The United States is active in many areas of global health, directing financial, technical and programming assistance to developing countries that will improve the health and wellbeing of millions of people through increased access to live-saving goods and services. Many positive outcomes have resulted from the assistance provided by U.S. programs, including the President’s Emergency Plan for AIDS Relief (PEPFAR) and the President’s Malaria Initiative (PMI), as well as programs to address tuberculosis (TB), maternal and child health, and reproductive health. In May 2009, the United States introduced the Global Health Initiative (GHI), the first comprehensive approach to global health that aims to build upon the successes of PEPFAR and PMI. The GHI supports the goals outlined for PEPFAR and PMI, and aims to link these efforts with other global health programs.