Horse Health

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31/3/09

12:17

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The UK’s leading equine health & well-being magazine

April/May 09 £2.95

Eradication of Strangles ‘real possibility’ By Louise Cordell LEADING UK researchers have solved the DNA sequence for the bacterium that causes Strangles – meaning that the eradication of the disease could soon be ‘a real possibility’. Strangles is the most common infectious equine disease and there is currently no effective treatment or vaccine. However, a consortium including the Animal Health Trust, the University of Cambridge and the Wellcome Trust Sanger Institute has now published genome sequences for Streptococcus equi. The findings provide new information on how these bacteria cause the disease and highlight many new areas for developing better diagnostic tests, therapies and preventative vaccines. Dr Andrew Waller, AHT head of bacteriology, said: “The publication of these genomes is the culmination of over seven years of research. We are extremely excited about their implication for future international work towards improving animal health.” The research, funded by The Horse Trust and the Horserace Betting Levy Board, has already enabled the AHT to develop DNA and blood tests to diagnose Strangles and efforts are now being concentrated on developing a safe and effective vaccine.

The team have also produced a DNA sequence for Streptococcus zooepidemicus, a relative of the Strangles bacteria which can cause inflammatory airway disease, upper respiratory disease and abortion in horses. S. equi evolved from S. zooepidemicus and Dr Matthew Holden, leader of the analysis team at the Wellcome Trust Sanger Institute, confirmed that the new genome findings show weaknesses in S. equi that had not been predicted. He said: “S. zooepidemicus and S. equi are brothers in arms who share a common ancestry but, while acquiring some genes, S. equi has been discarding others it no longer needs. “The makings of this pathogen may very well be its undoing: it has lost functions found in its more versatile relatives, and consequently finds itself backed into a corner. With the new improved diagnostics, and the prospect of an effective vaccine round the corner, eradication becomes a real possibility.” The research also has the potential to help other animals and even people, as many of the genes found in S. equi are very similar to those found in a type of Streptococcus that causes pharyngitis, toxic shock syndrome, impetigo and scarlet fever in humans.

It’s not every day you see polo in the centre of Birmingham, but Amy Guy – aka Siren from Sky One’s hit series Gladiator – had her first lesson in Chamberlain Square. The event was put on to celebrate the city hosting the first ever Celebrity Arena Polo competition, which is set to take place at the British Open Show Jumping Championship at Birmingham’s NEC. Amy will be appearing alongside Katie Price at

the event and they will compete against each other, both captaining a team of two professionals. Amy said: I am really excited about playing Polo at the British Open with Katie and some top professionals. “My Gladiator training keeps me fit, but I will be having a few lessons to get me prepared for the match!” Amy is pictured with her instructor, Rugy Polo Club proprietor Philip Baker.


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