AlgaeCal Clinical Overview

Offer Patients a Revolutionary Approach to Build Bone A Clinical Overview of AlgaeCal Formulations

Learning Objectives

Facts About Osteoporosis

Research on Increased BMD

Importance of Calcium

What You Get With AlgaeCal

Why Calcium Alone Isn’t Enough

How Strontium Can Speed Results

How AlgaeCal is Different

Dosing and Contraindications

Facts About Osteoporosis

Osteoporosis Facts

For women over 50, broken bones are more common than heart attack, stroke and breast cancer—combined.

Source: National Osteoporosis Foundation

Osteoporosis Facts

For women over 50, broken bones are more common than heart attack, stroke and breast cancer—combined.

For those over 50 (women and men), 80% of broken bones are caused by bone loss.

Source: National Osteoporosis Foundation

Osteoporosis Facts

The National Osteoporosis Foundation estimates that:

1 in 2 women over 50

&

1 in 4 men over 50

Will suffer an osteoporosis fracture.

Osteoporosis Facts

In the US, 300,000 annual hip fractures cause serious patient consequences.

Six months later, only 15% of patients can walk across a room unaided.

Source: Singer A, et al. Mayo Clinic Proc. 2015;90:53-62

25% Mortality

50% Need Walking Aid

25% Nursing Homes

Osteoporosis Facts

Patients With an Increased Risk of Bone Loss • Gastric Bypass Surgery • Autoimmune Disorders • Certain Cancer Treatments • Digestive & GI Disorders • Blood & Bone Marrow Disorders • Neurological Disorders

Osteoporosis Facts

Patients With an Increased Risk of Bone Loss • Gastric Bypass Surgery

• Menopause

• Autoimmune Disorders

• Perimenopause

• Certain Cancer Treatments

• Andropause

• Digestive & GI Disorders

• Endocrine & Hormonal Disorders

• Blood & Bone Marrow Disorders • Neurological Disorders

Osteoporosis Facts

Other Causes & Risk Factors After the age of 40, we lose about 1% of our bone mineral density every year. The following things can accelerate the loss.

Harmful Diet

Toxins

Diseases

Lifestyle

Osteoporosis Facts

Diagnosis & Testing DEXA Scan YA T-score

2 Normal

1 0 -1

Osteopenia

-2 -3 -4

Osteoporosis

-5 20

40

60 Age (years)

80

100

Recommended for • All women 65+ • All patients with contributing risk-factors

Osteoporosis Facts

Complementary Tests that Help Uncover Root Causes • Omega-3 Index

• Genetic Testing

• Vitamin D

• Intracellular Magnesium Test

• Vitamin K Assay

• 24-Hour Urine Hormone Test

• CTx/NTx Tests

• IgG Food Sensitivity Testing

• Heavy Metals Challenge

• Comprehensive Digestive Stool Analysis

Importance of Calcium

Importance of Calcium

Calcium is the most abundant mineral in our body and plays vital roles in cell, nerve, blood, and muscle functions.

Importance of Calcium

Too many Americans fall short of getting the amount of calcium they need every day and that can lead to bone loss, low bone density and even broken bones.”

— National Osteoporosis Foundation

Importance of Calcium

Pitfalls of Traditional Calcium • Rock-based • Low bioavailability • Safety concerns (lack of supporting nutrients, such as D3 and K2)

Importance of Calcium

Calcium alone will not increase bone density for older people.”

— National Osteoporosis Foundation

Source: Patient Educator, Univ. of Alabama at Birmingham (video on NOF site)

Importance of Calcium

8 6

Calcium alone can’t increase bone density.

Bone Mineral Density

4 2 0

-3%

-2 -4

Traditional Calcium Supplements Traditional calcium supplements can only slow bone loss a little.

-7%

-6 -8 Years

1

2

3

4

5

6

7

On average, we lose 1% of our bone density every year after age 40.

No Supplements Without calcium supplementation, the average person loses 1% of their bone each year.

How AlgaeCal Is Different

Why AlgaeCal?

AlgaeCal Plus contains plant-based calcium, plus over a dozen nutrients bones need. Few can get all of these from diet, especially as we age.

Why AlgaeCal?

Mission Vision

Guided by science and powered by nature, we inspire people to strengthen their bones.

A world without fear of bone loss.

Why AlgaeCal? Our Scientific Advisory Board

Prof. Didier Hans, PhD

Dr. Loren Fishman, MD, PhD

Dr. Carole McArthur, MD, PhD

Head of R&D, Cntr. of Bone Diseases, Lausanne Univ. Hospital CHUV, Switzerland

Med. Dir., Manhattan Physical Medicine & Rehabilitation

Prof. of Immunology, Univ. of MissouriKansas City; Dir., Residency Research in Pathology, Truman Medical Center.

Dr. Liz Lipski, PhD

Lara Pizzorno, MDiv, MA, LMT

Prof. and Dir., Academic Devel., Nutrition Programs in Clinical Nutrition at Maryland Univ. of Integrative Health.

Editor, Longevity Medicine Review; Sr. Medical Editor, Integrative Medicine Advisors; author, Healthy Bones Healthy You!

The Traditional Calcium Problem

8

Bone Mineral Density

6

Calcium alone can’t increase bone density.

4 2 0

-3%

-2 -4

Traditional Calcium Supplements Traditional calcium supplements can only slow bone loss a little.

-7%

-6 -8 Years

1

2

3

4

5

6

7

On average, we lose 1% of our bone density every year after age 40.

No Supplements Without calcium supplementation, the average person loses 1% of their bone each year.

Why AlgaeCal? +7.3%

8

Only AlgaeCal is clinically supported to increase bone density.

Bone Mineral Density

6

AlgaeCal AlgaeCal increased bone density each year for an average of 1.04%, as shown in clinical studies.

4 2 0

-3%

-2 -4

-7%

-6 -8 Years

1

2

3

4

5

6

With AlgaeCal’s formulation, instead of losing 7% in 7 years, your patients are gaining 7.3%. That’s a 14% swing!

7

Traditional Calcium Supplements Traditional calcium supplements can only slow bone loss a little.

No Supplements Without calcium supplementation, the average person loses 1% of their bone each year.

Why AlgaeCal?

AlgaeCal Plus Increases Bone Density.

No other natural product can legally make this claim!

Why AlgaeCal?

AlgaeCal Plus

Traditional Calcium

Increases BMD (bone mineral density)

Clinically supported in 3 human studies

• Can only slow bone loss

Bone-building nutrients

13 minerals and 3 vitamins

• Just 1 to 3 nutrients

Calcium derived from living plants

Red algae (Lithothamnion superpositum)

• Made from crushed rocks

DEXA guarantee

Scan-to-scan improvement after 1 year

• No guarantee

Research On Increased BMD

Study 1 Summary

Nutrition Journal

216 Participants

x10

This study, involving more than 200 women and men found that AlgaeCal formulations increased bone density by more than 2% on average.

> 2% Bone mineral density increases achieved

Study 1 Detail

Nutrition Journal 5.0% 4.5%

Annualized % BMD Changes

4.0%

Comparisons of mean annualized change in bone mineral density from baseline in two groups following the same bone-health plan, but with different formulations of an enhanced plant-based form of calcium.

3.5% 3.0% 2.5% 2.0% 1.5% 1.0% 0.5% 0.48%

0.0%

2.27%

2.18%

2.94%

-0.67%

3.72%

4.33%

-0.61%

-0.5% -1.0% -1.5% -2.0%

AlgaeCal and Strontium Boost

AlgaeCal Plus and Strontium Boost

Both formulas delivered real gains in BMD, though the one using the nutrients in AlgaeCal Plus performed best.

Study 2 Summary

International Journal of Medical Sciences

414 Participants

x10

Up to

This study, involving 414 post-menopausal women found that AlgaeCal formulations increased bone density by 1.3% to 4.1% in one year.

4.1%

Increase in bone density among postmenopausal women

Study 2 Detail

Annualized % BMD Changes

International Journal of Medical Sciences Exp Chng

-0.75%

AlgaeCal

The two groups incorporating strontium citrate show the highest average BMD increases.

1.3%

AlgaeCal and Strontium Boost

2.18%

2.0%

AlgaeCal Plus and Strontium Boost

3.72%

4.1% 4.1%

-1%

0%

1%

2%

3%

4%

5%

Study 3 Summary

Journal of the American College of Nutrition This award-winning study, found that 172 female participants who took AlgaeCal for 7 years saw an average annual bone density increase of 1.04%. That’s 7.3% more bone over 7 years!

172 Participants

x10

1.04% Average annual increase in bone density in women

The AlgaeCal Difference +7.3%

8

Only AlgaeCal is clinically supported to increase bone density.

6

AlgaeCal AlgaeCal increased bone density each year for an average of 1.04%, as shown in clinical studies.

Bone Mineral Density

4 2 0

-3%

-2 -4

-7%

-6 -8

Years

1

2

3

4

5

6

With AlgaeCal’s formulation, instead of losing 7% in 7 years, your patients are gaining 7.3%. That’s a 14% swing!

7

Traditional Calcium Supplements Traditional calcium supplements can only slow bone loss a little.

No Supplements Without calcium supplementation, the average person loses 1% of their bone each year.

What Do You Get With AlgaeCal?

What Do You Get With AlgaeCal?

AlgaeCal A Complete Calcium Source

01 Ocean Algae

03 USDA Organic and Kosher

02 Sustainably Harvested

04 13 Bone-Essential Minerals

What Do You Get With AlgaeCal?

AlgaeCal Plus

More than a dozen nutrients that support increased bone density.

• Calcium • Magnesium • Copper • Manganese • Silicon • Strontium • Nickel • Phosphorous

• Selenium • Vanadium • Zinc • Boron • Vitamin K2 (MK-7) • Vitamin D3 • Vitamin C

What Do You Get With AlgaeCal?

Vitamin D3 Supports Healthy Bones

Reduces Cancer Risk

Reduces Alzhiemer’s Risk

Decreases CV Disease

Protect Against Diabetes

Boosts Immunity

Combats Depression

Reduces Rheumatoid Arthritis

What Do You Get With AlgaeCal?

Magnesium Supports Bone Health

Improves Digestion and Alleviates Constipation Symptoms

Protects Against Diabetes

07 Relieves Insomnia

01

06 Protects Your Heart

02

05 Combats Asthma 04 Reduces High Blood

03

Pressure

What Do You Get With AlgaeCal?

Vitamin K2 (MK-7) Vitamin K2 activates GLA proteins that keep calcium away from your organs, arteries, and soft tissues, and carries it to where you need it the most-your bones!

Helps Prevent Bone Loss

Lowers Risk of Heart Disease

Lowers Cancer Risk

Longevity

Keeps Teeth Strong

Fights Autoimmune Conditions

What Do You Get With AlgaeCal?

Boron Ca

Mg

Helps Build Bone

Maintains Calcium Levels

Maintains Magnesium Levels

Extends Availability Of Vitamin D

Boron lowers osteoclastinducing inflammation and boosts osteoblast activity

Boron cuts the amount of calcium lost in urine by almost 50% and helps put more calcium in your bones

Boron improves your body’s ability to absorb and utilize magnesium

Boron helps men and women get the most bone-building benefit from vitamin D

What Do You Get With AlgaeCal?

Silicon (Orthosilicic Acid) Increases 01

02

03

04

Bone-specific alkaline phosphatase - an enzyme involved in osteoblasts’ boneforming activity

Osteocalcin, the vitamin K-dependent protein that escorts calcium into bones

Osteoblast proliferation and activity

Type 1 Collagen, which is associated with bone strength

What Do You Get With AlgaeCal?

Strontium Boost A natural mineral found in soil and throughout our food supply.

• Increases calcium absorption • Boosts bone formation • Regulates bone breakdown • Reduces fracture risk independent of bone density

Study 2 Detail

Annualized % BMD Changes

International Journal of Medical Sciences Exp Chng

-0.75%

AlgaeCal

Of three test groups, all gained bone density. Plans 2 and 3 included strontium citrate.

1.3%

AlgaeCal and Strontium Boost

2.18%

2.0%

AlgaeCal Plus and Strontium Boost

3.72%

4.1% 4.1%

-1%

0%

1%

2%

3%

4%

5%

How Strontium Can Speed Results

Strontium

Strontium: Boosts Calcium Absorption 01

02

03

Calcium-sensing receptors (CaSR) are found on osteoblasts, the cells that build new bone.

Researchers have identified a new CaSR version that is only activated by strontium.

By activating CaSR, strontium helps increase calcium absorption.

Strontium

Regulates Bone Breakdown The Key Molecules that Control the Rate of Bone Breakdown

01 02

Strontium modulates RANKL, which activates osteoclasts and increases bone resorption.

Strontium increases osteoprotegerin (OPG), which serves as a decoy for RANKL to slow bone resorption.

Strontium

Increases Our Osteoblasts 01

02

Mesenchymal stem cells (MSC) can become osteoblasts (bone-building cells) or adipocytes (fat cells).

Strontium turns on genes that help MSCs become osteoblasts, grow up more quickly, and survive longer.

Strontium

Disrupts Osteoclast Production and Activity 01

02

03

Strontium modulates the maturation of osteoclasts (bone-clearing cells).

Strontium reduces the ability of osteoclasts to adhere to bone and start the bone removal process.

Strontium increases the rate at which osteoclasts commit apoptosis (cell suicide).

Strontium

Strontium Safety In more than 100 years of research (including recent human studies), no adverse effects have been reported for a natural, stable strontium salt when more calcium than strontium is consumed.

• Patients with chronic kidney disease (CKD) should avoid strontium. Since strontium is eliminated by our kidneys, it may accumulate in CKD patients whose blood-filtering capabilities are compromised.

AlgaeCal

Meet The Bone Builder Pack The only calcium supplement to increases bone mineral density

What Do You Get With AlgaeCal?

AlgaeCal Plus

Strontium Boost

What Do You Get With AlgaeCal?

Recommended Protocol Based on DEXA Scan YA T-score

1

• To increase BMD if T-score is below -1

0

AlgaeCal Plus or AlgaeCal

2 Normal

- AlgaeCal - Triple Power Fish Oil

-1 Osteopenia

-2 -3 -4

- AlgaeCal Plus - Strontium Boost - Triple Power Fish Oil

Osteoporosis

-5 20

40

60 Age (years)

80

100

AlgaeCal Plus & Strontium Boost

• To maintain BMD if T-score is above -1 Triple Power Fish Oil • To provide omega-3 support for everyone

Dosing Contraindications

Dosing-Contraindications

Dosage Recommendations &

AlgaeCal Plus Take 2 capsules every morning with food

Take 2 capsules every evening with food

Take 2 capsules before bed

Take with or without food, but separate from calcium by at least 2 hours

Strontium Boost

Dosing-Contraindications

Drug Interactions Calcium supplements, including AlgaeCal, should be taken 2 to 3 hours apart from the following drug classes: • Antibiotics • Traditionally-prescribed bone drugs • Some heart medications • Thyroid medications • Water pills • Iron supplements • Strontium supplements

Vitamin K, including K2-7 found in AlgaeCal Plus, may interfere with anticoagulant drugs.

Only AlgaeCal’s Bone Builder Pack is clinically supported to increase bone density in just 12 months.

Guaranteed.