PATOLOGI SISTEMIK II (PAP 442)
PATOLOGI ALAT REPRODUKSI ALAT KELAMIN JANTAN Dr. drh. Eva Harlina, MSi. Bagian Patologi Departemen Klinik, Reproduksi dan Patologi Fakultas Kedokteran HewanHewan-IPB Jl. Agatis Kampus IPB Darmaga, Bogor - 16680
MALE REPRODUCTIVE SYSTEM
• Testis • Excretory duct • Accessory glands • Penis and pprepuce p
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MALE REPRODUCTIVE SYSTEM
• Testis Seminiferous tubules (contain germ cells in various stage of maturation), Sertoli cell, cell Leydig cells
• Excretory duct: duct: epididymis, vas deferens • Accessory glands glands:: seminal vesicles, prostate
• Penis and prepuce Patologi Alat Kelamin Jantan
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DISEASES OF THE MALE REPRODUCTIVE SYSTEM
Developmental disorders
Diseases of the scrotum and contents
Diseases of the accessory glands
Diseases of the penis and prepuce
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DEVELOPMENTAL DISORDERS MAJOR ANOMALIES
Sexual dimorphism p
Segmental aplasia of epididymis
Cryptorchidism
Testicular hypoplasia
Spermatic granuloma Patologi Alat Kelamin Jantan
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SEXUAL DIMORPHISM Errors of chromose, gonadal or phenotypic sex 1. Sex chromosomes (structure and number). a. Abnormal structure of Y (isochromosome) Female phenotype H Hypoplasctic l ti gonads d b. Duplication of one of the sex chromosome (XXY, XYY) Testicular hypoplasia Kli f lt ’ syndrome Klinefelter’s d (tricolor (t i l male l cat) t) Patologi Alat Kelamin Jantan
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SEXUAL DIMORPHISM …
2 Hermaprhodites 2.
• XY genotype • Androgen receptor disorder • Abnormal gonads (have both testicular test cu a a and do ovarium a u ttissue) ssue)
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Male pseudo pseudohermaphrodite: XY chromosome
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MINOR ANOMALIES
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MINOR ANOMALIES
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DISEASES OF THE SCROTUM AND CONTENTS
The scrotum
T i and Testis d Epididymis E idid i
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DISEASES OF THE SCROTUM ď‚˜
Dermatitis Trauma Trauma Frosbite E i Environmental t l iirritants it t Chorioptes bovis
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Neoplasma p Mast cell tumor Melanoma Hemangioma Patologi Alat Kelamin Jantan
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DISEASES OF TESTIS AND EPIDIDYMIS Decreased size
C t hidi Cryptorchidism
Hypoplasia yp p
Testicular degeneration
Segmental aplasia
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Increased size
Spermatic granuloma of epididymis
Epididymitis
Orchitis
Testicular neoplasia: Seminoma Sertoli cell tumor Interstitial cell tumor Patologi Alat Kelamin Jantan
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Decreased size …
CRYPTORCHIDISM Incomplete descent of testis
Oft unilateral Often il t l
Hypoplasia or atrophy
Testis is small, fibrotic, hyaline thickening of tubular basement membrane membrane, degeneration of germinal epithelium, only a few spermatogonia remain remain, normal Sertoli cells
Prone P tto neoplasia l i (S (Sertoli t li CT CT, seminoma) i ) Patologi Alat Kelamin Jantan
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Decreased size …
HYPOPLASIA
Mild to severe
Unilateral hypoplasia
Ab Abnormality lit off specific ifi genes, endocrine, d i cytogenic
Related to poor general nutrition, Zn deff
HP: hypoplastic tubules, lined by sertoli cells, a few stem cells and spermatogonia Patologi Alat Kelamin Jantan
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Decreased size …
TESTICULAR ATROPHY Reduce in size after puberty
Testicular degeneration
HP: deg. of the seminiferous tubules
Causes by: inflammation, obstruction of flow of spermatozoa (segmental aplasia, injury of epididymis, torsion of spermatic cord)
Systemic injurious factor: hypovitaminosis A, Zn, antibiotic, toxins, estrogen produced by sertoli cell tumor Patologi Alat Kelamin Jantan
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Some Causes of Testicular Degeneration
Advancing age Epididymitis Chemicals Heat Hormones Metal compound toxicosis Neoplasia Nutritional disorders Plants Radiation Stress Trauma Ultrasound Viral infection Patologi Alat Kelamin Jantan
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EPIDIDYMITIS AND SPERMATIC GRANULOMA
Inflammation, testicular neoplasia
Spermatic granuloma: congenital obstruction inflammation as respon to obstruction, spermiostatis
Epididymitis is almost accompanied by spermatic granuloma and periorchitis
Cause testicular degeneration
B. abortus, E. coli Patologi Alat Kelamin Jantan
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Increased c eased ssize e
Spermatic granuloma of epididymis
Epididymitis
Orchitis
Periorchitis
Testicular neoplasia S i Seminoma Teratoma Sertoli cell tumor Interstitial cell tumor
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ORCHITIS
Extension of epididymitis
Hematogenous
B abortus, B. b t B B. suis, i C. pseudotuberculosis
Intratubular orchitis, necrotizing orchitis, granulomatous l t orchitis hiti (M. (M bovis, b i mycotic orchitis) orchitis) Patologi Alat Kelamin Jantan
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TESTICULAR NEOPLASIA
Common in older dog g
Arise from germ cells
Seminoma
I t titi l cellll ttumors Interstitial
Sertoli cell tumors: feminizing effect (Gynecomastica Gynecomastica:: enlargement of mammary gland) Patologi Alat Kelamin Jantan
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Veneric Sarcoma Kulit hingga ke mukosa Sel tumor menyebar seperti anggur
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stroma
stroma
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Sertoli Cell Tumor Stroma menebal
Tubuli seminiferi berisi sel Sertoli yang berproliferasi
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Ukuran tubuli seminiferi bervariasi: membesar, membesar mengecill
Stroma menebal 12
Sel Sertoli
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