Advanced biomaterials for regenerative medicine

ADVANCED BIOMATERIALS FOR REGENERATIVE MEDICINE

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ADVANCED BIOMATERIALS FOR REGENERATIVE MEDICINE

Fatrix WHAT IS IT? FATRIX is natural extracellular matrix processed from ex vivo human and animal adipose tissue.

FATRIX applications: →→ Tissue reconstruction and regeneration, mainly subcutaneous adipose tissue. →→ In vitro cell models: microtissues and organoids. →→ Biological components for in vitro diagnostic devices.

HOW DOES IT WORK? A new organic solvent-free method of enzymatic tissue decellularisation which removes cellular and immunological rejection components while preserving the natural extracellular matrix (ECM).

Made of proteins from adipose tissue ECM, rich in basement membrane proteins. →→ FATRIX mimics the microenvironment of tissues. →→ FATRIX boosts interaction with cell surface. →→ FATRIX promotes post implantation constructive tissue remodeling.

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PRODUCT DIFFERENTIATION →→ Human rich-on-protein basement membrane. →→ Homologous biological matrix providing subcutaneous adipose tissue microenvironment to facilitate its regeneration. →→ Inexpensive process and base ex vivo material. →→ Easy to scale up in production with process customisation.

HOMOLOGOUS BIOLOGICAL MATRIX PROVIDING SUBCUTANEOUS ADIPOSE TISSUE MICROENVIRONMENT TO FACILITATE ITS REGENERATION.

ADVANCED BIOMATERIALS FOR REGENERATIVE MEDICINE

Osteopeek WHAT IS IT? OSTEOPEEK is a porous and biofunctionalised PEEK that improves implant osseointegration. Currently, PEEK is the most commonly used material for manufacture of intersomatic cages for solving the problems of degeneration of vertebral discs.

WHAT FOR? To be used in intersomatic cages and osteosynthesis devices such as interference screws.

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PRODUCT DIFFERENTIATION The competitive advantage of OSTEOPEEK propietary technology enables to process PEEK with porous and control surface activity for a product with improved one integration.

POROUS AND BIOFUNCTIONALISED PEEK THAT IMPROVES OSSEOINTEGRATION.

→→ Chemically active surface. →→ Tailor-made mechanical properties. →→ Biocompatible.

ADVANCED BIOMATERIALS FOR REGENERATIVE MEDICINE

PorousPE WHAT IS IT? Ultra-high-molecular-weight polyethylene, also known as UHMWPE, is the polymeric material most frequently used in joint prostheses due to its high impact and fatigue resistance, as well as excellent biocompatibility. Nevertheless, its low osseointegration capacity requires the use of additional treatments and components.

UHMWPE foam aims to promote cell response improving prosthesis osseointegration thanks to its multimode porous structure preventing prosthesis failure while reducing recovery time.

This technology enables the application of UHMWPE foam on a dense part as if it was a coating.

WHAT FOR →→ Joint Prosthesis components for joint and ligament reconstruction. →→ Spinal Implants. →→ Oral reconstruction and maxillo-facial implants.

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PRODUCT DIFFERENTIATION →→ Simpler and cost-effective manufacturing method. →→ The foam biomimetic structure improves biocompatibility and therefore tissue osseointegration. →→ Thanks to its porosity this part may also be used as a coating to obtain a density-porous structure which guarantees mechanical property.

UHMWPE FOAMS WITH CONTROLLED POROSITY AND PORE DIAMETER FOR APPLICATION IN JOINT PROSTHESIS.

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Contacts: GARBIÑE ATORRASAGASTI garbine.atorrasagasti@tecnalia.com

GORAN BIJELIC goran.bijelic@tecnalia.com

NEREA BRIZ nerea.briz@tecnalia.com