Abstract
OD-01
THE ROLES OF ADIPOSITY ON INSULIN RESISTANCE, GLUCOSE EFFECTIVENESS, FIRST AND SECOND PHASE IN AGED SUBJECTS 1
DEE PEI, 2JIUNN-DIANN LIN, 3YEN-LIN CHEN, 2CHUNG-ZE WU, 1TE-LIN HSIA
1
Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, R.O.C.; 2Division of Endocrinology, Department of Internal Medicine, Shuang-Ho Hospital, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, R.O.C.; 3Department of Pathology, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, R.O.C.
Aims: The aim of study is to evaluate the relative influence of body mass index (BMI) on insulin UHVLVWDQFH ,5 WKH ¿UVW )3,6 DQG VHFRQG SKDVH LQVXOLQ VHFUHWLRQ 63,6 DQG JOXFRVH HIIHFWLYHQHVV *( DW D QRUPDO ¿[HG SODVPD JOXFRVH OHYHO LQ ROG VXEMHFWV Methods: In total, we enrolled 265 individuals with the same fasting plasma glucose level 5.56 mmol/l and same age 60 years old. In this way, the effects of both confounders could be adjusted. Their body mass index ranged (BMI) between 20.0-34.2 kg/m2. IR, FPIS, SPIS and GE were estimated by the equations we built previously. Since the units of the correlation lines are different, the absolute units of these four factors were transformed to relative units, the percentage. Thus, they can be compared. Results: 6LJQL¿FDQW FRUUHODWLRQV ZHUH REVHUYHG EHWZHHQ %0, DQG )3,6 63,6 ,5 DQG *( LQ ERWK JHQGHUV which were higher those reported previously. For men, SPIS is most profoundly affected by the BMI, followed by IR, FPIS and GE. For women, the order is a slightly different from that of the men, the RUGHU LV ,5 63,6 )3,6 DQG *( 7KHUH LV D VLJQL¿FDQW GLIIHUHQFH EHWZHHQ DOO WKHVH VORSHV H[FHSW IRU the slopes between FPIS and SPIS in women (p = 0.534) and between IR and FPIS in men (p = 0.258). Conclusions: The contribution of the obesity to these factors except GE were higher than that those reported previously. The BMI has the most profound effect on insulin secretion in men and on IR in women in this old cohort.
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