NewsNotes - Winter 2002

CHILDREN’S DIABETES FOUNDATION AT DENVER — WINTER 2002

15TH CAROUSEL OF HOPE GLITTERS WITH STARS — Hilary Sheldon

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The Carousel of Hope outdid itself once again on October 15th at The

Beverly Hilton when over 100 A-List stars joined music Superstars Elton John, Sting and B.B. King who headlined the entertainment and Jay Leno who again served as master of ceremonies. Sir Sidney Poitier was presented the Brass Ring Award by Academy Award winning actress Halle Berry, who flew in from Canada just for the event.

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Carousel of Hope Ball

All Carousel Ball and Symposium photos: Š Berliner Studios 1

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1. Owen Wilson & David Spade 2. Barbara Davis and Invocation Child Taylor Brandon 3. Raquel Welch 4. Kate Hudson 5. Ray Romano 6. Sir Elton John

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Barbara Davis and Oprah Winfrey Shelby and Tom Arnold Mark Wahlberg Lisa Kudrow Mira Sorvino B.B. King

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Sting Rebecca DeMornay Amy Smart Jessica Simpson and Nick Lachey Harry Hamlin and Lisa Rinna Daryl Hannah Shawn and Larry King

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Frances and Smokey Robinson Matthew McConaughy and Kate Hudson Dr. Phil and Robin McGraw Camille & Kelsey Grammer and Julia Louis-Dreyfus 5 Linda & David Foster 6. Samuel L. Jackson and B.B. King

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Barbara & Marvin Davis Ryan Haddon and Christian Slater Jolene & George Schlatter Robert Graham Lara Flynn Boyle Jay Leno

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1. Dana Davis, Barbara Davis, Bai Ling Christian Slater and Nancy Davis 2. Elizabeth Taylor and Merv Griffin 3. Mathew St. Patrick 4. Candy, Aaron and Tori Spelling 5 Jennifer Flavin and Sylvester Stallone

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Carousel of Hope Ball

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1. Barbara & Marvin Davis 2. Suzanne Somers, Barry Manilow, Clive Davis, Penny Lancaster and Rod Stewart 3. Thora Birch 4. Joanna, Sidney & Anika Poitier 5 Don Rickles, Bob Newhart and Tony Danza

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Penny Marshall Jackie Collins and Barbara Davis Josefa Salinas and Coolio Quincy Jones and Lissette Derouaux Elton John, Elizabeth Hurley and David Furnish

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Oprah Winfrey introduced Chairman Barbara Davis who spoke about the importance of helping children who suffer with diabetes. Singing sensation Josh Groban opened the show by singing the National Anthem and adorable Taylor Brandon, a 4 year-old patient at the Barbara Davis Center, joined Mrs. Davis on stage for the invocation.

The evening’s program included stellar musical performances produced by veteran television impresario George Schlatter with the help of multiple Grammy-winner Music Director David Foster. The Music Committee was chaired by recording industry legends Quincy Jones and Clive Davis.

Major sponsors of this year’s event were Toys “R” Us, Chopard, General Motors & Cadillac, American Airlines, Guess?, Inc. and Merv Griffin’s Beverly Hilton.

Among the countless luminaries who joined forces to help conquer diabetes were Kelsey Grammer, Kate Hudson, Elizabeth Hurley, Samuel L. Jackson, Matthew McConaughey, Ray Romano, Martin Sheen, Jessica Simpson & Nick Lachey, Christian Slater & Ryan Haddon, Mira Sorvino, David Spade, Sylvester Stallone & Jennifer Flavin, Dame Elizabeth Taylor, Mark Wahlberg, Raquel Welch, Owen Wilson, James Woods, Tom Arnold, Jim Belushi, Thora Birch, Lara Flynn Boyle, Wayne Brady, Dyan Cannon, Jackie Collins, Coolio, Tony Danza, Geena Davis, Rebecca DeMornay, Don Johnson, Shannen Doherty, Roma Downey, Shannon Elizabeth, Leeza Gibbons, Robert Graham, Olympian Gary Hall, Jr., George Hamilton, Harry Hamlin & Lisa

Rinna, Daryl Hannah, Marilu Henner, Larry King, Lisa Kudrow, Tara Lipinski, Julia Louis-Dreyfus, Jon Lovitz, Barry Manilow, Penny Marshall, Dr. Phil, Ed McMahon, Donna Mills, Bob Newhart, Gary Owens, Don Rickles, Smokey Robinson, Mimi Rogers, Roseanne, Mathew St. Patrick, Tom Selleck, Nicolette Sheridan, Henry Simmons, Amy Smart, Suzanne Somers, Tori Spelling, Cheryl Tiegs, Jeanne Tripplehorn, Joan van Ark, Montel Williams and Vanna White.

Some 20,000 pink roses individually chosen and flown in from Ecuador graced the main ballroom, where lavish gold carousel centerpieces donated

by Treefrogs decorated each table. The tables were covered in iridescent pink organza with matching chair covers accented by voluminous pink organza bows. During dinner the guests had a chance to bid on four items during the Live Auction, including the brand new XLR Cadillac Sports Roadster donated by General Motors and one-on-ones with Lakers’ superstars Shaquille O’Neal, Kobe Bryant and Rick Fox.

The Silent Auction was chaired

by Dana Davis and Nancy Davis and raised close to $900,000.

The Auction area was a vision in yards and yards of pink and white chiffon carousel canopies.

Over 900 items were featured, including donations from American Airlines, Giorgio Armani, Spago, Tiffany & Co., Chanel, Escada, Northwest Airlines, NetJets, The RitzCarlton Company, Valentino

The Silent Auction also featured over 75 pieces of contemporary art donated by such worldrenowned artists and photographers as Charles Arnoldi, Ross Bleckner, David Salle, Alexandra Nechita, Ed Ruscha, Roy Lichtenstein, George Rodrigue, Kenneth Shorr, Ken Price, Donald Sultan, Kenny Scharf, Cindy Sherman, Julian Schnabel, David Hockney, John Baldessari, Patrick

Demarchelier, Steven Meisel, Agnes Martin, Bert Stern, Robert Rauschenberg, Nancy Ellison, Jenny Holzer, Robert Graham, LeRoy Neiman, Ed Moses, Laddie John Dill, Herb Ritts, Alice Springs, Helmut Newton, William Wegman, Harry Benson, Howard Bingham, Peter Beard, Timothy White, Louise Bourgeois, Greg Gorman, Firooz Zahedi, Nigel Parry and architects Richard Meier and Frank Gehry. Celebrity artists included Tony Bennett, Richard Gere, Jeff Bridges, Henry Winkler, Dennis Hopper, John Lennon, Ringo Starr, Paul McCartney, Sylvester Stallone, Martin Sheen, John Mellencamp and Jane Seymour. A week before the event Sotheby’s hosted a preview of selected pieces at its gallery in Beverly Hills.

The evening was topped off by two fabulous gift bags for each guest which contained items donated by Toys “R” Us, Guess?, Inc., Cadillac & General Motors, Saks Fifth Avenue, MAC, The Walt Disney Company, Mattel,

Inc., Nancy Ellison, Rembrandt, Roots, Christopher Radko, Jackie Collins, Estee Lauder, Newman’s Own Organics, Chopard, Suzanne Somers, Los Angeles Lakers, Bodega Chocolates, The Sports Club/LA, Balanced Health Products, Inc., Swarovski Crystals, Ben Simon Salon, Cold Fusion Foods, Sandra Lee, Peter Thomas Roth, O the Oprah magazine, Equinox Fitness, Miramax Books, Wendy’s, MAG Instruments, Kenneth Cole New York, Victoria’s Secret, J Records and Universal Music Group.

The Children’s Diabetes Foundation would like to thank all of the people who made The Carousel of Hope a huge success including: A Video Affair, A.B. Hirschfeld Press, Adohr Farms Dairy, Berliner Studios, Canon U.S.A., The Coca-Cola Company, The Elite Group Ltd., George Schlatter Productions, Generex Biotechnology, Goodyear Airship Eagle, Jerry Soloman Custom Framing, Mindy Weiss Party Consultants, The Paper Bag Princess, Pernod Ricard, PMK/HBH, Thierry Portoy, Ralph’s Grocery Company, Solters & Digney Public Relations, Sotheby’s and Fred Gibbons and Treefrogs.

Final figures are not yet in, but with over $4.5 million in to date the success of the effort is assured. Funds raised benefit the programs of research and clinical care at the BDC where over 4,000 children and young adults receive the finest diabetes care available in the world. A portion of proceeds is also given to the Los Angeles chapters of the American Diabetes Association and Juvenile Diabetes Research Foundation International.

Carousel of Hope Ball

Couture, David Orgell, MGM MIRAGE, Delta Air Lines, Motorola, Inc., Four Seasons Hotel & Resorts, the Los Angeles Dodgers and the Los Angeles Lakers. Once again the “Celebrity Plates” section drew attention with 56 hand-painted plates decorated by such celebrities as Ben Affleck, Cher, Kelsey Grammer, Jay Leno, Jack, Kelly and Ozzy Osbourne, Arnold Schwarzenegger, Britney Spears, Barbra Streisand, Celine Dion, Madonna, Robert Graham, Oprah Winfrey and Jennifer Lopez. Color Me Mine donated plates, brushes and paints for this amazing project.

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2002 Symposium

THE 2002 SYMPOSIUM: “THE GENOMIC REVOLUTION AND TYPE 1 DIABETES” The 2002 Carousel of Hope Scientific Symposium focused on the emerging technologies of gene discovery that have revolutionized basic research in many biomedical fields and particularly in the discovery of the causes of type 1 diabetes and new approaches for its therapy. Termed “The Genomic Revolution,” it is a radically new way to do research based on our knowledge of the complete DNA sequence of the human being and the development of methods to simultaneously study the 40,000 or more building blocks that make up a living individual.

It will allow us to screen tens of thousands of potential drugs in a single day and tailor medical treatments to the individual’s disease. The Symposium brought together preeminent scientists and clinicians from many different disciplines and countries. Their interests ranged from investigations of the development of the endocrine pancreas, stem cell therapy, discovery of diabetes susceptibility genes, viruses and environmental factors that cause Type 1 diabetes and new approaches to drug development and islet transplantation.

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Thomas F. Bumol, Ph.D., Vice President of Research Technologies and Proteins, Lilly Research Laboratories, a division of Eli Lilly and Company, Indianapolis, IN Dr. Bumol focuses on new 12

biological technologies critical for contemporary drug discovery and bioproduct research at Lilly Research Laboratories. His research interests have spanned several therapeutic areas including investigations into tumor cell biology, inflammation, atherosclerosis and monoclonal antibody technology. His current research interests focus on inflammation and tissue regeneration.

Mark Duncan, Ph.D., Professor, Departments of Pharmaceutical Sciences and Biochemistry & Molecular Genetics; Director, University of Colorado Center Biochemical Mass Spectrometry Facility, University of Colorado Health Sciences Center, Denver, CO Dr. Duncan researches the use of mass spectrometry in biomedical research, and in particular, the rapidly evolving area of proteomics. He focuses on the development of new experimental approaches that enhance sensitivity, quantitative accuracy and qualitative certainty of these techniques and their application to tear chemistry, prostate cancer, diabetes and cystic fibrosis.

George S. Eisenbarth, M.D., Ph.D., Executive Director of the Barbara Davis Center for Childhood Diabetes; Professor, Department of Pediatrics, Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO Dr. Eisenbarth has pioneered studies of the prediction and trials for the prevention of type 1 diabetes. Given genetic susceptibility, patients and their families are at risk for a series of related autoimmune

disorders. A group of children can now be identified at birth with a 50% risk of developing diabetes. With collaborating investigators, he is pursuing immunologic “vaccination” with insulin peptides for diabetes prevention.

Décio L. Eizirik, M.D., Ph.D., Director, Laboratory of Experimental Medicine; Professor, Free University Brussels, Brussels, Belgium Dr. Eizirik presently utilizes microarray analysis to clarify the pattern of gene expression in beta-cells exposed to different pro-apoptotic agents. The picture emerging from these findings is that beta-cells are not passive bystanders of their own destruction. On the contrary, beta-cells respond to damage by activating diverse networks of transcription factors that may either lead to apoptosis or preserve viability.

Satish K. Garg, M.D., Director of the YoungAdult Clinic, Barbara Davis Center for Childhood Diabetes; Professor, Departments of Medicine and Pediatrics, University of Colorado Health Sciences Center, Denver, CO Dr. Garg directs the Young Adult Clinic at the Barbara Davis Center. His research looks at the application of glucose monitoring devices in the shortterm control of glycemia and genetically engineered form of insulins for better management of the short and long-term complications of diabetes.

2002 Symposium

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2002 Symposium

Mark Geraci, M.D., Associate Professor, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO Dr. Geraci is the Director of the Gene Expression Facility of the UCHSC and involved in the development of all aspects of the Facility and its application in many areas of medical investigation including the discovery of genes involved in pancreas development, pathogenesis of diabetes and diagnostics of pulmonary and malignant diseases. The UCHSC facility is currently the largest academic user of Affymetrix arrays in the United States.

Michael S. German, M.D., Associate Professor in Residence Department of Medicine and Hormone Research Institute, UCSF, CA; Associate Director, UCSF Diabetes Center, San Francisco, CA The central focus of Dr. German’s laboratory is the pancreatic beta-cell and the cascade of gene activation underlying the development of the beta-cells from less differentiated cells during embryogenesis. His work aims to translate our knowledge of the beta-cell into novel strategies for curing diabetes.

Background photo: © Martin Crabb

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John C. Hutton, Ph.D., Research Director, Barbara Davis Center for Childhood Diabetes; Professor, Departments of Pediatrics and Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, CO Dr. Hutton is an authority on the mechanism of insulin secretion from the pancreatic beta-cell.

His research team studies the proteins of the islet that become targets of autoimmunity in type 1 diabetes as well as other components of the beta-cell that will become the basis of creating new insulin secreting tissue for future diabetes therapies.

Jan Jensen, Ph.D., Member, Research Division, Barbara Davis Center for Childhood Diabetes; Assistant Professor of Pediatrics, University of Colorado Health Sciences Center, Denver, CO Dr. Jensen is one of the most recently recruited members of the Barbara Davis Center. His work is focused on understanding the nature of pancreatic stem cells seeking to harness these cells as a beta-cell source for therapy of diabetes. His research efforts take root in the developmental biology of the embryonic pancreas, integrating this knowledge in his studies of cells having a stem cell character in the adult organ.

Klaus Kaestner, Ph.D., Assistant Professor, Department of Genetics, University of Pennsylvania, Philadelphia, PA Dr. Kaestner is interested in the identification and analysis of the regulatory, or “Master,” genes that control the development and function of the pancreas, liver and gut. These genes often encode for transcription factors that control the activity of whole sets of target genes in a given tissue.

W. Ian Lipkin, M.D., The Louise Turner Arnold Chair in Neurosciences and Director of the Emerging Diseases Laboratory at the University of California, Irvine, CA. Laboratory for Immunopathogenesis and Infectious Diseases in The Mailman School of Public Health and the Center for Integration of Neuroscience and Child Health, Columbia University, New York, NY Dr. Lipkin is an authority on the use of molecular biological methods for pathogen discovery and the role of immune and microbial factors in neurologic and neuropsychiatric diseases.

Mark Nicolls, M.D., Assistant Professor, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO Dr. Nicolls research focuses on transplantation immunology and the development of improved methods for clinical islet transplantation. He uses proteomic science to better understand how pancreatic islets function.

Marian J. Rewers, M.D., Ph.D., Clinical Director of the Barbara Davis Center for Childhood Diabetes; Professor, Department of Pediatrics and Preventive Medicine, University of Colorado Health Sciences Center, Denver, CO Dr. Rewers researches prevention of diabetes and its complications. His “Diabetes Autoimmunity Study in the Young” has tested over 25,000 newborns for diabetes genes and followed 1,200 of those and 800 infant relatives of diabetic persons to identify environmental factors that cause autoimmunity and diabetes.

Camillo Ricordi, M.D., Professor, Department of Surgery; Chief, Division of Cellular Transplantation Scientific Director, Diabetes Research Institute, University of Miami School of Medicine, Miami, FL

Jin-Xiong She, Ph.D., Professor and Eminent Scholar in Genomic Medicine; Director, Center for Biotechnology and Genomic Medicine; Vice Chair, Department of Pathology; School of Medicine, Medical College of Georgia, Augusta, GA Dr. She’s research focuses on the elucidation of genetic and immunological mechanisms of human diseases, particularly autoimmune type 1 diabetes.

The experimental approaches include genetic mapping and positional cloning of disease genes, functional genomics, proteomics, creation and analysis of animal models for human diseases.

Lori Sussel, Ph.D., Member, Research Division, Barbara Davis Center for Childhood Diabetes; Assistant Professor, Departments of Pediatrics and Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, CO Dr. Sussel is a developmental biologist studying the transcriptional regulation of pancreas development in the mouse embryo. Her recent efforts have focused on an essential pancreatic regulatory factor, Nkx2.2. She is using genomics to understand how the mouse islet develops in the presence and absence of Nkx2.2.

Dr. Ricordi’s major research interest is in pancreatic islet cell transplantation and in the development of methods to induce islet graft acceptance without the requirement for long-term recipient immunosuppression.

2002 DAVIS AWARD

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Donald F. Steiner, M.D., Professor, Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL

Dr. Steiner studies the cellular and molecular biological mechanisms underlying the production and action of insulin and related metabolic/growth regulatory hormones. The mechanisms of proteolytic processing of precursor proteins and the evolution of insulin-like hormones and their receptors are related topics of interest.

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Barbara Davis Center

NEW 10th EDITION OF PINK PANTHER™ BOOK IS HOT OFF THE PRESS The 10th edition of Understanding Diabetes became available in September. There are many updates and additions to this edition which are listed below. Dr. Chase told the health professionals at the Keystone Conference that this is the best ever and he does not think that he will ever have to do another update (He always says that).

Fifty thousand copies were printed as opposed to only 40,000 of each of the previous four editions. The printing of the Pink Panther™ book is a way to reach out to more families over the 4,000 that are followed by the Pediatric and Young-Adult Clinics at the Center. The book can be ordered by calling Lisa at the Foundation office at 303863-1200 or by mailing a copy of the order form to Children’s Diabetes Foundation, 777 Grant Street, Suite 302, Denver, CO 80203. Please remember that all orders must be pre-paid before shipping.

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3. Chapter 4: A new chapter on Type 2 Diabetes. All other book chapters have been altered to be inclusive of and address Type 2 diabetes issues.

4. Chapters 5 and 15: Include use of the new blood test for ketones (B-OH butyric acid).

5. Chapter 6: Instructions for administration of low-dose glucagon when the blood sugar is low and food cannot be kept down.

6. Chapter 7: Alternate site (e.g., arms) blood sugar testing.

The importance of doing blood sugars after meals is now emphasized.

7. Chapter 8: A new and expanded section on Lantus insulin (insulin glargine).

8. Chapter 11: Desired cholesterol and lipoprotein levels for people with diabetes are in Table 1.

9. Chapter 12: An expanded section on carbohydrate counting is now included.

10. Chapter 17: New sections on needle phobia, depression and eating disorders.

11. Chapter 19: A new section on hypoglycemia and driving a car for people with diabetes.

12. Chapters 21 and 26: Recommended “correction” insulin doses are now included.

13. Chapter 23: New School Intake, School Care and School Emergency Plans.

14. Chapter 27: A new chapter on Pregnancy and Diabetes.

15. Chapter 28: Inclusion of current results from the Edmonton islet transplant research and update on DPT-1.

IMPORTANT CHANGES AND ADDITIONS TO THE 10TH EDITION 1. The text of all chapters has now been adjusted to an 8th grade reading level. All chapters have been updated, reorganized and formatted to enhance understanding.

2. Topics and Teaching/Learning Objectives have now been added to the beginning of each chapter to incorporate American Diabetes Association (ADA) curriculum guidelines.

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The Pink Panther™ & © 2002 UNITED ARTISTS CORPORATION. All rights reserved.

BOOK ORDER FORM Name _____________________________________________________________________________________________ Address ____________________________________________________________________________________________ City/State/Zip ______________________________________________________________________________________ Phone (Day) _____________________ Phone (Eve) _____________________ Email _____________________ Understanding Diabetes $18 per copy (includes shipping and handling) ______ Quantity Managing and Preventing Diabetic Hypoglycemia (Video) $20 per copy (includes shipping and handling) ______ Quantity A Book for Coloring and Learning About Diabetes $5 per copy (includes shipping and handling) ______ Quantity A First Book for Understanding Diabetes (Spanish) $7 per copy (includes shipping and handling) ______ Quantity

Kid’s Cupboard - Chock full of treats for all ages $10 per copy (includes shipping and handling) ______ Quantity Make checks payable to: The Guild – CDF at Denver Visa, MasterCard and Discover accepted.

All orders must be paid in full before delivery. Books are shipped ground UPS – allow 1 to 3 weeks for delivery.

Canadian and Foreign Purchasers: Please include sufficient funds to equal U.S. currency exchange rates and international postage.

For additional information call 303-863-1200 or 800-695-2873 or visit www.ChildrensDiabetesFdn.org Mailing address: The Guild of the Children’s Diabetes Foundation 777 Grant Street, Suite 302 Denver, CO 80203

BDC NAMED ONE OF TEN NATIONAL ISLET CELL RESOURCE CENTERS — George S. Eisenbarth, M.D., Ph.D.

The National Institutes of Health (NIH) is sponsoring a number of collaborative efforts to foster islet cell transplantation in man.

The Immune Tolerance Network

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and the Islet Cell Resources Centers of the NIH are providing an infrastructure to speed developments in this area. The Barbara Davis Center is one of ten nationally chosen Islet Cell Resource Centers, where the goal is to provide islets for transplantation and research.

Dr. Ronald Gill, a pioneer of basic research in islet transplantation, heads the ICR Center at the BDC and heads a group of physicians and scientists isolating human islets for clinical transplantation.

Seven of the Islet Cell Research Centers are also participating in a specific research islet

transplantation protocol of the Immune Tolerance Network.

Faculty of the BDC provide the islet auto antibody testing core for the Immune Tolerance Network, and Dr. Eisenbarth is a co-chair of the autoimmunity subgroup of the Immune Tolerance Network. There are a number of important hurdles in the development of islet transplantation as a practical procedure in man, but there is considerable optimism generated by recent developments that protocols stemming from basic research will be tested in man.

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Barbara Davis Center

TROUBLE SHOOTING AND YOUR ULTRA AND INDUO METERS

reset the proper time and date.

If after setting the proper time and date, you see - - - , the code must be reset. The readings that are done after resetting the meter will be accurate, but the memory may not be in the correct order.

— DeAnn Johnson, RN

If the meter shows Error code ER4 – A. The meter is out of the recommended temperature range (43°-111° F or 6°-44° C).

B. There is a problem with the test strip: it moved during the test or was damaged.

C. Improper blood sampling.

Battery Problems: A. When the meter loses power for any reason it will enter the setting mode. The meter will display a flashing “12 a.m.” for a time, when it was previously set properly. You will need to

B. Please contact LifeScan Customer Services. English (1-800-227-8862) Espanol (1-800-381-7726).

Reference: “Important New Information About Your One Touch® Ultra METER.” LifeScan, Inc. 2000, Rev. 4/02 If it is convenient, you may get a replacement meter at the BDC when battery problems occur.

LifeScan is being proactive with the information and predicts less than 2% of the meters will have any problems.

SAN DIEGO AREA PROFESSIONALS VISIT THE BDC Dr. Lou Linerelli and Ms. Sara Johnson, RD visited the BDC from San Diego in April to see how the Center runs. Dr. Linerelli is a pediatric specialist who has done much to raise the level of diabetes care in the San Diego area. Ms. Johnson is a dietitian who is on the insulin pump herself and does many of their pump starts. Aventis Pharmaceuticals, Inc. sponsored their visit.

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2003 CALENDAR TO RAISE FUNDS FOR DAISY STUDY AND DIABETES RESEARCH Hannah Publications is a non-profit, taxexempt 501(c)3 organization named after the founder’s daughter, who is both diabetic and has Down Syndrome. As a way to give back to the community that has supported them, and as a way to help raise funds for diabetes research, Hannah Publications was founded. The purpose of the calendars is to show that those with diabetes have active functioning lives. It is a source of encouragement for parents and children with diabetes to see kids and professionals participating in daily activities.

Calendars are $9.95 each plus tax and shipping. To order a calendar please see www.hannahpublications.com.

Otherwise you may stop in the DAISY Study at the BDC to purchase a calendar.

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$ URGENT MESSAGE:

EMLA cream was taken off the market on November 15, 2002, according to AstraZeneca. EMLA is an anesthetic cream often used prior to pump catheter tubing insertions. It is also used prior to blood draws to numb the area where the vein will be punctured. EMLA was taken off the market because the packaging did not meet the Poison Prevention Packaging Act. The company plans to redesign the packaging and get approval by mid-2003.

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Until EMLA is approved for use by the public, it will only be available for in-hospital use.

EMLA will not be available at pharmacies or to physicians for use in their offices.

Ela-MAX, another topical anesthesic, may be considered as an alternative. Ela-MAX information is available at: http://www.ferndalelabs.com/inc/ frameset.asp?page=professionals/ elamax.asp Ela-MAX may be available overthe-counter at your local pharmacy in the topical product section. This product numbs the skin in about 15-45 minutes and has similar properties to EMLA cream.

CHASE ENDOWED CHAIR NOW UP TO $430,000.00 The endowed chair in honor of Dr. Chase, the first (and only for the first three years) full-time physician at the Barbara Davis Center, is continuing to progress.

Contributions have been made from 227 families and have ranged from $10.00 to $30,000.00. In addition to contributions from families, a portion of the sale of the Pink Panther™ books goes to the Chair. The profit from the biennial Keystone Conference for diabetes care providers also goes to the Chair. Dr. Chase has been the director of the first seven conferences. The value of the Chair will be that it is much easier to attract a top-level

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physician if a “Chair” has been established to pay the person’s salary. It is also an honor to have one’s name attached to an ongoing Chair. The University generally requires that a million dollars be in the endowment prior to activating the Chair.

Families who have not yet contributed may fill out the form below and send to the Foundation Office. Donations are tax deductible.

ENDOWED CHAIR FOR THE CLINICAL DIRECTOR AT THE BDC Name ____________________________________________________ Address __________________________________________________ City _____________________________ State ______ Zip __________ Amount ___________________________________________________ Gift in Honor of: Name ____________________________________________________ Address __________________________________________________ City _____________________________ State ______ Zip __________ Amount ___________________________________________________ Additional copies desired ________________________ (Make checks payable to “Chase Endowment Fund”) Please return your contribution with this form to: Children’s Diabetes Foundation 777 Grant Street, Ste 302 Denver, CO 80203

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Questions & Answers

QUESTIONS AND ANSWERS — H. Peter Chase, M.D.

We are considering an insulin pump for our son. Do HbA1c levels (glucose control) always improve in pump users?

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That is a good question. Our initial publication (Pediatrics 107:351356;2001) found that one-third of people improve their HbA1c, one-third stay the same and one-third worsen. The main reason the one-third worsen relates to forgetting to bolus with meals. The "basal" insulin is very flat in activity and does not provide any peaks for meals.

Thus a bolus must be taken (including at least part of the dose prior to the meal) or the blood sugar level will go very high. It is our "clinical" impression that if one bolus per week for a meal is missed for 3 months, the HbA1c will be onehalf point higher (or 2 boluses per week = a full point higher).

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This is discussed on page 281 (Chapter 26)in the new 10th edition of the Pink Panther™ book.

My daughter seems to have a “knack” for losing things.

With insulin pumps being so expensive is it possible to get insurance to replace it if it gets lost?

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One of the families has looked into this.

They found that many homeowners

insurance policies would not insure medical equipment.

However, they did find that one policy called “CHUBB” would.

They had to change their homeowners policy to the company but they were then able to purchase a “rider” for $23.00 a year to insure their child’s pump.

If she will be living in the dorms where she will be in close proximity to other students then yes, she definitely does need to get the vaccine. If she will be living offcampus in an apartment or house then the vaccine is not required.

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My daughter is going to college in the Fall. Does she need to get the (menigococal) meningitis vaccine?

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Photo: © Martin Crabb

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Some of you coming to the BDC for appointments from the cities south of Metro-Denver may not be aware of major construction work taking place on I-25. This construction work is called T-REX and will be causing significant traffic delays on I-25 for several years! If you are planning to use I-25 to get to the Center, you may have to plan for additional time – as much as 45 minutes in some cases. You may want to choose an alternate route to arrive at the Center on time for your appointment. If you have computer access to the Internet you may want to check mapquest.com.

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///////////// WALKING TOWARD A CURE BDC patients and their families gathered together to take part in the 2002 ADA Sponsored America’s Walk for Diabetes on September 21st.

Kristi Parisi’s (front center) family sent Dr. Chase (back row) this photo. The year’s BDC team t-shirt, designed by Yael Gottlieb, featured a tiger with the phrase “Catch the Cure.”

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SPORTS 1 DIABETES 0 Kelly Rheem, who has Type 1 diabetes, is a member of the Nebraska Women’s Soccer Team. During a break in the Nebraska vs. CU game in Boulder she stopped to chat with Dana Feeney, Dick Summerfield and his daughter Sally. Dana, who is 10 years old, has Type 1 diabetes and plays soccer in Boulder during the Fall and Spring. She is also on the Manta Ray’s summer swim team, plays basketball and enjoys gymnastics.

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Winner’s Circle

TRAVELING WITH T-REX

Dick also has Type 1 diabetes and is the owner of Verlo Mattress Factory Stores of Colorado. He coaches Dana and Shelly’s soccer team and enjoys participating in Iron Man Distance Triathlons. He was also on the Med Staff of the ADA-sponsored diabetes camp this past summer.

They don’t let diabetes stop them from enjoying sports…way to go guys!!!

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Winner’s Circle

butter/jelly sandwich. Numerous other hikers joined us at the top. The peak in the near distance in the accompanying picture is Torreys Peak (14,267’). Jon’s dad, Greg, took that peak on, as the kids and I headed back down.

MAKING A DIFFERENCE Miss Emma Pierce (above) presented Dr. Chase with checks contributed to the BDC in honor of her grandmother, Mrs. Joan Struck, who was recently married.

Thank you and congratulations to the happy couple!

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HAPPY HOLIDAYS! Madison Harrod, age six, and a patient at the BDC since age 11/2, designed a holiday card and submitted it to the Juvenile Diabetes Research Foundation International’s 2002 Holiday Card Program. At the time of submission, Madison’s mom told her that only 15 cards would be selected. Madison responded by saying, “Mom, it doesn’t matter if I win, I’m just having fun making the card!” Well, Madison’s design was one of the 15 chosen from over 100 entries received from around the country. You can check out her design by going to www.morethancards.com and clicking on: View 2002 Holiday Cards; then scrolling down to number 14 – Christmas Morning.

WE ARE ALL SO PROUD OF YOU MADISON! CONGRATULATIONS!!!

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AIN’T NO MOUNTAIN HIGH ENOUGH Michelle Petruska sent in the following piece about her family’s hike up Grays Peak: Jon Petruska is my son. He, his dad Greg, 13 year old sister Caitlin and I, climbed the “Fourteener” Grays Peak (14,267’) on September 1, 2002.

We hit the trailhead about 8:30 a.m. and “peaked” at about 11:30. We had lots of snacks along the way (gorp, juice, Tiger Bars) and lots of water. It was chilly, as the trailhead is at 11,230’, higher than most day hikes, so we brought lots of layers, gloves and hats. Lunch at the top was simple, a peanut

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This was the first fourteener for all of us. Jon and family had been preparing for a fourteener this summer by hiking 2 tenmile hikes, Byer’s Peak (12,000+), and numerous shorter hikes. Nothing can prepare you though for the effect of the lack of oxygen on tired legs! Jon was one of the youngest hikers we saw on the Grays Peak trail that day. Quite an accomplishment for a youngster, let alone one diagnosed with Type 1 diabetes just two years ago. We of course, were well prepared for the hike, with Jon’s test kit, insulin, snacks, lots of water and lunch.

QUILT ARTIST

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Chelsea Dyke has been seen at the BDC since her diagnosis in 1995 at age 11. Thanks to the friendly and dedicated staff at the Center she has realized that diabetes will not get in the way of her dream of becoming a quilt artist.

As a thanks to Barbara Davis and the Center, Chelsea and her sister Kashia, designed and made a twin size quilt with 15 photos of the Center, the Davis’ and of course children, that was auctioned at the Brass Ring Luncheon on November 5th.

If you are interested in a personal photo quilt or a traditional quilt you can contact Chelsea and her family at Customized Quilting Embroidery Sewing Services (CQESS) 303-979-7169 in Morrison, Colorado.

— Pat Lansing and Susan Greenwald, Co-chairwomen

Our annual mailing of the diabetes education packet was sent in September to all Colorado public and private schools. This year’s mailing included copies of the 9th edition of the Pink Panther™ book (Understanding Insulin Dependent Diabetes), and another opportunity for the schools to request our free diabetes symptoms bookmarks (printed in both English and Spanish).

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We are grateful to Safeway store pharmacies for displaying our bookmarks on their counters.

GUILD MISSION STATEMENT The Guild of the Children’s Diabetes Foundation at Denver raises funds for clinical and research programs for the Barbara Davis Center for Childhood Diabetes.

The Guild promotes diabetes awareness and education; assists families in need; provides continuing education scholarships and sponsors social activities for children and their families.

CHARLOTTE TUCKER SCHOLARSHIP RECEPTION An award reception was held in honor of the 2002 Charlotte Tucker Scholarship recipients on Tuesday, June 4 at the home of Charles and Judy McNeil.

Reception chair Scottie Iverson arranged a lovely evening affair well attended by honorees, their

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families and Guild members.

Forty scholarships in the amount of $1,250 each were awarded to patients from the BDC. Helen Hanks, 2002 Guild President welcomed and congratulated the students.

Award certificates were then presented by Marty Jensen, Charlotte Tucker Scholarship Chair and formerGuild President.

Guild Guide

EDUCATION AND PUBLIC AWARENESS COMMITTEE UPDATE

Each student spoke briefly, and all attending had a great time

Thanks also to Colorado Parent magazine for printing the symptoms in a June article.

Please check out our website ChildrensDiabetesFdn.org (under “Education” and “Tips for College Students”) to see information for young people with diabetes going off to college or living on their own.

Coming soon: “Dating, Engaged, Married.” This information is geared to the person with diabetes who is ready to tell his or her boyfriend or girlfriend about life with diabetes. There are suggestions through testimonials from young women who dated men with diabetes, including one who is now married to him.

Some of the 2002 Charlotte Tucker Scholarship recipients from left; Lindsey Frederics, Leah Mullins, Ryan Ness, Matthew Todd, Danelle Degurie, Michael Wright, Gina Like, Jeff Steinfurth, Laurie Matson, Jeffrey Farr, Elliott Ferneau, John Carporter, Eric Adler and Josh Isackson.

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CHARLOTTE TUCKER SCHOLARSHIPS AWARDED Each year The Guild awards scholarships to high school seniors or college students. In 2002, 40 scholarships were given in the amount of $1,250 each. The scholarship program was established in memory of former Guild President, Charlotte Tucker who encouraged young people from the Barbara Davis Center to follow higher career and/or educational pursuits. Applications for 2003-2004 will be available in February 2003. Patients who are college age (17-23) will be notified on how to receive an application in January 2003. If you don’t receive information then, please call Susie Hummell at the CDF office at 303-863-1200 or 800-695-2873.

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Erik Adler University of Colorado

Robert Anderson Montana Tech

Adam Bankston Colorado State University

John Carpenter Colorado State University

Christy Carroll Metro State College Denver

Lilly Carson Heartland Baptist College

Jamie Decker University of Montana

Danielle DeGarie Colorado State University

Jeffrey Farr Colorado State University

Andrew Feeney Midland Lutheran College

Lindsey Frederics Creighton University

Kelsey Gabrian Montana State University

Kristin Grubb Montana State University

Charles Harvey University of Montana

Jamie Heintz S. Connecticut State

Lisa Hersrud Northwest College-Wyoming

Rockwell Hinkle Montana State University

Joshua Isakson University of Colorado

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Jessica Johnson Santa Clara University

George Joiner Miami University-Ohio

Joshua Kroonenberg Red Rocks Community College

Renzi Lee Methodist College

Gina Like Mira Costa College

Venessa Martinez Westwood Technology

Laurie Matson University of N. Colorado

Amberly Mitchell Colorado State University

Leah Mullins University of Colorado-Denver

Amanda Nelson - Front Range Community College

Ryan Ness Colorado State University

Rachel Ostler - Brighan Young University, Idaho

Misty Owens - Pensacola Christian College

Jennica Schenck Wesleyan College

Jeff Steinfurth University of Colorado

Holly Taylor University of North Dakota

Matthew Todd Fort Lewis College

Drew Widetich University of Colorado-Denver

Michael Wright University of Colorado

Amy Yeager Mesa State College

No photos available: Gabe Adams, Institute of Audio Research • Elliott Ferneau, Northwest Kansas Technical College

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DAY AT THE ROCKIES “Day at the Rockies” provided 750 BDC patients and their families with a fun-filled free day at the ballpark. The children were able to attend a pre-game tailgate party and enjoy goody bags from our many sponsors which included: AllWays Valet, Aramark Corporation, Colorado Rockies Baseball Club, Fifty 50 Foods, Frito-Lay, Stretch Island Fruit and TCBY. Thank you to all of the volunteers who worked at the pre-game party and a special thank you to Chairman Sally Newcomb for organizing this grand slam of an event.

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Photo: Linda Morris

A WICKEDLY WONDERFUL TIME HAD

BY ALL Kids dressed up as princesses, cheerleaders, action figures and cowboys at this year’s Guild Halloween party at the Colorado School of Mines Green Center hosted by Phi Gamma Delta Fraternity. The fraternity has hosted The Guild’s Annual Halloween party since 1983, offering an alternative to the large quantity of sweets offered on this holiday.

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The children enjoyed plentiful amounts of pizza from Domino’s and diet soda from Pepsi-Cola Bottling Company. They had a “spooktacular” time decorating pumpkins (supplied by Guild 26

Carousel Days

Photo: Linda Morris

members Robert and Judy Villano) and played a variety of games, loading their prizes into their overflowing goody bags.

A special appreciation is expressed to Event Chairman, Kathy Crapo, Co-Chairman Judy McNeil and the Halloween Committee who worked so hard putting this event together. It was a ghoulishly great time!

— Markey Swanson, RD, CDE & Gail Spiegel, MS, RD, CDE

The holidays are upon us, and what to do about those endless goodies as “visions of sugarplums dance through our heads?” Keep in mind, this is NOT just an issue in diabetes management, but a matter of how to maintain a nutritious food intake AND allow for fun with holiday food.

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We have known for many years that sugary foods do not raise blood sugar any higher than starchy foods, but many people still worry about how these foods will affect their blood sugar. Keep in mind that the most important factor affecting your blood sugars in foods is the total carbohydrate you eat not the kind of carbohydrate. And knowing how to balance your insulin with total carbohydrate intake will help keep your blood sugars in target range.

Does this encourage you to eat unlimited amounts of carbohydrate in the form of sugar? NO! That is not a

healthy approach to eating. No one, with or without diabetes, should consume large amounts of carbohydrate calories from foods high in added sugar. On the other hand, it is appropriate to have a piece of fudge or a sugar cookie as the occasion presents itself.

Another factor to consider during the holiday season is the FAT content of food choices.

Unfortunately, many of the “goodies” you consume at festive holiday occasions will contain lots of SUGAR and FAT. Parents can be good role models during the holidays by providing fun and healthy food choices and activities. Variety is the key and the decision to have smaller portions of less healthy snacks should be modeled for children.

Note below the list of favorite holiday goodies, portion sizes and corresponding amounts of fat and carbohydrate.

For all individuals at the holiday season it is important to eat healthfully, as you usually do.

When you make a choice to have goodies, keep the amounts within reason. For children with diabetes, estimated amounts of carbohydrate should be

consistent with your normal intake. Above all DO NOT FEEL GUILTY about your food choices.

Remember too, there are occasions when it is appropriate to take extra Humalog® or Novolog® insulin. Your special holiday meal will most likely be larger than normal. Discuss with your care providers the possible need for extra insulin prior to your meal if you are not sure what to do.

Younger children will most likely not require extra insulin for the occasional treat or holiday meal.

Excitement levels are often high and activity levels are extremely unpredictable. Additional carbohydrate may be needed to provide energy for extra activity.

It is important to stay active at this time of year. Regular activity will help burn off those extra calories from treats, keep your blood sugars in target range and your heart healthy.

Cutting down on the amount of time your family spends watching TV and videos or playing on the computer will also help. Below are some ideas of activities the whole family can do inside or outside the house.

Nutrition News

VISIONS OF SUGARPLUMS…

◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆ EVERYDAY ACTIVITIES

AEROBIC ACTIVITIES (3-5 TIMES PER WEEK)

Take stairs instead of the elevator

Skating

Take dog or brother/sister for walk

Skiing/Snowboarding

Pick up your toys

Snowshoeing

Help around the house

Sledding

Walk to store or around the mall

Tubing

Play outside

Dancing Jumping rope

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Cooks Corner

HAPPY HEALTHY HOLIDAY EATING FROM YOUR BDC DIETITIANS! HOLIDAY GOODIES CARBOHYDRATE

FAT

1 peppermint candy or 1 small candy cane

5-8 gms

0 gm

1 piece fudge with nuts (1 oz)

20 gms

4 gms

1 slice holiday bread (Approx. 1/15 of a 9x5” loaf)

20-25 gms

5 gms

15 gms

5 gms

1 sugar cookie, homemade!

3” size

PARTY MIX Preheat oven to 250º INGREDIENTS: 1/4 cup margarine

HOT SPICED TEA MIX

21/2 teaspoons soy sauce

INGREDIENTS: 1-1/4 cups instant tea, plain

1/4 teaspoon garlic powder

1 package (1.8 oz.) sugar free Tang®

1 cup pretzels

1 package (1.8 oz.) sugar free lemonade

1 cup peanuts

2 teaspoons cinnamon

2 cups each Corn Chex, Wheat Chex and Rice Chex

1/2 teaspoon nutmeg DIRECTIONS: Store in tightly covered container. Mix until well blended. Use 1 heaping teaspoon in 1 cup boiling water (Add no caloric sweetener to taste).

NUTRITION INFORMATION: FREE!!!

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1 teaspoon seasoned salt

DIRECTIONS: Melt margarine and add salt, soy sauce and garlic powder.

Toss with remaining ingredients. Place in roaster pan in 250º oven for 15-20 minutes, stirring occasionally to mix.

NUTRITION INFORMATION PER SERVING: Serving Size: 1 cup Per Serving: Calories: 135 Carbohydrate: 18 gms Fat: 6 gms

NO EGG NOG - Janice Knapp

INGREDIENTS: 1 package (four serving size) sugar free instant vanilla pudding mix 4 packets Equal® 7 cups skim milk 1/2 teaspoon nutmeg 1 twelve ounce can evaporated skim milk 2 teaspoons imitation rum flavor extract DIRECTIONS: In half gallon pitcher or large deep bowl, combine pudding mix and Equal® and 2 cups milk. With wire whisk or electric mixer, mix completely for approximately one minute. Add 3 more cups of milk and continue to mix. Add nutmeg, evaporated milk, rum flavor extract and remaining milk. Mix again and chill several hours.

NUTRITION INFORMATION PER SERVING: Number or Servings: 8-10

Look for the 2002 Brass Ring Luncheon article and photos featured in our next newsletter!

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Serving Size: 8 ounces Calories: 125 Carbohydrate: 19 gms Protein: 11 gms Fat: .5 gm

BDC is looking for volunteers.

To learn more please contact the BDC at 303-315-8796

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7TH BIENNIAL KEYSTONE CONFERENCE A RESOUNDING SUCCESS — H. Peter Chase, M.D.

The evaluations from the 350 attendees at the Center’s 7th Biennial Keystone Conference have been analyzed and show that all considered it was a great meeting! This year’s conference provided a forum to update doctors, nurses dietitians and psych-social staff on “Management of Diabetes in the Youth.” Healthcare professionals from every state,

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including Hawaii and Alaska, as well as four people from Chile attended the event.

The conference provides a venue to extend many of the coreprincipals from the BDC to care providers throughout the U.S. It is the only conference in the country to focus exclusively on the care of people with Type 1 diabetes. Planning has already begun for the next conference to be held in July 2004. Dr. William Tamborlane from Yale University has already agreed to be one of our guest speakers.

These important conferences could not be done without the excellent help of Sue Palandri and Linda Schneider from the Children’s Diabetes Foundation.

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EXECUTIVE BOARD: Mrs. Marvin Davis, Chairman Richard S. Abrams, M.D. Jules Amer, M.D. Miss Amy Davis Ms. Dana Davis Mrs. Nancy Davis-Rickles Mrs. Janet Elway Steven Farber, Esq. Mr. Gerald S. Gray Mrs. A. Barry Hirschfeld M. Douglas Jones, Jr., M.D. Richard D. Krugman, M.D. Dean, School of Medicine, University of Colorado Health Sciences Center Mr. Arnold C. Pohs Ex-officio Member: George S. Eisenbarth, M.D., Ph.D. Executive Director, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center; Professor of Pediatrics and Medicine, University of Colorado School of Medicine

SCIENTIFIC ADVISORY BOARD: Richard S. Abrams, M.D. Associate Clinical Professor of Medicine, University of Colorado School of Medicine; Rose Medical Center, Denver Jules Amer, M.D. Clinical Professor of Pediatrics, University of Colorado School of Medicine; Partner, Children’s Medical Center, Denver M. Douglas Jones, Jr., M.D. Professor and Chairman, Department of Pediatrics, University of Colorado School of Medicine; Pediatrician-in-Chief, The Children’s Hospital, Denver Brian Kotzin, M.D. Professor of Immunology, University of Colorado School of Medicine; National Jewish Center for Immunology and Respiratory Medicine, Denver Aké Lernmark, M.D., Ph.D. Robert H. William Professor, Department of Medicine, University of Washington School of Medicine, Seattle Ali Naji, M.D., Ph.D. J. William White Professor of Surgery, Hospital of University of Pennsylvania, Philadelphia

Gerald Nepom, M.D., Ph.D. Scientific Director and Director of Immunology and Diabetes Research Programs, Virginia Mason Research Center, Seattle William V. Tamborlane, M.D. Professor of Pediatrics, Yale University School of Medicine, New Haven, Connecticut

ADVISORY BOARD: Mrs. Alan Angelich Mr. and Mrs. Rand V. Araskog Mrs. John Aylsworth Mr. Michael Bolton Mrs. Joseph Broughton Mrs. Franklin L. Burns Sir Michael Caine The Honorable Ben Nighthorse Campbell, U.S. Senate, Colorado Ms. Natalie Cole Mr. Phil Collins Mr. Lodwrick M. Cook Mrs. John Cowee Mr. and Mrs. Robert A. Daly Mrs. Thomas P. D’Amico Mr. Tony Danza The Honorable Gray Davis, Governor of California The Honorable Diana DeGette, U.S. House of Representatives, Colorado Mr. Neil Diamond Mr. Placido Domingo Miss Donna Douglas President and Mrs. Gerald R. Ford Mr. David Foster Mrs. Joseph Franzgrote Mrs. Sally Frerichs Mr. Kenny G Mr. David Geffen Mr. Merv Griffin Mrs. Warren Hanks Mr. Bob Hope Ms. Whitney Houston Mrs. Walter Imhoff Mrs. Olé T. Jensen Mr. and Mrs. John H. Johnson Mr. Quincy Jones

Mrs. Michael Jultak Dr. Henry A. Kissinger Mrs. Robert Knisely Ms. Sherry Lansing Mr. Jay Leno Mrs. Suzy Love Mr. Paul Marciano Miss Dina Merrill Mr. Myron M. Miller Mr. Roger Moore Evelyn and Mo Ostin The Honorable and Mrs. Bill Owens, Governor and First Lady of Colorado Sir Sidney Poitier Mrs. Calvin Pope President and Mrs. Ronald Reagan Mr. Lionel Richie Mrs. Sheldon Roger Mr. Kenny Rogers Miss Diana Ross Mr. George Schlatter Ms. Maria Shriver and Mr. Arnold Schwarzenegger Alan and Sandra Silvestri Mr. Steven Spielberg and Ms. Kate Capshaw Mrs. Robert J. Stewart Mrs. Robert Tucker Mrs. Thomas N. Tucker Miss Joan van Ark Mrs. Peter Weingarten The Honorable Wellington E. Webb, Mayor, City of Denver Mrs. Luanne Wells Ms. Barbera Thornhill and Mr. Gary L. Wilson Mr. Henry Winkler Mr. Stevie Wonder

FOUNDATION: Christine Lerner, Executive Director Sue Palandri, Program Director

NEWSNOTES is published twice a year by the Children’s Diabetes Foundation at Denver. We welcome your comments.

If you would like to submit an article or a letter to NEWSNOTES send information to: Children’s Diabetes Foundation at Denver 777 Grant Street, Suite 302 Denver, CO 80203 Hilary Sheldon Christine Lerner Editors Cindy Barton Graphic Designer Dorothy Harrington Associate Editor Know the symptoms of Childhood Diabetes: • Loss of weight • Extreme thirst • Excessive irritability • Frequent urination

A child reaching for the brass ring on a carousel is symbolic of the most important goal of the Children’s Diabetes Foundation — a cure. Your contribution on behalf of a loved one will make a difference. It will support treatment programs to assist children with diabetes in leading healthier lives; and it will fund research to help CDF “catch the brass ring” by finding a cure.

Mark an anniversary, birthday, special occasion; express appreciation or make a memorial tribute in honor of someone special with a contribution — for any amount — to the Children’s Diabetes Foundation at Denver. We now accept gifts on-line.

Donations are tax deductible.

Tax ID #84-0745008

The Brass Ring Fund

Remember a loved one –– Help CDF “Catch the Brass Ring” Enclosed is my Contribution of $ ___________________ In memory of ______________________________________ Or in honor of _____________________________________ Occasion _________________________________________ Please send acknowledgements to: (Amount of gift will not be mentioned)

Name ____________________________________________ Address __________________________________________ City __________________ State ________ Zip ___________ From Name ____________________________________________ Address __________________________________________ City __________________ State ________ Zip ___________

Children’s Diabetes Foundation at Denver Printed on Recycled Paper

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777 Grant Street, Suite 302, Denver, CO 80203 303-863-1200, 800-695-2873, www.ChildrensDiabetesFdn.org

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Carousel of Hope Ball

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Rosanne Barr and Dyan Cannon Jennifer and James Belushi Cheryl Tiegs Tom and Jillie Selleck George Hamilton and Alana Stewart Jeri Ryan Mavis & Jay Leno Geena Davis

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CAROUSEL OF HOPE 2002 MEMORIES

Nonprofit Org. U.S. POSTAGE

PAID Denver, CO Permit No. 1752 Children’s Diabetes Foundation at Denver, CO 777 Grant Street, Suite 302 Denver, CO 80203

Address Service Requested