Aging Matters Issue 2 2015

No 2, 2015

US $8.00/ EU €6.00/ GB £5.00 where sold

An anti-diabetic, weight loss agent Dr Ward Dean describes Acarbose

PLUS: The almost forgotten role of the thymus Beating the flu season Pyridoxamine - a universal agent against aging The in-house magazine for International Antiaging Society Group Private Club Members

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TRH stands for thyrotropin releasing hormone, however TRH has a far wider role than ‘just’ supporting the thyroid.

According to Dr. Walter Pierpaoli, TRH is a fundamental life-giving molecule that boosts immunity, helps to reverse aging (by improving numerous lipid ratios) and through this action appears to help induce significant weight loss within Dr. Walter Pierpaoli

a few months.

TRH Abaris™ 20 Sublingual Tabs $209.99 *Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

WELCOME Dr. Dean knows all about the negative aspects of Syndrome X because he was instrumental, along with Professor Vladimir Dilman, in bringing to the attention of the world - the neuroendocrine theory of aging - on which it is based. It would seem that diabetic effects and weight gain go hand in hand, so you may find Dr. Dean’s detailed article about the starch blocking effects of acarbose of interest on a number of levels.

Furthermore, you will see that nutritionist, Karen Kaufman also highlights the benefits of the rare form of vitamin B6 and how it too helps to control weight, diabetes and ergo the deleterious aspects of aging.

I’m also delighted to have interviewed Richard Stead, the inventor of 1st Line™ to find how this bioidentical agent is helping to battle viruses. I also hope that you may find my own contribution regarding the thymus gland of some interest.

Lastly, you may notice that there are other changes to the layout of the magazine. We are now offering more information on specific products and ailments. It’s all designed to inform you better, so that your optimal health-span can be maintained for as long as possible.

INDE X WELCOME Phil says thanks for finding the time

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FOREFRONT This month’s news

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AN ANTI-DIABETIC AND WEIGHT LOSS AGENT Dr Dean describes acarbose

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THE ALMOST FORGOT TEN THYMUS GL AND What role does it play?

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BEATING VIRUSES NATUR ALLY An interview about 1st Line™

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PYRIDOX AMINE, A UNIVERSAL ANTIAGING SUPPLEMENT The benefits of the rare form of B6

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FEATURED PRODUCTS Best sellers and new items

Phil Micans, MS, PharmB Editor, Aging Matters™ Magazine

Ward Dean M.D., Medical Director

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A-Z PRODUCT LISTING AND PRICES Find everything in-stock here

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CROSS -REFERENCE LISTS Find what you need here

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TESTIMONIALS & EXPLANATIONS

TOMORROW’S TREATMENTS TODAY

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• Quality: We stock the best quality products because the right materials and formulas give you the best possible results.

• Brands: We carry original brands - i.e. the same ones used by top health professionals.

• Choice: We have the largest range of medicines, hormones and supplements. If you are looking for things that use words like bioidentical, efficacy and synergy then you’ve come to the right place.

• Pricing: Our prices are competitive and we regularly have special offers to help you save money on the things that are important to you and your family.

• Support: Our friendly and professional customer care team are on-hand to help you. We can be bothered!

• Professional: We work alongside the leaders in the field and we review the latest research to ensure that everything is up-to-date. After all, if we are informed then so are you.

• Sponsorship: All over the world you will find IAS supporting, sponsoring, exhibiting and lecturing at key venues. You can meet us in person and see what we believe in.

Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members (and therefore is not intended for the public). It focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the main focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual.

Copyright 2015: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents.

Disclaimer: All educational information is offered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. All prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice.

3

FOREFRONT THE THINGS YOU NEED TO K NOW FROM THI S MONTH’ S NE WS

Fatuous A recent re-examining of previous studies on saturated fat by academics at the University of Cambridge has concluded there is no link between eating foods such as fatty meat, cream or butter and developing heart disease. This overturns nearly half a century of mainstream dietary advice and now firmly points the finger at consuming carbs and sugar as the main culprits in the worldwide spread of diabetes and heart disease.

The researchers are calling for guidelines to be changed to reflect the growing body of evidence to support their findings.

Lead researcher Dr Rajiv Chowdhury, said: “These are interesting results that potentially stimulate new lines of scientific inquiry and encourage careful reappraisal of our current nutritional guidelines.

“Cardiovascular disease, in which the principal manifestation is coronary heart disease, remains the single leading cause of death and disability worldwide.

In 2008, more than 17 million people died from a cardiovascular cause globally.

“With so many affected by this illness, it is critical to have appropriate prevention guidelines which are informed by the best available scientific evidence.”

The team conducted a “meta-analysis” of data from 72 studies involving more than 600,000 participants from 18 countries.

4

One of the key findings was that total saturated fat, whether measured in the diet or the bloodstream, showed no association with heart disease.

Associate medical director at the British Heart Foundation Professor Jeremy Pearson, - which co-funded the study, said: “This analysis of existing data suggests there isn’t enough evidence to say that a diet rich in polyunsaturated fats but low in saturated fats reduces the risk of cardiovascular disease.

“But large scale clinical studies are needed, as these researchers recommend, before making a conclusive judgement.

“Alongside taking any necessary medication, the best way to stay heart healthy is to stop smoking, stay active, and ensure our whole diet is healthy -

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and this means considering not only the fats in our diet but also our intake of salt, sugar and fruit and vegetables.”

FOREFRONT Eight year old girl suggests a possible cure for cancer Camilla Lisanti from Manchester in the UK may have provided her research scientist parents with a viable new direction in for their search for a cure to cancer.

Over dinner one night her father Professor Micheal Lisanti asked her how she would go about curing cancer. The eight-year-old child thought for a moment and then suggested using antibiotics, “like when I have a sore throat,” to her sceptical parents.

Professor Lisanti and his wife Federica Sotgia, a husband and wife cancer

research team, tested her theory at their lab at Manchester university and were stunned when their research revealed that four common antibiotics, which can cost as little as six Pence a day compared to some of the latest drugs which can cost hundreds of Pounds, killed these stem cells in samples from breast, prostate, lung, ovarian, pancreatic,

skin and brain tumours.

The antibiotics tested stop the cancer cells from making mitochondria, which supply them with energy. Crucially, the antibiotics did not harm healthy cells.

Coffee consumption may lower risk of Alzheimer’s Drinking 3-5 cups of coffee per day may help to lower the risk of Alzheimer’s Disease by up to 20%, according to research highlighted in an Alzheimer Europe session report published by the Institute for Scientific Information on Coffee (ISIC), a not-for-profit organisation devoted to the study and disclosure of science related to coffee and health.

The report explores the compounds within coffee, which may be responsible for this protective effect, identifying caffeine and polyphenols as key candidates.

Caffeine helps prevent the formation of amyloid plaques and neurofibrulary tangles in the brain - two hallmarks of Alzheimer’s Disease. In addition to this, both caffeine

and polyphenols reduce inflammation and decrease the deterioration of brain cells especially in the hippocampus and cortex, areas of the brain involved in memory.

Dr. Iva Holmerova, vice chairperson of Alzheimer Europe, commented: “The findings presented in this report are very encouraging and help to develop our understanding of the role

nutrition can play in protecting against Alzheimer’s Disease.

Coffee is a very popular beverage enjoyed by millions of people around the world and I’m pleased to know that moderate, lifelong consumption can have a beneficial effect on the development of Alzheimer’s Disease.”

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55

Acarbose:

By Ward Dean, M.D.

An anti-diabetic and potential weight loss agent Acarbose (Glucobay®, Precose®) is a drug approved for use in (1) insulin-dependent diabetes mellitus (Type I), (2) adult-onset diabetes mellitus (AODM, or Type II), and (3) those who suffer from “impaired glucose tolerance.” As I’ve previously pointed out, virtually everyone over the age of 35 is probably functionally glucose intolerant to some degree (Fig. 1). Using even the strictest orthodox criteria, it is estimated that up to 20% of Caucasians between the ages of 65 and 75 years have Type II Diabetes-and an additional 23% have “impaired glucose tolerance” (2).

To understand how acar-

bose works, a review of a few basics of carbohydrate metabolism is in order. Starches and complex sugars are broken down in the digestive tract into simple sugars, which are then absorbed by the body (in the lower small intestine and colon). These simple sugars are used for energy, or stored (as glycogen or fat).

Enzymes are essential to break down the complex carbohydrates into sugars.

Certain groups of enzymes are critical to the final steps in the digestion of carbohydrates. One of these groups is the alpha-glucosidases.

Alpha glucosidases enhance the breakdown of maltose,

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Figure 1. Progressive loss of glucose tolerance with age. This illustrates how the rise in insulin following a glucose tolerance test progressively increases with age, and takes longer to return to baseline. Only those ten years of age and younger have “normal” (optimal) glucose tolerance –the rest of us suffer from what Dilman called “pre-diabetes” (1).

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Acarbose Sites of Action Starch Lumen Sucrose a-amylase Maltose Maltotriose Dextrins

Maltose Isomaltase Glucoamylase Glucose

Sucrase Glucose Fructose

Sites of competitive inhibition

Figure 2. Simplified representation of alpha glucosidase inhibition. The bold blocks indicate the points at which acarbose delays the production of monosaccharides and, as a consequence, their intestinal absorption (3).

isomaltose, glucoamylose and sucrose (table sugar). Acarbose acts as a potent competitive inhibitor of intestinal brush border alpha glucosidases that are essential for the breakdown of starches, dextrins, maltose, and sucrose to absorbable monosaccharides (Fig. 2). Because of its specificity for alpha glucosidases, beta glucosidases such as lactases are not affected by acarbose. Glucose is also not affected by acarbose. Consequently, glucose and lactose are absorbed normally when

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acarbose is taken.

Effects of Acarbose Acarbose delays carbohydrate digestion and absorption (Fig. 3). Consequently, it delays and flattens post-meal rises in glucose and insulin (5, 6) (Fig. 4). Fasting and post-meal triglyceride levels are decreased (7,8) (probably due to the reduced insulin response) (3), and reductions in low-density lipoproteins (LDL)

Without Acarbose

With Acarbose

Upper small intestine

Upper small intestine

Carbohydrates

Lower small intestine

Lower small intestine

Carbohydrate resorption

decreasing fasting blood glucose). Chiasson, et al (5) also believed Acarbose improved insulin sensitivity, based on their finding that patients taking acarbose experienced an upward trend in post-meal C-peptide levels. Furthermore, acarbose appears to prevent or delay the progressive deterioration in pancreatic beta cells that routinely occurs in patients with Type 2 DM (2).

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Effects of Acarbose on Glucose and Insulin after a Meal Without acarbose (baseline FPG 160 mg/dL) Single-does acarbose (baseline FPG 158 mg/dL)

Glucose Increase % above baseline

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Figure 5. Age-related rise of HbA1c, indicating loss of glucose tolerance with increasing age (10).

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FPG = fasting plasma glucose Reprinted with permission from Kado S et al. Diabetes Clin Pract. 1998;41:49-55. Copyright 1998 Elsevier. All rights reserved.

Figure 4. Effect of Acarbose vs placebo on post-prandial (after a meal) levels of glucose and insulin in diabetics treated with a sulfonylurea (6).

and increases in high-density lipoproteins (HDL) have been reported (9).

Glycosylated haemoglobin (hemoglobin A1c [HbA1c]) is a screening and diagnostic test for diabetes, as well as a biomarker of aging (indicator of biological age).

HbA1c tends to increase progressively with age in non-diabetic subjects (Fig. 5) (10). Acarbose has been demonstrated in numerous studies to significantly reduce HbA1c (3, 11, 12) (Fig. 6).

The reduction in HbA1c has a number of other beneficial

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Figure 3. Acarbose is poorly absorbed, and is excreted predominately in the feces. This illustrates how Acarbose acts non-systemically to delay carbohydrate absorption (4).

patients given Acarbose (16).

Because acarbose does not result in hypoglycemia, it can be safely used by those who suffer from reactive hypoglycemia—and will probably benefit the condition due to its insulin-modulating properties.

In 2003, results from the STOP-NIDDM trial were reported (17). The trial was an international, multicentre double blind trial involv-

effects, including decreased glycation of glomerular basement membranes, decreased advanced glycosylation end product (AGE) formation in connective tissue, decreased cataract formation, and prevention of neuropathy and retinopathy (13).

In addition, of particular significance with respect to the mechanism of aging proposed by Dilman’s neuroendocrine theory of aging, Balfour and McTavish (14) speculated that Acarbose might improve insulin sensitivity (as indicated by

B. Sulfonylurea

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Figure 6. Effect of Acarbose and placebo on HbA1c in diabetic patients treated with diet alone and diet + metformin, sulfonylurea or insulin (as indicated). The circle indicates placebo, and the square indicates the effects of acarbose (titrated to maximum 600 mg/day) added to each regimen for 12 months (5).

Other benefits of alpha glucosidase inhibitors are their ability to prevent or attenuate diabetic nephropathic lesions (15), and one study even reported an improvement in cognitive function in both animals and elderly

ing patients from Canada, Germany, Austria, Norway, Denmark, Sweden, Finland, Israel and Spain, from 1998-2001, involving nearly 1,500 patients with impaired glucose tolerance (IGT). The patients were randomized

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Mass Index), waist circumference, blood pressure, 2-hour glucose concentrations, and triglyceride levels. They concluded that Acarbose treatment was associated with a significant reduction in the incidence of cardiovascular disease and hypertension.

In 2011, scientists presented a comprehensive schematic to connect the plethora of benefits that have been attributed to this remarkable medication (Fig. 9)

Probability of any Cardiovascular Event

0.06 0.05 0.04 Placebo 0.03 0.02

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0.01 P=.04 (Log-Rank Test) P=.03 (Cox Proportional Model)

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686 675 667 658 643 638 633 627 615 611 604 519 424 332 232 682 659 635 622 608 601 596 590 577 567 558 473 376 286 203

Figure 7. Effect of Acarbose on the probability of remaining free of cardiovascular disease. (17).

STOP NIDDM: Incidence of New Cases of Hypertension in IGT Patients Cumulative Incidence (%)

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Hypertension defined as BP>140/90 mmHg

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Years After Randomization BP, blood pressure: IGT, impaired glucose tolerance; STOP NIDDM, Study to Prevent Non-Insulin Dependent Diabetes Mellitus Trial Chlasson JL, et al. JAMA 200;290:486-494.

Figure 8. Effect of Acarbose on the probability of remaining free of hypertension. (17).

to receive placebo or 100 mg Acarbose, three times daily. The scientists wanted to evaluate whether Acarbose could prevent coronary artery disease, hypertension, congestive heart failure, or peripheral vascular disease.

The results of the study were dramatic. During the slightly more than three years of the study, 19 subjects taking placebo suffered heart attacks, compared to only 2 in the group taking Acarbose (Fig. 7). Acarbose treatment also had a significant effect on the risk of developing hypertension. Of 682 patients in the Acarbose group, only 78 developed hypertension (11%) vs 115 (17%) of those (682) 8

in the placebo group (Fig. 8).

The authors added that Acarbose treatment was associated with a significant reduction in body weight, BMI (Body

Acarbose for Weight Loss Animal studies with acarbose have consistently shown that Acarbose has a body fat-lowering action. Balfour and McTavish (14) reported that Acarbose caused a dose-dependent reduction in body weight gain of genetically obese and hyperinsulinemic rats. In higher doses, acarbose even caused a dramatic loss in weight (Fig 10).

Many studies have reported a beneficial effect of alpha glucosidase inhibitors on bodyweight in humans (9, 11, 20-22), although the effect was usually reported as “moderate.” Acarbose also demonstrated the ability to retard “relapse weight gain” in overweight patients who had lost weight before beginning treatment with Acarbose (23, 24).

In view of the salutary effect that Acarbose has on blood sugar, insulin, lipids and HbA1c, I was at first surprised at the modest weight loss reported by participants in the studies (especially compared to the significant benefit I routinely observe in my patients). However, upon reflection, the modest effects of Acarbose as a weight loss agent in the above studies can be understood. As noted, weight loss was a usual finding in the animal studies.

Most animal studies were done on normal (non-diabetic) or obese animals.

However, the human studies were quite different, as the overwhelming majority of subjects were diabetic (or had impaired glucose tolerance)— and were often simultaneously treated with sulfonylureas and/or insulin. Diabetics characteristically gain weight, due to insulin resistance and hyperinsulinemia. Sulfonylurea drugs or insulin are notorious for causing additional weight gain (Metformin, which usually results in loss of body fat, was not commonly used in most of the earlier studies cited above).

More recent studies, however, have shown much more positive results—since the drugs used were Acarbose alone, or Acarbose

Macrovascular Events

Atherogenesis

TGL, LDL/HDL

Endothelial Dysfunction

Figure 9. Proposed cardiovascular benefits of Acarbose. (18)

Inflammatory markers

Acarbose

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T2DM

Key: BP= blood pressure; HDL = high-density liopprotein; IGT = impaired glucose tolerance; LDL = low-density lipoprotein; PPBG = postprandial blood glucose; T2DM = type 2 diabetes mellitus; TGL = triglycerides

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Figure 10. Effect of acarbose on body weight gain and food intake of genetically obese “Zucker” rats. (19).

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Figure 11. Incidence of adverse effects with Acarbose (usually 300-600 mg/day) in 962 diabetic patients for periods up to two years (27). The high incidence of side effects was due to the excessive doses (up to 600 mg/day) of Acarbose.

combined with Metformin.

In a large-scale observational study of some 15,000 patients in China, Taiwan, the Middle-East, Morocco, Poland, Indonesia, Pakistan and the Philippines, with a follow-up of three years, a notable weight decrease was seen in all treatment groups (Acarbose alone, or Acarbose combined with Metformin and sulfonylureas or insulin) (25). In an even more recent study in China, 784 newly-diagnosed diabetics were placed on Acarbose or Metformin.

After 48 weeks, the scientists determined that Acarbose had similar efficacy to Metformin (in terms of glycemic control), but that more bodyweight was lost in the Acarbose-treated group (26).

Adverse effects and safety Acarbose is a very safe drug; only about 1-2% is absorbed systemically. The most frequent side effects are all due to the unabsorbed carbohydrates, which ferment in the colon and can cause sometimes uncomfortable or embarrassing increased gas production, abdominal cramps, bloating and even diarrhea (Fig. 11). These effects can be minimized by taking the lowest effective dose—i.e., below that which causes the gastrointestinal distress.

Continued use usually results in a reduction or resolution of these symptoms. As some tolerance seems to develop, dosages can be increased to the maximum recommended

dosage of 300 mg daily.

In 1988, Clissold and Edwards (6) reported that “from the large clinical studies reported to date, acarbose— even after treatment for up to 5 years-does not produce any clinically significant adverse effects on biochemical and hematological parameters” (emphasis added). In another large placebo controlled study, doses of acarbose as large as 200 mg three times daily had no toxic effect according to the results of hematologic and biochemical profiles, including liver function tests (5) (although these high doses did cause a higher incidence of abdominal side effects, as indicated in Fig. 11).

Acarbose is contraindicated in people with inflammatory bowel disease, colonic ulceration or partial intestinal obstruction, predisposition to intestinal obstruction, chronic intestinal disease associated with marked disorders of absorption or digestion, conditions which might be exacerbated by increased intestinal gas formation (like hernias), or impaired hepatic function.

carbohydrate components of a meal.

Since Acarbose is not available as a powder, and is actually pleasant-tasting, I suggest that it be chewed with food at the beginning of meal or when consuming a starchy snack. I recommend that Acarbose be started at as little as 25 mg daily, to minimize side effects, and gradually advance the dosage and frequency as tolerance develops, up to a maximum dosage of 100 mg three times daily, chewed with meals. Of course, if one is on a strict high protein/”Atkins Diet,” Acarbose is not necessary.

Dosage Acarbose works best when it is combined with food.

When taken as a tablet, it is only ¼ as effective as when consumed in powdered form (Fig. 12). O’dea and Turton (28) recommended that Acarbose be marketed as a powder rather than a tablet, so it could be mixed into the

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Plasma Glucose (mmol/l)

References

1. Dilman V, and Dean W. The Neuroendocrine Theory of Aging and Degenerative Diseases, Center for Bio-Gerontology, Pensacola, Florida, 1992.

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2. Rabasa-Lhoret, R, and Chiasson, J-L. Potential of alpha-glucosidase inhibitors in elderly patients with diabetes mellitus and impaired glucose tolerance. Drugs and Aging, 1998, 13(2): 131-143.

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3. Clissold SP, and Edwards C. Acarbose—A preliminary review of its pharmacodynamic properties, and therapeutic potential. Drugs, 1988:35; 214-243,.

4 3

4. Standl, E, and Schnell, O. Alpha-Glucosidase Inhibitors 2012—cardiovascular considerations and trial evaluation.

Diabetes & Vascular Disease Research, 2012:9(3);163-169.

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5. Chiasson, J.L., Josse, R.G., Hunt, J.A., Palmason, C., Rodger, N.W., et al. The effectiveness of Acarbose in the treatment of patients with NIDDM. A multi-centre controlled clinical trial. Ann Intern Med, 1994, 121: 928-935.

Plasma Insulin (mU/l)

60 50 40

6. Kado S, Murakami T, Aoki A, et al.

Effect of Acarbose on postprandial lipid metabolism in type 2 diabetes mellitus.

Diabetes Res Clin Pract. 1998;41:49-55.

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7. Lardinois CK, Greenfield MS, Schwartz HC, et al. Acarbose treatment of non-insulin dependent diabetes mellitus. Arch Intern Med, 1984, 144: 345-7.

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GBR + 50mg Acarbose tablet GBR + 50mg Acarbose powder Figure 12. Comparison of Acarbose powder and tablets on post-meal glucose and insulin concentrations. After ingestion of 75 gram starch (ground brown rice—GBR) with 50 mg Acarbose--either mixed in the meal as a powder (- - -) or eaten with the first mouthful as a tablet ( ----- ), clearly shows that Acarbose powder mixed with the food is much more effective than when consumed as a tablet (28).

Conclusion I believe that acarbose, like metformin; will become increasingly recognized for its potential caloric-restriction-mimicking/anti-aging, cardio-protective and anti-obesity effects. In fact, Acarbose and Metformin can be taken together, potentiating each other’s beneficial effects. Curiously, despite the well-documented safety and efficacy of Acarbose, it is not well known in the west— and many pharmacies

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have to “special order” it for my patients. Consequently, I was surprised to learn recently that alpha glucosidase inhibitors like Acarbose are the most popularly prescribed glucose-lowering agents in China. (29).

16. Stolk, R.P., Breteler, M.M.B., Ott, A., et al. Insulin and cognitive function in an elderly population. Diabetes Care, 1997, 20: 792-5.

17. Chiasson JL, Josse RG, Gomis R, et al. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance—The STOP-NIDDM trial. JAMA, 2003:290;486-494.

18. Arungarinathan G, McKay GA, and Fisher M. Drugs for diabetes: part 4 Acarbose. Br J Cardiol 2011;18:78−81.

19. Puls W, and Krause HP. Delay of carbohydrate absorption by inhibitors of intestinal alpha-glucosidases. Advances in Experimental Medicine and Biology, 1979, 119: 341-346.

20. Calle-Pascual, A., Garcia-Honduvilla, J., Amrtin-Alvarez, P.J., et al.

Influence of 16-week monotherapy with acarbose on cardiovascular risk factors in obese subjects with non-insulin-dependent diabetes mellitus: a controlled, double blind comparison study with placebo. Diabete Metab, 1996, 22: 201-2.

21. Johnston, P.S., Lebovitz, H.E., Coniff, R. Advantages of monotherapy with alpha-glucosidase inhibitors in elderly NIDDM patients. Diabetes, 1997, 46 Suppl 1: 158A. 22. Goto, Y., Nakagawa, S., Goto, Y., et al. Clinical utility of BAY g 5421 (acarbose) on NIDDM. Multicentre double-blind comparative study. Igaku no Ayumi, 1989, 149: 591-618.

8. Akazawa, Y., Koide, M., Oishi, M., Azuma, T., and Tashiro, S. Clinical usefulness of acarbose and fiber in the treatment of diabetes mellitus. Therapeutics, 1982: 36: 848-9, 870-5.

23. Williams-Olsson T. Alpha-glucosidase inhibition in obesity. Acta Medica Scandinavica, 1985, 706 (Suppl 1): 1-39.

9. Hoffman, J., and Spengler, M. Efficacy of a 24 week monotherapy with Acarbose, metformin or placebo in dietary treated NIDDM patients: The Essen-II study. Am J Med, 1997, 103: 483.

24. Williams-Olsson T., Krotkiewski, M., Sjostrom, L. Relapse-reducing effects of acarbose after weight reduction in severely obese subjects. J Obesity and Weight Regulation, 1985, 4: 20-32.

10. Nuttall FQ. Effect of age on the percentage of hemoglobin A1c and the percentage of total glycohemoglobin in non-diabetic persons. J Lab Clin Med, 1999, 134: 5, 451-453.

25. Li C, Hung YJ, Qamruddin K, et al.

International noninterventional study of Acarbose treatment in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2011. Apr;92(1):57-64.

11. Coniff, R.F., Shapiro, J.A., Robbins, D., et al. Reduction of glycosylated hemoglobin and postprandial hyperglycemia by Acarbose in patients with NIDDM. Diabetes Care, 1995, 18: 817-24.

26. Yang W, Liu J, Shan Z, et al.

Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial. Lancet Diabetes Endocrinol. 2014;2(1):46–55.

12. Philip E, Sundaram ML, Das R, et al.

Acarbose improves glycemic control as add-on or monotherapy in Indian type-2 diabetes: Findings from the GlucoVIP multinational observational study.

Indian J Endocrinol Metab. 2013: 17; 9, pp.674-679.

27. Hillebrand, I., Boehme, K., Frank, G., Fink, H., Berchtold, P. The effects of the alpha glucosidase inhibitor BAY g 5421 (acarbose) on meal-stimulated elevations of circulating glucose, insulin, and triglyceride levels in man. Research in Experimental Medicine, 1979, 175: 81-86.

13. Magner JM, and Amatruda JM. Alpha glucosidase inhibitors in the treatment of diabetes, in: Diabetes Mellitus: A Fundamental and Clinical Text, by: LeRoith D, Taylor SI, and Olefsky JM (eds), 2d ed, Lippincott, Williams & Wilkins, 2000.

14. Balfour JA, and McTavish D. Acarbose—An update of its pharmacology and therapeutic use in diabetes mellitus.

Drugs, 1993, 46 (6): 1025-1054.

15. Bischoff, H. The mechanism of alpha glucosidase inhibition in the management of diabetes. Clin Invest Med, 1995, 18: 303-11.

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28. O’Dea, Kerin, and Turton, Janice.

Optimum effectiveness of intestinal alpha-glucosidase inhibitors: Importance of uniform distribution through a meal.

American J Clin Nutr, 41: March, 1985, 511-516.

29. Standl E and Schnell O. Alpha-glucosidase inhibitors 2012—Cardiovascular considerations and trial evaluation.

Diabetes & Vascular Disease Research 2012:9(3);163-169.

• Acarbose fights diabetes, weight gain and aging!

• Acarbose helps to prevent the breakdown of carbohydrates in the stomach into sugars.

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Acarbose

The almost forgotten role of the thymus

By Phil Micans, MS, PharmB

The thymus gland is small in size, weighing no more than 1.5 ounces and is located in the upper region of the chest.

Its importance in the regula-

tory function of the immune system was recognized in the 1960’s, when thymus gland removal in animals resulted in a distinct and progressive

depression of the immune system and when left unchecked, usually resulted in the death of the animal from an uncontrollable infection.

Age related disease

Thymus dependent immunity Diseases of childhood

Blood thymosin levels

0 5 10 15 20 25 30 35 40 45 50 75 80 85 Years

12

Figure 1: Shows the relation between a decrease in blood levels of thymic peptides and the direct correlated increase with thymus dependant immunity and its increase on age related diseases.

Published by the World Health Organisation, technical report series, 630 (1978).

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However, when thymus tissue was implanted into such animals, partial or complete recovery took place.

Important insight was gained from experiments with thymectomised animals in which, instead of a new thymus implant, an infusion chamber was implanted, (which did not allow cells to pass through). When thymus tissue, or a cell free thymus extract was placed in these chambers, the immune

system function of the animals also improved. This helped to prove that water soluble thymic substances, not associated with intact thymic cells, can considerably influence immune defense (1).

Later research demonstrated that the thymus gland produced a family of specific immune-regulatory polypeptides, known collectively as thymic hormones. It has also been shown that other organs (i.e. the spleen), also synthesis similar peptides (2).

The precise mechanism of action of these thymic peptides has still not been fully elucidated. There is however, no doubt that the involution of the thymus gland, which starts very early, often at puberty, is associated with a decrease in thymic function and a weakening of the immune defense system in elderly individuals (3, 4).

Figure 2 shows the reduction in the number of joints afflicted with pain, (which is elicited by movement and by pressure for rheumatoid arthritis sufferers), when treated with Thym-Uvocal ®. There is a very significant improvement within 6-weeks which continues past 74-weeks.

search has demonstrated that the thymic hormones have a marked effect on the maturation and differentiation of T-cells. The great significance of the T-cell system for immune defense is also well documented. For whilst increasing age is associated with a generalized weakening of immune defense, the decrease in the function of the T-cell system appears to play the greatest role in the overall decrease in immune defense.

Furthermore, thymus hormones are known to reduce autoimmune reactions and help to prevent bone marrow injury, by assisting the production of white and red blood cells (5).

It has also been shown, that thymectomy in older persons, accelerates in a lasting manner, the age related decrease in the immune system (2). More recent re-

So as the thymus gland begins to atrophy (shrink/

Number of joints (N=60/ 17) 20 18 16 14 12 10 8 6 4 2 0 0 2 4 6

Weeks

68

70

72

74

decline) by the age of 20, it is Thymus and allergies considered to be a major bioMeanwhile, whilst thymus marker of aging (6). Therefore, hormones increase antibodas Figure 1 indicates, the reies where they’re needed, they duction in thymus hormone have also been shown to be production is considered to able to reduce the levels of the be a major link between a “allergy antibody” IgE, thus decreasing immune system having benefits for patients with advancing age. suffering with allergies such as allergic rhinitis, asthma But interestingly, thymus and atopic dermatitis, etc. (5). gland hormones do not increase all immune function Thymus and growth activity, but rather appear to hormone be able to actually reduce im- Furthermore, some of the munity where it is excessive, health benefits of thymus (as seen by high T4/T8 ratios hormones may be due to a in rheumatoid arthritis). For relation between the thymus while thymus hormones and the pituitary gland. The improve immune function pituitary gland is the center where it is weak, (i.e., low T4/ of production for growth horT8 ratios in HIV), thymus mone and thymus hormones. hormones have been shown By increasing the number to be able to normalize the and activity of T-cells, this T4/T8 ratio to the “ideal” enables T-cells to secrete healthy T4/T8 ratio of 1.74 (7). growth hormone releasing

By Leslie J Farer

hormone (8, 9).

Minutes (N=60)

Minutes (N=17)

160

160

140 120 100

140 120 100

80 60

80 60

40 20 0

40 20 0

0

2

Weeks

4

6

68

70

72 Weeks

74

Figure 3 shows the reduction in morning stiffness for rheumatoid arthritis sufferers when using Thym-Uvocal ®. There is a marked improvement within 6-weeks which continues on past 74-weeks.

This may help to explain some of the anabolic changes seen in patients who are undergoing thymus hormone supplementation. Certainly it is noted that when the thymus gland is removed, it is accompanied by degeneration

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13

Tissue from any given animal is only used after a veterinary physician has examined the live animal and issued a certificate of good health.

Before the tissue is processed, histological and bacteriological tests are performed.

During the multi-stage processing, proteins and prohormones in the tissue are enzymatically cleaved to short-chain pharmaceutically active oligopeptides.

Thymus Hormones

Immune Defense

Conflicts Stress

Disease

Figure 4: The connection of thymus hormones to immunity, disease and stress.

in pituitary cells (2) with a resultant catabolic action.

Thym-Uvocal ®, a whole natural thymus product from Germany However, it has not been shown that one can isolate a single thymic hormone with the whole complex of functions of the thymus gland. It would rather appear that single isolated molecules carry out single psychological functions, (e.g. T-cell differentiation), but not other functions. For this reason, it is still considered appropriate to produce and administer a natural, complex mixture of extracted thymus hormones, capable of comprehensive modulation and stimulation of immune defenses.

14

The Germany Company, Strathmann AG, have a long-established product called Thym-Uvocal ®, which is known to be an effective whole and natural thymus hormone agent that is very well tolerated, with impressive actions in those disease states associated with impaired immune defenses, including “old age.”

Thym-Uvocal ® is not just a desiccated whole thymus glandular extract, of the type found in health food stores.

The active substances in Thym-Uvocal ® are obtained by a selective, multi-stage biotechnology process. The starting material is thymus glands from strictly selected and healthy calves, raised in Australia.

Then filtration and special heat treatment ensure the inactivation and removal of any microorganisms. The controlled and reproducible manufacturing process produces an activation and concentration of the desired low molecular weight peptides.

The various thymus gland hormones range in their molecular weight from 860 Daltons (Thymulin) to 5600 Daltons (Thymopoietin), and since animal experiments and human clinical research has found no single thymus gland hormone to be capable of performing all the immune optimizing functions induced by the thymus gland hormones as a whole, a pharmaceutically balanced thymus gland polypeptide hormone mixture is both more “natural,” and more likely to be safe and effective, than any single specific thymic hormone, (10).

It is interesting to note, that Thym-Uvocal ® has been

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used clinically in Europe since 1976 and still represents one of the finest thymic supplements available anywhere on the world market today.

Thym-Uvocal ® and cancer The main indications for Thym-Uvocal ® have been to strengthen the immune system, particularly in patients with malignant disease. The immune system is partially or completely impaired in patients with malignant tumors, particularly if they are also being treated with cytostatic drugs and/or radiation.

Thym-Uvocal ® has been administered along with treatment, and has reduced side-effects, with no interactions or contraindications being reported to date. Many physicians have also reported improvement in the underlying disease, with regression of existing tumors, a delay in metastasis and better remission times (13).

Possible positive effects on the underlying cancer disease with Thym-Uvocal ® include:

1. Regression of an existing 2.

3.

4.

tumor.

Delayed metastasis.

Prolonged remission time.

Improvement in the quality of life.

Thym-Uvocal ® and rheumatic disease In the area of rheumatic disease, Thym-Uvocal ® can being about subjective and

objective improvement, leading to both a reduction in inflamed joints and reduction in the number and severity of painful joints (shown in figures 2 and 3).

Both specialists and general practitioners very often report astonishing objective improvement in their patients. This has included less disability, better mobility and reduced swelling of the joints.

It is assumed that the com- Frequent reports include bination of active substances the ability of Thym-Uvocal has a positive immunomod® administration to allow ulating effect on the autoimlower doses of non-steroidal mune processes. Our attenanti-inflammatories, and that tion here is focused upon long term use has allowed patients who cannot tolerate them to wean rheumatism the usual doses of non-stepatients off steroids (11). roidal drugs used in rheumatism, or in whom such drugs Conclusion no longer have the desired Immuno-incompetence effect. Administration of can result from disease and Thym-Uvocal ® can make vice-versa. Some drugs can it possible in many cases to treat disease, but weaken the decrease the effective dosage immune defense systems of non-steroidal anti-inflamat the same time. Physical matories, and/or prevent a and psychological stress can switch to steroids. cause disease directly, or do The possible improvements in rheumatism with Thym-Uvocal ® include:

1. Reduction in morning 2.

3.

4.

5.

stiffness.

Increase in locomotor activity.

Increase in mobility.

Positive change in laboratory findings.

Reduction of pain.

the same indirectly by causing immuno-incompetence, (see figure 4).

As is shown in figure 1, there is a close correlation between decreasing thymic activity, worsening immuno-competence and increasing susceptibility to disease as we grow older. As it is known that blood thymus levels decline after the age of

25, this helps to explain why older individuals are the most important group for supplementation with thymus, yet the thymus gland is virtually completely overlooked by mainstream medicine, even by some in the field of endocrinology!

There is no doubt that the thymus gland appears to be the most forgotten about gland in medicine today!

Yet, because of the immune stimulation induced by Thym-Uvocal ® supplementation, it has been applied for a number of different indications which all involve immune system decline. These include infections (viral and bacterial), allergies and states of exhaustion (chronic fatigue), Aids, cancer and arthritic disorders.

An interesting comment was made by biochemist James South MA, who noted in his article (12); “the overlooked but vital role of the thymus”, that in addition to its immune enhancing properties, the personal use of Thym-Uvocal ® for himself and his wife, induced a state

There is no doubt that the thymus gland appears to be the most forgotten about gland in medicine today!

of “well-being” and had “vitalizing” effect on them both.

The dosages depend upon the need, and vary from 1 capsule (240mg each) twice a day, to 2 capsules three times a day. Its effects can normally be noted within 3-7 days.

Side-effects are very rare and to date no known contraindications have been reported.

References 1. Goldstein et al. “Thymosin and the Immunopathology of Aging.” Federation Proc., 33, 2053-56, 1974.

2. J. Goss & M. Flye. “The Thymus Regulator of Cellular Immunity.” Austin: R.G. Landes Co. 1993.

3. M. Sztein et al. “Modulation of Interleukin 2 Receptor Expression on Normal Human Lymphocytes by Thymic Hormones.” Proc. Nat. Acad.

Sci. USA, 83, 6107-11, 1986.

4. M. Zatz & A. Goldstein. “Mechanism of Action of Thymosin.” J. Immunol., 134, 1032-38, 1985 5. N. Kouttab et al. “Thymomodulin: Biological Properties and Clinical Applications.” Med. Oncol. and Tumor Pharmacother. 6, 5-9, 1989.v 6. R. Klatz & C. Khan “Grow Young with HGH” NY: Harper Collins 1997.

7. P. Cazzola et al. “In Vivo Modulating Effect of a Calf Thymus Acid Lysate on Human T Lymphocyte Subsets and CD4+/ CD8+ Ratio in the Course of Different Diseases.” Curr. Ther. Res., 42, 1011-17, 1987.

8. D. Weigant and J. Blalock. “Immuno-reactive Growth Hormone- Releasing Hormone in Rat Leukocytes.” J. Neuroimmunol. 29, 1-13, 1990.

9. K. Kelly et al. “A pituitary- Thymus Connection during Aging.” Ann. N.Y. Acad. Sci. 521, 88-98, 1988.

10. Thym-Uvocal, Immunotherapeutic Agent; A 32 page booklet published by Medalfa AG, Pratteln, Switzerland, 31 references plus many case histories.

11. Z. Fahmy. “Immuno-stimulation therapy with Thymus Extract in rheumatoid arthritis.” A journal of medical practice (in German titled- Erfahrungsheilkunde), Vol. 31, No 5, May 1982, pp. 423-427.

12. J. South, “The thymus gland, its overlooked but vital role.” IAS Anti-Aging Bulletin, v3, i6, Fall 1998, pp 7-15.

13. Procedures of the International Thymus Consensus Conference, “Therapeutic relevance of thymic peptides in the treatment of tumor patients.”

Quarnbek, Germany, April 12-13, 1997

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Beating the flu season An interview with Richard Stead about the power of OSCN Richard Stead is a British chemist who has introduced oxythiocynate ions (OSCN) as a supplement to the world. OSCN is a natural molecule in the human body that appears to literally represent the body’s first line of immunity.

In an age of the ever-growing threat of viruses and pathogens and the failing of established antibiotics, Phil Micans (PM) interviewed Mr Richard Stead (RS) about how OSCN may be one possible answer to bolster immunity.

PM: Richard thank you very much for your time today to help explain the work you’ve been doing.

RS: My pleasure Phil.

PM: I suppose the first question to ask is why did you look at the OSCN molecules in the first place?

RS: Our original interest was for a technology to replace Chlorine as an antibacterial wash for cut and prepared vegetables, and maybe even fresh meat. The technology worked very well--as good as was achieved by the chlorine based systems, but also a great deal safer for workers, the environment and the actual foods.

PM: So why hasn’t the food industry adopted them?

RS: Chlorine is a very cheap material. Although ours worked out to be 5 times more expensive than chlorine--and 5 times cheap is still relatively cheap—and despite the fact that the supermarkets and the processors liked the product, neither would agree to bear the additional costs. So we failed to enter the food market. I had always told the processors that if one of their workers fell into our wash water they would come out healthier 18

than before they fell in. With this in mind I determined to use the technology to create an alternative to existing systems for pathogen elimination – an alternative to antibiotics as our first target, and then a system to remove airborne pathogens.

Grandmothers told us to chew our foods more was to ensure that saliva was able to get all surfaces of the food and destroy any pathogens.

Maybe our modern way of eating fast food too fast is the cause of numerous stomach bugs?

(referred to as dysbiosis) can lead to a wide range of brain/ mental and bodily malfunctions. Therefore, any medication that does good- without disrupting the gut flora is a real bonus.

PM: It is clear that ‘new’ viruses pose major threats

Ed. For more technical details

OSCN supplement before?

to world health, and leading scientists are regularly exclaiming that antibiotics are becoming less effective by the day. What can nature teach us?

RS: Indeed, Phil, I like to say “Nature has the answer--chemistry is the key,” and I do believe that OSCN is one of those answers.

PM: So where in the human body can one find OSCN molecules?

RS: Principally in saliva, airways, tears and mother’s milk.

PM: And what role do they play?

RS: The OSCN molecule is created on demand when necessary to destroy low levels of pathogens. We say low levels because it is to cope with those pathogens that come into our eyes or into our mouths, on our fingers or on foods. One reason our

and references please refer to Professor Paul Clayton’s article ‘The age of antibiotics is coming to an end’ in issue 1, 2012 of the Aging Matters™ magazine.

PM: Do OSCN have other advantages not attributable to antibiotics? The possibility of bacteria being able to develop resistance is almost zero.

RS: OSCN do not attack healthy gut flora. Why is this important? There is a growing acknowledgement that the microflora in our gut is related to so much of our wellbeing and as a consequence, any disruption

PM: With such benefits, why has there never been an

RS: It is hard to explain, but I have a couple of comments: First, it is hard to cover the technology of the molecule with a patent, and this alone would stop many pharma companies from looking at the product; second is the relative short stability of the molecule. This makes it difficult to be factory-produced and bottled or encapsulated.

PM: How did you overcome this issue?

RS: With difficulty, is the short answer, but we were determined. So with a great deal of creative thinking, de-

“...any medication that does good - without disrupting the gut flora is a real bonus...”

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sign and heart ache we finally achieved a system used by patients/caregivers to create the OSCN at the point/time of use PM: What sort of conditions have OSCNs been tested against?

RS: In laboratory conditions, the list of pathogens against which OSCN has been successful is huge. We are in the middle of clinical trials against 4 different conditions, plus, a further trial for Lyme’s disease is about to start.

PM: And what have been the responses from health professionals and patients using the kit?

RS: I cannot say we have been 100% successful, but almost all users have seen positive benefits and improvements in their conditions/symptoms.

Of particular success is gut dysbiosis. The removal of the overload of bad bacteria by OSCN has allowed sufferers to start to build up the good gut flora and then onto diets to rebuild their health. But the removal of the bad bacteria is essential as a first step.

Gut dysbiosis is evident in almost all sufferers of chronic conditions, for example, autism, MS, chronic fatigue, and many others.

PM: How does one dose OSCN? RS: The dosing regimens are difficult to determine. If we could know exactly how

many bad bacteria were present then a very accurate dosing schedule could be created. But until we have fast identity of the pathogen and measurement of bacterial loads, dosing has to be based upon a clinicians experience and knowledge of the patient.

We always try to bring down pathogen levels to a level at which the immune system can take over. Therefore, if a sufferer has had the condition for a long time (e.g. for many months or even years) then a higher dose is needed than for a recent infection. For people prone to regular infections, then maybe a monthly maintenance dose is an idea to consider. The effect would be to regularly reduce the build-up of pathogens that are always invading us and getting past our defences, but which are not yet at a level to cause symptoms.

PM: Have there been any side-effects or contraindications?

RS: None known in the low doses used. However, a good side effect identified often by chronic sufferers has been the Herxheimer reaction – that of the liver being overloaded by the poisons given off by dying and dead pathogens, killed by the OSCN. This good sign of efficacy lasts but a short time and most practitioners/clinicians can prepare the patient/ liver in advance.

PM: Some of the literature has suggested that OSCNs

“We always try to bring down pathogen levels to a level at which the immune system can take over.” can have a slight lowering effect on the thyroid, would you care to comment on that?

RS: Yes, we have read the papers. Our opinion is that it’s not affected in the doses that we advocate, i.e. one or two kits/ 25/50 mg per day.

But those concerned can easily offset this by adding a few drops of iodine daily, if they wish, or as is suggested by their practitioner.

PM: Are there any other steps that folks can take along with OSCN to make the program synergistic?

RS: We recognise that the effect of OSCN is to destroy pathogens. That on its own does not make the patient healthy. There is no residual effect after our molecule has been used and the patient could remain open to the same pathogen or other pathogens unless they take steps to improve their health and immune competence. This is an important aspect of working with Practitioners and clinicians. We are all different as individuals and so require

different diets to bring us back to good health. Phil, just before we finish, I am very excited about our trials that are near to their conclusion and hope that the results are good and that we will then be able to present one or more papers to medical magazines for them to publish. If the results are good, we will of course let you know, and then we will start new trials on other conditions and my idea is to look at airways and topical conditions. Maybe your readers have suggestions together with guidance where we can find support groups of sufferers of a particular condition willing to find new treatments?

PM: That’s very exciting, I am sure that our readers will want to know their details when they become available.

RS: It will be my pleasure to report once they are published, and thanks for allowing me this chance to talk about OSCN, the prospects for which I find so exciting.

PM: Thank you very much.

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19

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

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Pyridoxamine:

A universal weapon against aging

By Karen Kaufmann, MS

We are constantly being bombarded with messages from the media, the department of public health, and the World Health Organization (WHO) about how overweight and sedentary we have become.

The incidence of obesity has reached epidemic proportions.

Our growing waistlines coupled with our sedentary lifestyles have put us at risk for developing Type 2 diabetes as well as a host of other chronic degenerative diseases.

I raise this issue, because in the face of all this public discussion, it is easy to ignore the public health warnings, particularly if you are an individual of normal weight and consider yourself at low risk of developing diabetes.

Actually, when one looks at the disease Diabetes Mellitus (DM), it is apparent that what is truly occurring is an accelerated form of aging. Aging is occurring in all of us. It is important to make note of the many microvascular and macrovascular complications of diabetes because these complications provide us with clues from which we can form a logical and rational anti-aging protocol.

There are a number of different theories of aging. One of the oldest and best known theories is Denham Harman’s ‘free radical’ theory of aging which dates back to 1956. This theory posits that unpaired oxygen electrons, which are produced during aerobic respiration, cause cumulative oxidative damage, resulting in the effects of aging and death.

Harman posited that endogenous oxygen radical generation occurs within the body, as a by product of enzymatic redox chemistry.

Therefore the necessary ingredient for life – oxygen – is a double

edged sword. While we can’t live without breathing in oxygen, we cannot utilize oxygen without it damaging our cells.

Another theory of aging is Johan Bjorksten’s cross-linking theory of aging. The cross-linking theory of aging and the free radical theory of aging are not mutually exclusive, but synergistic. Ironically the cross-linking theory of aging is actually based upon processes described by the food chemist Louis Camille Maillard in 1912 who outlined the non-enzymatic chemical reactions between proteins and carbohydrates that cause foods to turn brown.

This process also occurs in the body when a reduced sugar (usually glucose) attaches to a protein.

An intermediate reversible product is formed. That product is a Schiff base. As the protein/ glucose complex continues to be exposed to additional sugar a more stable, less reversible complex forms. That complex is known as an Amadori product. Amadori products further degrade into a number of highly reactive carbonyl compounds.

These compounds are known as Advanced Glycation End products (AGEs) or when lipids or fats are involved Advanced Lipoxidation End products (ALEs). AGE/ALEs go on to react with other fats, proteins, amino acids, nucleic acids and a variety of other cells. AGEs in tissues increase the rate of free radical production, cause tissue injury,

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21

inflammation, and can deposit anywhere. For example, when AGEs attach to LDL cholesterol, the LDL cholesterol is rapidly oxidized and is more likely to deposit within a blood vessel thereby contributing to plaque formation and atherosclerosis.

AGEs form at an accelerated rate in hyperglycemia, diabetes, and metabolic syndrome.

However, AGEs are a universal symptoms of aging. They can deposit in any organ or tissue, including the skin, the lungs, the blood vessels, the lens of the eye, the neurons in the brain, and in the filtering mechanism in the kidney. Whenever and wherever AGEs deposit, the normal functioning of that organ, tissue or cell is compromised. There is evidence that AGEs can bind with DNA and have a mutagenic effect (contributing to the risk of cancer and autoimmune disease).

When we think of the formation of AGEs and ALEs we generally think of them forming endogenously as a result of the glucose that is already within the body. We often forget that there are also dietary AGEs and ALEs. Our exposure to AGEs and ALEs occurs as an end result of normal metabolism.

However we can also be contributing to the problem through the intake of dietary, exogenous AGEs. So, no matter who we are, how fit we are, how thin we are, we cannot escape the effects of these cross linked proteins.

Pyridoxamine Vitamin B6 exists in 3 naturally occurring forms: pyridoxine, pyridoxal and pyridoxamine (PM). Pyridoxine is the form most commonly seen in supplements. However, each can be phosphorylated at the 5 position.

Pyridoxal 5’ phosphate (PLP) and pyridoxamine 5’ phosphate (PMP) are the active coenzyme forms. Pyridoxine is found in plant sources. Pyridoxamine and pyridoxal are found in animal sources where they exist mainly in their phosphorylated forms.

All 3 forms have some ability to function as anti-glycation agents inhibiting the formation of AGE/

22

Pyridoxamine may prove one of our most powerful nutritional weapons in the war against chronic degenerative disease and aging itself.

ALEs, but it is pyridoxamine (PM) that is the most potent agent of the three forms.

Pyridoxamine prevents the formation of AGEs. It works by trapping reactive carbonyl groups and it also demonstrates free radical quenching properties. Accumulation of AGEs is a physiologic consequence of tissue aging. Tissue deposits of AGEs and circulating AGEs are a hallmark of diabetes mellitus.

Damage from AGEs is also seen in a variety of other vascular and degenerative diseases. AGE generation potentiates oxidative damage and lipid peroxidation in target tissues. The tissue damage caused by AGEs and ALEs further drives inflammation.

The more we understand about the role of AGEs in ‘normal’ global aging, the more important a pharmacologic agent like pyridoxamine becomes.

Pyridoxamine has multiple mechanisms of action which can are best summarized in a study published in 2005. “…PM inhibits post Amadori steps of the Maillard reaction by sequestering catalytic metal ions and blocking oxidative degradation on Amadori intermediate.

PM also has the capacity to scavenge toxic carbonyl products of sugar and lipid degradation, and to inhibit reactive oxygen species.” Pyridoxamine has been shown to limit the formation of AGEs without affecting glycemic control. There is additional evidence that high blood lipids contribute to the formation of AGE/ALEs even in the absence of hyperglycemia. Pyridoxamine inhibited the formation of both toxic end products demonstrating a protective effect on vascular and renal function in an animal model. It is quite unique that PM demonstrates the ability

to prevent lipid peroxidation and therefore ALE formation.

Pyridoxamine inhibited the formation of ALEs by trapping malondialdehyde (MDA) an important intermediate in ALE formation. The beauty of pyridoxamine lies not only in its multiple mechanisms of action, but also in its tolerability. There are little or no contraindications for its use.

The role of AGEs in health and disease There are a variety of chronic and degenerative diseases associated with the accumulation of AGEs in tissues and organs.

Many of these conditions we consider a normal part of growing older. The toxic AGEs can deposit anywhere compromising physiologic function.

AGEs deposit in the lens of the eye leading to the formation of cataracts. When AGEs deposit in the vascular system, long lived proteins such as collagen and elastin become stiff and hypertension is just one of many possible consequences. It is hard to envision a chronic degenerative condition or disease of aging that would not benefit from the inhibition of AGE/ALEs formation. “Although AGEs in proteins are probably correlative, rather than causative, with respect to aging, they accumulate to high levels in tissues in age-related chronic diseases such as atherosclerosis, diabetes, arthritis and neurodegenerative disease.” Inhibition of AGE formation could inhibit oxidative and inflammatory damage in target tissues, slowing the progression and pathophysiology of aging. This could lead to a significant improvement of the quality of life of the aging population. It is evident that AGE/`ALEs likely

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contribute to both diabetic and non diabetic vascular damage.

AGEs accumulate in tissues and organs in rheumatoid arthritis and Alzheimer disease. As mentioned above, diabetes mellitus provides us with a model of accelerated aging. AGE/ALEs contribute to the various microvascular and macrovascular complications which occur in the disease.

Just as AGEs compromise the flexibility and efficiency in the vascular system, AGE deposition in the kidney compromise the kidney’s filtering capacity and can lead to nephropathy and kidney failure. Culling the most recent literature was enlightening. There is now evidence that AGEs may contribute to colon cancer and melanoma.

Pyridoxamine may prove to be a therapy for primary hyperoxaluria (which causes the formation of kidney stones.

AGEs may well interfere with osteoclast activity by altering the structural integrity of bone matrix proteins and osteoclast induced bone resorption, thereby contributing to an increased risk of bone fracture. There may even prove to be a link between AGEs and osteoarthritis (OA) the most common cause of chronic pain and disability in older adults.

Conclusion In conclusion, pyridoxamine may prove one of our most powerful nutritional weapons in the war against chronic degenerative disease and aging itself.

Pyridoxamine

RAREST AND MOST POTENT

FORM OF Pyridoxamine is the rarest and most potent form of the three naturally occurring B vitamins. It is particularly effective in the late stages of glycation and at reducing the formation of advanced lipoxidation end products (ALEs).

PyridoxPro (Pyridoxamine) 60 x 50mg Tabs $29.99 FOR A LIMITED TIME ONLY $24.99 SAVE $5 ON EACH PACK* *Offer valid until April 30th

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

VITAMIN B6

SPOTLIGHT: CAN-C

™

A B R E AK THROUG H FOR C ATAR AC T Can-C™ eye-drops are the original™ brand- developed by Innovative Vision Products (IVP). This group were the first to research, publish and prove how eye‑drops can reduce and even eradicate cataract. Accordingly there are active US and EU patents (and others pending) on this unique and special product.

Unique formula:

Clinical trial:

Improving eye-sight:

Can-C™ eye-drops are the formula from the original published human trials.

They contain a purified and racemized form of n-acetylcarnosine (made in Japan); this natural di-peptide has potent anti-glycating and antioxidant properties that prevents lipid peroxidation.

Note that the formula is important- it’s not all about the n-acetylcarnosine; the specific carrier agents and their purity are also important. If you look at the Can-C™ formula you will see differences to the copycats, (remember it is only Can-C™ that is patented in recognition of the original work). If you want the best possible results in the fastest possible time, then choose Can-C™ to deliver them according to the clinical trials.

Patients placed two-drops of Can-C™ into their eyes twice daily for a 6-month period, the outcome was:

More evidence is mounting that Can-C™ is efficacious for many conditions including:

• 90% saw an improvement in their visual acuity.

• 88.9% of patients showed

improvement in the clarity of their lens.

There have been numerous reports of cataract shrinkage and even disappearance with documented evidence that Can-C™ eye-drops remain effective (and safe) more than 24-months later. The most commonly expressed initial reports are that glare is significantly improved, (for example night driving is much safer) and color perception is enhanced.

• Cataracts (particularly the senile version) • Glaucoma • Presbyopia • Corneal disorders • Eye strain • Ocular inflammation • Blurred vision • Vitreous opacities and lesions • Diabetes mellitus complications • Contact lens users • Dry eye syndrome Of special interest may be to persons who wear contact lenses. This is because Can-C™ inhibits the accumulation of lactic acid and therefore contacts can be worn for longer periods without pain.

Before: Right: A woman’s eye shows the cataract before treatment.

Far Right: 5-months later after use of Can-C eye-drops (two drops twice daily), there is no longer a visible cataract and eyesight has improved.

Dr. Kyriazis book, ‘The Cataract Cure’, details the usefulness and evidence of Can-C™ eye-drops.

It is now available as a FREE e-book at:

www.antiaging-systems.com/can-c-ebook

24

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We have also received reports that Can-C™ not only aids dry-eye syndrome with its lubricants, but that Can-C™ helps to unclog proteins from the lacrimal ducts, thus releasing more natural tears onto the eye.

In a similar way, it is also believed that the unclogging of proteins in the eye’s drain, (the Schlemm valve), helps to reduce intraocular pressure and thus aids glaucoma.

Above: Can-C Plus capsules

After:

SPOTLIGHT: GHRPS A R E AL ‘OR AL’ ALTER NATIVE TO G H INJEC TION S Ever since Dr. Rudman’s work in the 1980s and then the release of Dr. Klatz’s book ‘grow young with HGH’ in the 1990s, there has been a strong interest in the use of growth hormone (GH) in antiaging medicine.

Dr. Rudman’s research concluded that after injecting his elderly patients with GH, many of them had reversals of their biological age markers by as much as 20-years; specifically having noted improved skin, hair, muscle mass, decreased fat levels and enhanced levels of stamina, strength and well-being.

It’s not entirely surprising given the multi-faceted role of growth hormone, plus as its name suggests it is involved in the growth and repair of tissues, but unfortunately blood levels of it decline dramatically past the age of 35 (see figure 1), despite the fact that there is evidence that the pituitary gland continues making significant amounts of it.

GH injections

The issue with injecting GH, (brand names include Genotropin®, Saizen® and Zomacton®), other than its expense, is that it does have to be injected to be effective, this is because as a 191 chain amino-acid it simply can’t be absorbed via any other route, thus daily injections can become a chore.

Furthermore, many countries have decided that GH injections be classified as a controlled substance, partly because of its anabolic actions.

Controlled substances often require special import and export licenses; this is overand-above the requirement for a prescription.

Furthermore, the research of Dr. Richard Walker has highlighted that bolus injections of GH are not

bioidentical and that as they induce spikes of GH into the blood they could end up damaging the pituitary gland, leading to a down-regulation of its own production of GH, or even to stop GH production altogether.

GHRPs

But meanwhile, Dr. Walker’s research has shown that the use of GHRPs, (growth hormone releasing peptides) have a much safer profile whilst enjoying the same benefitseven if they provide them a little more slowly. We would recommend that you read his extensive article in the Aging Matters™ magazine, No3, 2014 to understand fully how they operate. What we can say is that GHRPs, (GHRP2, GHRP6 and sermorelin) have the following benefits: • They can be sublingually, intra-nasally and even orally, passing into blood and thus avoiding the need for needles.

• Their feedback loop means that they cannot cause the pituitary to down-regulate.

• GHRPs are not controlled substances.

• Rather than inducing a spike of GH in the blood, GHRPs augment (improve) each release of GH naturally into the blood, for which there are several peaks daily, (although the rising from bed peak is the highest one) - see figure 2.

Synergy

Sermorelin is actually the precursor to GH, being the first 29 amino acids and is

applied via the sublingual route.

Sermorelin’s function may be to release existing stores of GH from the pituitary- rather than encourage more production as a pure agonist would. Dr. Walker has highlighted that combining sermorelin with GHRP2 or GHRP6 has a highly synergistic effect, in some cases eliciting up to a 5x greater quantity of GH into blood, an action that can be equivocated to using injectable GH itself.

Note: You can also hear Dr. Walker discuss this with us on the IAS video page.

who want to put on muscle mass.

• GHRP2 may create less hunger feelings and therefore could be preferable to those who want to stimulate GH for fat loss. Also as the GHRP6 (Releasing-Pro™) is a nasal spray, those who don’t like that feeling may prefer GHRP2-Pro™ since it is an oral liquid simply swallowed.

Summary

GHRPs have created a genuine efficacious alternative; they are simpler/ easier to use and at the same time they have a better/ safer profile than injectable GH.

Differences

There is no definitive answer yet as to the specific differences between GHRP2 and GHRP6; our own experiences, including information received from physicians and patients who use these products suggests the following: • GHRP6 may induce more hunger feelings than GHRP2 and could improve levels of IGF-1 more. Therefore this option may be better recommend for those Figure 1 (top): The typical GH levels in blood with age, note that ‘geriatric’ levels are reached as early as during the 30’s. Figure 2 (middle) shows the 24 hour profile of subcutaneous (and also intravenous) GH. Compare that to figure 3 (bottom), the natural peaks of GH in both young and elderly patients. Only GHRPs naturally amplify these bioidentical patterns.

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25

SPOTLIGHT: THYROID SUPPORT FOR THE HYPOTHYROID EPIDEMIC Dr. Broda Barnes in the 1970s estimated that 40% of the adult population was deficient in thyroid hormones; he published this statement in his excellent book‘hypothyroidism, the unsuspected epidemic.’ Since then, pupils of Dr. Barnes, such as Dr. Richard Wilkinson, have suggested that this figure could be even greater now!

This is important because the thyroid gland is of pivotal importance to our overall health, but like the majority of hormones as we age the production of thyroid hormones decline. This lack of thyroid function is the root cause of a wide variety of agerelated health disorders.

Ergo, supplementation with a synthetic or a natural thyroid can have a significant positive effect on a wide range of age-related problems.

The importance of the thyroid gland The hormones produced by the thyroid control the body’s metabolism- the rate at which it burns calories for energy. It also controls the body’s utilization of fat, so a decline in the secretion of hormones from the thyroid gland, (known as hypothyroidism) can result in wide range of symptoms such as poor concentration, confusion, memory problems, cold hands and feet and weight gain.

Another serious condition which can be caused by and result from an underactive thyroid are painful musculoskeletal issues that affect tendons, muscles and ligaments.

How can I be sure if I need a thyroid supplement?

Above: The position of the thyroid gland

thyroid checked, but another, simpler method is to take your body temperature when you wake in the morning. It should be in the range of 97.8 to 98.2 degrees Fahrenheit, if it is regularly lower you could be hypothyroid and if higher then hyper-thyroid.

Choosing between synthetic and natural thyroid supplements IAS stocks a comprehensive range of both synthetic and natural thyroids, although we advocate the use of a natural supplement over a synthetic, this is because products such as Armour® are of a porcine origin, so they naturally contain the full spectrum of T1, T2, T3 and T4 thyroid hormones, (note the bottles only list the amounts of T3 and T4 because very few physicians are familiar with T1 and T2).

Natural desiccated thyroids are measured in grains; with one grain being equivalent to approximately 60 mg.

IAS carries doses from ¼ grain to 2 grains, with brands including Armour®, ERFA® and Nature®. IAS also provides synthetic T3 in 20 mcg and T4 in 100 mcg tablets.

Thyroid supplements provide potent antiaging protection Many aging individual can benefit from taking a thyroid supplement because this remarkable hormone has such a profound affect across so many different conditions. Many antiaging physicians consider thyroid support an essential part of any serious attempt to improve a person’s healthspan and longevity.

Apart from recognising the types of effects listed above, your doctor can of course get your blood levels of

Conversion between synthetic and natural thyroid products The table provided is a helpful guide to what the suggested conversion rates are for those wishing to make the switch between synthetic thyroids and natural versions. As always we recommend consulting with a physician before making changes to your program.

26

Thyroid doses

Dose of T4 (levothyroxine) (mcg)

Dose of Desiccated thyroid (grains)

Equivalents (mg)

Dose of T3 (lithyronine) (mcg)

0.5

32

12.5

50

1

65

25

100 200

2

130

50

3

200

75

300

4

260

100

400

5

325

125

500

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SPOTLIGHT: PEPTIDE BIOREGULATORS THE DI SCOVERY OF G ENE SWITCHES IN FOOD Today Professor Vladimir Khavinson is the President of the European Academy of Gerontology and Geriatrics, but in the 1980’s he was a Colonel in the Soviet Union military medical corps. At the time, he and his team were approached by Kremlin officials, they wanted them to find a way to protect their troops from a myriad of problems; issues such as radiation for submariners in nuclear submarines to troops that may be blinded from known, (but thankfully unused) new weapons such as battlefield lasers.

A former Soviet military secret!

What their research uncovered - that was used for two decades on many thousands of men and women - was a remarkable link between short chain peptides and DNA. This former military secret is now available to the public as peptide bioregulators.

Their published research has identified that each organ / gland / tissue uses a highly specific short chain peptide, obtained from food, to act as a ‘short-cut’ to initiate protein synthesis. These peptides, unlike proteins, can enter the blood through the stomach.

Through a comprehensive list of patents and even copyrighted PowerPoint slides, the Russian research group have shown that each of the concentrated

Above: A short-chain peptide bioregulator interacting with DNA

peptide bioregulators so far examined, interact with particular strands of DNA - effectively and very specifically activating repair and regenerative processes.

This is a remarkable story since what we are describing here are peptides that act as individualised gene switches.

To date, they have been tested for many years on thousands of individuals, without report of any serious side effects or contraindications. We believe that they could be set to ‘out do’ stem cells. Why? Because this peptide therapy is relatively cheap, highly specific, can be taken orally and doesn’t require any suppression of the immune system to operate fully (as stem cells do).

Original material from the trials The peptide bioregulators available via IAS are the bovine originals; sourced from carefully chosen Danish calves and processed through pharmaceutical processes and filters. They are not the synthetic versions which have not been studied/ proven.

Peptide bioregulators act as they sound- to regulate; for example, Thyreogen®

the thyroid peptide would increase thyroid activity if it were too low, but decrease it if it were too high!

Dosing Doses are very dependent upon the need and unlike hormones these peptides do not have to be taken every day, hence making them a cost effective regime. A typical/ average use could be considered as follows:

• Start with an intensive course: 2 capsules once a day for 30-days.

• Thereafter use 2 capsules once a day for 10-days, repeat every 2, 3, 4 or even as little as 6-months.

The story of the peptide bioregulators is a remarkable one and we recommend that you to read the articles and interviews and see the video on the IAS website.

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brain peptide bioregulator. heart peptide bioregulator. bladder peptide bioregulator. pineal peptide bioregulator. adrenal peptide bioregulator. muscle peptide bioregulator. prostate gland peptide bioregulator. kidney peptide bioregulator. cartilage peptide bioregulator. pancreas peptide bioregulator. stomach mucus peptide bioregulator. liver peptide bioregulator. lung peptide bioregulator. testes peptide bioregulator thyroid peptide bioregulator. blood vessel peptide bioregulator. retina peptide bioregulator. thymus peptide bioregulator. ovary peptide bioregulator.

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27

SPOTLIGHT: SMART DRUGS AND NUTRIENTS PIR ACE TAM, THE ORIG INAL NOOTROPIC Smart drugs and nutrients, or to give them their correct medical terminologynootropics, are agents that can not only improve conditions of senile dementias, but in recent times have become popular for older individuals to improve their mental and cognitive processes. It was Ward Dean, M.D. who highlighted these facts through his very popular ‘Smart Drug’ series of books in the 1980s, since then the term ‘smart drugs’ has become mainstream.

Piracetam, the original nootropic The smart-drug we focus on here was in fact the first, developed as it was

by Dr. Giurgea for UCB laboratories in Belgium in the 1960s. Originally it was designed to assist with travel and altitude sickness, but shortly afterward individuals realised that piracetam had positive cognitive enhancement effects.

What can piracetam do for me?

Piracetam is a cognition agent that has been used successfully to treat a wide

range of conditions, for example it has been shown to increase a person’s attention levels and improve memory and intelligence.

Piracetam can help to slow down ‘senile involution’, dementia and Alzheimer’s disease. In tests and trials, piracetam induces significant improvement to memory consolidation and recall in those suffering from ‘age-associated memory impairment’.

Piracetam has also been used to improve patient’s recovery from strokes, particularly improving post stroke speech impairment (aphasia). Another use has been in cases of acute and chronic cerebral ischaemia, (decreased blood flow to the brain). Using piracetam has restored speech and the use of limbs in these patients; it has also increased neuronal activity in the brain when measured with EEG. For regular individuals, piracetam has been shown

to enhance idea creation and the ability to ‘see things through,’ in other words to have ideas and being them to fruition. The level of clarity piracetam creates is often described/ perceived as; “the fog has lifted.”

How does piracetam work?

Piracetam’s key and unique method of action is upon the Corpus Callosum, the region of the brain that links the two hemispheres. It is this that most experts believe is the key that gives piracetam users the ability to channel greater brain potential by connecting the logical side of the brain with the creative side more effectively, Yin and Yang if you will.

“Piracetam can help to slow down ‘senile involution’, dementia and Alzheimer’s disease.”

28

Right: The Corpus Callosum

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What are the doses of piracetam?

A common dose is 800mg tablets three times a day, then lowering to 800 mg twice a day after the first month. Note: The effects of piracetam can be enhanced if taken concurrently with centrophenoxine or Hydergine®.

Side effects are minimal and seldom experienced, but should you experience nausea or headache then it is usually caused by an overdose, so in which case reduce the dose and build up more slowly, (if it is necessary).

Note: There are many articles and videos on the IAS website about smart drugs and nutrients.

SPOTLIGHT: BIOIDENTICAL HORMONES NATU R AL ESTROG EN S AND PROG ESTERONE FOR WOMEN IAS carries a wide range of bioidentical hormones - a term that means ‘natural to and in the body’. In this featured section we are focusing on the use of natural estrogens and progesterone for women, which of course are normally utilised to aid the menopause.

When hormone replacement therapy (HRT) was developed in the 1920s, estrogens had to be derived from horse urine because a laboratory solution was too difficult/ expensive to synthesize. But today everything has changed, yet this ancient practice continues- these facts have been pointed out by Dr. Wright in his best-selling book ‘Stay Young & Sexy’ Horse estrogens are, as you might expect, not identical to human; after all humans don’t have manes nor do they have hooves!

Yet the industry is stuck in this old loop, despite the fact that natural (bioidentical) estrogens can be easily produced now. Some people believe that the known side-effects from ‘traditional HRT’ are due to the fact that the hormones given are not correct.

Esnatri™, a unique tri-estrogen Esnatri™ is our bioidentical triple estrogen cream, which many women use, confident they have chosen the best bioidentical estrogen cream available. It comes directly from the work of Dr. Wright who has shown that the majority of women produce estrogens in the ratios of 90% estriol, 7% estrone and 3% estrone.

Above: As Dr. Wright himself has said many times; “we only have to copy nature, the right molecules at the right times and doses.”

Most tri-estrogen preparations attempt to replicate the human hormones estriol, estradiol and estrone, apply them in the ratio of 80:10:10, while some even entirely over-

Above: Stay Young & Sexy

By Dr. Wright

look estriol, claiming it is a weak estrogen. But, women naturally produce high levels of estriol and it is considered to have anticarcinogenic effects.

Esnatri™ use The Esnatri™ cream can be applied by daily rotation to your neck, upper chest, breasts and behind the knees, or inner thighs. A typical starting dose is 2 mg, start from day one (of what would have been the start of your menstrual cycle) and continue until day 25.

Then you should stop for five days, before repeating the application at the start of the next menstrual cycle.

During these last few days, the estrogen receptors are being allowed to ‘rest’ as they have been accustomed.

Progesterone Progesterone is the counterbalance to estrogens.

Indeed, whilst women can significantly decline in estrogen levels during menopause- they rarely reach zero production levels, whereas progesterone can

sometimes not be measured at all in elderly women.

It is also the low of progesterone that most significantly impacts bone strength, leading onto osteoporosis, so there are numerous reasons to ensure that progesterone is also taken alongside an estrogen therapy.

IAS provides a 5% strength natural progesterone cream. Typical doses are 25 mg to 30 mg of progesterone applied on day 10 and continuing to 25. The start date varies according to the usual timing of your ovulation. Note: As with the Esnatri™ cream, stop for the last five days of your cycle so that the estrogen receptors have their accustomed ‘rest’ period.

Remember, your hormone replacement therapy should be overseen by a physician and should not be undertaken if you have undergone cancer treatment.

“Esnatri™ is our bioidentical triple estrogen cream, which many women use, confident they have chosen the best...” www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

29

®

90 58

3mg Amount Per Serving

* % Daily Value

Servings per container: 60 Serving Size: 1 tablet

Supplement facts:

Description: MZS is Dr. Walter Pierpaoli’s original melatonin formula containing the additional and supportive agents zinc and selenium. MZS is produced to pharmaceutical standards in Italy and unlike other melatonin preparations MZS has been designed to produce a night peak of melatonin between 1AM and 3AM to mimic the natural behavior of the pineal gland.

Dr. Pierpaoli’s extensive animal and human research has shown that this is important because this action helps to stabilize circadian rhythms, improve hormonal cyclicity and boost immunity.

MZS

www.profound-products.com

Dr. Pierpaoli’s original formula+

™

Formulated and distributed by Profound Products, PO Box 19, Sark GY9 0SB, Great Britain

MZS Dr. Pierpaoli’s original formula ™

Dr. Pierpaoli

MZS Dr. Pierpaoli’s original formula

®

®

Dr. Pierpaoli MZS Dr. Pierpaoli’s original formula

™

Directions: Take 1 tablet before bedtime, ideally between 10PM and 11PM.

50mcg 8.7mg

Melatonin

Dr. Pierpaoli MZS Dr. Pierpaoli’s original formula

Disclaimer: This product and its statements have not been evaluated by the FDA. This product is not intended to treat, cure or prevent any disease.

% Daily Value * not established Other ingredients: Avicel, mannitol, povidonum and magnesium sterate Selenium Zinc

B EC AU S E NOT ALL MEL ATONIN S AR E CR E ATED EQUAL

Note: Keep in cool dark conditions, out of the reach of children and consume before end of expiry date. Not for use by pregnant or lactating women.

SPOTLIGHT: MZS

™

™

Our melatonin has been formulated by the world’s foremost melatonin expert Dr. Walter Pierpaoli, his Melatonin Zn Se, or MZS™, is totally unique since it is designed to mimic the natural night peak of melatonin- to leave you feeling refreshed and alert the following day.

What does Melatonin do?

Melatonin is vital to protect our hormonal system, regulate immunity and repair our body’s cells. It is commonly used by shift workers and also to treat jet lag and age related sleep disorders, but its abilities go far beyond simply its sleep inducing properties.

The antioxidant effects of melatonin Melatonin is an extremely effective antioxidant; in fact on a molecule to molecule basis; melatonin has proved to be significantly more efficient in neutralizing toxic

hydroxyl-radicals than the two well-known free radical scavengers, glutathione and mannitol.

many showed reversal of their ARMD. Remarkably this was true for both the wet and dry forms!

Melatonin’s effects on longevity

Why is Dr. Pierpaoli’s MZS™ more effective than other melatonin supplements?

Melatonin’s effect on longevity is well documented; in fact laboratory tests on rats and mice have demonstrated that melatonin increased their lifespans by 20%. Experts believe melatonin is a vital antiaging product because of its positive effect on aging.

MZS™ and age-related macular degeneration Age related macular degeneration (ARMD) comes in two forms, wet and dry and is a notoriously difficult disorder to treat and is linked to blindness. A 24-month study, (published in NY Academy of Science, 2005, 1057:384-392) on 100 patients showed that after 3 months, the majority of patients taking 3 mg of Melatonin Zn Se nightly had halted the progression of their age related macular degeneration and at 6 months

There are three principal reasons, firstly it is of pharmaceutical quality at a dose of 3 mg, secondly it contains the synergistic ingredients of selenium and zinc, but thirdly and most importantly- it is designed to release at a very specific time. Dr. Pierpaoli’s research led him to perfect a formula that exactly mimics the pineal gland’s release of melatonin.

Thus means that MZS™ is the only melatonin supplement to follow nature’s own night peak.

+

60 tablets Dietary Supplement

™

Melatonin is produced by the pineal gland at night to regulate our circadian rhythm, (sometimes called the sleep wake cycle). As we age the amount of melatonin we produce reduces resulting in many older people sleeping less and having a lower quality of sleep.

Dr. Pierpaoli

®

MZS Dr. Pierpaoli’s original formula ™

Dr. Pierpaoli

®

MZS™ is so much more than a sleep aid

Melatonin has had so many published benefits it is impossible to list them all here. From jet lag and shift work to well-being and antiaging, no other melatonin supplement offers the endorsement of Dr. Pierpaoli, or the exact formula used in all of his renowned clinical trials. If you’ve tried other melatonin and didn’t notice any significant effect, then we highly recommend you try Dr Pierpaoli’s MZS™ for a superior experience.

Dr. Pierpaoli’s free ebook ‘The key of Life’ can be read here:

http://bit.ly/1vdB31y

How much should I take?

Take half to one 3 mg tablet at bedtime only; do not take more than two tablets. By taking MZS™ between 9pm and 11pm you will create a night peak between 1am and 3am, this is the most natural and normal time to have the highest melatonin levels.

Left: Melatonin age decline graph

This graph compares Dr Pierpaoli’s melatonin formula (red line) to the natural release of melatonin (dark blue). Two other common types of melatonin supplements (light blue and green lines) demonstrate that sublingual melatonin peaks too soon and that time released formulas peak too late.

30

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Above: Here are some before and after Fundus photos showing the benefit of Melatonin Zn Se. (Top before, below: after treatment).

SPOTLIGHT: YOUTH GEMS

®

THE PEP TIDE B IOR EG U L ATOR S FOR S KIN Those who are already familiar with the work of Professor Vladimir Khavinson from the St. Petersburg Biogerontology Institute in Russia, will know how remarkable his work has been in the discovery of short-chain peptide bioregulators- that act as highly specific gene switches.

Now, four of these peptide bioregulators have been combined into topical skin preparations so that their performance can be bought to the field of aesthetic medicine; specifically the peptides in use are those from: • Cartilage • Blood vessels • Thymus gland • Pineal gland

What does each peptide provide for?

The beauty product line Youth Gems® contains the listed peptides and a ginseng extract called Neovitin®. They represent the very latest developed program of complex skin care designed for the face, neck, hands and the body. The line includes four unique active ingredients of short-chain peptides that have a directed tissue-specific action to improve all basic skin structures: • The thymus gland peptide stimulates tissue regeneration and the synthesis of tissuespecific proteins. Thus, cells proliferative and metabolic activity is enhancedaccelerating the renewal of various cell tissues. It also has an anti-inflammatory action, improving the healing time of wounds, as well as antioxidant, immune stimulating and antistress actions.

• The pineal gland peptide regulates metabolic processes and increases protein synthesis in skin cells. It also possesses potent antioxidant activity, normalizes the lipid peroxidation processes in skin cells that in turn promotes the elimination of negative

influences on the skin from external factors.

• The cartilaginous tissue peptide stimulates regeneration of fibroblasts and keratinocytes and interferes with the destructive changes in collagen skin structure; it also strengthens collagen structure of elastic skin fibers and increases elasticity.

• The vessel peptide regulates metabolic processes in the vascular wall, normalizes vascular tone and restores disturbed skin microcirculation. It strengthens and regulates the permeability of the vascular walls of skin vessels and improves skin turgor.

What else is included in Youth Gems® in addition to the four peptides?

In addition to the four peptides, the Youth Gems® also contain an incredible array of beneficial natural agents- which just by themselves would make other antiaging creams jealous! The range includes: Neovitin® (a complex isolated from ginseng), olive oil, raisin-seed oil, Argon oil, Soya oil, Jojoba oil, Bisabolol (extract from chamomile), Peony extract,

sodium hyaluronate (a derivative of hyaluronic acid), green tea extract, cocoa oil, carrageenan (from seaweed), winter bloom, almond extract and vitamin E.

What results have been seen?

Clinical trials and examinations have been conducted at the St. Petersburg Biogerontology Institute and they have concluded that these short chain peptides, when applied to skin cells, have many beneficial activities, shown below are some of those results. These include improved metabolism in vascular wall cells, the growth of new skin cells, enhanced antioxidant activity; increased blood flow circulation and greater moisturization.

The skin’s appearance becomes smoother, with fewer wrinkles and with more elasticity, all of which helps to lift the face contours producing a more radiant, youthful appearance. These beneficial effects were noted in 100% of women who took part in the voluntary clinical trial.

What’s available?

• Body milk: The body milk is a very light cream that can be applied to most areas of the body.

• Day cream: The day cream is the core product designed to be applied to the face and hands.

• Serum: The serum is designed to be used sparingly against the most noticeable skin aging effects on the face and neck.

• Tonic: This cleanser can be used to help any area become more firm and taught and may be splashed on as required.

All of the Youth Gems® should be applied onto clean, dry skinavoiding the eyes; makeup can be applied after absorption - if required.

Right: A 68 year old female before (left) and after (right) application of Youth Gems®

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31

SPOTLIGHT: BIOCUFF

™

MONITOR ING YOU R VA SCU L AR CONDITION The BioCUFF™ is a simple way of assessing both your blood pressure condition and your arterial flexibility; plus, you can use the BioCUFF™ in the comfort of your own home because you simply attach the device to your arm just like an ordinary blood pressure cuff.

What does the BioCUFF™ measure?

The BioCUFF™ provides a series of metabolic indicators that you can use to improve your lifestyle and so help to prevent the causes of cardiovascular disease.

We all know the risks of being overweight, of having high cholesterol or suffering from high blood pressure.

We also know how to reduce those risks – by exercising more, not smoking, reducing our alcohol intake and eating a balanced diet.

These include: • Diastolic blood pressure • Systolic blood pressure • The heart rate • Vascular condition – which linked to arterial flexibility.

Few of us know about the hidden dangers of arterial inflexibility, or how to measure it. This is where the BioCUFF™ is unique being as it is the first at-home

Above: The BioCUFF™ readout, showing both blood pressure, heart rate and vascular flexibility results.

32

device able of delivering this information to you within minutes.

What is arterial flexibility?

The BioCUFF™ works by evaluating your arterial flexibility, which experts say is one of the most important risk factors when it comes to assessing the likelihood of a heart attack or stroke.

Arteries are important because they’re responsible for blood flow around your body via your cardiovascular system. To work properly, it’s crucial that your arteries are kept healthy.

The poorer your vascular condition, the greater your chances of serious health issues

You may not recognise the heart failure symptoms as your arteries begin to stiffen Unfortunately arterial stiffness can occur without warning. Often there are no symptoms of cardiovascular disease and people don’t suspect they are in danger until they suffer an attack.

Figure 2 highlights that arterial stiffness is strongly correlated with mortality The BioCUFF™ provides a cardiovascular condition scale, shown by LED bars- that are either within the green zone (good), yellow zone (fair) or red zone (poor).

It is important to note that like blood pressure,

vascular condition should be monitored over time and not just taken as one reading.

The BioCUFF™ makes this simple by averaging your tests over time and therefore provides a more accurate result.

BioCUFF™ provides reassurance and a vital early warning system that helps you to be aware of changes and therefore keep your vascular condition in check.

Left: Arterial stiffness is a biomarker of aging, as shown here arterial stiffness tends to increase with age. Source: Millasseau et al., Clinical Science, 2002.

Our arteries usually stiffen with advancing age. This brings with it a greater risk of a potentially fatal heart attack, heart failure or stroke, as is shown in figure 1.

Left: Three groups (each approximately 80 persons) were monitored over 140 months for their survivability. Those in the flexible artery groups (marked as PWV <9.4 m/s and 9.4-12.0 m/s) survive best losing approx. 25%. But those in the hard artery group (marked as PWV >12.0 m/s) 90% of them die in the same period. Source: ESRD, Blacher et al. Journal of Circulation, 1999

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A-Z PRODUCT LIST OTHER INFO KEY: Not shipped to UK Not shipped to EU

Not shipped to Japan Not shipped to Australia (or New Zealand)

PRODUCT

CONTAINS

1ST LINE™ (OSCN, THIOCYANATE)

Not shipped to Canada

RETAIL PRICE

IAS PRICE

1 complete kit

$90

$79.99

5HTP (5HTP-PRO™)

90x 100mg capsules

$25

$22.49

ACARBOSE (GLUCOBAY®)

30x 100mg tablets

$30

$27.49

ACF228™

50 capsules

$60

$49.99

ACF228™ BREATHE-EASY

1 inhaler

$160

$149.99

ADRAFINIL (ADRA-PRO™)

40x 300mg capsules

$59

$49.99

ALDOSTERONE - NEW: ALDO-SPRAY™

5ml 10mg ear spray

$160

$149.99

ALDOSTERONE

15x 125 mcg capsules

$99

$94.99

AMINOGUANIDINE (AMINO-PRO™)

90x 75mg tablets

$29

$24.99

ANACERVIX (VINCAMINE + PIRACETAM)

30x 420mg capsules

$29

$24.99

ANASTROZOLE

28x 1mg tablets

$149

$139.99

ANASTROZOLE (ANASTRO-PRO™)

28x 100mcg capsules

$39

$34.99

ANDRO-PRO™

60 capsules

$55

$49.99

ANI-PRO™ (ANIRACETAM)

20x 750mg capsules

$35

$31.49

ATP (ADENOSINE TRIPHOSPHATE) ATP-BOOST™

60x 20mg tablets

$35

$29.99

B12 (VITAMIN B12) BEYOND B12®

40x 2mg sublingual tablets

$30

$29.99

B12 (VITAMIN B12) CROMATONBIC ®

8x 1mg i.m. ampoules

$20

$17.49

BCI (BEYOND CHELATION IMPROVED ®)

30 sachets

$80

$79.99

BEC5 CURADERM

®

20ml tube cream

$160

$144.99

BENFOTIAMINE (MILGAMMA MONO)

30x 50mg tablets

$25

$22.49

BEYOND CLEAN ® V2 (CALCIUM EDTA & ZEOLITE)

32 oz. bath salts

$60

$59.99

BEYOND FIBER®

504 grams powder

$50

$49.99

BHT (BUTYLHYDROXYTOLUENE) NEW: BHT-PRO™

120x 10mg capsules

$24

$21.49

BIO-CUFF™

one complete kit

$150

$149.99

BIO-CLIP ™ V2.00

one complete kit

$1500

$1249.99

BIO-EN’R-GY C ®

200 grams powder

$60

$59.99

BOLUOKE ® (LUMBROKINASE)

60 capsules

$108

$94.99

BONE-PRO2™

60 capsules

$35

$31.49

BROMOCRIPTINE (PARLODEL)

30x 2.5mg tablets

$29

$24.99

OTHER INFO

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33

PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

CABERGOLINE (DOSTINEX)

8x 0.5mg tablets

$80

$74.99

CAN-C™ (EYE-DROPS)

2x 5ml vials

$45

$39.99

CAN-C™ PLUS

90 capsules

$40

$34.99

CENTROPHENOXINE (CENTRO-PRO™)

60x 250mg

$29

$22.49

CEREBROLYSIN

5x 5ml i.m. ampoules

$95

$84.99

4x 20mg tablets

$85

$79.99

CIPROFLOXACIN (CIPROXIN)

10x 500mg tablets

$35

$32.49

COLCHICINE (COLCRYS )

40x 1mg tablets

$19

$17.49

COQ10 (COENZYME Q10) COQ10SR™ (SLOW RELEASE)

30x 100mg capsules

$30

$25.99

CURCUMIN (TURMERIC EXTRACT) CURCUMIN-SR™ (SLOW RELEASE)

30x 125mg capsules

$25

$22.49

D3 (VITAMIN D) D3-5000™

100x 5000 IU capsules

$19

$14.99

D3 (VITAMIN D) D3-PRO™

12x 50,000 IU capsules

$30

$24.99

DEPRENYL (SELEGILINE) JUMEX®

50x 5mg tablets

$65

$54.99

DEP-PRO™ (DEPRENYL/ SELEGILINE)

20ml/ 300mg bottle

$90

$84.99

DERCOS® SHAMPOO (AMINEXIL)

200ml bottle

$29

$22.49

DESMOPRESSIN (MINURIN ®)

2.5ml nasal spray

$39

$34.99

DIGESTIF™

60 capsules

$19

$14.99

DI-INDOLYMETHANE (DIM) DIM-PRO2™

100 capsules

$49

$44.99

DOXYCYCLINE

8x 100mg capsules

$29

$24.99

DR. GORDON’S ORGANIC BEST OF GREENS ®

10 oz. bottle powder

$32

$31.99

DUTASTERIDE (AVODART®)

30x 0.5mg tablets

$85

$79.99

ESNATRI™ (BIO-IDENTICAL ESTROGENS)

50ml 100mg cream

$55

$49.99

FINASTERIDE

28x 5mg tablets

$40

$37.49

FINASTERIDE (PROSCAR ®)

15x 5mg tablets

$45

$39.99

FLUCONAZOLE (DIFLUCAN ®) LOITIN ®

7x 50mg capsules

$39

$34.99

FLUDROCORTISONE (FLUDRO-PRO™)

100x 20mcg tablets

$24

$19.99

GABAPENTIN (NEURONTIN ®)

100x 300mg capsules

$49

$44.99

GABOB (GAMIBETAL®)

20x 500mg tablets

$39

$34.99

GALANTAMINE (REMINYL®) NEW: GALANTA-PRO™

90x 4mg capsules

$89

$79.99

GAMALATE B6 ®

60x 250mg tablets

$24

$19.99

GEROVITAL-H3 ®

5x 5ml ampoules

$59

$49.99

GEROVITAL-H3 ®

25x 100mg tablets

$35

$29.99

GH3-PRO™

60x 100mg tablets

$19

$14.99

GHRP2 NEW: GHRP2-PRO™

120ml 120mg liquid

$175

$159.99

GLUTATHIONE (ACG)

2 oz. spray

$45

$44.99

®

CIALIS ® (TADALAFIL)

®

34

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OTHER INFO

PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

HAIR-PRO™

2 oz. spray bottle

$180

$169.99

HRT PLUS ® (PUERARIA MIRIFICA)

60 tablets

$50

$49.99

HYALURONAN (HYALURONIC ACID) NEW: NOVISYN ®

30x 5ml liquid sachets

$30

$29.49

HYDERGINE ® (ERGOLOID MESYLATE) NEW: HY-PRO™

30x 4.5mg capsules

$45

$39.99

HYDROCORTISONE HYDRO-PRO ®

100x 5mg capsules

$35

$29.99

IDEBENONE (IDEB-PRO™)

60x 30mg tablets

$30

$24.99

INJECTION PACKS (INTRAMUSCULAR KIT)

30x pack

$30

$27.49

INJECTION PACKS (SUBCUTANEOUS KIT)

30x pack

$30

$27.49

LAETRILE (AMYGDALIN, VITAMIN B17) VITA-B17®

50ml 1% cream

$99

$89.99

L-CARNOSINE (CARNOSINE-PRO™)

60x 250mg capsules

$29

$24.99

LITHIUM (OROTATE) LITH-PRO™

100x 5mg capsules

$30

$24.99

L-TRYPTOPHAN (L-TRYP-PRO™)

50x 500mg capsules

$20

$17.49

MACA (LEPIDIUM MEYENII WALP) LONGEVITY MACA®

175 grams powder

$39

$38.99

MAGNESIUM NEW: MAGNESIUM-PRO™

2 oz. liquid 400mg

$13

$11.99

MELATONIN (MZS™)

60x 3mg tablets

$35

$31.20

MELATONIN NEW: MELA-SUB™

2 oz. liquid 90mg

$15

$11.49

OTHER INFO

NOTE: The UK can order melatonin in Pounds Sterling at: www.melatoninznse.com MEMANTINE (NAMENDA® ; EBIXA®) MEMANTINE-PRO™

42x 10mg capsules

$105

$89.99

METFORMIN (GLUCOPHAGE ®) METFORAL®

50x 500mg tablets

$25

$22.99

METFORMIN SR® (SLOW RELEASE)

56x 500mg tablets

$30

$27.99

MILNACIPRAN (SAVELLA®) IXEL®

56x 50mg tablets

$65

$59.99

MINERAL MOUTHWASH NEW: MIN-MOUTH™

16 oz. liquid bottle

$16

$14.99

MINSAW™ (MINOXIDIL +++)

30ml bottle topical liquid

$45

$39.99

MITO-PRO2™ NEW

75g powder

$49

$44.99

30x 150mg tablets

$29

$24.99

MOCLOBEMIDE (MANERIX ) MOCLAMINE ® ®

MODAFINIL - Please see www.modafinil-store.com for availability and pricing MSH (MELANOCYTE STIMULATING HORMONE) NEW: MSH2-PRO™

5ml 500IU nasal spray

$79

$69.99

NALTREXONE (NAVCOL®) NALTREX-PRO™

30x 4.5mg capsules

$70

$59.99

NEO40 DAILY®

30 lozenges

$60

$59.99

NEYDENT® TOOTHPASTE

50ml tube toothpaste

$18

$15.99

NADH NEW: COMING SOON!

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35

PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

NICERGOLINE (SERMION ®)

50x 10mg tablets

$50

$47.49

NITRIC OXIDE SALIVA TEST STRIPS (NEO40 ®)

10 saliva strips

$25

$24.99

NITRIC-PRO™

225 grams powder

$45

$39.49

NIZORAL

60ml bottle shampoo

$19

$14.99

OXYTOCIN (OXY-SUB™)

24x 20 IU sublingual troches

$85

$79.99

OXYTOCIN (OXY-PRO™)

5ml 500 IU nasal spray

$65

$59.99

PENICILLIN (PENILEVEL®)

30x 250mg sachets

$34

$29.99

PEO (PARENT ESSENTIAL OILS) NEW: PEO-PRO™

120 capsules

$44

$39.99

20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules

$85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $99 $85 $99 $85 $85 $85 $85 $85 $85

$74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $89.99 $74.99 $74.99 $74.99 $74.99 $74.99

PHENYTOIN (DILANTIN ®, EPANUTIN ®) PHEN-PRO™

30x 25mg capsules

$25

$19.99

PICAMILONE (PICAMILON-PRO™)

60x 50mg tablets

$25

$19.99

PIRACETAM (NOOTROPIL®)

20 grams 100ml liquid

$25

$21.49

PIRACETAM (NOOTROPIL®)

60x 800mg tablets

$30

$27.99

PIRACETAM (PIRA-PRO™)

100x 800mg tablets

$24

$17.99

POTASSIUM NEW: POTASSIUM-PRO™

2 oz. liquid 99mg bottle

$14

$12.99

PQQ (PYROLOQUINOLINE QUINONE) PQQ-PRO™

30x 20mg capsules

$44

$39.99

PULMOLIFE ® (FVC BIOLOGICAL AGE) PULMOLIFE ®

Spirometer + 4 tubes

$160

$139.99

PULMOLIFE ®

25 additional tubes

$25

$19.99

®

(2% KETOCONAZOLE)

OXALOACETATE COMING SOON!

PEPTIDE BIOREGULATORS (ALSO SEE YOUTH GEMS®) ADRENALS (GLANDOKORT®) BLADDER (CHITOMUR ®) NEW BLOOD VESSELS (VENTFORT®) BONE MARROW (BONOMARLOT®) NEW BRAIN (CERLUTEN ®) CARTILAGE (SIGUMIR ®) EYESIGHT (VISOLUTEN ®) HEART (CHELOHART®) NEW KIDNEYS (PIELOTAK®) LIVER (SVETINORM ®) LUNGS (TAXOREST®) NEW MUSCLE (GOTRATIX®) NEW OVARIES (ZHENOLUTEN ®) PANCREAS (SUPREFORT®) PINEAL (ENDOLUTEN ®) PROSTATE (LIBIDON ®) STOMACH (STAMAKORT®) NEW TESTES (TESTOLUTEN ®) THYMUS (VLADONIX®) THYROID (THYREOGEN ®)

36

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OTHER INFO

PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

PRAMIRACETAM (PRAM-PRO™)

40x 300mg tablets

$55

$49.99

PREGNENOLONE (PREG-PRO™)

50x 100mg capsules

$25

$22.49

PROGESTERONE (PREG-PRO™)

50ml 2.5 grams (5%) cream

$35

$29.99

PROPRANOLOL (INDERAL®)

30x 50mg tablets

$25

$19.99

PROSTATE-PRO2™

60 capsules

$35

$29.99

PYRIDOXAMINE (PYRIDOX-PRO™)

60x 50mg tablets

$35

$29.99

PYRITINOL (CERBON 6 ®)

60x 100mg tablets

$29

$24.99

RASAGILINE (AZILECT®) RASAGILINE-PRO™

30x 1mg capsules

$95

$89.99

REBOXETINE (DAVEDAX®) EDRONAX®

60x 4mg tablets

$70

$64.99

NEW: RELEASING-PRO™ (GHRP6)

5ml 500 IU nasal spray

$89

$79.99

RESVERATROL-SR™ (SLOW RELEASE)

30x 150mg capsules

$34

$29.99

RETIN-A® (RETIRIDES® 0.025%)

30ml cream

$39

$29.99

RETIN-A® (RETIRIDES® 0.050%)

30ml cream

$49

$39.99

RETIN-A® 0.100%

20ml micro-gel

$80

$74.99

ROXITHROMYCIN (RULID ®)

10x 50mg tablets

$35

$29.49

SAME (S-ADENOSYL-L-METHIONINE) SAMYR ®

20x 400mg

$69

$64.99

SELENIUM NEW: SELENIUM-PRO™

2 oz. liquid 300mcg

$17

$15.49

SERMORELIN (SERM-PRO ®)

30ml 30mg liquid

$225

$199.99

SILVER PROTEIN (ADVANCED CELLULAR SILVER 200 ®)

2 oz. spray

$35

$34.99

STABLON ® (TIANEPTINE)

60x 12.5mg tablets

$69

$62.49

SYMPROVE ® NEW

4x 500ml liquid bottles

$125

$124.99

TA65 ®

90 capsules

$600

$599.99

TAMANU

50ml bottle oil

$29

$24.99

TETRACYCLINE (AMBRAMICINA®)

16x 250mg tablets

$25

$22.49

THYMUS (THYM-UVOCAL®)

90x 200mg capsules

$110

$99.99

OTHER INFO

* Please note that this product has a shipping surcharge because of its weight.

THYROID - OUR NATURAL THYROIDS INCLUDE: ARMOUR ®

100x 15mg tablets 100x 30mg tablets 100x 60mg tablets 100x 90mg tablets 100x 120mg tablets

$79 $89 $99 $149 $169

$69.99 $79.99 $89.99 $129.99 $149.99

ERFA®

100x 30mg tablets 100x 60mg tablets 100x 125mg tablets

$59 $79 $99

$49.99 $69.99 $89.99

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37

PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

NATURE ®

100x 15mg tablets 100x 30mg tablets 100x 60mg tablets 100x 90mg tablets 100x 120mg tablets

$49 $55 $69 $79 $89

$39.99 $44.99 $59.99 $69.99 $79.99

EUTIROX® (T4)

100x 100mcg tablets

$34

$27.49

T3 NEW: T3-PRO™X

50x 20mcg tablets

$35

$29.99

TRH (THYROTROPIN RELEASING HORMONE) ABARIS™

20x 5mg sublingual tablets

$235

$209.99

VALDOXAN ® (AGOMELATINE)

28x 25mg tablets

$150

$144.99

VASOPRESSIN (VASO-PRO ®)

5 ml 500 IU nasalspray

$75

$69.99

VENLAFAXINE (EFEXOR ®)

28x 37.5mg tablets

$45

$39.99

VIAGRA® (SILDENAFIL)

4x 100mg tablets

$75

$69.99

VIELIGHT® (LASER)

633 inter-nasal laser

$300

$274.99

VINPOCETINE NEW: VIN-PRO™

120x 10mg capsules

$30

$27.49

VITAMIN C TEST STRIPS (VITACHECK-C ®)

50 strips

$18

$15.99

NEW: VOLT-PRO™ (ELECTROLYTES)

8 oz. liquid bottle

$22

$19.99

WOBENZYM-N ®

200 tablets

$75

$72.49

XANTHINOL NICOTINATE (XAN-PRO ®)

50x 150mg tablets

$24

$17.49

YOHIMBINE (PLAIN PROWESS )

100x 5mg tablets

$59

$49.99

NEW: YOUTH GEMS ® BODY MILK

200ml bottle

$50

$44.99

NEW: YOUTH GEMS ® DAY CREAM

50ml pump

$70

$64.99

NEW: YOUTH GEMS ® SERUM

30ml dropper

$90

$79.99

NEW: YOUTH GEMS ® TONIC

200ml bottle

$45

$39.99

ZEOLITE (ADVANCED CELLULAR ZEOLITE ®)

2 oz. spray

$45

$44.99

ZEOGOLD ENHANCED ® (ZEOLITE AND HYDROGEN)

50 grams powder

$65

$64.99

ZINC NEW: ZINC-PRO™

2 oz. liquid 50mg bottle

$13

$11.99

OTHER INFO

OUR SYNTHETIC THYROIDS INCLUDE:

®

DIDN’T FIND WHAT YOU WERE LOOKING FOR? PLEASE CONTACT US WITH YOUR REQUIREMENTS

38

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BOOK

PAGES

IAS PRICE

GREAT TEETH FOR LIFE

169 pages

$19.99

PASSION, SEX, LONGEVITY AND OXYTOCIN BY DR THIERRY HERTOGHE

159 pages

$49.99

THE PATIENT HORMONE HANDBOOK

310 pages

$224.99

THE (PHYSICIAN) HORMONE HANDBOOK V2 BY DR THIERRY HERTOGHE

833 pages

$449.99

THE PICTURE ATLAS OF ENDOCRINOLOGY BY DR THIERRY HERTOGHE

327 pages

$374.99

BY DR. BRIAN HALVORSEN

BY DR THIERRY HERTOGHE

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

Centrophenoxine The Smarter Way to Combat Mental Decline Centrophenoxine is a Nootropic or smart drug proven to increase brain power, improve longevity and create an overall sense of mental alertness.

CentroPro™

$24.99 each ($5.00 off) Centrophenoxine ‘cleans out’ Lipofuscin the build-up of plaques in the brain, heart, lung and skin cells that accumulates over a lifetime, improving their function and their longevity.

Pioneering Centrophenoxine researcher Imre Zs Nagy uses our Cent Pro, so if you want the experts choice you need our Centrophenoxine.

CONDITION CROSS-REFERENCE LIST This cross-reference list highlights individual products that have been used for these disorders.

Note: It does not mean that all these products are synergistic together.

Addison’s disease Aldosterone, peptide bioregulator (Glandokort®) ADHD (ADD, attention deficit disorder, see mental stimulants) Adrenal fatigue Aldosterone, Digestif®, hydrocortisone, peptide bioregulator (Glandokort®)

Blood disorders (see heart, arterial & blood) Blood pressure Neo40®, Nitric-Pro™, magnesium, oxytocin, potassium, propranolol, vinpocetine

Age Related Macular Degeneration (see eyesight)

Bone problems (also see joints & arthritis) Andro-Pro™, Bone-Pro2™, Esnatri™, Peptide Bioregulator (Bonomarlot®), progesterone, SAMe, thyroid

Age Related Mental Decline (see cognitive)

Breathing (see lungs)

AIDS (see HIV)

Allergies Bio-En’R-Gy C®, pregnenolone, thymus, Wobenzym®

Cancer (also see anti-oxidants & radiation) 1st Line™, anastrozole, artemisinin, BEC5® Curaderm, Bio-En’R-Gy C®, bromocriptine, CurcuminSR™, D3, DIM-Pro2™, HRT Plus®, laetrile, melatonin, metformin, naltrexone, oxaloacetate, progesterone, Resveratrol-Pro™, thymus, TRH, Wobenzym®

ALS (amyotrophic lateral sclerosis, see Lou Gehrig’s disease)

Cardiovascular (see heart & arterial disorders)

Alzheimer’s disease (see senile dementia)

Cataplexy (sudden fatigue) Adrafinil, modafinil, picamilone

Alcoholism (also see compulsive disorders) 5HTP, L-tryptophan, memantine

Anabolic (see growth hormone & testosterone) Anginas (see heart, arterial & blood) Animal use Can-C™ eye-drops, deprenyl, L-tryptophan, peptide bioregulators Antiaging (as impacting on a particular theory of aging) Calorie Restriction Carnosine, metformin, resveratrol Free radical ACF228™ Glycation Aminoguanidine Hayflick Carnosine, TA65® Membrane Centrophenoxine Mitochondrial Hydergine®, PQQ Neuroendocrine Metformin, TRH Rotational Melatonin Telomeres TA65® Anxiety (see stress) ARMD (see eyesight) Arterial (See heart, arterial & blood) Arthritis (rheumatoid & osteo) Andro-Pro™, Gerovital-H3®, Novisyn®, PEO pregnenolone, pyritinol, SAMe, thymus, Wobenzym® Asthma (see Allergies) Autism (also see chelation agents) Oxytocin, piracetam Back problems (see spine)

40

Bell’s palsy Beyond B12®

Cataract (also see eyesight) Can-C™, Can-C Plus™ Central Nervous System (CNS) Peptide bioregulator (Cerluten®) Cholesterol (see blood disorders) Crohn’s disease Naltrexone Chronic fatigue syndrome (see mental stimulants & physical energy improvement) Cognitive (also see memory & senile dementias) Alertness Adrafinil, modafinil Creativity Aniracetam, piracetam, pramiracetam Focus/concentration Deprenyl, desmopressin, vasopressin Energy ATP-Boost™, centrophenoxine, picamilone General support Gerovital-H3®, vinpocetine Intelligence Hydergine® Work load Hydergine®, thyroid Compulsive disorder treatment (also see alcoholism) 5HTP, Gamalate®, L-tryptophan, picamilone Cortisol alteration (also see stress) Aldosterone, DHEA, fludrocortisone, GABOB, Gamalate®, Gerovital-H3®, hydrocortisone, peptide bioregulator (Glandokort®), phenytoin Cross linking (see AGE)

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

Deep vein thrombosis (see frequent fliers)

Glaucoma (see eyesight)

Dental (see teeth & gums)

Glucose control (see diabetes)

Depression (also see well-being & anti-depressants) 5HTP, aniracetam, ATP-Boost™, CurcuminSR™, D3, deprenyl, Gerovital-H3®, lithium, L-tryptophan, milnacipran, picamilone, piracetam, pramiracetam, pregnenolone, SAMe, thymus, thyroid

Glycation prevention (see AGE)

DHT alternation (dihydrotestosterone) Dutasteride, finasteride, Hair-Pro™, MinSaw™, Nanogens®, peptide bioregulator (Libidon®), progesterone Diabetes Acarbose, aminoguanidine, ATP-Boost™, benfotiamine, L-carnosine, metformin, Nitric-Pro™, PEO, peptide bioregulator-(Suprefort®), pyridoxamine, TRH, thyroid Diabetes insipidus (see urination)

Gout Colchicine Growth hormone (improvement) Beyond GHS®, bromocriptine, deprenyl, GABOB, Gamalate®, GHRP2, GHRP6, hydergine, Neo40®, Nitric-Pro™, sermorelin, thymus, thyroid Hemorrhoids Nitric-Pro™ Hair improvement Dercos®, dutasteride, finasteride, Gerovital-H3®, Hair-Pro™, MinSaw™, Nitric-Pro™, Nizoral®, PEO Headaches (see migraines) Heath diagnostics (see at home test kits)

Dieting (see weight loss) Digestive issues Beyond Fiber®, Digestif®, Dr. Gordon’s organic greens®, peptide bioregulator (Stamakort®), Symprove® DNA support (also see telomeres) Carnosine, CoQ10, D3, PEO, peptide bioregulators, PQQ, resveratrol, TA65® Down’s syndrome Melatonin, piracetam Energy improvement (see physical energy & mental stimulants) Enzymes Boluoke®, Wobenzym® Epilepsy GABOB, Gamalate®, phenytoin Erectile dysfunction (also see sex-libido & premature ejaculation) Andro-Pro™, cabergoline, Cialis®, Neo40®, Nitric-Pro™, oxytocin, Viagra®, Vigor-Pro2™, yohimbine Eyesight ARMD MZS™ Cataracts Can-C™, Can-C™ Plus Contact lenses Can-C™ Dry eyes Can-C™ General support Aminoguanidine, peptide bioregulator (Visoluten®), vinpocetine Glaucoma Can-C™ Retinal MZS™, nicergoline, picamilone Retinal pigmentosa Picamilone, peptide bioregulator (Visoluten®)

Hearing disorders Aldosterone, Anacervix®, fludrocortisone, nicergoline, picamilone, vinpocetine Heart, arterial & blood (includes blood markers) Arteries (hard) Aminoguanidine, Bio-CLIP™, BioCUFF™, carnosine, resveratrol Blood pressure (high) Magnesium, Neo40®, Nitric-Pro™, potassium, Propranolol, vinpocetine Calcium Peptide bioregulator (Bobothyrk®) Cholesterol (high) Beyond B12®, Beyond Fiber™, CoQ10, Gerovital-H3®, TRH, Xan-Pro™ Dilation (nitric-oxide) Neo40®, Nitric-Pro™, Vielight® Fibrinogen CurcuminSR™, TRH, Wobenzym® General support CoQ10, PEO, peptide bioregulators (Chelohart® & Ventfort®), PQQ, vinpocetine, Wobenzym® Glucose (high) Acarbose, metformin, TRH Glycated end-products Aminoguanidine, metformin Heart pulse (irregular) ATP-Boost™, Bio En’R-Gy C®, thyroid Heavy metals (chelate) BCI®, Beyond Fiber®, Bio En’RGy C®, Homocysteine: Beyond B12®, BCI®, Bio En’R-Gy C®, TRH Lipofuscin Centrophenoxine Plaques (clots) Boluoke® Triglycerides Bio En’R-Gy C®, CurcuminSR™, PEO, TRH Hepatitis (see liver and infections)

Excitotoxins (reduction) Carnosine, deprenyl, idebenone, lithium, memantine

Herpes (also see anti-biotics) 1st Line™, ACF228™, BHT, silver protein, Wobenzym®

Fertility Melatonin, metformin, peptide bioregulator (Zhenoluten®), TRH

HIV (also see immune system improvement) 1st Line™, melatonin, naltrexone, thymus

Fibromyalgia (also see physical energy & mental stimulants & pain relief) 1st Line, milnacipran, naltrexone, oxytocin

HGH (see growth hormone)

Gastrointestinal (see digestive)

Homocysteine (see blood disorders) HRT (hormone replacement therapy for women) Esnatri™, HRT Plus®, melatonin, progesterone

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

41

Human growth hormone (see growth hormone) Hypertension (see blood pressure) Hypothyroidism Iodine, peptide bioregulator- thyroid (Thyreogen®), thyroids IBS (irritable bowel syndrome) Symprove® Immune system improvement (also see infections) 1st Line™, ATP-Boost™, Beyond B12®, carnosine, maca, melatonin, peptide bioregulator- thymus (Vladonix®), peptide bioregulator- thyroid (Thyreogen®), pyritinol, resveratrol, thymus, thyroid Infections (also see immune system improvement, anti-biotics & influenzas) 1st Line™, artemisinin, fluconazole, silver protein, Wobenzym® Inflammation (reduction) BCI®, Bio-En’R-Gy®, Boluoke®, CurcuminSR™, Digestif®, Dr. Gordon’s organic greens®, maca, PEO, pregnenolone, thymus, Wobenzym® Influenzas (also see anti-biotics, infections & immune system improvement) 1st Line™, Bio En’R-Gy C® Insulin & glucose control (see diabetes) Intestinal flora (see probiotics) Joints (also see bones & arthritis) Boluoke®, PEO, peptide bioregulator (Sigumir®), Novisyn®, pregnenolone, SAMe, thymus, Wobenzym® Kidney disorders (also see infections) Aminoguanidine, peptide bioregulator (Pielotak®) SAMe, TRH Learning (also see memory & mental stimulants) Aniracetam, desmopressin, Hydergine®, piracetam, pramiracetam, vasopressin

Memory (also see cognitive & senile dementia) General support PEO, picamilone, vinpocetine Imprinting (for later recall) Desmopressin, vasopressin Medium-long term Hydergine® Short term Aniracetam, piracetam, pramiracetam Speed of recall Centrophenoxine, pyritinol Methylation (conversion of one chemical into another inside the body) ATP-Boost™, Beyond B12® Bio-En’R-Gy®, Boluoke®, SAMe, Wobenzym®, Xan-Pro™ Migraines (also see pain relief) Beyond B12®, nicergoline, memantine, picamilone Mitochondrial support ATP-Boost™, CoQ10, deprenyl, glutathione, Hydergine®, idebenone, Mito-Pro2™ PQQ, pregnenolone, SAMe Multiple Sclerosis (also see mitochondrial support) Melatonin, naltrexone, TRH Nail condition Gerovital-H3®, PEO Narcolepsy (sleeping in the daytime) Adrafinil, melatonin, modafinil, picamilone Nitric Oxide release Nitric-Pro™, Neo40®, Nitric Oxide saliva test strips, Vielight® laser Oral health care (see teeth & gums) Osteoporosis (see bone problems)

Libido (see sex)

Pain relief ATP-Boost™, Gerovital-H3®, memantine, milnacipran, nicergoline, oxytocin, Wobenzym®

Lipids (see blood disorders)

Parasites (see infections)

Liver disorders (also see infections) CoQ10, Idebenone, peptide bioregulator (Svetinorm®), pregnenolone, SAMe, silver protein

Parkinson’s disease (see senile dementia)

Longevity enhancement (significant lifespan increases seen in animal studies) Centrophenoxine, deprenyl, melatonin, vasopressin

Photoaging (see skin problems)

Lou Gehrig’s disease (ALS) Naltrexone, TRH Lungs ACF228™ Breathe-Easy, centrophenoxine, glutathione, Nitric-Pro™, peptide bioregulator (Taxorest®), PulmoLife® Lupus Milnacipran, naltrexone Lyme’s 1st Line™, silver protein Macular degeneration (see ARMD & eyesight) Malaria (also see antibiotics) Artemisinin Menopause (see HRT)

42

Mental stimulants (also see physical stimulants) Adrafinil, aniracetam, centrophenoxine, deprenyl, desmopressin, modafinil, nicergoline, picamilone, piracetam, pramiracetam, vasopressin, Xan-Pro™

Pets (see animal use)

Ph balance (rebalancing) Dr. Gordon’s organic greens® Physical energy improvement (also see mental stimulants) ATP-Boost™, Beyond B12®, carnosine, CoQ10, idebenone, maca, Mito-Pro2™, NADH, oxaloacetate, PQQ, pregnenolone, SAMe, yohimbine PMS (pre-menstrual syndrome) Beyond B12®, HRT Plus®, maca, PEO, peptide bioregulator - Zhenoluten®, vinpocetine Premature ejaculation/ ejaculate (also see erectile dysfunction & sex-libido) Oxytocin Prostate (also see cancer) Beyond B12™, D3, DIM-Pro2™, dutasteride, finasteride, HRT Plus®, melatonin, peptide bioregulators – (Chitomur® & Libidon®), Prostate-Pro2™

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

Prolactin alteration Bromocriptine, cabergoline, GABOB, Gamalate® PSA (prostate specific antigen) (see prostate) Urination (frequent) Peptide bioregulator (Chitomur®), vasopressin

Stroke Anacervix®, aniracetam, Boluoke®, Hydergine®, idebenone, nicergoline, Nitric-Pro™, picamilone, piracetam, PQQ, pramiracetam, pregnenolone, vinpocetine Stomach (see digestive) Sunburn (see skin problems)

RNA (see DNA support) Senile dementia (also see cognitive & memory) Alzheimer’s Centrophenoxine, CurcuminSR™, galantamine, Hydergine®, memantine, nicergoline General support Anacervix®, aniracetam, PEO, piracetam, pramiracetam, vinpocetine, Wobenzym® Parkinson’s Bromocriptine, cabergoline, NADH, deprenyl, rasagiline Senility Gerovital-H3® Sex (libido, also see erectile dysfunction & premature ejaculation) Andro-Pro™, deprenyl, maca, MSH, oxytocin, yohimbine Skin problems (also see tanning)

Syndrome X (metabolic syndrome) Aminoguanidine, ATP-Boost™, melatonin, metformin, PEO Tanning (darkening the coloration of skin) MSH Teeth & gum disorders Doxycycline, Min-Mouth™ mouthwash, NeyDent® toothpaste, silver protein, zeolite Telomeres (also see DNA support) Carnosine, PEO, TA65® Testosterone & testes (also see fertility and prostate) Andro-Pro™, anastrozole, Beyond B12®, Beyond GHS®, DIM-Pro2™, melatonin, oxytocin, peptide bioregulator (Testoluten®), TRH, zinc Triglycerides (see blood disorders) Veterinarian (see animal use)

Age (liver) spots Centrophenoxine Anti-glycation Aminoguanidine, carnosine, Youth Gems® serum Anti-oxidant Youth Gems® day cream Cancer (non-melanoma) BEC5® Curaderm Cellulite Youth Gems® body milk Collagen Novisyn® Environmental Youth Gems® serum General support Beyond Clean2®, Gerovital-H3®, melatonin, PEO, thyroid Hyaluronic acid Novisyn® Infections Silver protein, thymus Moisturizer Youth Gems® day cream Scars/stretch marks Tamanu oil Sun spots BEC5® Curaderm Wounds HemaGel® Wrinkles Retin-A®

Weight gain (muscle mass) Andro-Pro™, Beyond GHS®, GABOB, GHRP6, sermorelin Weight loss (appetite suppressants and diet aids) 5HTP, acarbose, aminoguanidine, ATP-Boost™, benfotiamine, Beyond Fiber®, DIM-Pro2™, Dr. Gordon’s organic greens®, galantamine, GHRP2, L-tryptophan, metformin, Mito-Pro2™, MSH2, thyroid, TRH, Xan-Pro™ Well-being (also see depression) 5HTP, Active H-minus®, aniracetam, ATP-Boost™, Beyond B12®, deprenyl, Gamalate®, Gerovital-H3®, L-tryptophan, melatonin, Mito-Pro2™, PEO, picamilone, piracetam, pramiracetam, SAMe, thymus, thyroid, Wobenzym®, zeolite

Sleep disorders For less sleep adrafinil, ATP-Boost™, modafinil For more sleep 5HTP, gabapentin, L-tryptophan, melatonin Smoking cessation 5HTP Spine issues Peptide bioregulator (Sigumir®), Novisyn® Sports (see growth hormone, estrogen alteration, physical energy & testosterone) Stress (also see cortisol) 5HTP, GABOB, Gamalate®, Gerovital-H3®, maca, L-tryptophan, melatonin, oxytocin, picamilone, phenytoin, propranolol, pregnenolone

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

43

Defend Yourself Against Free Radical Damage With

ACF228

®

ME NO TH W YL W I FO TH LA TE

ACF 228® is a formula from Nobel Prize for medicine nominee Richard Lippman, Ph.D. ‘ACF’ stands for ‘Aging Control Formula’ and 228 is the number of versions it took to make this breakthrough. Dr Richard Lippman is a world authority on free radicals and peroxides and their effects upon longevity.

ACF228® has been double-blind clinically tested as described in US Patent Number 4,695,590.

ACF228® Dr Lippman’s 50 Caps $49.99

NEW: ACF228® Breathe Easy All the antioxidant power of ACF228® in a novel inhaler

IAS brings you ACF228® Breathe Easy which is a new type of inhaler that doesn’t contain steroids and can help with lung problems that cause excessive mucus and bronchial contractions.

ACF228® Breathe Easy 1 Tube $139.99

“73% of premature aging is caused by free-radical attack.” Dr Les Packard *Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

A-Z INGREDIENT LIST The following list is intended to highlight the key ingredients in some products and cross reference them to the most relevant product brand names.

Note: Those products with the same name as the ingredients are not shown here as they are within the A-Z product list.

If you want this-

look for:

Benzoic acid

Gerovital®

Acetyl-L-Carnitine (ALC)

ATP-Boost™

Beta blocker

Propranolol

Adaptogens

HRT Plus®, maca

Beta alistine

Adenosine triphosphate (ATP)

ATP-Boost™

Carnosine, ACF228®, Can-C™, Can-C Plus™

Beta glucan

BCI

AGE (advanced glycated end-product inhibitors)

ACF228™, aminoguanidine, Can-C™ Plus, carnosine, metformin, pyridoxamine

Betaine (TMG)

BCI, Bio-En’R-Gy®

Beta sitosterol

BCI

Aglomelatine

Valdoxan®

Beyond Any Multiple®

BAM

Alfalfa

Dr Gordon’s Organic Greens®

Beyond Chelation Improved®

BCI

Allicin (garlic)

BCI, EDD

bFGF

Hair-Pro™

Alpha lipoic acid (includes R-lipoic acid)

ATP-Boost™, BCI, Mito-Pro2™

BHT (butylhydroxytoluene)

ACF228™

Aminexil

Dercos®

Bioflavonoids

Wobenzym®

Amino acids (includes di-peptides)

5HTP, ACF228™, ATPBoost™, carnosine,

Bioperine

Bio-En’R-Gy®

Biotin

L-tryptophan, Mito-Pro2™, Nitric-Pro™

BCI, Beyond B12®, HRT Plus®, Nitric-Pro™

Blueberry extracts

Andro-Pro™

Aminohydroxybutyric acid (GABOB)

Gamalate®, Gamibetal®

Borate

Andro-Pro™, Can-C™

Aminosyn

Hair-Pro™

Boron

Andro-Pro™, BCI

Amygdalin

Laetrile

Bromelain

Digestif®, Wobenzym®

Anti-biotics

Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline

Buxamin (GABOB)

Gamalate®, Gamibetal®

Calcium

BCI, Bone-Pro2™, Nitric-Pro™

Carboxymethylcellulose

Can-C™

Anti-depressants

Lithium, milnacipran, moclobemide, reboxetine, Stablon®, Valdoxan®, venlafaxine

Catalase

ACF228™

Chelation agents

BCI, Beyond Fiber®, BioEn’R-Gy C®, centrophenoxine, Dr. Gordon’s organic greens®, carnosine, zeolite

Chlorella

Dr Gordon’s Organic Greens®

Anti-oxidants

See free radical scavengers

Arginine

Nitric-Pro™

Arimidex®

Anastrozole

Astragalus extracts

TA65®

Choline

BCI, centrophenoxine

Azilect®

Rasagiline

Chromium

BCI

Barley grass

Dr Gordon’s Organic Greens®

Chromium polynicotinate

ACF228™

Citrulline

Neo40®

Beating Cellular Impurities® BCI www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

45

Citrus bioflavonoids

BCI

Enzymes

Boluoke®, Wobenzym®

Co-dergocrine mesilate

Hydergine®

PEO-Pro™

Cod liver oil

BCI

EPA (eicosapentaenoic acid)

Coenzyme Q10

CoQ10, Mito-Pro2™

Ergoloid mesylate

Hydergine®, nicergoline

Copper

BCI

Essential Daily Defence®

EDD

Cortisol (cortisone)

Fludrocortisone, hydrocortisone

Cranberry extracts

Andro-Pro™

Creatine

Mito-Pro2™

Cresote bush

ACF228®, Digestif®

Cycloastragenol

TA65®

Cyclodextrin

CoQ10-SR™, Curcumin-SR™, resveratrol

Dehydroepiandrosterone

DHEA

Detox

BCI, Beyond Clean®, Beyond Fiber®, Bio-EnR-Gy C®, DIM-Pro2™, Dr. Gordon’s organic greens®, zeolite

DHA (docosahexaenoic acid)

PEO-Pro™

Diapid®

Vasopressin

Di-IndolylMethane (DIM)

ACF228™, DIM-Pro2™

DMAE (dimethylaminoeth- Centrophenoxine anol) DMSA (dimercaptosuccinic ACF228™ acid) DMSO (Dimethyl sulfoxide) Laetrile D-pantethine

Can-C Plus™

Dr. Dean’s recommended products

Acarbose, centrophenoxine, CurcuminSR™, Hydergine®, metformin, piracetam, Xan-Pro™

Dr. Gordon’s recommended products

46

BCI, Beyond B12®, Beyond Clean2®, Beyond Fiber®, Bio En’R-Gy C®, Dr Gordon’s Organic Greens®, HRT Plus®, maca, silver protein, zeolite

Dr. Pierpaoli’s recommended products

Melatonin, TRH

Dr. Wright’s recommended products

DHEA, Esnatri™, progesterone

Ebixa®

Memantine

Eldepryl®

Deprenyl

Electrolytes

Volt-Pro™

Estrogens (estradiol, estriol, Esnatri™ estrone) Evening primrose oil

BCI

Florinef®

Fludrocortisone

Folic acid (folate)

ACF228™, BCI, Beyond B12®; DIM-Pro2™, HRT Plus®, Nitric-Pro™

Free radical scavengers

ACF228™, ATP-Boost™, BioEn’R-Gy C®, glutathione, idebenone, melatonin, Mito-Pro2™, pyritinol

Fructoborate

Andro-Pro™

GABA (gamma-aminohydroxybutyric acid)

Gamalate®, picamilone

GABOB

Gamalate®, Gamibetal®

GHRP6

Releasing-Pro™

Ginkgo biloba

BCI

Glucophage®

Metformin

Glutathione

ACF228®

Glycerine (glycerin)

Can-C™

Glycosides

BEC5 Curaderm®

Grape seed extracts

BCI

Hawthorne Berry (crataegus)

BCI, Neo40®

HGH (human growth hormone/ somatropin)

GABOB, GHRP2, GHRP6, sermorelin

Hormones (includes Bio-identical: Aldosterone, hormonal support supple- Esnatri™, melatonin, MSH, ments) oxytocin, pregnenolone, progesterone, TRH

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

Natural (animal): Armour® thyroid, ERFA® thyroid, Nature® thyroid, thymus, vasopressin Synthetic: Desmopressin, Eutirox® thyroid, fludrocortisone, hydrocortisone, T3-Pro™

Supporting agents: Beyond B12®, DIM-Pro2™, GHRP2, GHRP6, peptide bioregulators, SAMe, sermorelin

Melanocyte stimulating hormone

MSH

Methione

BCI

Milk protein

Bone-Pro2™

Minerals (general)

Min-Mouth™ (mouthwash), Volt-Pro™

HRT (hormone replacement therapy for women)

DHEA, Esnatri™, HRT Plus®, melatonin, progesterone

Minoxidil

MinSaw™

Hyaluronic acid (hyaluronan)

Hair-Pro™, Novisyn®

Miroestrol

HRT Plus®

Hydrogen

ZeoGold Enhanced®

MSM (methylsulfonometh- Bio-En’R-Gy®, Nitric-Pro™ ane)

IGF-1 (insulin like growth factor one)

Hair-Pro™

N-acetylcarnosine

Can-C™

N-acetylcysteine

ACF228™, Can-C™ Plus

Indol-3-Carbinol (I3C)

DIM

Namenda®

Memantine

Injectable products

Cerebrolysin®, Cromatonbic® (B12), Gerovital®

Neurontin®

Gabapentin

Nettle root extract

Prostate-Pro2™

Inositol

BCI

Niacin (nicotinate, niacinamide, vitamin B3)

BCI, Nitric-Pro™, picamilone, Xan-Pro™

Inter-ear products

Aldo-Spray™ Desmopressin, MSH, oxytocin, GHRP6 (Releasing-Pro™), vasopressin, Vielight® laser

Nicotinamide adenine dinucleotide

NADH, PQQ

Inter-nasal products

Nootropil®/ Nootropyl®

Piracetam

Nordihydroguaiaretic acid (NDGA)

ACF228™, Digestif®

Oat grass

Dr Gordon’s Organic Greens®

Iodide/ Iodine

ACF228™, BCI, Iodine-Pro™

Isoflavonoids

HRT Plus®

Ixel®

Milnacipran

Omega 3 (DHA)

PEO-Pro™

Jerusalem artichoke

Beyond Fiber®

PEO-Pro™

Ketoconazole

Nizoral®

Omega 6 (linoleic acid, GLA)

L-arginine

Mito-Pro2™, Nitric-Pro™

Omega 9 (oleic acid)

PEO-Pro™

L-carnitine

Mito-Pro2™

Oxythiocynate (OCSN)

1st Line™

L-carnosine

Carnosine, ACF228®, Can-C™, Can-C Plus™

Parent Essential Oils (PEO)

PEO-Pro™ BCI, Gerovital®

L-citrulline

Neo40®

PABA (para-aminobenzoic acid)

L-histidine

Can-C Plus™

Palmitate

BCI

Lemon grass

Dr Gordon’s Organic Greens®

Pancreatin

Wobenzym®

Panthenol (pantothenic acid)

BCI, Mito-Pro2™

Papain

BCI, Wobenzym®

Peptides

Cerebrolysin®, GHRP2, GHRP6, peptide bioregulators, sermorelin, TRH, Youth Gems®

Pimagedine

Aminoguanidine

Prasterone

DHEA

Phosphatidylcholine

BCI

Licorice

Digestif®

Lipoic acid (includes R-lipoic acid)

ATP-Boost™, BCI, Mito-Pro2™

L-methione

ACF228™, Can-C Plus™

L-proline

Nitric-Pro™

Lucidril®

Centrophenoxine

Lumbrokinase

Boluoke®

Lysine

Nitric-Pro™

Magnesium

Andro-Pro™, BCI, BonePro2™, Digestif®, Gamalate®, Magnesium-Pro™, Mito-Pro2™, Nitric-Pro™

Phosphatidylserine

BCI

Phosphorous

Nitric-Pro™

Polyphenols

BCI

Malic acid

BCI

Pomegranate extracts

Andro-Pro™

Manganese

BCI, Mito-Pro2™

Potassium

BCI, Gerovital®,

Mastic

Digestif®

Potassium-Pro™

Meclofenoxane

Centrophenoxine www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

47

Pueraria mirifica

HRT Plus®

TMG (trimethylglycine)

BCI, Bio-En’R-Gy®

Probiotics

Beyond Fiber®, Digestif®, Dr. Gordon’s organic greens®, Symprove®

Tocotrienols (vitamin E)

BCI

Tribulus terrestris

Andro-Pro™

Trypsin

Wobenzym®

TRX

Hair-Pro™

Turmeric

Curcumin

VEGF

Hair-Pro™

Vincamine

Anacervix®

Procaine (Novocain®)

Gerovital®

Pygeum africanum

Prostate-Pro2™

Pyroloquinoline quinone

PQQ

Quercetin

Digestif®

Ubiquinol

CoQ10

Ubiquinone

CoQ10

Vitamin A (beta carotene, palmitate)

BCI

Red algae (carrageenan)

BCI

Vitamin B1 (thiamine)

Red clover herb extracts

Prostate-Pro2™

BCI, benfotiamine, Mito-Pro2™,

Red yeast

BCI

Nitric-Pro™

Reminyl®

Galantamine

Vitamin B2 (riboflavin)

BCI, Mito-Pro2™, Nitric-Pro™

Retinolic acid (tretinoin)

Retin-A®

Ribonucleic acids (RNA)

Cerebrolysin®, NeyDent® toothpaste

Vitamin B3 (niacin, niacinamide)

BCI, Mito-Pro2™, Nitric-Pro™, picamilone,

Ribose

Bio-En’R-Gy®

Xan-Pro™ Vitamin B5 (panthenol, pantothenic acid)

BCI, Nitric-Pro™

Vitamin B6 (pyridoxal, pyridoxine)

ACF228™, Andro-Pro™, Beyond B12®, BCI, DIM-Pro2™, Gamalate®; HRT Plus®, Nitric-Pro™, pyridoxamine (Pyridox-Pro™)

Rice bran husks

Beyond Fiber®

Rutin

Wobenzym®

Salicylic acid

BEC5 Curaderm®

S-Adenosyl-L-Methionine

SAMe

Saw palmetto (Serena Repens)

MinSaw™, Prostate-Pro2™ Vitamin B12 (cobalamin)

Selenium

ACF228™, BCI, DIM-Pro2™, MZS™,

B12, BCI, DIM-Pro2™, Neo40®

Vitamin B17

Laetrile

Prostate-Pro2™, Selenium-Pro™,

Vitamin D3 (cholecalciferol)

BCI, Bone-Pro2™, D3, Prostate-Pro2™

Thym-Uvocal®

Vitamin C (ascorbic acid)

BCI, Bio-En’R-Gy C®, Digestif®, MinSaw™, Neo40®, Nitric-Pro™

Vitamin E (tocopherols)

BCI, Can-C Plus™, DIMPro2™, Nitric-Pro™, Prostate-Pro2™

Vitamin K2 (menatretrenone)

BCI, Bone-Pro2™

Seligiline

Deprenyl

Shave grass

Dr Gordon’s Organic Greens®

Silicone/ Silica

BCI, Wobenzym®

Solasodine glycosides

BEC5 Curaderm®

Spirulina

Dr Gordon’s Organic Greens®

Water based

Symprove®

Stevia

Dr Gordon’s Organic Greens®

Wheat grass

Dr Gordon’s Organic Greens®

Sublingual products

Beyond B12™, oxytocin, sermorelin

Zeolite

Beyond Clean2®, ZeoGold Enhanced®

Thiocynates

1st Line™

Zinc

Thyroids

Natural brands: Armour®, ERFA®, West® (Nature®)

Andro-Pro™, BCI, Can-C Plus™, Mito-Pro2™, MZS™, Thym-Uvocal®, Zinc-Pro™

Synthetic brands: Eutirox® (T4), T3-Pro® (T3) Supporting agents: Peptide bioregulator (Thyreogen®) Thyrotropin releasing hormone

48

TRH

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

HyPro INTRODUCING:

™

Our new ergoloid mesylate formula replaces Novatis Hydergine® which is no longer manufactured.

Developed in the 1940s by celebrated Swiss chemist Albert Hofmann; the heart of Hydergine’s success lies in its ability to stimulate oxygen flow to the brain, which helps combat decline in mental capacity.

HyPro

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30 x 4.5mg capsules $39.99

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

TESTIMONIALS NICE COMMENTS FROM NICE PEOPLE

Dr. Aubrey De Grey “IAS has shown great vision and

Garry Gordon, MD, DO, MD (H)

Jonathan Wright, M.D.

“I am a 77 year old Physician

“Every adult has the right to take

Nicholas Perricone, M.D. “IAS is an outstanding resource

leadership, as an organisation

who has practiced medicine

care of his or her own personal

focused mainly on the

for nearly half a century.

health as he or she chooses.

date news and information

provision of contemporary

My antiaging research has

In the 20th and 21st centuries,

on healthy aging. They also

medical interventions against

permitted me to overcome

this universal human right

offer products of the highest

aging, and in also supporting

serious health problems.

has been nearly obliterated

integrity and efficacy. In fact,

the SENS Foundation’s efforts

Everyone can do this, but it

by an ocean of nanny-state

IAS is the world’s greatest

to hasten the development of

requires specialized knowledge

regulation and deliberate

source (often the only source)

much more powerful future

and the highest quality

suppression of information by

for the most cutting edge and

interventions.”

products. IAS is a vital link in

bureaucracies, with hidden

advanced nutrients to ensure

my antiaging program because

and not-so-hidden agendas.

optimum health span and

they continually provide both

International Antiaging

maximum life span.”

accurate information AND the

Systems is a beacon of useful

high quality products we all

health care information and

require, if we are to achieve

a literal island of freedom of

our maximum intended

health care product choice in

useful lifespan.”

our otherwise un-free health

for the finest, most up-to-

care world.”

Thierry Hertoghe, M.D.

“IAS is one of the pioneering societies in antiaging medicine...”

Thierry Hertoghe, M.D.

“IAS has a history of making throughout the world crucial, but difficultly accessible medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has

See all professional and public testimonials at: www.antiaging-systems.com/content/11-testimonials

50

www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

helped this new medical specialty move forward.”

PAYMENT OPTIONS ACROSS THE IA S WEBS ITES…

PAYMENT OPTIONS AND CONTACT DETAILS The IAS Group offers a wide range of payment options to make the completion of your order to be as easy as possible. For example, at www.antiaging-systems.com you can: 1.

2.

3.

4.

5.

6.

Pay by Visa or JCB credit-cards via UniChannel.

Pay by Visa using PayGate.

Pay by RedBaron vouchers - using your MasterCard or Visa credit-cards.

Use an electronic check via Check2Pay (US banks only).

Pay by Visa Debit Card (EU banks only).

Pay via Swift bank wire.

In addition, at www.antiaging-nutrition.com, www.iasjapan.com, www.antiaging-peptides.com and www.antiaging-nootropics.com you can use PayPal which also includes Visa, MasterCard, Debit Cards and American Express credit cards.

To discover more on how to use any of these payment methods please contact us, or visit this page for details: www.antiaging-systems.com/content/10-faqs

WEBSITES www.antiaging-systems.com (all of our products in one place; English language) www.antiaging-nutrition.com (our nutritional products; English language) www.antiaging-nootropics.com (our smart drugs and nutrients; English language) www.antiaging-peptides.com (our peptide bioregulators; English language) www.IASjapan.com (our nutritional products; Japanese language)

EMAIL ias@antiaging-systems.com (English language) iasjapan@antiaging-systems.com (Japanese language)

PHONE USA: 1-866-800-4677 (orders only) Japan: 050-553-29606 UK: 0208-123-2106 ROW: +44-208-123-2106

1-415-992-5563 (enquiries)

Please note: Our customer care team is available from 9am till 6pm GMT Monday-Friday.

Outside of these times your call will be handled by our out-of-hours answering service or go to voicemail.

MAIL Unfortunately personal checks and money orders cannot be accepted at this time.

Please contact our customer service team if you need any assistance in placing your order.

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

51

PEO Pro *Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

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PEO-Pro 120 Capsules $39.99 Special introductory offer save $5.00 per pack (Until 30th April 2015)