Critical Limb Ischemia/Peripheral Arterial Disease HUMAN STUDIES A double blind randomized placebo controlled phase I/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia. Gupta PK, Chullikana A, Parakh R, Desai S, Das A, Gottipamula S, Krishnamurthy S, Anthony N, Pherwani A, Majumdar AS. J Transl Med. 2013 Jun 10;11:143. doi: 10.1186/1479-5876-11-143. FREE ARTICLE Efficacy of Autologous Bone Marrow Mononuclear Cell Therapy in Patients with Peripheral Arterial Disease. Wang ZX, Li D, Cao JX, Liu YS, Wang M, Zhang XY, Li JL, Wang HB, Liu JL, Xu BL. J Atheroscler Thromb. 2014 Jul 31. [Epub ahead of print] FREE ARTICLE A phase I study of human cord blood-derived mesenchymal stem cell therapy in patients with peripheral arterial occlusive disease. Yang SS, Kim NR, Park KB, Do YS, Roh K, Kang KS, Kim DI. Int J Stem Cells. 2013 May;6(1):37-44. FREE ARTICLE A phase II trial of autologous transplantation of bone marrow stem cells for critical limb ischemia: results of the Naples and Pietra Ligure Evaluation of Stem Cells study. Schiavetta A, Maione C, Botti C, Marino G, Lillo S, Garrone A, Lanza L, Pagliari S, Silvestroni A, Signoriello G, Sica V, Cobellis G. Stem Cells Transl Med. 2012 Jul;1(7):572-8. doi: 10.5966/sctm.2012-0021. Epub 2012 Jul 6. FREE ARTICLE A randomized, controlled pilot study of autologous CD34+ cell therapy for critical limb ischemia. Losordo DW, Kibbe MR, Mendelsohn F, Marston W, Driver VR, Sharafuddin M, Teodorescu V, Wiechmann BN, Thompson C, Kraiss L, Carman T, Dohad S, Huang P, Junge CE, Story K, Weistroffer T, Thorne TM, Millay M, Runyon JP, Schainfeld R; Autologous CD34+ Cell Therapy for Critical Limb Ischemia Investigators. Circ Cardiovasc Interv. 2012 Dec;5(6):821-30. doi: 10.1161/CIRCINTERVENTIONS.112.968321. Epub 2012 Nov 27. FREE ARTICLE Interim analysis results from the RESTORE-CLI, a randomized, double-blind multicenter phase II trial comparing expanded autologous bone marrow-derived tissue repair cells and placebo in patients with critical limb ischemia. Powell RJ, Comerota AJ, Berceli SA, Guzman R, Henry TD, Tzeng E, Velazquez O, Marston WA, Bartel RL, Longcore A, Stern T, Watling S. J Vasc Surg. 2011 Oct;54(4):1032-41. doi: 10.1016/j.jvs.2011.04.006. Epub 2011 Jul 31. FREE ARTICLE A randomized, controlled study of autologous therapy with bone marrow-derived aldehyde dehydrogenase bright cells in patients with critical limb ischemia.
Perin EC, Silva G, Gahremanpour A, Canales J, Zheng Y, Cabreira-Hansen MG, Mendelsohn F, Chronos N, Haley R, Willerson JT, Annex BH. Catheter Cardiovasc Interv. 2011 Dec 1;78(7):1060-7. doi: 10.1002/ccd.23066. Epub 2011 May 18. FREE ARTICLE Intraarterial administration of bone marrow mononuclear cells in patients with critical limb ischemia: a randomized-start, placebo-controlled pilot trial (PROVASA). Walter DH, Krankenberg H, Balzer JO, Kalka C, Baumgartner I, Schlüter M, Tonn T, Seeger F, Dimmeler S, Lindhoff-Last E, Zeiher AM; PROVASA Investigators. Circ Cardiovasc Interv. 2011 Feb 1;4(1):26-37. doi: 10.1161/CIRCINTERVENTIONS.110.958348. Epub 2011 Jan 4. FREE ARTICLE Rationale and design of the JUVENTAS trial for repeated intra-arterial infusion of autologous bone marrow-derived mononuclear cells in patients with critical limb ischemia. Sprengers RW, Moll FL, Teraa M, Verhaar MC; JUVENTAS Study Group. J Vasc Surg. 2010 Jun;51(6):1564-8. doi: 10.1016/j.jvs.2010.02.020. FREE ARTICLE Bone marrow-derived mononuclear cell therapy induces distal angiogenesis after local injection in critical leg ischemia. Duong Van Huyen JP, Smadja DM, Bruneval P, Gaussem P, Dal-Cortivo L, Julia P, Fiessinger JN, CavazzanaCalvo M, Aiach M, Emmerich J. Mod Pathol. 2008 Jul;21(7):837-46. doi: 10.1038/modpathol.2008.48. Epub 2008 May 16. FREE ARTICLE Therapeutical potential of blood-derived progenitor cells in patients with peripheral arterial occlusive disease and critical limb ischaemia. Lenk K, Adams V, Lurz P, Erbs S, Linke A, Gielen S, Schmidt A, Scheinert D, Biamino G, Emmrich F, Schuler G, Hambrecht R. Eur Heart J. 2005 Sep;26(18):1903-9. Epub 2005 Apr 26. FREE ARTICLE
PRECLINICAL STUDIES Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression. Shen WC, Liang CJ, Wu VC, Wang SH, Young GH, Lai IR, Chien CL, Wang SM, Wu KD, Chen YL. Stem Cells Dev. 2013 May 1;22(9):1408-18. doi: 10.1089/scd.2012.0445. Epub 2013 Feb 15. FREE ARTICLE Potentiated therapeutic angiogenesis by primed human mesenchymal stem cells in a mouse model of hindlimb ischemia. Lee EJ, Park HW, Jeon HJ, Kim HS, Chang MS. Regen Med. 2013 May;8(3):283-93. doi: 10.2217/rme.13.17. FREE ARTICLE Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia.
Iwase T, Nagaya N, Fujii T, Itoh T, Murakami S, Matsumoto T, Kangawa K, Kitamura S. Cardiovasc Res. 2005 Jun 1;66(3):543-51. Epub 2005 Mar 2. FREE ARTICLE Multipotent adult progenitor cells sustain function of ischemic limbs in mice. Aranguren XL, McCue JD, Hendrickx B, Zhu XH, Du F, Chen E, Pelacho B, Pe帽uelas I, Abizanda G, Uriz M, Frommer SA, Ross JJ, Schroeder BA, Seaborn MS, Adney JR, Hagenbrock J, Harris NH, Zhang Y, Zhang X, Nelson-Holte MH, Jiang Y, Billiau AD, Chen W, Pr贸sper F, Verfaillie CM, Luttun A. J Clin Invest. 2008 Feb;118(2):505-14. doi: 10.1172/JCI31153. FREE ARTICLE Haeme oxygenase promotes progenitor cell mobilization, neovascularization, and functional recovery after critical hindlimb ischaemia in mice. Tongers J, Knapp JM, Korf M, Kempf T, Limbourg A, Limbourg FP, Li Z, Fraccarollo D, Bauersachs J, Han X, Drexler H, Fiedler B, Wollert KC. Cardiovasc Res. 2008 May 1;78(2):294-300. Epub 2007 Dec 18. FREE ARTICLE Involvement of E-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle. Oh IY, Yoon CH, Hur J, Kim JH, Kim TY, Lee CS, Park KW, Chae IH, Oh BH, Park YB, Kim HS. Blood. 2007 Dec 1;110(12):3891-9. Epub 2007 Aug 15. FREE ARTICLE
REVIEW ARTICLES Clinical application of vascular regenerative therapy for peripheral artery disease. Suzuki H, Iso Y. Biomed Res Int. 2013;2013:179730. doi: 10.1155/2013/179730. Epub 2013 Nov 24. Review. FREE ARTICLE Gene therapy and cell-based therapies for therapeutic angiogenesis in peripheral artery disease. Shimamura M, Nakagami H, Koriyama H, Morishita R. Biomed Res Int. 2013;2013:186215. doi: 10.1155/2013/186215. Epub 2013 Nov 3. Review. FREE ARTICLE Cell therapy of peripheral arterial disease: from experimental findings to clinical trials. Raval Z, Losordo DW. Circ Res. 2013 Apr 26;112(9):1288-302. doi: 10.1161/CIRCRESAHA.113.300565. Review. FREE ARTICLE Mesenchymal stem cells as a treatment for peripheral arterial disease: current status and potential impact of type II diabetes on their therapeutic efficacy. Yan J, Tie G, Xu TY, Cecchini K, Messina LM. Stem Cell Rev. 2013 Jun;9(3):360-72. doi: 10.1007/s12015-013-9433-8. Review. FREE ARTICLE Stem cell therapy for critical limb ischemia: what can we learn from cell therapy for chronic wounds? Jadlowiec C, Brenes RA, Li X, Lv W, Protack CD, Collins MJ, Dardik A.
Vascular. 2012 Oct;20(5):284-9. doi: 10.1258/vasc.2011.201206. Epub 2012 Oct 19. Review. FREE ARTICLE Autologous bone marrow cell therapy for peripheral arterial disease. Botti C, Maione C, Coppola A, Sica V, Cobellis G. Stem Cells Cloning. 2012 Sep 6;5:5-14. doi: 10.2147/SCCAA.S28121. Review. FREE ARTICLE Treatment of peripheral arterial disease using stem and progenitor cell therapy. Lawall H, Bramlage P, Amann B. J Vasc Surg. 2011 Feb;53(2):445-53. doi: 10.1016/j.jvs.2010.08.060. Epub 2010 Oct 27. Review. FREE ARTICLE Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia? Murphy MP, Wang H, Patel AN, Kambhampati S, Angle N, Chan K, Marleau AM, Pyszniak A, Carrier E, Ichim TE, Riordan NH. J Transl Med. 2008 Aug 19;6:45. doi: 10.1186/1479-5876-6-45. Review. FREE ARTICLE
Please click on the title of the article to open abstract in PubMed. HUMAN STUDIES Both autologous bone marrow mononuclear cell and peripheral blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment. Dubsky M, Jirkovska A, Bem R, Fejfarova V, Pagacova L, Sixta B, Varga M, Langkramer S, Sykova E, Jude EB. Diabetes Metab Res Rev. 2013 Jul;29(5):369-76. doi: 10.1002/dmrr.2399. Therapeutic outcomes of transplanting autologous granulocyte colony-stimulating factor-mobilised peripheral mononuclear cells in diabetic patients with critical limb ischaemia. Mohammadzadeh L, Samedanifard SH, Keshavarzi A, Alimoghaddam K, Larijani B, Ghavamzadeh A, Ahmadi AS, Shojaeifard A, Ostadali MR, Sharifi AM, Amini MR, Mahmoudian A, Fakhraei H, Aalaa M, Mohajeri-Tehrani MR. Exp Clin Endocrinol Diabetes. 2013 Jan;121(1):48-53. doi: 10.1055/s-0032-1311646. Epub 2013 Jan 17. Intra-arterial allogeneic mesenchymal stem cells for critical limb ischemia are safe and efficacious: report of a phase I study. Das AK, Bin Abdullah BJ, Dhillon SS, Vijanari A, Anoop CH, Gupta PK. World J Surg. 2013 Apr;37(4):915-22. doi: 10.1007/s00268-012-1892-6. Long-term clinical outcome after intramuscular transplantation of granulocyte colony stimulating factor-mobilized CD34 positive cells in patients with critical limb ischemia. Kinoshita M, Fujita Y, Katayama M, Baba R, Shibakawa M, Yoshikawa K, Katakami N, Furukawa Y, Tsukie T, Nagano T, Kurimoto Y, Yamasaki K, Handa N, Okada Y, Kuronaka K, Nagata Y, Matsubara Y, Fukushima M, Asahara T, Kawamoto A. Atherosclerosis. 2012 Oct;224(2):440-5. doi: 10.1016/j.atherosclerosis.2012.07.031. Epub 2012 Jul 27. No difference in intra-arterial and intramuscular delivery of autologous bone marrow cells in patients with advanced
critical limb ischemia. Klepanec A, Mistrik M, Altaner C, Valachovicova M, Olejarova I, Slysko R, Balazs T, Urlandova T, Hladikova D, Liska B, Tomka J, Vulev I, Madaric J. Cell Transplant. 2012;21(9):1909-18. doi: 10.3727/096368912X636948. Epub 2012 Apr 2. Angiographic demonstration of neoangiogenesis after intra-arterial infusion of autologous bone marrow mononuclear cells in diabetic patients with critical limb ischemia. Ruiz-Salmeron R, de la Cuesta-Diaz A, Constantino-Bermejo M, Pérez-Camacho I, Marcos-Sánchez F, Hmadcha A, Soria B. Cell Transplant. 2011;20(10):1629-39. doi: 10.3727/096368910X0177. Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients. Kirana S, Stratmann B, Prante C, Prohaska W, Koerperich H, Lammers D, Gastens MH, Quast T, Negrean M, Stirban OA, Nandrean SG, Götting C, Minartz P, Kleesiek K, Tschoepe D. Int J Clin Pract. 2012 Apr;66(4):384-93. doi: 10.1111/j.1742-1241.2011.02886.x. Epub 2012 Jan 27. Therapeutical potential of autologous peripheral blood mononuclear cell transplantation in patients with type 2 diabetic critical limb ischemia. Ozturk A, Kucukardali Y, Tangi F, Erikci A, Uzun G, Bashekim C, Sen H, Terekeci H, Narin Y, Ozyurt M, Ozkan S, Sayan O, Rodop O, Nalbant S, Sıldıroglu O, Yalnız FF, Senkal IV, Sabuncu H, Oktenli C. J Diabetes Complications. 2012 Jan-Feb;26(1):29-33. doi: 10.1016/j.jdiacomp.2011.11.007. Epub 2012 Jan 11. Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia. Smadja DM, Duong-van-Huyen JP, Dal Cortivo L, Blanchard A, Bruneval P, Emmerich J, Gaussem P. Cytotherapy. 2012 Feb;14(2):232-9. doi: 10.3109/14653249.2011.627917. Epub 2011 Oct 31 Angiogenic potential of BM MSCs derived from patients with critical leg ischemia. Smadja DM, d'Audigier C, Guerin CL, Mauge L, Dizier B, Silvestre JS, Dal Cortivo L, Gaussem P, Emmerich J. Bone Marrow Transplant. 2012 Jul;47(7):997-1000. doi: 10.1038/bmt.2011.196. Epub 2011 Oct 10. No abstract available. Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. Lu D, Chen B, Liang Z, Deng W, Jiang Y, Li S, Xu J, Wu Q, Zhang Z, Xie B, Chen S. Diabetes Res Clin Pract. 2011 Apr;92(1):26-36. doi: 10.1016/j.diabres.2010.12.010. Epub 2011 Jan 8. Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer. Procházka V, Gumulec J, Jalůvka F, Salounová D, Jonszta T, Czerný D, Krajča J, Urbanec R, Klement P, Martinek J, Klement GL. Cell Transplant. 2010;19(11):1413-24. doi: 10.3727/096368910X514170. Epub 2010 Jun 7. Intraoperative adjunctive stem cell treatment in patients with critical limb ischemia using a novel point-of-care device. Kolvenbach R, Kreissig C, Cagiannos C, Afifi R, Schmaltz E. Ann Vasc Surg. 2010 Apr;24(3):367-72. doi: 10.1016/j.avsg.2009.07.018. Epub 2009 Nov 6. Enhancing limb salvage by non-mobilized peripheral blood angiogenic cell precursors therapy in patients with critical limb ischemia.
Mutirangura P, Ruangsetakit C, Wongwanit C, Chinsakchai K, Porat Y, Belleli A, Czeiger D. J Med Assoc Thai. 2009 Mar;92(3):320-7. Characterization and comparison of bone marrow and peripheral blood mononuclear cells used for cellular therapy in critical leg ischaemia: towards a new cellular product. Capiod JC, Tournois C, Vitry F, Sevestre MA, Daliphard S, Reix T, Nguyen P, Lefrère JJ, Pignon B. Vox Sang. 2009 Apr;96(3):256-65. doi: 10.1111/j.1423-0410.2008.01138.x. Epub 2008 Dec 15. Treatment with autologous bone marrow mononuclear cells in patients with critical lower limb ischaemia. A pilot study. Wester T, Jørgensen JJ, Stranden E, Sandbaek G, Tjønnfjord G, Bay D, Kollerøs D, Kroese AJ, Brinchmann JE. Scand J Surg. 2008;97(1):56-62. Autologous transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells improves critical limb ischemia in diabetes. Huang P, Li S, Han M, Xiao Z, Yang R, Han ZC. Diabetes Care. 2005 Sep;28(9):2155-60.