O1-5 EXERCISE ON INSULIN ACTION, INFLAMMATORY CYTOKINE, AND SERUM TARTRATE-RESISTANT ACID PHOSPHATASE 5A IN OBESE TAIWANESE MALE ADOLESCENTS 1 KUANG-CHUNG SHIH, 2TSU-YI CHAO, 3YU-CHING CHOU, 4CHING-FAI KWOK, 5 LOW-TONE HO 1 Division of Endocrinology and Metabolism, Tri-Service General Hospital, 2Division of Hematology/Oncology; 3School of Public Health, National Defense Medical Center; 4 Division of Endocrinology and Metabolism, Taipei-Veteran General Hospital; 5 Departments of Medical Research and Education The benefits of the exercise in glucose metabolism, inflammatory markers, and serum tartrate-resistant acid phosphatase 5a (TRACP 5a) protein levels in Chinese male adolescents has not been extensively studied. In this study, we examine the effects of a 12-week exercise program on weight, adiposity, insulin sensitivity (IS), and markers of inflammation, including the novel macrophage marker, TRACP 5a levels in obese Chinese male adolescents. A total of 106 male adolescents were recruited from Army Academy, Taiwan and classified as lean (mean+SEM: age, 15.8+0.1 years, body mass index, 20.9+0.2 kg/m2) or obese (mean+SEM: age, 15.9+0.1 years, body mass index, 27.7+0.2 kg/m2). The obese group participated in 12-week exercise intervention, the lean group did not. Body composition, IS, and inflammatory markers were measured in both groups and in the obese group after completion of the exercise program. Body weight (P<.001), body mass index (P<.001), waist circumference (P<.001), body fat (P<.001), homeostasis model assessment for insulin resistance (P<.01), fasting plasma glucose (P<.001), fasting serum insulin (P<.01), 2-hour post-challenge plasma glucose concentration (P<.001), interleukin-6 (IL-6) (P<.001), C-reactive protein (CRP) (P<.001) and serum TRACP 5a (P<.001) were significantly higher in the obese group than the lean group. Significant reductions occurred in all anthropometric (P<.001), metabolic (P<.01) and inflammatory indicators (P<.01), except serum TRACP 5a (P>.05), after completion of the exercise program. Obese male adolescents display insulin resistance and elevated inflammation markers including serum TRACP 5a. While obese subjects remained obese, exercise training resulted in significant improvement in IS and attenuation of IL-6 and CRP. TRACP 5a protein was unaffected by exercise training, consistent with our hypothesis that it is a novel marker of macrophage number, associated with increased adipose tissue in obesity. － 128 －

98年度年會論文摘要集