Introduction to Cell Mechanics and Mechanobiology

A NEW APPROACH TO C E L L M EC H A N I C S FOR BIOLOGY AND E N G I N E E R I N G

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KEY FEATURES

► Mathematical derivations and solved examples appear throughout the book. ► Three types of boxes supplement the main text: • Advanced Material challenges readers to think critically and/or problem solve.

• Examples provide in-depth calculations and explanations.

• Nota Bene present noteworthy and interesting asides. ► Key Concepts summarized at the end of every chapter, along with annotated references, and homework problems.

Christopher R. Jacobs, Hayden Huang, Ronald Y. Kwon

Introduction to Cell Mechanics and Mechanobiology is designed for a

September 2012 350 pages • 250 illustrations Paperback • 978-0-8153-4425-4 £44.00

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one-semester-course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering, bioengineering, and mechanical engineering. It teaches a quantitative understanding of the way cells detect, modify, and respond to the physical properties within the cell environment.

Coverage includes the mechanics of single molecule polymers, polymer networks, two-dimensional membranes, whole-cell mechanics, and mechanobiology, as well as primer chapters on solid, fluid, and statistical mechanics.

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Introduction to Cell Mechanics and Mechanobiology is the first cell mechanics textbook to be geared specifically toward students with diverse backgrounds in engineering and biology.

ONLINE RESOURCES

Online resources for students and instructors can be found at www.garlandscience.com/cell-mechanics FOR QUALIFIED INSTRUCTORS: • Artwork in JPEG & PowerPoint® formats.

• Solutions to end-of-chapter problems.

FOR STUDENTS: • Selected figures and animations.

• Matlab computer simulation modules.

• Solutions to selected end-of-chapter problems.

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CONTENTS

dL elongation rate — (dt)

PART I. PRINCIPLES

+ end elongation

shrinking

− end

K

4.15 A bacterium swimming in a fluid at velocity V c4.15 moving to the left) in a fluid of density r and viscosity m with length L experiences some drag slowing it down.

Custom Publishing: http://garland.sharedbook.com Garland Science Custom Publishing enables the creation of materials from multiple sources, including Introduction to Cell Mechanics and Mechanobiology, in just a few clicks.

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Cell Mechanics as a Framework Fundamentals of Cell Biology Solid Mechanics Primer Fluid Mechanics Primer Statistical Mechanics Primer

PART II. PRACTICES 7.9 The kinetics of polymerization are different at the (+) and (-) c7.7 ends of the polymer. Polymerization/depolymeri7.9 zation kinetics tend to be faster at the (+) end and slower at the (-) end for a given subunit concentration.

6. Cell Mechanics in the Laboratory 7. Mechanics of Cellular Polymers

8. Polymer Networks and the Cytoskeleton 9. Mechanics of the Cell Membrane 10. Adhesion, Migration, and Contraction

of the Cell 11. Mechanotransduction and Intracellular Signaling A sample chapter and detailed table of contents are available at www.garlandscience.com/cell-mechanics.

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THE AUTHORS CHRISTOPHER R. JACOBS is an associate professor of Biomedical Engineering at Columbia University. He has worked to define the role of primary cilia as bone cell mechanosensors in vitro and in vivo. Most recently his research has centered on modeling the non-linear fluid-structure behavior of primary cilia and how they are affected by both mechanical and biological factors. Dr. Jacobs is an Associate Editor for the Journal of Biomechanics, Cell and Molecular Bioengineering, and the North American Editor for Computer Methods in Biomechanics and Biomedical Engineering.

HAYDEN HUANG is an assistant professor of Biomedical Engineering and directs research in the Biomechanics and Mechanotransduction Laboratory at Columbia University. As a former Whitaker Fellow, his research focuses on the influence of physical forces on cells, with some emphasis on the interaction between cells at cellular junctions. Dr. Huang has published in a variety of journals, including Circulation, Biophysical Journal, and PLoS One. RONALD Y. KWON is an acting assistant professor in the Department of Orthopaedics at the University of Washington. His broad interests are in merging experimentation, computation, and imaging for the investigation of musculoskeletal mechanobiology. His current research focuses on using zebrafish for large-scale screening and systems-level investigation of neuro-musculoskeletal disorders. A former NIH National Research Service Award Fellow, he has been recognized with a number of awards including Young Investigator Awards from the American Society of Bone and Mineral Research and the International Bone Fluid Flow Workshop.

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