[Gattefossé]
YOUR RELIABLE SUPPLIER FOR DRUG DEVELOPMENT As a leading provider of functional lipid excipients and formulation solutions to healthcare industries worldwide, Gattefossé is committed to delivering high-quality excipients, technical support and inspiring formulations for drug delivery.
Oral drug delivery Lipid excipients for oral drug delivery include solubility and bioavailability enhancers, lubricants, modified release, taste-masking, API protection and suspending agents. Excipients are used in a variety of processes enabling the formulation of different dosage forms, mainly tablets, granules, hard and soft capsules. Many active pharmaceutical ingredients have poor water solubility and/or poor permeability, which affect their bioavailability. Lipidbased formulations are widely used to overcome these issues and can be developed in using a stepwise approach, which is described in Gattefossé’s brochure. Gelucire 44/14 and Labrasol ALF are self-emulsifying excipients that can be used as single excipient to increase drug solubility, permeability and/or bioavailability of drugs. Multiple excipient combinations using oils (e.g. Maisine CC, Peceol), surfactants (e.g. Gelucire, Labrafil) and solvents (e.g. Transcutol HP) form self-emulsifying lipid-based formulations. Click on the link for more information: https://bit.ly/3wJtlmQ. Tablets and capsules are the most preferred dosage forms. However, a lubricant
is required to reduce the friction between particles and equipment when manufacturing tablets and capsules. Compritol 888 ATO is a lubricant of choice for challenging pharmaceutical tablets when used at 1% to 3%. Its inertness eliminates drug-excipient incompatibility issues. As mixing time and speed do not affect its efficiency or tablet hardness, it offers flexibility in formulation development and production. It is the ‘trouble-shooting’ lubricant for tabletting. Click on the link for more information: https://bit.ly/3fXyce8. Many APIs have an unpleasant taste or odour which need to be masked to facilitate their absorption. Coating the drug particle with a lipid film is a common practice to positively change the drug organoleptic properties. Precirol ATO 5 can be used in a high shear or fluid bed coating process and enables the formation of a film coating WWW.PHARMACOS.CO.ZA // FORMULATION DESIGN
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