Roberto Ferrari Disclosures Speaker’s bureau:
Servier, Bayer, Roche Boehringer Ingelheim
Research grant:
Servier, Novartis, Roche Boehringer Ingelheim,
Advisory Board:
Servier, Bayer, Roche Boehringer Ingelheim
Chronic Cardiovascular Disease Registry
•Promoted by the ESC •Conducted by the ESC, EAPCI and WG on Peripheral Circulation
Why?
Background •CVD is the first cause of
mortality despite modern treatment and prevention measures
•Most recent epidemiological data were released in 2008
Background •Epidemiology has changed with aging and improved prognosis
•West to East gradient of CVD
prevalence and mortality exists
•This is inversely related to per
capita and gross national product
CVD death rates 1994 - 2004
%
Finland
UK
Albania
Ukraine
Background •Atherosclerosis is a systemic disease
•CVD is often associated with- Cerobrovascular disease - Lower extremity artery disease (LEAD)
Background • Stroke mortality ranges from
10% to 30%, morbidity is high
• LEAD increase from 3% to 20% with aging
But
•Data on presentation and
management of CVD and PAD come from clinical trials or registries focusing on specific manifestations of the disease
•There are no European
contemporary data reflecting daily practice of this epidemic
ESC CVD Registry will provide a picture of:
•CV atherosclerosis •Its risk factor •Its clinical implication •Its treatment (preventative and therapeutic)
Registry: questions •What are the demographics and clinical profiles of the CVD and PAD population?
•What is the current daily treatment?
•Is there adherence to Guidelines and evidence-based practice?
Registry: questions •What are the changes during follow-up?
•What are the geographic
variations in management?
•What are the determinants of long-term prognosis?
ESC CVD Registry: 4 cohorts 1
•Consecutive P with CAD
undergoing urgent PCI for NSTE ACS -Enrolment: cath lab
2
•Consecutive P undergoing
elective PCI for stable angina -Enrolment: cath lab
ESC CVD Registry: 4 cohorts
•
3 Consecutive P with PAD (carotid
•
or limb) undergoing interventions -Enrolment: cath lab -Ancillary study: diabetic foot
4 Consecutive P with stable CAD
-Enrolment: general hospital
ESC CVD Registry: methods
•Enrolment: 1 day per week for 6 months
•Follow-up:
1 visit at 6 months
National and European Networks
•Cohort 1: 1 centre per 2 million
1
inhabitants. (10 centres / country, ranging 5-10 / country)
2
•Cohort 2: 1 centre per 2 million
inhabitants. (10 centres / country, ranging 5-10 / country)
National and European Networks
•
3 Cohort 3: all centres performing
more than 30 peripheral procedures per year per country (5-10 centres / country) 4
•Cohort 4: 15-30 general hospitals or clinics (no interventional or surgical facilities)
Participating countries •Northern •Eastern Lithuania Norway
•Southern Turkey Portugal Italy Greece
Russia Romania Bulgaria Poland
•Central
France Germany Netherlands
Cohort 1*
Cohort 2*
Cohort 3**
Cohort 4***
CAD with NSTE-ACS Urgently revascularised
Chronic CAD Electively revascularised
PAD All revascularised
Chronic CAD Non revascularised
20 P per centre
10 P per centre
10 P per centre
20 P per centre
2600 patients
1300 patients
910 patients
3900 patients
Total population 8711 patients * 10 centres per country per 13 countries ** 7 centres per country per 13 countries *** 15 centres per country per 13 countries
ESC CVD Registry: design
•General observational registry
•Pilot phase
(1 year, 13 countries)
•Long term longitudinal
ESC CVD Registry: structure •Executive Committee Roberto Ferrari (Chairman, Exec Comm) Michel Komajda(Chairman, Steering Comm) Francesco Cosentino Gabriel Steg Aldo Maggioni Marco Valgimigli Luigi Tavazzi Franz Weidinger
•Steering Committee
Each national coordinator indicated by National Society President
ESC CVD Registry: organisation
•EORP team based at HH •Database collected and analysed at HH
•Progress published on a protected website with
ESC CVD Registry: timing • Centre selection • Regulatory procedures • FPFV • LP enrolment • LPLV • Database locked • Final result presentation
Oct-Nov 2012 Nov 2012-Jan 2013 Feb 2013 Oct 2013 April 2014 June 2014 ESC Congress 2014