Diagnostic
ADVANCED SENSOR AND DIAGNOSTIC TECHNOLOGIES
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DIAGNOSTIC by tecnalia
ADVANCED SENSOR AND DIAGNOSTIC TECHNOLOGIES
CHEMICALLY MODIFIED POLYSTYRENE SURFACE
CONCEPT
SERVICES
Surface modification of PS by means of introduction of various functional groups such as amine, carboxylic, thiols, cyclooctins, alkenes, epoxy chlorosulphonyl allowing the control of surface chemical properties, the surface density of functional groups and their proximity to the surface.
→→ Screening of biomolecules immobilization process on different surface chemistries. →→ Design and development of LOC based on functionalized polystyrene. →→ Sensitivity improvement studies of conventional immunoassays.
APPLICATIONS Advanced and affordable diagnostic polystyrene devices based on Lab On a Chip, biosensing microarrays and functionalised multi well plates that require immobilization of biomolecules.
Glass Slide
Amina
PROTEIN CHIP. Assays performed by courtesy of IMG Pharma.
ADVANTAGES →→ Improved modified polystyrene stability over time without special storage conditions. →→ Preserved polystyrene optical properties. →→ Improved detection limit of conventional diagnostic assays.
Glass Slide
Amino
CELL MEMBRANE CHIP. Assays performed by courtesy of IMG Pharma.
IMMUNOASSAYS. (Elisa sandwich type, indirect, direct)
TECNALIA INSPIRING BUSINESS
INTEGRATION OF BIOMEDICAL ELECTRODES FOR ELECTROCHEMICAL DETECTION AND ELECTROSTIMULATION →→ Microarrays and micropatterned biofunctionalized electrodes on polystyrene. →→ Bioelectrochemical detection assays. →→ Electrophysiological stimulation and detection.
SENSORIZATION OF BIOMEDICAL DEVICES →→ Electrochemical sensors for monitoring of biomarkers, performance and maturation of biomedical materials and devices.
PRINCIPAL PROJECTS →→ R2R-Biofluidics: process of roll-to-roll manufacturing of surfaces for controlled neuronal growth (H2020-NMPPILOTS-2014, 2015-2019). →→ Immunosurfaces for SPR. →→ Lectin-arrays on polystyrene and biosensors.
Micropatterned and biofuncionalized printed electrodes on polymeric substrates.
METHODS OF DETECTION AND DEVICES BASED ON FLUORESCENCE (INTENSITY, FRET AND POLARIZED FLUORESCENCE) →→ Detection of proteins, microorganisms. →→ Drug screening.
PRINTABLE BIOINKS →→ Biofunctionalized inks. →→ Printed microfluidics. →→ Immunoassays.
→→ Supranano Quantum Dots based detection for development of electrochemical immunosensor. →→ Detection methods based on FRET and polarized fluorescence for biomaker detection and drug screening. →→ Cell differentiation by in vitro electrostimulation for bone diseases.
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Diagnostic
Contacts: GORAN BIJELIC goran.bijelic@tecnalia.com NEREA BRIZ nerea.briz@tecnalia.com