Metformin – The most common and famous prescribed medicine

Metformin â&#x20AC;&#x201C; The most common and famous prescribed medicine

Add15years.com Add15years.in Author: (Prof.) Dr. S. Om Goel, MD/DM From family of doctors from AIIMS, MAMC& Delhi University MD Medicine, USA DM/Fellowship, USA

Metformin – The most common and famous prescribed medicine    

Metformin (1,1-dimethylbiguanide), a biguanide derivate and its chemical structure is related to guanidine. Insulin sensitizer Most widely prescribed drug to treat hyperglycemia, at least 120 million user worldwide. Monotherapy & in combination with all antidiabetic.

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History • • • •

Metformin was first prepared in 1922 by the Dublin chemists Jean sterne wasthe first to try metformin on humans for the treatment of diabetes. He coined the name “Glucophage” for the drug and published his results in 1957. Metformin was introduced to the United Kingdom in 1958, France in 1957, and Canada in 1972.

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Popular Brands • • • • • • • • • •

Glucophage Metformin Hydrochloride ER Glumetza Rioment Fortamet Glucophage XR Diamin Formin Met – 500 Bigomet

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Mechanism of action Decrease hepatic glucose production through a mild inhibitions of the mitochondrial respiratory-chain. Decrease intestinal absorption of glucose. Anti-oxidative properties of metformin on endothelial cells www.add15years.com www.add15years.in

Actions of metformin Anti-obesity effects: • Decreased appetite • Increased GLP-1 sections Anti-hyperglycemic effects: • Decreased intestinal carbohydrate absorption • Inhibition of hepatic gluconeogenesis • Enhancement of insulin-stimulated glucose transport in the skeletal muscle.

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Side Effect • • • • • •

Metallic taste in the mouth Gastrointestinal (anorexia, cough, vomiting, abdominal discomfort) Vitamin B12 deficiency Lactic acidosis Reduce appetite Fatigue

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AVAIL OFFER N OW

ADD100RsOFF ADD100%OFF Author: (Prof.) Dr. S. Om Goel, MD/DM From family of doctors from AIIMS, MAMC & Delhi University MD Medicine, USA DM/Fellowship, USA

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Metformin – The most common and famous prescribed medicine

Published on Dec 23, 2020

Diabetes or high blood sugar today has become as common issue in every family life. Without even realizing we can manage diabetes, if we accept it easily. There is a phase between our normal blood sugar and prediabetes. So, during prediabetes if we start medications along with diet management and increase level of activity, we can really delay any complications for 30 to 40 years. Whenever we think of diabetes, kidney failure and insulin are two factors. Kidney failure is not the only thing. We can become blind or have heart attack. We can lose sensations in our feet leading to amputation of our legs. Everybody knows diabetes because it is so common, every drug company is making medicines and now there are 13 groups of excellent medications available and together they can really keep us very healthy. Last but not the least, we really have to connect with our doctor and a dietitian and seek counseling. You will feel good, healthy & have no symptoms for long and will be very tempting not to take any medicat

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