Health & Wellness Journal #80

January 2019 | 1

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January 2019

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Inspire, Inform & Educate

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80th Edition

What you should know about Type 2 Diabetes & Heart Health

07

INSIDE

04 5 dermatologist tips for winter skincare

02

A history of cancer breakthroughs 65 years in the making

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06 A New Year, A New You

2  |  January 2019 HEALTH

A history of cancer

breakthroughs 65 years in the making By d-mars.com News Provider

W

hen the Cancer Research Institute (CRI) was founded in 1953, little was known about cancer and even less about the immune system. CRI was the first - and for many decades the only - research funding organization that believed that we could one day harness the immune system as a powerful weapon against cancer. Since then, the field of cancer immunology has blossomed and immunotherapy has revolutionized how cancer is treated, thanks in part to work funded by CRI. This year marks CRI's 65th anniversary. As part of the celebration, the nonprofit dedicated to cancer immunotherapy research released a list of 30 of the most important CRI-funded scientific breakthroughs. Each milestone can be traced directly back to CRI, which has supported more than 3,200 scientists and doctors at top institutions around the world.

Though distinct, each of these breakthroughs provided crucial pieces to the complex puzzle that CRI has long sought to solve: how the immune system can be used to save the lives of those with cancer.

Foundational discoveries Many CRI-funded foundational discoveries helped establish immunotherapy as a viable treatment approach for cancer. One particularly important discovery occurred in 1976, when a team led by Lloyd J. Old, M.D., CRI's founding scientific and medical director, revealed the existence of spontaneously occurring anti-tumor immune responses in cancer patients.

Many of today's advancements in cancer treatment are a direct of result of these foundational breakthroughs, made possible in part by the $384 million in donor support that CRI has invested in scientists over the last six decades.

Checkpoint immunotherapy Checkpoint inhibitors that target the PD-1/PD-L-1 pathway have been approved for eleven major cancer types in the United States and around the world, thanks in part to early work funded by CRI. While working in the Emory University lab of Rafi Ahmed, Ph.D., CRI-funded

fellows E. John Wherry, Ph.D., and David Masopust, Ph.D., laid the groundwork for these therapies by showing that targeting this pathway could restore the activity of "exhausted" T cells.

These treatments, however, weren't the first checkpoint immunotherapies approved by the FDA. The first, which targets CTLA-4, was approved in 2011 after a breakthrough in a phase III clinical trial with advanced melanoma patients. CRI-funded postdoctoral fellow Dr. Frank Borriello was part of Dr. Arlene Sharpe's team at Harvard Medical School that was one of the first to help clarify the role of CTLA4 in immune responses, while James P. Allison, Ph.D., 2018 Nobel Prize recipient, current director of CRI's Scientific Advisory Council, and chair of the Department of Immunology and the executive director of the Immunotherapy Platform at the University of Texas MD Anderson Cancer Center, is regarded as a pioneer and one of the driving forces behind the clinical development of anti-CTLA-4 immunotherapy.

Expanding immunotherapy's applications Beyond checkpoint inhibitors, immunotherapies like vaccines can educate patients' immune systems about what cancer "looks like," while others incorporate patients' immune cells directly. These cell-based immunotherapies continue to show great promise and are improving survival for many patients, including children, living with cancer.

In 2002, Dr. Cassian Yee, a CRI-funded clinical grantee at the Fred Hutchinson Cancer Research Center in Seattle (now at MD Anderson Cancer Center), helped lead groundbreaking work that was among the first to show that cancer patients' immune cells could be removed, enhanced in the lab, and then used to help fight their tumors. This work launched the development of many adoptive T cell immunotherapy approaches - including chimeric antigen receptor (CAR) T cell therapy, an approach recently approved by the FDA for the treatment of some types of leukemia and lymphoma.

against cancer. In fact, the first use of immunotherapy in the 1890s - by CRI's "grandfather" Dr. William B. Coley - involved infecting cancer patients with bacteria to help stimulate their bodies to attack the cancer.

Since then, we've learned much more about the roles these microorganisms play in the context of cancer immunotherapy. In 2015, CRI postdoctoral fellow Dr. Leticia Corrales, while working in the lab of the University of Chicago's Dr. Thomas F. Gajewski - a member of CRI's Scientific Advisory Council - discovered that mice with "good" bacteria were better protected against tumor development and responded much better to checkpoint immunotherapy. Subsequent work by Dr. Gajewski showed that this same connection exists in human cancer patients too, spurring a number of bacteria-based prognostic and therapeutic approaches being evaluated right now.

Looking to the future Over the past 65 years, CRI has focused on cancer research with one goal in mind: to unleash the immune system's power to cure all cancers.

"Many people living with cancer today have been able to live longer, healthier lives thanks to the power of immunotherapy and we're now seeing decades of research come to fruition," said Dr. Jill O'Donnell-Tormey, chief executive officer and director of scientific affairs at the Cancer Research Institute. "We're thrilled to have been a major part of the progress made to date, but more research needs to be done and that's why those of us at the Cancer Research Institute will continue to fund the best, most promising scientists in cancer immunotherapy research until all cancer patients benefit from these treatments."

For more information on CRI's impact on some of the most groundbreaking advances in cancer immunotherapy research, visit cancerresearch.org/breakthroughs.

(BPT)

Bacteria and viruses People often associate bacteria and viruses with the infections that can arise from these organisms. However, because of their ability to stimulate the immune system, bacteria and viruses can also promote immune responses

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January 2019  |  3

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4 | January 2019 HEALTH

dermatologist tips for winter skincare hydrated and protected. Take a short, lukewarm shower instead to avoid irritating the skin. Find that warm comfort by cozying up in a blanket afterward instead.

By d-mars.com News Provider

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he chill, the dryness, the itch: As temperatures drop, winter can wreak havoc on your skin.

Fortunately, you can fight winter's wrath by taking a few smart, proactive steps.

Winter skin woes are common, with 83 percent of Americans saying their skin feels differently during the winter than it does the rest of the year, according to a recent survey conducted online among 2,000 U.S. adults

by Harris Poll on behalf of CeraVe. More specifically, 77 percent say their skin feels dry in winter and 41 percent even describe it as itchy.

"Winter weather can affect all skin types," says boardcertified dermatologist Dr. Shari Marchbein. "Even though people are aware that their skin is dry, they often unknowingly make mistakes that can cause their skin to feel worse. Being mindful of how you're treating your skin and adapting your skincare routine are two essential ways to help ease the skin discomforts that often come with the season."

To help fight dry and itchy skin brought on by winter, Dr. Marchbein suggests five simple skincare tips:

1. Stay warm, not hot Everyone loves a long, hot shower in the winter. In fact, the survey found 50 percent of people take more hot showers during the winter. Unfortunately, hot water strips the skin of natural moisture that keeps it healthy,

2. Fix the winter itch That winter itch is most commonly caused by severely dry skin, so be sure to moisturize daily with products that contain ceramides to maintain hydration and fight dryness. Ceramides are naturally found in skin but can be regularly disrupted by factors like the environment and daily activities, leading to dry skin. Keep a tub of a ceramide-rich cream in your bathroom to slather on while your skin is still wet after showering to really seal in moisture and help restore the skin's protective barrier.

For added moisture and protection, use an ointment like CeraVe Healing Ointment, which contains ceramides and helps to heal dry, chapped skin, and immediately slip on socks, gloves and comfortable clothes to help it soak in.

3. Dress smart When you're heading outside, be sure to bundle up!

Always wear gear that protects your skin from the elements, like hats, scarves and gloves. Additionally, while winter makes us more inclined to bundle up in cozy sweaters, avoid any materials that may irritate your skin.

If you feel itchy under your favorite wool sweater, wear a breathable shirt underneath or consider swapping it for a different material, like fleece or cashmere.

4. Maximize moisture The colder winter air pulls moisture from the skin leaving it dry, itchy and lackluster, and heading indoors isn't helping. The rising thermostat in your house causes dry air that sucks hydration from your skin. Use a humidifier to add moisture back into the air in main spaces, like your bedroom. You should also be sure to adapt your skincare routine for the winter just like you would your wardrobe. Swap your light creams out for richer products that will add the extra moisturization needed during the winter and be sure to use them twice daily.

5. Drink up However, adding moisture back into the air isn't the only way to hydrate yourself. You should also be moisturizing yourself from the inside out by drinking plenty of water throughout the day. Water has a wide array of health benefits and the quality of your skin is one of them - especially during the winter months when we tend to lose moisture more often. Warm tea is another great way to get hydrated while comforting yourself during the colder months.

"Winter doesn't have to mean dry, itchy and uncomfortable skin," says Marchbein. "A few proactive steps and adjustments to your daily routine can help ease some of those winter worries so you can enjoy all the fun the season has to offer."

(BPT)

Mediterranean Pizza Prep time: 15 minutes; cook time: 15 minutes; Yield: Serves 4

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ith Mediterranean Pizza, there is no need to fuss with dough because whole-wheat naan, an Indian flatbread, makes the perfect crust. Simply top with cumin and paprika-seasoned ground lamb, bake it, and then finish with a lightly dressed grape and red onion combination that perfectly complements the flavors in the meat. Pita or flatbread can take the place of naan, and lamb can be replaced by ground beef or turkey as desired.

Finally, when it's time to decorate the table, create a simple but stunning centerpiece with gorgeous black, red and green California grapes.

For more ideas, visit grapesfromcalifornia.com.

Ingredients:

1 ½ cups halved red California grapes 2 tablespoons lightly chopped Italian parsley leaves ¼ cup slivered red onion 1 tablespoon lemon juice 3 tablespoons extra-virgin olive oil (divided) plus additional for drizzling Pinch of salt Freshly ground black pepper to taste 1 garlic clove, minced ½ pound ground lamb, beef, or dark meat turkey 1 tablespoon tomato paste

½ teaspoon ground cumin ½ teaspoon ground paprika Pinch cayenne 2 whole-wheat naans (about 4.4 ounces each)

Directions:

Heat oven to 475 F. In a large bowl combine the grapes, parsley leaves, red onion, lemon juice and 1 tablespoon olive oil. Season with salt and pepper and set aside.

In a large skillet heat 1 tablespoon oil.

Add the garlic and meat, and cook until browned, 2-3 minutes. Stir in the tomato

paste, cumin, paprika and cayenne.

Place naans on parchment-lined baking sheets, brush with the remaining 1 tablespoon olive oil and spread the meat mixture on the naans. Bake until each naan is browned and lightly crisp, 8-10 minutes. Top with grape mixture and drizzle with additional olive oil if desired.

Cut in pieces and serve.

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6 | January 2019 HEALTH

By d-mars.com News Provider

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an. 1 marks the official start of the new year and is our annual reminder to set resolutions, such as eating healthier, practicing mindfulness, getting organized or finally joining a gym. It's the perfect excuse to hit the reset button to lead a healthier lifestyle.

Whether that's waking up to a glass of celery juice - the go-to drink of 2018 - or taking a spin class, the challenge in getting healthier involves finding a solution that aligns with your everyday lifestyle and personal goals. Every individual's journey is different. Resolving to lose weight on Jan. 1 is the easy part. Sticking with it requires more effort.

What if you could start a weight loss journey that was sustainable? One that helps you build the habits that will carry you through Dec. 31, 2019, and beyond?

Let's get personal Effective weight loss programs must be highly personalized. Personalization plays a critical role in weight management, serving as the connective tissue between a program and the individual. Inputting height, weight, age and gender into an app or database cannot sustain a successful weight loss experience. Tracking your progress, consistent feedback, personalized coaching and motivational communications are key. These are made possible thanks to advancements in technology; which when combined with personalization can positively impact weight loss behaviors and yield real results.

Finding the right program for you Losing weight is not one-size-fits-all, hence the importance of finding a program that is right for your body, mind and schedule. Experts advise seeking programs rooted in sustainability, personalization and ease of use. Developed in collaboration with Louisiana State University's Pennington Biomedical Research Center, a worldwide leader in weight loss science, Amway's BodyKey(TM) SmartLoss(TM) program makes it easier to embrace smarter,

healthier lifestyle choices.

Accessibility is also important. The BodyKey SmartLoss program includes a free mobile app that functions as your digital coach to help you achieve and share your success with family, friends and colleagues along your weight loss journey. The app is available for anyone to download on the iTunes Store and Google Play.

"Personalization is invaluable for any successful weight loss program," said Kerry Grann, Principal Research Scientist, Amway Research & Development. "Each person is unique and requires different specificities to lose weight. What may be beneficial to one person, may not work for another. Finding a solution based on your individual needs will help you lose weight more efficiently."

Breaking barriers

daily and replacing one meal a day with a nutrient-packed shake or bar can lead to long-term success in managing weight," Grann continued. "These habits ensure daily allowances are properly met and that you receive the nutrients your body needs to lose weight."

In addition to meal replacement shakes and bars, Amway's BodyKey SmartLoss program also offers tools, snacks and teas to help make portion control easier.

As we approach a new year, now is the time to evaluate your physical, mental and spiritual health. Managing your weight doesn't have to be a lifelong struggle. Proper weight management can be safely achieved through programs such as BodyKey SmartLoss. This program, combined with a proper education on the tools and nutrients your body benefits from, can enable you to reap rewards in no time.

With no tracking or calorie counting required, Amway's BodyKey SmartLoss program effectively drives weight loss by including scientifically proven strategies to help shift away from unhealthy habits that prevent you from losing weight. It is also persona lized to help identif y potential barriers such as mindset, sleep, stress and eating teaches new skills habits, and to overcome those barriers.

"Creating healthy habits such as weighing yourself

Marrying the use of technology and Marrying the use of technology and biological processes, the program biological processes, the program features features three key elements: three key elements: • Personalized eating plan: an easy-to-follow eating plan to educate on appropriate portion size • Personalized SmartLoss Graph: to map and track healthy weight loss • SmartTips and SmartLoss Feedback: continual and tailored recommendations to keep users motivated to lose weight (BPT)

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January 2019 | 7 HEALTH

What You Should Know About

Type 2 Diabetes Heart Health By d-mars.com News Provider

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hen you're living with type 2 diabetes, there is a lot to think about when it comes to your health.

Most people know that eating healthy, staying physically active, and following a prescribed treatment plan are important to successfully manage the disease.

What many people may not know is that it's also important to understand how diabetes impacts your heart health.

An online survey was conducted on behalf of Janssen Pharmaceuticals, Inc. by The Harris Poll in February 2018, which found that nearly all of the 508 US adults age 18+ with type 2 diabetes surveyed said it's important to stay active (98%), eat healthy (99%), and follow a treatment plan exactly as prescribed (98%) in order to successfully manage their condition.

Having type 2 diabetes increases your risk for heart disease. In fact, people living with type 2 diabetes are two to four times more likely to die from heart disease than people without diabetes.

Armed with this knowledge, Matthew (60), a former postal worker who lives in Tennessee, is diligent about managing his condition and educating his loved ones about their family history and increased risks. Matthew has a long family history of type 2 diabetes, and received his own diagnosis during a hospital stay due to symptoms of heart failure. Now on a successful treatment plan, Matthew said, "I wish I had asked my doctor about heart disease earlier! I didn't know my family history soon enough."

In order to manage his type 2 diabetes and heart health, Matthew focuses on eating healthy foods, exercising regularly, and tracking his progress. He takes INVOKANA® (canagliflozin) to lower his blood sugar, which is also approved by the US Food and Drug Administration to reduce the risk of major adverse cardiovascular (CV) events in adults with type 2 diabetes who have established CV disease. INVOKANA® is the first and only oral diabetes treatment approved with this additional CV indication.

INVOKANA® is a once-daily pill used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. INVOKANA® can reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes who have established CV disease. In most clinical trials, the majority of people taking INVOKANA® reached an A1C goal of less than 7%, which is recommended by the American Diabetes

If you have type 2 diabetes, here are a few tips for living well with the condition and managing your cardiovascular risk: Learn about heart-healthy foods. These simple food swaps can help you create healthy meals and lower your risk of developing heart disease.Take the climb. Incorporate cardiovascular exercise into your daily routine - one great option is taking the stairs! Did you know you can do an entire workout on your staircase at home? These exercises will get your heart pumping. Before any strenuous physical activity, be sure to talk to your doctor.Ask your doctor about your cardiovascular risk.

Your doctor can help you understand if you are at risk for a cardiovascular event, and what you can do to lower your risk while managing type 2 diabetes.Visit INVOKANA.com to find more heart-healthy recipes and cardiovascular exercise ideas, as well as information on reducing your risk for major adverse cardiovascular events, important components in a type 2 diabetes management plan.

WHAT IS INVOKANA®?

Association. INVOKANA® is not for weight loss, but may help people lose weight-on average 2-3 percent.

INVOKANA® was also shown in clinical trials to reduce systolic blood pressure (on average 3-5 mmHg), though it is not indicated as a blood pressure medication. Results may vary by dose and when used alone or with certain other diabetes medications. INVOKANA® may increase the risk of lower-limb amputations. The most common side effects of INVOKANA® include genital yeast infections, urinary tract infection, and changes in urination. These specific adverse events were generally mild-to-moderate in intensity and infrequently led to discontinuation in clinical studies.

INVOKANA® is a prescription medicine used: along with diet and exercise to lower blood sugar (glucose) in adults with type 2 diabetesto reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes who have known cardiovascular disease. INVOKANA® is not for people with type 1 diabetes or with diabetic ketoacidosis (increased ketones in blood or urine). It is not known if INVOKANA® is safe and effective in children under 18 years of age.

IMPORTANT SAFETY INFORMATION (BPT) The content above including text, graphics, and images (“Content”), is educational only and not intended to be a substitute for medical advice, diagnosis or treatment. Reliance on any information provided here is solely at your own risk.

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8 | January 2019

Health care you can count on.

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