2023 University of Michigan Kellogg Eye Center Annual Report

Page 18

WE BELIEVE IN THE

TRANSFORMATIVE POWER

OF RESEARCH, THAT’S WHY

WE DO ALL WE CAN TO SUPPORT EVERY AMAZING PATIENT WHO STEPS UP TO PARTICIPATE IN A CLINICAL STUDY.

— Julie Rosenthal, M.D., M.S.

Julie Rosenthal, M.D., M.S., James Green, CCRP, Lianne Shami, B.S., Kevin Haynes

KCRC Assists in Michigan Medicine Research with Consequences for Eyes At Kellogg, research involving patients is coordinated through the Kellogg Clinical Research Center (KCRC). The KCRC provides the staff, infrastructure and resources to see a clinical study from initial Institutional Review Board approval through final data reporting. Since opening its doors in 2015, clinical research volume at the KCRC has grown to more than 360 active studies, including more than 300 investigator-initiated studies and 50+ sponsored studies. Along with coordinating the hundreds of patient interactions and protocol details required for those projects, a special team within the KCRC assists researchers from other Michigan Medicine departments whose studies have potential consequences for eye health. “Many treatments for cancers and other diseases have potential ocular side effects,” explains Julie Rosenthal, M.D., M.S. The Associate Medical Director of the KCRC, Dr. Rosenthal oversees the Collaborative Ophthalmic Research Support (CORS) unit. “The clinical trials that evaluate those medications have specific protocols for monitoring participants’ eyes. Our team coordinates all of those eye-related components.” Along with Dr. Rosenthal, the CORS team includes KCRC Administrative Director James Green and Clinical Research Coordinators Kevin Haynes and Lianne Shami. A CORS study protocol—which can exceed 100 pages— is first thoroughly reviewed and its eye-related components consolidated. A plan is developed, detailing the required testing, imaging and measurements, and identifying which Kellogg specialists are needed. 16

With a plan in place, every patient interaction is managed through the ODS team to streamline the process for everyone involved. “Without this centralized service, patients might be seen by Kellogg physicians without knowledge of the protocol, which could lead to incorrect or incomplete examinations and testing,” notes Dr. Rosenthal. “This could jeopardize the viability of the studies of our Michigan Medicine research partners.” “Most appointments begin with a workup at the KCRC, after which Kellogg doctors complete the examinations,” explains James Green. “It’s quite a scheduling challenge,” adds Kevin Haynes. “We try to work with the patient’s existing study appointments, to minimize trips to the medical campus, and coordinate with the availability of the right Kellogg specialists for exams and imaging.” Currently, the KCRC is providing support for more than 60 active CORS studies, coordinating with researchers in endocrinology, oncology, neurology, immunology, pediatrics and more. “In a cancer drug trial, we may be monitoring for side effects like changes in vision or intraocular pressure,” Lianne Shami explains. “In studies of genetic syndromes, we may be watching for visible changes in the cornea, in the case of Wilson’s disease, or the development of tumors in Von Hippel-Lindau disease.” A comprehensive resource like the KCRC is rare, even in the largest academic eye centers. Extending that same high level of support to researchers in other specialties is a testament to Kellogg’s commitment to cooperation in advancing in research while delivering outstanding patient care. “We believe in the transformative power of research,” says Dr. Rosenthal, “That’s why we do all we can to support every amazing patient who steps up to participate in a clinical study.”


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Articles inside

Partnership between U-M Med School, Business School, and the Kellogg Eye Center Drives Latest Kenya

4min
pages 38-39

The Edna H. Perkiss Research Professorship in Ophthalmology and Visual Sciences

3min
page 37

Honoring the Visionary Leadership of Paul P. Lee, M.D., J.D.

3min
page 36

The Alan Sugar, M.D., Research Professorship in Ophthalmology

3min
page 35

Mark W. Johnson, M.D., Honored with Heed-Gutman Award

2min
page 34

Protecting Retinal Neurons from Diabetes

2min
page 34

Mining Big Data for Novel Glaucoma Genes

3min
page 33

Beyond the Electronic Health Record

5min
pages 32-33

Applauding a Good Catch

2min
page 31

Microneedles for Sustained Retinal Drug Delivery

2min
page 30

Alumni Highlights

4min
pages 29-30

Lecture in Professionalism and Ethics

1min
page 29

Molecular Imaging of Macular Degeneration

2min
page 28

Institutional Grants Anchor Research Infrastructure, Training

5min
pages 26-27

2023-2024 Heed Fellows

5min
pages 24-25

Pre-Med Awarded NIH Research Supplement

2min
page 23

Kellogg PGY4 Sole Resident on ACGME Residency Program Review Committee

2min
page 22

Kellogg Post-Doc Receives Prestigious NIH Grant

2min
page 21

An Out-of-This-World Perspective on Residency from one of Forbes’ Thirty-Under-Thirty

3min
page 20

Expanding Personalized Treatment and Clinical Research in Uveitis

3min
page 19

KCRC Assists in Michigan Medicine Research with Consequences for Eyes

3min
page 18

Editing Genes to Treat Corneal Dystrophies

3min
page 17

Using Artificial Intelligence to Improve IOL Formulas

3min
page 16

Selfless Service Beyond Kellogg’s Walls

1min
page 15

The Genes That Drive Eye Size

2min
page 15

Image-Guided Medical Robotics Comes to Kellogg

3min
page 14

How Inflammation Triggers Photoreceptor Regeneration

2min
page 13

The Molecular Physiology of the Blood-Retinal Barrier

3min
page 12

Prioritizing Patient Wellness—and Our Own

3min
page 11

Michigan's 15th President Joins the Department

3min
page 10

Patent Issued for Photo-Mediated Ultrasound Therapy

1min
page 9

Unlocking the Therapeutic Potential of Tears

2min
page 9

Oculoplastics: Building on an Extraordinary Legacy

3min
page 8

Assessing Age-Related Vision Impairment

3min
page 7

For IRD Patients, Tailored Interventions Address Impaired Vision and Related Distress

3min
page 6

A Rare Syndrome, A Team Approach

4min
pages 4-5

2023 University of Michigan Kellogg Eye Center Annual Report

3min
page 3
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