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AN INTEGRATED & FUNCTIONAL APPROACH
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HOW PROTEINS WORK Mike Williamson
H
OW PROTEINS WORK is an up-to-date and authoritative account of protein function in living systems, explained within the governing parameters of physics, chemistry, and evolution. This text will enable advanced undergraduate students in biochemistry and biophysics to understand the relationships among protein function, structure, and dynamics. It will also serve as a valuable resource for graduate students and researchers looking for a reference on the fundamentals underlying protein function.
E2 forms core E3
E1 How Proteins Work | A 1010 Williamson | 978-0-8153-4446-9
By providing an integrated view of proteins at both a cellular and systemic level, this textbook shows how evolution drives proteins to adopt domain structures that combine to achieve biological outcomes. The association of proteins into dimers, molecular machines, and multi-enzymatic complexes enables them to achieve catalytic and functional efficiency.
Contents 2. Protein Domains
Mike Williamson did his
4. Protein Interactions in vivo 5. How Enzymes Work
O
6. Protein Flexibility and Dynamics
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PhD and subsequent research N H
7. How Proteins Make Things Move 8. How Proteins Transmit Signals
at the University of Cambridge before moving to the lab of Nobel Laureate Kurt Wüthrich in Switzerland. There he
O N H
C
worked on the first NMR structure of a globular protein. He is a professor of Biochemistry at the University of
11. Techniques for Studying Proteins A sample chapter is available at www.garlandscience.com/hpw.
The arrangement of the E1, E2, and E3 subunits within the E. coli PDH complex.
The Author
3. Oligomers
10. Multi-Enzyme Complexes
design10.10 by www.blink.biz © www.garlandscience.com FIGURE
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1. Protein Structure and Evolution
9. Protein Complexes: Molecular Machines
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Sheffield. N How FIGURE Proteins 1.39 Work | A 139 Williamson | 978-0-8153-4446-9 An α helix has a
design by www.blink.biz © www.garlandscience.com macroscopic dipole
moment.
July 2011 • 464 pages • 537 illustrations • Paper: 978-0-8153-4446-9 • £46.00
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Key Features:
allosteric effector
• An up-to-date, integrated and coherent account of the relationship among protein function, structure and dynamics. • In-text boxes provide more details on select topics, brief biographies of prominent scientists, and pedagogical analogies for further elucidation of concepts. • End-of-chapter summaries reinforce main concepts. • Numerical and thought problems for each chapter enable comprehension and calculation.
How Proteins Work | A 321 FIGURE 3.21 Williamson | 978-0-8153-4446-9
An allosteric mechanism in a two-domain enzyme.
© www.garlandscience.com design by www.blink.biz
• Further reading, recommended websites, and references are listed for every chapter. • A glossary defines words that appear in bold throughout the main text.
ONLINE RESOURCES: Online resources for instructors and students can be found at www.garlandscience.com/hpw
Instructor Resources: • PowerPoint® slides and JPEGs of the full-color art are available to adopting instructors on the Instructor Resources site. • Solutions to all problems • Over 25 movies—featured on both the Instructor and Student Resources sites.
Student Resources: • Hints to selected problems, as well as solutions to the odd problems, are provided on the Student Resources site. • Online glossary • Flashcards • Over 25 movies
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Introduction to Protein Structure Second Edition
Structure in Protein Chemistry Second Edition
978-0-8153-2305-1
978-0-8153-3867-3
NMR for Physical and Biological Scientists 978-0-8153-4103-1
Molecular Biology of the Cell Fifth Edition
Instant Notes in Biochemistry Fourth Edition
978-0-8153-4105-5
978-0-415-60845-9
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