Transactions on Engineering and Sciences Vol.3, Issue 2, February 2015
ISSN: 2347-1964 (Online) 2347-1875 (Print)
Synthesis, Physico -Chemical and Antimicrobial Properties of n(II),Fe(II),Co(II),Ni(II),Cu(II),Zn(II) and Cd (II), Mixed Ligand Complexes of cephalexin mono hydrate (antibiotics) and Furan-2-carboxylic acid Taghreed . Hashim Al-Noor1 1,2&3 Department
Faiza. H Ghanim2
Bassim Abd Shahoobi3
of Chemistry .Ibn -Al-Haithem College of Education for pure science, University of Baghdad, Baghdad, Iraq.
Abstract— A series of new mixed ligand complexes of Mn(II),Fe(II),Co(II),Ni(II),Cu(II),Zn(II) and Cd (II) have been synthesized with cephalexin mono hydrate ( CephH) = ( C16H19N3O5S.H2O) and Furan-2-carboxylic acid(FCA H) =( C5H4O3) .The mixed ligand complexes have been repeated
melting
point
determination,
spectroscopic
spectral
UV-Vis.),molar conductance, magnetic susceptibility measurements and determination of
the metal
in
the
complexes
by
flame(AAS). The
characterized by
measurements
(FT-IR,
the percentage
ligands and their metal complexes were
screened for their antimicrobial activity against four bacteria (gram + ve) and (gram -ve).The proposed structure of the complexes using program, Chem office 3D (2006) . The general formula have been given for the prepared
mixed ligand complexesNa2[M(FCA)3(Ceph)], M(II) = Mn (II) , Fe
(II),Co(II) ,Ni(II),Cu (II), Zn(II) , and Cd(II). Index Terms— Cephalexin antibiotics, Furan 2-carboxylic acid, drugs mixed ligand complexes, and antibacterial activities. I. INTRODUCTION Bioactive donor site of ( N,S/O) atoms in organic ligand moieties were widely used in the development of metal based drugs, analytical, industrial, medicinal, agricultural, biological and clinical areas. [1-2]. Many drugs possess modified toxicological and pharmacological properties when they are in the form of metal complexes. The most widely studied metal in this respect is copper(II) which has proved beneficial in diseases such as tuberculosis, gastric ulcers, rheumatoid arthritis and cancers. [3].The coordination chemistry of some beta-lactam antibiotics with transition and d10 metal ions has been reported [4-8]. Furan-2-carboxylic acid( C5H4O3) (FCAH) is a heterocyclic aromatic compound with five- membered ring structure consisting of four CH2 groups, one oxygen atom and a carboxylic group. [9].Synthesis and identification of type mixed ligand complexes of
M+2
Ions using Furan-2-carboxylic acid as a primary
ligand and 1,10-phenanthroline (phen )as secondary ligand has been reported. [10]. Literature survey shows that no studies on the synthesis and characterization of mixed ligand complexes of Furan-2-carboxylic acid and cephalexin (antibiotics) have been reported. In this paper we present the synthesis and study of Mn(II),Fe(II),Co(II),Ni(II), Cu(II),Zn(II), and Cd(II) complexes with cephalexin mono hydrate (antibiotics) as a primary ligand and
Furan-2-carboxylic acid
as secondary ligand. II. EXPERIMENTAL A. Chemicals : All chemical reagents and solvents used were of analytical grade and were used without further
purification
and
were
used
as
received
1
MnCl2.2H2O,
FeCl2.9H2O,CoCl2.6H2O,
Techscripts