2012 Annual Report

the direction of the college

THE UNIVERSITY OF TOLEDO College of Pharmacy and Pharmaceutical Sciences 2012 Annual Report

On_the_Rise

the direction of the college

During the past year, the College of Pharmacy and Pharmaceutical Sciences at The University of Toledo has undergone a transformative process of redefining and refining our mission, goals and strategic plan. The faculty, staff and administration of the college, together with the input of students and alumni, have engaged in thoughtful discourse about the direction of the college and the way forward.

By revising the strategic plan and completing a reaccreditation cycle, we can better articulate what makes our college outstanding. Building on our historic success, we have agreed upon the ways in which we define our own success. As always, the success of our college aligns us with the university along with the pharmacy and research communities to which we are intricately connected. Our collaborative environment and student-centered culture contributes to our steadfast commitment to education and improving the human condition.

The college’s success is demonstrated by the continued achievement and advancement of the metrics in our strategic plan and supported by the faculty, staff, students, alumni and community partners who are so committed to our college. Together, we are prepared to meet the current and future health care needs of society. We have achieved so much in the past year, and we are still on the rise.

on_the_rise_2012_annual_report

the university of toledo college of pharmacy and pharmaceutical sciences Mission

The mission of the College of Pharmacy and Pharmaceutical Sciences is to educate students to become pharmacists and pharmaceutical scientists while advancing pharmaceutical knowledge. Our guiding principles are personal integrity, respect for humanity and human diversity, and professionalism.

Vision

The University of Toledo College of Pharmacy and Pharmaceutical Sciences will improve the human condition by developing pharmacists and by advancing knowledge together with its application through research. This vision will be achieved through student-centered instruction and research in a collaborative, dynamic academic and practice environment.

Goals

The goals of the College of Pharmacy and Pharmaceutical Sciences are: • To provide society with pharmacists who are leaders in the profession; • To provide society with leaders in the pharmaceutical sciences; • To serve the profession by achieving prominence in pharmacy education and research; and • To provide students with an optimal learning environment to attain personal and professional growth and success.

Core Values

The College is committed to promote a culture which values: • Our students, alumni, staff, preceptors and faculty. We encourage strong positive relationships among these groups and support their professional development; • Human diversity; • Teaching, learning and interprofessional education for undergraduates, graduates and post-graduates; • Pharmaceutical science and clinical research and the translation of the same to pharmacy practice; • Human health and wellbeing through patient-focused pharmacy practice.

1

the direction of the college

on_the_rise_2012_annual_report

Quality Undergraduate and Professional Educational Programs The bachelor of science in pharmaceutical sciences program continues to attract students interested in medicinal chemistry, pharmaceutics, pharmacy administration and pharmacology. The doctor of pharmacy program remains strong, preparing graduates to become practicing pharmacists. Graduate education in the College of Pharmacy and Pharmaceutical Sciences includes the Ph.D. in medicinal chemistry, a program that has produced successful graduates for more than 20 years. The college also offers a master of science in pharmaceutical sciences with majors in industrial pharmacy, health outcomes and socioeconomic sciences (formerly pharmacy health care administration) and pharmacology/toxicology.

NEW ACADEMIC PROGRAMS Cosmetic Science

The Department of Pharmacy Practice developed a new BSPS major, cosmetic science, which began in fall 2012 with two P1 students. The program is the brainchild of Dr. Ken Alexander, professor of pharmacy practice, who largely developed the curriculum and shepherded the proposal through the approval process. The department hired its first faculty member for the program, Dr. Gabriella Baki, an alumnus of the exchange program with the University of Szeged, Hungary Faculty of Pharmacy.

BSPS/MS in Medicinal Chemistry

Dr. Marcia McInerney, chair of the Department of Medicinal Chemistry, developed a program in which students can obtain both a bachelor of science and a master of science in pharmaceutical sciences degree in five calendar years.

The program allows BSPS students to choose a faculty mentor as an internship mentor during the undergraduate years and continue the master of science thesis research with the same mentor.

Experimental Therapeutics Ph.D.

The Department of Pharmacology, chaired by Dr. William Messer, received formal approval for implementing a Ph.D. program in experimental therapeutics. The program will enroll students beginning in fall 2013. Experimental therapeutics is the integration of basic and applied sciences focused on the study and development of new treatments for human disease. Experimental therapeutics is a multi-disciplinary field, drawing on a variety of scientific areas, including but not limited to pharmacology, toxicology, biochemistry, medicinal chemistry, cell and molecular biology, neuroscience, physiology, immunology, pharmaceutics, pathology, statistics and engineering.

Residency Programs

Residency programs in the college continue to thrive and attract highly motivated and talented pharmacists from across the nation. The Community Pharmacy PGY1 residency program was recently reaccredited by the American Society of Health-system Pharmacists. The Community Pharmacy residency program is a collaboration between the college and Kroger Company and is committed to developing well-rounded clinicians who are able to provide advanced practice services in a variety of clinical settings. The Hospital Pharmacy PGY1 residency, run through the UT Medical Center and pharmacist Todd Gundrum, will now accept eight residents per year, an increase from the previous limit of three residents. The PGY2 Critical Care residency continues to attract pharmacists who wish to practice in surgical, medical, cardiac, cardiothoracic, neuro/neurosurgical, trauma intensive care, transplant, infectious disease, clinical microbiology, infection control and epidemiology, and emergency medicine settings.

2

3

on_the_rise_2012_annual_report

Students The college seeks and has become a magnet for students who report with the highest credentials among Ohio high school students. Twenty-two such students enrolled with the distinction of being Contingent Admit students. Thirty-one students who had an ACT of 29 or above and a high school GPA of 3.75 or higher received a Pharmacy Excellence Scholarship, which covers the full cost of tuition.

On-time progression of students is yet another strength of the college. First-time students entering the College of Pharmacy and Pharmaceutical Sciences in 2011 and returning to UT in fall 2012 were retained at a rate of 73 percent. The average retention/graduation rate for students entering the P1 year of the PharmD class from 2002 to 2008 is 95.5 percent. The BSPS program has a retention rate of 85 percent, signaling another strong cohort of students who are destined for great careers and graduate or professional graduate degrees. Some among this population have also transferred to the PharmD program.

Graduate education Data shows a trend of decreasing graduate applications, which is being addressed through enhanced marketing efforts. Recruitment efforts will encompass research trainees in the NIH Minority Biomedical Research Support and Minority Access to Research Careers programs.

International students will continue to be a focus, given the success of Dr. Ezdihar Hassoun of in attracting four 2012 Iraqi government-supported students. The geographical origins of other students include India, China and Saudi Arabia.

Under the leadership of Dr. Wayne Hoss, college/department support for graduate students held steady at $1.3 million, with an additional $200,000 in stipends from research grants.

Total FY 2013 funding for graduate students is expected to increase to $1.6 million. A number of new self-paying and foreign government-supported students matriculated, in addition to a Fulbright scholar, keeping the total graduate population in the college at 48. Additional recruitment efforts during the year, together with increased funding, will result in a 15 percent increase to 54 graduate students for FY 2013.

4

55

PLACEMENT OF GRADUATES BSPS Program

PharmD Program • Approximately 52% entered pharmacy practice immediately following graduation

• 33.3% entered the workforce

28% 52%

• 19% entered residency or fellowship training, and • 28% were considering geography and multiple offers as of May 2012

Graduate pharmacists who immediately entered practice made the following choices:

19%

60%

In summer of 2012, a record number of bachelor’s degrees in pharmaceutical science (BSPS) students were placed in nationally competitive internships sponsored by the National Science Foundation (NSF).

The Summer Undergraduate Research Fellowships (SURF) provide intensive research-training experience for students preparing for careers in biomedical research. Also, students in STEM (science, technology, engineering and math) programs all over the country apply for these 10-week projects.

• 4% institutional practice • 4% designated ‘other’ which may include industry, long term care, consulting, nuclear or other areas of practice

• 6% were undeclared at the time of interview

33.3%

BSPS Internship Program

4% 4% 2%

• 90% entered community practice • 2% in ambulatory care and

• 60% entered graduate programs

6%

90%

This year, 14 percent of the BSPS students who completed laboratory internships were selected for SURF programs across the country. The medical schools at Case Western Reserve University, The Ohio State University and The University of Toledo are among those that have consistently selected BSPS students for SURF programs over the past several years.

The number of BSPS students earning these competitive internships indicates the excellent preparation students receive in the biomedical sciences, which places our students among the best in the nation.

Choice of residency training The choice of residency training among PharmD graduates continues to be popular. Of the individuals entering residency training the following experiences were chosen: • 61% entered an institutional based pharmacy practice residency

11% 21%

7% 61%

• 21% entered an ambulatory care or community based residency • 11% entered a management based residency • 7% unknown

66

77

PHARMACY SUMMER CAMP For the 2011-2012 academic year, Pharmacy Summer Camp applications were received from 113 students. Eighty students were accepted to camp, and 79 attended. • 20 students reported an ethnic background other than Caucasian/White:

o o o o

10 African American Five Asian American Two Hispanic/Latino, and Three Other

• There were inquiries from students in 19 states: California, Connecticut, Georgia, Illinois, Indiana, Kentucky, Massachusetts, Maryland, Michigan, Minnesota, Missouri, New Jersey, New York, Ohio, Pennsylvania, Rhode Island, Texas, Virginia and West Virginia. o Sixty-five campers from Ohio o Twelve from Michigan o One each from Georgia, New York and Minnesota Eighteen students attended camp free of charge after receiving waivers of the $400 camp fee with proof of economic need in the form of a free or reduced lunch form, ACT/SAT test fee waiver, or a note from a school guidance counselor. A generous grant of $8,500 from Walgreens funded fee waiver scholarships. Walgreens has funded the camp since its inception in 2001.

Survey data from pharmacy campers revealed a high degree of satisfaction with camp presentations and activities led by CPPS faculty volunteers as well as shadowing a community pharmacist.

8 8

9

the direction of the college

RANKING OF THE COLLEGE

Faculty and Staff • The college is staffed by 52 faculty and 22 professional staff.

• The ACPE accreditation site team commended the dedication and commitment of the faculty, which goes well beyond the call of duty, for their exceptional work ethic and support of the program.

A 2011 study conducted by faculty members at Southwest Oklahoma State University College of Pharmacy ranked UT’s College of Pharmacy and Pharmacy and Pharmaceutical Sciences eighth in the U.S. and first in Ohio for teaching and value.

Rank

Teaching and Value

Facilities • The ACPE accreditation site team commended the college for the expansion to the Frederic and Mary Wolfe Center on the Health Science Campus, which has improved socialization of pharmacy students with other health professional students.

• The college was commended by the ACPE accreditation site team for the use of P3 (third-year) and P4 (fourth-year) PharmD students as teaching assistants for P1 and P2 laboratory and lecture courses. This was noted as a good model that should be communicated to the Academy for others to emulate.

• The Office of Student Affairs (OSA), led by associate dean Christine Hinko, was commended by the ACPE accreditation team for the office complete reorganization when the college expanded to the Health Science Campus, ensuring that students have the same high quality services on both campuses. The OSA developed its own secure electronic student record system that can be accessed from either campus.

OSA was also recognized for its efficiency and effectiveness in responding to student needs. The ACPE evaluation team received many positive comments from students concerning the OSA.

1

South Dakota State

2

Wisconsin-Madison

3

Georgia

4

Arkansas

5

Mississippi*

6

North Carolina-Chapel Hill*

7

Idaho State

8

Toledo

9

Ohio State

10

Cincinnati and Houston*

New Equipment • The new equipment fund, supported by alumni and donors, generated $92,000, which was combined with $13,000 from other CPPS funds to purchase equipment for teaching labs, including those for chemical synthesis, immunology and microbiology and pharmaceutics. A number of those pieces will also be used for research. A microplate reader was purchased primarily for research. In addition, a $26,000 budget amendment to the college overhead account purchased additional equipment for the cosmetic science program laboratories.

10

on_the_rise_2012_annual_report

An Optimal Learning Environment

*denotes a tie

U.S. News and World Report The college earned its first ranking in U.S. News and World Report as one of the top pharmacy schools nationwide.

11

the direction of the college

on_the_rise_2012_annual_report

Functional Governance and Organization As an outcome of the accreditation self-study and the revision of the strategic plan, the college has resolved to further cultivate a collegial and team-centered working environment among university and college administration, faculty, and staff. College committee charges were revised, and committees were revised and focused during this process.

ASSESSMENT COMMITTEE The Assessment Committee addressed orientation needs of faculty and student members. North American Pharmacist Licensure Examination (NAPLEX) data was reviewed and forwarded to the Dean’s Cabinet for discussion.

A review of the end of year (EOY) 2011 data and three-year trend data resulted in a plan for action on student research opportunity perceptions and “medication use management” term confusion.

Interested faculty members were to meet, with the goal of developing the consistent use of the term throughout the curriculum so that it is more readily recognized by students on surveys.

EOY data also pointed to the need for broader use of the Student Observer Program to help improve instruction. April Dix, higher education graduate assistant, developed a student observer program, which was initiated in spring 2012.

HUMAN DIVERSITY COMMITTEE The Human Diversity Committee agreed to sponsor at least one educational effort and one social activity per academic year. As the first social activity, the committee sponsored the “International Games” as a component of Pharmacy Pfield Day. Games included cricket, Chinese checkers, and mancala.

Plans for academic year 2012-2013 include the facilitation of diversity training for College faculty, staff, and students, and social activities celebrating diversity.

The P1 Diversity Workshop is an example of an educational effort sponsored by the committee.

The committee also plans to work with the college to develop appropriate language regarding diversity in the CPPS Strategic Plan.

12

13

The work of the Information Technology Committee is guided by the principle of placing contemporary technology materials into the hands of learners. A remaining challenge is the status of computers for staff and faculty. Committee co-chairs recommend an additional budgeted amount of $22,000 per year to allow for a four-year replacement schedule of aged units.

PROFESSIONAL CONDUCT COMMITTEE

on_the_rise_2012_annual_report

INFORMATION TECHNOLOGY

The Professional Conduct Committee revised the Code of Conduct was revised and approved so the code is now The University of Toledo Student Code of Professional Conduct, College of Pharmacy and Pharmaceutical Sciences: Policy Number: 3364-83-02.

SCHOLARSHIP COMMITTEE/SCHOLARSHIP AWARDS The Scholarship Committee awards students scholarships based on donor criteria. The number of applications rose from 273 to 305. Scholarship awards increased from 116 to 125, and the total paid amount increased from $85,000 to $94,530.

Scholarship applicants include students in the pre-professional division, the Bachelor of Science in Pharmaceutical Sciences program and the Doctor of Pharmacy program (P1-P4). The identity of applicants is not revealed to those who reviewed applications.

RESEARCH, SCHOLARSHIP AND GRADUATE EDUCATION The emphasis for Research, Scholarship and Graduate Education Committee was on improved research funding. Sustaining initial success in grant funding and improving the funding rate on submitted proposals continue as important issues. The committee has adopted the primary goal of creating a stronger culture of research and scholarship in graduate and professional education involving all students and faculty. Specific objectives are to increase research funding $3 million throughout five years and maintain that level and to increase NIH funding to $750,000 in three years.

The chief effort in support of this goal is to facilitate proposal development. Selected faculty members, a post-doctoral fellow and an advanced Ph.D. student participated in Dr. Bina Joe’s grant writing course. Effective October 1, 2012 the college will require external scientific review of grant proposals submitted to external agencies. The PI will arrange for an external, cognate qualified individual to review the proposal and provide a written critique.

14

15 15

RITUALS AND CEREMONIES The Rituals and Ceremonies Committee effectively organized several events that are central to the culture of the college and serve as platforms for acknowledging excellence among learners and staff.

This includes on-campus programs such as the professional advancement ceremony, fall convocation and the Ohio Licensure Ceremony.

Degrees conferred during the year included the following.

Fall Commencement Graduate

• Four master’s degrees in the Pharmaceutical Sciences

Bachelor of Science in Pharmaceutical Sciences • Eight Pharmacology/Toxicology • Four Medicinal and Biological Chemistry • Four Pharmacy Administration

Five students graduated cum laude, and seven graduated magna cum laude. One BSPS student graduated with Honors (from the Honors program).

Spring Commencement Graduate

• Two Ph.D. degrees in Medicinal Chemistry • 19 master’s degrees in the Pharmaceutical Sciences • 96 PharmD degrees • 106 BSPS degrees, PharmD major

Bachelor of Science in Pharmaceutical Sciences • • • •

25 Pharmacology / Toxicology 16 Medicinal and Biological Chemistry 15 Pharmacy Administration 18 Pharmaceutics

Graduation with Honors

Among the BSPS graduates, 56 graduated cum laude, 43 graduated magna cum laude, and 12 graduated summa cum laude (a total of 111 of the 180 graduates). Ten (10) BSPS candidates graduated with Honors: five with college Honors, and five with departmental Honors. There were four PharmD valedictorians (all with a GPA of 4.0) and one BSPS valedictorian.

16 16

17

the direction of the college

on_the_rise_2012_annual_report

Healthcare Access and Delivery Medication Therapy Management

Medication therapy management (MTM) remains a keystone of the college’s pharmacy practice mission. The college’s Pharmaceutical Care and Outcomes Research (PCOR) lab continues to collaborate with pharmacies and health care providers to create and assess MTM programs. The MTM expertise at UT has garnered international and national attention at various conferences and on multiple committees and panels. In fact, UT faculty provided advice and feedback to the New York Department of Health and Mental Hygiene and St. John’s University College of Pharmacy on developing successful MTM programs in addition to consultations with Walgreens, Cleveland Clinic and Fred’s Pharmacy.

- Antimicrobial Stewardship Program - Pharmacokinetic dosing service - Warfarin dosing and monitoring service - Heparin dosing service

patient care

Faculty members from the College of Pharmacy and Pharmaceutical Sciences provide pharmaceutical care in both in-patient and ambulatory care settings and maintain active practices at UTMC (inpatient care):

The University of Toledo Medical Center

18

Inpatient Clinical Pharmacy Services: UTMC clinical specialists, de-centralized pharmacists, PGY1 and PGY2 pharmacy residents and college faculty provide a wide variety of clinical services, from daily clinical duties and consults to educational responsibilities and rounding with multiprofessional teams. Clinical programs and services include:

Cardiology

Vince Mauro

Diabetes and Diabetes Education

Michelle Serres, Michelle Mangan

Emergency Medicine and Ambulatory Care

Michael Peeters

Family Practice/Medication Therapy Management

Aaron Lengel

Internal Medicine

Anita Stonehill-Ridner

Infectious Diseases/HIV

Eric Sahloff

Infectious Diseases/Antimicrobial Stewardship

Diane Cappelletty

Medical Critical Care

Laurie Mauro

Nephrology

Mariann Churchwell

Neurology and Movement Disorders

Gayle Kamm

Surgical Critical Care and Trauma

Martin Ohlinger

Neighborhood Family Practice, a Federally Qualified Health Center, Cleveland, OH: Chronic disease, addiction and psychiatric MTM services

Mary Borovicka

Community Health Center, a ProMedica facility: Primary care ambulatory practice

Megan Kaun

- Patient medication education - Renal dose monitoring - IV to PO monitoring - Precept and train Introductory Pharmacy Practice Experience (IPPE) and Advanced Pharmacy Practice Experience (APPE) students as well as residents - Pharmacists on the Floors (patient-centered integrated model) - Drug information services - Medication use evaluations - Development of clinical treatment pathways - Adverse drug event monitoring - Staff development and continuing education provided by clinical specialists - Published newsletters for the Health Science Campus - Performance improvement projects - Medication Safety Officer - Smoking cessation program - Therapeutic interchanges

19

2012 REACCREDITATION OF THE DOCTOR OF PHARMACY PROGRAM

Drs. Mary Borovicka and Eric Sahloff lead the Continuing Education Program.

The accreditation steering committee was co-chaired by Executive Associate Dean Wayne Hoss and Associate Dean Christine Hinko. A total of approximately 100 individuals, including 40 students, participated in the self-study, mock site visit and actual site visit by the American Council for Pharmacy Education (ACPE). The result was continued accreditation for the maximum eight-year period to 2020.

The college sponsored three continuing education events, with a total attendance of 117 pharmacists.

Program topics were: • Enhancing Adherence by “READ”ing with your Patients, and Ohio Law Review • MTM: Yes, You Can! • The Art of Creating the Culture of Professionalism during Experiential Education

Commitment to Global Outreach and Engagement INTERNATIONAL PARTNERSHIPS University of Szeged, Faculty of Pharmacy Since the signing of the agreement in 2006, the exchange of students has been robust. In the first year, 2008, three learners came to The University of Toledo. In 2011, two students, Beáta Deák and Balázs Dankó were placed in the laboratories of the Department of Medicinal and Biological Chemistry and the Center for Drug Design and Development.

North Sichuan Medical College The memorandum of understanding with the North Sichuan Medical College was the first established by the college in August 2002. During the visit of 2012, a revised document was developed and is awaiting a signing ceremony in Chengdu Province.

MEDICAL MISSIONS

on_the_rise_2012_annual_report

CONTINUING EDUCATION

Six commendations arose from the accreditation process, including: • The Office of Student Affairs (OSA), led by associate dean Christine Hinko, was commended for its complete reorganization when the college expanded to the Health Science Campus, ensuring that students have the same high quality services on both campuses. The OSA developed its own secure electronic student record system that can be accessed from either campus. OSA was also recognized for its efficiency and effectiveness in responding to student needs. The ACPE evaluation team received many positive comments from students concerning the OSA. • The dean was commended for improving communication within the college and making all leadership decisions transparent as well as maintaining an open-door policy that was mentioned positively by both students and faculty. The dean was also commended for accomplishing several major milestone goals for the college despite major financial and personal health issues.

• The college was commended for the accomplishment of several major events over the past two years, most notably the merger of the two universities, the expansion to the Health Science Campus, and the implementation of a new PharmD curriculum.

Honduras and Guatemala In 2008, Dr. Diane Cappelletty began conducting medical missions to Honduras. While the first mission trip only involved one pharmacy student, the annual program has grown to include 11 students in total.

In 2011, the medical mission program expanded to Guatemala with one student, Jessica Mullin, who also took another student in summer 2012. Jessica, who was one of the students who completed a previous medical mission in Honduras, is now a preceptor for missions for the college.

20

21

Financial data

total giving by category

New and Projected Extramural Funding

The total level of extramural funding for the College of Pharmacy and Pharmaceutical Sciences is about $1,450,000. Increases are projected for FY 2012 and 2013. The short-term goal is to grow the research program to reach a sustainable $3 million a year.

$439 Current or Former Student

Development

The University has initiated its “A University Rising” campaign, and the college chairperson for the campaign is Dr. Robert Schlembach.

Major gifts play a critical role in the operations of the College of Pharmacy and Pharmaceutical Sciences and the success of its students, supporting research, scholarships, equipment and other elements essential to the college’s growth and wellbeing. Annual gifts and pledge contributions remain strong, even among faculty and college leadership. Phonathon, the annual phone drive for donations, resulted in a myriad of gifts from alumni. The trends are positive in most domains, as shown below. The college’s challenge is to increase the amount of the average gift and to increase the participation rate among alumni and donors.

Average gift • FY10 – $72 • FY11 – $73 • FY12 – $89

$49,875

$68,219

Trust

Friend/Non-alum

$2,765 Other (non people)

100

80

$204,783

$264,651

Corporation

Alumnus/a

60

40

total giving

FY12

FY11

0

FY10

20

700,000

• $553,806.02 in FY 2010

600,000

• $469,391.92 in FY 2011

500,000

$34,000

• $637,283.29 in FY 2012

400,000

Corporate/Matching Gift Foundation

300,000

FY12

FY11

100,000

FY10

200,000

0

22

23

Department of Medicinal and Biological Chemistry The Department of Medicinal and Biological Chemistry expanded its research enterprise and created new knowledge as shown in the table below. Details on patents, papers, presentations and grants follow.

Paper of the week

Dr. James Slama published two papers that were designated “paper of the week” by the editors of the Journal of Biological Chemistry: 1.

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg. Timothy F. Walseth, Yaping Lin-Moshier, Pooja Jain1, Margarida Ruas, John Parrington, Antony Galione, Jonathan S. Marchant, James T. Slama, J. Biol. Chem., 287(4), 2308-2315, 2012.

2.

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells.

Yaping Lin-Moshier, Timothy F. Walseth, Dev Churamani, James T. Slama, Robert Hooper, Eugen Brailoiu, Sandip Patel, Jonathan S. Marchant, J. Biol. Chem., 287(4), 2296-2307, 2012.

Book chapters

Selective Estrogen Receptor Modulators, A. Luniwal, R. Jetson* and P. Erhardt in Analogue-Based Drug Discovery, J. Fischer Sr. Ed., Wiley-VCH Pub., Germany, pp. ca. 20 within textbook. Accepted.

8. Early Stage Efficacy and Toxicology Screening for Antibiotics and Enzyme Inhibitors, J. Sarver, J. Trendel, N. Bearss#, L. Wang, A. Luniwal*, P. Erhardt and R. Viola. J. Biomolecular Screening, 17, 673-682 (2012).

9. Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methusosis, a Novel Type of Nonapoptotic Cell Death, M. Robinson,* J. Overmeyer, A. Young, P. Erhardt and W. Maltese. J. Medicinal Chem., 55, 1940-1956 (2012).

10. Directing Drug Distribution: Avoiding Multidrug Resistance While Targeting Cancer Cells, P. Erhardt, W. Klis, J. Sarver and N. Bearss#. Proc. Int. Conf. Chem. for Mankind: Innovative Ideas in Life Sci., 34-37 (2012).

11. Analogue-based Drug Discovery: Contributions to Medicinal Chemistry Principles and Drug Design Strategies. Microtubule Stabilizers as a Case in Point, M. El-Dakdouki* and P. Erhardt. Pure & Applied Chem., 84, 1479-1542 (2012).

12. R. Zaidi and A. C. Bryant-Friedrich, The Effect of Reductant Levels on the Formation of Damage Lesions Derived from a 2-Deoxyribose Radical in ssDNA. Radiat. Res. 177, 565-572 (2012).

13. S. A. S. Audat*, C. Trzasko Love, B. A. S. Al-Oudat* and A. C. Bryant-Friedrich, Synthesis of C3’ Modified Nucleosides for Selective Generation of the C3’-Deoxy-3’-thymidinyl Radical: A Proposed Intermediate in LEE Induced DNA Damage.

J. Org. Chem. 77, 3829-3837 (2012).

14. Sachin Patil* • Lilly M. Saleena • Yong-Wah Kim • Edith Weber • Hermann von Grafenstein. Expression and Purification of Isotopically Enriched MHC Binding Immunogenic Peptides for NMR Studies, , Int J Pept Res Ther (2011) 17:137–145

15. Shadia N. Nada and Zahoor A. Shah. (2012) Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection by inducing Nrf2, HO1 and CRMP2. Neurobiology of Disease. Apr;46(1):180-9.

16. Nesamony J, Singh, P.R, Nada, S.E, Shah, Z.A, Kolling, W.M. (2012) Calcium alginate nanoparticles synthesized through a novel interfacial cross-linking method as a potential protein drug delivery system. J Pharaceutical Sciences. 2012 Jun;101(6):2177-84.

Refereed Publications

1. Multigram Synthesis of Glyceollin I, A. Luniwal,* R. Khupse*, M. Reese#, J. Liu, M. El-Dakdouki*, N. Malik*, L. Fang# and P. Erhardt. Org. Process Res. Dev., 15, 1149-1162 (2011).

18. Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells.

Yaping Lin-Moshier, Timothy F. Walseth, Dev Churamani, James T. Slama, Robert Hooper, Eugen Brailoiu, Sandip Patel, Jonathan S. Marchant, J. Biol. Chem., 287(4), 2296-2307, 2012. (Designated as “paper of the week” by editors of The Journal of Biological Chemistry) PMCID: PMC3268391 [Available on 2013/1/20]

2. Syntheses of 2,3-Diarylated 2H-Benzo[e][1,2]Thiazine-1,1-Dioxides and their 3,4-Dihydro Derivatives, and Assessment of their Inhibitory Activity Against MCF-7 Breast Cancer Cells, Y-Y. Shan, C-M. Zhang*, L-Q. Tang, Z-P. Liu, N. Bearss#, J. Sarver, A. Luniwal* and P. Erhardt. Medicinal Chemistry, 7, 561-571 (2011).

3. Hypoxia Activated Prodrugs of a 9-Aza-Anthrapyrazole Derivative That Has Promising Anticancer Activity, M. El-Dakdouki,* P. Erhardt, M. Hacker, N. Adamski and L. Foster. J. Med. Chem., 54, 8224-8227 (2011).

4. Hitting a Soft Drug with a Hard Nucleophile: Preparation of Esmolol’s Metabolite by Treatment with Bis(tributyltin)oxide, C. Zhang* and P. Erhardt. Synthetic Comm., 42, 722-726 (2012).

24

7. Molecular Docking and Enzymatic Evaluation to Identify Selective Inhibitors of Aspartate Semialdehde Dehydrogenase, A. Luniwal*, L. Wang, A. Pavlovsky, P. Erhardt and R. Viola. Bioorganic and Medicinal Chem., 20, 2950-2956 (2012).

17. Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg. Timothy F. Walseth, Yaping Lin-Moshier, Pooja Jain1, Margarida Ruas, John Parrington, Antony Galione, Jonathan S. Marchant, James T. Slama, J. Biol. Chem., 287(4), 2308-2315, 2012. (Designated as “paper of the week” by editors of The Journal of Biological Chemistry) PMCID: PMC3268392

(MBC faculty-bold, Postdoc^, PhD student or PhD graduate *, MS #, undergraduates +)

on_the_rise_2012_annual_report

PUBLICATIONS and PATENTS BY DEPARTMENT

19. Wendland, T. R*., Muntean, B. S*., Jaskiran Kaur, J., Mukherjee, J. Chen, J., Tan, X., Attygalle, D., Collins, R. W., Kirchhoff, J. R., Tillekeratne, L. M. V. In situ self assembly of thiolated ortho-quinone capped electrocatalysts for bioanalytical applications. Electroanalysis, 2011, 23, 2275-2279

20. Bhansali, P*., Hanigan, C. L., Casero, R. A. Jr. and Tillekeratne, L. M. V. Largazole and Analogues with Modified MetalBinding Motifs Targeting Histone Deacetylases: Synthesis and Biological Evaluation. J. Med. Chem. 2011, 54, 7453-7463 This publication is associated with Bhansali’s dissertation.

5. On the Interaction of Aliphatic Amines and Ammonium Ions with Carboxylic Acids in Solution and in Receptor Pockets, P. Nagy and P. Erhardt. J. Physical Chem. B, 116, 5425-5436 (2012).

21. Gegout, C. G., McAtee, M. L., Bennett, N. M., Tillekeratne, L. M. V., and Kirchhoff, J. R. Synthesis and Characterization of Luminescent Cadmium Selenide/Zinc Selenide/Zinc Sulfide Cholinomimetic Quantum Dots. Nanoscale, 2012, 4, 4719-4725.

6. Glyceollins, Soy Isoflavone Phytoalexins, Improve Oral Glucose Disposal by Stimulating Glucose Uptake, S. Boue, I. Isakova, M. Burow, H. Cao, D. Bhatnagar, J. Sarver, K. Shinde, P. Erhardt and M. Heiman. J. Agr. and Food Chem., 60, 6376-6382 (2012).

Accepted or In Press (MBC faculty in bold) 1. Isabel Escobar and Amanda Bryant-Friedrich, Northwest Ohio Chapter of the Association for Women In Science (AWIS) Women In Science Day Of Meetings (WISDOM). AWIS Magazine, accepted.

25

3. Nictinic Acid Adenine Dinucleotide 2’- Phosphate (NAADP) binding proteins in T lymphocytes. Timothy F Walseth, Yaping Lin- Moshier, Karin Weber, Jonathan S. Marchant, James T. Slama, and Andreas H Guse, Messenger In Press, for inaugural issue.

Patents and Patent Applications 1. Materials and Methods to Induce Cell Death via Methuosis, W. Maltese, P. Erhardt, J. Overmeyer, and M. Robinson.

Provisional Appln. 1-52611/D2011-38 Converted to Patent Submission, March, 2012.

2. Methods for Synthesizing Glycinols, Glyceollins I and II, Isoflavenes, and Chromanes Using a Wittig Reaction, and Compositions Made Therein, P. Erhardt, R. Khupse and A. Luniwal. US Patent Application Pub., US2012/0115942 A1, May, 2012.

3. Inhibitors of ERCC1-XPF Nucleases, S. Patrick and P. Erhardt. UT Invention Disclosure; Accepted for pursuing a provisional patent application.

10. Wu, Z., Liu, M.-C., Liang, M., and Fu, J., “Sirt1 Protects Against Thrombomodulin Downregulation and Lung Coagulation Following Particulate Matter Exposure,” Blood (2012) 119, 2422-2429.

11. Kanda, K., Nishi, K., Kadota, K., Nishimoto, S., Liu, M.-C., and Sugahara, T., “Nobiletin suppresses Adipocyte Differentiation of 3T3-L1 Cells by an Insulin and IBMX Mixture Induction,” Biochim. Biophys. Acta (2012) 1820, 461-468.

12. Shetty, S., Marudamuthu, A., Abernathy, D., Shetty, R., Shetty, P., Fu, J., Idell, S., Bhandary, Y., Ji, H.L., Liu, M.-C., and Shetty, S., “Regulation of Urokinase Expression at the Posttranscription Level by Lung Epithelial Cells,” Biochemistry (2012) 51, 205-213.

13. Kurogi, K., Krasowski, M.D., Injeti, E., Liu, M.-Y., Williams, F.E., Sakakibara, Y., Suiko, M., and Liu, M.-C., “A Comparative Study of the Sulfation of Bile Acids and a Bile Alcohol by the Zebra danio and Human Cytosolic Sulfotransferases (SULTs),” J. Steroid Biochem. Mol. Biol. (2011) 127, 307-314.

14. Hashiguchi, T., Kurogi, K., Sakakibara, Y., Yamasaki, M., Nishiyama, K., Yasuda, S., Liu, M.-C., and Suiko, M., “Sulfation of Tocopherols and Tocopherol Metabolites by Human Cytosolic Sulfotransferases,” Biosci. Biotech. Biochem. (2011) 75, 1951-1956.

The following Invention Disclosure has been filed and is under review.

15. Dokas, L.A, A.M. Malone, F.E. Williams, S.M. Nauli and W.S. Messer, Jr. Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells. Neuropharmacol. 61(1-2): 12-24, 2011.

Department of Pharmacology Peer reviewed publications 1. Jones BA, Koch AE, and Ahmed S. Pathological role of Fractalkine/CX3CL1 in rheumatic diseases: a unique chemokine with multiple functions. Front Immunol. 2: 82 (2011).

2. El-Dakdouki MH, Adamski N, Foster L, Hacker MP, Erhardt PW. Hypoxia activated prodrugs of a 9-aza-anthrapyrazole derivative that has promising anticancer activity. J.Med.Chem. 54(23): 8224-7, 2011.

3. Kiraly A, Koffman B, Hacker M, Gunning W, Rasche S, Quinn A. A novel aza-anthrapyrazole blocks the progression of experimental autoimmune encephalomyelitis after the priming of autoimmunity. Clin Immunol. 141(3): 304-16, 2011.

4. Hassoun E, Al-Dieri, A. Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice. Food and Chemical Toxicology. 50:701-706 (2012).PMID 22178223

5. Stohs, S; Hassoun, E. Dioxin-Activated AHR: Toxic Responses and the Induction of Oxidative Stress. In: The AH Receptor in Biology and Toxicology. Pohjanvirta, R (ed.); John Wiley & Sons, Inc. (Hoboken, New Jersey), Pp. 229-244 (2012).

6. Cearfoss J, Hassoun E. The effects of a low vitamin E diet on dichloroacetate- and trichloroacetate-induced oxidative stress in the livers of mice. J. Biochem. Mol. Toxicol. (In Press). DOI 10:1002/jbt

7. Kurogi, K., Alazizi, A., Liu, M.-Y., Sakakibara, Y., Suiko, M., Sugahara, T. and Liu, M.-C., “Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs,” Biochem.

Pharmacol. (2012) In Press.

8. Ko, K., Kurogi, K., Davidson, G., Liu, M.-Y., Sakakibara, Y., Suiko, and Liu, M.-C., “Sulfation of Ractopamine and Salbutamol by the Human Cytosolic Sulfotransferases,” J. Biochem. (2012) 152, 275-283.

26

9. Mohammed, Y.I., Kurogi, K., Al Shaban, A., Xu, Z., Liu, M.-Y., Williams, F.E., Sakakibara, Y., Suiko, M., Bhuiyan, S., and Liu, M.-C., “Identification and Characterization of Zebrafish SULT1 ST9, SULT3 ST4, and SULT3 ST5,” Aquat. Toxicol.

(2012) 112-113, 11-18.

4. Materials and Methods Useful to Treat Neuroblastoma, J. Park, K. Hensley and P. Erhardt. Provisional Appln. 1-52610/ D2011-24, Filed Fall 2011.

Tillekeratne, L. M. V., Fedorka, S., and Taylor, W. A new class of highly selective anticancer agents targeting non-small cell lung cancer Xenoantigen-displaying anti-cancer vaccines and method of making. S. Sucheck, K. A. Wall, and S. Sarkar, provisional patent application 1-53665/D2012-14, submitted February 2012.

on_the_rise_2012_annual_report

2. Synthesis, Biochemical Activity, and Structure-Activity Relationship Among Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Analogs, (2012) Christopher Trabbic2, Timothy F. Walseth, and James T. Slama, Messenger, In Press

16. Nagy, P.I., F.R. Tejada, Y.-W. Kim and W.S. Messer, Jr. Theoretical studies of the solvent effect on conformational equilibria and atomic charges for isolated and hydrogen-bonded dimethoxy thiadiazoles. Comp. Theor. Chem. 966: 194-206, 2011.

17. Ragozzino, M.E., S. Artis, A. Singh, T.M. Twose, J.E. Beck and W.S. Messer, Jr. The selective M1 muscarinic cholinergic agonist CDD-0102A enhances working memory and cognitive flexibility. J. Pharmacol. Exp. Therap. 340: 588-594, 2012.

18. Nauli SM. Editorial Focus: An ACE inhibitor improves vascular outcomes in a PKD model. Am J Physiol Renal Physiol.

301(5): F958, 2011.

19. Abdul-Majeed S, Nauli SM. Polycystic diseases in visceral organs. Obstet Gynecol Int.;2011:609370, 2011.

20. Abdul-Majeed S, Moloney BC, Nauli SM. Mechanisms regulating cilia growth and cilia function in endothelial cells.

Cell Mol Life Sci. 69(1): 165-73, 2012.

21. Jones TJ, Adapala RK, Geldenhuys WJ, Bursley C, AbouAlaiwi WA, Nauli SM, Thodeti CK. Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization. J Cell Physiol. 227(1): 70-6, 2012.

22. AbouAlaiwi WA, Rodriguez I, Nauli SM. Spectral karyotyping to study chromosome abnormalities in humans and mice with polycystic kidney disease. J Vis Exp. Feb 3;(60), 2012.

23. Jones TJ, Nauli SM. Mechanosensory calcium signaling. Adv Exp Med Biol. 740: 1001-15, 2012.

24. Nesamony J, Zachar CL, Jung R, Williams FE, Nauli SM. Preparation, characterization, sterility validation, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications. Drug Dev Ind Pharm. 2012 [In Press] 25. Y. Sari, Z.M. Segu, A. YoussefAgha, J.A. Karty, and D. Isailovic. Neuroprotective peptide, ADNF-9, in fetal brain of C57BL/6 mice exposed prenatally to alcohol. J. Biomed. Sci. (2011) 18(1): 1-12.

26. Y. Sari, J.M. Weedman, S. Ge. Activity-dependent neurotrophic factor-derived peptide prevents alcohol-induced apoptosis, in part, through Bcl2 and JNK signaling pathways in fetal brain of C57BL/6 mouse. Neuroscience (2012) 202: 465-473 27. H.W. Nam, S.R. McIver, D.J. Hinton, M.M. Thakkar, Y. Sari, F.E. Parkinson, P.G. Haydon, and D-S. Choi. Adenosine and Glutamate Signaling in Neuron-Glial interactions: Implications in Alcoholism and Sleep Disorders. Alcoholism: Clin Exp Res, (2012) 36(7): 1117-25.

27

29. Y. Kawanabe, M. Takahashi, S. Abdul-Majeed, Y. Sari, S.M. Nauli. Effect of cilostazol on extracellular calcium influx in smooth muscle contraction and proliferation. PLoS ONE, 2012;7(9):e44476.

30. Y. Sari. Role of 5-HT1B receptors in the regulation of Ethanol intake in rodents. J. Psychopharmacology, in press.

31. Greenwald MK, Steinmiller CL, Śliwerska E, Lundahl LH, Burmeister M (2012, epub) BDNF Val66Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals. Addiction Biology.

32. Steinmiller CL, Diederichs C, Roehrs TA, Hyde M, Greenwald MK, Roth T (2012) Post-surgical patient controlled morphine self-administration is greater in hospitalized abstinent smokers than non-smokers. Journal of Opioid Management 8(4):227-235.

33. Greenwald MK, Lundahl LH, Steinmiller CL (accepted Aug 2012) Yohimbine increases opioid-seeking behavior in heroindependent, buprenorphine-maintained individuals. Psychopharmacology.

Books and book chapters 1. Muntean BS, Jin X, Nauli SM. Primary cilia are mechanosensory organelles with chemosensory roles. Springer Publisher. c2012; Chapter 9, p.201-222 (ISBN 978-94-007-2003-9) 2. Nauli SM. Primary cilia are mechanosensory organelles in vascular tissues. Proceedings of the 15th World Congress on Heart Disease. Medimond International Proceedings. c2011; p.23 [ISBN: 978-88-7587-617-3]

Department of Pharmacy Practice Books and book chapters 1. Alexander K. “Local Anesthetics ” in Remington’s Pharmaceutical, Lloyd Allen, editor, Pharmaceutical Press, London, England, published March 2012 2. Alexander K. “Topical Drugs” in Remington’s Pharmaceutical, Lloyd Allen, editor, Pharmaceutical Press, London, England, published March 2012

3. Alexander K. monographs for Cottonseed Oil, Corn Oil and Canola Oil, Pharmaceutical Excipient Handbook, APhA, published September 2011

4. Alexander K, Renukuntla J, Riga A, Boddu SHS. “ Excipients as Active Pharmaceutical Ingredients,“ in Excipents, Chapter Sections Editor, Sai S. Boddu

5. Mauro LS. Chronic Renal Failure In: , Baughman VL, Gonzales JP, Golembiewski J, Alvarez W, editors. Anesthesiology and Critical Care Drug Handbook. 10th Ed. Hudson, Ohio, LexiComp, 2011, 1786-90

6. Mauro LS. Continuous Renal Replacement Therapy. In: Baughman VL, Gonzales JP, Golilembiewski J, Alvarez W, editors.

Anesthesiology and Critical Care Drug Handbook. 10th Ed., Hudson, Ohio LexiComp, 2011., 1791-94

7. Barletta JF, Cooper B, OhlingerMJ. Chapter 18, Drug-Induced Coagulation Disorders, pp 265-294. In: Drug-Induced Complications in the Critically Ill Patient: A Guide for Recognition and Treatment. Copyright 2012. Society of Critical Care Medicine, Mount Prospect, IL, USA. 8.

Martin SJ, Micek ST, Wood CG. Antimicrobial Resistance. In Eds. Papadopoulos J, et al. Drug-Induced Complications in the Critically Ill Patient: A Guide for Recognition and Treatment. Society of Critical Care Medicine Press, Chicago IL. 2012

on_the_rise_2012_annual_report

28. P.S.S. Rao and Y. Sari. Glutamate transporter 1: target for the treatment of alcohol dependence. Current Medicinal Chemistry, in press.

Manuscripts 1. “The Determination of Kenneth S. Alexander the Density of Polyethylene Glycol Mixtures used as Suppository Bases”, Matthew Lynch, Nachiket Patel and Kenneth S. Alexander, International Journal of Pharmaceutical Compounding 2. “A Review of the Methods Used to Determine the Density Factor of a Chemical Entity using Cocoabuter as the Standard”, Christina Hart, Nachiket Patel and Kenneth S. Alexander, International Journal of Pharmaceutical Compounding 3. “A Comparison of the Density Factors Found in Remington’s Pharmaceutical Sciences and Those Determined Experimentally”, Christina Hart, Nachiket Patel and Kenneth S. Alexander, International Journal of Pharmaceutical Compounding

4. “The Density Factors for Pharmaceutical Compounds”, Courtney Hujdek. Nachiket Patel and Kenneth S. Alexander, International Journal of Pharmaceutical Compounding 5. “Thermal analysis of water and magnesium hydroxide content in commercial pharmaceutical suspensions of milk of magnesia”, L. Kaza, H. F. Sobhi, J. A. Fruscella, C. Kaul, S. Thukur, N.I. Perera, K. Alexander and A. T. Riga, Journal of Thermal Analysis and Calorimetry May 11 2012. DOI 10.1007/S10973-012-2429-9 online Springer Publishing 6. “A New Proposal: Calculating Density Factor for Drugs Using Cocoa Butter as the Standard”, Heather Walker, Vishak Sridhar and Kenneth S. Alexander, International Journal of Pharmaceutical Compounding,( 2011) Vol.15(6), 422-426

7. Cheila Mothe, Michelle Mothe, Alan T. Riga and K. S. Alexander, Thermal Analysis of Model bio-membrane human and snake skins, Journal of Thermal Analysis and Calorimetry, Online First, August 5, 2011.

8. S.G. Avula, K.S. Alexander and A.T. Riga, “Predicting eutectic behavior of drugs and excipients by unique calculations,” Erratum in Journal of Thermal Analysis and Calorimetry 103, 1, 421, 2011

9. Praneeth Samalla, Alan Riga, Hareesha Venumuddala, Manik Pavan Kumar Maheswaram, Dhruthiman Mantheni, Kenneth S Alexander, Novel Dielectric Analysis Techniques enhance characterization of Pharmaceutical Excipients relative to Classical Thermal Analysis DSC and TG, 39th North Am. Therm. Anal. Soc., August, 2011 NATAS Disc, paper on Pharmaceuticals 10. Jeff Fruscella, Lakshmi Swetha Kaza, Chris Kaul, Kenneth S Alexander, Alan Riga, Thermal Analysis of Water and Magnesium Hydroxide Content in Commercial Pharmaceutical Suspensions of Milk of Magnesia, 39th North Am. Therm.

Anal. Soc., August, 2011 NATAS Disc, paper on Pharmaceuticals 11. Dhruthiman Mantheni, Alan Riga, Manik Pavan Kumar Maheswaram, Indika Parera, Kenneth S Alexander, Premelt Studies of Drugs and other Solids by Dielectric and Calorimetric Analysis, 39th North Am. Therm. Anal. Soc., August, 2011 NATAS Disc, paper on Pharmaceuticals

12. Manik Pavan Maheswaram, Dhruthiman Mantheni, Indika Perera, Hareesha Venumuddala, Alan Riga, Kenneth Alexander, “Characterization of crystalline and amorphous content in pharmaceutical solids by dielectric thermal analysis “J Therm Anal Calorimetry, DOI 10.1007/s10973-011-2140-2

13. Jakimczuk PJ, Mauro VF, Alexander KS. Physical compatibility of sotalol hydrochloride injection with selected cardiovascular agents. Am J Health-Syst Pharm.

14. D’Arcangelo G, Mauro VF. Administration of cardiovascular medications in relation to food. Hosp Pharm.

15. Jacobs DM, Mauro VF. Pearls to prevent pharmacy perils: Drug-induced gingival hyperplasia. Ohio Pharmacist.

16. Taylor LA, Mauro VF. Incidence of bleeding in renally impaired patients receiving incorrectly dosed eptifibatide or bivalirudin while undergoing percutaneous coronary intervention. Ann Pharmacother. 2012; 46:35-41.

17. Bishop BM, Mauro VF, Khouri SJ. Practical considerations for the pharmacotherapy of pulmonary arterial hypertension.

Pharmacotherapy (accepted for publication).

18. Mauro LS. Chronic Renal Failure (Online database) In: Lexi Online, LexiComp, Inc. Available at http://online.lexi.com/lco/ action/doc/retrieve/docid/patch_f/5271

28

29

37. Peeters MJ, Serres ML. Overcoming Content Specificity in Admission Interviews: The Next Generation? Am J Pham Educ. 2012; 75 [Letter] (accepted)

21. Mangan, M.N., Powers, M.F. Drug Shortages and the Role of the Pharmacy Technician: A Review. J. Pharm. Technol.

27:247-250 (2011).

39. Gleason BL, Peeters MJ, Resman-Targoff BH, Karr S, McBane S, Kelley K, Thomas T, Denetclaw TH. An Active-Learning Strategies Primer for Achieving Ability-based Educational Outcomes. Am J Pharm Educ 2011; 75(9):article 186.

20. Mangan, M.N., Powers, M.F., Lengel, A.J. Student Pharmacists’ Perceptions of Barriers to Medication Adherence Counseling. Manuscript submitted to J. Pharm. Prac. July, 2012. Manuscript accepted for publication August, 2012.

38. Vaidya V, Peeters MJ, Partha G, Potnis P. Evaluating the association between type of prescription drug plan and asthma patients’ use of controller medications. Journal of Pharmaceutical Health Services Research. 2012; 3(2):65-9.

22. Powers, M.F., Mangan, M.N. OTC product: Bayer Advanced Aspirin. Pharm Today 17(10), 34 (2011).

40. Jones, K., Blumenthal, D., Burke, J., Condren, M., Hansen, R., Holiday-Goodman, M., and Peterson, C., “Interprofessional Education in Introductory Pharmacy Practice Experiences at US Colleges and Schools of Pharmacy”, American Journal of Pharmaceutical Education, 2012; 76 (5) Article 80. Submitted October 22, 2011; accepted February 11, 2012; published June 18, 2012.

23. Mangan, M.N., Powers, M.F. Sleep aid options for patients with acute insomnia.Pharm Today 18(5), 36 (2012).

24. Hohmeier, K.C., Mangan, M.N., Powers, M.F., Lengel, A.J., The Patient-Centered Medical Home and Community Pharmacists’ Perceptions. J. Pharm. Technol., 28,151-155 (2012)

25. Nesamony J., Singh P.R., Nada S.E., Shah Z.A., and Kolling W.M., 2012. Calcium alginate nanoparticles synthesized through a novel interfacial cross-linking method as a potential protein drug delivery system, J. Pharm. Sci., 101(6), 2177-2184.

26. Nesamony J., Zachar C.L., Jung R., Williams F.E., and Nauli S., 2012. Preparation, characterization, sterility validations, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications, Drug Dev. Ind. Pharm., (pagination not yet available, available online: (http://informahealthcare.com/action/doSearch?searchText=Nesamony&type =simple&filter=multiple&allowEmptyTermQuery=true&postback=true&categoryId=40008412)

27. Boddu SHS. Polymeric Nanoparticles for Ophthalmic Drug Delivery: An Update on Research and Patenting Activity.

Recent Patent on Nanomedicine. 2012;2(2):96-112. (Date of submission: 09/05/2011, Date of acceptance: 01/31/2012) 28. Gaudana RJ, Gokulgandhi MR, Boddu SHS, Mitra AK. Recent overview of ocular patents. Recent Pat Drug Deliv Formul.

2012;6(2):95-106. (Date of submission: 01/01/2012, Date of acceptance: 03/27/2012)

29. Boddu SHS, Vaishya R, Jwala J, Vadlapudi A, Pal D, Mitra AK. Preparation and Characterization of Folate Conjugated Nanoparticles of Doxorubicin using PLGA-PEG-FOL Polymer. Med chem. 2012;2:68-75. (Date of submission: 04/23/2012, Date of acceptance: 05/18/2012)

30. Jwala J, Vadlapatla R, Vadlapudi A, Boddu SHS, Pal DJ, Mitra AK. Differential expression of folate receptor-alpha (FR-α), sodium dependent multivitamin transporter (SMVT) and amino acid transporter (B (0, +)) in human retinoblastoma (Y-79) and retinal pigment epithelial (ARPE-19) cell lines. J Ocul Pharmacol Ther. 2012;28(3):237-44. (Date of submission: 08/17/201, Date of acceptance: 10/13/2011).

31. Churchwell MD. Use of in vitro renal replacement therapy models to estimate extracorporeal drug removal. J Clin Pharmacol. 2012 Jan;52(1 Suppl):35S-44S.

32. Churchwell MD. Nephrology. ACCP Updates in Therapeutics® 2012: The Ambulatory Care Pharmacy Preparatory Review and Recertification Course.

33. Vaidya V, Peeters MJ, Gautam Partha Priyanka Potnis “Evaluating Association between Type of Prescription Drug Plan and Asthma Patients’ use of Controller Medications” Journal of Pharmaceutical Health Services Research Volume 3: 2, pages 65–69, June 2012

34. Vaidya V, Pranav Patel “Health expenditure comparison of extended-release metoprolol succinate and immediate-release metoprolol tartarate.” Clinicoeconomics and Outcomes Research. Feb 2012 Volume 2012:4 Pages 49–56

35. Vaidya V, Blazejewski Lucas, Pinto Sharrel. (2012), Implementation of Medicare Part D and statin use among the elderly population with diabetes. Journal of Pharmaceutical Health Services Research, 2012 August [Epub ahead of print].

36. Song Hee Hong, Jing Liu, Sunghee Tak, Varun Vaidya, “The impact of patient knowledge of patient-centered medication label content on quality of life among older adults” Research in Social and Administrative Pharmacy, 2012 May 1. [Epub ahead of print]

30

on_the_rise_2012_annual_report

19. Mauro LS. Continuous Renal Replacement Therapy. (Online database) In: Lexi Online, LexiComp, Inc. Available at: http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/196260

41. Holiday-Goodman, M., “Entrepreneurship, resource management, organizational culture, and other “business” factors influencing pharmacy practice change”; Editorial published in Research in Social and Administrative Pharmacy 8 (2012), 269- 271. Submitted March 23, 2012; accepted April 25, 2012; published July 2012.

42. Vaidya V, Blazejewski L, Pinto S. “Implementation of Medicare Part D and Statin Use among Elderly Diabetic Population.”

Journal of Pharmaceutical Health Services Research. E-Published Aug 5, 2012.

43. Pinto S, Bechtol R, Partha G. “Evaluation of outcomes of a medication therapy management program for patients with diabetes.” J Am Pharm Assoc. 2012;52:519-523

44. Kamm, Gayle. Large Pipeline and New Safety Issues Likely to Change 1st Line Recommendations for Multiple Sclerosis.

MHC 2012; 2(2).

45. Martin SJ, Klochan, Shelly A. Medication Safety Systems in the ICU: Beware of the Humans. Pharmacy Practice news 2012; April: 35, 37-38.

46. Martin SJ. Dosing strategies to improve the treatment of Pseudomonas aeruginosa. Crit Care Med. 2012 Apr;40(4):1389-90 (guest editorial) 47. Martin SJ. Infectious Diseases, 3rd Edition. Book Review. Ann Pharmacother 2011 Sep 6

48. Nesamony J, Zachar CL, Jung R, Williams FE, Nauli S. Preparation, characterization, sterility validation, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications. Drug Dev Ind Pharm. 2012

BS in Pharmaceutical Sciences BSPS students recognized as co-authors of peer reviewed papers, published abstracts and of presentations before conferences.

The names of student authors are boldfaced and underlined.

1. Wendland, T. R., Muntean, B. S., Jaskiran Kaur, J., Mukherjee, J. Chen, J., Tan, X., Attygalle, D., Collins, R. W., Kirchhoff, J. R., Tillekeratne, L. M. V. In situ self assembly of thiolated ortho-quinone capped electrocatalysts for bioanalytical applications. Electroanalysis, 2011, 23, 2275-2279.

2. Brian A Jones, Koch AE, and Ahmed S. Pathological role of Fractalkine/CX3CL1 in rheumatic diseases: a unique chemokine with multiple functions. Front Immunol. 2: 82 (2011).

3. Ko, K., Kurogi, K., Davidson, G., Liu, M.-Y., Sakakibara, Y., Suiko, M., and Liu, M.-C., Sulfation of Ractopamine and Salbutamol by the Human Cytosolic Sulfotransferases, J. Biochem. (2012) 152, 275-283.

4. Brian A Jones, Rahman A, Beamer M, Wiczynski D, Abu-Alaiwi W, and Ahmed S. Role of ADAM17, p38 MAPK, and proteasome pathways in TNF-α and IFN-γ induced synthesis and shedding of Fractalkine/CX3CL1 in rheumatoid arthritis.

Arthritis Rheum. 2012 [Revision requested].

31

College of Pharmacy and Pharmaceutical Sciences The University of Toledo 2801 W. Bancroft St. Toledo, Ohio 43606-3390