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o ur 4 1 ST ye ar

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Covering Homewood, East Baltimore, Peabody,

Merrick Barn theater named

Study by Carey Business School

SAIS, APL and other campuses throughout the

for actor, teacher and alumnus

professor offers broad lessons on

Baltimore-Washington area and abroad, since 1971.

John Astin, page 6

the value of trust, page 5

December 12, 2011

The newspaper of The Johns Hopkins University

S C H O L A R S H I P

Institute for retired faculty launched at Krieger School

Volume 41 No. 15

H O M E W O O D

The world, and its data, at their fingertips

By Greg Rienzi

The Gazette

Continued on page 4

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will kirk / homewoodphoto.jhu.edu

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he Krieger School of Arts and Sciences has taken a significant step to retain the expertise, talents and wisdom of its distinguished veteran faculty.

In an effort to underscore the importance of research among retired Members of Krieger School The Academy faculty, President Ronald J. Daniels will have title and Dean Katherine S. Newman recently of academic announced the establishment of professor The Academy at Johns Hopkins, an institute for advanced study through which retired professors in Arts and Sciences can pursue research opportunities, conduct and attend academic seminars, and explore other opportunities for continued scholarship.

“Dedication to unceasing exploration lies at the core of our university, and The Academy embodies that spirit of lifelong learning to the fullest,” Daniels said. “It recognizes our emeriti’s continued intellectual achievements, ensures the inspiration of future scholars and fosters Johns Hopkins’ ongoing pursuit of excellence.”

All current tenured Krieger School faculty will be eligible, upon their retirement, for membership and given the title academy professor, a new rank designated by the Homewood Academic Council.

Academy professors may simultaneously hold the title of emeritus professor.

Appointments to The Academy will be made beginning July 1, 2012, the official launch date for the institute.

The Greenhouse, the first building to be built on the Homewood campus, will be renovated to provide a home for The Academy. It will be ready for occupancy next year.

Newman, the James B. Knapp Dean

Freshman environmental engineering major Michael Gao presents his final project in Steve Hellen’s Introduction to Geographic Information Systems and Geospatial Analysis course. Gao used GIS software to map out restaurants and eateries in the neighborhoods near Homewood campus.

New GIS teaching lab, foundation courses are first steps in initiative

By Greg Rienzi

The Gazette

W

ith the room’s lights turned low, the projector screen in Stan Becker’s Population Health and Development class suddenly bursts alive with a detailed 2-D topographical map of the Earth.

A Homewood undergraduate, remote in hand, zooms in on Southeast Asia like an ani-

mation culled from a National Geographic Channel special. With another click, cartoonlike icons appear on the screen representing the chief exports and cultural landmarks of Thailand and Indonesia. By turn, student groups in Becker’s class present visual tours of each of the region’s nations.

Continued on page 5

R E S E A R C H

Solving unknown causes of inherited diseases $16 million grant launches four-year undertaking to identify genetic causes

By Audrey Huang

Johns Hopkins Medicine

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he McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins, in collaboration with Baylor College of Medicine, has been named one of three

In Brief

Carey Business School’s Balto./Istanbul course; Jhpiego in Indonesia; introducing J-List

12

Mendelian Disorders Genome Centers by the National Human Genome Research Institute and will receive $16 million over the next four years to identify causes of genetic disease. The center will be called the BaylorHopkins Center for Mendelian Genomics.

The other two centers will be at University of Washington and Yale University.

“Although they are individually rare, Mendelian disorders in aggregate account for more than 10 percent of inpatients in pediatric hospitals. Moreover, one-third or more of the patients we see in our genetics clinic who clearly have inherited condi-

C A L E N D AR

Development day for KSAS, WSE grad students and postdocs; poetry readings

tions remain undiagnosed after exhausting all possible and available tests,” said David Valle, the Henry J. Knott Director of the McKusick-Nathans Institute of Genetic Medicine. “Now we have the opportunity to solve many of these unknown diseases by identifying the genes and genetic alterations associated with them.”

Valle will co-direct the new center with his counterpart at Baylor, James Lupski.

An estimated 25 million Americans suffer from inherited diseases, most of which Continued on page 9

10 Job Opportunities 10 Notices 11 Classifieds

2 2011 2 THE THE GAZETTE GAZETTE •• December August 15,12, 2011

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East Balto. Community School to receive funding for library

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he East Baltimore Community School, run by Johns Hopkins in partnership with Morgan State University, was announced last week as one of four recipients of funding from the Harry and Jeanette Weinberg Foundation’s Baltimore Elementary/Middle School Library Project.

The multimillion dollar, multiyear initiative, which involves more than 15 community and government partners, will work with Baltimore City Public Schools to design, build, equip and staff new or renovated libraries in selected schools where existing public funding can be leveraged. The foundation is committed to providing up to $1 million in the first year of the project, with direct and in-kind contributions of the partners bringing the total to $3.78 million.

According to the Weinberg Foundation, each school will feature new equipment, reading materials and furniture, including e-readers, a bank of computers and a “parenting corner,” where parents and guardians can share time with their children.

Carey Business School offers ‘global immersion’ course

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he Johns Hopkins Carey Business School plans an information session today, Dec. 12, on a “global immersion” course the school will offer next spring in Baltimore and Istanbul. The session will take place via conference call from noon to 1 p.m.

Open to Johns Hopkins graduate students interested in learning how business competitiveness is developed on an international scale, the two-credit course will consist of three sessions in Baltimore (April 19 and 26, and May 3) and a one-week residency in Istanbul (May 27 to June 2).

Mark Kennedy, an executive in residence at the school and a former three-term congressman from Minnesota, will serve as instructor.

To join the information session, go to connect.johnshopkins.edu/turkey-globalimmersion. The call number is 410-9554009, and the access code is 246800.

For additional information, contact Emmanuel Opati, senior project associate for Carey’s Global MBA program, at emmanuel .opati@jhu.edu.

Jhpiego to lead $55 million fiveyear project in Indonesia

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hpiego has been awarded a $55 million five-year cooperative agreement from the U.S. Agency for International Development to collaborate on the implementation of Expanding Maternal and Neonatal Survival in Indonesia. The EMAS program will improve quality of maternal and neonatal

Editor Lois Perschetz Writer Greg Rienzi Production Lynna Bright Copy Editor Ann Stiller P h o t o g r aph y Homewood Photography

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health services at 150 hospitals and increase efficiency and effectiveness in referral systems between their 300 community health centers and hospitals.

Partners in the Jhpiego-led team include Budi Kemuliaan Maternal and Child Health Hospital, Muhammadiyah, Save the Children and RTI International. To maximize and extend results, the international partners will leverage corporate partnerships with sponsors such as ExxonMobil, Chevron, General Electric Healthcare, Starbucks, Kraft, Coca-Cola, Project Cure, Laerdal and AT&T.

Three Jays named to Academic All-America Football Team

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resh off one of the greatest seasons in school history, the 2011 Johns Hopkins football team continued to roll in honors last week as the Blue Jays had three players named to the 2011 CoSIDA/Capital One Division III Academic All-America Football Team.

Senior tackle Roland Massimino was named to the first team, while senior guard Doug Drummond and senior defensive end Kale Sweeney earned second team honors.

With three selections, Johns Hopkins is tied with Mt. Union for the second-most among all Division III schools, and JHU’s all-time total of Academic All-America football players has been raised to 15.

Johns Hopkins posted a 10-1 record, won the Centennial Conference title and advanced to the NCAA playoffs this season.

The Blue Jays were ranked in the top 25 throughout the season and had a schoolrecord 15-game winning streak before falling in the first round of the NCAA playoffs.

The Centennial Conference title was the third straight and seventh in the last 10 years for Johns Hopkins.

Online J-List offers housing listings, discussion forums

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he Office of Work, Life and Engagement has launched J-List, an online resource providing housing classifieds and discussion forums.

Johns Hopkins faculty, staff, students and retirees who want to buy, sell, rent or share their home can list them on the site, and users will be able to search the database by home type and ZIP code. Listings will include property descriptions, pictures and contact information, and will remain posted for 60 days, unless removed by the owner.

The resource also includes discussion forums on child care, parenting, elder care and more. Users can create, respond and subscribe to threads in the discussions.

To log onto the site, go to www .hopkinsworklife and select J-List from the left-side navigation. You will be prompted to enter a JHED ID and password and asked to agree to the terms and conditions of the site.

Contributing Writers Applied Physics Laboratory Michael Buckley, Paulette Campbell Bloomberg School of Public Health Tim Parsons, Natalie Wood-Wright Carey Business School Andrew Blumberg, Patrick Ercolano Homewood Lisa De Nike, Amy Lunday, Dennis O’Shea, Tracey A. Reeves, Phil Sneiderman Johns Hopkins Medicine Christen Brownlee, Stephanie Desmon, Neil A. Grauer, Audrey Huang, John Lazarou, David March, Vanessa McMains, Ekaterina Pesheva, Vanessa Wasta, Maryalice Yakutchik Peabody Institute Richard Selden SAIS Felisa Neuringer Klubes School of Education James Campbell, Theresa Norton School of Nursing Kelly Brooks-Staub University Libraries and Museums Brian Shields, Heather Egan Stalfort

The Gazette is published weekly September through May and biweekly June through August for the Johns Hopkins University community by the Office of Communications and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscriptions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date.

Phone: 443-287-9900 Fax: 443-287-9920 General e-mail: gazette@jhu.edu Classifieds e-mail: gazads@jhu.edu On the Web: gazette.jhu.edu Paid advertising, which does not represent any endorsement by the university, is handled by the Gazelle Group at 410343-3362 or gazellegrp@comcast.net.

December 12, 2011 • THE GAZETTE

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K U D O S

Bioethicist Ruth Faden receives lifetime achievement award B y L e ah R a m s e y

Berman Institute of Bioethics

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uth Faden, founding director of the Johns Hopkins Berman Institute of Bioethics, is a co-recipient with her husband, bioethicist Tom L. Beauchamp, of the Lifetime Achievement Award for Excellence in Research Ethics from Public Responsibility in Medicine and Research.

The award, presented Dec. 3 at the 2011 Advancing Ethical Research Conference at the Gaylord Hotel in National Harbor, Md., is given for work that has “embodied a unique and profound commitment to advancing research ethics.” Past recipients include Jay Katz, Charles McCarthy, Robert Levine and Al Jonsen.

“Ruth and Tom are respected leaders, visionary thinkers and role models to us all,” said Joan Rachlin, executive director of PRIM&R. “Those in the bioethics field have already benefited, and will continue to benefit, from their individual and collective wisdom and experience.”

In addition to her leadership of the Berman Institute since 1995, Faden is the Philip Franklin Wagley Professor of Biomedical Ethics, a professor in the Department of Health Policy and Management at the Johns Hopkins University Bloomberg School of Public Health and a professor in the Department of Medicine at the Johns Hopkins University School of Medicine.

“I am thrilled to be a recipient of this award,” said Faden, who taught what is believed to be the first public health ethics

course in the country. “It is an extraordinary honor, and extraordinary to be sharing it with my husband. Scholarship on the ethics of research is one of the core strengths of the Berman Institute, and if my work is worthy of recognition, it is because I have such wonderfully talented colleagues.”

Among their extensive collaborative work and individual achievements, Faden and Beauchamp co-authored A History and Theory of Informed Consent, which was published by Oxford University Press in 1986 and is still widely regarded as the most authoritative and comprehensive work on informed consent.

“I can think of no more fitting recipients of the PRIM&R Lifetime Achievement Award than Ruth Faden and Tom Beauchamp,” noted Jeffery Kahn, who joined the Berman

Institute as deputy director for policy and administration earlier this year after serving as director of the bioethics program at the University of Minnesota medical school.

“Their scholarship in the ethics of research on human subjects is the most important of the last 30 years, and a testament to the power of collaboration by two scholars of immense individual talent and insight.”

Kahn said that Faden and Beauchamp’s “seminal book on informed consent is as fresh and relevant today as it was when it was published in 1986, and is but one example of their landmark contributions to our field.”

In October, Faden was honored with a Lifetime Achievement Award from the American Society for Bioethics and Humanities for her work on social justice issues in health policy.

Ovary removal in young women linked to bone thinning, arthritis B y J i m S c h n ab e l

Johns Hopkins Medicine

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aving both ovaries removed before age 45 is strongly associated with low bone mineral density and arthritis in later years, according to a new study by Johns Hopkins oncologists and epidemiologists. The analysis covered several thousand women who took part in a U.S. government–sponsored multiyear national health study, and excluded women whose ovaries were removed due to cancer.

“This is one of the largest national studies, to my knowledge, that highlights the difference in bone-mineral density in women who have their ovaries removed at a young age. Our results suggest that such women should be monitored closely for osteoporosis,” said Kala Visvanathan, an associate professor of oncology and epidemiology at the Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Kimmel Cancer Center. Results of the study were presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 6 to 10.

Since ovary removal, known as oophorectomy, is recommended to reduce ovarian and breast cancer risk in women at high risk for these diseases, the investigators were interested in studying its long-term effects on bone health. Oophorectomy also is a common procedure in women who undergo hysterectomy, or womb removal. Each

year in the United States, about 600,000 women undergo a hysterectomy, and about half of these women also have both ovaries removed. Hysterectomy is commonly performed in middle-aged women to treat symptoms of pain or bleeding caused by conditions such as fibroids, endometriosis or uterine prolapse, or cysts. Women having hysterectomies for these benign conditions may have their ovaries removed at the same time, believing that the additional step will reduce cancer risk, according to Visvanathan.

Regardless of the reason for such surgery, however, the procedure has adverse effects, the Johns Hopkins researchers say. Levels of estrogens and related hormones that are normally produced by the ovaries fall steeply after oophorectomy, abruptly bringing on menopause in women who are not yet menopausal. Estrogens help protect the body from aging and age-related disease, and physicians and epidemiologists over the past two decades have linked their premature loss to increased risks of parkinsonism, dementia, arthritis and the brittle-bone condition known as osteoporosis.

For the study, Anne Marie McCarthy, a PhD candidate at the Bloomberg School, and Visvanathan used existing information from a health research database called the third National Health and Nutrition Examination Survey, or NHANES III. The information was gathered as part of a U.S.sponsored epidemiological study conducted from 1988 to 1994; among other health measures, it includes data from standard

X-ray-based measure of bone mineral density in the hip and spine for thousands of women. “Using the NHANES III data, we set out to measure bone mineral density in women who’d had a bilateral oophorectomy compared with women with intact ovaries,” McCarthy said.

Of the data on 34,000 Americans ages 2 months and older included in the NHANES III study, McCarthy focused on more than 3,700 women age 40 and over with no history of cancer. Most had intact ovaries; of the 560 women who had oophorectomy, about half had surgery before age 45.

McCarthy found that women who had both ovaries removed before age 45 had on average 3 percent lower bone mineral density than women with intact ovaries.

McCarthy examined arthritis risk, too, and found that 48 percent of women who had oophorectomies before age 45 reported an arthritis diagnosis, compared with only 32 percent for those with intact ovaries.

When McCarthy excluded women who had taken hormone replacement therapy, which normally counters the effects of lost ovarian hormones, these added risks became even higher. “Women who had had a bilateral oophorectomy before age 45 and didn’t take HRT were about twice as likely to get arthritis and three times as likely to have low bone mineral density, compared with those with intact ovaries,” she said.

The NHANES III data represent snapshots of subjects’ health and do not conclusively establish that oophorectomy causes

lower bone mineral density, according to the researchers. But the Johns Hopkins researchers’ analysis is consistent with previous studies, they say, and strongly suggests that oophorectomy can accelerate agerelated conditions, such as osteoporosis, and thus shouldn’t be done without a clear medical reason. “The key factor may be the abrupt removal of ovarian hormones, in contrast with natural menopause, in which there is a gradual decline, but that’s something we need to study further,” Visvanathan said.

Women with cancer and other medical conditions that necessitate oophorectomy, and women with specific genetic mutations that bring extremely high ovarian cancer risk, should still get their ovaries removed, she added. “But they should be monitored closely for early signs of low bone mineral density so that osteoporosis can be prevented with the appropriate treatments.”

The research was funded by the Breast Cancer Research Foundation.

Related websites Kimmel Cancer Center at Johns Hopkins:

www.hopkinskimmelcancercenter .org

CTRC-AACR San Antonio Breast Cancer Symposium:

www.sabcs.org

Degrees of failure: Many high school graduates are unprepared B y A m y L u n d ay

Homewood

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significant number of American teenagers graduate from high school unprepared to take their next big steps toward adulthood, according to a study by researchers at The Johns Hopkins University and the University of Arizona’s Center for the Study of Higher Education.

More than 40 percent of high-schoolers do not follow a college preparatory track or take adequate career and technical education courses, and these missed opportunities can leave young people at a disadvantage after graduation when they enroll in college or look for a job, according to Stefanie DeLuca, an associate professor in the Department of Sociology at Johns Hopkins, and Regina Deil-Amen, of the University of Arizona.

“This group is a virtual underclass of students who are neither college-ready nor in an identifiable career curriculum,” DeLuca said. “They are likely to depart from high

school having taken classes mainly from the high school general curriculum in which they received little to no job preparation or guidance. This group is also less likely to enroll in college, but if they do, they enroll at a remedial level and leave before earning a degree. Either path places them at risk for failure.”

DeLuca and Deil-Amen’s study, “The Underserved Third: How Our Educational Structures Populate an Educational Underclass,” was published by the Journal of Education for Students Placed at Risk in April 2010.

Analyzing data from the National Educational Longitudinal Study along with other studies, DeLuca and Deil-Amen found that today’s high-schoolers fall into three categories: those on a college preparatory track, making up an estimated one-third of the student body; those who prepare for the post-graduation labor force through career and technical education programs, making up a quarter of the student population; and the more than 40 percent of high school students who don’t have access to adequate

college preparation or occupational training.

The college-track students were disproportionately white and of higher socioeconomic status, and the most unprepared students were the poorest, disproportionately underrepresented minority students, immigrant English language learners and first-generation college students.

For some students who delay preparation for four-year colleges or jobs while in high school, two-year colleges seem like a second chance. Some students manage to meet the requirements for highly selective two-year community college programs or make it through expensive occupational programs at for-profit colleges; both options can prepare them for more-lucrative jobs. However, many others end up in less-selective two-year degree programs and often don’t complete the requirements. When they do, such programs may lead to less economically rewarding jobs, DeLuca and Deil-Amen wrote.

“Unfortunately, many who seek a concrete route to a good job pay the high cost of for-profit colleges when the same programs

are often offered at a much lower cost in community colleges or state universities,” DeLuca said. “Nowhere is there a safety net to prevent these youth from falling through the cracks in the two-year pipeline. They leave demoralized, having spent time and money with no clear job skills or credentials to show for it.”

To combat these problems, the researchers support the fusion of career and academic curricula in high school to provide more feasible methods of opening up career and college options for all.

“College access has increased dramatically, but to parade enrollment in higher education as a guaranteed pathway to social mobility is illusory,” DeLuca and Deil-Amen said. “To imagine that youth in poverty can be upwardly mobile via college access denies the fact that the education system positions them to be members of an educational underclass and ensures that they experience a structured lack of opportunities.”

The complete article is available online at www.soc.jhu.edu/people/DeLuca/documents/ D_%20D_%20JESPAR.pdf.

4 2011 4 THE THE GAZETTE GAZETTE •• December August 15,12, 2011

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of the Krieger School of Arts and Sciences, formed an Academy Planning Committee in early 2011 and appointed faculty members to discuss the possibility that an institute for advanced study could create

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pacious apartment living set in a prestigious hi-rise building. Adjacent to Johns Hopkins University Homewood Campus and minutes from downtown Baltimore. Amenities include an on-site restaurant, salon and convenience store.

he Johns Hopkins University has established a new named professorship in civil engineering supported by an endowment set up by Michael G. Callas, a leading Maryland structural engineer, who died in 2004.

The university recently conducted a ceremony to recognize the gift and to designate Somnath Ghosh as the inaugural Michael G. Callas Professor of Civil Engineering in the Whiting School of Engineering. Ghosh joined the Whiting School faculty this year after two decades at The Ohio State University. He holds joint appointments in the Whiting School’s departments of Civil Engineering and Mechanical Engineering and directs the university’s Computational Mechanics Research Laboratory.

“Dr. Ghosh is a world-class researcher in civil engineering and computational mechanics, and the Callas Professorship was instrumental in recruiting him to come to Johns Hopkins,” said Nicholas P. Jones, the Benjamin T. Rome Dean of the Whiting School. “An international search was conducted, and we look forward to his great work with other faculty and students.”

Endowments such as this provide financial

Somnath Ghosh

support for a faculty member’s research and teaching efforts, and can be used to support the work of the professor’s graduate students.

It continues as long as the faculty member remains in his post. If the professor retires or leaves the university, the endowment can be awarded to another faculty member.

University officials said that Callas began contributing toward the new civil engineering professorship in 1989 and made provi-

stronger connections between retired faculty and the university community. The committee was co-chaired by Betsy Bryan, the Alexander Badawy Professor of Egyptian Art and Archaeology in the Department of Near Eastern Studies, and William Connolly, the Krieger-Eisenhower Professor of Political Science.

The committee’s other members were Maurice Bessman, a professor emeritus in the Department of Biology; Jane Guyer, the George Armstrong Kelly Professor and chair of the Department of Anthropology; Richard Kagan, the Arthur Oncken Lovejoy Professor in the Department of History; and Warren Moos, a research professor in the Department of Physics.

Members of the Faculty Planning Committee and Dean Newman will host town hall meetings for anyone interested in The Academy from 1 to 2:30 p.m. today, Dec. 12, in 132 Gilman and again in early February (date and time TBA) to field questions.

Newman said that the academy professors will become a rich source of knowledge and experience, and a vital element of the university’s intellectual community.

“Our retired colleagues are actively engaged in their scholarly work and remain a vital element of the university’s intellectual community. For academics, The Academy is everything retirement should be,” Newman said.

Faculty over the age of 55 with 10 or more years of experience, or who have 30 years of experience regardless of age, can declare their intention to retire and become academy professors. Applications can be filed as of this month.

Additional criteria for appointment include an intention to participate in the activities of The Academy and a plan to continue a research program or pursue a research or scholarly interest.

Membership benefits include an annual research allowance of $2,000; shared office space if available in home departments or The Academy building, as determined by

Deadline is today, Dec. 12, for last ‘Gazette’ issue of semester

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ecause of the midyear vacation, The Gazette will not be published the weeks of Dec. 26 and Jan. 2.

Next week’s calendar will include events scheduled from Monday, Dec. 19, through Monday, Jan. 9. The deadline for calendar and classifieds submissions for that issue is noon today, Dec. 12. The deadline for the Jan. 9 issue is Friday, Dec. 30.

sions in his will to fully fund the endowment through a bequest. The Callas gift established the 21st named professorship in the Whiting School.

Callas had longtime ties to Johns Hopkins, earning a bachelor’s degree in civil engineering in 1943 and a master’s degree in structural engineering in 1947. He worked for the Whiting-Turner Contracting Co. and then, in 1958, founded Callas Contractors, a Hagerstown, Md.–based general contracting firm that takes part in the construction, repair and remodeling of buildings and public works projects. He served on the Whiting School’s National Advisory Council and the Civil Engineering Visiting Committee. In 1992, the Johns Hopkins Alumni Association recognized Callas for his contributions to the university with its Heritage Award.

Callas also was recognized for his community service. In 1998, the Mason-Dixon Boy Scouts presented him with its Distinguished Citizen Award, and Gov. Parris Glendening awarded him a Governor’s Citation for his years of community service and his commitment to the state’s young people.

In addition, he was active in the Hagerstown–Washington County Chamber of Commerce, where he served as president and regional director and was 1992 Volunteer of the Year and chairman of the Business-Education Partnership Committee.

department chairs or The Academy’s governing committee; full library privileges; and administrative support. Tenured KSAS faculty who elect retirement on or after Dec. 1, 2011, are also eligible for a health care incentive stipend.

The research allowance, available for a maximum period of 10 years, may be used to support expenses incurred in connection with scholarly activities.

The Academy’s annual budget will support seminars, lectures, workshops, a speaker series and visiting members. The Academy will host up to four retired visiting scholars from other universities for one-year appointments.

A governing board with representation from the academic divisions of KSAS divisions will oversee The Academy. Members will choose a chair, to serve for two years, who will report to the dean of the Krieger School.

Initial appointments to The Academy will be three years in duration and may be renewed annually thereafter. Eligibility continues for 10 years, provided the retired faculty member is an active participant in The Academy.

Architectural drawings and progress reports on the Greenhouse’s renovations will be posted periodically on The Academy’s website, located at krieger2.jhu.edu/ theacademy.

“I’m so pleased that we will be able to turn the Greenhouse and the brick buildings connected to it into a truly stately home for The Academy, befitting the stature of the professoriate who will be working there,” Newman said of the facility, which is located behind Gilman Hall.

Bryan said that the committee wanted to look into ways to keep productive and talented faculty connected to Johns Hopkins.

“Retired faculty members often lose connection with the university sooner than they might otherwise, despite their continued scholarly activity,” Bryan said. “The Academy will enable the entire Johns Hopkins community to benefit from the involvement of retired faculty on campus.”

Connolly noted that The Academy would be a novel addition to higher education, as there is no other institute of its kind in the United States.

“Not only does it redefine retirement for our faculty members, but The Academy also provides an invaluable intellectual forum, instigated by its professors, that engages the larger Hopkins community,” he said.

Tenured faculty members who retired before 2010 are invited to participate in the activities of The Academy but will not be eligible for the research allowance or the title of academy professor. G

December 12, 2011 • THE GAZETTE

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By withholding trust in negotiations, parties ‘pay a price’ B y P at r i c k E r c o l a n o

Carey Business School

GIS Continued from page 1 Across campus in Steve Hellen’s new Introduction to Geographic Information Systems and Geospatial Analysis course, a student uses gridded maps overlaid with population data to show the areas at risk of flooding in New Orleans. Another student, for his final project, uses maps and data to locate the greatest congestion of restaurants near the Homewood campus.

All these students developed their presentations using geographic information systems technology, or GIS, the buzzword of the moment on the Homewood campus, due to a grassroots effort led by new faculty in the Krieger School of Arts and Sciences and the Whiting School of Engineering.

What started as a relatively small group expressing interest in the expanded use of the technology has grown into a broader initiative for the formation of a Geospatial Sciences Teaching and Research Facility. The first two components of this initiative, a geospatial analysis teaching lab and a foundation GIS course, were implemented this fall.

Darryn Waugh, the Morton K. Blaustein Professor and Chairman of the Department of Earth and Planetary Sciences, said that geospatial-related activities are becoming increasingly important for many disciplines, including engineering, social sciences and humanities.

“A growing number of Johns Hopkins faculty, postdocs and students use geospatial analysis as part of their research,” Waugh said.

“There was an immediate need for the teaching lab and introductory course, and once we have shown the need and success of these efforts, I hope there will be further discussion on the formation of the broader facility.”

GIS, which traces its roots to the early 1960s, is roughly speaking a system for managing and analyzing spatial information. GIS merges cartography, statistical analysis and database technology to allow the user to capture, store, manipulate, analyze and manage and then visually display all manner of geographically referenced data.

The technology is commonly used by researchers and professionals in many fields, including public health, archaeology, sociology, environmental sciences, civil engineering and other areas.

In recent years, the departments of Earth and Planetary Sciences, Civil Engineering

CHRIS HARTLOVE

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tudies have long documented that people from different cultures negotiate in different ways, though it is unclear why this happens. But a new research paper argues that different levels of trust account for these divergent bargaining strategies, with negotiators from less-trusting cultures engaging in counterproductive behaviors that lead to poor outcomes.

Recently published in the Journal of Applied Psychology, the paper is made timely by economic globalization and the resulting frequency of financial and political negotiations between parties of various nationalities and cultures, notes lead author Brian Gunia, an assistant professor in the Johns Hopkins Carey Business School.

The findings also could be applied to the lack of trusting discourse between the two major political parties in Washington, D.C., according to Gunia, whose research focused on American and Indian negotiators.

“At the end of the day, this isn’t so much about culture as it is about the central issue of trust—how negotiators from any society should develop more of a trustbased approach that helps produce understanding, insight and joint gains for the parties on both sides of the table,” Gunia said. “Whether it involves executives in India discussing business deals or members

Brian Gunia

of the United States Congress addressing the budget deficit, the goal of negotiating should be beneficial outcomes and strong relationships. Negotiators will only achieve that when they trust one another and thus exchange enough information to achieve beneficial results all around.”

For the paper, titled “Paying a Price: Culture, Trust and Negotiation Consequences,” Gunia and his co-authors conducted three studies with MBA students and business managers in the United States and India.

The students were asked a series of questions about how they would define trust and how

and Near Eastern Studies have hired young faculty well versed in the use of geospatial analysis. But the new hires found a campus relatively bereft of GIS resources, and decided to do something about it.

With the assistance and facilitation of the Center for Educational Resources, an informal GIS summit was held last fall. Out of these meetings came a proposal for a GISdedicated facility on the Homewood campus.

Fred Puddester, then senior associate dean for finance and administration at the Krieger School, heard the call and authorized the funding for a geospatial teaching lab, which opened this semester in Dunning Hall.

Fred Thomsen, IT manager for the Krieger School, led the design and installation of the lab, which features 25 computer workstations and an Internet bandwidth intensity robust enough to process the massive amounts of data used by the geospatial software.

Four courses were taught there this fall.

Steve Hellen, director of Academic Technology for the university and a lecturer in Earth and Planetary Sciences, taught the Introduction to Geographic Information Systems and Geospatial Analysis course.

Hellen, an expert on GIS technologies, said that the class “worked out phenomenally well” and gave the students a good grounding in the use of the computer-based tools.

“They learned how data were structured, and how they can interact with the data and then perform spatial analysis, which is the heart of what GIS does,” Hellen said. “We set the foundation, and then the students each picked a project to perform their own spatial analysis.”

Some key aspects of GIS are the use of maps, layering and vector data. Through software, users can stack layers of data such as elevations, street maps, land use, hydrography, satellite imagery, population density and other visually represented information.

One of Hellen’s students conducted an analysis of poverty statistics in the Midwest, while another performed an examination of the environmental risks of hydraulic fracturing in Pennsylvania.

Other faculty in the Krieger and Whiting schools are teaching discipline-specific courses that integrate GIS into assignments.

In Becker’s Population Health and Development class, students used global health data and GIS technologies to conduct mini research projects they presented to the class.

Benjamin Zaitchik, an assistant professor in Earth and Planetary Sciences, taught Remote Sensing of the Environment.

willingly they would extend trust during a negotiation. The business managers held simulated negotiations over the sale of rerun rights for a cartoon TV series.

The U.S. and India offer an instructive contrast between bargaining styles and how trust governs negotiations. As explained by Gunia and his colleagues—Jeanne Brett of Northwestern University and Amit Nandkeolyar and Dishan Kamdar of the Indian School of Business—the United States and many other Western nations can be described as “loose” cultures, while India and other Eastern countries are referred to as “tight” cultures.

In the loose cultures of the West, negotiators generally assume that their counterparts are trustworthy until they prove otherwise. This assumption leads them to share information in a way that produces mutual insight and, ultimately, mutual benefits. In the tight cultures of the East, negotiators generally assume that their counterparts are untrustworthy until they show otherwise, as trust there is typically vested in rules rather than in individuals. This leads them to spend more time exchanging and substantiating offers than in understanding the needs of their counterparts, a strategy that can diminish potential gains.

The results of the three studies confirmed these descriptions and how they applied to the American and Indian participants.

Although they agreed on definitions of trust and distrust, American negotiators said that

they would trust (and did trust) more than Indian negotiators did, achieving better outcomes as a result. Americans saw trust as a natural element of the bargaining process, while Indian negotiators registered doubt about their counterparts’ intentions.

“It seems likely that these beliefs and values are functional within each culture and resistant to change,” the authors noted in the paper. “Nevertheless, our results highlight the importance, for Indian and American managers and their counterparts, of understanding negotiators’ cultural orientation toward trust. … The practical question that arises is how negotiators tending toward low trust, which may include Indians and others from tight cultures, can avoid leaving joint gains on the table.”

A possible answer, the paper suggests, is “to train negotiators to signal their own trustworthiness and to analyze whether their counterparts are reciprocating.” Also, low-trust negotiators could be taught to signal their priorities implicitly through offers, rather than through an explicit discussion requiring trust.

Such lessons could prove useful even in a loose culture like America, Gunia observed in an interview. “Just look at the recent talks in Congress over the deficit,” he said.

“There we’ve seen how the lack of trust between the two major political parties has created a take-it-or-leave-it mentality that has led nowhere, as opposed to a more open approach in which the goals of each side could be stated and openly discussed.”

Michael Harrower, an assistant professor of archaeology in Near Eastern Studies, joined Johns Hopkins in 2010 and was part of the group that championed the further use of GIS at Homewood. He will teach GIS in Archaeology in the spring.

Harrower’s current fieldwork in Ethiopia and Oman concentrates on landscape-scale political complexity, and he often employs GIS technology in his work.

“GIS use and satellite imagery have become centrally important to what archaeologists do,” Harrower said. “Quite a number of new faculty here are interested in GIS. We all recognized a shortage of computer facilities needed to teach GIS to students.

It’s been a group effort to create this new lab.

Faculty from two Krieger and two Whiting departments—myself, Ben Zaitchik in Earth and Planetary Sciences, Peter Wilcock in Geography and Environmental Engineering and Judy Mitrani-Reiser in Civil Engineering—worked in close consultation, along

with staff and administrators of the library.”

Speaking to the popularity of GIS use, Harrower said that you don’t have to look further than your Web browser and how we get around these days.

“Many of us now have GPS in our cars, and then there’s Google Earth and Google Maps. Esentially, these are rudimentary forms of GIS,” Harrower said. “GIS can be applied in all sort of disciplines. Almost any type of data has a spatial component—for example, a street address or a specific latitude and longitude.”

In the near future, the Sheridan Libraries’ Department of GIS and Data Services hopes to expand GIS capacity in the Milton S. Eisenhower Library, which currently has six stations outfitted with ArcGIS and staff who have expertise with the software. G For more information on the library’s GIS resources, including training and how to load a copy of the ArcGIS software, go to guides .library.jhu.edu/gis.

Alexander Szalay wins Microsoft’s Jim Gray eScience Award

By Lisa De Nike

Homewood

J

ohns Hopkins astrophysicist and computer scientist Alexander Szalay, a national leader in advancing understanding of the role of computing in discovery across a wide range of scientific disciplines, has been recognized by the Microsoft Corp. with a Jim Gray eScience Award.

Szalay, the Alumni Centennial Professor in the Henry A. Rowland Department of Physics and Astronomy, and director of the university’s Institute for Data Intensive Engineering and Science, received the award during Microsoft’s annual eScience Workshop, held last week in Stockholm.

Established in 2008 as a tribute to the late Jim Gray, a technical fellow for Microsoft Research who disappeared at sea in 2007, the award recognizes a researcher who has made outstanding contributions to the field of data-intensive computing.

Szalay worked with Gray on a number of projects, including the Sloan Digital Sky Survey, an international collaboration of more than 100 scientists and engineers that

aims to map one-quarter of the sky to create a systematic, three-dimensional picture of the universe.

“Jim and I had an amazing journey in collaborating on Big Data and how it is revolutionizing the way we do science. We talked on the phone several times every day, and we wrote tens of thousands of lines of code together. Jim Gray was a very special person, and the award has a special significance for me,” Szalay said.

Microsoft honored Szalay with a technical computing award for his contributions to eScience in 2007, before the award was named for Gray. He will now officially be honored as a Jim Gray Award recipient, along with the 2011 award winner, Mark Abbott, dean of Oregon State University’s College of Earth, Ocean and Atmospheric Sciences.

“Alex’s groundbreaking partnership with Jim Gray set the stage for the advancement of the field of eScience across a range of scientific domains,” according to Harold Javid, director of Regional Programs at Microsoft Research Connections. “He was chosen as a Jim Gray eScience Award winner for his foundational contributions to interdisciplinary advances in the field of astronomy.”

6 2011 6 THE THE GAZETTE GAZETTE •• December August 15,12, 2011 R E C O G N I T I O N

Theater in Homewood’s Merrick Barn named for John Astin B y K at e P i p k i n

Krieger School of Arts and Sciences

will kirk / homewoodphoto.jhu.edu

J

ohns Hopkins University has honored John Astin by naming the recently renovated theater in the Merrick Barn after the noted actor and teacher. The naming took place Dec. 3 at an event celebrating the completion of renovations to the barn, and recognizing Astin’s 10-year anniversary of teaching, acting and directing at Johns Hopkins.

Notable actor Ed Asner, Astin’s longtime friend, was master of ceremonies for the event, which featured the performance of two one-act plays by some of Astin’s students. Among the audience members were Astin’s two actor sons, Sean and Mackenzie, and his wife, Valerie.

After the performances, President Ronald J. Daniels made the surprise announcement.

“In recognition of your exceptional work not only on stages worldwide but also here at Johns Hopkins, we are delighted to name this theater in the Merrick Barn in your honor,” Daniels said. “The John Astin

Ed Asner, John Astin, Katherine Newman and Ron Daniels

Theatre in the Merrick Barn will be a permanent embodiment of your tremendous legacy already so beautifully reflected in the artistry of the students you have taught and the joy of audiences you have touched.”

JHM International signs MOU with Peru’s Pacifico Salud

J

ohns Hopkins Medicine International and Lima, Peru–based Pacifico Salud, a subsidiary of Credicorp Ltd., the leading financial services holding company in Peru, have signed a memorandum of understanding to improve patient care and management at the medical facilities recently acquired by the Peruvian company.

Under the terms of the agreement, signed Dec. 2, in Lima, Johns Hopkins Medicine International and Pacifico Salud will focus on improving patient safety, management and the quality of health care delivery to provide the best experience for patients.

“We are very proud to have signed this memorandum of understanding, which represents a turning point in the history of Peruvian health care,” said Guillermo Garrido Lecca, general manager of Pacifico Salud. “Johns Hopkins is one of the most prestigious medical groups in the world, and their involvement will enable us to achieve the highest standards of medical excellence for the benefit of our community.”

Beginning in January, Johns Hopkins will assess the hospitals’ strengths and provide a gap analysis of Pacifico Salud’s health care facilities.

Astin said he was “shocked, stunned and, of course, delighted and grateful.”

“I believe the recognition has come about through the achievements of the current students and the successes, after graduation, earned by those who have gone through the program and participated in the university theater,” Astin said. “Much of the credit belongs to our small but wonderful faculty and staff, supporters and parents, and to the vision of President Ron Daniels and Krieger School Dean Katherine Newman. I am stoked! They have energized and inspired me with this exquisite gesture, and I feel that it could be the catalyst that propels us toward the theater major we have long desired for Johns Hopkins.”

Astin is best known for the role of Gomez Addams on the television show The Addams Family. After majoring in drama at Johns Hopkins and graduating in 1952, Astin started in theater on Broadway. His first big break in film came with a part in West Side Story in

1961. His talent for comedy led him to roles in several television sitcoms. He received an Academy Award nomination for Prelude, a short film he wrote, produced and directed.

Astin returned to Johns Hopkins in 2001 to teach acting and directing and to revitalize the undergraduate program in theater arts.

“John’s vision for the Program in Theatre Arts and Studies has shaped it into an extraordinary program that empowers students on the stage and off,” Newman said.

“His enthusiasm is contagious, and the talent he continues to share with us will forever live on in this theater that bears his name.”

The John Astin Theatre is housed in a former dairy cattle barn built by Charles Carroll Jr. in the early 19th century and converted into a student center after the university moved to the property that had been Carroll’s country villa. In 1983, it was formally named the Merrick Barn in honor of Robert G. Merrick, a 1917 alumnus and 1922 PhD recipient. Today, the Merrick Barn is home to the Undergraduate Program in Theatre Arts and Studies.

Over the years, the main theater seating and flooring had become threadbare, and the proscenium needed renovation. Thanks to the generous support of the France-Merrick Foundation and other patrons, $210,000 was raised for a renovation project that was completed this summer. Improvements included replacing the theater’s lighting and its 104 seats; new flooring, paint and furnishings throughout the building; and various other improvements to create a better theater environment for students while enhancing the audience experience.

Between 120 and 160 students enroll each semester in courses that include acting, directing, play writing, stagecraft and theatrical and literary appreciation. Two or three productions are presented in the Merrick Barn each semester for audiences from the Homewood and Baltimore communities.

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December 12, 2011 • THE GAZETTE

7

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umerous polls show that recent college grads have been hit hard by the recession and are facing tough odds in finding well-paying employment.

Others show the classes of 2010 and 2011 to be underemployed, with many not finding jobs in their preferred fields or geographic locations.

Nursing grads might be proving to be the exception. A recent survey of nursing schools conducted by the American Association of Colleges of Nursing tells a story of success for recent graduates. Among those receiving a nursing bachelor’s degree, 88 percent have received job offers within four to six months; of those earning a master’s, 92 percent have found work.

At the Johns Hopkins University School of Nursing, informal online surveys of the 2010 graduates show a similar percentage, with 89 percent of respondents from all programs (bachelor’s, master’s, PhD and Doctor of Nursing Practice) indicating that they have found jobs; of the 11 percent not employed, nearly 10 percent indicated they were pursuing an advanced degree full time.

The Johns Hopkins survey also showed that nearly two-thirds of the respondents found positions within 90 days following graduation, and an additional 24 percent, within six months; only 8 percent indicated their search took longer.

Many of the myths surrounding employment for new nurses are being exploded by the AACN and Johns Hopkins data—myths that may have dissuaded some prospective students from seeking a nursing education and that include misconceptions about extreme difficulty with the employment search, hiring freezes at hospitals, geographic areas oversupplied with nurses and new nurses being hired to do lower-level health care.

Among Johns Hopkins grads, only 11 percent reported the job search to be very difficult, while 19 percent reported no difficulty at all. The highest percentage of respondents (71 percent) described their job search as slightly to moderately difficult. The majority of survey respondents (58 percent) found their first choice in a position, and 66 percent in their preferred geographic location. Ninety-one percent were employed by hospitals.

Sandra Angell, associate dean for student affairs at the Johns Hopkins School of Nursing, says that she is finding similar, if not slightly better, results among early responses from the classes of 2011. “The jobs are there, and they’re good positions in excellent health care facilities. It might take a little longer, a bit more persistence, and occasionally a graduate might have to take his or her second choice in position or location,” she said.

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Nursing grads beat employment odds, debunk hiring myths

Hodson Trust awards Johns Hopkins nearly $2 mill

T

he Hodson Trust this month awarded nearly $2 million to Johns Hopkins University to support undergraduate scholarships, research in oncology and nephrology, and the Hodson Curator of the University Archives. The grant was awarded Dec. 1 following the annual Hodson Scholars Luncheon, at which two students expressed their gratitude for the Hodson Trust’s support.

Pictured are Hodson Trust Chairman Gerald L. Holm, Hodson-Gilliam Success Scholar Dominique Marshall, Hodson Scholar Hugo Cervantes and Johns Hopkins President Ronald J. Daniels.

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Since its inaugural grant to Johns Hopkins in 1958, the Hodson Trust has given the university more than $74 million, mostly for undergraduate scholarships and for the construction of Hodson Hall.

The Hodson Trust was settled in 1920 by the family of Col. Clarence Hodson, who grew up in Maryland. Hodson believed that financial credit should be available to the average American, a revolutionary idea in 1914, when he founded the Beneficial Loan Society. Beneficial became part of Household International, now HSBC, in 1998.

8 2011 8 THE THE GAZETTE GAZETTE •• December August 15,12, 2011

Reports cite must-have sexual health services for teen boys B y E k at e r i n a P e s h e va

Johns Hopkins Medicine

T

wo newly published reports by investigators at the Johns Hopkins Children’s Center highlight the need for greater recognition of the sexual and reproductive health care needs of teen boys, and enumerate the essential services that this traditionally overlooked group should receive at least once a year.

The first report, published in the December issue of Pediatrics, underscores what experts say is the glaring absence of guidelines on what sexual health tests and screening procedures teenage males should get and how often. The article offers a list of clinical practice recommendations to help fill that gap.

“Many clinicians currently forgo delivering some or many of these services because of limited time during visits, lack of evidence on the benefit of doing so and absence of guidelines on how to go about it,” says lead author Arik Marcell, a teen health expert at Johns Hopkins.

Indeed, Marcell notes, primary-care pediatricians are three times more likely to take a sexual history from girls than from boys, and twice as likely to discuss with girls as

with boys the importance of condom use.

Yet past research shows that 75 percent of U.S. male teens report having a sexual encounter by the time they are 18, have more sexual partners than girls and have sex at an earlier age than girls, he adds. In addition, Marcell and colleagues note, past research shows that many teen boys engage in high-risk sexual behaviors, including sex while drunk or high on drugs (26 percent), unprotected sex (nearly 30 percent) and having sex with an HIV-infected person or a prostitute (6 percent), according to one study.

The second report, a study published online Dec. 5 in the Journal of Adolescent Health, identifies what clinicians deem core sexual and reproductive services that every male teen should receive during annual physical exams.

The findings, based on interviews with 17 primary-care clinicians who specialize in male teen health, recommend a physical that includes a genital exam to assess pubertal growth and screen for inherited disorders of sexual differentiation, such as Klinefelter syndrome and fragile X syndrome, as well as for nonsexually transmitted diseases that can affect sexual function and reproduction; screening and counseling for sexually transmitted infections that include the offer

of HIV testing to those age 13 and older; screening for substance abuse and mental health; screening for physical/sexual abuse; and discussion of the male role in pregnancy prevention, including condom use and abstinence.

The clinicians also agreed that during longer visits and with time permitting, they should assess the teen’s relationship with peers, partners and parents, and discuss transition into adulthood, sexual identity, sexual orientation and relevant risk factors. Gay, bisexual and transgender teens have a well-established risk for depression, substance abuse and suicide, researchers say.

Clinicians in the study failed to agree on a list of core services to be delivered during nonroutine visits, even though puberty— the time when most teens have their first and formative sexual experiences—is also a time marked by increasingly fewer routine visits to the doctor.

“It is critical that we, as clinicians, find ways to reach these patients outside of routine visits and devise ways to deliver some of these services even when they come to us for specific illness or problems unrelated to sexual health,” Marcell says.

The researchers say they hope that their findings will be a catalyst for policymak-

ers and adolescent-health experts to draft and issue national guidelines and recommendations. The researchers say that medical school and residency training programs should expand their curricula on teen males’ sexual and reproductive health to better prepare the next generation of pediatricians to care for these patients.

“Our study indicates that clinicians who specialize in male teen health agree on the services they deem essential for their patients,” Marcell says. “What we need now is a set of uniform guidelines to help all pediatricians do the same.”

One encouraging finding, the authors say, was that services deemed important by clinicians to a large extent mirrored the recommendations issued in the Pediatrics article.

Additional services listed in the Pediatrics piece include making hepatitis A and B, and HPV vaccinations, part of the annual exam and urging parents to engage their sons in age-appropriate discussions of sexuality and health.

Jonathan Ellen, of the Johns Hopkins Children’s Center, is co-author on the research study.

Co-authors on the Pediatrics article are Charles Wibbelsman, of Kaiser Permanente in California; and Warren Seigel, of SUNYHealth Center at Brooklyn.

Patterns of malaria drug resistance show human, mosquito contrast

By Tim Parsons

Bloomberg School of Public Health

A

study conducted by researchers at the Johns Hopkins Malaria Research Institute and their Zambian colleagues detected contrasting patterns of drug resistance in malaria-causing parasites taken from both humans and mosquitoes in rural Zambia.

Parasites found in human blood samples showed a high prevalence for pyrimethamine resistance, which was consistent with the class of drugs widely used to treat malaria in the region. However, parasites taken from mosquitoes had very low prevalence of pyrimethamine resistance and a high prevalence of cycloguanil-resistant mutants, indicating resistance to a newer class of antimalaria drug not widely used in Zambia.

The findings were published Nov. 7 in the online edition of the journal PNAS and

were discussed at a seminar, “The Forever War: Malaria vs. the World,” held Nov. 16 in New York by the Johns Hopkins Bloomberg School of Public Health and the New York Academy of Sciences.

Surveillance for drug-resistant parasites in human blood is a major effort in malaria control. Malaria in humans is caused by the parasite Plasmodium falciparum, which is spread from person to person through the feeding of the Anopheles mosquito. Over time, through repeated exposure to medications, the parasites can become less susceptible to drugs used to treat malaria infection, limiting their effectiveness.

“This contrast in resistance factors was a big surprise to us,” said Peter Agre, an author of the study and director of the Johns Hopkins Malaria Institute. “The contrast raises many questions, but we suspect that the malaria parasite can bear highly hostspecific drug-resistant polymorphisms, most likely reflecting very different selection pref-

erences between humans and mosquitoes.”

For the study, Sungano Mharakurwa, lead author and a senior research associate in Macha, Zambia, with the Johns Hopkins Malaria Research Institute, compared DNA analyses of P. falciparum found in human blood samples and in mosquitoes collected inside homes in rural Zambia. In samples taken from human blood, pyrimethamineresistant mutations were greater than 90 percent and between 30 and 80 percent for other polymorphisms. Mutations of cycloguanil resistance were 13 percent.

For parasites found in the mosquito midgut, cycloguanil-resistant mutants were at 90 percent, while pyrimethamine-resistant mutants were detected between 2 and 12 percent.

“Our study indicates that mosquitoes exert an independent selection on drugresistant parasites, a finding that has not previously been noticed,” Mharakurwa said.

“If confirmed in other malaria endemic

regions, it suggests an explanation for why drug resistance may appear so rapidly.”

Worldwide, malaria afflicts more than 225 million people. Each year, the disease kills approximately 800,000, many of whom are children living in Africa.

Authors of the study, in addition to Mharakurwa and Agre, are Taida Kumwenda, Mtawa A. P. Mkulama, Mulenga Musapa, Sandra Chishimba, Clive J. Shiff, David J. Sullivan, Philip E. Thuma and Kun Liu. Funding was provided by the Johns Hopkins Malaria Research Institute, the Bill & Melinda Gates Foundation and the National Institutes of Health.

The Johns Hopkins Malaria Research Institute, a state-of-the-art facility at the Johns Hopkins Bloomberg School of Public Health, focuses on a broad program of basic science research to treat and control malaria, develop a vaccine and find new drug targets to prevent and cure the deadly disease.

Trauma patients more likely to die at hospitals serving minorities Patients’ lack of insurance likely impacting quality of care, mortality, study finds B y S t e pha n i e D e s m o n

Johns Hopkins Medicine

S

eriously injured patients cared for at hospitals serving larger numbers of minorities are significantly more likely to die than those treated at hospitals serving mostly whites, regardless of the race of the patient, new Johns Hopkins research suggests.

The racial makeup of the general patient population in a trauma care facility may be a major factor contributing to the welldocumented problem of racial disparities in treatment outcomes experienced by trauma patients in the United States, the researchers argue in the September issue of Archives of Surgery.

Study leader Adil H. Haider, an assistant professor of surgery at the Johns Hopkins University School of Medicine, says that the root cause could be financial. The lowperforming hospitals—those with a higher

death rate among trauma victims—generally serve a higher proportion of uninsured and low-income patients, meaning the facilities may have less money to devote to patient care.

“This study shows us that we need to strengthen the resources of hospitals that serve large numbers of minority and uninsured patients,” said Haider, a trauma surgeon. “The higher the number of uninsured patients, the less able the hospital may be to improve care and outcomes.”

Haider and his team examined records from 311,568 adult trauma patients treated for serious injuries at 434 U.S. hospitals in 2007 and 2008.

The researchers placed hospitals into one of three categories: those in which the percentage of minority patients is more than 50 percent, those in which the percentage of white patients is more than 50 percent and those in which 25 to 50 percent of patients are minorities.

More than 50 percent of the hospitals were predominantly white, more than a quarter were mixed, and 13 percent were classified as predominantly minority.

Trauma patients at mixed hospitals were 16 percent more likely to die than those at mostly white hospitals, and patients at

predominantly minority hospitals were 37 percent more likely to die, the researchers found. In analyzing only patients with blunt injuries, such as those from a car crash, patients at predominantly minority hospitals were even more likely to die (45 percent).

Insurance status also differed at these hospitals. Trauma patients treated at the predominantly white hospitals were nearly twice as likely to have insurance as those taken to predominantly minority hospitals.

People without insurance tend to visit doctors less often and may arrive at the hospital with more pre-existing health problems that complicate their serious traumas, problems that could impact recovery, Haider says.

“Lack of insurance is generally regarded as more than just the inability to pay a bill,” added Haider, who is also co-director of the Johns Hopkins Center for Surgery Trials and Outcomes Research. Hospitals that treat more minorities and more uninsured often have issues such as staffing shortages, constrained budgets and lack of capital and technical support, he says.

Another important finding of the new study, Haider notes, is that minority patients did not have worse outcomes at predominantly white hospitals. He says this suggests

that a large proportion of racial disparities observed after trauma may be due to worse outcomes seen at predominantly minority hospitals.

“The heavy concentration of minority patients at a relatively small number of hospitals presents a unique opportunity for interventions that could achieve an immediate and substantial impact in mitigating disparities,” Haider said. “If we focus on hospitals that predominantly serve minority populations, we may be able to get an excellent bang for our buck.”

This study was supported by grants from the National Institutes of Health, the American College of Surgeons and the Johns Hopkins Center for Health Disparities Solutions.

Other Johns Hopkins researchers working on this study are David T. Efron, Valerie K. Scott, Elliott R. Haut, Eric B. Schneider and Lisa A. Cooper.

Related website Adil Haider:

www.hopkinsmedicine.org/surgery/ faculty/Haider

December 12, 2011 • THE GAZETTE

9

Landmark DNA study finds easier way to diagnose pancreatic cysts B y V a n e s s a W a s ta

Johns Hopkins Medicine

S

cientists at Johns Hopkins have surveyed the DNA in four common types of pancreatic cysts and have determined that each type bears a distinct pattern of gene mutations. Pancreatic cysts are present in about 2 percent of U.S. adults and can, in some cases, require surgical removal and microscopic analysis to determine their type and likelihood of turning cancerous.

“The findings should let us identify most pancreatic cysts accurately without major surgery, sparing patients unnecessary and hazardous procedures—and enabling those with dangerous cysts to have them removed long before they turn into pancreatic tumors,” said Bert Vogelstein, the Clayton Professor of Oncology at the Johns Hopkins Kimmel Cancer Center and co-director of Johns Hopkins’ Ludwig Center for cancer biology research.

Reporting Dec. 5 in the online early edition of the Proceedings of the National Academy of Sciences, the Johns Hopkins scientists also discovered clues to the cysts’ possible origins: a new tumor suppressor gene and disruptions to the ubiquitin protein-disposal system.

Kenneth W. Kinzler, professor of oncology at the Johns Hopkins Kimmel Cancer Center and co-director of the Ludwig Center, said, “Our results should help physicians manage the increasingly large number of patients with pancreatic cysts, and should help biologists understand how such cysts develop and turn cancerous.”

Pancreatic cysts are relatively common after middle age; most are not worrisome and, until recently, people who had such cysts seldom knew that they were there.

However, the increasing use of MRI, CT

Genetic Continued from page 1 are considered rare, afflicting fewer than 200,000 people each. So-called Mendelian disorders are caused by a change in a single gene and are inherited in a manner first observed in the 19th century by Gregor Mendel, an Austrian monk. Many of the 5,000 known Mendelian disorders, such as cystic fibrosis and muscular dystrophy, are well-known, but many more are so rare that they affect only a few dozen families.

Johns Hopkins manages and curates OMIM, the Online Mendelian Inheritance of Man, an encyclopedia of known genetic conditions; how they manifest; and the genes, if known, that contribute to them.

OMIM currently contains 3,000 unexplained Mendelian conditions.

Previously, the challenges to identifying the single genetic cause included the need to assemble many large families, which is timeconsuming, labor-intensive, costly and difficult because of the rarity of individual disorders. “But now, due to what we’ve learned from the Human Genome Project, the rapid evolution of sequencing technology and the power of genetics, we’re at an exciting time where we can solve many of these diseases in just a few months, using samples from a small number of affected individuals and their families,” Valle said. “This new grant enables us to assemble the team and perform the studies needed to accomplish this task.”

The three centers will collaborate with a worldwide network of rare-disease experts to gather samples from thousands of people with these conditions and sequence their genomes to identify the genetic variants responsible for the disorders. To collect new patient samples, the Johns Hopkins–Baylor group hopes to capitalize on its global network of former trainees to identify patients and families with unknown inherited conditions and send DNA samples for sequencing.

Valle says that they are interested in families

and ultrasound scans of the abdomen means that these cysts are often found incidentally, posing a dilemma for doctors and patients.

“We would like to know which cysts are dangerous, but the clinical diagnosis of pancreatic cysts can be wrong unless the cyst is directly examined after being removed surgically,” said Ralph Hruban, professor of pathology and oncology and director of the Sol Goldman Pancreatic Cancer Research Center at the Johns Hopkins University School of Medicine, who designed the study in conjunction with Vogelstein. “Moreover,” he said, “such surgery can have complications, sometimes disturbing digestive and other pancreas-dependent functions, so we really need to find a way to diagnose these cysts without operating.”

One way would be to harvest fluid and cells from cysts during an ultrasound endoscopy of the pancreas—a relatively inexpensive and safe outpatient procedure—and check the DNA in the sample for mutations that are characteristic of the cyst type.

Vogelstein and Kinzler have helped pioneer the study of gene mutations that underlie cancer and, with Hruban, recently began applying this molecular pathology approach to pancreatic cysts. In a study reported in Science Translational Medicine in July, their research teams surveyed 169 cancer-related genes in the most common type of pancreatic cyst, intraductal papillary mucinous neoplasms, or IPMNs, and found that two genes were frequently mutated in these cysts.

In the new study, the team went further by surveying all the protein-coding regions of DNA in eight sample IPMNs as well as eight samples of the three other common pancreatic cyst types: serous cystadenomas, or SCAs; mucinous cystic neoplasms, MCNs; and solid pseudo-papillary neoplasms, SPNs. Each turned out to have its own pat-

afflicted with recognizable conditions for which the culprit gene is unknown, families afflicted with conditions for which genes are known for some small population of patients but are not altered in these families, and families afflicted with inherited conditions that thus far remain undiagnosed.

“We expect that the knowledge about genetic variants that underlie Mendelian disorders will facilitate rapid and accurate diagnosis and might lead to new therapeutic approaches,” said Lu Wang, National Human Genome Research Institute program director for the Mendelian Disorders Genome Centers Program. “This knowledge can also shed light on more common, complex diseases that involve similar genes, pathways and phenotypes, and contribute to the understanding of basic human genetics.”

To jump-start these projects, the centers already have solicited thousands of samples from researchers studying several hundred rare disorders. The centers will continue to solicit samples and maintain a public list of available materials. The University of Washington will serve as the coordinating center for the program. The centers plan to join the International Rare Disease Research Consortium, whose goal is to develop diagnoses of most rare diseases and treatments for about 200 disorders by 2020.

“In addition to solving Mendelian disorders, we hope to learn more about the general principles of disease and understand disease mechanisms at a much deeper level,” Valle said. “We’re excited about what this can teach us and how we hope to use this information to improve the outcomes for patients and families with these rare disorders.” G

tern of DNA abnormalities that was readily distinguishable from the others. The SCAs typically showed signs of a missing fragment of chromosome 3, disrupting the activity of the known tumor-suppressor gene VHL. The MCNs commonly had mutations in the growth-driving oncogene KRAS, as well as mutations in or losses of the gene RFN43, newly identified here as a tumor suppressor.

Surprisingly, Vogelstein says, SPNs bore hardly any mutations, except in the gene CTNNB1, which hints at an unusual mechanism of cancer development, since most tumors appear to arise only after multiple mutations. The IPMNs, as in the previous study, commonly had mutations to the oncogenes KRAS and GNAS, but this wider survey revealed that they typically (six out of eight samples) bore RFN43 mutations, too.

“Looking at the mutation patterns in these five genes and perhaps a few others should allow physicians to do a much better job of diagnosing and managing these cysts,” Hruban said.

The study has implications for basic cancer research as well, Kinzler notes. It identifies RFN43 as a tumor suppressor for the first time, and scientists may pursue whether RFN43 plays a role in other cancers. The study also points to the disruption of the ubiquitin system in cells as a key factor in the development of cysts. Three of the genes whose loss or mutation appears to underlie the development of pancreatic cysts—VHL, CTNNB1 and RFN43—are known to interact with the ubiquitin protein-disposal system, which helps remove abnormal proteins and helps keep normal proteins at healthy levels. VHL and RFN43 code for proteins that act as ubiquitin ligases, which means that they mark unwanted proteins for disposal by tagging them with ubiquitin molecules.

Disruptions of ligase activity could mean that the proteins they normally tag with ubiquitin are allowed to rise to unsafe levels.

Similarly, the CTNNB1 mutations found in SPN cysts are known to make the gene’s product, the protein beta-catenin, resistant to normal disposal by ubiquitin-tagging. Disruptions to the ubiquitin system that leave the levels of key proteins unregulated have been implicated before in cancers, but they now seem particularly important in pancreatic cysts. “It’s an intriguing finding that will certainly stimulate further research,” Vogelstein said.

Major support for the study was provided by the Lustgarten Foundation, a private nonprofit dedicated to funding pancreatic cancer research. Other funding was provided by the Virginia and D.K. Ludwig Fund for Cancer Research, the Sol Goldman Pancreatic Cancer Research Center, the Joseph L. Rabinowitz Fund, the Michael Rolfe Foundation, the Stringer Foundation, the family of Ted and Julie Smith, the Indiana Genomics Initiative of Indiana University, which is supported in part by Lilly Endowment Inc., The J.C. Monastra Foundation, Swim Across America and grants from the National Science Foundation, the National Institutes of Health and the National Cancer Institute.

In addition to Vogelstein, Kinzler and Hruban, the authors of the report are Jian Wu, Yuchen Jiao, Marco Dal Molin, Anirban Maitra, Roeland F. deWilde, Laura D. Wood, James R. Eshleman, Michael Goggins, Christopher L. Wolfgang, Marcia L. Canto, Richard D. Schulick, Barish H. Edil, Michael A. Choti, Alison P. Klein, Hannah Carter, Rachel Karchin, Luis A. Diaz Jr. and Nickolas Papadopoulos, all of Johns Hopkins; Volkan Adsay, of Emory University; David S. Klimstra and Peter J. Allen, both of Memorial Sloan-Kettering Cancer Center; G. Johan A. Offerhaus, of University Medical Center of Utrecht in the Netherlands; Levy Kopelovich, of the National Cancer Institute; C. Max Schmidt, of Indiana University; and Yoshiki Naito, of Kurume University School of Medicine in Japan.

Printing Services Finds Beauty in the Details On the Homewood campus is an incredible university resource with the capacity for customized high-volume copy work, short-run printing and everything in between.

Where Printing Services really shines, though, is in its attention to detail. Just ask. Its professionals know printing and duplicating, but even better, they know Johns Hopkins University and how important your work is.

Make Printing Services—a part of Marketing & Creative Services— your destination for copying and printing solutions.

To find out how Printing Services can help you with your next project, visit web.jhu.edu/printingservices or contact Ann Grattan at aeg@jhu.edu.

Printing Services Working for the Johns Hopkins community

Related website McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins:

www.hopkinsmedicine.org/ geneticmedicine MCSads.indd 5

11/11/11 1:19 PM

10 2011 10 THE THE GAZETTE GAZETTE •• December August 15,12, 2011 H U M A N

R E S O U R C E S

B U L L E T I N

Notices

Hot Jobs

Funding for Musculoskeletal Research Projects — The Johns Hopkins Center for

Listed below are some of the university’s newest openings for indemand jobs that we most urgently need to fill.

In addition to considering these opportunities, candidates are invited to search a complete listing of openings and apply for positions online at jobs.jhu.edu.

Homewood Office of Human Resources Wyman Park Building, Suite W600 410-516-7196 Critical postings within our Homewood Division include the following immediate opportunities. For detailed job descriptions and to apply, go to jobs.jhu.edu.

48307 48770 50367 50493

Senior Development Director for Asia Librarian for East Asian Studies, Anthropology and Political Science Annual Giving Data Specialist, Annual Fund Office HR Generalist, External Affairs and Development

Musculoskeletal Research announces the availability of funding for pilot and feasibility projects.

The CMR funds are available to encourage innovative research in pathogenic mechanisms, basic science and therapeutic approaches related to muscle and bone research.

Three grants of $30,000 (direct costs

Limited decision-making ability of individual cells is bolstered in masses Johns Hopkins Medicine

R

Office of Human Resources 98 N. Broadway, Suite 300 410-955-2990 The offices of Billing & Quality Assurance and Clinical Research Billing & Quality Assurance are seeking qualified applicants to provide professional fee-compliance services, including ongoing training and support to physicians, nonphysician providers, professional fee billing staff, clinic staff, administrators, principal investigators and clinical research coordinators. For a detailed job description and to apply, go to jobs .jhu.edu.

49455 49609 50793

Compliance Specialist Trainer Compliance Specialist Trainer Compliance Specialist Trainer

Schools of Public Health and Nursing Office of Human Resources 2021 E. Monument St. 410-955-3006 The Bloomberg School of Public Health is seeking skilled applicants for part- and fulltime positions. For detailed job descriptions and to apply, go to jobs.jhu.edu.

45746 Biostatistician 48603 Senior Biostatistician 48892 Research Program Manager 49767 Programmer Analyst 49814 Academic Program Manager 50426 Administrative Coordinator 50466 Student Affairs Officer 50514 Project Administrator 50525 Nurse Practitioner/Physician Assistant Johns Hopkins University is an equal opportunity employer and does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, other legally protected characteristics or any other occupationally irrelevant criteria.

Woodcliffe Manor Apartments

S PA C I O U S

G A R D E N A PA RT M E N T L I V I N G I N

R O L A N D PA R K

• Large airy rooms • Hardwood Floors • Private balcony or terrace • Beautiful garden setting • Private parking available • University Parkway at West 39th St. 2 & 3 bedroom apartments located in a private park setting. Adjacent to Johns Hopkins University Homewood Campus and minutes from downtown Baltimore.

410-243-1216

105 West 39th St. • Baltimore, MD 21210 Managed by The Broadview at Roland Park BroadviewApartments.com

only) for a one-year pilot will be awarded, with eligibility to apply for a one-year competitive renewal.

Junior investigators without current or past NIH research support, or established investigators who would like to transition to a new career focus, are encouraged to apply.

The deadline for submission of the letter of intent for the 2012 grants is Jan. 4.

Contact Lynne Jones at 443-444-5906 or by email to ljones3@jhmi.edu with any questions about the program. For more information, go to www.hopkinsmedicine.org/ musculoskeletal_research.

Researchers discover why many cells are better than one

By Vanessa McMains

School of Medicine

B O A R D

esearchers from Johns Hopkins have quantified the number of possible decisions that an individual cell can make after receiving a cue from its environment and, surprisingly, it’s only two.

The first-of-its-kind study combines livecell experiments and math to convert the inner workings of the cell decision-making process into a universal mathematical language, allowing information processing in cells to be compared with the computing power of machines.

The research published Sept. 15 in Science also demonstrates why it’s advantageous for cells to cooperate to overcome their meager individual decision-making abilities by forming multicellular organisms.

“Each cell interprets a signal from the environment in a different way, but if many cells join together, forming a common response, the result can eliminate the differences in the signal interpretation while emphasizing the common response features,” said Andre Levchenko, an associate professor of biomedical engineering and a member of the Institute for Cell Engineering at Johns Hopkins. “If a single blood vessel cell gets a signal to contract, it is meaningless since all the surrounding cells in the blood vessel need to get the message to narrow the blood vessel. Cell collaboration does wonders in terms of [the cells’] ability to transfer information and convert it into decision making.”

One bit of information represents two choices: yes or no; on or off; or one or zero in binary code, used by computer programmers.

Two bits doubles the number of choices to four and so on for each bit added.

To determine how many bits of information a cell has for each decision, the researchers had to measure a real biological decision in progress. They decided to look at a well-known cell stimulant, a protein called tumor necrosis factor, or TNF, which is responsible for turning on the inflammation response in the body. When cells detect TNF on their surface, they transmit a message that sends a messenger protein into the nucleus to turn on inflammation genes.

The researchers administered different amounts of TNF to mouse cells in dishes, and then they determined whether the messenger went to the nucleus. They bound the messenger with a glowing tag; the more messenger present in the nucleus, the brighter the nucleus would appear under a microscope. The researchers used a computer program to quantify the brightness of the nucleus after the addition of TNF. From this, they calculated a single cell’s response to be 0.92 bits of information, allowing for two possible decisions.

“What we get from this information is that the cell can only reliably detect the presence of the signal or not, nothing more

precise,” Levchenko said. “This was a little bit dissatisfying because we were hoping that the cells could recognize many more levels of the input and use that to make more decisions than just two.”

The researchers tested other scenarios to see if cells could respond in more ways.

They looked at decision outputs other than inflammation, such as development and cell survival. They also looked to see if the cell’s response to a certain stimulus changed over time, as well as explored whether receiving different input signals that led to the same outcome could boost decision-making potential. None of these different situations drove cells to show greater decision-making ability. Cells seem to have distinct limits to the amount of information they intake, which confines the number of decisions they can make, Levchenko said.

Finally, the researchers investigated the idea that cells could collectively respond to input to make decisions together. They went back to quantifying the brightness of the nucleus in response to TNF, but this time they examined clusters of cells and compiled this data into their equation. They found that clusters of as few as 14 cells could produce 1.8 bits of information, corresponding to somewhere from three to four different potential decisions for the cluster.

The fact that combinations of cells can make more decisions suggests why being multicellular is such a good thing in the animal world and why cells can sometimes achieve so much more if they are working together than separately, Levchenko said.

“We’ve learned that there is a clear limit on what can happen in a cell, and we are actually quantifying for the first time what the cells can and can’t do,” Levchenko said.

“A lot of people were surprised that this was even possible. This framework we’ve laid will allow us to test what kind of tricks cells use, other than being multicellular, to expand their decision repertoire.”

The first author on the study, Raymond Cheong, was responsible for much of the experimental and theoretical analysis.

Other researchers involved, in addition to Levchenko, were Alex Rhee and Chiaochun Joanne Wang, both of Johns Hopkins; and Ilya Nemenman, of Emory University.

The study was supported by the National Institutes of Health, the Medical Scientist Training Program at Johns Hopkins and the Los Alamos National Laboratory Directed Research and Development Program.

Related websites Andre Levchenko’s lab:

jshare.johnshopkins.edu/alevche1/ web

Department of Biomedical Engineering:

www.bme.jhu.edu/index.php

Institute for Cell Engineering:

www.hopkinsmedicine.org/ institute_cell_engineering/index .html

December 12, 2011 • THE GAZETTE

Classifieds APARTMENTS/HOUSES FOR RENT

Ashland/Hunt Valley/Cockeysville, 4BR, 3.5BA TH, AC, front loader W/D, 2 fps, hot tub, fenced patio w/storage, walk to NCR trail, avail Jan 1. $1,975/mo. 410790-6903.

M A R K E T P L A C E

affordable. $149,900. 443-851-6514 or panfile@gmail.com.

Fells Point (300 blk S Durham St), 3 stories, new front and rear masonry work, nice yd, 3 blks to JHH. $175,000. Dorothy, 410-4193902.

Bolton Hill, 1BR apt sublet, free prkng and laundry, 15-min walk to Penn Station, nr light rail/metro. $800/mo incl heat, water, Internet. qhgb253@gmail.com.

Lutherville, 5BR, 2.5BA single-family splitlevel, on 0.42 acre lot, 2,498 sq ft, fp, hdwd flrs, orig owner, great public school district, nice neighborhood, good for kids, conv location. Tony, 410-804-3653.

Brewers Hill, rehabbed 2BR, 2.5BA TH, gourmet kitchen, fin’d bsmt, no pets, avail Feb 1. $1,850/mo. 410-303-1214 or hudsonstreetrental@hotmail.com.

Manhattan-style efficiency condo in owneroccupied, elegant and secure bldg, steps from Homewood campus. $98,500. 443414-6282.

Butchers Hill/Upper Fells Point, 1BR, 1BA apt, 2 flrs, kitchen, new W/D, bsmt storage, lg backyd, walk to school. $895/mo + utils.

Sharon, 443-695-9073.

Naples, FL, 2BR, 2BA condo in private 55+ community w/clubhouse and swimming pool, 26-ft dock, no bridges to Gulf, heated pool. $249,000. sticks@maine.edu.

Canton, 2BR, 2BA waterfront condo, W/D, 2 garage prkng spaces, avail Feb 2012, pics avail. $3,000/mo + utils. cpruva@yahoo .com.

Washington Hill, 3BR, 2BA condo w/ contemporary layout, walk to JHH/shuttle, move-in ready. $130,000. 717-739-8233.

Deep Creek Lake/Wisp, cozy 2BR cabin w/ full kitchen, call for wkly/wknd rentals. 410638-9417 or jzpics@yahoo.com (for pics).

Ellicott City, spacious 3BR, 2.5BA TH on corner, new windows, kitchen/dining area, fin’d walkout bsmt, deck/patio, Centennial high school zone. $1,875/mo. 410-979-9065 or rashmachaudhry@yahoo.com.

Gardenville, lg studio bsmt apt, open flr plan, W/D on same level, nr JHH/JHU/ Bayview. $675/mo + utils + sec dep. 410426-8045 or rent5214anthony@verizon.net (for pics).

Homeland, renov’d 2BR, 2BA in quiet bldg, new kitchen, dw, gas stove, CAC, W/D and storage in bsmt, balcony w/stream view, nr Belvedere shops, gated community has pool and exercise rm. $1,225/mo incl heat. 410243-0007 or tinyurl.com/c46vd4q (for pics).

Homeland, 1BR, 1BA duplex on 26-acre estate, living rm, dining rm, kitchen, hdwd flrs, W/D, dw, prkng, pref mature prof’l. $975/mo incl utils. abbottja@hotmail.com.

Lutherville-Timonium, quiet, beautiful 3BR, 3BA house, hdwd flrs, well-designed kitchen, living rm, bsmt and family rm, garage, no pets/no smokers, 15-20 mins to Homewood or JHMI, avail Feb 1. $1,850/mo + utils. Sheng, 443-690-1483 or sheng.w.wu@ gmail.com.

Pikesville, recently renov’d 4BR, 1BA house, hdwd flrs, deck, porch, fenced yd, walking distance to subway. $1,200/mo.

410-370-2822 or lenabe52@gmail.com.

Roland Park, lg 1BR apt + dining rm, avail Dec 15. $1,100/mo incl heat, garage space, storage unit. mikesuse@comcast.net.

2907 St Paul St, newly renov’d 1BR apt, 1st flr, hdwd flrs, new cabinets, safe and quiet neighborhood. $900/mo incl heat, water. murilo_silvia@hotmail.com.

HOUSES FOR SALE

Catonsville, fully renov’d 3BR, 2BA RH, hdwd flrs throughout, new windows, new kitchen, new W/D, move-in ready and

I-83/Timonium exit, 4BR, single-family house, 5 fin’d levels, remodeled BAs, fp in living rm, new roof/windows, hdwd flrs. $399,000. Val, 443-994-8938 or yankybrit@ hotmail.com.

ROOMMATES WANTED

F nonsmoker wanted to share 2BR apt (218 N Charles St) in downtown Baltimore, conv to bus stops, 1BR, 1BA avail. $765/mo incl heat, water (elec and Internet separately assessed, usually less than $50). 703-9664295.

Nonsmoker wanted for furn’d 700 sq ft BR in 3BR house in Cedonia owned by young F prof’l, bright, modern kitchen w/convection oven, walk-in closet, landscaped yd, lg deck, free prkng, public transportation to JHU, wireless Internet incl’d. $550/mo + utils.

410-493-2435 or aprede1@yahoo.com.

Washington Hill, nonsmoker bedspacer in contemporary condo, adjacent to Church Professional Bldg (98 N Broadway), walk to JHH/shuttle. $450/mo + utils. retzcare@ yahoo.com.

Share apt on W University Pkwy, across from Homewood Field, beginning spring 2012, name a reasonable price. amaechipa@ hotmail.com.

Share all new refurbished TH w/medical students, 4BRs, 2 full BAs, CAC, W/D, dw, w/w crpt, 1-min walk to JHMI, 924 N Broadway. gretrieval@aol.com.

Rm in updated single house in nice, safe Towson area, free prkng, 2-min walk to MTA #3, 19 and 55, 20-min drive to Homewood campus or JHMI. $580/mo + utils. wjfj@hotmail.com.

F nonsmoker wanted for 1BR in 2BR W University Pkwy apt, share w/Hopkins alumna, AC, heat, hot water, 5 mins to campus, no pets, start January. $540/mo + 1/2 elec. gwxts5@gmail.com.

Share Charles Village apt w/JHU grad student, hdwd flrs, living rm, CAC/heat, your rm has a desk and chair, 2 lg windows and a patio, nr #3 bus stop, nr BMA/sculpture garden/Homewood campus, would like

HICKORY HEIGHTS WYMAN COURT Just Renovated! A lovely hilltop setting Beech Ave. adj. to JHU!

Studios - $595 - $630 1 BD Apts. - $710-740 2 BD from $795

on Hickory Avenue in Hampden!

To purchase boxed display ad space in The Gazette, contact

2 BD units from $760 w/Balcony - $790!

The Gazelle Group

Shown by appointment 410.764.7776 www.BrooksManagementCompany.com

11

gazellegrp@comcast.net

someone to stay 6 mos. $430/mo + sec dep (1 month’s rent). 646-344-0831.

table w/chairs, dresser, misc housewares. wallrat@gmail.com.

Rm avail in Hampden, share house w/33-yrold F, shared BA, W/D, hdwd flrs, pref nonsmoker, move in Feb 1 (flexible), 10-min walk to JHU. $600/mo + utils. angiemelliott@ gmail.com.

Apple iBooks (several), G3 or G4, 12" to 14", wireless, OSX 10.4, in very good shape. $120 and up (negotiable). hopkinsbob@ yahoo.com (for pics/details).

SERVICES/ITEMS OFFERED OR WANTED

CARS FOR SALE

’89 Chevy Silverado pickup, 4x4, rebuilt motor, new tires. $2,000. John, 443-7507750. ’05 Lexus SC430, black w/off-white leather interior, Navi, CD/cassette, garage-kept, clean, well maintained w/all records, 90K mi. $21,000/best offer. Monica, 410-3714318. ’07 VW Passat, black, leather, DVD, Navi, CD, MP3, clean, up-to-date on maintenance, 115K mi (highway). $9,500. 804504-1202 or louis.alexjr@gmail.com.

Transmission repairs, rebuilt or used, 20% discount for all JHU faculty, staff, students and employees, free estimate, 8am-10pm.

Bob, 410-574-8820.

Mt Washington family needs nurturing, enthusiastic, creative, active person to care for 2-mo-old daughter, starting January when mother returns to work, pref experience w/infants, nonsmoker, OK w/pets, own transportation a must. hvahvet@gmail.com.

Schedule fun at your holiday parties w/ intuitive psychic Catori and astrologer/tarot card reader Eliza. Eliza, 410-967-3112.

Classical guitarist will play at your event or holiday party; plays other types of music also. 443-801-7592.

ITEMS FOR SALE

Conn alto saxophone, in excel cond. 410488-1886.

La-Z-Boy sofa and loveseat set, very comfortable, in very good cond, cushions incl’d, treated w/stain-resistant spray when new. $250. ar_thakar@yahoo.com.

Free jewelry: look at quality jewelry, receive percentage of sales, invite friends from home or office. 646-441-1534.

Friday Night Swing Dance Club, open to public, great bands, no partners necessary.

410-663-0010 or www.fridaynightswing.com.

Single ticket for Center Stage’s production of GLEAM, based on Zora Neale Hurston’s Their Eyes Were Watching God, 8pm on Fri, Jan 13, row K, seat 19. $40. Lori, 410-9177774 or niccole532@comcast.net.

Tutor for all subjects/levels; remedial and gifted; help w/college counseling, speech and essay writing, editing, proofreading.

410-337-9877 (after 8pm) or i1__@hotmail .com.

Sand beach chairs (2), inkjet printer, oilfilled heaters (3) and baseboard heaters (2), portable canvas chair, keyboard case, 100W amplifier. 410-455-5858 or iricse.its@ verizon.net.

Searching for donations of video and computer games and Nintendo DS machines for pediatric psychiatric unit. Nurse Annie, 716-430-2768.

Motorcycle gear: Women’s leather jacket, lined, XS, $125; women’s Milwaukee boots, #7, $85; 12-volt battery charger, $45; all in excel cond. lisamwolf@comcast.net.

Classical guitar, 1977 Calidad Suprema by Jose Oribe, beautifully crafted, warm sound, good projection, in excel cond, incls orig case. $7,500/best offer. 443-621-5650.

Bassett pecan wood dining rm table w/pad, leaf and 6 chairs, $200; Bassett pecan wood hutch, 2 glass doors, 3 cabinets on bottom, $200; both in good cond, best offers accepted. 443-417-3817 or vainmd23@aol.com.

Bookcases (5), coffee tables (2), kitchen

Holiday auto detailing, email your requests. rquinlan2010@hotmail.com.

Piano lessons by Peabody graduate student, reasonable rates. 425-890-1327.

Hauling/junk removal, next-day service, free phone estimate, 15% discount for all Hopkins. John, 443-682-4875.

Licensed landscaper avail for trash hauling, fall/winter leaf or snow removal. Taylor Landscaping LLC. 410-812-6090 or romilacapers@comcast.net.

Need help writing letters? Experienced writer will write/edit all types of letters to your specifications. emceea@gmail.com.

PLACING CLASSIFIED ADS Classified listings are a free service for current, full-time Hopkins faculty, staff and students only. Ads should adhere to these general guidelines: • One ad per person per week. A new request must be submitted for each issue.

• Ads are limited to 20 words, including phone, fax and e-mail.

• We cannot use Johns Hopkins business phone numbers or

e-mail addresses.

• Submissions will be condensed at the editor’s discretion.

• Deadline is at noon Monday, one week prior to the edition in which the ad is to be run.

• Real estate listings may be offered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.)

Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attachments) to gazads@jhu.edu; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Baltimore, MD 21231. To purchase a boxed display ad, contact the Gazelle Group at 410-343-3362.

Live Near Your Work The Live Near Your Work program provides Johns Hopkins employees with the opportunity to receive combined cash grants from the university, Baltimore City and the state of Maryland to be used for the purchase of homes within selected local neighborhoods.

Grants are available to full-time, benefits-eligible employees of Johns Hopkins University, Johns Hopkins Hospital, Johns Hopkins Health Care, Johns Hopkins Community Physicians, Johns Hopkins Bayview and Johns Hopkins Home Care Group. Other restrictions may apply.

To find out more, contact the Office of Work, Life and Engagement at 443-9977000 or go to web.jhu.edu/lnyw/index.html.

12 THE GAZETTE • December 12, 2011 D E C .

1 2

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Calendar COLLOQUIA Wed., Dec. 14, 3:30 p.m. “Signatures of Supermassive Black Hole Coalescence,” an STSci colloquium with Tamara Bogdanovic, University of Maryland.

Bahcall Auditorium, Muller Bldg.

“Zonula Occludens (ZO)-1 and -2 Regulate Cytoskeletal Organization, Morphology and Migration in Polarized Epithelia,” a Cell Biology seminar with Alan Fanning, University of North Carolina, Chapel Hill. Suite 2-200, 1830 Bldg. EB

“New Methods and Results—Old Problem: AraC,” a Biology colloquium with Robert Schleif, KSAS. Mudd Hall Auditorium. HW

Wed., Dec. 14, 4:30 p.m.

DISCUSSION/ TALKS Freeman Hrabowski III, president of UMBC, gives a keynote address titled ‘Expanding Underrepresented Minority Participation: America’s Science and Technology Talent at the Crossroads.’ See Special Events.

MUSIC

Peabody Chamber Winds performs works by Glass, Schoenberg and others. Friedberg Hall. Peabody

Tues., Dec. 13, 7:30 p.m.

The Preparatory Wind Orchestra and Wind Band perform. Griswold Hall.

Sat., Dec. 17, 3 p.m.

Peabody

F I L M / V I D EO Wed.,

Dec.

14,

6:30

p.m.

Screening of the documentary Age of Delirium: The Decline and Fall of the Soviet Union, based on the book by SAIS visiting scholar David Satter. Sponsored by the Foreign Policy Institute at SAIS and the Hudson Institute. To RSVP, go to http://hudson.org/ index.cfm?fuseaction=hudson_ upcoming_events&ID=902.

Kenney Auditorium, Nitze Bldg.

SAIS

G RA N D ROU N D S

“The Role of Unstructured Information and Bayesian Inference in the Health Care Delivery System,” Health Sciences Informatics grand rounds with Alan Stein, Autonomy Inc. W1214 SPH. EB

REA D I N G S / B OO K T A L K S Fri., Dec. 16, 7 p.m. Poetry reading by contributors to the Loch Raven Review, including Dan Cuddy, Chris George, Dave Eberhardt, Danuta Kosk-Kosicka and Constantine Pantazonis. Barnes & Noble Johns Hopkins. HW Sat., Dec. 17, 11 a.m. to 1 p.m.

Local photographer Roger Miller will sign copies of his latest collection, Annapolis—Sailing Capital of Maryland, and other Baltimore- and Maryland-related works. Barnes & Noble Johns Hopkins. HW

Fri., Dec. 16, 12:15 p.m.

I N FOR M A T I O N SESSIONS

Information session, via conference call, on the Carey Business School’s “global immersion” course to be offered in the spring. (See In Brief, p. 2). To join the conference call, go to https://connect.johnshopkins .edu/turkey-global-immersion.

The call number is 410-955-4009; the access code is 246800.

L E C T URE S Thurs.,

Dec.

15,

S E M I N AR S Mon., Dec. 12, noon. “Parental Monitoring and Problem Behaviors,” a Mental Health thesis defense seminar with Ines Bustamante. 845 Hampton House. EB

“The Thermococcus kodakarensis DNA Replication Machinery,” a Biochemistry and Molecular Biology seminar with Zvi Kelman, NIST. W1020 SPH. EB

Mon.,

Mon., Dec. 12, noon.

Mon.,

p.m.

“Renal Cell Carcinoma/Antiangiogenic Rx,” a Sidney Kimmel Comprehensive Cancer Center visiting professor lecture by Brian Rini, Case Western Reserve University. Owens Auditorium. EB

Dec.

Dec.

12,

12,

noon.

12:15

p.m.

“Developmental and Regenerative Biology of Cardiac Progenitor Cells,” a Carnegie Institution Embryology seminar with Sean Wu, Harvard Stem Cell Institute.

Rose Auditorium, 3520 San Martin Drive. HW Mon.,

4:30

Wed., Dec. 14, 4 p.m. “Responses to the Credibility Crisis in Computational Science: Accountability and Public Health,” a Biostatistics seminar with Victoria Stodden, Columbia University.

W2030 SPH. EB Thurs., Dec. 15, noon.

HW

Wed., Dec. 14, 2 p.m. “Incomplete Security Sector Reform in Serbia: Lessons for Democratic Transition,” a SAIS Center for Transatlantic Relations panel discussion with Jelena Milic, director, Center for Euro-Atlantic Studies in Serbia; Daniel Serwer, SAIS; and Vedran Dzihic (moderator), SAIS. Co-sponsored by the National Endowment for Democracy. To RSVP, go to www.eventbrite .com/event/2622329458/mcivte.

500 Bernstein-Offit Bldg. SAIS

seminar with Zhihao Zhuang, University of Delaware. West Lecture Hall (ground floor), WBSB. EB

Dec.

12,

12:15

p.m.

“Supporting Child Mental Health in Humanitarian Settings: Current Knowledge and Future Directions,” a Mental Health faculty candidate seminar with Wietse Tol, Yale University. B14B Hampton House. EB

Mon., Dec. 12, 1 p.m. “The Cell’s Compass: Chemoattractants Bias Excitable Networks to Direct Cell Migration,” an Immunology Training Program seminar with Peter Devreotes, SoM. Tilghman Auditorium, Turner Concourse. EB Mon.,

Dec.

12,

1:30

p.m.

“Imaging Voltage: From E. coli to Neurons,” a Biomedical Engineering seminar with Joel Kralj, Harvard University. 709 Traylor.

EB (Videoconferenced to 110 Clark. HW )

Thurs., Dec. 15, noon. “Understanding the Molecular Regulation of Lymphocytes Using a Human Genetic Approach,” a Molecular Microbiology and Immunology/ Infectious Diseases seminar with Michael Lenardo, NIAID/NIH. W1020 SPH. EB

“Mechanisms of mGluR5 Dysfunction in Fragile X Syndrome,” a Neuroscience research seminar with Kimberly Huber, Southwestern Medical Center. West Lecture Hall (ground floor), WBSB. EB

Thurs., Dec. 15, 1 p.m.

Mon., Dec. 12, 2 p.m. “A New and Unexpected DomainDomain Interaction in the AraC Protein,” a Biology thesis defense seminar with Stephanie Cole.

100 Mudd. HW Mon.,

Fri., Dec. 16, 10 a.m.

Dec.

12,

3:30

p.m.

Tues., Dec. 13, 12:15 p.m.

“Toward a Revised Case Classification for Dengue Virus Infections—Evidence From a Multicenter Study,” an International Health seminar with Thomas Jaenisch, Heidelberg University Hospital, Germany. W2030 SPH. EB Wed., Dec. 14, 12:15 p.m.

Mental Health Noon Seminar— “What’s Anthropology Have to Contribute to Interventions in Mental Health?” with Britt Dahlberg, University of Pennsylvania.

B14B Hampton House. EB “Husbands’ and Wives’ Fertility Intentions and Fertility Behavior in Minya, Egypt,” a Population, Family and Reproductive Health thesis defense seminar with Adel Takruri. E4611 SPH. EB

Wed., Dec. 14, 1 p.m.

Wed., Dec. 14, 4 p.m. “Chemistry and Biology of Eukaryotic Translesion Synthesis,” a Pharmacology and Molecular Sciences

•

“Etiology and Pathogenesis of Aortic Aneurysm Syndromes,” an Institute of Genetic Medicine/Human Genetics Graduate Program thesis defense seminar with Kathleen Kent. 590 Rangos Bldg. EB

Fri., Dec. 16, noon. “Role of Testosterone in Coxsackievirus B3 Myocarditis and Dilated Cardiomyopathy,” an Environmental Health Sciences thesis defense seminar with Michael Coronado.

W7023 SPH. EB

“How and Where Transposons Go,” a Carnegie Institution Embryology seminar with Nancy Craig, SoM. Rose Auditorium, 3520 San Martin Drive. HW

Mon., Dec. 19, 12:15 p.m.

SPECIAL EVENTS

Thurs., Dec. 15, daylong. Professional Development Day for KSAS/WSE Graduate Students and Postdoctoral Fellows. Sponsored by the Krieger and Whiting Graduate Affairs and Admissions Office and MINDS (Mentoring to Inspire Diversity in Science). Registration is required; go to http:// professionaldevelopment2011 .eventbrite.com. HW

•

9 to 9:45 a.m. Keynote address on the recent National Academies report “Expanding

10 to 10:45 a.m.

Tracks—

Career

“Non-Academic Career Tracks” with Daniel Denecke and Julia Kent, Council of Graduate Schools. 213 Hodson.

“Science and Engineering Academic Paths” with Judith Mitrani-Reiser, WSE. 110 Maryland.

“Humanities and Social Sciences Academic Paths” with Angus Burgin and Ron Walters, both of KSAS. 311 Hodson.

Funding—

•

11 a.m. to noon.

“Funding in the Sciences and Engineering” with Gregory Ball, KSAS, and Joe Katz, WSE. 110 Maryland.

Thurs., Dec. 15, 12:15 p.m.

“SHINE: Multidisciplinary Approach Toward Identifying the Causes and Solutions to Child Stunting Anemia,” a Human Nutrition seminar with Jean Humphrey, SPH. Sponsored by the George G. Graham Endowment.

W2008 SPH. EB

Fri., Dec. 16, 9 a.m. “The Epidemiology of Hepatitis E Virus and the Relationship Between Infection in Pigs and Humans in a Community of AgriculturalFood System in Nan Province, Thailand,” an Epidemiology thesis defense seminar with Soawapak Hinjoy. W2030 SPH. EB

“Combining Clinical Observation With Public Health Training to Design a Health Disparity Intervention: The CAPABLE Project,” a Hopkins Center for Disparities Solutions seminar with Sarah Szanton, SoN. Sponsored

by Health Policy and Management. B14B Hampton House. EB

Underrepresented Minority Participation: America’s Science and Technology Talent at the Crossroads,” by Freeman Hrabow­ski III, president of UMBC. (See photo, this page.) Hodson Hall Auditorium.

“Funding in the Social Sciences and Humanities” with Christine O’Brien, National Academies, and Wilsonia Cherry, National Endowment for the Humanities.

205 Krieger.

•

12:15 to 1:45 p.m. “Different Professional Environments,” a lunchtime panel discussion with Marc Roy, provost, Goucher College; Bryant Nelson, National Institute of Standards and Technology; Daniel Denecke and Julia Kent, Council of Graduate Schools; Akim Reinhardt, Towson University; and Erin Fitzgerald, Department of Defense.

Great Room, Levering.

•

2 to 2:45 p.m.

“Sciences and Engineering: Startups” with Raymond Cheong, SoM. B17 Hackerman.

“Humanities and Social Sciences: Book Publication” with William Egginton and Anand Pandian of KSAS, and Robert Brugger, JHU Press. 311 Hodson.

•

“Finishing the PhD,” with Barbara Baum, Homewood Student Affairs; Melissa Libertus, KSAS; and Dan Pierce, School of Education. B17 Hackerman.

3 to 3:45 p.m.

(Events are free and Calendar

open to the public Key

except where indicated.)

APL BRB CRB CSEB

Applied Physics Laboratory Broadway Research Building Cancer Research Building Computational Science and

Engineering Building EB East Baltimore HW Homewood JHOC Johns Hopkins Outpatient Center KSAS Krieger School of Arts

and Sciences NEB New Engineering Building PCTB Preclinical Teaching Building SAIS School of Advanced

International Studies SoM School of Medicine SoN School of Nursing SPH School of Public Health WBSB Wood Basic Science Building WSE Whiting School of Engineering