon-neutral ecosystem.

From a market perspective, there is a strong push towards less synthetic and more biobased and/or upcycled content in personal care products. Fruit stone powders are a therefore an interesting natural alternative to polymer powders (“microplastics”), mineral, metallic or other nondegradable ingredients conventionally used throughout the industry. While being fully compostable, they can help reduce the overall product carbon footprint and make manufacturers stand out as sustainable innovators.

The Next Step into Asia Market

We are definitely keen on exploring opportunities in the Asian market. Especially South-East Asia has experienced a dramatic shift towards natural ingredients, with Thailand and Malaysia being among the largest importers of argan (oil) products. We seek to leverage this trend by partnering with formulators and manufacturers to develop guide formulations and further ease the transition of brands towards fully bio-based product ranges. 

Healthy Plant-based Diet for Health

What should we eat between a giant steak or a vegetable and tofu salad topped with nuts? It’s probably difficult to answer because it depends on individual preference. Current trends in food consumption embrace a plantbased diet which has become the mainstream of integrative health. Its sources come from both plant products and plant-based meats to meet the needs of consumers and people who maintain health to prevent illness. However, some people may wonder about plant-based diet whether it provides long-term health benefit or it increases the chance of vitamin and nutritional deficiencies.

What is plant-based diet?

Plant-based diet1,2 is an eating pattern that has high proportion of plant-based food sources including grains, dried beans, nuts, seeds, vegetables, leafy plants, tubers, fruits, as well as spices and condiments derived from plants. However, the strictness of plant-based diet varies as follows:

1. Vegan Diet

Focus on eating only plant-based products, but do not eat animal products such as meat, milk, and eggs.

2. Vegetarian Diet

Focus on eating plant-based products and eat some animal products. This group consists of many subgroups including:

2.1 Lacto-vegetarian Diet

Focus on eating plant-based products and eat milk and milk products, but do not eat animal products such as meat and eggs.

2.2 Ovo-vegetarian Diet

Focus on eating plant-based products and eat egg products, but do not eat animal products such as meat and milk.

2.3 Lacto-ovo-vegetarian Diet

Focus on eating plant-based products and eat milk, dairy products and eggs, but do not eat animal products such as meat.

3. Flexitarian Diet

Focus on eating mostly plantbased products and can eat animal

products, eggs, and milk according to the situation. This group is more flexible than other groups.

Plant-based diet for health

Eating plant-based products regularly provides many beneficial nutrients to the body including fiber, monounsaturated and polyunsaturated fats, vitamin C, folate, phytochemicals, as well as antioxidants. However, strict vegetarians may lack certain nutrients such as vitamin D, vitamin B12, iron and zinc1,3-4.

However, the appropriate proportion of animal-derived and plant-derived nutrients is controversial in the medical

community. According to the world data organization, on average people in the USA eat 117 grams of protein (total protein) per day which accounts for 64% of animal protein and 46% of plant protein. While on average people in the UK eat 107 grams of protein per day which accounts for 55% of animal protein. It is obvious that Eastern people consume higher amounts of plant protein; Indians eat 66 grams of protein per day accounts for 77% of plant protein, and Thais eat 63 grams of protein per day accounts for 58% of plant protein. The proper amount of animal-derived and plantderived nutrients depends on various factors including culture, food styles, production, food industry, and appropriate nutritional needs of individuals and populations.

Although animal protein such as meat, milk, eggs, cheese and processed meat provides good quality protein that the body can digest and absorb better than plant protein, it is found that eating excessive quantities may have negative effects on health, for example, it increases the risk of having diabetes, coronary artery disease, colorectal cancer5, etc. A recent study shows that high-protein intake (more than 22% of energy from protein) can lead to white blood cell disorders. It causes the activation of mTORC1 and causes abnormal white blood cell function which may lead to cardiovascular disease in the future. Additionally, animal protein contains saturated fat, so the extra high protein

intake may lead to imbalance in energy intake and endothelial dysfunction. Therefore, increasing the proportion of plant protein to replace animal protein would be a good choice to prevent chronic disease and cardiovascular disease in the future.

The research result supports the health benefits of plant-based diets containing soy protein. It analyzes the data of 29 studies from 1,660,304 people at 2.5 - 24 years and found that eating more soy protein can decrease diabetes risk at 17%. It shows that high protein intake, especially animal protein, can increase diabetes risk, while the plant protein intake, especially soy protein, can prevent diabetes. It is also found that consuming soy protein helps reduce the risk of coronary heart disease by 13%6

The longitudinal study was conducted to 131,342 samples of medical personnel and nurses in the United States to examine the associations of animal and plant protein intake and the risk of chronic disease. It was found that the substitution of animal protein with plant protein was associated with lower risk of the death from coronary heart disease by up to 17%. Moreover, the substitution of processed animal protein with plant protein lowers the risk by up to 49%. This should be beneficial to the USA population who consumes a high proportion of animal protein7.

In addition to the benefits of reducing the risk of cardiovascular disease and diabetes, plant-based diets

including vegetables, fruits, nuts and grains are also good for our digestive health and gut microbiome. Consuming high proportion of meats increases the amounts of proteolytic bacteria that secrete extracellular proteases to decompose proteins and produce uremic toxins. When uremic toxins accumulate in the bloodstream, they cause inflammation of the gastrointestinal tract, liver and kidneys. On the contrary, consuming plant-based diet increases the saccharolytic bacteria that produce short-chain fatty acids (SCFAs). SCFAs act as an energy source for intestinal cells, improve intestinal mucosal integrity, decrease uremic toxins, produce alkaline substances, increase insulin sensitivity, inhibit the inflammatory response of the liver, reduce build-up of acidic toxins in the kidneys8-9. Therefore, a plant-based diet is beneficial to intestinal health by reducing inflammation in the digestive system and other organs.

The healthcare data confirms that plant-based diet has many beneficial effects on human health. It helps lower the risk of diabetes and cardiovascular disease as well as improves gut health. However, further studies should be conducted to determine the appropriate proportion of nutrients from plantbased diet and animal-based diet to maintain a strong and healthy body as well as receive complete and adequate nutrition. 

Article info

1. Wang T, Masedunskas A, Willett WC, Fontana L. Vegetarian and vegan diets: benefits and drawbacks. Eur Heart J. 2023 Sep 21;44(36):3423-3439.

2. Storz MA. What makes a plant-based diet? a review of current concepts and proposal for a standardized plant-based dietary intervention checklist. Eur J Clin Nutr. 2022 Jun;76(6):789-800

3. Kruase’s Food & The Nutrition Care Process 14th ed.Food & Nutrition Delivery Craig WJ. Nutrition concerns and health effects of vegetarian diets. Nutr Clin Pract. 2010 Dec;25(6):613-20

4. Neufingerl N, Eilander A. Nutrient Intake and Status in Adults Consuming Plant-Based Diets Compared to Meat-Eaters: A Systematic Review. Nutrients. 2021 Dec 23;14(1):29

5. Mittendorfer B, Klein S, Fontana L. A word of caution against excessive protein intake. Nat Rev Endocrinol. 2020 Jan;16(1):59-66

6. Zuo X, Zhao R, Wu M, Wan Q, Li T. Soy Consumption and the Risk of Type 2 Diabetes and Cardiovascular Diseases: A Systematic Review and Meta-Analysis. Nutrients. 2023 Mar 10;15(6):1358.

7. Song M, Fung TT, Hu FB, Willett WC, Longo VD, Chan AT, Giovannucci EL. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med. 2016 Oct 1;176(10):1453-1463

8. Carrero JJ, González-Ortiz A, Avesani CM, Bakker SJL, Bellizzi V, Chauveau P, Clase CM, Cupisti A, Espinosa-Cuevas A, Molina P, Moreau K, Piccoli GB, Post A, Sezer S, Fouque D. Plant-based diets to manage the risks and complications of chronic kidney disease. Nat Rev Nephrol. 2020 Sep;16(9):525-542

9. Sidhu SRK, Kok CW, Kunasegaran T, Ramadas A. Effect of Plant-Based Diets on Gut Microbiota: A Systematic Review of Interventional Studies. Nutrients. 2023 Mar 21;15(6):1510

Emulation an Ecosystem for a Multi-ome

Skin Protection

Interkingdom symbiosis: A new milestone for beauty development

The intricate complex fabric of an ecosystem, plants, animals, and microorganisms maintain various interkingdom symbiotic relationships that are essential for the balance and vitality of the entire system. Endophytic relationships, where microorganisms reside within the tissues of plants, contribute significantly to the health and resilience of the ecosystem. These microscopic inhabitants play pivotal roles in nutrient cycling, disease resistance, and overall ecosystem stability, showcasing the delicate balance and interdependence that define the natural world.

The big data’s ubiquitous presence in the modern world mirrors the horizontal gene, molecule, and enzyme transfer of these interkingdom relations.

The phenomena represent dynamic information flows that fuel innovation and adaptation. While big data enables insights and informed decisions, ecosystem symbiosis promotes genetic diversity and evolutionary resilience by facilitating the spread of advantageous genetic traits.

TRIPLOBIOME™ [The technology]

With its ‘Do Care’ values, Provital has dedicated many years to finally presenting a game-changing range of active ingredients that will be able to activate skin intelligence via the transfer of nature’s ancient wisdom. Just like in a real ecosystem, the first-of-its-kind Triplobiome platform integrates the power of the Animal and Plant kingdoms, together with their microbiome, to bring unprecedented symbiotic synergies for the development of new cosmetic ingredients.

Interkingdom symbiosis for ecosystem ingredients, with the persistent goal of maintaining the biodiversity – key for ecosystem balance – and preventing the use of the current huge plant biomass that is needed to achieve active compounds for cosmetic purpose, Provital has embarked upon a breakthrough biotech platform that uses plant endophytes as a sustainable and effective source to produce new natural active ingredients.

Why Endophytes?

Endophytes are symbiotic microorganisms that live inside plants promoting beneficial effects on their growth and development. This plant microbiota exhibits a remarkable capacity for synthesizing bioactive phytochemicals, providing a viable alternative for producing cosmetic actives while mitigating the overexploitation of host plants.

The first ecosystem ingredient ever developed through Triplobiome technology

With Triplobiome Technology, Provital is now able to isolate a relevant collection of endophytic strains and to start a screening of bioactivities to select the best candidates for subsequent developments. Shiloxome™ is the very first of these developments that Provital is presenting to the world. It is the 1st real ‘ecosystem ingredient’, a 100% traceable, eco-responsible and biotechnologically obtained cosmetic active that encompasses everything that the Triplobiome concept represents. Shiloxome is the result of the isolation of the endophytic yeast Kwoniella mangroviensis from the inside of the bark of the cork oak (Quercus suber). It is an incomparably shielding ingredient that provides the skin with the capacity to adapt, survive, and protect itself. Just as nature offers the most comprehensive protection to its coexisting inhabitants, Shiloxome creates an ecosystem that goes beyond skin protection.

Shiloxome takes that protective power to create a well-aging active ingredient with anti-pollution and restructuring properties for the skin’s protective barrier. By standardizing it in metabolites such as beta-glucan and xylitol – which have proven moisturizing, anti-irritant, antiwrinkle, wound healing, antioxidant, and barrier function stimulating properties. Hydroxylated C18 fatty acids, as well as other bioactive compounds such as phenyllactic acid, 5-methoxyindoleacetate, and succinic acid possess interesting bioactive properties such as antimicrobial, antioxidant, and collagen degradation inhibition. Some of them (e.g., phenyllactic acid and some indoleacetic acid derivatives) are well-established plant growth promoters (produced

by yeast - endophytes) that stimulate both rapid and long-term responses in plants by regulation of various developmental and physiological processes. Therefore, Shiloxome’s restructuring effect on the skin is the result of transferring a natural endophytic protective system to the skin.

Going beyond barrier care with a multi-ome skin protection

In the ever-evolving landscape of skincare, enhancing the skin’s natural defenses such as the skin barrier has become paramount. In light of emerging trends around the effect of the exposome or microbiome health, the integration of a comprehensive protection in skincare products emerges as a holistic approach, adeptly catering to the evolving needs and preferences of today’s consumers. Besides, in the face of mounting environmental challenges and the omnipresent threat of pollution in daily lives, the demand for effective skincare solutions that provide robust protection has never been more critical. Shiloxome not only addresses the escalating concerns of skin health but also acts as a formidable shield against the pervasive pollutants. Shiloxome stands as an effective shield, safeguarding the skin against the detrimental effects of pollution, while nurturing a harmonious relationship between nature and human health.

In vitro efficacy: Anti-pollution quantification of Shiloxome

Protection from urban dust on Human Epidermal Keratinocytes (NHEK), Shiloxome elicits protective effects on current hyper-polluted lifestyle of most people, the levels of ROS (Radical Oxygen Species) is quantified, and the expression of genes involved in inflammatory

response after the treatment of keratinocytes with urban dust while Urban Dust elicits a strong increase in ROS production, a concentration of 0.186% of Shiloxome significantly prevents ROS formation. Moreover, Shiloxome prevents the increase of 5 well-known inflammation mediators (CCL5, COX2, CSF2, GRO1 and TNFA) from which Urban Dust triggered its increase.

In vivo efficacy: Microbial diversity analysis

In its balanced state, the microbiome acts as a key ally against the exposome in general, hence maintaining the health of our skin, often compromised by pollution, and other harmful substances. The skin microbiota diversity - measured by two different indexes - was not altered during the 56-day study by either placebo or Shiloxome, thus indicating how Shiloxome maintains the skin’s natural microbiome that will prevent potential alterations caused by external factors such as pollution.

Lipidomic Analysis

Cutting-edge lipid barrier care solutions need to emerge as a vital intervention, not only in preserving the skin’s integrity but also in promoting well-aging benefits. By incorporating new lipid-enhancing mechanisms for the stratum corneum, Shiloxome actively works to replenish the lipid barrier, bolster moisture retention, and enhance the skin’s elasticity and suppleness for the well-aging (& menopausal) consumer.

The stratum corneum (SC) matrix is composed of free fatty acids (FAs), cholesterol, and ceramides (CERs), which play a key role in the skin barrier function. Total of 114 lipids were found significantly different after treatment with Shiloxome vs placebo, a bioinformatic analysis was performed with the differentially regulated lipids, to better understand the impact of Shiloxome on the skin lipidome. In this regard, two different breakthrough outcomes were found:

1. Shiloxome prevents the skin lipids from pollution-induced oxidation. Shiloxome clearly outperformed Placebo in reducing lipid oxidation.

2. Shiloxome increases the total chain length of the lipidome. The cutting-edge lipidome analysis strongly suggests that Shiloxome modulates the endogenous lipidome profile towards lipids with longer chains, thus improving the skin barrier’s protective function in polluted environments and contributing to the restructuring of a youthful and healthy skin.

Instrumental Analysis

The results of the various instrumental tests were evaluated at D0, D28 and D56, and proved that Shiloxome significantly promotes:

- Hydrated skin barrier

- Recovery of the glowy appearance

- The skin tone is more even

- Smoother microstructure

- Triple reestablishment of skin elasticity

Overall, the multi-omic efficacy study performed for Shiloxome, proves that it visibly combats aging signs by enhancing the skin’s natural barriers, hence safeguarding the skin against pollution, and making it the perfect solution to aging consumer needs, including post-menopausal skin. 

Mycotoxin Tests for Animal Feed

Food safety is an important issue not only in the food and beverage industry but also the animal feed industry. Cereal producer and livestock producers as well as The Food and Agriculture Organization of the United Nations (FAO) estimate that more than 25% of agricultural products worldwide are contaminated with mycotoxins. The use of pesticides, fungicides, or even the use of chemicals to manage mycotoxins in the raw materials, all of which increase production costs. It has a direct impact on the economy and consumers. causing the price of animal feed products to increase. In addition, consumers themselves may be affected by health effects from eating animal by-products such as meat, eggs, and milk, which are the result of animals eating animal food contaminated with mycotoxins or chemical residues from the production process. Therefore, to reduce contamination and production costs, screening to control the amount of mycotoxins in raw materials is the best choice.

Screening methods for detection of mycotoxins in feed

Usually, screening assays are developed in the form of kits which are extremely relevant tools for monitoring mycotoxin in feed ingredients and feed either by analysts with time constraints for making decisions or by those where other methods may not be available due to cost or situation. These methods for single or whole mycotoxin classes compromise both qualitative tests that show the presence or absence of the target impurity and tests that yield semi-quantitative or quantitative results. Immunoassaybased methods and biosensors are among the screening methods.

Immunoassay-Based Methods

Methods based on immunoassays are settled in the recognition of specific antibodies with mycotoxins that act like antigens. Detection is typically facilitated by the presence of a marker. This compound can be radioactive, chromogenic, or fluorescent and reacts with an enzyme, generally horseradish peroxidase (HRP). Immunoassays without the marker are based on the natural fluorescence of some mycotoxins, or in measures of conductivity. These tests are preferably employed for the first level screening and survey studies on mycotoxin contamination due to their simplicity, cheapness, sensitivity, and selectivity, although crossreactivity with structural analogues can occur. Plus, they do not require sophisticated equipment or skilled personnel. These methods are in continuous development in various formats, aiming to provide rapid, portable and easy to operate systems. Enzyme-linked immunosorbent assay (ELISA), lateral flow immunoassay (LFIA). and fluorescence polarization

immunoassay (FPIA) are included in this category of screening methods.

LFIA

Lateral flow immunoassay (LFIA) or membrane-based test strips are commercially available in the form of kits providing mainly visual qualitative results that indicate the presence or absence of a specific mycotoxin below a predetermined fixed level. More recently, semi-quantitative detection is possible using a portable photometric strip reader. In LFIA, the sample flows along the strip by capillary migration and two lines are formed, the test line whose intensity is inversely correlated to the mycotoxin concentration, and the control line that allows the assay validation. Therefore, as the concentration of toxin in the sample increases, the test line density decreases. These line densities are converted into quantitative results displayed in ppb or ppm. This is an inexpensive screening tool that enables rapid, one-step, and in situ analysis.

ELISA

Enzyme-linked immunosorbent assay (ELISA) methods represent a commonly used immunoassay method to rapidly monitor mycotoxins and are routinely used by agrofood laboratories. For all regulated mycotoxins, there are commercially available ELISA microtiter plate kits that have well-defined applicability, analytical range, and validation criteria. There are several ELISA formats commonly accessible, however, in this field of analysis the predominant form is the competitive one. This is a strategy normally used when the antigen is small and has only one antibody binding site (epitope), which is the case of mycotoxins. A direct

competitive ELISA in a microwell format, which allows the user to obtain exact concentrations in parts per billion (ppb). Free mycotoxin in the samples and controls is allowed to compete with enzyme-labeled mycotoxin (conjugate) for the antibody binding sites. After a wash step, substrate is added, which reacts with the bound conjugate to produce color. More color density means less mycotoxin. The test is read in a microwell reader to yield optical densities. The optical densities of the controls form the standard curve, and the sample optical densities are plotted against the curve to calculate the exact concentration of mycotoxin.

FPIA

Fluorescence polarization immunoassay (FPIA) indirectly measures the rate of rotation of a fluorophore (tracer) in solution based on the competition between the free mycotoxin on the sample and the mycotoxin labelled with the tracer towards a specific antibody. When tracers bind to the antibodies their rotation is restricted, and consequently, the fluorescence polarization value increases. Therefore, if a sample has a high concentration in the target mycotoxin it competes with the tracer for the interaction with the antibody resulting in free tracers with a faster motion, in other words, a low fluorescence polarization signal. Basically, this value is inversely proportional to the amount of free mycotoxin in the sample. The FPIA is reliable, rapid, easy to perform, and relatively suitable for automation, however, their solution-based nature makes it less easy to use in field scenarios.

Mycotoxin kit selection tips

Technology improvements have allowed testing to be taken out of the traditional laboratory setting and placed in the hands of all operators having minimal laboratory experience. When choosing a test kit, make sure it meets the demands of the facility. Facilities need to do a risk assessment to determine which grains and feeds need mycotoxin testing. Features such as workflow, extraction solvent, range of results needed, and kit storage can vary kit to kit.

Accuracy - Inaccurate results defeat the purpose of testing.

Speed - Large facilities need to process many samples.

Simple test instructions - Having easy to follow instructions is critical to ensure new users are performing the test correctly and obtaining high quality results.

Data management capabilities - Mycotoxin kit suppliers should help their customers access their test data in real-time. This helps them make better risk management and merchandising decisions.

User friendliness - Mycotoxin tests should be user-friendly for any employee to perform the test, reducing potential errors from the measurement.

Reveal Q+ and Reveal Q+ MAX Tests

• Quantitative - Knowing the accurate level of toxins present allows you to evaluate the safety of your raw materials and compliance with regulatory levels.

• Easy Data Management - Protect the integrity of your data with the automated transfer of data from the system to your data program.

• Provides Fast, Actionable Results - The lateral flow format simplifies your work process and standardizes

your testing protocols.

• Easy To Use - Minimal training and equipment required.

Reveal Q+ lateral flow format utilizes solvent and water based extractions needed for analysis of complex commodities. The tests available include aflatoxin, DON, fumonisin, ochratoxin, zearalenone, and T2/HT2. The Reveal Q+ Endpoint format is designed for use when increased workflow output is needed.

Reveal Q+ MAX Aqueous Extraction Tests are Available for Aflatoxin, DON, Ochratoxin, T-2/ HT-2 and Zeralenone.

Results from the lateral flow format tests are interpreted using the innovative Raptor® platform.

Veratox®

Veratox® quantitative ELISA microwell assays are perfect for those with laboratory set ups from food manufacturers to commercial and government laboratories. These tests provide accurate quantitative results in a wide range of levels including lower levels with our high sensitivity assays.

• Quantitative — Get an exact concentration of any toxins present within your samples to determine the safety and regulatory compliance of your products.

• Batch Testing — Our ELISAs allow you to test up to 19 samples at a time against test controls.

• Precise Results — ELISA testing produces comparable results to analytical methods, such as HPLC.

• Efficient Workflow — With only minimal training required, the simple process means no wasted time or resource within your lab.

Our Veratox ELISA test kits are available for aflatoxin, DON, ochratoxin, zearalenone, T-2/HT-2

toxin, and fumonisin. ELISA assays can be read using the Awareness Statfax Reader or other microwell plate readers.

For analysis at lower levels of contamination, we offer our high sensitivity (HS) option for aflatoxin, DON, fumonisin and ochratoxin. In addition, we have kits that utilize an aqueous extraction that includes Veratox MAX for Total Aflatoxin, Veratox MAX for Total Aflatoxin HS, and Veratox MAX for Zearalenone. Veratox MAX for Total Aflatoxin, Total Aflatoxin HS, and Zearalenone are the first microwell tests available utilizing an aqueous extraction.

Aflatoxin M1

For dairy products such as milk, milk powder, butter, or cheese, we also offer a rapid ELISA test for the detection of aflatoxin M1 at 5–100 ppt in just 45 minutes, and lateral flow options for rapid screening in five minutes.

Screening vs. Quantifying Results

Our rapid tests for the detection of mycotoxins are available in multiple formats. Reveal® and Reveal MAX tests are the easiest available for those who require only a simple yes/no result, providing screening results in as little as two minutes. Veratox, Reveal Q+ and Reveal Q+ MAX provide results in exact parts per million or billion, in just minutes. Each requires only a minimal amount of training and equipment. 

The Thai Feed Standards

อาหารสัตว์ในที่นี้จะหมายถึงอาหารสัตว์ที่ผลิตเพื่อเลี้ยงสัตว์อาหารตั้งแต่ระดับครัวเรือนจนถึงระดับอุตสาหกรรม

The animal feed mentioned in this article refers to feeds produced for food animals, from the household level to the industrial level, and includes pet food. Animal feed is an extremely crucial factor for farmers because it accounts for the farming cost, which can be as high as 70% or more. Selecting quality and safe animal food in compliance with standard criteria determines the profitability of animal farming.

Animal feed production is an industry that has been growing, especially for large manufacturers. Because animal feed depends on economies of scale, starting at sourcing or producing raw materials, negotiating, transporting, or even market dumping.

Considering the agricultural definition, animal feed can be broadly categorized into two types:

1. Roughage; animal feed with more than 18% dietary fiber and less than 50% of all digestible nutrients, including plants such as grasses and legumes, for example. It can be further divided into three subtypes: fresh roughage, dry roughage, and fermented roughage.

2. Concentrates mean animal feed with less than 18% dietary fiber and highly digestible nutrients.

- Main nutrition, basic nutrition, or energy foods such as broken rice, bran, etc.

- Protein supplements are foods that have at least 20% protein and are mixed with basic foods to increase protein. Proteins could be plant, animal, or synthetic proteins.

- Mineral and vitamin supplements refer to foods that are high in vitamins, whether natural or synthetic.

The Thai Animal Feed Laws and Standards

Animal feed standards in Thailand have the highest hierarchy, according to the Animal Feed Control Act, B.E. 2558. This law specifies the authorities and duties of officials, the establishment of relevant committees, applying for and issuing licenses, registration, and the authority and responsibility for

issuing relevant licenses. The Act sets out the general definition of animal feed and specifically controlled animal feed. The latter refers to animal feed that has economic and social impacts, may be harmful to animals, or affects meat consumers. Production for sale or import for sale of specifically controlled animal feed must be registered.

The Act allows no person to produce, import, or sell the following animal feed: animal feed that is contaminated, animal feed that has deteriorated in quality, animal feed that does not meet required standards, animal feed that shall be registered but has not been registered, and establishes some important definitions:

Contaminated animal feed shall mean animal feed that is made from other ingredients that are not specified in the registration, except ingredients that may occur naturally.

Animal feed that has deteriorated in quality means animal feed that is past the expiration date displayed on the label, has other ingredients that may become poisonous, or is otherwise harmful to animals pursuant to the characteristics, categories, and quantity prescribed.

What are the specifically controlled animal feeds?

According to the Announcement of the Ministry of Agriculture and Cooperatives regarding the specification of specifically controlled animal feed, B.E. 2558, Announcement (No. 2) B.E. 2559, Announcement (No. 3) B.E. 25590, and Announcement (No. 4) B.E. 2560 specify several

specifically controlled animal feeds, which can be divided in summary as follows:

Raw materials such as soybean meal, peanut meal, oil extracted bran, corn meal, fish and fish bone meal, fat-extracted meat meal, and meat and bone meal.

Dairy products for animals, such as powdered milk and whey powder for feed, whey powder.

The Announcements specify that feeds used for chickens, ducks, quails, pigs, cattle, buffalo, dogs, cats, rabbits, frogs, soft-shelled turtles, sea shrimp, freshwater shrimp, catfish, herbivorous freshwater fish, carnivorous freshwater fish, and sea fish are specifically controlled animal feeds.

1. Premixed feeds include animal feed concentrates, ready-made mixed feed, and premixes.

2. Dietary supplements for animals include protein, mineral, or fat supplements.

The Announcement determines that dog and cat feeds are specifically controlled animal feeds.

1. Complete pet food

2. Complementary pet food

3. Therapeutic pet food

Quality and standards of specifically controlled animal feeds are compiled in the Announcement of the Ministry of Agriculture and Cooperatives: Quality or Standards of specifically controlled animal feeds, such as the Announcement B.E. 2558. It specifies the quality or chemical standards of specifically controlled animal feeds according to the ratio calculated as a

percentage of raw material weight: protein not less than 55%, fat not more than 15%, pulp not more than 4%, moisture not more than 10%, and ash not more than 25%, for example.

Principle of Good Manufacturing Practice (GMP) for Feed Manufacturing

Principles of Good Manufacturing Practice (GMP) for feed manufacturing are principles and practices that implement the same principles as human food production. GMP was initiated and developed by Codex Alimentarius, or CODEX GMP, to enable manufacturers to comply and produce safe food. It emphasizes preventing and eliminating hazards that may harm consumers. GMP is a basic quality assurance system before developing into other quality assurance systems. It covers the following elements:

1. Sites and production facilities

2. Machines, tools, and production equipment

3. Production process control

4. Management system after defected product detection

5. Sanitation

6. Maintenance and cleaning

7. Personnel and personal hygiene

Hazard Analysis and Critical Control Point (HACCP) focuses on controlling the production process, especially determined critical control points (CCP). Therefore, before applying the HACCP system, the production facilities shall be prompt with GMP as well as regulations related to food safety.

Good Hygiene Practices (GHP) and HACCP

In 2020, Codex Alimentarius announced GHPs & HACCP rev.52020 or “General principles of food

hygiene: Good Hygiene Practices (GHPs) and Hazard Analysis and Critical Control Point (HACCP)” GHPs and HACCP are two preventative controls that can be used to ensure food safety. GHPs are the basis of all food hygiene systems, while HACCP focuses on control measures for significant hazards. Both GHPs and HACCP are part of the food chain industry standard that helps ensure products meet food safety and legal requirements.

GHPs include personnel hygiene and training, cleaning and sanitation, maintenance and services, pest control, plant and equipment, premises and structure, storage, distribution, and transport, and waste management.

The Thai Animal

Feed to the Global Market

In 2024, the Thai Government has announced that Thailand will become a world leader in the production and export of animal feed. It accelerates confidence in quality and safety to support the needs of the global market. It is expected that animal feed exports will reach 300 billion baht this year. The Ministry of Higher Education, Science, Research and Innovation (MHESI) is following the guidelines of the Prime Minister. It controls the Thai animal feed products to meet quality standards and safety, as well as economic animal feed and pet food. It promotes a complete food industry chain that covers every production process from upstream to downstream.

Department of Science Service (DSS) develops the potential of industrial groups related to animal feed production. It focuses on manufacturing process quality assurance in analytical laboratories, quality control, laboratory development,

and building a network throughout the country, as well as applying for certification as a reference material producer for animal feed under international standards.

We can see that opportunities to expand animal feed production. But the government shall answer whether entering the highly competitive animal feed with intense price competition is worth and reasonable. In addition, in the past, animal feed production has exploited heavy environmental costs, such as monoculture cultivation, biomass burning, and destructive fishing. Expectation of only economic value creation is not enough. Opportunity costs, environmental costs, and socio-economic costs shall be considered. 

ตัวอย่างในข้าวและผลิตภัณฑ์จากข้าว เช่น

ผลิตภัณฑ์ สารปนเปื้อน ปริมาณ

เมล็ดธัญพืช แคดเมียม 0.1 มก./กก.

ข้าวขัดสี แคดเมียม 0.4 มก./กก.

ข้าวขัดสี สารหนูอนินทรีย์ 0.2 มก./กก.

ข้าวกล้อง สารหนูอนินทรีย์ 0.35 มก./กก.

ข้อสังเกตคือมาตรฐานฉบับนี้ได้ระบุ

มาตรฐานการปนเปื้อนของสารพิษเชื้อ

ราในธัญพืช ได้แก่ ดีออกซีนิวาลีนอล (Deoxynivalenol: DON) ฟูโมนิซินบี

1 และบี 2 (Fumonisins B1+B2) โอครา

ทอกซินเอ (Ochratoxin A) พาทูลิน (Patulin) แต่ไม่มีอะฟลาทอกซิน

2. สารพิษตกค้าง เป็นไปตาม มกษ. 9002 มาตรฐานสินค้าเกษตร เรื่อง สาร พิษตกค้าง: ปริมาณสารพิษตกค้างสูงสุด

ซึ่งครอบคลุมวัตถุอันตรายทางการเกษตร (pesticide) áละ มกษ. 9003 มาตรฐาน สินค้าเกษตร เรื่อง สารพิษตกค้าง: ปริมาณ สารพิษตกค้างสูงสุดที่ปนเปื้อนจากสาเหตุที่ ไม่อาจหลีกเลี่ยงได้ ครอบคลุมวัตถุอันตราย

ทางการเกษตรที่ไม่อนุญาตให้ใช้แล้ว การวิเคราะห์อาหารเพื่อความปลอดภัย

มาตรฐานสินค้าเกษตรและอาหารแห่งชาติ

มกอช. 9007-2548 ข้อกำาหนดด้านความ

ปลอดภัยสินค้าเกษตรและอาหาร กำาหนด ให้ใช้วิธีวิเคราะห์สารพิษตกค้าง ยาสัตว์

ตกค้าง สารปนเปื้อน วัตถุเจือปนอาหาร

และจุลินทรีย์ตามข้อที่กำาหนดโดย Codex

กรณีที่วิธีวิเคราะห์ไม่ครอบคลุมรายการที่ ต้องการวิเคราะห์ ให้เลือกวิธีอื่นที่พิจารณา

ว่าเป็นวิธีวิเคราะห์ที่มีคุณสมบัติการใช้งาน (performance characteristics) เหมาะ สมกับรายการวิเคราะห์นั้น และเป็นไปตาม

หลักเกณฑ์ข้อใดข้อหนึ่ง ดังต่อไปนี้

1. เป็นวิธีวิเคราะห์ที่ประกาศโดยองค์กร

แห่งชาติ หรือองค์กรระหว่างประเทศด้าน

มาตรฐาน หรือตีพิมพ์ในเอกสารคู่มือหรือ สิ่งตีพิมพ์ที่เป็นที่ยอมรับระดับสากล

2. เป็นวิธีวิเคราะห์ที่มีผลการประเมิน ความใช้ได้ (validation) ของผลการทดสอบ

ว่ามีความถูกต้องและเหมาะสม โดยห้อง ปฏิบัติการที่มีการร่วมศึกษากับเครือข่าย (collaborative study) ตามหลักเกณฑ์

National Bureau of Agricultural Standards, The Ministry of Agriculture and Cooperatives, has set standards for “Thai rice” in 2017 (Thai Agricultural Standard TAS 4004-2017 Thai Rice) by improving standards for controlling production and trade conditions. It was developed based on previous versions; including Thai Fragrant Rice Product Standards B.E. 2559, Rice Product Standards B.E. 2559, Thai Fragrant Jasmine Rice Standards TAS 4000-2006, Thai Fragrant Rice Standards TAS 4001-2008, Rice Standard TAS 4004-2012, ISO 24333:2009 Cereals and allowance product sampling, and CODEX STAN 198 - 1995 Rice. The standard is applied to Thai rice (Oryza sativa L.) produced in Thailand. This standard applies to paddy rice, brown rice, and packaged white rice, excluding fragrant rice varieties covered by separate standards (TAS 4000 and TAS 4001).

According to the standard, rice is categorized as paddy rice, brown rice, white rice, and glutinous rice. The criteria are also categorized, based on amylose content, into 4 groups.

Criteria for Thai rice

1. Physical Characteristics: Appearance, moisture content, foreign materials, broken rice, damaged kernels, and quality grading criteria.

2. Packaging.

3. Labeling and marking are divided; products sold directly to consumers, and products not sold directly or unpackaged bulk quantity product.

4. Contaminants and Pesticide Residues: Compliance with regulations and relevant agricultural standards.

5. Hygiene in the processing, packaging, transportation, milling and packaging practices. Practices in paddy fields that shall be certified with Good Agricultural Practices (GAP) or an equivalent standard.

6. Analysis and sampling, in the annex of the standard, sampling methods are specified in detail, including chemical and physical methods mainly for quality testing.

Risks in cereals and grains

There are risks in the production of cereal foods, including:

1. Hazards from mycotoxins include aflatoxins found in peanuts and brown rice products, fumonisins in corn snacks, ochratoxins in nuts and brown rice products, Red Cargo rice, wheat, oats, sorghum, barley, millet, and lotus seeds, zearalenone in corn and products.

2. Hazards from pesticides including Aldrin, Dieldrin, Endrin, DDT, Alpha-BHC, Heptachlor & heptachlorepoxide and Lindane.

3. Physical hazards from foreign objects such as insects, fur or hair, and animal feces.

4. Biological hazards from gastrointestinal pathogenic bacteria such as Bacillus cereus, Staphylococcus aureus, E. coli.

Safety standards

1. Contaminants - Announcement of the Ministry of Public Health (No. 414) B.E. 2020 regarding standards of food containing contaminants. Examples in rice and rice products include:

mg/kg.

It is noted that this standard specifies for mycotoxin contamination in cereals, including deoxynivalenol (DON), fumonisins B1+B2, ochratoxin A, patulin, but not for aflatoxins.

2. Pesticide residues are in accordance with TAS 9002Agricultural Standards on Pesticide Residues: Maximum Residue Limits - covers agricultural hazardous substances (pesticides); and TAS 9003 - Agricultural Product Standards on Pesticide Residues: Extraneous Maximum Residue Limits - covers agricultural hazardous substances that are no longer permitted for use.

Food safety analysis

Thai Agricultural Commodity and Food Standard TACFS 90072005 - Safety Requirements for Agricultural Commodity and Food –requires residue analysis methods for pesticides, veterinary drug residues, contaminants, food additives, and microorganisms as specified by the Codex Alimentarius. When there is no analytical method cover the item to be analyzed, select another method with appropriate performance characteristics to that analyzed item and complied to one of the following criteria:

1. The analysis method announced by a national organization or an international organization for standards or published in manuals or publications that are internationally recognized.

2. The analysis method with appropriated results of method validation by laboratories joined with the collaborative study, the criteria are complied with of generally accepted international organizations.

3. There is no analytical method according to 1 or 2, implement the analysis method which is validated by the laboratory. The criteria are based on the single laboratory validation criteria that is internationally recognized.

How is the old-stocked rice, is it edible?

The headline news gaining attention today is the release of rice that has been stored for 10 years. Prof. Dr. Apichat Wannawijit, an academic at the Rice Science Center, Kasetsart University Kamphaeng Saen Campus published an article giving comments on the Rice Research Center’s fan page as follows:

1. Rice should be stored in a cool, dry place, away from light and moisture. It should be stored in an environment that is vacuum or close to extend shelf life and maintain quality.

2. Before consuming long-stored rice, check for signs of deterioration, such as unusual odors, discoloration, or the presence of insects or mold. Any of these signs indicate that the rice should not be consumed.

3. Nutritional value of longstored rice may decrease, such as loss of thiamine (vitamin B1), for example.

4. Changes in cooking quality and taste, cooking quality of rice may change over time. Crystalline structure of longstored rice may alter,

water absorbability may change. It affects gelatinization temperature and starch retrogradation. In addition, color, aroma, texture, or taste of cooked rice may also alter.

5. Chemical residue from storage. Rice storage in the warehouse needs fumigation with chemicals to prevent flour beetles, insects, or mold. The process is conducted multiple times due to long storage. There may be a risk of chemical residue.

6. Mycotoxins. There is also a risk from certain mycotoxins such as aflatoxin and ochratoxin A which shall be verified.

What is rice fumigant?

Fumigation reagents to protect against insects are methyl bromide and phosphine groups.

Methyl bromide is a colorless, odorless, and non-flammable gas. It kills insects at all stages of growth. It

disperses and penetrates into products well. Fumigation time is short, and it decompose within 3 hours to 5 days with no toxic residue.

Phosphine is a gas of a phosphide compound, namely aluminum phosphide. It is flammable and odorless. Fumigants in granular form can be used in product packed in sacks or bags, or storage facilities. It spreads quickly, taking about 5-7 days to fumigate while taking about 5 hours to decompose.

The 3rd International Healthcare Week (IHW), driven by the Hong Kong Trade Development Council (HKTDC), will run from May 15-31, 2024 in Hong Kong, helping to promote innovation, investment and exchange by fully utilising Hong Kong’s strategic role as an innovation and investment hub for Asia’s healthcare industry.

The two flagship events of IHW are the 4th Asia Summit on Global Health (ASGH) co-organised by the Government of the Hong Kong Special Administrative Region (HKSAR) and the HKTDC, and the 15th Hong Kong International Medical and Healthcare Fair (Medical Fair) organised by the HKTDC.

The two concurrent events encompass both upstream and downstream healthcare industries, from technology research and development, investment matching and medical device manufacturing, to medical products and services. Together they form a comprehensive one-stop platform to create synergies for medical and healthcare industry professionals.

Asia Summit on Global Health

Since its launch in 2021, ASGH has developed into a signature event for the healthcare industry in the region. The last edition of the Summit brought together more than 90 internationally renowned speakers and 2,500 participants from 40 countries and regions. More than 300 one-on-one Deal-making meetings were arranged during the Summit.

Themed “Innovation Inclusion Impact”, the Summit in 2024 will bring together policy makers, healthcare experts, business leaders, start-ups and investors from around the world to exchange insights and explore opportunities for collaboration. It will comprise a high-level symposium covering a wide range of topics on global health, healthcare innovations and investment opportunities in

healthcare in Asia. A series of thematic sessions focusing on the latest trends in different medical sectors, project pitching and deal-making meetings will also be organised to facilitate business discussions and investment partnerships. InnoHealth Showcase, a dedicated exhibition area featuring global healthcare projects and technologies will be staged alongside the Summit.

Hong Kong International Medical and Healthcare Fair

The HKTDC Hong Kong International Medical and Healthcare Fair brings together healthcare professionals, industry leaders, and innovators from around the world. It serves as a platform for showcasing the latest advancements in medical technology, products, and services.

The 2023 edition featured more than 300 exhibitors from Hong Kong and international markets including Canada, Mainland China, Japan, Taiwan, and the United States, and recorded over 10,000 visits from 56 countries and regions. Additionally, more than 600 business-matching meetings were arranged to facilitate exhibitors and buyers in harnessing business prospects.

Highlighted zones in the 2024 fair include Biotechnology, Hospital Equipment, Rehabilitation and Elderly Care, World of Health and Wellness, and more. International buyers will have the opportunity to explore the latest medical technologies, equipment, healthcare and beauty products, and healthcare solutions, while also networking and obtaining valuable insights into the latest trends in the

medical field through knowledgerich events.

Several InnoHealth Showcase exhibitors in ASGH 2024 YnnoMed

Pioneering the development of bacterial transcription inhibitors as new antimicrobial agents, YnnoMed’s invention is a series of small chemical molecules proven effective to kill bacterial pathogens with new modes-of-action, and they are of high potential to become firstin-class antimicrobial medicines made in Hong Kong.

Comfortable and permeable electronic skins

Provide permeable electronic skins for long-term and comfortable health monitoring and disease treatment, offering comfortable sensations during and thus prolonging the wearing or treatment time.

Syngular Technology Limited

Syngular offers AI powered AR medical image solution to make surgery safer and faster.

ViewMind Inc

Through analysis of distinctive eye movement patterns, powered by AI, ViewMind provides unparalleled precision in evaluating cognitive functions. This approach allows for early detection of brain diseases, monitoring of disease progression, and precise measurement of medication impact on cognition.

EMVision

EMVision offers breakthrough

point-of-care neuroimaging solutions for rapid stroke and traumatic brain injury diagnosis

PhoMedics Limited ºCHAMP Microscope™

offers high-resolution images of

and fitness training for the elderly and stroke patients.

Hong Kong Centre for Cerebrocardiovascular Health Engineering (COCHE)

Relying on such lightweight and

Fleming Medlab Limited Fleming MedLab aims to make a significant impact on the lives of stroke patients and their families, providing hope and a path to a better quality of life.

SHAPING THE FUTURE FOR SUSTAINABLE SUCCESS

AT PROPAK ASIA 2024

The saying "to stand still is to be left behind" holds more truth than ever in today's dynamic business landscape. Staying at the forefront of competition requires continuous development, particularly in processing and packaging. ProPak Asia 2024 is gaining increased significance as a vital support ecosystem, striving to empower businesses to tackle challenges with cutting-edge, sustainable, and cost-effective solutions.

The 31st ProPak Asia in 2024, Asia’s leading trade event for processing and packaging technology, enters a new decade with a commitment to being a unique platform for a dynamic and diverse community across the food and beverage, agriculture, personal care, cosmetics, pharmaceuticals, manufacturing, and FMCG industries. It serves as a gathering point for industry c-suite executives, business owners, innovators, and professionals, facilitating a comprehensive spectrum of interactions—from material and machine technology sourcing to product and financial consultancy. Attendees can gain valuable insights into emerging market trends and forge valuable new partnerships.

ProPak Asia 2024 transforms into a central resource hub for ideation, encouraging businesses to explore innovative concepts and sustainable approaches. The event incorporates various components that inspire industry players to stay informed, covering aspects from production to marketing, fostering a culture of knowledge sharing. Innovation takes center stage at ProPak Asia 2024, highlighting state-of-the-art solutions

and breakthrough technologies from top global companies.

The event’s eight industry-focused zones encompass a wide range, spanning from processing and packaging to logistics and warehousing. These zones, including ProcessingTechAsia, PackagingTechAsia, DrinkTechAsia, PharmaTechAsia, Lab&TestAsia, PackagingSolutionAsia, Coding, Marking&LabellingAsia, and Coldchain,Logistics, Warehousing&FactoryAsia, collectively provide a comprehensive platform for professionals to share insights and explore trends.

ProPak Asia 2024 underscores that investment goes beyond financial aspects, incorporating sustainability and adaptability to uncertainty. This call to invest is not exclusive to big enterprises, SMEs and MSMEs are also encouraged to invest with solutions tailored to their scale. The event serves as a springboard for businesses to unlock their potential and capitalize on opportunities.

In pursuit of “Sustainably Empowering Processing and Packaging Success with Ideation, Innovation, Investment” ProPak Asia 2024

offers a holistic approach to industry success, highlighting sustainability, creativity, and strategic investment. By embracing these core principles, industry players aim not only to meet present demands but also to shape a more sustainable and prosperous future. The event, featuring conferences, networking opportunities, knowledge sharing, and informative content, equips businesses with the tools to navigate dynamic global and regional markets effectively, empowering them to achieve their goals.

Continuing the momentum from the successful previous year, which drew a significant number of attendees and exhibitors worldwide to explore various highlighted features, conferences, and 8 industry-focused zones, ProPak Asia 2024 is set to take place from June, 12-15 at BITEC, Bangkok. The event is dedicated to keeping businesses at the forefront of the manufacturing industry by promoting ideation, innovation, investment and ultimately achieving sustainable success.

For pre-registering to attend ProPak Asia 2024, please visit www. propakasia.com. 

Medical Taiwan, the premier international expo for medical, health, and care industries organized by TAITRA, is scheduled to be held at Taipei Nangang Exhibition Center Hall 2 (TaiNex2) from June 20th to 22nd, 2024. In the previous year, amidst the waning pandemic, the event successfully attracted nearly one thousand international buyers from 53 countries. Notably, a quarter of these attendees were high-ranking decision-makers or procurement personnel. Medical Taiwan serves as an invaluable platform for industry players to connect, fostering networking opportunities and expanding business horizons. Building upon its past achievements, the 2024 edition will focus on three themes—Supply Chain Gallery, Smart Medical, and All-age Healthcare—to facilitate businesses in seizing international opportunities across various sectors.

Smart Medical Pavilion Showcases Cutting-Edge Medical Devices Made in Taiwan

Medical Taiwan is backed and attended by key associations within Taiwan’s medical device industry, such as the Taiwan Medical and Biotech Industry Association, Taiwan Federation of Medical Devices Commercial Associations, and Taiwan Bio-medical Care Association, all collaborating to create a comprehensive procurement platform for the medical device supply chain in Taiwan. Of these associations, the Taiwan Medical and Biotech Industry Association is planning to unveil the Smart Medical Pavilion this year. This pavilion will showcase high-end, cutting-edge medical devices made in Taiwan that have received both domestic and international permits for medical device launches and have entered mass production. Notable products on display will include the Kinguide Robotic-Assisted Surgical System by Point Robotics, CUSMED connectCMF Flap Fixator by Ossaware Biotech, EPROB Navigation System by EPED Inc., and Optima Prone, a specialized pressure-reducing support surface solution designed by Wellell, alongside various other surgical equipment and high-end implantable medical devices, which underscores the strength and expertise of Taiwanese industry players in manufacturing high-end and smart medical devices.

Medical Taiwan Showcases Smart Solutions for Digital Health and All-Age Care

With technology constantly evolving and mobile devices becoming increasingly prevalent, the digital health industry has experienced rapid growth. Research Nester projects that the global digital health market will reach an impressive US$980 billion by the end of 2035, exhibiting a compound growth rate of 15% from 2023 to 2035. In the previous year, Medical Taiwan introduced the Future Pavilion, a space designed to distinguish between hospital and home environments, showcasing smart solutions for both. This feature garnered positive feedback from visitors. In this year’s exhibition, there will be a continued focus on digital health issues, highlighting the latest products and applications of smart medical care and all-age care driven by new technologies. For instance, dBio will present AIoT Wearable Stethoscopes and AIoT Smart Insole Sensors, while Hpb will showcase smart care solutions tailored for the elderly and infants.

M-novator, Supported by H-spectrum+, Empowers Biomedical Startups Globally

M-novator, the dedicated space for startup exhibitors at Medical Taiwan, received a positive response in 2023 and is set to broaden its

international reach this year. Teaming up with H-spectrum+, a health tech accelerator associated with Foxconn Tech, M-novator will offer biomedical startups opportunities to launch their products, gain access to demonstration sites, and foster partnerships. Participating startups will engage in personalized interactions with a team of industry experts and consultants, receiving guidance on business model development and effective fundraising strategies. Currently, startups from both domestic and international spheres, such as EYRIS, a Singaporean company specializing in AI-assisted diagnosis systems for retinopathy, and NEODOCS, an Indian startup offering AI diagnosis and health monitoring solutions, have already joined the exhibition.

Matchmaking

Meetings and Networking Opportunities Expanded to Attract Buyers from the AsiaPacific and Emerging Markets

At this year’s exhibition, oneon-one matchmaking sessions will be set up for two consecutive days,

bringing together international buyers and industry players. We have specifically reached out to buyers from the Asia-Pacific region and emerging markets. Anticipating over 100 matchmaking sessions, we are also organizing a buyer networking dinner on the first day of the expo. Our aim is to attract both domestic and international buyers with substantial resources, facilitating connections between Taiwan’s industry players and international markets.

Over 50 Forums, Lectures, and New Product Launches Unveil Trends and Facilitate Knowledge Exchange

Additionally, the exhibition will host over 50 forums, lectures, and new product launches, featuring

seminars focused on the Asia-Pacific medical market. Esteemed speakers from Japan, South Korea, Singapore, Malaysia, Thailand, and Vietnam will be invited to share invaluable insights into local market dynamics and the healthcare industry. Their presentations aim to provide Taiwanese industry players with a deeper understanding of regional healthcare systems, market demands, and regulatory changes. Furthermore, a smart medical product launch conference will showcase the latest advancements in smart medical software and hardware, wearable devices, and IoT home care products. Brand owners will unveil these innovations to the public, enabling industry players to stay ahead of emerging trends and fostering the exchange of new

knowledge within the field.

Medical Taiwan aims to establish a dynamic business and trading platform, providing industry players with the means to enhance their global presence and explore opportunities for crossborder and cross-sector exchanges. We strongly encourage industry professionals to take advantage of this opportunity by registering for the expo. The early bird discount is available until February 28. For registration or more information, please contact Ms. Lin at extension 2221 or Ms. Li at extension 2863 through the registration hotline (02) 2725-5200. You can also visit the exhibition website: www.medicaltaiwan.com.tw for additional details. 

South East Asian International Healthcare Week

With over 400 world-class exhibitors, from more than 50 countries, CPHI South East Asia connects healthcare industry leaders, buyers and decision makers from ASEAN and beyond, to do business. International Healthcare Week coinciding with CPHI South East Asia recognises the event’s strategic role as an innovation and technology hub for the ASEAN healthcare sector.

Better together – three shows in one

“By offering three co-located events: CPHI South East Asia (pharmaceuticals), Medlab Asia (medical lab) and Asia Health (hospital related/medical devices), we aim to provide a comprehensive, one-stop event at the forefront of the ASEAN healthcare market. Having these three premier events in one venue adds real value, as many exhibitors and visitors businesses cover more than just pharmaceuticals,” said Rungphech (Rose) Chitanuwat, Regional Portfolio Director - ASEAN, Informa Markets.

“No matter where you are in the healthcare supply chain, it really is the place to make connections, as well as find inspiration, education, including CME/CMTE accredited conferences, solutions, and much more,” she noted.

South East Asia – an attractive pharmerging market

According to Statista, South East Asia as a region is often referred to as a ‘pharmerging’ market – an umbrella term that encompasses markets characterised by a yet unsaturated need for pharmaceutical products, fast growth, and strong government initiatives and investments in the industry. In recent years, factors such as pricing pressure, patent protection, and regulatory frameworks have slowed down growth in established pharma markets such as the US and Japan. Thus, major pharma companies are increasingly looking to pharmerging markets for their untapped potential. Pharma market growth in the region can be primarily attributed to government efforts towards universal healthcare and synchronised regulatory standards across the region. For example, the ASEAN Pharmaceutical Regulatory Policy (APRP), which includes the sharing of information, and regulatory cooperation, integrates the ASEAN pharmaceutical sector. APRP market harmonisation will facilitate the development of a sustainable and robust regulatory framework for pharmaceuticals within the ASEAN region. This can be expected to further attract

international players to the South East Asian pharmaceutical market while also facilitating approval processes and intra-regional trade for local companies.

APRP will contribute to the ongoing growth of the pharmaceuticals market in ASEAN, which is predicted to achieve a revenue of USD13.39 billion in 2024, with a robust 6.2% CAGR, to reach USD17.05 billion by 2028.

Furthermore, the growing middleclass population in ASEAN is fuelling the demand for health services, as consumers become more willing to spend on their health and well-being. While a lot of pharma demand in South East Asia is met by foreign companies, the region is becoming increasingly attractive as a contract manufacturing destination.

Save the date and register now “If you want to stay at the forefront of innovations and technology in the ASEAN healthcare industry you can’t afford to miss CPHI South East Asia 2024, and its co-located events –Medlab Asia and Asia Health. You can register to attend, July 10-12, 2024, Queen Sirikit National Convention Centre, Bangkok, at www.cphi.com/ sea,” concluded Chitanuwat. 

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