WHAT IS PREZCOBIX®?
• It is not known if PREZCOBIX® is safe and effective in children under 18 years of age. • When used with other antiretroviral medicines to treat HIV-1 infection, PREZCOBIX® may help: ○ reduce the amount of HIV-1 in your blood. This is called “viral load.” ○ increase the number of CD4+ (T) cells in your blood that help fight off other infections. ®
• PREZCOBIX is always taken in combination with other HIV medications for the treatment of HIV-1 infection in adults. PREZCOBIX® should be taken once daily with food. • PREZCOBIX® does not cure HIV-1 infection or AIDS, and you may still experience illnesses associated with HIV-1 infection. You must keep taking HIV-1 medicines to control HIV-1 infection and decrease HIV-related illnesses. • Ask your healthcare provider if you have any questions on how to prevent passing HIV to other people. • Please read the Important Safety Information below and talk to your healthcare provider to learn if PREZCOBIX® is right for you.
IMPORTANT SAFETY INFORMATION What is the most important information I should know about PREZCOBIX®? ®
• PREZCOBIX may cause liver problems. Some people taking PREZCOBIX® may develop liver problems which may be life-threatening. Your healthcare provider should do blood tests before and during your treatment with PREZCOBIX.® ○ Chronic hepatitis B or C infection may increase your chance of developing liver problems. Your healthcare provider should check your blood tests more often. ○ Signs and symptoms of liver problems include dark (tea-colored) urine, yellowing of your skin or whites of your eyes, pale-colored stools (bowel movements), nausea, vomiting, pain or tenderness on your right side below your ribs, or loss of appetite. Tell your healthcare provider if you develop any of these symptoms. • PREZCOBIX® may cause severe or life-threatening skin reactions or rash. Sometimes these skin reactions and skin rashes can become severe and require treatment in a hospital. Call your healthcare provider right away if you develop a rash. ○ Stop taking PREZCOBIX® and call your healthcare provider right away if you develop any skin changes with symptoms such as fever, tiredness, muscle or joint pain, blisters or skin lesions, mouth sores or ulcers, red or inflamed eyes like “pink eye” (conjunctivitis). ®
• PREZCOBIX, when taken with certain other medicines, can cause new or worse kidney problems, including kidney failure. Your healthcare provider should check your kidneys before you start and while you are taking PREZCOBIX.®
Ergostat®, Medihaler®, Migergot®, Wigraine®, Wigrettes®), methylergonovine (Methergine®), lovastatin or a product that contains lovastatin (Altoprev®, Advicor®, Mevacor®), lurasidone (Latuda®), oral midazolam (Versed®), phenobarbital (Luminal®), phenytoin (Dilantin®, Dilantin-125®, Phenytek®), pimozide (Orap®), ranolazine (Ranexa®), rifampin (Rifadin®, Rifater®, Rifamate®, Rimactane®), sildenafil (Revatio®) when used for pulmonary arterial hypertension (PAH), simvastatin or a product that contains simvastatin (Simcor®, Vytorin®, Zocor®), St. John’s Wort (Hypericum perforatum) or a product that contains St. John’s Wort, or triazolam (Halcion®). • Serious problems can happen if you take any of these medicines with PREZCOBIX.® What should I tell my healthcare provider before taking PREZCOBIX®? • About all health problems. Tell your healthcare provider if you have liver problems, including hepatitis B or hepatitis C, have kidney problems, are allergic to sulfa (sulfonamide), have diabetes, have hemophilia, or have any other medical condition, are pregnant, breastfeeding, or plan to become pregnant or breastfeed. Tell your healthcare provider if you become pregnant while taking PREZCOBIX.® • About all medicines you take. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines interact with PREZCOBIX.® Keep a list of your medicines to show your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take PREZCOBIX® with other medicines. What are the possible side effects of PREZCOBIX®? • The most common side effects of darunavir, one of the medicines in PREZCOBIX,® include diarrhea, nausea, rash, headache, stomach area (abdominal) pain, and vomiting. • Other possible side effects include: ○ High blood sugar, diabetes or worsening diabetes, and increased bleeding in people with hemophilia have been reported in patients taking protease inhibitor medicines, including PREZCOBIX.® ○ Changes in body fat can happen in people who take HIV-1 medicines. The exact cause and long-term health effects of these changes are not known. ○ Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. These are not all of the possible side effects of PREZCOBIX.® For more information, ask your healthcare provider. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Janssen Products, LP at 1-800-JANSSEN (1-800-526-7736). Please see full Product Information for more details.
®
Who should not take PREZCOBIX ? • Do not take PREZCOBIX® with any of the following medicines: alfuzosin (Uroxatral®), carbamazepine (Carbatrol® Epitol®, Equetro®, Tegretol®, Tegretol-XR®, Teril®) cisapride (Propulsid®), colchicine (Colcrys®, Mitigare®, if you have liver or kidney problems), dronedarone (Multaq®), elbasvir and grazoprevir (Zepatier®), dihydroergotamine (D.H.E.45®, Migranal®), ergotamine tartrate (Cafergot®, Ergomar®,
Janssen Therapeutics, Division of Janssen Products, LP © Janssen Therapeutics, Division of Janssen Products, LP 2017 03/17 068102-170228
061037-161017
• PREZCOBIX® is a prescription HIV-1 (Human Immunodeficiency Virus 1) medicine used with other antiretroviral medicines to treat HIV-1 infection in adults. HIV is the virus that causes AIDS (Acquired Immune Deficiency Syndrome). PREZCOBIX® contains the prescription medicines PREZISTA® (darunavir) and TYBOST® (cobicistat).
“RESISTANCE IS A RISK I TAKE SERIOUSLY.” Everyone is at risk of developing drug resistance. So when deciding on an HIV treatment, think long-term. Once-Daily* PREZCOBIX® has a high genetic barrier to resistance, which may help.
Wisdom inspired by real people
ASK YOUR DOCTOR ABOUT DRUG RESISTANCE AND *
ONCE-DAILY
PREZCOBIX.com
}
“Learning is part of my journey. Asking questions helps me feel more confident.”
PREZCOBIX® (prez-koe-bix) (darunavir and cobicistat) tablets
What is PREZCOBIX® used for? PREZCOBIX® is a prescription HIV-1 (Human Immunodeficiency Virus 1) medicine used with other antiretroviral medicines to treat HIV-1 infection in adults. HIV is the virus that causes AIDS (Acquired Immune Deficiency Syndrome). PREZCOBIX® contains prescription medicines PREZISTA® (darunavir) and TYBOST® (cobicistat). PREZCOBIX® does not cure HIV-1 infection or AIDS. You must keep taking HIV-1 medicines to control HIV-1 infection and decrease HIV-related illnesses. What are the most serious warnings about PREZCOBIX®? • PREZCOBIX® may cause liver problems which may be life-threatening. Tell your healthcare provider right away if you have any symptoms such as: • Vomiting • Dark (tea-colored) urine • Pain or tenderness on your right side below your ribs • Yellowing of your skin or the whites of your eyes • Loss of appetite • Pale-colored stools (bowel movements) • Nausea • PREZCOBIX® may cause severe or life-threatening skin reactions or rashes. Stop taking PREZCOBIX® and call your healthcare provider right away if you develop any skin changes with symptoms below: • Blisters or skin lesions • Fever • Mouth sores or ulcers • Tiredness • Red or inflamed eyes, like “pink eye” (conjunctivitis) • Muscle or joint pain • PREZCOBIX,® when taken with some other medications, can cause new or worse kidney problems, including kidney failure. What do I need to tell my healthcare provider? Tell your healthcare provider if you: • Have liver problems, including hepatitis B or hepatitis C • Have kidney problems • Are allergic to sulfa (sulfonamide) • Have diabetes • Have hemophilia • Have any other medical condition
• Are pregnant or plan to become pregnant. (It is not known if PREZCOBIX® will harm your unborn baby. Tell your healthcare provider if you become pregnant while taking PREZCOBIX.®) • Are breastfeeding or plan to breastfeed. Do not breastfeed if you take PREZCOBIX® because it is unknown if PREZCOBIX® can pass into your breast milk. You should not breastfeed if you have HIV-1 because of the risk of passing HIV to your baby.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medications may prevent PREZCOBIX® from working or cause increased side effects. Do not start taking a new medicine without telling your healthcare provider. Who should not take PREZCOBIX®? • Do not take PREZCOBIX® with any of the following medicines: alfuzosin (Uroxatral®), carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®, Tegretol-XR®, Teril®), cisapride (Propulsid®), colchicine (Colcrys®, Mitigare®, if you have liver or kidney problems), dronedarone (Multaq®), elbasvir and grazoprevir (Zepatier®), dihydroergotamine (D.H.E.45®, Migranal®), ergotamine tartrate (Cafergot ®, Ergomar ®, Ergostat ,® Medihaler,® Migergot,® Wigraine®, Wigrettes®), methylergonovine (Methergine®), lovastatin or a product that contains lovastatin (Altoprev,® Advicor,® Mevacor ®), lurasidone (Latuda®), oral midazolam (Versed®), phenobarbital (Luminal®), phenytoin (Dilantin®, Dilantin-125®, Phenytek®), pimozide (Orap®), ranolazine (Ranexa®), rifampin (Rifadin®, Rifater ®, Rifamate®, Rimactane®), sildenafil (Revatio®) when used for pulmonary arterial hypertension (PAH), simvastatin or a product that contains simvastatin (Simcor,® Vytorin®, Zocor ®), St. John’s Wort (Hypericum perforatum) or a product that contains St. John’s Wort, or triazolam (Halcion®). • Serious problems can happen if you take any of these medicines with PREZCOBIX.® What are the possible side effects of PREZCOBIX®? PREZCOBIX® may cause serious side effects including: • Diabetes and high blood sugar • Changes in body fat can happen in people taking HIV-1 medications • Immune system changes (Immune Reconstitution Syndrome) can happen in people who start HIV-1 medications • Increased bleeding can occur in people with hemophilia who are taking PREZCOBIX.® The most common side effects are: • Diarrhea • Headache • Nausea • Stomach area (abdominal) pain • Rash • Vomiting These are not all of the possible side effects of PREZCOBIX®. For more information, ask your healthcare provider. What should I know about this Brief Summary? This information is not complete. To get more information: • Talk to your healthcare provider or pharmacist • Visit www.PREZCOBIX.com to read over the FDA-approved product labeling and patient information • Call to report side effects either to the FDA at 1-800-FDA-1088 or to Janssen Products, LP at 1-800-JANSSEN (1-800-526-7736). © Janssen Therapeutics, Division of Janssen Products, LP 2016 10/16 054195-160602
Here’s to settling down and never giving up.
Let’s Grow Old Together See what life with HIV looks like from diagnosis through grandkids with a little help from Walgreens. Meet Peter and Kathleen and hear their story at Walgreens.com/LetsGrowOldTogether. ©2017 Walgreen Co. All rights reserved.
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POZ.com
WEBSITE FEATURES INCLUDE: • Responsive design optimized for smartphones and tablets • Faster site for quicker load times • Redesigned for easier readability and navigation • Improved search function
Call for Nominations! Early Deadline: August st 25 5
8TH Annual
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Women N NG CELEBRATING
POZ is seeking nominations for the 2017 POZ 100. This year’s list will celebrate both women living with HIV and those who are HIV negative making a difference in the fight against HIV/AIDS S from fro across ross the country. Established ab sh in 20 2010, the POZ 100 recognizes s individuals vi als and a organizations zatio committed tted to o ending en g the he HIV/AIDS S epidemic. id
Don’t delay! Submit your nomination for the 2017 POZ 2017 POZ 100 100 today!
For more information fo mation and nd d tto submit a n nomination mination (self-nominations elff-nominations at are accepted a accepted), d go to POZ.com/nominate. P Z om/ te
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I am a devoted son, a singer, and an artist. And I am living with HIV.
Jamar has lived with HIV since 2006.
Get the facts. Get tested. Get involved. www.ActAgainstAIDS.org
WHAT IS GENVOYA®? GENVOYA is a 1-pill, once-a-day prescription medicine used to treat HIV-1 in people 12 years and older who weigh at least 77 pounds. It can either be used in people who are starting HIV-1 treatment and have never taken HIV-1 medicines before, or people who are replacing their current HIV-1 medicines and whose healthcare provider determines they meet certain requirements. These include having an undetectable viral load (less than 50 copies/mL) for 6 months or more on their current HIV-1 treatment. GENVOYA combines 4 medicines into 1 pill taken once a day with food. GENVOYA is a complete HIV-1 treatment and should not be used with other HIV-1 medicines. GENVOYA does not cure HIV-1 infection or AIDS. To control HIV-1 infection and decrease HIV-related illnesses, you must keep taking GENVOYA. Ask your healthcare provider if you have questions about how to reduce the risk of passing HIV-1 to others. Always practice safer sex and use condoms to lower the chance of sexual contact with body fluids. Never reuse or share needles or other items that have body fluids on them.
IMPORTANT SAFETY INFORMATION What is the most important information I should know about GENVOYA? GENVOYA may cause serious side effects: • Worsening of hepatitis B (HBV) infection. GENVOYA is not approved to treat HBV. If you have both HIV-1 and HBV and stop taking GENVOYA, your HBV may suddenly get worse. Do not stop taking GENVOYA without first talking to your healthcare provider, as they will need to monitor your health. Who should not take GENVOYA? Do not take GENVOYA if you take: • Certain prescription medicines for other conditions. It is important to ask your healthcare provider or pharmacist about medicines that should not be taken with GENVOYA. Do not start a new medicine without telling your healthcare provider. • The herbal supplement St. John’s wort. • Any other medicines to treat HIV-1 infection. What are the other possible side effects of GENVOYA? Serious side effects of GENVOYA may also include: • Changes in your immune system. Your immune system may get stronger and begin to fight infections. Tell your healthcare provider if you have any new symptoms after you start taking GENVOYA.
• Kidney problems, including kidney failure. Your healthcare provider should do blood and urine tests to check your kidneys. If you develop new or worse kidney problems, they may tell you to stop taking GENVOYA. • Too much lactic acid in your blood (lactic acidosis), which is a serious but rare medical emergency that can lead to death. Tell your healthcare provider right away if you get these symptoms: weakness or being more tired than usual, unusual muscle pain, being short of breath or fast breathing, stomach pain with nausea and vomiting, cold or blue hands and feet, feel dizzy or lightheaded, or a fast or abnormal heartbeat. • Severe liver problems, which in rare cases can lead to death. Tell your healthcare provider right away if you get these symptoms: skin or the white part of your eyes turns yellow, dark “tea-colored” urine, light-colored stools, loss of appetite for several days or longer, nausea, or stomach-area pain. The most common side effect of GENVOYA is nausea. Tell your healthcare provider if you have any side effects that bother you or don’t go away. What should I tell my healthcare provider before taking GENVOYA? • All your health problems. Be sure to tell your healthcare provider if you have or have had any kidney or liver problems, including hepatitis virus infection. • All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect how GENVOYA works. Keep a list of all your medicines and show it to your healthcare provider and pharmacist. Ask your healthcare provider if it is safe to take GENVOYA with all of your other medicines. • If you take antacids. Take antacids at least 2 hours before or after you take GENVOYA. • If you are pregnant or plan to become pregnant. It is not known if GENVOYA can harm your unborn baby. Tell your healthcare provider if you become pregnant while taking GENVOYA. • If you are breastfeeding (nursing) or plan to breastfeed. Do not breastfeed. HIV-1 can be passed to the baby in breast milk. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Please see Important Facts about GENVOYA, including important warnings, on the following page.
Ask your healthcare provider if GENVOYA is right for you. GENVOYA.com
GENVOYA does not cure HIV-1 or AIDS.
SHOW YOUR
POWER
Take care of what matters most—you. GENVOYA is a 1-pill, once-a-day complete HIV-1 treatment for people who are either new to treatment or people whose healthcare provider determines they can replace their current HIV-1 medicines with GENVOYA.
IMPORTANT FACTS WHAT IS GENVOYA®? GENVOYA is a 1-pill, once-a-day prescription medicine
( used ) in people 12 years and older who jen-VOY-uh to treat HIV-1
weigh at least 77 pounds. It can either be used in people who are starting HIV-1 treatment and have never taken MOST IMPORTANT INFORMATION ABOUT GENVOYA HIV-1 medicines before, or people who are replacing their current HIV-1 and side whose healthcare provider GENVOYA maymedicines cause serious effects, including: determines they meet certain requirements. These include • Worsening of hepatitis B (HBV) infection. GENVOYA is not having an undetectable viral load (less than 50 copies/mL) approved to treat HBV. If you have both HIV-1 and HBV, your for 6 months or more theirif current HBV may suddenly geton worse you stopHIV-1 takingtreatment. GENVOYA. GENVOYA combines 4 medicines into pill taken once a Do not stop taking GENVOYA without first1talking to your day with food. GENVOYA a complete HIV-1 treatment healthcare provider, as theyiswill need to check your health regularly fornot several months. and should be used with other HIV-1 medicines. GENVOYA does not cure HIV-1 infection or AIDS. ABOUT GENVOYA To control HIV-1 infection and decrease HIV-related illnesses, you must keep taking GENVOYA. Ask your • GENVOYA is a prescription medicine used to treat HIV-1 in healthcare provider if you have questions about how 12 years of age and older HIV-1 who weigh at leastAlways 77 pounds topeople reduce the risk of passing to others. and have never taken HIV-1 medicines before. GENVOYA can practice safer sex and use condoms to lower the chance also be used to replace current HIV-1 medicines for some ofpeople sexual contact with body fluids. reuse who have an undetectable viralNever load (less thanor 50share needles or other items that have body fluids on them. copies/mL of virus in their blood), and have been on the same HIV-1 medicines for at least 6 months and have never failed IMPORTANT SAFETY INFORMATION HIV-1 treatment, and whose healthcare provider determines that they meet certain other requirements. What is the most important information I should
•know GENVOYA does not cure HIV-1 or AIDS. Ask your healthcare about GENVOYA?
provider about how to prevent passing HIV-1 to others.
GENVOYA may cause serious side effects: Do NOT take GENVOYA if you:B (HBV) infection. GENVOYA • Worsening of hepatitis ® • Take a medicine thattocontains: alfuzosin ), HIV-1 is not approved treat HBV. If you(Uroxatral have both ® ® ® carbamazepine (Carbatrol , Epitol , Equetro , Tegretol , and HBV and stop taking GENVOYA, your HBV ®may ® ® Tegretol-XR , Teril ), cisapride (Propulsid , Propulsid suddenly ®get worse. Do not stop taking GENVOYA Quicksolv ), dihydroergotamine (D.H.E. 45®, Migranal without ®first talking to your healthcare provider,®),as they ® ® ergotamine (Cafergot , Migergot , Ergostat®, Medihaler will need to monitor your health. Ergotamine®, Wigraine®, Wigrettes®), lovastatin (Advicor®,
® ® Altoprev , Mevacor ), lurasidone (Latuda®), methylergonovine Who should not take GENVOYA?
(Ergotrate®, Methergine®), midazolam (when taken by mouth),
Do not take GENVOYA if you take: phenobarbital (Luminal®), phenytoin (Dilantin®, Phenytek®), Certain(Orap prescription for other conditions. •pimozide ® ® ® ), rifampinmedicines (Rifadin®, Rifamate , Rifater , It is important to askwhen yourused healthcare provider or ® Rimactane ), sildenafil for lung problems pharmacist about medicines that should be taken ® ® ® (Revatio ), simvastatin (Simcor®, Vytorin , Zocornot ), or with GENVOYA. triazolam (Halcion®).Do not start a new medicine without telling your healthcare provider. • Take the herbal supplement St. John’s wort. • The herbal supplement St. John’s wort. • Take any other HIV-1 medicines at the same time. • Any other medicines to treat HIV-1 infection. What are the other possible side effects GET MORE INFORMATION of GENVOYA? side effects of GENVOYA may also include: •Serious This is only a brief summary of important information about
Changes in your immune system. Yourorimmune •GENVOYA. Talk to your healthcare provider pharmacist may get stronger and begin to fight infections. tosystem learn more. Telltoyour healthcare or provider if you have any new • Go GENVOYA.com call 1-800-GILEAD-5 symptoms after you start taking GENVOYA. •
If you need help paying for your medicine, visit GENVOYA. com for program information.
This is only a brief summary of important information about GENVOYA® and does not replace talking to your healthcare provider including kidneyabout failure.your Your problems, • Kidney and your treatment. condition healthcare provider should do blood and urine tests to
check your kidneys. If you develop new or worse kidney problems, they may tell you to stop taking GENVOYA. SIDE acid EFFECTS OF GENVOYA Too much lactic in your blood (lactic acidosis), •POSSIBLE which is a serious but rare medical emergency that can GENVOYA can cause serious side effects, including: lead to death. Tell your healthcare provider right away if •you Those the “Most Important Information Aboutmore tired getinthese symptoms: weakness or being GENVOYA” section.muscle pain, being short of breath or than usual, unusual breathing, stomach with nausea and vomiting, •fast Changes in your immunepain system. cold or blue hands and feet, feel dizzy orkidney lightheaded, • New or worse kidney problems, including failure. or a fast or abnormal heartbeat. • Too much lactic acid in your blood (lactic acidosis), which • Severe liver problems, which in rare cases can is a serious but rare emergencyprovider that can lead to lead to death. Tell medical your healthcare right death. provider right away if you get these away if Tell youyour gethealthcare these symptoms: skin or the white symptoms: or yellow, being more tired than usual, unusual part of yourweakness eyes turns dark “tea-colored” muscle pain, being short of breath fast breathing, stomach urine, light-colored stools, loss oforappetite for several pain or with nauseanausea, and vomiting, cold or blue hands days longer, or stomach-area pain.and feet, dizzycommon or lightheaded, a fastof or GENVOYA abnormal heartbeat. is nausea. Thefeel most side or effect • Severe Tell your healthcare provider if you have any sidetoeffects liver problems, which in rare cases can lead death. thatTell bother you or don’t go away. your healthcare provider right away if you get these symptoms: skin or the white part of your eyes turns yellow,
What I tell my healthcare provider before darkshould “tea-colored” urine, light-colored stools, loss of appetite taking GENVOYA? for several days or longer, nausea, or stomach-area pain. All most your common health problems. Beofsure to tell your •The side effect GENVOYA is nausea. healthcare provider if you have or have had any kidney These are not all the possible side effects of GENVOYA. or liver problems, including hepatitis virus infection. Tell your healthcare provider right away if you have any new •symptoms All the medicines take, including prescription while takingyou GENVOYA. and over-the-counter medicines, vitamins, and herbal Your healthcareOther provider will needmay to doaffect testshow to monitor supplements. medicines your health before during with GENVOYA. GENVOYA works.and Keep a listtreatment of all your medicines and show it to your healthcare provider and pharmacist. Ask your healthcare provider if it is safe to take BEFORE TAKING GENVOYA GENVOYA with all of your other medicines. If you take antacids. Take antacids •Tell your healthcare provider if you: at least 2 hours before or after you take GENVOYA. • Have or have had any kidney or liver problems, including you areinfection. pregnant or plan to become pregnant. It is • Ifhepatitis not known if GENVOYA can harm your unborn baby. • Have any other medical condition. Tell your healthcare provider if you become pregnant •while Are pregnant or plan to become pregnant. taking GENVOYA. breastfeeding (nursing) (nursing) or plan to or breastfeed. you are breastfeeding plan to Do not • •IfAre breastfeed ifDo younot have HIV-1 because the risk of passing breastfeed. breastfeed. HIV-1ofcan be passed to yourinbaby. toHIV-1 the baby breast milk. Tellare your healthcare to provider all the medicines You encouraged reportabout negative side you take: effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, call 1-800-FDA-1088. • Keep a list that includes all or prescription and over-thecounter medicines, vitamins, and herbal supplements, and
Please Facts about and GENVOYA, showsee it toImportant your healthcare provider pharmacist. including important warnings, on the following • Ask your healthcare provider or pharmacist about page. medicines that should not be taken with GENVOYA.
HOW TO TAKE GENVOYA
• GENVOYA is a complete one pill, once a day HIV-1 medicine. Ask your healthcare provider if GENVOYA is right for you. • Take GENVOYA with food.
GENVOYA.com
GENVOYA, the GENVOYA Logo, LOVE WHAT’S INSIDE, SHOW YOUR POWER, GILEAD, and the GILEAD Logo are trademarks of Gilead Sciences, Inc., or its related companies. All other marks referenced herein are the property of their respective owners. Version date: April 2017 © 2017 Gilead Sciences, Inc. All rights reserved. GENC0141 04/17
YOU MATTER AND SO DOES YOUR HEALTH
That’s why starting and staying on HIV-1 treatment is so important.
WHAT IS DESCOVY®?
DESCOVY is a prescription medicine that is used together with other HIV-1 medicines to treat HIV-1 in people 12 years and older. DESCOVY is not for use to help reduce the risk of getting HIV-1 infection. DESCOVY combines 2 medicines into 1 pill taken once a day. Because DESCOVY by itself is not a complete treatment for HIV-1, it must be used together with other HIV-1 medicines.
DESCOVY does not cure HIV-1 infection or AIDS. To control HIV-1 infection and decrease HIV-related illnesses, you must keep taking DESCOVY. Ask your healthcare provider if you have questions about how to reduce the risk of passing HIV-1 to others. Always practice safer sex and use condoms to lower the chance of sexual contact with body fluids. Never reuse or share needles or other items that have body fluids on them.
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about DESCOVY? DESCOVY may cause serious side effects: • Worsening of hepatitis B (HBV) infection. DESCOVY is not approved to treat HBV. If you have both HIV-1 and HBV and stop taking DESCOVY, your HBV may suddenly get worse. Do not stop taking DESCOVY without first talking to your healthcare provider, as they will need to monitor your health. What are the other possible side effects of DESCOVY? Serious side effects of DESCOVY may also include: • Changes in your immune system. Your immune system may get stronger and begin to fight infections. Tell your healthcare provider if you have any new symptoms after you start taking DESCOVY. • Kidney problems, including kidney failure. Your healthcare provider should do blood and urine tests to check your kidneys. Your healthcare provider may tell you to stop taking DESCOVY if you develop new or worse kidney problems. • Too much lactic acid in your blood (lactic acidosis), which is a serious but rare medical emergency that can lead to death. Tell your healthcare provider right away if you get these symptoms: weakness or being
more tired than usual, unusual muscle pain, being short of breath or fast breathing, stomach pain with nausea and vomiting, cold or blue hands and feet, feel dizzy or lightheaded, or a fast or abnormal heartbeat. • Severe liver problems, which in rare cases can lead to death. Tell your healthcare provider right away if you get these symptoms: skin or the white part of your eyes turns yellow, dark “tea-colored” urine, light-colored stools, loss of appetite for several days or longer, nausea, or stomach-area pain. • Bone problems, such as bone pain, softening, or thinning, which may lead to fractures. Your healthcare provider may do tests to check your bones. The most common side effect of DESCOVY is nausea. Tell your healthcare provider if you have any side effects that bother you or don’t go away. What should I tell my healthcare provider before taking DESCOVY? • All your health problems. Be sure to tell your healthcare provider if you have or have had any kidney, bone, or liver problems, including hepatitis virus infection. • All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect how DESCOVY works. Keep a list of all your medicines and show it to your healthcare provider and pharmacist. Ask your healthcare provider if it is safe to take DESCOVY with all of your other medicines. • If you are pregnant or plan to become pregnant. It is not known if DESCOVY can harm your unborn baby. Tell your healthcare provider if you become pregnant while taking DESCOVY. • If you are breastfeeding (nursing) or plan to breastfeed. Do not breastfeed. HIV-1 can be passed to the baby in breast milk. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Please see Important Facts about DESCOVY, including important warnings, on the following page.
Ask your healthcare provider if an HIV-1 treatment that contains DESCOVY® is right for you.
IMPORTANT FACTS This is only a brief summary of important information about DESCOVY and does not replace talking to your healthcare provider about your condition and your treatment. ®
(des-KOH-vee) MOST IMPORTANT INFORMATION ABOUT DESCOVY
POSSIBLE SIDE EFFECTS OF DESCOVY
DESCOVY may cause serious side effects, including: • Worsening of hepatitis B (HBV) infection. DESCOVY is not approved to treat HBV. If you have both HIV-1 and HBV, your HBV may suddenly get worse if you stop taking DESCOVY. Do not stop taking DESCOVY without first talking to your healthcare provider, as they will need to check your health regularly for several months.
DESCOVY can cause serious side effects, including: • Those in the “Most Important Information About DESCOVY” section. • Changes in your immune system. • New or worse kidney problems, including kidney failure. • Too much lactic acid in your blood (lactic acidosis), which is a serious but rare medical emergency that can lead to death. Tell your healthcare provider right away if you get these symptoms: weakness or being more tired than usual, unusual muscle pain, being short of breath or fast breathing, stomach pain with nausea and vomiting, cold or blue hands and feet, feel dizzy or lightheaded, or a fast or abnormal heartbeat. • Severe liver problems, which in rare cases can lead to death. Tell your healthcare provider right away if you get these symptoms: skin or the white part of your eyes turns yellow, dark “tea-colored” urine, light-colored stools, loss of appetite for several days or longer, nausea, or stomach-area pain. • Bone problems. The most common side effect of DESCOVY is nausea. These are not all the possible side effects of DESCOVY. Tell your healthcare provider right away if you have any new symptoms while taking DESCOVY. Your healthcare provider will need to do tests to monitor your health before and during treatment with DESCOVY.
ABOUT DESCOVY • DESCOVY is a prescription medicine that is used together with other HIV-1 medicines to treat HIV-1 in people 12 years of age and older. DESCOVY is not for use to help reduce the risk of getting HIV-1 infection. • DESCOVY does not cure HIV-1 or AIDS. Ask your healthcare provider about how to prevent passing HIV-1 to others.
BEFORE TAKING DESCOVY Tell your healthcare provider if you: • Have or had any kidney, bone, or liver problems, including hepatitis infection. • Have any other medical condition. • Are pregnant or plan to become pregnant. • Are breastfeeding (nursing) or plan to breastfeed. Do not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby. Tell your healthcare provider about all the medicines you take: • K eep a list that includes all prescription and over-the-counter medicines, vitamins, and herbal supplements, and show it to your healthcare provider and pharmacist. • Ask your healthcare provider or pharmacist about medicines that should not be taken with DESCOVY.
GET MORE INFORMATION • This is only a brief summary of important information about DESCOVY. Talk to your healthcare provider or pharmacist to learn more. • Go to DESCOVY.com or call 1-800-GILEAD-5 • If you need help paying for your medicine, visit DESCOVY.com for program information.
HOW TO TAKE DESCOVY • DESCOVY is a one pill, once a day HIV-1 medicine that is taken with other HIV-1 medicines. • Take DESCOVY with or without food. DESCOVY, the DESCOVY Logo, LOVE WHAT’S INSIDE, GILEAD, and the GILEAD Logo are trademarks of Gilead Sciences, Inc., or its related companies. All other marks referenced herein are the property of their respective owners. Version date: April 2017 © 2017 Gilead Sciences, Inc. All rights reserved. DVYC0057 05/17
STOPPING THE VIRUS CAN START WITH YOU. Here are two resources that can help.
Watch videos, share information, and see how we can all help stop the virus. HelpStopTheVirus.com YouTube.com/HelpStopTheVirus
Get the answers you need, privately, on your phone. HIVanswers.com/app
© 2016 Gilead Sciences, Inc. All rights reserved. UNBC3359 06/16
H E A L T H ,
L I F E
&
H I V
Antiretroviral (ARV) options abound for both those who are new to HIV treatment and those who are experienced. This quick-reference chart compares available medication options, including adult dosing and dietary restrictions. *Generic version available in the U.S.
COMBIVIR *
APTIVUS
(zidovudine + lamivudine) One tablet twice a day. Each tablet contains 300 mg zidovudine + 150 mg lamivudine. Take with or without food.
One tablet once a day. Each tablet contains 600 mg efavirenz + 300 mg tenofovir disoproxil + 200 mg emtricitabine. Take on an empty stomach. Dose should be taken at bedtime to minimize dizziness, drowsiness and impaired concentration.
(tenofovir alafenamide + emtricitabine)
CRIXIVAN (indinavir)
One tablet once a day. Each tablet contains 25 mg tenofovir alafenamide + 200 mg emtricitabine. Take with or without food.
Two 400 mg capsules every eight hours, or two 400 mg capsules with either one or two 100 mg Norvir tablets (or capsules) twice a day. Drink at least 48 ounces of water daily to prevent kidney stones. Without Norvir: Take on an empty stomach (no food two hours before or one hour after dosing) or with a low-fat snack. With Norvir: Take with or without food.
COMPLERA
EMTRIVA
(emtricitabine)
One tablet once a day. Each tablet contains 25 mg rilpivirine + 300 mg tenofovir disoproxil + 200 mg emtricitabine. Take with a meal.
One 200 mg capsule once a day. Take with or without food.
EVOTAZ
(atazanavir + cobicistat)
EPIVIR *
One tablet once a day. Each tablet contains 150 mg elvitegravir + 150 mg cobicistat + 10 mg tenofovir alafenamide + 200 mg emtricitabine. Take with food.
ODEFSEY
(rilpivirine + tenofovir alafenamide + emtricitabine) One tablet once a day. Each tablet contains 25 mg rilpivirine + 25 mg tenofovir alafenamide + 200 mg emtricitabine. Take with a meal.
STRIBILD
(elvitegravir + cobicistat + tenofovir disoproxil + emtricitabine) One tablet once a day. Each tablet contains 150 mg elvitegravir + 150 mg cobicistat + 300 mg tenofovir disoproxil + 200 mg emtricitabine. Take with food.
One tablet once a day. Each tablet contains 300 mg atazanavir + 150 mg cobicistat. Take with food.
One 300 mg tablet once a day, or one 150 mg tablet twice a day. Take with or without food. Also approved for the treatment of hepatitis B virus (HBV) but at a lower dose. People living with both viruses should use the HIV dose.
INVIRASE
(saquinavir) Two 500 mg tablets plus one 100 mg Norvir tablet (or capsule) twice a day. Take with food or within two hours after a meal.
EPZICOM *
(abacavir + lamivudine) One tablet once a day. Each tablet contains 600 mg abacavir + 300 mg lamivudine. Take with or without food. Should be used only by individuals who are HLA-B*5701 negative.
One 25 mg tablet once a day. Take with food.
(zidovudine)
One 300 mg tablet twice a day. Take with or without food.
TRIZIVIR
(abacavir + zidovudine + lamivudine) One tablet twice a day. Each tablet contains 300 mg abacavir + 300 mg zidovudine + 150 mg lamivudine. Take with or without food. Should be used only by individuals who are HLA-B*5701 negative.
(etravirine)
One 200 mg tablet twice a day. Take with food.
RESCRIPTOR (delavirdine)
Two 200 mg tablets three times a day, or four 100 mg tablets three times a day. Take with or without food. Discontinued by manufacturer; phaseout to be completed by 2020.
SUSTIVA
(efavirenz) One 600 mg tablet once a day, or three 200 mg capsules once a day. Take on an empty stomach or with a low-fat snack. Dose should be taken at bedtime to minimize dizziness, drowsiness and impaired concentration.
(nevirapine)
One 200 mg Viramune immediate release (IR) tablet once a day for the first 14 days, then one 400 mg Viramune extended release (XR) tablet once a day. Take with or without food.
KALETRA
(lopinavir + ritonavir)
RETROVIR *
INTELENCE
VIRAMUNE *
Protease Inhibitors (PIs)
Single-Tablet Regimens
(elvitegravir + cobicistat + tenofovir alafenamide + emtricitabine)
Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs, or nukes)
(lamivudine)
GENVOYA
(rilpivirine)
Two 250 mg capsules plus two 100 mg Norvir tablets (or capsules) twice a day. Aptivus plus Norvir should be taken with food. Aptivus plus Norvir should not be taken with other protease inhibitors.
DESCOVY
(rilpivirine + tenofovir disoproxil + emtricitabine)
EDURANT
(tipranavir)
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs, or non-nukes)
(efavirenz + tenofovir disoproxil + emtricitabine)
Two tablets twice a day, or four tablets once a day, depending on HIV drug resistance. Each tablet contains 200 mg lopinavir + 50 mg ritonavir. Take with or without food.
LEXIVA
(fosamprenavir) Two 700 mg tablets twice a day, or two 700 mg tablets plus one or two Norvir tablets once a day, or one 700 mg tablet plus one Norvir tablet twice a day (recommended for individuals who have used other PIs in the past). Take with or without food.
Entry Inhibitors
ATRIPLA
Pills not shown actual size
FUZEON
(enfuvirtide) One 90 mg (1 ml solution) subcutaneous injection twice a day. Take with or without food. Fuzeon comes as a white powder that must be mixed with sterile water in a vial each day.
TRUVADA TRIUMEQ
(dolutegravir + abacavir + lamivudine) One tablet once a day. Each tablet contains 50 mg dolutegravir + 600 mg abacavir + 300 mg lamivudine. Take with or without food. Should be used only by individuals who are HLA-B*5701 negative.
(tenofovir disoproxil + emtricitabine) One tablet once a day. Each tablet contains 300 mg tenofovir disoproxil + 200 mg emtricitabine. Take with or without food.
NORVIR
(ritonavir)
SELZENTRY
Six 100 mg tablets twice a day. The full dose of Norvir is rarely used. It is most often used at lower doses to boost the levels of other ARVs in the blood. Take with food.
One 150 mg, 300 mg or 600 mg tablet twice a day, depending on other meds used. Take with or without food.
(maraviroc)
VIDEX EC *
(didanosine)
ISENTRESS
Integrase Inhibitors
(raltegravir)
Two 600 mg (HD) tablets once a day for those who are treatment naive or whose virus has been suppressed on an initial regimen of twice-daily Isentress, or one 400 mg tablet twice a day. Take with or without food.
(tenofovir disoproxil)
TIVICAY
One 50 mg tablet once a day for those first starting ARV therapy or for those who have not used an integrase inhibitor in the past. One 50 mg tablet twice a day for treatment-experienced individuals who have HIV that is resistant to other integrase inhibitors and when taken with certain ARVs. Take with or without food.
PREZCOBIX
(darunavir + cobicistat) One tablet once a day. Each tablet contains 800 mg darunavir + 150 mg cobicistat. Take with food.
PREZISTA (darunavir)
VIREAD (dolutegravir)
PK Enhancer
One 400 mg capsule once a day. (One 250 mg capsule once a day for those weighing less than 133 lbs.) Take on an empty stomach (two hours after or one hour before a meal). Videx EC should be taken with water. It should not be taken with acidic juices, soda or milk. Videx EC should be taken at least two hours after or two hours before Aptivus or Reyataz. Avoid alcohol. Discontinued by manufacturer; phaseout to be completed by 2020. Generic version will remain available.
One 300 mg tablet once a day. Take with or without food.
ZERIT *
(stavudine) One 40 mg capsule twice a day. (One 30 mg capsule twice a day for those weighing less than 133 lbs.) Take with or without food. Discontinued by manufacturer; phaseout to be completed by 2020. Generic version will remain available.
One 800 mg tablet (or two 400 mg tablets) plus one 100 mg Norvir tablet or one 150 mg Tybost tablet once a day, or one 600 mg tablet plus one 100 mg Norvir tablet twice a day, depending on drug resistance. Take with food.
REYATAZ
(atazanavir) Two 200 mg capsules once a day, or one 300 mg capsule plus one 100 mg Norvir tablet or one 150 mg Tybost tablet once a day. Take with food.
TYBOST
ZIAGEN * (abacavir)
VIRACEPT
One 150 mg tablet once a day in combination with ARVs that require boosting. Used only to boost other drugs. Take with food.
One 300 mg tablet twice a day, or two 300 mg tablets once a day. Take with or without food. Should be used only by individuals who are HLA-B*5701 negative.
Two 625 mg tablets twice a day, or five 250 mg tablets twice a day, or three 250 mg tablets three times a day. Take with food.
(cobicistat)
(nelfinavir)
When choosing your HIV regimen, be sure to ask your doctor about: Potency: Is the combo powerful enough to keep my viral load undetectable? Safety: What are the short- and long-term side effects of the meds? Convenience: How many pills must I take and how many times a day? Interactions: How do the meds work with other drugs I’m taking?
To learn more about these medications, including possible side effects and drug interactions, visit POZ.com.
A HEALTHIER LIFE CAN START WITH HIV TREATMENT. Starting HIV treatment right after diagnosis can help stop the virus in your body. Because treatment helps lower the damage HIV causes to your immune system. Plus, doctors and scientists have found that it can help lower the risk of heart disease and certain cancers.
TREATMENT ALSO HELPS YOU PROTECT OTHERS. HIV treatment can help lower the amount of virus in your body. It can get so low, it can’t be measured by a test. It’s called being undetectable. And it helps lower the chance of passing HIV on to others by more than 90%.
STOPPING T CAN START
Here are two resour
Watch videos, share see how we can all h
HelpStopThe
TALK TO YOUR HEALTHCARE PROVIDER.
YouTube.com/Hel
Have an open conversation. When you work together it helps your healthcare provider find the treatment that’s right for you.
Get the answe privately, on y
Watch HIV: “Treat 2 Prevent”
HIVanswers
See how staying on treatment can help protect you and the people you care about. YouTube.com/HelpStopTheVirus
© 2016 Gilead Scienc Scien
THE VIRUS WITH YOU.
START HIV TREATMENT. HELP PROTECT YOUR HEALTH.
rces that can help.
e information, and help stop the virus.
eVirus.com
lpStopTheVirus
ers you need, your phone.
There is no cure for HIV, but find out how treatment helps make it possible to live a healthy life.
s.com/app
ces, Inc. All rights reserved. UNBC3359 06/16 nces,
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