بسم ا الرحمن الرحيم
PLATELETS, MEGAKARYOCYTES AND HISTIOCYTE MORPHOLOGY Dr. Akram Al-Hilali 2011
MEGAKARYOCYTES
Large cells found only in the bone marrow after birth.
Platelets are detached from cytoplasm edge of the megakaryocytes (budding)
The do not take any of the DNA with them.
Normal megakaryocyte
Normal megakarocyte
PLATELET SIZE AND GRANULATION
Normal size platelets
Giant platelets with normal granulation
May-Hegglin anomaly (with neutrophil abnormality of Döhle bodies))
Thrombocythemia and other myeloproliferative neoplasms
Giant platelets with absent granulation (Gray platelets)
Giant platelet-May Hegglin
May-Hegglin- Neutrophil with Dohle body
Giant platelets-May-Hegglin
May Hegglin Anomaly
Giant platelets
Thrombocythemia
Gray Platelets
Gray Platelets
Gray Platelets
Gray Platelets
Gray platelets
Platelet satellitism
HISTIOCYTES
Normal cell in tissue
In marrow and spleen one may see some phagocytosis of debris and blood cells (hemophagocytosis).
Hemophagocytosis increases in some inflammatory conditions.
It is extreme in hemophagocytic syndrome
Hemophagocytosis