If April showers bring May flowers, we are sure to have a beautiful Spring here in the South Dakota region! We are kicking things off with this colorful issue of MED, the region's premier source for medical community news, features and events. In this month's cover article, we discuss the evolution of IORT for breast cancer with two members of Avera's breast care team. Our thanks to breast surgeon Julie Reiland, MD, and to radiation oncologist Kyle Arneson, MD, for the illuminating conversation. This issue also features articles on technology, research, outreach, education, and an advanced procedure that led to a dramatic outcome.