slide traktus urogenital jantan

PATOLOGI SISTEMIK II (PAP 442)

PATOLOGI ALAT REPRODUKSI ALAT KELAMIN JANTAN Dr. drh. Eva Harlina, MSi. Bagian Patologi Departemen Klinik, Reproduksi dan Patologi Fakultas Kedokteran HewanHewan-IPB Jl. Agatis Kampus IPB Darmaga, Bogor - 16680

MALE REPRODUCTIVE SYSTEM

• Testis • Excretory duct • Accessory glands • Penis and pprepuce p

Patologi Alat Kelamin Jantan

2

MALE REPRODUCTIVE SYSTEM

• Testis Seminiferous tubules (contain germ cells in various stage of maturation), Sertoli cell, cell Leydig cells

• Excretory duct: duct: epididymis, vas deferens • Accessory glands glands:: seminal vesicles, prostate

• Penis and prepuce Patologi Alat Kelamin Jantan

3

Patologi Alat Kelamin Jantan

4

Patologi Alat Kelamin Jantan

5

Patologi Alat Kelamin Jantan

6

DISEASES OF THE MALE REPRODUCTIVE SYSTEM 

Developmental disorders



Diseases of the scrotum and contents



Diseases of the accessory glands



Diseases of the penis and prepuce

Patologi Alat Kelamin Jantan

7

DEVELOPMENTAL DISORDERS MAJOR ANOMALIES 

Sexual dimorphism p



Segmental aplasia of epididymis



Cryptorchidism



Testicular hypoplasia



Spermatic granuloma Patologi Alat Kelamin Jantan

8

SEXUAL DIMORPHISM Errors of chromose, gonadal or phenotypic sex 1. Sex chromosomes (structure and number). a. Abnormal structure of Y (isochromosome) Female phenotype H Hypoplasctic l ti gonads d b. Duplication of one of the sex chromosome (XXY, XYY) Testicular hypoplasia Kli f lt ’ syndrome Klinefelter’s d (tricolor (t i l male l cat) t) Patologi Alat Kelamin Jantan

9

SEXUAL DIMORPHISM …

2 Hermaprhodites 2.

• XY genotype • Androgen receptor disorder • Abnormal gonads (have both testicular test cu a a and do ovarium a u ttissue) ssue)

Patologi Alat Kelamin Jantan

10

Male pseudo pseudohermaphrodite: XY chromosome

Patologi Alat Kelamin Jantan

11

Patologi Alat Kelamin Jantan

12

MINOR ANOMALIES

Patologi Alat Kelamin Jantan

12

MINOR ANOMALIES

Patologi Alat Kelamin Jantan

13

DISEASES OF THE SCROTUM AND CONTENTS 

The scrotum



T i and Testis d Epididymis E idid i

Patologi Alat Kelamin Jantan

14

DISEASES OF THE SCROTUM ď‚˜

Dermatitis Trauma Trauma Frosbite E i Environmental t l iirritants it t Chorioptes bovis

ď‚˜

Neoplasma p Mast cell tumor Melanoma Hemangioma Patologi Alat Kelamin Jantan

15

Patologi Alat Kelamin Jantan

16

Patologi Alat Kelamin Jantan

17

DISEASES OF TESTIS AND EPIDIDYMIS Decreased size 

C t hidi Cryptorchidism



Hypoplasia yp p



Testicular degeneration



Segmental aplasia

Patologi Alat Kelamin Jantan

18

Increased size 

Spermatic granuloma of epididymis



Epididymitis



Orchitis



Testicular neoplasia: Seminoma Sertoli cell tumor Interstitial cell tumor Patologi Alat Kelamin Jantan

19

Decreased size …



CRYPTORCHIDISM Incomplete descent of testis



Oft unilateral Often il t l



Hypoplasia or atrophy



Testis is small, fibrotic, hyaline thickening of tubular basement membrane membrane, degeneration of germinal epithelium, only a few spermatogonia remain remain, normal Sertoli cells



Prone P tto neoplasia l i (S (Sertoli t li CT CT, seminoma) i ) Patologi Alat Kelamin Jantan

20

Patologi Alat Kelamin Jantan

21

Patologi Alat Kelamin Jantan

22

Decreased size …

HYPOPLASIA 

Mild to severe



Unilateral hypoplasia



Ab Abnormality lit off specific ifi genes, endocrine, d i cytogenic



Related to poor general nutrition, Zn deff



HP: hypoplastic tubules, lined by sertoli cells, a few stem cells and spermatogonia Patologi Alat Kelamin Jantan

23

Patologi Alat Kelamin Jantan

24

Decreased size … 

TESTICULAR ATROPHY Reduce in size after puberty



Testicular degeneration



HP: deg. of the seminiferous tubules



Causes by: inflammation, obstruction of flow of spermatozoa (segmental aplasia, injury of epididymis, torsion of spermatic cord)



Systemic injurious factor: hypovitaminosis A, Zn, antibiotic, toxins, estrogen produced by sertoli cell tumor Patologi Alat Kelamin Jantan

25

Some Causes of Testicular Degeneration              

Advancing age Epididymitis Chemicals Heat Hormones Metal compound toxicosis Neoplasia Nutritional disorders Plants Radiation Stress Trauma Ultrasound Viral infection Patologi Alat Kelamin Jantan

26

Patologi Alat Kelamin Jantan

27

Patologi Alat Kelamin Jantan

28

EPIDIDYMITIS AND SPERMATIC GRANULOMA 

Inflammation, testicular neoplasia



Spermatic granuloma: congenital obstruction inflammation as respon to obstruction, spermiostatis



Epididymitis is almost accompanied by spermatic granuloma and periorchitis



Cause testicular degeneration



B. abortus, E. coli Patologi Alat Kelamin Jantan

29

Patologi Alat Kelamin Jantan

30

Increased c eased ssize e 

Spermatic granuloma of epididymis



Epididymitis



Orchitis



Periorchitis



Testicular neoplasia S i Seminoma Teratoma Sertoli cell tumor Interstitial cell tumor

Patologi Alat Kelamin Jantan

31

Patologi Alat Kelamin Jantan

32

Patologi Alat Kelamin Jantan

33

Patologi Alat Kelamin Jantan

34

ORCHITIS 

Extension of epididymitis



Hematogenous



B abortus, B. b t B B. suis, i C. pseudotuberculosis



Intratubular orchitis, necrotizing orchitis, granulomatous l t orchitis hiti (M. (M bovis, b i mycotic orchitis) orchitis) Patologi Alat Kelamin Jantan

35

Patologi Alat Kelamin Jantan

36

Patologi Alat Kelamin Jantan

37

TESTICULAR NEOPLASIA 

Common in older dog g



Arise from germ cells



Seminoma



I t titi l cellll ttumors Interstitial



Sertoli cell tumors: feminizing effect (Gynecomastica Gynecomastica:: enlargement of mammary gland) Patologi Alat Kelamin Jantan

38

Patologi Alat Kelamin Jantan

39

Patologi Alat Kelamin Jantan

40

Patologi Alat Kelamin Jantan

41

Patologi Alat Kelamin Jantan

42

Veneric Sarcoma Kulit hingga ke mukosa Sel tumor menyebar seperti anggur

8

stroma

stroma

9

10

Sertoli Cell Tumor Stroma menebal

Tubuli seminiferi berisi sel Sertoli yang berproliferasi

11

Ukuran tubuli seminiferi bervariasi: membesar, membesar mengecill

Stroma menebal 12

Sel Sertoli

13