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W O R L D ’ S C L I N I C A L L A B O R AT O R Y N E W S L E A D E R ISSN 1068-1760
Vol. 33 No. 1 • 2-3/ 2016
DAILY CLINICAL LAB NEWS
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Gene Test Validated for Breast Cancer Therapy genetic test has been clinically validated in predicting which patients with early-stage breast cancer are unlikely to benefit from chemotherapy. Many women with hormone receptor-positive breast cancers also undergo chemotherapy in order to destroy any cancer cells that many have
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Breakthrough Technology Characterizes Immune Response ssays enabling the identification and enumeration of antigen-specific T cells are critical tools in characterizing immune responses and harnessing T cell function for treatment of numerous diseases including cancer. A novel multiplex assay has been developed that combines convention-
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al immune monitoring techniques and immune receptor repertoire sequencing to enable identification of T cells specific to large numbers of antigens simultaneously. Scientists at Adaptive Biotechnologies (South San Francisco, CA, USA; www.adaptivebiotech.com) multiplexed 30 different antigens and
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Image: Courtesy of Luke Lee / University of California Berkeley
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Liquid Biopsy Tests Offer Game-Changer In Cancer Treatment
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-reactive protein (CRP) is a biomarker in blood, which indicates the presence of inflammation, and the amount of CRP in the body gives an indication of the severity of an infection. Low levels of CRP are indicative of viral Cont’d on page 4
Early Warning Biomarker for Chronic Kidney Disease
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simple blood test for a specific protein can predict a person’s chances of developing chronic kidney disease five years before symptoms emerge, thus doing for kidney disease what cholesterol has done for cardiovascular disease. Relatively high plasma levels of the specific protein soluble urokinase-type
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he ability to simultaneously detect and identify multiple biomarkers is one of the key requirements for molecular diagnostic tests that are becoming even more important as personalized and precision medicine place increased emphasis on such capabilities. Integrated optofluidic platforms can help create such highly sensitive, multiplexed assays on a small, dedicated chip and a method for multiplex fluorescence
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he diagnosis of celiac disease requires a tissue sample from the small intestine, which can be extremely unpleasant, but a blood test has been developed which provides a rapid, painless answer. The tissue samples are taken by gastroscopy, which means a tube being inserted down the throat to the duodenum and then tissue samples must also be taken in order to obtain a definite diagnosis. This can be very
Image: A lung cancer tumor cell in situ
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On-Chip Optical Sensing Of Multiple Flu Strains
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Simplified Blood Test For Celiac Disease
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ersonalized cancer treatment requires the frequent tracing of cancer DNA in the blood, in order to determine and monitor the treatment most likely to work for the individual patient. Emerging liquid biopsy tests are now offering a noninvasive, simpler and more-effective alternative to surgical biopsies toward that end.
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plasminogen activator receptor (suPAR) have been associated with focal segmental glomerulosclerosis and poor clinical outcomes in patients with various conditions. Scientists at Rush University Medical Center (Chicago, IL, USA; www.rush.edu) and a large team of collaborators, measured plasma suPAR Cont’d on page 6
Clinical News . . . . . . . . . 4-26 IFCC News . . . . . . . . . . . . . 27 EFLM Corner . . . . . . . . . . . 30 Product News . . . . . . . 10-24 Industry News . . . . . . . . . .33 International Calendar . . . 34 PUBLISHED IN COOPERATION WITH
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