SYNTHETIC PATHWAY OF HAEMOGLOBIN ACETATE Kreb’s Cycle SUCCINATE CoA Mg++ ATP SUCCINYL CoA ALA-S : Synthetase ALA-DH : Dehydratase PD : Deaminase US : Synthetase UD : Decarboxylase UO : Oxidase F-CH : Ferrochelatase HS : Haemoglobin Synthetase GSH : Reduced Glutathione
PORPHOBILINOGEN PD US
PD US
+
GLYCINE+PUIDOXAL PO4
ALA-DH GSH
ALA-S
AMINOLAEVULINIC ACID (ALA) UROPORPHYRINOGEN I
UROPORRPHYRINOGEN III UD
UD
COPROPORPHYRINOGEN
COPROPORPHYRINOGEN III UO
PROTOPORPHYRIN IX + Fe++ + GLOBIN
F-CH HS
HAEMOGLOBIN
GSH