Offer Patients a Revolutionary Approach to Build Bone A Clinical Overview of AlgaeCal Formulations
Learning Objectives
Facts About Osteoporosis
Research on Increased BMD
Importance of Calcium
What You Get With AlgaeCal
Why Calcium Alone Isn’t Enough
How Strontium Can Speed Results
How AlgaeCal is Different
Dosing and Contraindications
Facts About Osteoporosis
Osteoporosis Facts
For women over 50, broken bones are more common than heart attack, stroke and breast cancer—combined.
Source: National Osteoporosis Foundation
Osteoporosis Facts
For women over 50, broken bones are more common than heart attack, stroke and breast cancer—combined. For those over 50 (women and men), 80% of broken bones are caused by bone loss.
Source: National Osteoporosis Foundation
Osteoporosis Facts
The National Osteoporosis Foundation estimates that:
1 in 2 women over 50
&
1 in 4 men over 50
Will suffer an osteoporosis fracture.
Osteoporosis Facts
In the US, 300,000 annual hip fractures cause serious patient consequences. Six months later, only 15% of patients can walk across a room unaided. Source: Singer A, et al. Mayo Clinic Proc. 2015;90:53-62
25% Mortality
50% Need Walking Aid
25% Nursing Homes
Osteoporosis Facts
Patients With an Increased Risk of Bone Loss • Gastric Bypass Surgery • Autoimmune Disorders • Certain Cancer Treatments • Digestive & GI Disorders • Blood & Bone Marrow Disorders • Neurological Disorders
Osteoporosis Facts
Patients With an Increased Risk of Bone Loss • Gastric Bypass Surgery
• Menopause
• Autoimmune Disorders
• Perimenopause
• Certain Cancer Treatments
• Andropause
• Digestive & GI Disorders
• Endocrine & Hormonal Disorders
• Blood & Bone Marrow Disorders • Neurological Disorders
Osteoporosis Facts
Other Causes & Risk Factors After the age of 40, we lose about 1% of our bone mineral density every year. The following things can accelerate the loss.
Harmful Diet
Toxins
Diseases
Lifestyle
Osteoporosis Facts
Diagnosis & Testing DEXA Scan YA T-score
2 Normal
1 0 -1
Osteopenia
-2 -3 -4
Osteoporosis
-5 20
40
60 Age (years)
80
100
Recommended for • All women 65+ • All patients with contributing risk-factors
Osteoporosis Facts
Complementary Tests that Help Uncover Root Causes • Omega-3 Index
• Genetic Testing
• Vitamin D
• Intracellular Magnesium Test
• Vitamin K Assay
• 24-Hour Urine Hormone Test
• CTx/NTx Tests
• IgG Food Sensitivity Testing
• Heavy Metals Challenge
• Comprehensive Digestive Stool Analysis
Importance of Calcium
Importance of Calcium
Calcium is the most abundant mineral in our body and plays vital roles in cell, nerve, blood, and muscle functions.
Importance of Calcium
Too many Americans fall short of getting the amount of calcium they need every day and that can lead to bone loss, low bone density and even broken bones.” — National Osteoporosis Foundation
Importance of Calcium
Pitfalls of Traditional Calcium • Rock-based • Low bioavailability • Safety concerns (lack of supporting nutrients, such as D3 and K2)
Importance of Calcium
Calcium alone will not increase bone density for older people.” — National Osteoporosis Foundation
Source: Patient Educator, Univ. of Alabama at Birmingham (video on NOF site)
Importance of Calcium
8 6
Calcium alone can’t increase bone density.
Bone Mineral Density
4 2 0
-3%
-2 -4
Traditional Calcium Supplements Traditional calcium supplements can only slow bone loss a little.
-7%
-6 -8 Years
1
2
3
4
5
6
7
On average, we lose 1% of our bone density every year after age 40.
No Supplements Without calcium supplementation, the average person loses 1% of their bone each year.
How AlgaeCal Is Different
Why AlgaeCal?
AlgaeCal Plus contains plant-based calcium, plus over a dozen nutrients bones need. Few can get all of these from diet, especially as we age.
Why AlgaeCal?
Mission Vision
Guided by science and powered by nature, we inspire people to strengthen their bones.
A world without fear of bone loss.
Why AlgaeCal? Our Scientific Advisory Board
Prof. Didier Hans, PhD
Dr. Loren Fishman, MD, PhD
Dr. Carole McArthur, MD, PhD
Head of R&D, Cntr. of Bone Diseases, Lausanne Univ. Hospital CHUV, Switzerland
Med. Dir., Manhattan Physical Medicine & Rehabilitation
Prof. of Immunology, Univ. of MissouriKansas City; Dir., Residency Research in Pathology, Truman Medical Center.
Dr. Liz Lipski, PhD
Lara Pizzorno, MDiv, MA, LMT
Prof. and Dir., Academic Devel., Nutrition Programs in Clinical Nutrition at Maryland Univ. of Integrative Health.
Editor, Longevity Medicine Review; Sr. Medical Editor, Integrative Medicine Advisors; author, Healthy Bones Healthy You!
The Traditional Calcium Problem
8
Bone Mineral Density
6
Calcium alone can’t increase bone density.
4 2 0
-3%
-2 -4
Traditional Calcium Supplements Traditional calcium supplements can only slow bone loss a little.
-7%
-6 -8 Years
1
2
3
4
5
6
7
On average, we lose 1% of our bone density every year after age 40.
No Supplements Without calcium supplementation, the average person loses 1% of their bone each year.
Why AlgaeCal? +7.3%
8
Only AlgaeCal is clinically supported to increase bone density.
Bone Mineral Density
6
AlgaeCal AlgaeCal increased bone density each year for an average of 1.04%, as shown in clinical studies.
4 2 0
-3%
-2 -4
-7%
-6 -8 Years
1
2
3
4
5
6
With AlgaeCal’s formulation, instead of losing 7% in 7 years, your patients are gaining 7.3%. That’s a 14% swing!
7
Traditional Calcium Supplements Traditional calcium supplements can only slow bone loss a little. No Supplements Without calcium supplementation, the average person loses 1% of their bone each year.
Why AlgaeCal?
AlgaeCal Plus Increases Bone Density. No other natural product can legally make this claim!
Why AlgaeCal?
AlgaeCal Plus
Traditional Calcium
Increases BMD (bone mineral density)
Clinically supported in 3 human studies
• Can only slow bone loss
Bone-building nutrients
13 minerals and 3 vitamins
• Just 1 to 3 nutrients
Calcium derived from living plants
Red algae (Lithothamnion superpositum)
• Made from crushed rocks
DEXA guarantee
Scan-to-scan improvement after 1 year
• No guarantee
Research On Increased BMD
Study 1 Summary
Nutrition Journal
216 Participants
x10
This study, involving more than 200 women and men found that AlgaeCal formulations increased bone density by more than 2% on average.
> 2% Bone mineral density increases achieved
Study 1 Detail
Nutrition Journal 5.0% 4.5%
Annualized % BMD Changes
4.0%
Comparisons of mean annualized change in bone mineral density from baseline in two groups following the same bone-health plan, but with different formulations of an enhanced plant-based form of calcium.
3.5% 3.0% 2.5% 2.0% 1.5% 1.0% 0.5% 0.48%
0.0%
2.27%
2.18%
2.94%
-0.67%
3.72%
4.33%
-0.61%
-0.5% -1.0% -1.5% -2.0%
AlgaeCal and Strontium Boost
AlgaeCal Plus and Strontium Boost
Both formulas delivered real gains in BMD, though the one using the nutrients in AlgaeCal Plus performed best.
Study 2 Summary
International Journal of Medical Sciences
414 Participants
x10
Up to
This study, involving 414 post-menopausal women found that AlgaeCal formulations increased bone density by 1.3% to 4.1% in one year.
4.1%
Increase in bone density among postmenopausal women
Study 2 Detail
Annualized % BMD Changes
International Journal of Medical Sciences Exp Chng
-0.75%
AlgaeCal
The two groups incorporating strontium citrate show the highest average BMD increases.
1.3%
AlgaeCal and Strontium Boost
2.18%
2.0%
AlgaeCal Plus and Strontium Boost
3.72%
4.1% 4.1%
-1%
0%
1%
2%
3%
4%
5%
Study 3 Summary
Journal of the American College of Nutrition This award-winning study, found that 172 female participants who took AlgaeCal for 7 years saw an average annual bone density increase of 1.04%. That’s 7.3% more bone over 7 years!
172 Participants
x10
1.04% Average annual increase in bone density in women
The AlgaeCal Difference +7.3%
8
Only AlgaeCal is clinically supported to increase bone density.
6
AlgaeCal AlgaeCal increased bone density each year for an average of 1.04%, as shown in clinical studies.
Bone Mineral Density
4 2 0
-3%
-2 -4
-7%
-6 -8
Years
1
2
3
4
5
6
With AlgaeCal’s formulation, instead of losing 7% in 7 years, your patients are gaining 7.3%. That’s a 14% swing!
7
Traditional Calcium Supplements Traditional calcium supplements can only slow bone loss a little. No Supplements Without calcium supplementation, the average person loses 1% of their bone each year.
What Do You Get With AlgaeCal?
What Do You Get With AlgaeCal?
AlgaeCal A Complete Calcium Source
01 Ocean Algae
03 USDA Organic and Kosher
02 Sustainably Harvested
04 13 Bone-Essential Minerals
What Do You Get With AlgaeCal?
AlgaeCal Plus
More than a dozen nutrients that support increased bone density. • Calcium • Magnesium • Copper • Manganese • Silicon • Strontium • Nickel • Phosphorous
• Selenium • Vanadium • Zinc • Boron • Vitamin K2 (MK-7) • Vitamin D3 • Vitamin C
What Do You Get With AlgaeCal?
Vitamin D3 Supports Healthy Bones
Reduces Cancer Risk
Reduces Alzhiemer’s Risk
Decreases CV Disease
Protect Against Diabetes
Boosts Immunity
Combats Depression
Reduces Rheumatoid Arthritis
What Do You Get With AlgaeCal?
Magnesium Supports Bone Health
Improves Digestion and Alleviates Constipation Symptoms
Protects Against Diabetes
07 Relieves Insomnia
01
06 Protects Your Heart
02
05 Combats Asthma 04 Reduces High Blood
03
Pressure
What Do You Get With AlgaeCal?
Vitamin K2 (MK-7) Vitamin K2 activates GLA proteins that keep calcium away from your organs, arteries, and soft tissues, and carries it to where you need it the most-your bones!
Helps Prevent Bone Loss
Lowers Risk of Heart Disease
Lowers Cancer Risk
Longevity
Keeps Teeth Strong
Fights Autoimmune Conditions
What Do You Get With AlgaeCal?
Boron Ca
Mg
Helps Build Bone
Maintains Calcium Levels
Maintains Magnesium Levels
Extends Availability Of Vitamin D
Boron lowers osteoclastinducing inflammation and boosts osteoblast activity
Boron cuts the amount of calcium lost in urine by almost 50% and helps put more calcium in your bones
Boron improves your body’s ability to absorb and utilize magnesium
Boron helps men and women get the most bone-building benefit from vitamin D
What Do You Get With AlgaeCal?
Silicon (Orthosilicic Acid) Increases 01
02
03
04
Bone-specific alkaline phosphatase - an enzyme involved in osteoblasts’ boneforming activity
Osteocalcin, the vitamin K-dependent protein that escorts calcium into bones
Osteoblast proliferation and activity
Type 1 Collagen, which is associated with bone strength
What Do You Get With AlgaeCal?
Strontium Boost A natural mineral found in soil and throughout our food supply. • Increases calcium absorption • Boosts bone formation • Regulates bone breakdown • Reduces fracture risk independent of bone density
Study 2 Detail
Annualized % BMD Changes
International Journal of Medical Sciences Exp Chng
-0.75%
AlgaeCal
Of three test groups, all gained bone density. Plans 2 and 3 included strontium citrate.
1.3%
AlgaeCal and Strontium Boost
2.18%
2.0%
AlgaeCal Plus and Strontium Boost
3.72%
4.1% 4.1%
-1%
0%
1%
2%
3%
4%
5%
How Strontium Can Speed Results
Strontium
Strontium: Boosts Calcium Absorption 01
02
03
Calcium-sensing receptors (CaSR) are found on osteoblasts, the cells that build new bone.
Researchers have identified a new CaSR version that is only activated by strontium.
By activating CaSR, strontium helps increase calcium absorption.
Strontium
Regulates Bone Breakdown The Key Molecules that Control the Rate of Bone Breakdown
01 02
Strontium modulates RANKL, which activates osteoclasts and increases bone resorption. Strontium increases osteoprotegerin (OPG), which serves as a decoy for RANKL to slow bone resorption.
Strontium
Increases Our Osteoblasts 01
02
Mesenchymal stem cells (MSC) can become osteoblasts (bone-building cells) or adipocytes (fat cells). Strontium turns on genes that help MSCs become osteoblasts, grow up more quickly, and survive longer.
Strontium
Disrupts Osteoclast Production and Activity 01
02
03
Strontium modulates the maturation of osteoclasts (bone-clearing cells).
Strontium reduces the ability of osteoclasts to adhere to bone and start the bone removal process.
Strontium increases the rate at which osteoclasts commit apoptosis (cell suicide).
Strontium
Strontium Safety In more than 100 years of research (including recent human studies), no adverse effects have been reported for a natural, stable strontium salt when more calcium than strontium is consumed. • Patients with chronic kidney disease (CKD) should avoid strontium. Since strontium is eliminated by our kidneys, it may accumulate in CKD patients whose blood-filtering capabilities are compromised.
AlgaeCal
Meet The Bone Builder Pack The only calcium supplement to increases bone mineral density
What Do You Get With AlgaeCal?
AlgaeCal Plus
Strontium Boost
What Do You Get With AlgaeCal?
Recommended Protocol Based on DEXA Scan YA T-score
1
• To increase BMD if T-score is below -1
0
AlgaeCal Plus or AlgaeCal
2 Normal
- AlgaeCal - Triple Power Fish Oil
-1 Osteopenia
-2 -3 -4
- AlgaeCal Plus - Strontium Boost - Triple Power Fish Oil
Osteoporosis
-5 20
40
60 Age (years)
80
100
AlgaeCal Plus & Strontium Boost
• To maintain BMD if T-score is above -1 Triple Power Fish Oil • To provide omega-3 support for everyone
Dosing Contraindications
Dosing-Contraindications
Dosage Recommendations &
AlgaeCal Plus Take 2 capsules every morning with food
Take 2 capsules every evening with food
Take 2 capsules before bed
Take with or without food, but separate from calcium by at least 2 hours
Strontium Boost
Dosing-Contraindications
Drug Interactions Calcium supplements, including AlgaeCal, should be taken 2 to 3 hours apart from the following drug classes: • Antibiotics • Traditionally-prescribed bone drugs • Some heart medications • Thyroid medications • Water pills • Iron supplements • Strontium supplements
Vitamin K, including K2-7 found in AlgaeCal Plus, may interfere with anticoagulant drugs.
Only AlgaeCal’s Bone Builder Pack is clinically supported to increase bone density in just 12 months. Guaranteed.