Advanced sensor and diagnostic technologies: Diagnostic

Diagnostic

ADVANCED SENSOR AND DIAGNOSTIC TECHNOLOGIES

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DIAGNOSTIC by tecnalia

ADVANCED SENSOR AND DIAGNOSTIC TECHNOLOGIES

CHEMICALLY MODIFIED POLYSTYRENE SURFACE

CONCEPT

SERVICES

Surface modification of PS by means of introduction of various functional groups such as amine, carboxylic, thiols, cyclooctins, alkenes, epoxy chlorosulphonyl allowing the control of surface chemical properties, the surface density of functional groups and their proximity to the surface.

→→ Screening of biomolecules immobilization process on different surface chemistries. →→ Design and development of LOC based on functionalized polystyrene. →→ Sensitivity improvement studies of conventional immunoassays.

APPLICATIONS Advanced and affordable diagnostic polystyrene devices based on Lab On a Chip, biosensing microarrays and functionalised multi well plates that require immobilization of biomolecules.

Glass Slide

Amina

PROTEIN CHIP. Assays performed by courtesy of IMG Pharma.

ADVANTAGES →→ Improved modified polystyrene stability over time without special storage conditions. →→ Preserved polystyrene optical properties. →→ Improved detection limit of conventional diagnostic assays.

Glass Slide

Amino

CELL MEMBRANE CHIP. Assays performed by courtesy of IMG Pharma.

IMMUNOASSAYS. (Elisa sandwich type, indirect, direct)

TECNALIA INSPIRING BUSINESS

INTEGRATION OF BIOMEDICAL ELECTRODES FOR ELECTROCHEMICAL DETECTION AND ELECTROSTIMULATION →→ Microarrays and micropatterned biofunctionalized electrodes on polystyrene. →→ Bioelectrochemical detection assays. →→ Electrophysiological stimulation and detection.

SENSORIZATION OF BIOMEDICAL DEVICES →→ Electrochemical sensors for monitoring of biomarkers, performance and maturation of biomedical materials and devices.

PRINCIPAL PROJECTS →→ R2R-Biofluidics: process of roll-to-roll manufacturing of surfaces for controlled neuronal growth (H2020-NMPPILOTS-2014, 2015-2019). →→ Immunosurfaces for SPR. →→ Lectin-arrays on polystyrene and biosensors.

Micropatterned and biofuncionalized printed electrodes on polymeric substrates.

METHODS OF DETECTION AND DEVICES BASED ON FLUORESCENCE (INTENSITY, FRET AND POLARIZED FLUORESCENCE) →→ Detection of proteins, microorganisms. →→ Drug screening.

PRINTABLE BIOINKS →→ Biofunctionalized inks. →→ Printed microfluidics. →→ Immunoassays.

→→ Supranano Quantum Dots based detection for development of electrochemical immunosensor. →→ Detection methods based on FRET and polarized fluorescence for biomaker detection and drug screening. →→ Cell differentiation by in vitro electrostimulation for bone diseases.

TECNALIA IS AN APPLIED RESEARCH AND TECHNOLOGICAL DEVELOPMENT CENTRE UNIVERSITIES AND PUBLIC RESEARCH CENTRES

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WE CAN DO SO MUCH TOGETHER Our work cannot be understood without yours; we would like to work together so your company can compete better. Because together, we can develop technologies which will transform the present.

The future is technological, let’s share it!

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Diagnostic

Contacts: GORAN BIJELIC goran.bijelic@tecnalia.com

NEREA BRIZ nerea.briz@tecnalia.com