Biotechnology & Biomedical Engineering 2011

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Biotechnology & Biomedical Engineering 2011

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Dear Colleague, We are delighted to present our new and forthcoming titles in the field of micro- and nanoscale science, technology and medicine.

As an independent international publisher, we publish a range of quality books in various topical areas ranging from monographs to review volumes and textbooks with a single aim in mind: inspiring innovation.

We believe that our titles would be a valuable addition to your professional library and enhance your research and educational needs.

What Our Readers and Authors Say “What an elegant library covering an exceptionally broad range of nanoscience topics! I shall be most happy to show it to colleagues in the field and share with them. Congratulations on your enterprise.”

Prof. John Polanyi (Nobel Laureate) University of Toronto, Canada

Key New Titles • Handbook of Materials for Nanomedicine, by V. Torchilin & M. Amiji • Handbook of Nanoindentation, by M. L. Oyen • Molecular Diagnostics, by J. T. Jørgensen & H. Winther Popular Titles • Who Cloned My Cat?, by R. Renneberg • Dendrimer-Based Nanomedicine, by J. R. Baker & I. Majoros • Nanotherapeutics, by A. Lamprecht Book Series • Pan Stanford Series on Biomedical Nanotechnology • Pan Stanford Series on Nanoscale Raman Spectroscopy • Pan Stanford Series on Nanobiotechnology

“I am very pleased with the performance of the publisher and staff in the writing of my book and would not hesitate to recommend them to my friends and colleagues.”

Prof. Howard Green Harvard Medical School, USA

If you have any queries about sales, marketing, editorial or any other issues, please let me know by sending an email at jenny@panstanford.com. You can also visit our website at www.panstanford.com.

Sincerely,

Jenny Rompas Director and Publisher Pan Stanford Publishing Pte. Ltd.

About Pan Stanford

Pan Stanford Publishing is an independent international publisher of science, technology and medicine. The company was founded by a group of publishing professionals who are devoted to meet the needs of the scholarly and professional communities worldwide.

Driven by passion and a clear mission, we strive to serve the needs of academics and of professional communities worldwide in three ways: by collaborating closely with researchers and professionals of outstanding achievement, by fostering long-term partnerships with our readers and distributors and by developing the most accurate publications that can inspire and further promote innovation and discovery.

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“This was my first experience in editing a book and it turned out to be a very fruitful one. I was greatly assisted in all the steps, from the initial planning to the final publication of the book. All the staff involved in the production of the book were so nice and helpful, that the work was much easier even for a beginner like me. I am very much satisfied with the final result, which summarizes the work of several fantastic collaborators and colleagues in the field of genomics.”

Dr. Piero Carninci RIKEN, Japan

“The editorial process is very smooth and the cover design is great! The manuscript style files are very helpful and the instructions are easy to follow for the contributors. It was a great pleasure to work with Pan Stanford Publishing.”

Prof. Alf Lamprecht University of Franche-Comté, France

“My experience with Pan Stanford was very good and there is no way for the publisher to improve their process that I can think of now. I am very pleased with the end product of this long bookwriting process. Pan Stanford has been very helpful to me and published a fine book.”

Prof. Istvan Majoros University of Michigan, USA

Biotechnology and Biomedical Engineering 2011

Handbook of Nanoindentation with Biological Applications

edited by Michelle L. Oyen (University of Cambridge, UK) “The book spans a wide variety of topics ranging from the fundamental theory and instrumentation of nanoindentation to its application in biological materials, including soft tissues, mineralized tissues, and cell structures. This book is an excellent resource!”

Prof. Lisa Pruitt University of California, Berkeley, USA “The contributing authors summarize the latest developments in a very useful and readable way.”

Prof. Alfonso H. W. Ngan University of Hong Kong, HK “Michelle Oyen has brought together an impressive group of experts who are able to explain the theoretical and experimental background and to provide a wealth of data and examples. From now on there will be no excuse!”

Prof. David Taylor Trinity College Dublin, Ireland Nanoindentation is ideal for the characterization of inhomogeneous biological materials. However, the use of nanoindentation techniques in biological systems is associated with some distinctively different techniques and challenges. For example, engineering materials used in the microelectronics industry (e.g. ceramics and metals) for which the technique was developed, are relatively stiff and exhibit time-independent mechanical responses.

Biological materials, on the other hand, exhibit time-dependent behavior, and can span a range of stiffness regimes from moduli of Pa to GPa — eight to nine orders of magnitude. As such, there are differences in the selection of instrumentation, tip geometry, and data analysis in comparison with the “black box” nanoindentation techniques as sold by commercial manufacturers. The use of scanning probe equipment (atomic force miscroscopy) is also common for small-scale indentation of soft materials in biology.

Readership: Graduates, postgraduates and researchers.

Hardback • 400pp • Sep 2010 978-981-4241-89-2 • US$149.00

Handbook of Intelligent Scaffold for Tissue Engineering and Regenerative Medicine edited by Gilson Khang (Chonbuk National University, Korea)

• Discusses the great potential of scaffold applications ranging from novel biomaterials to novel fabrication methods and the targeted organ.

• Comprises chapters written with the student and industry professionals in mind.

• Maintains a good balance of clinical, commercial and experimental chapters.

It has been recognized that tissue engineering and regenerative medicine offers an alternative technique to whole-organ and tissue transplantation for diseased, failed or malfunctioned organs. To reconstruct a new tissue by tissue engineering and regenerative medicine, triad components, such as (1) cells that are harvested and dissociated from the donor tissue, (2) scaffold substrates as biomaterials in which cells are attached and cultured so as to result in the implantation at the desired site of the functioning tissue and (3) growth factors that promote or prevent cell adhesion, proliferation, migration and differentiation by up-regulating or down-regulating the synthesis of protein, growth factors and receptors, are needed.

This book concentrates on intelligent scaffolds, associated biomaterials and manufacturing in terms of tissue engineering and regenerative medicine, from basic principles to the most recent discoveries. The areas of focus include ceramic and metal scaffold, intelligent hydrogel, electrospinning nanofiber, novel biomaterials for scaffold, novel fabrication methods for scaffold and scaffolds for the target organ. The book comprises theoretical, experimental, preclinical and clinical analyses of various properties of biomaterials, research methods, preparation techniques and some promising applications.

Readership: Researchers in medicine, stem cell, regenerative medicine, tissue engineering, drug delivery system and biomaterials science.

Hardback • 500pp (approx.) • Nov 2010 978-981-4267-85-4 • US$249.00

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Handbook of Materials for Nanomedicine

edited by Vladimir Torchilin & Mansoor Amiji (Northeastern University, USA) “A very comprehensive collection of well-written chapters on nanoparticle technologies used for medical applications of all kinds. It is subdivided into organic and inorganic materials nanostructures which is very intelligent way to organize the handbook. It includes the latest information on scaffolds for regenerative medicine that involve nanostructures of many different designs. All in all, it will be a very valuable reference book for the biomaterials scientist and medical researcher involved in many different facets of therapeutics, diagnostics and imaging for medical applications.”

Prof. Allan S. Hoffman University of Washington, USA The fast-developing field of nanomedicine uses a broad variety of materials to serve as delivery systems for drugs, genes, and diagnostic agents. This book is the first attempt to put under one cover all major available information about these materials, including both those that are still on experimental levels and those already applied in patients.

Contents: Organic Nanostructures: Polymeric Nanostructures: Synthetic Polymer-Drug Conjugates for Human Therapy (K. Ulbrich & V. Zubr); Dendrimer-Based Nanomaterials (K. Nam et al.); Combinatorial Polymer and Lipidoid Libraries for Nanomedicine (J.J. Green et al.); Lipid-Based and Other Organic Structures: Liposomal Nanomedicines (V. Torchilin); Nanomedicines from Polymeric Amphiphiles (I.F. Uchegbu et al.); Materials for Nanoemulsions and Their Influence on the Biofate (E. Rozentur et al.); Inorganic Nanostructures: Metal Structures: Biomedical Applications of Multifunctional Silica-Based Gold Nanoshells (L.R. Bickford et al.); Metal Oxide Nanoarchitectures for Biotemplating Application (K.C. Popat & T.A. Desai); and many other papers.

This book is Volume 1 of the Pan Stanford Series on Biomedical Nanotechnology.

Readership: Scientist of all levels from both academia and industry working in the areas of nanomedicine.

Hardback • 840pp (approx.) • Sep 2010 978-981-4267-55-7 • US$399.00

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Therapy with Cultured Cells

Molecular Diagnostics

“This book contains a personal account of the development of therapy with cultured cells by the founder of the field. He describes the first application which he developed for the treatment of burn patients. This methodology was then applied by others to the treatment of eye diseases and the restoration of vision after chemical burns.

Later, other cultured cell types, such as cartilage cells, were introduced for human therapy. These applications are all current in many parts of the world. A must read for all cell biology students!”

Prof. Tung-Tien Sun New York University Medical School, USA

edited by Jan T. Jørgensen & Henrik Winther (Dako Denmark A/S, Denmark)

by Howard Green (Harvard Medical School, USA)

In this book the author describes the discoveries in his laboratory that led to therapy with cultured cells. The first cultured cell type used for therapy was the keratinocyte of the epidermis, for the treatment of burns. Subsequent developments led to the use of cultured cells for the treatment of diseases of the eye, of the joints and of other diseases. Cultured cells for therapy are now being prepared by industries in the US, Japan and Korea and are used in the aforesaid countries, as well as in France, Sweden and Greece, for the treatment of disease.

The Key Driver in Personalized Cancer Medicine

“Not only will academic departments and cancer centers find this book to be an authoritative reference volume, but also the pharmaceutical and biotechnology industries will be able to gain considerable insight that could play a major role in the shaping of their current and future products.”

Prof. Jeffrey S. Ross Albany Medical College, USA “The topics and information covered in the book are the ones highly demanded in the current clinical biomarker sciences. This is definitely one of the references that everyone in this area should have.”

Prof. Jae K. Lee University of Virginia, USA

Cap-Analysis Gene Expression (CAGE) The Science of Decoding Genes Transcription

edited by Piero Carninci (RIKEN, Japan) “This is a comprehensive introduction to a powerful and important new technique that is transforming our understanding of gene regulation. This volume contains everything you need to know to become an expert in CAGE, from library construction to bioinformatic analysis of the voluminous data sets.”

Prof. Gene E. Robinson University of Illinois, USA Novel technologies have recently appeared that allow the deciphering of transcriptional network, based on the identification of the starting site of gene transcription, with the simultaneous measurement of expression level and identification of the promoter elements. These tagging technologies (including cap-analysis gene expression [CAGE] and others) are further boosted from the development of the novel generation of sequencing instruments, which allow transcriptional profiling by sequencing at the cost of microarray experiments.

In addition to keratinocytes, therapeutic use has been made of many cultured cell types, such as ocular limbal cells, chondrocytes and melanocytes.

In addition to these cell types, which must be autologous, use has also been made of allogeneic keratinocytes to promote healing.

This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine.

The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.

The Early History of Cell Culture; The Beginnings of Keratinocyte Cultivation; The Treatment of Burns; Defining the Stem Cell Character of Keratinocytes; Treatment with Allogeneic Cultured Keratinocytes; Treatment of Ocular Disease; Gene Therapy; Therapy with Cultured Chondrocytes; The Promise of Therapy with Embryonic Stem Cells.

The book is the first of its kind to cover relevant subjects around molecular cancer diagnostics when used as important drivers in personalized cancer medicine. The different chapters are authored by key opinion leaders, each representing their specialized areas, so that the reader can gain expertise in the field.

This book is a guide for users of new technologies, as it includes accurately proven protocols, allowing readers to prepare their samples for experiments.

Additionally, it is a guide for the bioinformatics tools that are available for the analysis of the obtained tags, including the design of the software, the sources and the Web. Finally, the book provides examples of the application of these technologies to identify promoters, annotate genomes, identify new RNAs and reconstruct models of transcriptional control. Although examples mainly concern mammalians, the discussion expands to other groups of eukaryotes, where these approaches are complementing genome sequencing.

Readership: Oncologists, pathologists, academic cancer researchers and scientists and others working in the drug and diagnostics industries.

Readership: Biologists from both academia and industry interested in new approaches to address their biological problems.

Hardback • 364pp • Apr 2010 978-981-4241-44-1 • US$159.00

Hardback • 266pp • Oct 2009 978-981-4241-34-2 • US$155.00

Readership: Academics, physicians, scientists, surgeons and biologists.

Paperback • 88pp • Mar 2010 978-981-4267-70-0 • US$79.00

Biotechnology and Biomedical Engineering 2011

MicroRNA Profiling in Cancer A Bioinformatics Perspective

edited by Yuriy Gusev (University of Oklahoma Health Sciences Center, USA) “Yuriy Gusev has wisely put together a fine book linking various aspects of the study of microRNAs starting with profiling of microRNoma, the functional study of pathway networks involving miRNAs as well as evolutionary models of microRNoma evolution or mathematical models of posttranscriptional regulation of microRNAs. Readers will find the book different compared with others already published. One thing is certain: the curiosity of the readers will increase with every page turned.”

Prof. George A. Calin MD Anderson Cancer Center University of Illinois, USA The recent discovery of microRNAs — a new class of non-coding RNAs — has revolutionized modern biomedical sciences. This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology and mathematical modeling.

This volume contains adaptations and critical reviews of the recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation are also discussed.

Readership: A broad audience of academic, biotech and pharmaceutical industry biomedical scientists, physicians involved in cancer research, oncologists, computational biologists and bioinformaticians.

Hardback • 272pp • Oct 2009 978-981-4267-01-4 • US$129.00

Functional Proteomics and Nanotechnology-Based Microarrays

Nanomaterials for Chemical Sensors and Biotechnology

“Functional Proteomics and Nanotechnology provides valuable insight into a new dimension of concepts and approaches that will enhance capabilities to establish signatures of gene expression for biological control and pathologies.”

Prof. Gary Stein University of Massachussetts, USA

“This book offers an excellent insight into the science and technology of nanostructured oxide gas sensors. Unique perspectives and new challenges of hybrid nanomaterials are also provided in the context of a variety of potential applications including biosensors and medicines. Scientists, engineers and students who are engaged in prospective chemical sensors could make the best use of this book as a thought-provoking reference.”

Prof. Makoto Egashira Nagasaki University, Japan

edited by Joshua LaBaer (Harvard Medical School, USA) & Claudio Nicolini (University of Genoa, Italy)

This volume introduces in a coherent and comprehensive fashion the Stanford Series on Nanobiotechnology by defining and reviewing the major sectors of Nanobiotechnology and Nanobiosciences with respect to the most recent developments.

Nanobiotechnology indeed appears capable of yielding a scientific and industrial revolution along the routes correctly foreseen by the numerous programs on nanotechnology launched over the last decade by numerous councils and governments worldwide, beginning in the late 1995 by the Science and Technology Council in Italy and by President Clinton in the USA and ending this year with President Putin in the Russian Federation.

The aims and scope of the series and of this volume are to cover the basic principles and main applications of nanobiotechnology as an emerging field at the frontiers of biotechnology and nanotechnology. A scientific committee formed by Wolfgang Knoll (Max Planck Institute Mainz), Joshua LaBaer (Harvard University, Boston), Michael Kirpichnikov (Moscow University) and Christian Riekel (ESRF, Grenoble) has been established by the publisher to act as an editorial board to discuss with Claudio Nicolini as series editor for the purpose of sourcing and peer-reviewing manuscripts and providing advice on the series of future high-quality volumes.

by Pelagia-Irene Gouma (State University of New York at Stony Brook, USA)

“This book presents a snapsot of the evolution by focusing on oxides and their applications to chemical sensing, biosensing and tissue engineering. It is written based on the author’s expertise and her own research in this area. It is a good reference for students and researchers entering this growing area that will surely produce many innovations and unravel new challenges.”

Prof. Sheikh A. Akbar Ohio State University, USA

This book is Volume 2 of the Pan Stanford Series on Nanobiotechnology.

This textbook is intended to serve as a reference guide to the interdisciplinary fields of nanomaterials, sensors and biotechnology. It demonstrates functional applications of nanotechnology in diverse areas such as environmental sensing and space habitation, medical diagnostics and tissue regeneration. With a focus on novel materials synthesis, such as using the nanomanufacturing technique of electrospinning to get the longest nanowires possible, a correlation is made of the effect of chemical, structural and morphological features to achieve extreme materials functionality. This publication will serve as a manual to nanotechnology for both novices and experts alike, from the materials scientist to the biophysicist and bioengineer and the medical scientist.

Readership: Researchers and students in nanobiotechnology and nanobiosciences fields.

Readership: Researchers and students dealing with nanomaterials and biotechnology.

Hardback • 350pp • Jun 2010 978-981-4267-76-2 • US$159.00

Hardback • 180pp • Oct 2009 978-981-4267-11-3 • US$129.00

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Nanocomposite Particles for BioApplications Synthesis, Properties and Applications

edited by Tito Trindade & Ana Luisa da Silva (Universidade de Aveiro, Portugal) • One of the few examples of a book approaching the bio-applications of nanocomposite particles.

• Includes contributions from specialists with international published research in their field of expertise.

• Illustrated with excellent figures and containing a very good survey of references to accompany each chapter.

This book provides a concise state of the art of the synthesis and properties of nanocomposite particles with a focus on their diverse bio-applications. Contributions are mainly related to the chemical design of nanocomposite particles, their properties as well as their constituent materials and to the tailoring of bio-interfaces that might be relevant for the fields of clinical diagnosis and drug delivery procedures, among others bioapplications. Examples of materials described in the book include particles composed of a polymer matrix containing dispersed inorganic nanophases and other bio-functionalized nanomaterials, along with comments about their practical applications and limitations.

Readership: Researchers, postgraduate and advanced undergraduate students of chemistry, biochemistry, materials science, biotechnology, nanoscience and nanotechnology.

Hardback • 400pp (approx.) • Oct 2010 978-981-4267-78-6 • US$149.00

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Biomaterials for MEMS

edited by Mu Chiao (University of British Columbia, Canada) & Jung-Chih Chiao (University of Texas, USA) This book serves as a guide for practicing engineers, researchers and students interested in MEMS devices that use biomaterials and biomedical applications. It is also suitable for engineers and researchers interested in MEMS and its applications but who do not have the necessary background in biomaterials.

This book highlights important features and issues of biomaterials that have been used in MEMS and biomedical areas. Hence this book is an essential guide for MEMS engineers or researchers who are trained in engineering institutes that do not provide the background or knowledge in biomaterials. The topics include fabrication of devices using biomaterials; biocompatible coatings and issues; thin-film biomaterials and MEMS for tissue engineering; and applications involving MEMS and biomaterials.

Contents: Introduction on Biomaterials for MEMS (M. Chiao & J-C. Chiao); Fabrication/ Materials: Micromachining of Polymeric Materials (M. Chiao); Polymers and Surface Coatings (J. Kizhakkedathu); Laser Deposition of Biomaterials (D. Chrisey et al.); Devices and Applications: Biomaterials of MEMS Devices for Use in the Human Body (Y. Haga & M. Esashi); Biodegradable Elastomers for Tissue Regeneration (J. Yang et al.); Neuroregeneration (R. Bellamkonda & Y-T Kim); Biocompatible Flexible Microelectrodes (K. Cheung); Micelles and Polymer MEMS Microvalves (B. Stoeber); Biocompatibility: Vibration Based Anti-Biofouling of Implants (J. Yeh et al.); Biomaterials for MEMS Drug Delivery (G. Voskerician et al.); Characterization of Biomaterials (H. Zeng) Readership: For engineers and researchers interested in MEMS and its applications but who do not have a background in biomaterials.

Relevant societies include ASME, IEEE and SPIE. Hardback • 400pp (approx.) • Sep 2010 978-981-4241-46-5 • US$149.00

The Microflow Cytometer

edited by Frances Ligler & Jason S. Kim (Naval Research Lab, USA) “An excellent compilation. From history of the very early days of flow cytometers to the latest unique unconventional microflow cytometers.

From commercialization philosophy to cuttingedge engineering designs. From fluid mechanics to optics to electronic circuit considerations. Well balanced and comprehensive.”

Prof. Shuichi Takayama University of Michigan, USA

“The field of microfluidic flow cytometry is developing at a fast rate. New microdevices are being developed that are cheap, easy to use and tailored to specific applications. This book brings together a compilation of the state of the art in the field. The authors offer an in-depth insight into technology issues and future perspectives. An excellent reference for scientists and technologists developing these microsystems and for all interested in the future of microflow cytometry.”

Prof. Hywel Morgan University of Southampton, UK This book will describe the continuing development of inexpensive, portable flow cytometers through incorporation of microfluidic technologies and small optical components. The underlying microfluidic theories essential for microflow cytometry will be discussed in detail, as well as advances that are representative of the current state-of-the-art. Design and fabrication strategies for these innovative component technologies will be subsequently presented by numerous research groups leading the field.

Integration of the components into functional prototype devices for analysis and manipulation of particles and cells will be reviewed. Multiple currently available commercial systems will be examined to highlight both strengths and areas for improvement.

Readership: Scientists, engineers, and corporate strategists interested in developing portable flow cytometers.

Hardback • 396pp • May 2010 978-981-4267-41-0 • US$169.00

Biotechnology and Biomedical Engineering 2011

Who Cloned My Cat?

Fun Adventures in Biotechnology

by Reinhard Renneberg (Hong Kong University of Science and Technology, Hong Kong) “Renneberg’s newest book “Who Cloned My Cat?” is a personal journey through the science and politics of biotechnology. The reader is presented with sixty-eight two-page chapters, ranging from current attempts to limit the cyanide poisoning of fish to the effect of the cold war on sugar prices.

Following in the tradition of Lewis Thomas and Stephen J. Gould, Renneberg has created a book perfectly suited for recreational reading, full of scientific wonder and social context.”

Dr. David Goodsell The Scripps Research Institute, USA “In this fascinating short stories, featuring the distinctive cartoons of Manfred Bofinger and Ming Fai Chow, we learn a lot! For example, the spread of bird flu is very likely not be carried out on wild birds, but that there are clear links with poultry shipments there. A compendium of biotechnology in everyday life, therefore, competent in his scientific and historical statements, masterly in execution and in humorous words and pictures.

This makes science fun!”

Günter Kröber “Science is fun!” is the motto of this fun-filled book by Prof. Reinhard Renneberg. Do you know that in Japan, washing machines have no “cooking program” thanks to enzyme detergents? How to make German-style beer from rice? How do you make real snow with dead frost-bacteria? Is using bio-ethanol as a car fuel going against our environment? How can you clone your neighbor’s beautiful cat? How to eliminate breast cancer genes before a baby girl is born? Can the financial crisis be solved by breeding better stock market traders? How to measure the fitness of students?

The questions are endless.

Readership: Interested laypersons wanting to know more about the front-edge subject of biotechnology and to be entertained and amused at the same time, students, lecturers and experts in the sciences, and school teachers and pupils looking for entertaining reading.

Hardback • 250pp (approx.) • Sep 2010 978-981-4267-65-6 • US$24.95

Carbon Nanotubes

From Bench Chemistry to Promising Biomedical Applications

edited by Giorgia Pastorin (National University of Singapore, Singapore) • Includes a simplified description of different topics related to carbon nanotubes and a detailed index for readers, so that young scientists and researchers outside their field of expertise can familiarize themselves with the subject easily.

• Discusses how carbon nanotubes can be physically and chemically manipulated to become suitable tools for cancer therapy, drug delivery, gene expression, etc. To that purpose, many synthetic procedures and images have been included in each chapter.

• Features a special session devoted to the cautious evaluation of potential hazards attributed to carbon nanotubes, in terms of their use as delivery systems and their effects associated with prolonged environmental exposure.

In recent years, there has been an increasing interest in the terms nanotechnology and nanomaterials. Nanotechnology involves applying science through the use of nanomaterials, among which carbon nanotubes represent a fascinating example. In particular, carbon naotubes have garnered growing attention because of their promising applications in several biomedical fields, including cancer and gene therapy, vaccines and tissue engineering.

This book represents a critical evaluation of the most recent discoveries about carbon nanotubes and includes a cautious description of their impact on personal health and environmental pollution.

It also offers an overview of the main research groups around the world which have been focusing their efforts on the exploitation of this intriguing material, with the purpose of inspiring young scientists to follow their pathway.

Readership: Students and researchers in science, especially chemistry, biology, pharmacy and medicine.

Hardback • 350pp (approx.) • Oct 2010 978-981-4241-68-7 • US$129.00

Dendrimer-Based Nanomedicine

edited by Istvan Majoros & James R. Baker Jr. (University of Michigan, USA) “The authors’ approach to fill in a little history with futuristic perspective will be a delight to all readers interested in the field. A must read.”

Prof. George R. Newkome

The University of Akron, USA In recent decades, dendrimers — free-shaped synthetic macromolecules — have garnered a great deal of scientific interest because of their unique molecular nanostructure. Used in a variety of scientific applications, dendrimers are now widely regarded as a safer, more precise and more effective way to practice medicine.

This book compiles and details cuttingedge research in science and medicine from the interdisciplinary team of the Michigan Nanotechnology Institute for Medicine and Biological Sciences, which is currently revolutionizing drug delivery techniques through the development of engineered nanodevices.

Edited by Istvan J. Majoros and James R. Baker Jr, two prominent nanotechnology researchers, this book will appeal to anyone involved in nanotechnology, macromolecular science, cancer therapy or drug delivery research.

Contents: Targeted Drug Delivery in General, New Technology in Medicine (B.B. Ward & J.R. Baker, Jr.); General Carriers for Drug Delivery (T. H. Dunham et al.); Poly(amidoamine) Dendrimer Synthesis and Characterization (I.J. Majoros & D.E. Carter); Optical and Biophotonic Applications of Dendrimer Conjugate (J.Y. Ye & T.B. Norris); Dendrimer Conjugates for Cancer Treatment (I.J. Majoros et al.); Biological Application of PAMAM Dendrimer Nanodevices in vitro and in vivo (T.P. Thomas & J.F. Kukowska-Latallo); and many more.

Readership: Advanced undergraduate- and graduate-level students in nanotechnology as well as researchers in macromolecular science, nanotechnology, chemistry, biology and medicine, especially those with an interest in drug delivery or cancer therapy.

Hardback • 440pp • May 2008 978-981-4241-04-5 • US$215.00

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Life at the Nanoscale

Viral Nanoparticles

by Yves Dufrêne (Université Catholique de Louvain, Belgium)

edited by Nicole Steinmetz & Marianne Manchester (Scripps Research Institute, USA)

Atomic Force Microscopy of Live Cells

• Provides a comprehensive overview of the use of atomic force microscopy and related scanning probe techniques for analyzing cells and membranes, going from the basics to the applications side.

• Features chapters authored by cutting-edge experts.

• Written a bibliography for further reading.

At the crossroads of nanoscience and life sciences, the nanoscale analysis of living cells using atomic force microscopy (AFM)-based techniques is an exciting, rapidly evolving research field. During the past years, there has been tremendous progress in using AFM to observe cells and membranes at high resolution. Remarkable advances have also been made in applying force spectroscopy techniques to study cellular mechanics, to localize single receptors on live cells and to measure cellular interactions. These AFM-based measurements contribute to improving our understanding of the structure-function relationships of cell walls and membranes and have a strong potential in biomedicine, for example, for elucidating the mechanisms of cell–drug and pathogen–host interactions.

This timely book provides a comprehensive overview of the use of AFM and related scanning probe microscopies for cell surface analysis, going from the basics to the applications side.

It will appeal to anyone involved in cell biology, microbiology, biophysics, biochemistry or nanosciences. It is the first of its kind to cover all cell types, from viruses and protoplasts to bacteria and animal cells, and to discuss a range of advanced AFM modalities, including high-resolution imaging, nanoindentation measurements, recognition imaging, singlemolecule and single-cell force spectroscopy.

Readership: Students and researchers in the fields of nanotechnology, biophysics, cell biology, microbiology and biomedicine Hardback • 400pp (approx.) • Nov 2010 978-981-4267-96-0 • US$149.00

Tools for Materials Science and Biomedicine

• Is a comprehensive overview of the manifold applications of VNPs in nanotechnology. The book covers research from scientists from all over the world.

• Explains the technical terminology of nanotechnology, a highly interdisciplinary field that brings together virologists, chemists and materials scientists.

• For young and established researchers working on or interested in viral nanotechnology.

The utilization of viral nanoparticles (VNPs) in nanosciences and nanotechnology has become a popular field of research. From a materials science point of view, VNPs are attractive building blocks for several reasons: the particles are on the nanometer scale, they are monodisperse with a high degree of symmetry and polyvalency, they can be produced with ease and on a large scale, and they are exceptionally stable, robust, biocompatible and bioavailable. VNPs are “programmable” units which can be modified by either genetic modification or chemical bioconjugation methods.

Readership: Undergraduate and graduate students, postdoctoral fellows and established researchers in viral nanotechnology, virology, nanotechnology, materials science and biomedicine.

Hardback • 400pp (approx.) • Oct 2010 978-981-4267-45-8 • US$149.00

Nanoimaging

edited by Beth Goins & Wiliam Phillips (University of Texas Health Science Center at San Antonio, USA) • Is the first book dedicated to imaging nanoparticles in vivo.

• Covers research on a wide variety of nanoparticles for monitoring disease detection and treatment by non-invasive medical imaging.

• Provides examples of the application of nanoparticles for numerous medical imaging modalities, including optical imaging, ultrasound, nuclear medicine and magnetic resonance imaging.

Progress in nanotechnology has resulted in the design and synthesis of many new types of nanoparticles. Concurrently, there has been a rapid explosion in new medical imaging technologies that can non-invasively detect and monitor the targeting of nanoparticles in vivo. As leading experts in the related fields, the editors and individual authors of this book describe upto-date reviews on the application of these new nanoparticles for in vivo medical imaging and drug delivery.

This book covers cutting-edge research on the use of nanoparticles for in vivo diagnostic medical imaging and therapy. A variety of nanoparticles are discussed, including quantum dots, carbon nanotubes, dendrimers, gold nanoshells, metal nanorods, micelles, liposomes, polymers, MRI iron oxide particles and microbubbles. Examples include multifunctional nanoparticles that are designed for multi-modality imaging and simultaneous diagnostic and therapy (theranostic) applications.

This book is Volume 3 of the Pan Stanford Series on Biomedical Nanotechnology.

Readership: Students and researchers in nanosensor development, medical imaging, radiology, nuclear medicine, magnetic resonance imaging, nanotechnology, chemistry, biology and medicine, especially those with an interest in molecular imaging, drug delivery and nanomedicine.

Hardback • 400pp (approx.) • Nov 2010 978-981-4267-09-0 • US$149.00

Biotechnology and Biomedical Engineering 2011

Amyloid Structures in Nature

edited by Susi Jarvis & Anika Mostaert (Trinity College Dublin, Ireland) • Highlights the bredth of functional amyloid found in nature by bringing together the many recent discoveries into a single volume.

• Contains contributions by leading authors across the range of functional amyloid discovered to date.

• Includes an extensive bibliography and indicates anticpated future developments.

Amyloid fibrils are notorious for their association with a group of debilitating and often incurable diseases called the Amyloidoses, which include Alzheimer’s, Parkinson’s and glaucoma amongst others. They have come under increasingly intense scrutiny in recent years due to the devastating effect these particular diseases can reap on aging populations. It is therefore surprising that amyloid fibrils have recently been found to have specific functions in a range of organisms from bacteria to humans. This has forced the scientific community to change the way we consider amyloid, from being a ‘mistake’ caused by the aggregation of ‘misfolded’ proteins, to a structure that can be either physiological or pathogenic in a manner not yet fully understood.

This is the first book to bring together a wide variety of examples of functional amyloid in a single volume. Ten chapters provide coprehensive information on the importance of amyloid fibrils in fungi, bacteria, algae, invertebrate and vertebrate animals, for providing environmental protection, structural integrity and regulating biochemical processes. Due to their functional manifestation amyloid fibrils have huge potential to form the basis of a new generation of proteinaceous biomaterials for a broad range of applications.

Readership: Highly multidisciplinary, including students and researchers in biology, biochemistry, biophysics, botany, zoology, cell biology, molecular biology and materials science. The book can ideally be a textbook for the study of protein structure and function.

Hardback • 250pp (approx.) • May 2011 978-981-4267-40-3 • US$149.00

Biomedical Nanosensors

edited by Joseph Irudayaraj (Purdue University, USA) • Discusses a range of nanomaterials as sensors from the first principles to applications.

• Features contributions from leading authors from different disciplines, thereby providing a multidisciplinary perspective to the compilation.

• Includes an extensive bibliography for further reading.

Biomedical nanosensors play a central role in the development of diagnostics and therapeutics for early detection and treatment of diseases.

Bringing a nanoscale perspective to sensing is expected to allow investigation of biological systems; detection of ultra-small concentration of biomolecules, ions, and molecular interactions; exploration of cellular mechanisms and integration of nanosensors into many other devices, including implantable devices. The book specifically addresses nanomaterials, constituting nanoparticles, nanowires and nanotubes of inorganic as well as polymeric composition of nano- and micro-scale dimensions, as sensing and therapeutic agents since these constitute a major direction in nanomedicine. Selected technologies involving single-molecule and single-particle methods for tracking are also addressed.

This book is Volume 2 of the Pan Stanford Series on Biomedical Nanotechnology.

Hardback • 400pp (approx.) • Dec 2010 978-981-4303-03-3 • US$149.00

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The Functional Fold

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Artificial Human Sensors Science and Applications

by Peter Wide (Örebro University, Sweden) “This book represents a thought-provoking overview of the intriguing field of the machine sensing and perception based on an ever evolving human-instrument partnership. It discusses new intelligent technologies that enhance the natural sensing, perception, and mobility abilities of humans allowing them to have a healthier, more productive, safer and overall better life.”

Prof. Emil Petriu Ottawa University, Canada The importance of creating sophisticated information support to humans is increasing with the society need for supporting elderly population with limited sensing performance. This can be seen as a paradigm for increasing the support to different groups in the population as well as a service concept to the citizens.

This can also be extended from a personal level into a global view, where a group of people can increase their information level e.g. earthquake or tsunami warning systems. The book aims to involve the human related (based) and artificial sensing in coherence with the human perception capabilities (auditory, taste, smell, vision and touch). Also the fusion of these sensing information could be discussed, i.e how do we increase our human “fuzzy” decision capability (perception) e.g. the field of culinary art, the atmosphere in the dining room is also affecting the perception of tasting the food.

Readership: Readerships and students in sensors, electrical and electronics engineering.

Hardback • 400pp (approx.) • Aug 2010 978-981-4241-58-8 • US$149.00

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Synchrotron Radiation and Structural Proteomics

edited by Eugenia Pechkova (University of Genoa, Italy) & Christian Riedel (European Synchrotron Radiation Facility, France) This book gives an overview of the current state of research in both synchrotron radiation and structural proteomics from different laboratories all over the world, while touching upon all possible aspects of frontier research in this area.

The contribution from the advanced research group from different synchrotrons (ESRF, BNL, Spring 8, CHESS) and structural proteomics groups all over the world gives a unique international flavor to the book. Every chapter represents a review article; however, new research results, never published so far, are also presented. The reader can get an insight into the recent progress made in the leading research laboratories of different countries. The most advanced methods of synchrotron radiation analysis, protein microand nanocrystallography, X-ray scattering and X-ray optics, and coherent X-ray diffraction, including laser cutting and contactless sample manipulation, are described in detail. Emphasis is placed on biological applications, and such important aspects as radiation damage and molecular modeling are also highlighted.

This book is Volume 3 of the Pan Stanford Series on Nanobiotechnology.

Readership: Students and researchers in biophysics and bionanotechnology; researchers in macromolecular science, nanotechnology, physics, chemistry, biology and medicine, especially those with an interest in the advanced methods of synchrotron radiation and structural proteomics.

Hardback • 400pp (approx.) • Dec 2010 978-981-4267-38-0 • US$149.00

Molecular Motors in Bionanotechnology

Water

• Features illustrated examples of major groupings of motors.

• Provides a coherent review of groupings and families of molecular motors.

• Includes a discussion of future uses in synthetic biology and bionanotechnology.

• Discusses current knowledge and outstanding questions on the importance of water in living systems.

• Features contributions by leading experts in the field from USA, Europe and Asia.

• Has a good balance of theoretical and experimental chapters.

• Includes an extensive bibliography for further reading.

by Keith Firman & James Youell (University of Portsmouth, UK)

Biological molecular motors provide most cells with the dynamic systems required for their dayto-day existence. The examples that exist occur in even the simplest organism (e.g., a bacterium, a virus), and the range of tasks that they carry out is vast. Over the last few years, there has been a large increase in the study of these motors, and it is becoming apparent that many motors will find uses in either bionanotechnology or synthetic biology.

This book describes a wide range of molecular motors, ranging from chemical motors to biological motors, in a manner that updates, or reviews, both classification of the type of motor and grouping into families. Many techniques have evolved to study and characterise molecular motors at the single-molecule level (e.g., using molecular tweezer devices), and the reader is introduced to the concepts and benefits of each technique. In addition, the book looks at structural information and how this helps understand function and finally at how some of these motors may be used in the future as part of a synthetic biology approach to building devices and sensors.

Readership: Researchers in biology and molecular biology.

Hardback • 400pp (approx.) • Dec 2010 978-981-4267-02-1 • US$149.00

The Forgotten Biological Molecule

edited by Denis Le Bihan (CEA Saclay, France) & Hidenao Fukuyama (Kyoto University, Japan)

The book addresses a number of highly topical aspects of a fast-emerging field and emphasizes some important, but yet unclear, roles of water in biological processes, up to brain function. The main objective of this book is to bring together multidisciplinary contributions from leading authorities on the properties and roles of water in cell systems which are otherwise dispersed in the literature and difficult to gather. The authors are drawn from areas of physics, chemistry, biology and physiology, where water plays a central role.

The book focuses on current research and developments in the theoretical and experimental studies of water in biological systems and compounds, such as interaction with hydrophobic or hydrophilic structures, protein and membrane surfaces. It provides insights into the importance of water in cellular processes and physiology and, ultimately, in life, brain function and health.

Readership: Scientists in academia or industry (water, health), ecologists and medical doctors.

Can be used as a basis for new research and as a textbook for graduate students of different subjects (medicine, biology, physics, chemistry, engineering, etc.).

Hardback • 400pp (approx.) • Dec 2010 978-981-4267-52-6 • US$99.00

Biotechnology and Biomedical Engineering 2011

Handbook of Metal Biotechnology Applications for Environmental Conservation and Sustainability

edited by Satoshi Soda, Michihiko Ike (Osaka University, Japan) & Mitsuo Yamashita (Shibaura Institute of Technology, Japan) • Covers a new discipline, “metal biotechnology”, emphasizing applications for the fields of environment conservation and resource recycling.

• Introduces various fields of metal biotechnology, including (i) wastewater treatment and bioremediation for hazardous metals, (ii) recovery and recycling of metals, (iii) biological synthesis and processing of new metallic materials and (iv) bio-informatics in metal biotechnology.

• Features contributions from various members of Metal-biotechnology Research Division in The Society for Biotechnology, Japan.

Metal elements refined from underground resources remain finite and might suffer depletion, presenting society with a serious problem.

This book introduces various fields of metal biotechnology, emphasizing applications for the fields of environment conservation and resource recycling.

The book proposes the development of “metal biotechnology” to cope appropriately with the above difficulties. Metal biotechnology is defined as biological technology that utilizes the reactions of various metals in metabolism and also chemical binding by living organisms and biomolecules.

Here, the “metal” in metal biotechnology encompasses –– in addition to typical metals like iron –– all mineral elements, including metalloids such as arsenic and antimony, and nonmetals such as selenium and tellurium, which has properties similar to those of typical metal elements.

Biological reactions are intrinsically materialsaving and energy-saving. Consequently, the metal biotechnology that the authors propose is a key technology that is useful for settling a problem which no physicochemical process can resolve or which no such process can resolve easily.

Readership: Researchers in biotechnology, chemistry and materials science Hardback •300pp (approx.) • Dec 2010 978-981-4267-98-4 • US$149.00

From Bioimaging to Biosensors

Noble Metal Nanoparticles in Biodetection

edited by Lai-Kwan Chau (National Chung Cheng University, Taiwan) & Huan-Tsung Chang (National Taiwan University, Taiwan) • Reviews research on the use of noble metal nanoparticles for bioimaging, biosensing and mass spectrometric bioanalysis, including aspects from analytical chemistry, physical chemistry, materials science, biochemistry, microfluidics and engineering.

• Offers numerous well-illustrated biodetection examples from the authors’ research work.

• Combined authorship from the interdisciplinary team provides a unique multidisciplinary viewpoint for the teaching and research of biodetection.

The development of biodetection techniques for the diagnosis of diseases and environmental analysis of biological agents is an extremely significant problem. Recently, research has begun to explore new imaging and sensing strategies based on nanotechnology. One promising approach is to utilize the extraordinary optical properties of noble metal nanoparticles. The absorption and scattering cross-sections of noble metal nanoparticles are orders of magnitude stronger than those of organic dyes. Thus, these nanoparticles act as excellent sensors and novel contrast agents for optical detection because of their enhanced absorption and scattering, respectively. Moreover, the localized plasmon resonance property of these nanoparticles makes label-free and real-time biodetection possible. This book provides a comprehensive overview of the use of noble metal nanoparticles for bioimaging and biosensing.

Readership: Advanced undergraduate- and graduate-level students in analytical chemistry, biomedical engineering and clinical biochemistry; researchers in nanotechnology, chemistry, biology, biomedical engineering and medicine, especially those with an interest in bioimaging, biosensor or mass spectrometric bioanalysis.

Hardback • 400pp (approx.) • Jan 2011 978-981-4267-24-3 • US$149.00

Handbook of Dynein

edited by Keiko Hirose (National Institute of Advanced Industrial Science and Technology, Japan) & Linda Amos (MRC Laboratory of Molecular Biology, UK) • Draws together current information on dynein’s structure, mechanism and functional roles, to build up an integrated picture.

• Covers information from a wide range of techniques, with each chapter written by an internationally-renowned expert.

• Reveals where new avenues have been opened up, with the potential for a deeper investigation.

• Emphasizes new structural information.

Dyneins are biological molecular motors that move along microtubules and drive a surprisingly wide range of essential cellular processes such as beating of cilia and flagella, vesicular transport and mitosis. Although the protein was discovered nearly half a century ago, research into its complex array of interactions began quite slowly but has progressed with steadily increasing success. The current knowledge about dynein’s mechanisms and functional roles has reached a high level, and new avenues have opened up that are ready for a deeper investigation in this very active field.

This book draws together the impressive amount of information now available on both cytoplasmic and flagellar dyneins and the proteins they directly interact with, combining data obtained with a range of biophysical, biochemical and cell biological methods.

Readership: Researchers and students in life sciences Hardback • 350pp (approx.) • Feb 2011 978-981-4303-33-0 • US$149.00

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Handbook of Active Materials for Medical Devices

Nanostructures in Biological Systems

edited by Andrés Díaz Lantada (Universidad Politécnica de Madrid, Spain)

by Ales Iglic & Veronika Kralj-Iglič (University of Ljubljana, Slovenia)

Advances and Applications

Theory and Applications

• Discusses the great potential of active or intelligent materials for the development of sensors, actuators and multifunctional systems linked to applications in the field of biodevices and medical appliances.

• Analyses the main biological and medical applications of different families of intelligent materials and includes case studies showing complete development processes.

• Features development methodology so as to help future research and development of medical appliances and biodevices.

• Presents the theoretical approach which is useful in describing electrical and elastic phenomena in nanostructures in biological systems.

• Is a new work, in that biophysical methods are used to describe and indicate manipulation of clinically relevant problems, which have hitherto been largely ascribed to biochemical phenomena.

• Includes detailed derivations, which enable the readers to understand to basis of different theoretical approaches.

This book treats all kinds of biodevices that benefit from the use of active materials as sensors or actuators, mainly implantable or quirurgical, for the diagnosis or treatment of different pathologies.

The book surveys recent theoretical as well as experimental results about nanostructures in biological systems and provides some possible applications. In the theoretical part, a unifying approach starting from the single-particle energy, deriving free energy of a system and determining equilibrium by minimizing the free energy, is applied to describing electrical and elastic phenomena. This approach is basic, transparent and simple, so that new and additional systems and interactions can be included by the readers. As theory and experiment have been developed in the same process, they support each other in broadening the knowledge about the system. The potential use of this knowledge in clinically relevant phenomena, such as hemostasis, inflammation and the spreading of cancer, is presented, and some applications in nanotoxicology, such as the interactions between biological membranes and inorganic nanostructures, are described.

Such active or “intelligent” materials are capable of responding in a controlled way to different external physical or chemical stimuli by changing some of their properties. These materials can be used to design and develop sensors, actuators and multifunctional systems with a large number of applications for developing biodevices and medical appliances.

Current work on these fields entails problems related to synthesis, characterization, modelling, simulation, processing and prototyping technologies, as well as device testing and validation, all of which are treated in depth in this book.

Readership: Students and researchers in physics, materials science and bioengineering, especially those working in the field of active or “intelligent” materials for biological or medical applications Hardback • 500pp (approx.) • Feb 2011 978-981-4303-35-4 • US$179.00

Readership: Students and researchers in biophysics, physical chemistry, nanoscience, biology and toxicology.

Hardback • 300pp (approx.) • Feb 2011 978-981-4267-20-5 • US$149.00

Inside the Photon A Journey to Health

by Tony Fleming & Elizabeth Bauer (Biophotonics Research Institute, Australia) • Discusses recent advances in the theory of photonics applied to biophotonics.

• Provides a clear elucidation of resonance as a mechanism for applying electromagnetic and acoustic frequencies and shows that resonant frequencies can be applied both to promote and to inhibit growth.

• Gives new insights into how traditional therapies and medicines might work and how proactive therapy, instead of retroactive repair, can be more feasible.

Over the past decade, biophotonics has appeared as a new department within academic circles across the globe. With experimental work going on for more than a century, application of scientific methods has shown the importance of biophotonics in biological and medical practice.

The book describes the newly discovered layer of biophotonics underlying all atomic chemistry and biochemistry. As with the variety of snowflakes, the range in biological species within flora, for instance, is dependent on this biophotonic layer of interaction within atomic and biomolecular structures. A new range of energies that can be balanced only within biophotonic states is responsible for these innumerable varieties of biological species.

The book gives a fresh impetus to therapies such as homeopathy, acupuncture and traditional Chinese medicine by providing a putative understanding of these therapies. It makes mitosis understood via the cell cycle and explains how electric, acoustic and magnetic fields can induce changes at the biophotonic level. This work thereby shows the possibility of medical therapy without invasive surgery and without the side effects of drug-based therapies.

Readership: Advanced undergraduate- and graduate-level students and researchers in biophotonics, bioelectromagnetics, biophysics, biomathematics, biochemistry, photonics, acoustics and biomedical engineering Hardback • 300pp (approx.) • Feb 2011 978-981-4241-40-3 • US$149.00

Biotechnology and Biomedical Engineering 2011

Transport of Nanoparticles in Tissues

Biomechatronics in Medicine and Health Care

Nanotherapeutics

• Provides a unified approach to the understanding of nanotransport in biological tissues, including its limitations and applicability.

• Contains all the background material necessary to understand structure and functionality of novel nano drug carriers and their delivery pathways.

• Includes a thorough outline of all theoretical, modelling and computational aspects to help readers use the text in the further development or application of the presented body of research.

• Focuses on biomechatronics, an exciting field for research and development by both the engineering and the medical profession.

• Discusses a variety of clinical challenges in medicine and healthcare and demonstrates how to apply biomechatronics in providing better care and service.

• Includes lucid chapters, each of which provides substantial background material to help students and researchers learn the state of the art in this area.

“This book provides state-of-the-art research material in the area of nanotherapeutics. Its content is clear and didactic and reflects modern knowledge and thinking in pharmaceutics. It is a precious book for all types of readers, including students, research scientists, pharmacists from the industry and practitioners from hospitals who want to expand their knowledge about nanomedicine.”

Prof. Jean-Pierre Benoit University of Angers, France

by Petr Kloucek (Université de Neuchâtel, Switzerland)

The book addresses the question of mobility of sub-micron particles in tissues, complex bioenvironments and, specifically, in tumours. This area is profoundly connected with application of novel drug carriers in nanomedicine. The understanding of limitations pertaining to nanotransport of both biological and bio-MEMbased carriers plays a fundamental role in targeted drug delivery, imaging and plant nutrition delivery, to mention just a few fields that benefit from theoretical insights into the particles’ nanotransport in biological tissues.

The book provides both mesoscopic and macroscopic descriptions of the interstitial tissue matrix that plays a fundamental role in the nanotransport. A detailed description of the governing equations provides a framework for relating the underlying tissue structure with basic flow parameters. One of the novel aspects the book provides is the modelling of turtuosity and its relation to the apparent diffusion. It contains a number of applications of the presented theory relating to specific tumour structures and a variety of drug nano-carriers with respect to their potential to deliver various drugs to cancerous cells.

Readership: Practitioners in the field of nanomedicine in combination with drug delivery or imaging; PhD as well as postgraduate students of medicine, physics, chemistry and mathematics.

Hardback •350pp (approx.) • Mar 2011 978-981-4267-06-9 • US$149.00

edited by Raymond Tong (The Hong Kong Polytechnic University, Hong Kong)

This book is targeted at both engineering and medical professionals interested in biomechatronics. There is a growing need for biomechatronic devices in the medical field, and many research groups are developing different systems in this area. This development can support the provision of better healthcare.

The book presents experts’ insights into the emerging technologies and developments that are or will be applied in medical professions to overcome a variety of clinical challenges and then demonstrates how to apply biomechatronics in providing better care and service. It also incorporates new and exciting multidisciplinary areas of research across the medical and engineering fields, such as the robotic therapeutic training system for stroke rehabilitation, exoskeletons for persons with disability to help them perform daily activities, functional electrical stimulation and wireless active capsule endoscopy.

Each chapter provides substantial background material relevant to a particular subject. Therefore the work is an indispensable primary reference for students and researchers in the stimulating field of biomechatronics.

Readership: Students, researchers and industry professionals in biomedical engineering and medical physics.

Hardback • 300pp (approx.) • Mar 2011 978-981-4241-61-8 • US$149.00

Drug Delivery Concepts in Nanoscience

edited by Alf Lamprecht (Université de FrancheComté, France)

An important and exciting aspect in the newly developing field of nanomedicine is the use of nanoparticle drug delivery systems that allows for innovative therapeutic approaches. Because of their small size, these drug delivery systems are promising tools in therapeutic approaches such as selective or targeted drug delivery towards a specific tissue or organ, enhanced drug transport across biological barriers and intracellular drug delivery.

This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g., diabetes, cancer, inflammation) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. From this concise book, readers will gain an insight into the basics of nanoparticle preparation and find a more detailed account of what is therapeutically feasible by using nanoparticle approaches.

Readership: Academia and research laboratories in the biomedical and pharmacological fields.

Useful for postgraduate students and researchers in the pharmaceutical industry.

Hardback • 292pp • Jul 2008 978-981-4241-02-1 • US$155.00

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Nanobiotechnology and Nanobiosciences

by Claudio Nicolini (University of Genoa, Italy) “This is an impressive compendium of the work of Professor Nicolini and others in the critical area of nanotechnology. Wide-ranging in its scope, it addresses the crucial junction between nanotechnology and biology. The label-free detection methods covered here will provide powerful new tools for understanding molecular interactions, and the nanoscale materials will find far-reaching applications in both biology and engineering.”

Prof. Joshua LaBaer Harvard University, USA

Nanomedicine

Nanopathology

edited by Mingjun Zhang (University of Tennessee at Knoxville, USA) & Ning Xi (Michigan State University, USA)

by Antonietta Gatti (University of Modena & Reggio Emilia, Italy) & Stefano Montanari (Nanodiagnostics srl, Italy)

A Systems Engineering Approach

“Taking a unique, systems perspective, this book not only covers fundamental information on nanomedicine, but also provides an account of modeling, simulation, and experimental tools for dealing with challenges at the interface between nanotechnology and medicine. It is an excellent reference for researchers and students in this burgeoning field.”

Prof. Xiaobo Tan Michigan State University, USA

Nanobiotechnology is capable of yielding a scientific and industrial revolution, as envisioned by the numerous programs on nanotechnology launched over the last decade by councils and governments worldwide, beginning in late 1995 by the Science and Technology Council in Italy,

by President Clinton of the USA and recently

by Russian Prime Minister Putin of the Russian Federation.

This book offers a fundamental and comprehensive overview of nanomedicine from a systems engineering perspective, making it the first book in the field of quantitative nanomedicine based on systems theory. It will advance the knowledge of nanoscale science and engineering by efficiently employing quantitative tools for fundamental biomedical engineering and biological science research.

This volume introduces, in a coherent and comprehensive fashion, the Pan Stanford Series on Nanobiotechnology by defining and reviewing the major sectors of nanobiotechnology and nanobiosciences with respect to the most recent developments. It covers the basic principles and main applications of nanobiotechnology as an emerging field at the frontiers of biotechnology and nanotechnology, with contributions from leading scientists active in their respective specialties.

The book starts by introducing the concept of nanomedicine and provides basic mathematical modeling techniques that can be used to model nanoscale biomedical and biological systems. It then demonstrates how this idea can be used to model and analyze the central dogma of molecular biology, tumor growth and the immune system. Broad applications of the idea are further illustrated by Bayesian networks, multiscale and multiparadigm modeling and AFM engineering.

This book is Volume 1 of the Pan Stanford Series on Nanobiotechnology.

The book demonstrates how systems engineering, which has been very successful in conventional engineering, may help with nanomedicine.

Readership: Researchers and students in nanobiotechnology and nanobiosciences.

Readership: Bioengineers, systems engineers and mathematicians.

Hardback • 380pp • Nov2008 978-981-4241-38-0 • US$119.00

Hardback • 360pp • Mar 2009 978-981-4241-36-6 • US$149.00

The Health Impact of Nanoparticles

Enormous funds are currently being invested in nanotechnology, yet very little is known about how its products and by-products can interfere with both end users and people involved in their manufacture. Similar scenarios are already widely known in the history of science, such as the exploitation of radioactivity or the controversial issue of genetically modified organisms. As nanoparticles are more or less voluntarily produced, they are almost uncontrollably disseminated in the environment and in organisms and thus constitute a growing concern. By describing the impact of nanoparticles (and microparticles) on human and animal health, this book offers the first criteria for preventing potential problems deriving from these particles.

Contents: How the Whole Thing Began or the Logic Path Towards a Discovery; In-Vitro and In-Vivo Biological Behavior of Micro and Nanoparticles; Clinical Cases: Lung, Blood, Liver, Kidney, Digestive System, Vessels, Sperm; Six ”Detective Stories”; War and Nanoparticles; Nanoparticles in the Environment and Working Places; Nanoparticles in Food, Cosmetics and Other Products; New York 9/11; The Future and Prevention Criteria.

Readership: Scientists in academia and industry, ecologists, military personnel, and medical doctors. Can be used as a basis for new research and as a textbook for graduate students of different subjects (medicine, biology, engineering, etc.).

Hardback • 312pp • Mar 2008 978-981-4241-00-7 • US$135.00 Copyright © Apple Inc

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Biotechnology and Biomedical Engineering 2011

Nano Meets Macro

Science at the Nanoscale

Carbon Nanotubes

edited by Kamilla Kjølberg & Fern Wickson (University of Bergen, Norway)

by Chin Wee Shong, Sow Chorng Haur & Andrew T. S. Wee (National University of Singapore, Singapore)

edited by SIlvana Fiorito (Università degli studi di Roma la Sapienza, Italy)

“The editors have compiled a beautifully diverse and timely collection on the social and cultural aspects of nano-scale science and engineering.

With informed academic analysis, fresh-fromthe-field NGO experience, and provocative images, fiction and poetry, their contribution is as multifaceted as nano itself.”

Prof. David Guston Arizona State University, USA

“This book provides a very detailed and interesting overview of the fundamental principles of nanoscience, discusses the background of several nanoscience experimental techniques, and sheds light on some of the visionary and important applications in the truly interdisciplinary area of nanotechnology.”

Profs. Wael Mamdouh & Flemming Besenbacher University of Aarhus, Denmark

This book explores the enormous diversity in social perspectives on the emergence of nanoscale sciences and technologies. The diversity is presented by pointing to four nodes of interest, the nodes where Nano meets Macro: In the Making, In the Public Eye, In the Big Questions and In the Tough Decisions. Each node draws attention to important research lines and pertinent issues.

Nano meets Macro is designed especially for use in interdisciplinary teaching and discussions with natural science students, but the richness of issues and perspectives makes it of interest to all researchers, practitioners and non-academics wanting an introduction to social perspectives on nanoscale sciences and technologies. To stimulate discussion the book includes pieces of science fiction and visual arts, as well as questions for reflection after each chapter.

Nanotechnology is one of the most important growth areas of this century. Nanoscience, the science underpinning nanotechnology, is a multidisciplinary subject covering atomic, molecular and solid state physics, as well as much of chemistry. Nanostructures are known to exhibit novel and improved material properties, fundamentally because the physical and chemical properties are very different when dimensions are reduced to the nanometer range. This book aims to introduce the various basic principles and knowledge needed for students to understand science at the nanoscale.

Social Perspectives on Nanoscience and Nanotechnology

Contents: “Historical Context of the US National Nanotechnology Initiative (H. Fogelberg); Questioning Interdisciplinarity: What roles for laboratory based social science? (R. Doubleday & A. Viseu); The Science and Politics of Nano Images (R. Strand & T. Birkeland); Poetry from the Laboratory (Hildegard Lee); Eigler’s Eyes 2 (Chris Robinson); Triangular Masterpiece no. 5 (K. B. Kjølberg); NanoFireball (C. Orfescu); The Slippery Nature of Nano-Enthusiasm (R. Sparrow); and many more.

An Introductory Textbook

Many ideas proposed in nanotechnology are futuristic, although some have immediate technological applications. The core scientific principles of all nanotechnology applications, however, are grounded in physics and chemistry.

There are currently numerous specialized nanoscience and nanotechnology-related texts or monographs at the graduate and senior undergraduate level. This textbook is targeted at the junior undergraduate level and is also expected to serve as a reference text for advanced learners at pre-university and senior high school.

It has evolved from the authors’ own teaching experience at tertiary institutions.

Readership: General interest.

Readership: This book is suitable for science undergraduates and can be used as a reference for pre-university science students.

Hardback • 596pp • Apr 2010 978-981-4267-05-2 • US$99.00

Hardback • 228pp • Aug 2009 978-981-4241-03-8 • US$88.00

Angels or Demons?

“This book is a must for every materials scientist and all those who appreciate rational answers to questions they might not dare to ask.”

Prof. Marie-Louise Saboungi Centre de Recherche sur la Matière Divisée, France

“Carbon Nanotubes: Angels or Demons? represents a soft touch of the most updated topics concerning nanotechnology ... Every aspect is presented in an almost holistic and very promising effort.”

Prof. Giorgia Pastorin National University of Singapore, Singapore

“Finally, a book that gathered the latest and most contrasted information on toxicity of carbon nanotubes.”

Dr. Isabel Obieta INASMET-Tecnalia, Spain The field of carbon nanoparticles toxicity is, at present, fragmented and contradictory, oscillating between enthusiastic raptures and bitter disappointments. This important book presents an overall, unitary view of the carbon nanoparticle world, in which both the positive and negative aspects of these recently discovered nanomaterials are critically described and elucidated.

The book provides an exhaustive account of carbon nanotubes toxicity, mechanisms of toxicity and biocompatibility towards human and animal organisms as well as the entire biological environment. The detailed description of the physicochemical properties of these nano-objects will help facilitate discussion on their future applications in the biomedical field.

Readership: Academics, postgraduate students, researchers and scientists in nanomaterials and nanostructures.

Hardback • 164pp • May 2008 978-981-4241-01-4 • US$109.00

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Japan Pan Stanford Publishing c/o United Publishers Services Ltd. 1-32-5, Higashi-Shinagawa Shinagawa-ku, Tokyo 140-0002 Japan Tel: +81 3 5479 7255 Fax: +81 3 5479 7307 sales.japan@panstanford.com

India Pan Stanford Publishing c/o Cambridge University Press India Cambridge House 4381/4 Ansari Road Daryaganj, New Delhi 110002 India Tel: + 91 11 4354 3500 Fax: + 91 11 2328 8534 sales.india@panstanford.com

Asia & Rest of the World Pan Stanford Publishing Pte. Ltd. Penthouse Level Suntec Tower 3 8 Temasek Boulevard Singapore 038988 Tel: +65 6829 2268 Fax: +65 6866 3636 sales.asia@panstanford.com