Janeway's Immunobiology

CASE STUDIES IN IMMUNOLOGY: A CLINICAL COMPANION

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SIXTH EDITION Raif Geha, Harvard Medical School Luigi D. Notarangelo, Harvard Medical School

November 2011 400 pages • 200 illustrations Paperback • 978-0-8153-4441-4 • £35.00

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Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway’s Immunobiology, Eighth Edition. A marginal icon in Janeway’s Immunobiology provides the reader with a link to the relevant Case Study, where the science is applied in a clinical setting.

The book includes a total of 53 cases. The Sixth Edition is extensively revised and updated and includes TEN NEW CASES: • DiGeorge Syndrome • Hemophagocytic Lymphohistiocytosis • Chediak-Higashi Syndrome • Hyper IgE Syndrome • Ataxia Telangiectasia

• Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome • Severe Congenital Neutropenia • Recurrent Herpes Simplex Encephalitis • Systemic Onset Juvenile Idiopathic Arthritis • Crohn’s Disease

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TITLE Janeway’s Immunobiology, eighth edition

QTY

TITLE

ISBN

£48.00

TITLE Case Studies in Immunology, 6th edition

QTY

FIRST NAME

ISBN

£35.00

SURNAME DEPARTMENT INSTITUTION

978-0-8153-4441-4

TITLE Viruses

QTY

ISBN

£41.00

978-0-8153-4150-5

TITLE BIOS Instant Notes in Immunology

QTY

ISBN

£20.00

978-0-415-60753-7 TOTAL £

STREET CITY POSTCODE COUNTRY EMAIL TELEPHONE

MUCOSAL IMMUNOLOGY

978-0-8153-4243-4

GSIMM81101 ISBN: 978-0-418-25835-4

ase Studies in Immunology, Sixth Edition, presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. The case histories illustrate essential points about the mechanisms of immunity and describe immunological problems seen in the clinic. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. Case Studies in Immunology highlights major common disorders of immunity, including hypersensitivity types I-IV, immune deficiencies, and autoimmune disorders. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the specific disorders. An end-of-case summary, questions, and discussion points conclude each case.

Society For Mucosal Immunology

978-0-8153-4443-8

lEAFLET.indd 1

978-0-415-60753-7

978-0-8153-4150-5

978-0-8153-6500-6

978-0-8153-4142-0

978-0-8153-4146-8

11/05/2011 10:18:52

EIGHTH EDITION

JANEWAY’S IMMUNOBIOLOGY lEAFLET.indd 2

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aneway’s Immunobiology is a textbook that introduces the immune system in all its aspects to undergraduates, and also provides a treatment of the subject that is comprehensive enough to be useful to graduate students interested in research, and to medical students focused on clinical applications. The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.

Janeway’s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout—that of the host’s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way to help deliver a complete one semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.

Discussion questions are provided at the end of Chapters 2 to 16.

These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.

Opsonized antigens entering lymph nodes from afferent lymphatics bind to the complement receptors on the surface of macrophages present in the subcapsular sinus

The low endocytic and degradative activity of subcapsular macrophages preserves the antigens trapped on their surfaces, allowing B cells to encounter them

Antigen preservation by subcapsular macrophages also allows antigen to be transported into the follicle to become localized on the surface of follicular dendritic cells

afferent lymphatic vessel subcapsular sinus (SCS) follicular dentritic cell germinal center T-cell area SCS macrophage medullary sinus efferent lymphatic vessel

10.8 Opsonized antigens are captured and preserved by subcapsular sinus macrophages.

Chapter 1: Basic Concepts in Immunology Chapter 2: Innate Immunity: The First Lines of Defense Chapter 3: The Induced Responses of Innate Immunity

• The text and figures of Chapter 7 SIGNALING THROUGH IMMUNE SYSTEM RECEPTORS have been revised to present a cohesive synthesis of SIGNALING for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book.

• Updated chapter on B-CELL IMMUNE RESPONSES (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (for example, lymph nodes) and the locations at which they encounter antigen.

• Chapter 13, FAILURES OF HOST DEFENSE MECHANISMS, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways.

Chapter 4: Antigen Recognition by B-cell and T-cell Receptors Chapter 5: The Generation of Lymphocyte Antigen Receptors Chapter 6: Antigen Presentation to T Lymphocytes

Chapter 13: Failures of Host Defense Mechanisms Chapter 14: Allergy and Allergic Diseases Chapter 15: Autoimmunity and Transplantation Chapter 16: Manipulation of the Immune Response To download a detailed table of contents and sample chapters, please visit: www.garlandscience.com/imm8

August 2011 928 pages • 547 illustrations Paperback • 978-08153-4243-4 • £48.00

“…this is an excellent overview of immunology placed in a biological context….both the style of writing and the use of figures mean that complicated concepts are put across very well indeed…” —IMMUNOLOGY NEWS

CD4

CD8 Positively selecting TCR signals initially reduce CD4 and CD8 expression (CD4lowCD8lowcells), followed by re-expression of CD4, regardless of whether the initiating signal involves MHC class I or MHC class II ligands

• The ICONS used have been updated and expanded to incorporate a new emphasis on signaling pathways.

• New REFERENCES have been added throughout the text.

“The authors of the seventh edition of Janeway’s Immunobiology have maintained Charles Janeway’s signature approach to teaching immunology—integration….one of the strongest aspects of this volume is the use of visual aides….this textbook will be an outstanding learning tool.” —THE QUARTERLY REVIEW OF BIOLOGY “This is one of the best basic immunology textbooks available. Materials are well organized and clearly presented. It is a must-have… The chapters are well ordered and the language is clear and succinct. Ample, well-designed diagrams and tables illustrate complex ideas.” —DOODY REVIEWS

CD4

CD8

The division of thymocytes into the CD4 or CD8 lineage occurs at this CD4+CD8low stage, where transient expression of ThPOK leads to CD4 commitment, or its absence leads to CD8 commitment

“Each aspect of immunology is covered in great depth and detail. In addition, a great summarizing paragraph can be found at the end of each chapter to help you obtain a general overview. Supported by simple and clear illustrations, tables and interactive materials…it contains all you need to know in immunology.” —GKT GAZETTE

RESOURCES

CD4

CD8 CD4+ single positive CD4+CD8low CD4lowCD8low CD4+CD8+ double positive (DP) CD4–CD8– double negative (DN) CD4lowCD8+ CD8+ single positive

8.31 Stages in the positive selection of α:β t cells as identified by FaCS analysis.

Schematic representation of a follicle with a germinal center

mantle zone centrocytes follicular dendritic cells

Light zone

centroblasts Dark zone

helper T cells

i7-31

Cyclic reentry of cells into the dark zone is dependent on reexpression of CXCR4 on centrocytes

CXCL13 +

CXCR5 B cells

+

CXCR4 B cells

CXCR12

• Chapter 16, MANIPULATION OF THE IMMUNE RESPONSE, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines.

• MANY NEW AND REVISED FIGURES illustrate the processes and mechanisms underlying the concepts presented in the text.

PRAISE FOR THE PREVIOUS EDITION

CD4–CD8– (DN) thymocytes give rise to the CD4+CD8+ (DP) thymocytes that express low levels of TCR and await positive selection

• EVOLUTION is now incorporated throughout the text, helping students see similar strategies used by different organisms.

Chapter 9: T Cell-Mediated Immunity Chapter 10: The Humoral Immune Response Chapter 11: Dynamics of Adaptive Immunity n10-100 Chapter 12: The Mucosal Immune System PART V: THE IMMUNE SYSTEM IN HEALTH AND DISEASE

Chapter 7: Signaling Through Immune System Receptors Chapter 8: The Development and Survival of Lymphocytes

• The section on COMPLEMENT has been reworked and reconceived—explaining the lectin pathway first—making it easier to teach by placing it into the context of innate recognition.

PART IV: THE ADAPTIVE IMMUNE RESPONSE

PART II: THE RECOGNITION OF ANTIGEN

PART III: THE DEVELOPMENT OF MATURE LYMPHOCYTE RECEPTOR REPERTOIRES

• INNATE IMMUNITY has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook.

Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (for example, TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes).

• Chapter 12, MUCOSAL IMMUNOLOGY, has been revised, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria.

TABLE OF CONTENTS PART I: AN INTRODUCTION TO IMMUNOBIOLOGY AND INNATE IMMUNITY

NEW IN THE 8TH EDITION

10.11 the structure of a germinal center.

FOR INSTRUCTORS • Animations and Videos For instructors and students we offer over 40 original immunological animations based on figures in the book and videos selected from visually compelling experiments. The animations have been revised and updated for this edition, and there are five new animations covering NALP3 Inflammasome, Isotype Switching, CD28, Crohn’s Disease, and NFAT Activation and Cyclosporin. All the animations and videos are accompanied by a voice-over narration.

• The Art of Immunobiology: The figures and tables from the book are available preloaded into PowerPoint® presentations and as JPEGs. • Lecture Outlines in PowerPoint®

FOR STUDENTS

• Animations and Videos • Online Searchable Glossary • Interactive Flashcards

THE AUTHOR

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Kenneth Murphy is the Eugene Opie First Centennial Professor of Pathology and immunology at Washington University School of Medicine in St. Louis and investigator at the Howard Hughes Medical Institute. He obtained his MD and PHD degrees from the Johns Hopkins University School of Medicine.

11/05/2011 10:18:59