36
The
th Annual Meeting of March 21-22, 2015 The Endocrine Society and The Diabetes Association of the R.O.C. (Taiwan)
The Endocrinology Society Award: The Lilly Award of Japan Diabetes Society (May 1995) “Molecular Biology of the ATP-sensitive Potassium Channels” Grant Award of Japan Medical Association (Nov. 1995) “Clarification of Action Mechanism of the Anti-diabetic Agent Sulfonylureas” 50th Erwin von Berz Prize (Oct. 2013) Aglaia Award of Japan Society of Metabolism and Clinical Nutrition (Jan. 2014) Editor: Endocrinology, Editorial Board Member (Jan. 2013-present) Journal of Diabetes Investigation, Associate Editor (Jul. 2009-present) Diabetology International, Editorial Board Member (Nov. 2010-present） Diabetes and Metabolism Journal, International Editorial Board Member (Apr. 2011-present) Journal of Japan Diabetes Society, Editorial Board Member (May 2001-May 2005; May 2007-present) Research Interest: I have an interest in the molecular mechanism of insulin secretion and the pathophysiology of diabetes. We previously determined structure of ATP-sensitive K+ channel in pancreatic β-cells which is the target of the major anti-diabetes drug sulfonylureas, and identified mutations of the channel in patients with familial persistent hyperinsulinemic hypoglycemia of infancy and neonatal diabetes. We also have been devoted to the research on incretin, which is the current, important target for the treatment of diabetes. We recently are trying not only to develop the probe which enables β-cell imaging in vivo, but also to induce pancreatic β-cells from iPS cells. Publications: 215 original articles and 17 reviews Representative 10 publications: 1. Inagaki, N., Seino, Y., Takeda, J., Yano, H., Yamada, Y., Bell, G. I., Eddy, R. L., Fukushima, Y., Byers, M. G., Shows, T. B. and Imura, H. Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene. Mol. Endocrinol. 3: 1014-1021, 1989. 2. Inagaki, N., Maekawa, T., Sudo, T., Ishii, S., Seino, Y. and Imura, H. c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements. Proc. Natl. Acad. Sci. USA. 89: 1045-1049, 1992. 3. Inagaki, N., Yoshida, H., Mizuta, M., Mizuno, N., Fujii, Y., Gonoi, T., Miyazaki, J. and Seino, S. Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. Proc. Natl. Acad. Sci. USA. 91: 2679-2683, 1994. 4. Inagaki, N., Tsuura, Y., Namba, N., Masuda, K., Gonoi, T., Horie, M., Seino, Y., Mizuta, M., and Seino, S. Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. J. Biol. Chem. 270, 5691-5694, 1995. 5. Inagaki, N., Gonoi, T., Clement IV, J. P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., and Bryan, J. Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea
12
