Aging Matters, Issue 3, 2015 by International Antiaging Systems (IAS)

No 3, 2015

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mTOR inhibitors in cancer, health and aging... Dr Marios Kyriazis covers this hot topic

PLUS: Vasopressin; a multi-talented hormone The power behind the pineal peptide Dr. Ward Dean answers your questions The in-house magazine for International Antiaging Society Group Private Club Members

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WELCOME Our lead is about the mTOR inhibitors; they have become a hot topic in antiaging medicine, ever since rapamycin was discovered in the soils of Easter Island (which explains the cover). So we invited Dr. Marios Kyriazis, one of Britain’s leading antiaging physicians to detail this subject for us. Dr Kyriazis (as his name indicates) also operates the ELPIs Foundation for Indefinite Lifespans in Cyprus, as well as the British Longevity Society, so as you can imagine he is a very well-informed person. There’s another nice piece from the Nobel-prize nominee Dr. Richard Lippman; we know a lot of you like his style. Here he reminds us of the benefits of the bioidentical hormone- vasopressin. Also included is an update about the remarkable peptide bioregulators; this one focuses on the pineal peptide- Epithalamin, which many consider to be the most remarkable of them all. Plus, Dr. Ward Dean answers your questions. Overall, we hope that you are finding our bi-monthly efforts informative, interesting and educational and that its quality may mean it adorns your coffee table! We always welcome your comments and suggestions.

INDE X WELCOME Phil says thanks for finding the time

FOREFRONT This month’s news

MTOR INHIBITORS IN HEALTH AND AGING Dr. Kyriazis details this topic

VASOPRESSIN, THE MULTI-TALENTED HORMONE Dr. Lippman describes its benefits

THE POWER OF THE PINEAL PEPTIDE More about the remarkable peptides

DR . WARD DEAN ANSWERS YOUR QUESTIONS One of our most popular features

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Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members (and therefore is not intended for the public). It focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the main focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual. Copyright 2015: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents. Disclaimer: All educational information is offered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. All prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice.

FOREFRONT THE THINGS YOU NEED TO K NOW FROM THI S MONTH’ S NE WS

A new class of anti-aging drugs discovered A brand new class of anti-aging drugs has been identified in a study from The Scripps Research Institute and the Mayo Clinic. So far the group have reported that the drugs, which the researchers have dubbed “senolytics,” have reduced frailty, improved heart function and extended the healthy lifespan of mice. Senolytics work by causing senescent cells to die, senescent cells are cells that have stopped dividing or have experienced DNA damage. These senescent cells include normal differentiated cells and stem cells. If left these cells secrete harmful substances that damage other cells, including stem cells, said study contributor Laura J. Niedernhofer, a Scripps Research scientist. Since senescent cells show some biochemical similarity to cancer cells, except for cell division, the researchers looked for cancer drugs that could selectively cause senescent cells to die.

So far the substances with these properties that have been identified are dasatinib, sold under the brand name Sprycel; and quercetin, the nutritional supplement with antihistamine and anti-inflammatory properties. Dasatinib killed senescent progenitor human fat cells, while quercetin was more effective against other cell types in humans and mice. Giving both drugs at the same time caused more senescent cells to die in cell cultures, and stronger anti-aging effects in the mice. Perhaps equally exciting is the fact that since these substances are already approved for human use, researchers say clinical trials should be relatively quick and easy to arrange. Now that this line of research has been identified the team are also confident that even stronger drugs may be discovered.

“If senolytic agents can indeed be brought into clinical application, they could be transformative,” the study stated. “With intermittent short treatments, it may

“With intermittent short treatments, it may eventually become feasible to delay, prevent, alleviate, or even reverse multiple chronic diseases and disabilities as a group, instead of one at a time.” 4

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eventually become feasible to delay, prevent, alleviate, or even reverse multiple chronic diseases and disabilities as a group, instead of one at a time.”

FOREFRONT Fluoride in drinking water linked to hypothyroidism A new study from England has found that fluoride added to drinking water is associated with a 30% higher rate of diagnosed hypothyroidism. The actual rate of under-active thyroid may be much higher since this study was only limited to people who were diagnosed. Many more may suffer with impaired thyroid function and not receive necessary treatment. In the study researchers looked at 2012 levels of

fluoride in the drinking water supply in England. About 10% of the English population or six million people live in areas with naturally or artificially fluoridated water containing 1 milligram of fluoride per liter of drinking water. They found that in areas with fluoride levels above 0.3 mg of fluoride per liter of water, rates of hypothyroidism were 30% higher.

Hypothyroidism or low thyroid function causes fatigue, weight gain, constipation, aches, dry skin, thinning hair, and intolerance to cold. It can also cause slowed heart rate, depression, and impaired memory. In addition to hypothyroidism, other studies have suggested fluoride has links to other serious health conditions such as heart disease, low IQs and cancer.

Garlic protects from more than just vampires Researchers from The University of Missouri have identified a nutrient in garlic which offers the brain protection against ageing and disease. They report it could even be used to prevent Alzheimer’s and Parkinson’s. The University of Missouri researchers found a carbohydrate celled FruArg is the key. ‘Garlic is one of the most

widely consumed dietary supplements,’ said Zezong Gu, associate professor of pathology and anatomical sciences at the MU School of Medicine and lead author of the study. ‘Most people think of it as a ‘superfood,’ because garlic’s sulfur-containing compounds are known as an excellent source of antioxidant and anti-inflammatory protection.

The team created a cell model of neurological stress and monitored microglial cell function, in order to study FruArg’s contribution to brain health. ‘When stress was applied to the model, there was an expected increase in microglial cells and their byproduct, nitric oxide,’ Gu said ‘However, once we applied FruArg, the

microglial cells adapted to the stress by reducing the amount of nitric oxide they produced. ‘This helps us understand how garlic benefits the brain by making it more resilient to the stress and inflammation associated with neurological diseases and aging.’

“...garlic benefits the brain by making it more resilient to the stress and inflammation associated with neurological diseases and aging.” www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

mTOR

inhibitors in cancer, health and aging By Marios Kyriazis, M.D.

When it comes to regulating aging, an important molecule which has widespread effects is mTOR. mTOR is the acronym for the Mechanistic (previously also called ‘mammalian’) Target of Rapamycin... Rapamycin (also known as sirolimus) is a protein kinase anti-fungal agent that was first discovered in the soils of Easter Island in the 1970s, which has been found to regulate the proliferation and development of cells, and to act as an immunosuppressant. It has been used to dampen the immune response following transplants. Rapamycin also has a positive effect on the heart and brain, particularly in age-related neurodegenerative diseases. mTOR acts as a central controller in signalling pathways which regulate the survival and function of the cell. It can affect cell division processes, the response to stress, and general cell and protein tasks. Figure 1: The impact of mTOR on various aspects of aging.

These signalling pathways are very complicated and depend on many feedback loops, energy supply, and a great variety of other molecules or signals. During certain diseases and aging, the function of mTOR can become deregulated and result in clinical manifestations, [see figure 1]. Despite talking about mTOR as if it is just one molecule, it functions, in fact, as two separate complexes called mTORC1 and mTORC2. (1) Several compounds have now been developed (or discovered) which inhibit some of the actions of mTOR and so improve certain health parameters. Rapamycin and its analogues inhibit the immune response by blocking the proliferation of T-cells and by reducing the impact of interleukin inflammato-

mTOR PATHWAY

TOR = target gene of rapamycin, antibiotic soil organism GROWTH FACTORS NUTRIENTS

CELLULAR STRESS

mTOR inhibitors Rapamycin*, resveratrol *Sirolimus FDAapproved drug

Cell Growth & Multiplication

New Blood Vessel Formation (Angiogenesis)

CELL SURVIVAL Transcription Initiation Factor

PROTEIN MAKING Digestion of Cellular Debris

Cell Metabolism

Stem cell Differentiation

Carcinogenic agents Dedifferentiation

Autophagy IKK-β/NF-KB

Differentiated cell

Dormant cell

DDR

Damaged cell

mTORC1 mTORC2 IIS

Senescent cell

Cell death Calorie restriction

Longevity

ry compounds. They also block the formation of new blood vessels (angiogenesis) which results in cancer cells being deprived of their blood supply. Other mTOR inhibitors have been developed, but most of these are based on the basic rapamycin molecular structure. For example, the rapamycin derivative temsirolimus is a soluble agent which has a reduced risk of side effects compared to rapamycin. Since it is water soluble, it can be administered by intravenous infusion. It is approved by the FDA for the treatment of kidney tumours. Other derivative molecules (called rapalogs, i.e. ‘rapamycin analogues’) are: • Everolimus (approved initially for the treatment of kidney tumours, and more recently for the treatment of breast and pancreatic tumours). • Ridaforolimus (also known as Deforolimus) is used for breast and other cancers.

Metformin Rapamycin Resveratrol Melatonin

Transformed cell

Cancer cell

Figure 2: Metformin, rapamycin and some other compounds with mTOR and insulin/IGF-1-like signalling (IIS)-inhibitory potential (resveratrol, melatonin, etc.) are able to modify both aging and carcinogenesis. Anisimov VN. Metformin and rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer. AGING, Vol 5, No 5 , pp 337-338.

These drugs bind to the same sites as rapamycin, and are considered to be generally better inhibitors. They can be used orally, as well as by intravenous injection. They work by stopping the growth of some cancers, but are not very effective in all cancers, particularly if used alone. One important mechanism of action of these rapalogs is through competition for the ATP molecule, thus blocking energy supply to tumour cells. Many rapalogs also interfere with apoptosis (loss of damaged cells). This results in increased apoptosis of cancer cells, thereby reducing the size of the tumour. These drugs inhibit both mTORC1 and mTORC2 elements, [see fig 2].

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Although initially promising, these rapalogs may be more effective if used in association with other tumour-suppressing agents. However, it remains unclear as to what specific tumours to use these agents on, because it all depends on what markers each tumour carries and how sensitive these markers are. Nevertheless, research is continuing at a quick pace. Apart from synthetic inhibitors of mTOR, there are certain natural ones. The following are some examples which are also used for their antiaging benefits and effects.

Epigallocatechin gallate: Also known as EGCG, this is a well-known natural compound (a component of green tea), with multiple benefits. It can disrupt the mTOR pathway and is effective in inducing apoptosis of human pancreatic cells in the laboratory.(2) The researchers stated: “Our results revealed that EGCG dramatically inhibited the proliferation of (pancreatic cancer) cells and induced apoptosis simultaneously. Furthermore, it upregulated (improved) mRNA and protein expression levels, as well as downregulated the expression of phospho-AKT and phospho-mTOR”.

Caffeine: Caffeine can induce apoptosis of cancer cells through modulation of the p53 element which takes active part in apoptosis. Caffeine can also

induce autophagy. This can be achieved through inhibition of the mTOR pathway, so a possible benefit associated with this is an anti-cancer activity.(3) In this regard, caffeine can be used in addition to chemotherapy in bone and soft tissue tumours. Caffeine affects mTOR and other protein kinases, and reduces inflammation markers.(4)

Curcumin: This ingredient of turmeric can be used with other established chemotherapy drugs in order to enhance their action, particularly in difficult-to-treat tumours such as glioblastoma in the brain. The mechanism is rooted in the ability of curcumin to block the mTOR pathway and thus enhance apoptosis of cancerous cells. (5) Curcumin down-regulates the mTOR signalling pathway, reduces the accumulation of beta-amyloid (the aggregate found in Alzheimer’s dementia) and thus improves cognitive function in mice. This effect is also due to curcumin’s ability to induce autophagy, i.e. degradation of abnormal protein accumulation. It can therefore be used as a neuroprotective agent during aging. (6)

Resveratrol: The case of resveratrol is particularly interesting. Resveratrol can inhibit certain cancers, and recent research has confirmed that one of the mechanisms involved is

mTOR inhibition, as well as modulation of apoptosis. The same mechanism may underlie resveratrol’s antiaging effects. (9) Resveratrol and rapamycin can enhance each other’s actions. At a very high dose, resveratrol can suppress aging through its mTOR inhibition mechanism alone. It is well known that apart from its effects on cancer, mTOR also has several effects on the aging process. (10) This may explain resveratrol’s multiple actions and benefits.

Other phytochemicals: All of the following have been found to inhibit the mTOR pathway: (7) timosaponin; genistein; diosgenin; gallic acid; and pomegranate. In a review paper published in 2011, it was reported that these compounds, through an inhibition of the mTOR pathway, enhance reprogramming of pluripotent stem cells. This shows that there are common pathways in cell regulation which can be affected by modulation of mTOR and can eventually affect aging itself. (8) Several experiments in mice and other animals have shown that the mTOR molecule can affect both the average and maximum lifespan. (11) [See figure 3].

Oxaloacetate - a most promising compound Oxaloacetate is an organic compound which takes part in several metabolic processes such as synthesis of amino acids and fatty acids; it also regulates mitochondrial and brain function. Among its other benefits, it is an antioxidant, brain function-enhancer, and a modulator of certain age-related genes such as FOXO. Plus, oxaloacetate is also an effective mTOR modulator. In fact, oxaloacetate may also be considered to be an mTOR mimetic, which means that it has benefits similar to other mTOR inhibitors (such as modulation of apoptosis and reduction of glutamate).

The Mice That Roared

Rapamycin has been shown to extend the lives of both healthy and cancer stricken mice Mice with cancer

Percent of mice still alive over time 100%

75%

Figure 3: Gifford, B. Did a Canadian medical expedition lead to the discovery of an antiaging pill? Bloomberg News, February 12, 2015.

As mentioned above, agents such as rapamycin work by improving signalling between the cells. An example of these pathways is the regulation of the Growth Hormone/insulin/IGF-1 pathway, inactivation of which has been shown to increase lifespan in the laboratory. (12) In a systematic review of the top 10 antiaging interventions being studied today, mTOR interventions were classed second in importance, with calorie restriction being first, and nutrients such as resveratrol being third. (13) [See figure 4].

50%

No rapamycin

Treatment starts

Normal mice

Treatment starts

With rapamycin

25%

0% 0 days

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1,300 days

Dietary Restriction NUTRIENTS (AMINO ACIDS)

GROWTH FACTORS

mTOR

ATP

/ADP

Rapamycin

NUCLEUS

Growth & Reproduction

However, it has additional benefits that originate from mechanisms other than mTOR inhibition. (14) Oxaloacetate is a wellknown calorie restriction mimetic, and can even be considered as an exercise-mimetic [Ed. - we have asked Dr. Kyriazis to write about exercise mimetics for a future issue of the Aging Matters™ magazine]. This is because it can help increase production of energy and improve muscle endurance. Supplementation with oxaloacetate increases lifespan in C. elegans worms. This is dependent on the transcription factor FOXO, as mentioned above, but also on protein kinases which depend

Increased Lifespan

on adenosine monophosphate (AMP)--which is involved in energy production. (15) Perhaps an interesting situation here is to realize that mechanisms for aging regulation, energy production and mTOR regulation are all interdependent, and one compound may have multiple effects across many regulatory pathways. Carnosine was another good example of this--but now research supports oxaloacetate as another pluripotent agent.

Summary It is clear that aging is very dependent upon mTOR-regulated pathways and processes, and that several agents acting on these pathways have direct

Figure 5: The impact of mTORC1 on the diseases of aging. Johnson SC, Rabinovitch PS, & Kaeberlein M. mTOR is a key modulator of aging and age-related disease. Nature (17 January 2013), 493,338–345

Alzheimer’s disease Cancer

Cognitive decline

Immune system decline

Kidney disease

AGEING

Type 2 diabetes

Heart disease

Autoimmune disease

Figure 4: How rapamycin can mimic the effects of dietary restriction. Research explains action of drug that may slow aging and related disease. OSU News & Research Communications 20 May 2014

or indirect benefits. Several pathways involved in cancer can be regulated by mTOR inhibitors, and many of these pathways are also involved in aging. It is logical to assume that mTOR inhibitors have a positive benefit on aging. Some antiaging physicians

and scientists are recommending the more natural molecules involved in mTOR inhibition (such as resveratrol, oxaloacetate or curcumin) be added to our anti-aging regimens as a way of addressing age-related health problems.

References 1. Zhou H et al. Updates of mTOR inhibitors. Anticancer Agents Med Chem. 2010 Sep;10(7):571-81 2. Liu S et al. PI3K/AKT/mTOR signaling is involved in (-)-epigallocatechin-3-gallate-induced apoptosis of human pancreatic carcinoma cells. Am J Chin Med. 2013;41(3):629-42 3. Saiki S et al. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/ p70S6K inhibition. Autophagy. 2011 Feb;7(2):176-87 4. Miwa S et al. Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways. Anticancer Res. 2012 Sep;32(9):3643-9 5. Yin H et al. Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mTOR signaling. Oncol Rep. 2014 Oct;32(4):1610-6 6. Wang C et al. Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice. Eur J Pharmacol. 2014 Oct 5;740:312-20 7. Tan HK et al. The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals. Asian Pac J Cancer Prev. 2014;15(16):6463-75 8. Chen T et al. Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell. 2011 Oct;10(5):908-11

9. Sui T et al. Resveratrol inhibits the phosphatidylinositide 3-kinase/ protein kinase B/mammalian target of rapamycin signaling pathway in the human chronic myeloid leukemia K562 cell line. Oncol Lett. 2014 Jun;7(6):2093-2098 10. Johnson SC et al. Modulating mTOR in Aging and Health. Interdiscip Top Gerontol. 2015;40:107-27 11. Lamming DW et al. Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest. 2013 Mar 1;123(3):980-9 12. Anisimov VN. Conservative Growth Hormone/IGF-1 and mTOR Signaling Pathways as a Target for Aging and Cancer Prevention: Do We Really Have an Antiaging Drug? Interdiscip Top Gerontol. 2015;40:177-88 13. Allison DB et al. Aging and energetics’ ‘Top 40’ future research opportunities 2010-2013 [v1; ref status: indexed, http://f1000r.es/4ae] F1000Research 2014, 3:219 (doi: 10.12688/f1000research.5212.1) 14. Wilkins et al. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum Mol Genet. 2014 Dec 15;23(24):6528-41. 15. Williams DS et al. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell. 2009 December; 8(6): 765–768.

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VA S O P R E S S I N a multi-talented hormone

By Dr. Richard Lippman Mark had a medical problem, which he embarrassingly referred to as a ‘senior slump,’ but he refused to visit a doctor because he considered them to be quacks. Thus, he continued to suffer poor erections despite self-dosing with copious amounts of Viagra® and Cialis. Eventually, Mark’s wife convinced him to see me and I meticulously questioned and examined him. Mark’s blood pressure was low and he was dehydrated. He urinated frequently at night. I eventually learned that Mark suffered a three centimeter laceration of a finger due to an accident with a power mower, and unexpectedly bled profusely from what appeared to be a minor

injury. His blood simply would not coagulate. Mark was often thirsty at night, and felt compelled to urinate frequently. Worse still, he had memory problems and complained about not ‘thinking straight’ anymore. In my office, his blood pressure (BP) measured 95 over 60—which is fine for a highly trained athlete, but a bit low for a deconditioned 47 year-old man. Along with low BP, he

felt that he had lost energy compared to his younger self.

Antiaging medicine to the rescue Both vasopressin (ADH) and oxytocin are hormones made in parvoventricular and supraoptic nuclei cells in the hypothalamus, a small gland located in the brain (Fig. 1). Both hormones are transported inside axons, long nerve

endings of the neurons, to the posterior lobe of the pituitary gland where they are secreted into the bloodstream. (1) Vasopressin is essential for maintaining normal blood pressure, and insuring a sufficient amount of blood in an erect penis or an aroused clitoris. In his aging body, Mark appeared to be deficient in vasopressin as well as other hormones such as thyroid and oxytocin. I reasoned

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that he was probably lacking oxytocin since the same cells in the hypothalamus produce both vasopressin and oxytocin, and a deficiency of one usually means a deficiency of the other. My meticulous examination revealed the following signs and symptoms of hypothyroidism: loss of the outer third of the eyebrow; swollen eyelids; dry, thick, brittle hair; swollen lips and tongue; dry, rough skin; cold hands and feet; excessive laxity of the fingers; brittle, slow-growing nails; constipation and abdominal bloating; thick, swollen calves and especially ankles; sluggish and slow thinking and moving; attention deficit; bradycardia and faint heart sounds; and slow Achilles tendon reflexes (2). I recommended that Mark start consuming 30 mg Armour® thyroid every morning without any caffeine. According to Dr. Thierry Hertoghe, caffeine interferes with Armour’s action (3). I further recommended that he add 10 units (one spray each) of vasopressin (Vaso-Pro™) and one 10 IU spray of oxytocin (Oxy-Pro™) at bedtime. I referred Mark to a well-known urologist for a digital rectal exam in order to ascertain if Mark’s frequent bathroom visits might be caused by BPH (benign prostate hyperplasia or enlarged prostate gland). BPH is an all-too-common problem in older men who produce

excessive amounts of the essentially female hormone estradiol, without balancing it with natural progesterone (Progesterone-Pro™). His urologist reported that Mark’s prostate was slightly enlarged but shouldn’t cause problems for many years to come. Thus, Mark began consuming three vital and deficient hormones (Armour®, vasopressin and oxytocin) daily.

Supra-Optic Nucleus

Paraventricular Nucleus Hypothalamohypophyseal Tract

Optic Chiasma

Interior Hypophyseal Artery Vasopressin Oxytocin

Figure 1 The hypothalamus showing where the release of oxytocin and vasopressin takes place

Two months later there is energy and sparkle Two months after our original meeting, Mark entered my office with energy in his step and a sparkle in his eye. He was no longer bothered by his former symptoms, and he offered me his profound thanks. I thanked him in return for being such a good patient.

Aftermath Most middle-aged or older people should maintain their aging bodies just as they maintain their aging cars. This was certainly the case with Mark, who only needed a little confidence in a competent antiaging-trained physician, who could readily diagnose a patient and arrive at needed remedies. In addition to the vasopressin and oxytocin, high on the list of needed remedies

was Armour® thyroid, which is lacking in many older people --especially women-- for reasons unknown. Thyroid has long been known to be deficient in aging populations. According to a 1957 article in the Journal of the American Medical Association, 40% of American women living in the Mid-West have ongoing and undiagnosed thyroid deficiencies. (4) Unfortunately, conventional medical doctors rely entirely on thyroid blood tests, overlooking the hypothyroid signs and symptoms presented by their patients. One should not rely on what I believe are erroneous laboratory reference values for thyroid hormone blood levels, and fail to treat many card-carrying hypothyroid patients. Another little-used remedy is to employ the Russian thyroid bio-peptides,

which can often reactivate failing thyroids.

Other benefits of vasopressin Vasopressin has other benefits when supplemented. Patients can now reverse aging of their faces and hands by having their dermatologist apply DermaPen™ therapy. (5) This therapy is a type of mesotherapy, which has been employed in Europe for many years. It literally turns back the clock on patients’ faces and hands with the help of vasopressin (Vaso-Pro™) and other hormones. In the skin on one’s hands and face, vasopressin (Vaso-Pro™) prevents dehydration, which is responsible in part for fine lines and wrinkles. Before employing the Dermapen™, a dermatologist

“Two months after our original meeting, Mark entered my office with energy in his step and a sparkle in his eye. He was no longer bothered by his former symptoms, and he offered me his profound thanks.” 12

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applies a numbing cream (lidocaine) to the face and hands and waits an hour. Then, the physician will move a DermaPen™ pen over the surface of the skin. This electric pen contains 40 or 50 tiny needles that are often adjusted to penetrate the skin to a depth of 0.50 mm. On sensitive tissues such as the forehead and eyelids, the depth of the needles is set to only 0.25 millimeters. This pen punctures and opens the skin down to the dermal layers and allows improved blood flow to underlying tissues. During this process, slight bleeding and shortterm inflammation will occur. The body’s own stem cells are attracted to the site of injury, which, in turn, encourages new collagen growth. To encourage the good formation of collagen, vitamin C cream and hormones such as vasopressin and sex hormones should be applied to the pen-treated areas immediately after, according to hormone expert Dr. Thierry Hertoghe. (3) After a half dozen or more treatments spaced at least four weeks apart, the face and hands become plumper and softer due to better collagen production. If you look at the back of a 70-year-old’s hand, you will notice that the collagen filling material has nearly vanished. This effect is due to aging-- and by-andlarge, only tendons remain with unsightly blue veins running across the surface of the tendons. Also, the lack of collagen filling material leaves the skin of the hands and sometimes the face translucent and pale. These are the signs of advanced aging we all face if we

“Some people walk along their path in life and stumble upon the truth. Then, they pick themselves up, dust themselves off, and proceed on their way as if nothing had happened!” - Sir Winston Churchill When I questioned promi- technician hooked me up nent English doctors practicwith electrodes on my chest, ing in London, few of them and I ran for five minutes on appreciated Dr. Hertoghe’s a treadmill and rested for five more minutes. My resting Dr. Hertoghe explains the approach. This reminds me advantages of vasopressin of what Winston Churchill BP was 128 over 73, which said about people not open indicated that I was ‘youngto accepting new knowledge: at-heart’ and capable of heavy Dr. Thierry Hertoghe, head “Some people walk along their aerobic exercise. All of my of the Hertoghe School of path in life and stumble upon values were so exceptional Medicine, recently spoke in the truth. Then, they pick that the cardiotech asked me London, England (3) about themselves up, dust themif a mistake had been made the advantages of suppleselves off, and proceed on when I wrote down that I was mental vasopressin. He said their way as if nothing had 70 years old. He said that I that vasopressin (Vaso-Pro™) scored like a person twenty or would improve kidney health. happened!” On the other hand, many thirty years younger. He stated emphatically that American physicians have signs and symptoms of a taken Dr. Hertoghe far more vasopressin deficiency are seriously. I have used many deep and sunken eyes, sharp of his recommendations. wrinkles, soft eyeballs, poor Consequently, I can confimemory and dehydration Figure 2 dently state that he has not folds on the upper eyelids. In A dermal pen being applied to exaggerated. For example, I his practice in Belgium, he the face have checked my progress in recommends vasopressin to reversing my aging by doing improve sleep by approxinumerous medical tests mately 45 minutes per night. during the last four years. He stated that vasopressin Recently, I took a stress-EKG (Vaso-Pro™) combined with test at the local hospital’s oxytocin (Oxy-Pro™) is often cardiology department. A an effective treatment for schizophrenia. In reference to aging, Dr. Hertoghe claims that vasopressin will increase one’s References chance of survival by a factor of four. He also advised that a 1. Hertoghe, T. 2012, Passion, Sex, and Long Life, International Medlack of vasopressin might be a ical Books, www.imbooks.info. , p. 18. cause of short-term memory 2. Hertoghe, T. 2010, The Hormone Handbook, Vol. 2, International loss and low electrolytes, such Medical Books, Luxemburg, p. 127. as sodium. Another cause 3. Hertoghe, T. Oct. 2014, Anti-Ageing Conference, AACL 2014, Lonmay be lack of dopamine don, United Kingdom. (which can be improved with 4. Jackson, A. S. Hypothyroidism, JAMA, Sept. 1957, 165(2), pp. 121-124. deprenyl). do not accept and take advantage of the latest techniques in antiaging medicine.

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The Power of the Pineal Peptide By Leslie J. Farer

Back in the 1980’s, a colonel in the Soviet army Medical Corps was assigned a seemingly impossible, though intriguing task: to come up with a way to protect troops against the risks of modern military weapons, (such as a blinding battlefield laser or radiation exposure) while at the same time regenerate damaged organs and tissues in the event of injury. What he discovered, through experiments supported by the generous funding of the Soviet military, was that certain naturally-produced substances, later termed ‘peptide bioregulators,’ (that were isolated from various animal tissues and organs), have the capacity to act at the genetic level to regenerate tissue and restore the function of the corresponding organ(s) in other animals or in humans. As a byproduct of their rejuvenating properties, these biologically active short chains of amino acids were also discovered to act as so-called ‘geroprotectors’ (therapeutics that target the root causes of aging and age-related diseases), with impressive longevity-promoting potential. Once a military secret in the 1980’s, a wealth of subsequently-published research has demonstrated that peptide bioregulators restore physiological balance, prevent age-related diseases, increase life span and more. One in particular, the pineal bioregulator peptide called Epithalamin, is considered to be the most promising in its class of geroprotectors.

Let’s first examine the properties and actions of peptide bioregulators in general, and then the particular benefits of pineal peptide Epithalamin, in stemming the onset of aging and age-related diseases. EACH PEPTIDE RESTORES THE FUNCTION OF A SPECIFIC ORGAN In the early days of his research, the then Soviet colonel, Dr. Vladimir Khavinson, (who is currently the president of the International Association of Gerontology and Geriatrics and Head of the St. Petersburg Institute of Bioregulation Professor Vladimir and Gerontology), developed Khavinson a method for the isolation, purification and fractionation of low-molecular-weight peptides from extracts of different bovine-sourced organs and tissues such as the pineal gland, thymus, hypothalamus, retina, endocrine glands and liver etc. These amino-acid chains are endogenously produced in the cells of healthy tissues and play a regulatory role, from the molecular and cellular levels to the overall biochemical and physiological functioning of the particular organ in which they are manufactured (hence, the designation ‘peptide bioregulator’). Professor Khavinson analyzed over 15,000 genes

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in mouse heart and brain tissue before and after the injection of various peptide extracts, (including the pineal peptide Epithalamin) and identified the mechanism of ‘peptide regulation of genetic activity’ whereby each peptide interacts with DNA, transferring information encoded in its amino acid sequence to regulate particular genes in a particular tissue. (1,2)

were shown to trigger protein synthesis and restore even the function of aging, deteriorating organs in old animals! (1) - It’s a glimpse into the peptide bioregulator antiaging potential. [Ed. – Please see the major feature on these peptide bioregulators in issue 2, 2013 of the Aging Matters™ magazine for more details].

“Trials using peptide preparations obtained from other organs (i.e. prostate, cerebral cortex, adrenal gland, liver, etc.) have all demonstrated beneficial effects as evidenced by improvements in the condition of the respective organ.” Activation of these genes stimulates protein synthesis, (1,3,4) and the manufacture of proteins according to the encoded genetic information, (a crucial physiological process which we’ll examine further below). Short-chain peptides also have the capacity to induce cell proliferation and differentiation, (1,2,4) resulting in tissue repair and restoration of organ function. When Professor Khavinson administered peptide extracts to animals (and later humans), he found that they did indeed stimulate protein synthesis and produced regenerative effects in cells and tissues of the organ from which the particular peptide had originally been derived. (2) For example, retinal peptides (example, Visoluten®) initiate the formation of retinal and pigment cells in patients with retinal degeneration, (1,2) thymic peptides stimulate immunity, (1,5) and pineal peptides induce the aging pineal gland to manufacture melatonin. (1,5)

PEPTIDES INTERACT WITH GENES’ DNA TO ACTIVATE PROTEIN SYNTHESIS

The molecular model Professor Khavinson proposed, which was later demonstrated experimentally, involves ‘complementary binding’ or complexing of the amino acid sequence of a shortchain peptide with the nucleotide sequence on a gene’s DNA. (1,6,7) DNA is a long polymer chain composed of repeating units called nucleotides which, by their combination of nitrogen bases, create a ‘code’ or blueprint for the manufacture of proteins; each ‘code’ is specific for one of thousands of different proteins. The formation of the peptide-DNA complex causes a weakening of bonds holding together the DNA double helix and stimulates the splitting of the two strands, (1,6) a precursor necessary for gene transcription, (the conversion of the gene’s ‘code’ into protein-synthetic information) that ultimately results in the manufacture of a protein, Trials using peptide preparations obtained from (see Figure 1). other organs (i.e., prostate, cerebral cortex, adre- Protein synthesis is a complex manufacturing pronal gland, liver, etc.) have all demonstrated bene- cess indispensable to life, producing such crucial ficial effects as evidenced by improvements in the substances as enzymes, structural proteins such condition of the respective organ. (5) Amazingly, as collagen and hormones- such as insulin, antipeptides isolated from organs of young animals bodies and hemoglobin. We’ll see below specific

Figure 1: The local separation of strands due to the peptide Epithalon® (Ala-Glu-Asp-Gly) binding in DNA double helix. Peptide bioregulators act as gene switches triggering protein synthesis.

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examples of the ability of the pineal peptide- Epithalamin to ‘switch on’ genes to synthesize these essential substances to provide overall restorative effects. COUNTERING PEPTIDE DEFICIENCIES ASSOCIATED WITH AGING In a nutshell, the main point to digest here is that these biologically-active peptides act at the genetic level and possess the ability to recover functions of tissues and organs undergoing age-related deterioration. Aging is characterized by a peptide-dependent downward spiral: changes in gene expression accompanied by decreased endogenous peptide production lead to disorders in protein synthesis, in turn causing structural and functional deterioration of various organs (pineal gland, liver, pancreas, thymus, retina, nervous, immune and endocrine systems) that result in aging, and age-related diseases. (1,2,4,5,6,8) Thankfully, this negative cascade can be ameliorated, or even reversed, through the delivery of the appropriate peptide(s) which have been shown to exhibit geroprotective, or antiaging properties. (Professor Khavinson refers to the process of peptide administration to

animals or humans the ‘epigenetic regulation of aging.’ (6) STUDIES ON THE PINEAL PEPTIDE SHOW MULTIFACETED REGENERATIVE EFFECTS In the late 1990’s Professor Khavinson began manufacturing bioregulators synthetically, based upon the amino acid composition of peptide extracts isolated from animal tissues. These laboratory-formulated peptides, consisting of two to four amino acids, were shown to possess equivalent biological activity and safety to the animal-derived extracts. (1-3) Epithalamin is expressed as Epithalon®, a synthetic tetrapeptide- Ala-Glu-AspGly (alanine-glutamic acid-aspartic acid-glycine), modeled on the amino acid sequence of Epithalamin, a polypeptide complex isolated from the bovine pineal gland and also as Endoluten®, (see figure 2 for explanation). Epithalamin been shown to regulate pineal gland function and increase melatonin production, improve immunological parameters, stimulate antioxidant and anti-cancer defenses, restore reproductive function, increase lifespan in animals and provide geroprotective effects in humans. (5) Epithalamin has been shown to act on the pineal

NAMES GIVEN TO THE PINEAL PEPTIDE: Original: Synthetic version (injections only): Oral/bovine version: Epithalamin Epithalon® Endoluten® The peptide names change on whether the peptide is synthetically produced or extracted from a bovine source. This table explains the situation in regard to the pineal peptide. Figure 2: names given to the pineal peptide.

6-OHMS excretion (ng/h) Age, years

Investigation**

Peptide Preparation Epithalamin

Epitalon®

Endoluten®

Initial value

410 ± 38 (n=21)

445 ± 43 (n=19)

428 ± 47 (n=17)

After treatment

933 ± 86*

915 ± 97*

820 ± 92*

Initial value

363 ± 41 (n=18)

371 ± 35 (n=22)

348 ± 43 (n=21)

After treatment

690 ± 63*

615 ± 71*

580 ± 62*

60-65

75-80

Figure 3: This figure highlights that all forms of the pineal peptide, whether administered by injection, or orally, increases human melatonin production, as measured in blood. Data on file: Laboratory of Biogerontology of the St. Petersburg Institute of Bioregulation and Gerontologytt.

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gland to restore youthful melatonin production, (figure 2) but has many other restorative effects on age-related endocrine dysfunction. For example, in aging rhesus monkeys receiving Epithalon® injections, night-time melatonin production increased and the normal daily pattern of cortisol secretion was restored, for an overall normalizing effect on circadian rhythms. (8) In another experiment on old rhesus monkeys, Epithalon® administration decreased glucose and insulin levels (both of which typically rise with age due to altered function of the pancreas) and as in the previous trial, increased night melatonin levels. (9) (See figure 3). Interestingly, Epithalamin also has positive effects on vision: it protects the functional integrity of the retina in rats (10) and improves visual function in patients with retinal degeneration in an impressive 90% of cases! (5,11) The restorative effects on both the pineal gland and retina probably reflect the common embryological origin of the two structures. Epithalamin also has positive effects on the age-related decline of the immune system by activating the proliferation of lymphocytes (a type of white blood cell) in the thymus. (12) It has also been shown to complex with the nucleotide sequence of the interferon gamma gene, activating interferon gamma production. (12) This is an excellent example of the molecular model of peptide-DNA bonding we reviewed earlier that results in the manufacture of a critical protein- in this case, in-

terferon gamma, which is a cytokine, or chemical messenger, involved in the regulation of nearly all phases of immune and inflammatory responses. Several trials have demonstrated the anti-carcinogenic effects of Epithalamin in countering genetic mutations and the development of malignant tumors. For example, Epithalon® treatment decreased the incidence of chromosome aberrations which can lead to tumors in senescence-accelerated mice, (mice which are bred as models of rapid aging), (13) and suppressed breast cancer in mice (14) and colon cancer in rats. (15) THE PINEAL PEPTIDE EXTENDS TELOMERE LENGTH Perhaps even more compelling, Epithalamin activates the telomerase gene and lengthens telomeres - (see figure 3) further evidence of its longevity-promoting potential. Aging is associated with a decrease in the proliferative capacity of cells (i.e., the ability of cells to divide, necessary for the construction and repair of tissues) due to the progressive shortening of structures called telomeres. Telomeres are the protective ‘caps’ at the ends of chromosomes that maintain their structural integrity and telomerase is an enzyme that adds repetitive DNA sequences to the telomeric ends of chromosomes each time a cell divides (during cell division, portions of DNA are lost due to an inherent problem of incomplete end-replication; telomerase ensures the complete copying of DNA repeats).

THE INFLUENCE OF PINEAL GLAND PREPARATIONS ON TELOMERE LENGTH IN PATIENTS’ BLOOD CELLS Telomere length (b.p.) Age, years

Investigation

Peptide Preparations Epithalamin

Epitalon®

Endoluten®

Initial value

9,32 ± 0,82 (n=25)

9,61 ± 0,93 (n=19)

9,43 ± 1,12 (n=21)

After treatment

10,83 ± 1,12*

10,72 ± 1,21*

10,62 ± 1,32*

Initial value

7,33 ± 0,81 (n=21)

7,51 ± 0,91 (n=17)

7,63 ± 0,98 (n=18)

After treatment

8,73 ± 0,78*

8,91 ± 1,11*

8,66 ± 1,21*

60-65

75-80 * - p< 0,05 as compared to initial value

Figure 4: Professor Khavinson’s experiments show that all versions of the pineal peptide extend telomere length. These are blood samples taken from patients from the age of 60 to 80. Data on file: Laboratory of Biogerontology of the St. Petersburg Institute of Bioregulation and Gerontology.

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Most of the body’s cells (excluding reproductive cells) can divide only a finite number of times according to a programmed genetic clock that results in decreased telomerase production with increasing age, leading to shortened telomeres and arrested cell division. This process, known as replicative senescence, ultimately leads to aging and age-related diseases. Khavinson found that the addition of Epithalamin to cultured human cells activated the telomerase gene to synthesize telomerase, resulting in lengthened telomeres and an increased number of cell divisions. (16, 17) This is another example of the molecular mechanism of peptide-DNA complexing which results in the synthesis of a protein, in this case the ‘immortalizing’ enzyme telomerase. According to Professor Khavinson; “these results indicate the possibility of prolonging the life span

of a cell population and of the whole organism” (16) - an intriguing and exciting prospect. All of these mechanisms - normalization of endocrine function, immune enhancement, cancer inhibition and telomerase activation - underlie the pineal peptide’s pronounced geroprotective, or antiaging effects. Studies specifically on longevity demonstrate increased life span in drosophila, (2,5) mice, (5) and rats (16) when administered Epithalamin and it follows that this effect is mimicked in humans. Undoubtedly, the peptide bioregulator is one of the most innovative and effective antiaging therapies developed in the past few decades. We can now take advantage of these fascinating physiologically-active short peptides - including the pineal version - to rejuvenate age-damaged organs and extend the quality and quantity of our senior years.

“We can now take advantage of these fascinating physiologically-active short peptides - including the pineal version - to rejuvenate age-damaged organs and extend the quality and quantity of our senior years.” REFERENCES 1. Anisimov V.N., Khavinson V.Kh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11:139-149. 2. Khavinson V.Kh., Anisimov V.N. Peptide Regulation of Aging: 35-Year Research Experience. Bulletin of Experimental Biology and Medicine. 2009;148:94-98. 3. Khavinson V.Kh., Kuznik B.I., Ryzhak G.A. Peptide Bioregulators: A New Class of Geroprotectors. Message 1: Results of Experimental Studies. Advances in Gerontology. 2013;3(3):225-235. 4. Khavinson V.Kh., Lin’kova N.S., Trofimov A.V., Polyakova V.O., Sevost’yanova N.N., Kvetnoy I.M. Morphofunctional Fundamentals for Peptide Regulation of Aging. Biology Bulletin Reviews. 2011;1(4):390-394. 5. Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. 6. Khavinson V.Kh., Solov’ev A.Yu., Zhilinskii D.V., Shataeva L.K., Vanyushin B.F. Epigenetic Aspects of Peptide-Mediated Regulation of Aging. Advances in Gerontology. 2012;2(4):277-286. 7. Khavinson V.Kh., Tarnovskaya S.I., Linkova N.S., Pronyaeva V.E., Shataeva L.K., Yakutseni P.P. Short Cell-Penetrating Peptides: A Model of Interactions with Gene Promoter Sites. Bulletin of Experimental Biology and Medicine. 2013;154(3):403-408. 8. Goncharova N.D., Lapin B.A., Khavinson V.Kh. Age-Associated Endocrine Dysfunctions and Approaches to Their Correction. Bulletin of Experimental Biology and Medicine. 2002;134(5):417-421. 9. Goncharova N.D., Vengerin A.A., Khavinson V.Kh., Lapin B.A. Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas. Experimental Gerontology. 2005;40:51-57. 10. Khavinson V.Kh., Razumovsky M.I., Trofimova S.V., Razumovskaya A.M. Retinoprotective Effect of Epithalon in Campbell Rats of Various Ages. Bulletin of Experimental Biology and Medicine.2003;135(5):495-498. 11. Khavinson V., Razumovsky M., Trofimova S., Grigorian R., Razumovskaya A. Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. Neuroendocrinology Letters. 2002; 23(4):365-368. 12. Lin’kova N.S., Kuznik B.I., Khavinson V.Kh. The Peptide Ala-Glu-Asp-Gly and Interferon Gamma: Their Role in Immune Response during Aging. Advances in Gerontology. 2013;3(2):124-128. 13. Rosenfeld S.V., Togo E.F., Mikheev V.S., et al. Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice. Bulletin of Experimental Biology and Medicine. 2002;133(3):274-276. 14. Khavinson V.Kh., Anisimov V.N. Peptide Regulation of Aging: 35-Year Research Experience. Bulletin of Experimental Biology and Medicine. 2009.148:94-98. 15. Kossoy G., Zandbank J., Tendler E., et al. Epitalon and colon carcinogenesis in rats: Proliferative activity and apoptosis in colon tumors and mucosa. International Journal of Molecular Medicine. 2003;12(4): 473-477. 16. Khavinson V.Kh., Bondarev I.E., Butyugov A.A. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bulletin of Experimental Biology and Medicine. 2003;135(6):590-592. 17. Khavinson V.Kh, Bondarev I.E, Butyugov A.A., Smirnova T.D. Peptide Promotes Overcoming of the Division Limit in Human Somatic Cell. Bulletin of Experimental Biology and Medicine. 2004;137(5):613-616.

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Dr Ward Dean Answers your questions We are delighted that Ward Dean M.D., one of the world’s foremost antiaging physicians, has agreed to answer our readers’ questions. Full details about Dr. Dean can be seen at his website: www.warddeanmd.com

Q. Dear Dr. Dean, I am a man in my mid-50s and my job involves reading a lot of technical materials. Recently I’ve found my concentration waning and I’m easily distracted, with boredom easily upon me. Is there anything you can recommend that could help me regain my focus and concentration again? It would be greatly appreciated. A.M., Japan

A. Dear Mr. A.M., One cause of foggy thinking and poor concentration can be subclinical (or overt) hypothyroidism. See the attached list of hypothyroid symptoms in figure 1, (adapted from Dr. Broda Barnes’ book, Hypothyroidism, the Unsuspected Illness). (1) If many of the symptoms apply,

you might consider treatment with Armour® thyroid, as outlined by Dr. Richard Wilkinson in his article; The Hypothyroid Epidemic, in issue #4, 2014 of the Aging Matters™ Magazine. A second suggestion is phenytoin (Dilantin®). Although phenytoin is a time-honored anti-seizure medication, one of its lesser-known properties is its ability to restore focus and attention. A series of studies by different investigators in the 1970s demonstrated the ability of phenytoin to enhance concentration and focus. In a double-blind study of 47 “retardates,” Goldburg and Kurland reported strong improvement in ability to maintain attention and concentration, using a dose of 100 mg of phenytoin twice daily.(2) Another study, using the same dose, reported phenytoin was useful for symptoms of lack of attention

and concentration.(3) A third double-blind study of the effects of 100 mg of phenytoin twice daily on the mental functions of elderly persons in the “normal-bright normal in the “middle and lower-upper socio-economic group” resulted in “significant improvement in long-term memory and social comprehension, increased ability to learn new material and increased speed in visual-motor coordination, improved general mental functioning and marked improvements in concentration.” (4) You might also consider one of the eugorics, or “alerting drugs.” Eugeroic means good arousal. Drugs in this class include modafinil (Provigil®), armodafinil (Nuvigil®), or the less expensive prototype, adrafinil (Adra-Pro®). These drugs are psychostimulants with a waking effect, prescribed to shift work-

ers and patients suffering from narcolepsy with cataplexy. Adrafinil was the first of this class, developed in France and still available in Europe, but which has never been approved in the U.S. Modafinil and armodafinil are analogs of adrafinil and are both available by prescription in the U.S. All of these drugs have mood-elevating and memory-enhancing effects, in addition to maintaining mental alertness. They are used “off label” to treat memory loss due to demen-

16. Headaches - moderate to severe 17. Poor short term memory and concentration 18. Arthritis, joint pains 19. Low blood pressure 20. High blood pressure 21. High cholesterol or atherosclerosis 22. Diabetes 23. Hypoglycemia 24. Low libido

25. Anxiety - panic attacks 26. Depression - moderate to severe 27. Behavioral and emotional disorders 28. Wounds that heal slowly 29. Menstrual problems (include PMS or hysterectomy) 30. Infertility 31. Enlarged thyroid-goiter 32. Acne 33. Lateral halves of eyebrows missing

Figure 1 (below): Hypothyroidism is a condition of insufficient output from the thyroid gland. Broda Barnes, M.D., Ph.D., (perhaps the most famous thyroid researcher and author of Hypothyroidism: The Unsuspected Illness), reports that the symptoms related to low thyroid vary widely and may include those shown in the table. Why not check all that apply to you?

Do you have the symptoms of hypothyroidism? 1. Sensitivity to cold - especially in the hands and feet 2. Fatigue - reduced energy levels 3. Weight gain 4. Inability to lose weight despite constant dieting 5. Infections - especially respiratory infections 6. Frequent bouts of cold or flu 7. Asthma and allergies

8. Decreased perspiration 9. Dry, coarse, leathery skin; pale 10. Poor circulation 11. Coarse hair or hair loss 12. Dry eyes - blurred vision 13. Swelling or puffy eyelids 14. Digestive problems, irritable bowel syndrome, or acid indigestion 15. Constipation

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tia, ADHD, jet lag and fatigue caused by extended work hours or illnesses. A recent article recommended that; “modafinil [and presumably the other members of this class] can be used by anyone who wishes to work late and/ or concentrate for a long time.” (5) I hope this helps, Ward Dean, M.D. References 1. Barnes B, and Galton, L. Hypothyroidism, the Unsuspected Illness. 1972, Harper and Row, New York 2. Goldberg JB, Kurland AA. Dilantin treatment of hospitalized cultural-familial retardates. J Nerv Ment Dis. 1970 Feb;150(2):133-7. 3. Daniel R. Psychiatric drug use and abuse in the aged. Geriatrics. 1970 Jan;25(1):144-5. 4. Smith WL, Lowrey JB. Effects of diphenylhydantoin on mental abilities in the elderly. J Am Geriatr Soc. 1975 May;23(5):207-11. 5. Kim D. Practical Use and Risk of Modafinil, a Novel Waking Drug. Environ Health Toxicol. 2012; 27.

Q. Dear Dr. Dean, May I please have your opinion on the relevance of piracetam as a smart drug? Do you feel that it still ‘stands up’ despite being many decades old, and have any of the new nootropics surpassed it in anyway? S.F., California

A. Dear SF, That’s a very good question. As you said, piracetam has been around for a long time - since 1972. I first learned about piracetam in Korea, (where I graduated from medical school in 1978). At that time, carbon monoxide poisoning was a common occurrence, due to leakages from the Korean in-floor heating systems. The standard method of treatment was a combination of intravenous piracetam and hyperbaric oxygenation. Although piracetam has been available generically for many years, research into its properties for a wide range of clinical conditions has continued. In Hungary in 2000, a Phase IV clinical study of 104 patients with mild cognitive impairment-dementia participated in a double-blind

study of piracetam, 4800 mg/day for 4 weeks, followed by 2400 mg/day thereafter. Five factors of the modified Mini-Mental State examination were evaluated. Nearly all factors significantly improved with piracetam- especially memory, concentration and psychomotor speed. The cognitive enhancement effects appeared in a few weeks, and were most pronounced in patients with depressive symptoms. (1) Belgian scientists in 2002 conducted a meta-analysis of nineteen double-blind studies of patients suffering from dementia or age-related cognitive impairment treated with piracetam. The authors concluded that the treatment demonstrated meaningful clinical improvement, with compelling evidence for the global efficacy of piracetam. (2) In 2005, Polish scientists reviewed the documented benefits of piracetam, affirming that it improves alertness, learning, memory, brain metabolism and capacity. They reported that piracetam alters plasma membrane properties by increasing membrane fluidity and protects the cell against hypoxia, increases red cell deformability and normalizes hyperactive platelet aggregation, resulting in anti-thrombotic, neuroprotective and rheological properties. The scientists theorized that these properties resulted in the efficacy of piracetam in various disorders including dementia, vertigo, sickle cell anemia, myoclonus and stroke, improves reading comprehension and accuracy in dyslexic children, socialization and IQ in elderly psychiatric patients, and is even used to treat alcoholism. (3) Also in 2005, piracetam’s properties were reviewed by a scientist from the Karolinska Institute in Sweden, who echoed the above review from Poland.

(4) In 2014, a team of Chinese scientists conducted a meta-analysis of three studies of piracetam used preventively prior to coronary artery bypass grafting (CABG). (5) Cognitive dysfunction of varying degrees is an unfortunately too-common side effect of this procedure. Between 25 and 80% of patients who undergo CABG surgery develop postoperative cognitive dysfunction (POCD), ranging from slight to pronounced disturbances that may persist for several weeks up to several years. Three studies were identifiedtwo in Germany and one in Romania - in which piracetam was administered prior to surgery to prevent the resultant cognitive dysfunction. In the first trial in 2003 in Germany, physicians administered 12 gm piracetam (or saline, placebo) via IV infusion to 64 patients 3 hours prior to undergoing bypass surgery. The authors reported that the piracetam-treated patients produced a better level of performance in short-term memory and attention 3-days after surgery, compared to the placebo group. (6) In 2006, Romanian physicians administered piracetam or placebo intravenously (150 mg/ kg daily; 300 mg/kg on the day of surgery) to 98 patients, from the day before surgery to 6-days after surgery, then orally (12 g/ day) up to 6 weeks after surgery. The authors reported that six weeks after CABG, cognition was significantly improved in those treated with piracetam compared to placebo. (7) In 2008, another team of German physicians performed a third study of piracetam’s ability to prevent cognitive dysfunction due to bypass surgery. This study was the largest, comprised of 120 patients, each of whom

received 12 grams of piracetam or placebo just prior to the surgery. Again, the piracetam patients performed significantly better compared to the placebo patients after the operation, and had less decline of overall cognitive function. (8) From 2010-2013, a series of papers was produced by an international team including scientists from Germany, Italy, France, Switzerland, China, Australia and the U.S., who investigated the mitochondrial resuscitating mechanisms of piracetam as a further explanation of its neuroprotective properties. In the first paper in this series, the authors showed that piracetam prevented decreases in mitochondrial membrane potential (MMP) and fall in ATP production associated with β-amyloid accumulation, suggesting that improving mitochondrial function protected against the neurodegeneration induced by β-amyloid (Aβ) (involved in Alzheimer’s disease). The brains of animals treated with piracetam showed markedly decreased loads of Aβ. Aβ-induced mitochondrial dysfunction also causes impairment of neuritogenesis and the Aβ-induced reduction of neurite growth was substantially improved by piracetam. The authors concluded that piracetam’s ability to improve mitochondrial function was a valid approach to ameliorate the detrimental effects of Aβ on brain function. (9) In the second paper, the authors reviewed piracetam’s ability to improve interhemispheric transfer, enhance cerebral resistance to hypoxia, (as I observed in Korea during treatment of carbon monoxide poisoning) and most importantly, to facilitate learning and other cognitive functions. The authors reported that the cognition-improving properties represent the

“ The cognitive enhancement effects [of piracetam] appeared in a few weeks, and were most pronounced in patients with depressive symptoms.”

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“...a combination of piracetam with a Russian cognitive-enhancer named Cerebral resulted in an increase in the lifespan and a delay in the appearance of brain degenerative processes...” most common therapeutic use of piracetam all over the world i.e., memory disorders, impaired cognitive functions after head injuries, and vertigo. In over four decades of piracetam’s clinical use, the cognition-improving properties have been found to be more pronounced when brain function is impaired, by aging, hypoxia, cerebral injuries, or Aß load in Alzheimer’s disease. The authors concluded that after more than 40 years’ use of piracetam, the new findings of mitochondrial protection provide a new perspective for this old nootropic and explain its continued use in many countries around the world. (10) In a third paper, the scientists again demonstrated that piracetam improved MMP (mitochondrial membrane potential), elevated mitochondrial ATP production, enhanced neurite outgrowth and reduced Aβ levels in several cell models (in vitro) as well as in mice (in vivo). They concluded that piracetam, (which they referred to as a “metabolic enhancer”) improves mitochondrial function following mitochondrial impairment typical for brain aging and early stages of AD. (11)

Piracetam has never been approved for clinical use in the U.S. Thus, it’s not surprising that all of the above-cited papers were from elsewhere. Nevertheless, in 2010, scientists from NovoMed Consulting, in Silver Spring, Maryland, aware of the increasing interest in nootropic drugs for the treatment of CNS disorders, undertook an analysis of evidence-based clinical investigations of piracetam performed during the previous ten years. They conducted a literature search of the following therapeutic categories of CNS disorders: (i) cognition/memory; (ii) epilepsy and seizure; (iii) neurodegenerative diseases; (iv) stroke/ ischemia; and (v) stress and anxiety. The scientists were unable to confirm that piracetam exhibited long-term benefits for mild cognitive impairments, but they affirmed the studies demonstrating piracetam’s neuroprotective effect during coronary bypass surgery and its efficacy in treating cognitive disorders of cerebrovascular and traumatic origin; and they found piracetam’s overall effect on lowering depression and anxiety was even higher than improving memory. As an add-

on therapy, piracetam appeared to benefit individuals with myoclonus, epilepsy and tardive dyskinesia and when used in combination with a vasodilator drug, piracetam appeared to have an additive beneficial effect on various cognitive disabilities. (12) Piracetam’s sales continue to rise. The most recent data I could find (from 2010-2011), indicated world-wide sales in 2011 were in excess of $120 million, with an approximate increase in sales of about 8% from 2010 (Figure 2). Although piracetam has been around for over 40 years, research into its mechanisms and clinical effects continues. It has a safety record equaled by few pharmaceuticals and the recent identification of its mitochondria-resuscitating properties and ability to restore cell and mito-

140

120

4 3

20 0

1 0 2010 Total

2011 Ann. Growth Total

Figure 2: Global sales of piracetam are still very significant at $120 million annually and they still appear to be growing.

Sales Growth (%)

VWV Sales: US $ (min)

7 100

References: 1. Tariska P, Paksy A. [Cognitive enhancement effect of piracetam in patients with mild cognitive impairment and dementia]. Orv Hetil. 2000 May 28;141(22):1189-93. 2. Waegemans T, Wilsher CR, Danniau A, Ferris SH, Kurz A, Winblad B. Clinical efficacy of piracetam in cognitive impairment: a meta-analysis. Dement Geriatr Cogn Disord. 2002;13(4):217-24. 3. Winnicka K, Tomasiak M, Bielawska A. Piracetam--an old drug with novel properties? Acta Pol Pharm. 2005 SepOct;62(5):405-9. 4. Winblad B. Piracetam: a review of pharmacological properties and clinical uses. CNS Drug Rev. 2005 Summer;11(2):169-82. 5. Fang Y, Qiu Z, Hu W, et al. Effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery: A meta-analysis. Exp Ther Med. 2014 Feb;7(2):429-434. 6. Uebelhack R, Vohs K, Zytowski M, Schewe HJ, Koch C, Konertz W. Effect of piracetam on cognitive performance in patients undergoing bypass surgery. Pharmacopsychiatry. 2003 May;36(3):8993. 7. Szalma I, Kiss A, Kardos L. Piracetam prevents cognitive decline in coronary artery bypass: a randomized trial versus placebo. Ann Thorac Surg. 2006 Oct;82(4):1430-5. 8. Holinski S, Claus B, Alaaraj N, et al. Cerebroprotective effect of piracetam in

chondrial membrane fluidity help to explain many of its neuroprotective and cognitive-enhancing effects and hint at its potential (but rarely-investigated) promise as a life-extending/ antiaging agent. In this regard, a Russian article reported that a combination of piracetam with a Russian cognitive-enhancer named Cerebral resulted in an increase in the lifespan and a delay in the appearance of brain degenerative processes in Drosophila melanogaster - although the flies were unaffected by Cerebral alone - implying that the life-extending effect was due entirely to piracetam. (13) So, yes, I think piracetam still “stands up” to the competition especially when combined with other cognitive enhancers. Ward Dean, M.D.

patients undergoing coronary bypass surgery. Med Sci Monit. 2008 Nov;14(11):PI53-7. 9. Kurz C, Ungerer I, Lipka U, et al. The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by ß-amyloid peptide. Br J Pharmacol. May 2010; 160(2): 246–257. doi: 10.1111/j.1476-5381.2010.00656.x 10. Leuner K, Kurz C, Guidetti G, et al. Improved Mitochondrial Function in Brain Aging and Alzheimer Disease – the New Mechanism of Action of the Old Metabolic Enhancer Piracetam. Front Neurosci. 2010; 4: 44. Published online Sep 7, 2010. doi: 10.3389/ fnins.2010.00044 11. Stockburger C, Kurz C, Koch KA, et al. Improvement of mitochondrial function and dynamics by the metabolic enhancer piracetam. Biochem Soc Trans. 2013 Oct;41(5):1331-4. doi: 10.1042/ BST20130054. 12. Malykh AG, Sadaie MR. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders. Drugs. 2010 Feb 12;70(3):287312. 13. Plakhta EL, Kushnir AG, Maksimov DV, et al. [Dynamics of neurodegenerative processes and lifespan under the action of Cerebral combined with other pharmaceuticals in Drosophila melanogaster mutants]. Eksp Klin Farmakol. 2009 Mar-Apr;72(2):16-9.

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PIRACETAM The Original Nootropic

PiraCETAM

We offer the original UCB brand called Nootropil and a blister packed generic PiraPro:

PiraPro™ (Piracetam)

Piracetam was the first nootropic and despite being one of the very first products that IAS offered when we launched in 1991, it still remains one of our best sellers to this day! Why? Because it is a very beneficial memory agent that has a great safety record, with very few side effects, plus it is cost effective.

100 x 800mg tablets $17.99

Nootropil® Piracetam 800 60 x 800mg Tabs $27.99

Nootropil Liquid Piracetam 100ml 20 grams Liquid $21.49

SPECIAL OFFERS* Pira-Pro save $3.00 only $14.99 limited time Nootropil tablets save $3.00 only $24.99 limited time Nootropil liquid save $2.00 only $19.49 limited time

(*Oﬀers end June 30th 2015)

SPOTLIGHT: CAN-C

™

A B R E AK THROUG H FOR C ATAR AC T Can-C™ eye-drops are the original™ brand- developed by Innovative Vision Products (IVP). This group were the first to research, publish and prove how eye-drops can reduce and even eradicate cataract. Accordingly there are active US and EU patents (and others pending) on this unique and special product. Unique formula:

Clinical trial:

Improving eye-sight:

Can-C™ eye-drops are the formula from the original published human trials. They contain a purified and racemized form of n-acetylcarnosine (made in Japan); this natural di-peptide has potent anti-glycating and antioxidant properties that prevents lipid peroxidation. Note that the formula is important- it’s not all about the n-acetylcarnosine; the specific carrier agents and their purity are also important. If you look at the Can-C™ formula you will see differences to the copycats, (remember it is only Can-C™ that is patented in recognition of the original work). If you want the best possible results in the fastest possible time, then choose Can-C™ to deliver them according to the clinical trials.

Patients placed two-drops of Can-C™ into their eyes twice daily for a 6-month period, the outcome was:

More evidence is mounting that Can-C™ is efficacious for many conditions including:

• 90% saw an improvement

in their visual acuity. • 88.9% of patients showed improvement in the clarity of their lens. There have been numerous reports of cataract shrinkage and even disappearance with documented evidence that Can-C™ eye-drops remain effective (and safe) more than 24-months later. The most commonly expressed initial reports are that glare is significantly improved, (for example night driving is much safer) and color perception is enhanced.

• Cataracts (particularly the senile version) • Glaucoma • Presbyopia • Corneal disorders • Eye strain • Ocular inflammation • Blurred vision • Vitreous opacities and lesions • Diabetes mellitus complications • Contact lens users • Dry eye syndrome Of special interest may be to persons who wear contact lenses. This is because Can-C™ inhibits the accumulation of lactic acid and therefore contacts can be worn for longer periods without pain.

Before:

We have also received reports that Can-C™ not only aids dry-eye syndrome with its lubricants, but that Can-C™ helps to unclog proteins from the lacrimal ducts, thus releasing more natural tears onto the eye. In a similar way, it is also believed that the unclogging of proteins in the eye’s drain, (the Schlemm valve), helps to reduce intraocular pressure and thus aids glaucoma.

Above: Can-C Plus capsules

After:

Right: A woman’s eye shows the cataract before treatment. Far Right: 5-months later after use of Can-C eye-drops (two drops twice daily), there is no longer a visible cataract and eyesight has improved.

Dr. Kyriazis book, ‘The Cataract Cure’, details the usefulness and evidence of Can-C™ eye-drops. It is now available as a FREE e-book at:

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SPOTLIGHT: GHRPS A R E AL ‘OR AL’ ALTER NATIVE TO G H INJEC TION S Ever since Dr. Rudman’s work in the 1980s and then the release of Dr. Klatz’s book ‘grow young with HGH’ in the 1990s, there has been a strong interest in the use of growth hormone (GH) in antiaging medicine. Dr. Rudman’s research concluded that after injecting his elderly patients with GH, many of them had reversals of their biological age markers by as much as 20-years; specifically having noted improved skin, hair, muscle mass, decreased fat levels and enhanced levels of stamina, strength and well-being. It’s not entirely surprising given the multi-faceted role of growth hormone, plus as its name suggests it is involved in the growth and repair of tissues, but unfortunately blood levels of it decline dramatically past the age of 35 (see figure 1), despite the fact that there is evidence that the pituitary gland continues making significant amounts of it.

GH injections

The issue with injecting GH, (brand names include Genotropin®, Saizen® and Zomacton®), other than its expense, is that it does have to be injected to be effective, this is because as a 191 chain amino-acid it simply can’t be absorbed via any other route, thus daily injections can become a chore. Furthermore, many countries have decided that GH injections be classified as a controlled substance, partly because of its anabolic actions. Controlled substances often require special import and export licenses; this is overand-above the requirement for a prescription. Furthermore, the research of Dr. Richard Walker has highlighted that bolus injections of GH are not

bioidentical and that as they induce spikes of GH into the blood they could end up damaging the pituitary gland, leading to a down-regulation of its own production of GH, or even to stop GH production altogether.

GHRPs

But meanwhile, Dr. Walker’s research has shown that the use of GHRPs, (growth hormone releasing peptides) have a much safer profi le whilst enjoying the same benefitseven if they provide them a little more slowly. We would recommend that you read his extensive article in the Aging Matters™ magazine, No3, 2014 to understand fully how they operate. What we can say is that GHRPs, (GHRP2, GHRP6 and sermorelin) have the following benefits: • They can be sublingually, intra-nasally and even orally, passing into blood and thus avoiding the need for needles. • Their feedback loop means that they cannot cause the pituitary to down-regulate. • GHRPs are not controlled substances. • Rather than inducing a spike of GH in the blood, GHRPs augment (improve) each release of GH naturally into the blood, for which there are several peaks daily, (although the rising from bed peak is the highest one) - see figure 2.

Synergy

Sermorelin is actually the precursor to GH, being the first 29 amino acids and is

applied via the sublingual route. Sermorelin’s function may be to release existing stores of GH from the pituitary- rather than encourage more production as a pure agonist would. Dr. Walker has highlighted that combining sermorelin with GHRP2 or GHRP6 has a highly synergistic effect, in some cases eliciting up to a 5x greater quantity of GH into blood, an action that can be equivocated to using injectable GH itself. Note: You can also hear Dr. Walker discuss this with us on the IAS video page.

Diﬀerences

There is no definitive answer yet as to the specific differences between GHRP2 and GHRP6; our own experiences, including information received from physicians and patients who use these products suggests the following: • GHRP6 may induce more hunger feelings than GHRP2 and could improve levels of IGF-1 more. Therefore this option may be better recommend for those Figure 1 (top): The typical GH levels in blood with age, note that ‘geriatric’ levels are reached as early as during the 30’s. Figure 2 (middle) shows the 24 hour profile of subcutaneous (and also intravenous) GH. Compare that to figure 3 (bottom), the natural peaks of GH in both young and elderly patients. Only GHRPs naturally amplify these bioidentical patterns.

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who want to put on muscle mass. • GHRP2 may create less hunger feelings and therefore could be preferable to those who want to stimulate GH for fat loss. Also as the GHRP6 (Releasing-Pro™) is a nasal spray, those who don’t like that feeling may prefer GHRP2-Pro™ since it is an oral liquid simply swallowed.

Summary

GHRPs have created a genuine efficacious alternative; they are simpler/ easier to use and at the same time they have a better/ safer profi le than injectable GH.

SPOTLIGHT: THYROID SUPPORT FOR THE HYPOTHYROID EPIDEMIC Dr. Broda Barnes in the 1970s estimated that 40% of the adult population was deficient in thyroid hormones; he published this statement in his excellent book‘hypothyroidism, the unsuspected epidemic.’ Since then, pupils of Dr. Barnes, such as Dr. Richard Wilkinson, have suggested that this figure could be even greater now! This is important because the thyroid gland is of pivotal importance to our overall health, but like the majority of hormones as we age the production of thyroid hormones decline. This lack of thyroid function is the root cause of a wide variety of agerelated health disorders. Ergo, supplementation with a synthetic or a natural thyroid can have a significant positive effect on a wide range of age-related problems.

The importance of the thyroid gland The hormones produced by the thyroid control the body’s metabolism- the rate at which it burns calories for energy. It also controls the body’s utilization of fat, so a decline in the secretion of hormones from the thyroid gland, (known as hypothyroidism) can result in wide range of symptoms such as poor concentration, confusion, memory problems, cold hands and feet and weight gain. Another serious condition which can be caused by and result from an underactive thyroid are painful musculoskeletal issues that affect tendons, muscles and ligaments.

How can I be sure if I need a thyroid supplement? Above: The position of the thyroid gland

thyroid checked, but another, simpler method is to take your body temperature when you wake in the morning. It should be in the range of 97.8 to 98.2 degrees Fahrenheit, if it is regularly lower you could be hypothyroid and if higher then hyper-thyroid.

Choosing between synthetic and natural thyroid supplements IAS stocks a comprehensive range of both synthetic and natural thyroids, although we advocate the use of a natural supplement over a synthetic, this is because products such as Armour® are of a porcine origin, so they naturally contain the full spectrum of T1, T2, T3 and T4 thyroid hormones, (note the bottles only list the amounts of T3 and T4 because very few physicians are familiar with T1 and T2).

Thyroid doses Natural desiccated thyroids are measured in grains; with one grain being equivalent to approximately 60 mg. IAS carries doses from ¼ grain to 2 grains, with brands including Armour®, ERFA® and Nature®. IAS also provides synthetic T3 in 20 mcg and T4 in 100 mcg tablets.

Thyroid supplements provide potent antiaging protection Many aging individual can benefit from taking a thyroid supplement because this remarkable hormone has such a profound affect across so many different conditions. Many antiaging physicians consider thyroid support an essential part of any serious attempt to improve a person’s healthspan and longevity.

Apart from recognising the types of effects listed above, your doctor can of course get your blood levels of

Conversion between synthetic and natural thyroid products The table provided is a helpful guide to what the suggested conversion rates are for those wishing to make the switch between synthetic thyroids and natural versions. As always we recommend consulting with a physician before making changes to your program.

Dose of Desiccated thyroid (grains)

Equivalents (mg)

Dose of T3 (lithyronine) (mcg)

Dose of T4 (levothyroxine) (mcg)

0.5

12.5

100

130

200

300

260

100

400

325

125

500

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50mcg 8.7mg

Melatonin

90 58

3mg Amount Per Serving

* % Daily Value

Servings per container: 60 Serving Size: 1 tablet

Supplement facts:

Description: MZS is Dr. Walter Pierpaoli’s original melatonin formula containing the additional and supportive agents zinc and selenium. MZS is produced to pharmaceutical standards in Italy and unlike other melatonin preparations MZS has been designed to produce a night peak of melatonin between 1AM and 3AM to mimic the natural behavior of the pineal gland. Dr. Pierpaoli’s extensive animal and human research has shown that this is important because this action helps to stabilize circadian rhythms, improve hormonal cyclicity and boost immunity.

MZS

www.profound-products.com

Dr. Pierpaoli’s original formula+

™

Formulated and distributed by Profound Products, PO Box 19, Sark GY9 0SB, Great Britain

MZS Dr. Pierpaoli’s original formula ™

Dr. Pierpaoli

MZS Dr. Pierpaoli’s original formula

Dr. Pierpaoli MZS Dr. Pierpaoli’s original formula

™

Directions: Take 1 tablet before bedtime, ideally between 10PM and 11PM.

% Daily Value * not established Other ingredients: Avicel, mannitol, povidonum and magnesium sterate Selenium Zinc

Dr. Pierpaoli MZS Dr. Pierpaoli’s original formula

Disclaimer: This product and its statements have not been evaluated by the FDA. This product is not intended to treat, cure or prevent any disease.

B EC AU S E NOT ALL MEL ATONIN S AR E CR E ATED EQUAL

Note: Keep in cool dark conditions, out of the reach of children and consume before end of expiry date. Not for use by pregnant or lactating women.

SPOTLIGHT: MZS

™

Our melatonin has been formulated by the world’s foremost melatonin expert Dr. Walter Pierpaoli, his Melatonin Zn Se, or MZS™, is totally unique since it is designed to mimic the natural night peak of melatonin- to leave you feeling refreshed and alert the following day.

What does Melatonin do? Melatonin is vital to protect our hormonal system, regulate immunity and repair our body’s cells. It is commonly used by shift workers and also to treat jet lag and age related sleep disorders, but its abilities go far beyond simply its sleep inducing properties.

The antioxidant eﬀects of melatonin Melatonin is an extremely effective antioxidant; in fact on a molecule to molecule basis; melatonin has proved to be significantly more efficient in neutralizing toxic

hydroxyl-radicals than the two well-known free radical scavengers, glutathione and mannitol.

many showed reversal of their ARMD. Remarkably this was true for both the wet and dry forms!

Melatonin’s eﬀects on longevity

Why is Dr. Pierpaoli’s MZS™ more eﬀective than other melatonin supplements?

Melatonin’s effect on longevity is well documented; in fact laboratory tests on rats and mice have demonstrated that melatonin increased their lifespans by 20%. Experts believe melatonin is a vital antiaging product because of its positive effect on aging. MZS™ and age-related macular degeneration Age related macular degeneration (ARMD) comes in two forms, wet and dry and is a notoriously difficult disorder to treat and is linked to blindness. A 24-month study, (published in NY Academy of Science, 2005, 1057:384-392) on 100 patients showed that after 3 months, the majority of patients taking 3 mg of Melatonin Zn Se nightly had halted the progression of their age related macular degeneration and at 6 months

There are three principal reasons, firstly it is of pharmaceutical quality at a dose of 3 mg, secondly it contains the synergistic ingredients of selenium and zinc, but thirdly and most importantly- it is designed to release at a very specific time. Dr. Pierpaoli’s research led him to perfect a formula that exactly mimics the pineal gland’s release of melatonin. Thus means that MZS™ is the only melatonin supplement to follow nature’s own night peak.

60 tablets Dietary Supplement

™

Melatonin is produced by the pineal gland at night to regulate our circadian rhythm, (sometimes called the sleep wake cycle). As we age the amount of melatonin we produce reduces resulting in many older people sleeping less and having a lower quality of sleep.

Dr. Pierpaoli

MZS Dr. Pierpaoli’s original formula ™

Dr. Pierpaoli

MZS™ is so much more than a sleep aid

Melatonin has had so many published benefits it is impossible to list them all here. From jet lag and shift work to well-being and antiaging, no other melatonin supplement offers the endorsement of Dr. Pierpaoli, or the exact formula used in all of his renowned clinical trials. If you’ve tried other melatonin and didn’t notice any significant effect, then we highly recommend you try Dr Pierpaoli’s MZS™ for a superior experience. Dr. Pierpaoli’s free ebook ‘The key of Life’ can be read here:

http://bit.ly/1vdB31y

How much should I take?

Take half to one 3 mg tablet at bedtime only; do not take more than two tablets. By taking MZS™ between 9pm and 11pm you will create a night peak between 1am and 3am, this is the most natural and normal time to have the highest melatonin levels.

Left: Melatonin age decline graph

This graph compares Dr Pierpaoli’s melatonin formula (red line) to the natural release of melatonin (dark blue). Two other common types of melatonin supplements (light blue and green lines) demonstrate that sublingual melatonin peaks too soon and that time released formulas peak too late.

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Above: Here are some before and after Fundus photos showing the benefit of Melatonin Zn Se. (Top before, below: after treatment).

SPOTLIGHT: SMART DRUGS AND NUTRIENTS DEPR ENYL FOR FOCU S AND CONCENTR ATION Deprenyl is also known as selegiline, it was created in the 1960s by Professor Joseph Knoll from Hungary, principally as an aid to Parkinson’s patients - because deprenyl has a significant benefit to improve dopamine levels in the brain. Dopamine is the neurotransmitter most affected in Parkinson’s disease, in fact, deprenyl still remains a front line treatment for that disease.

Significant longevity studies

the book, Smart Drugs and Nutrients I), produced figure 2. It highlights that the loss of dopamine in humans with age, can be mapped against both the development of Parkinson’s and even death.

Mode of action

Professor Joseph Knoll; now aged in his 90s but still active in pharmacological research.

Professor Knoll’s experiments with rats produced some of the most incredible longevity benefits that have ever been seen. When they were fed deprenyl in their food, they lived so much longer than those that were not, so much so, that even after the last non-treated rat died, the first of the deprenyl treated rats was yet to die! These results are shown in figure one: Note; interestingly and importantly, these results were verified independently in another study not conducted by Professor Knoll. Based on this research, Dean, Fowkes and Morgenthaler, (as published in

For a long time deprenyl has been expressed as a MAO-b inhibitor, that it to say that is prevents the enzyme monoamine-oxidase type-b from destroying dopamine, ergo leading to its greater availability in the brain. The inhibition of the more common MAO-a can be problematic, leading to something called ‘the cheese effect,’ therefore this is not a side effect of deprenyl, although it should be noted that dopamine can inhibit type-a, but usually only at very high doses of 20mg. In more recent times, Professor Knoll has noted that there is another significant action of deprenyl and this is the raising, (albeit briefly) of PEA levels. PEA is a catecholamine activity enhancer that raises norepinephrine levels; this is

a significant attention agent that is behind the primary mechanism of the famous Eugeroic drug- modafinil (Provigil®). To learn a great deal more about dopamine and deprenyl, we would recommend Professor Knoll’s books; ‘the brain and its self’, or ‘how selegiline/ deprenyl slows brain aging.’

Typical patient responses In patients who have mild cognitive impairment, or age related minor cognitive dysfunction, the most common report is of a significant improvement in their focus and concentration. Persons with higher dopamine levels often appear more ‘driven’ and ‘dedicated.’ Avoid overuse since it can lead to what may appear to be an oppressive behavior, as others around you are not so focused and ‘on the ball’ as you! This is why we recommend occasional breaks from deprenyl use, some advocate one week off in the month and others use it during the weekdays but not at the weekends.

Dopamine Level (%)

% of animals alive

100

Deprenyl Treated Rats

Control Rats

25 0 140

150

160

170

180

190

200

210

220

Age of rats in weeks

100 90 80 70 60 50 40 30 20 10 0

Average Parkinson’s Patients Rapid Parkinson’s Patients

Dosing Doses are as normal, based upon need and age. Whilst Parkinson’s patient will require large doses, a person wanting to improve their cognitive performance may want to typically consider 1mg to 3mg per day, with occasional breaks. Note: These doses do not take into account synergy with other dopamine enhancing agents and persons using antidepressants should consult with their physician beforehand. Deprenyl tablets are typically provided in 5mg form (Jumex®); some persons like to take ½ to 1 of these tablets 3-times a week; however the use of the deprenyl liquid (Dep-Pro™) is particularly attractive for those using deprenyl to generally support, protect and improve neurological function, since 1 drop = 1mg. Therefore the liquid can be dosed very precisely by simply placing those drops into a cold drink. Avoid use in the late evening to prevent any sleep disruption.

Slow Aging People Normal People

PARKINSON’S SYMPTOMS DEATH 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140

Figure 1: Professor Knoll’s experiment showed that when deprenyl is given to animals it significantly extends their lifespan and their latter life activity.

Figure 2: For humans, the normal loss of dopamine past the age of 40 is 13% per decade. As the lines suggest, if we all live long enough we all become senile!

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SPOTLIGHT: BIOIDENTICAL HORMONES OX Y TOCIN FOR PA SS ION AND S E X IAS carries a wide range of bioidentical hormones - a term that means ‘natural to and in the body’. In this featured section we are focusing on oxytocin. What is oxytocin? Oxytocin is a hormone produced by the hypothalamus, but excreted via the pituitary gland. Its orthodox medicine role is to help women give birth, since the large dose that’s injected helps relaxes the uterus and alleviates the passage of the child into the world for the mother.

Above: Dr. Thierry Hertoghe

However, as we will discover and as been highlighted by Dr. Thierry Hertoghe’s book; ‘passion, sex and longevity, the oxytocin adventure’ -it has many other roles to play too.

The love hormone Oxytocin has been dubbed ‘the love hormone’, why would this be? Principally because oxytocin can induce feelings of bonding and care and not just between

individuals, but even with animals too! Oxytocin measurements have been taken between lovers, friends, relatives, parents and their children etc. From those results, it has been noted that oxytocin levels are higher when they are in their presence. Mothers naturally bond with their children, but even men, (especially those who experience the live birth), express their emotions as wanting to care and protect their offspring, these effects may be attributable to the release of oxytocin hence triggering the bond. On the other side of the coin, psychopaths are notoriously low in their oxytocin levels, which may be a cause of their uncaring feelings towards other humans.

The pain and orgasm connection Fibromyalgia can be a very debilitating disorder with a lot of pain, sometimes constant for those who suffer with it. In women it was noted that when they were experiencing an orgasm they felt no pain at all. Later, it transpired that women

undergo a burst of oxytocin during orgasm. Trials were undertaken to see if oxytocin supplementation could alleviate the pain of fibromyalgia, there was some success, but the side-effect noted was that those women now enjoyed multiple orgasms! This was a fact picked up on by the popular press and is probably singularly the action most responsible for bringing oxytocin into the public gaze.

Synergy Dr. Hertoghe has explained that some folks will not feel the effects of oxytocin. This is principally because of two reasons, (if we consider that the dose is correct for that individual). Firstly, that some people are ‘low’ in their own principal sex-hormone, so if a man is low testosterone, or if a woman is low estrogen, it is possible that oxytocin will not elicit its full potential in those persons. The other issue could be low vasopressin; vasopressin

Dosing As might be expected doses are very dependent upon its use. However for social or sexual enhancement, one can consider 5 IU to 10 IU a ‘typical’ dose. In fact, Dr. Hertoghe has somewhat reduced the doses that he recommends in his book, (transmitted via personal conversation to me). Currently IAS is providing Oxy-Sub™ in 20 IU trouches (a soft sublingual tablet), these can therefore be cut into half or quarter for a dose of 5 or 10 IU and should be placed under the tongue and allowed to melt. The other option is Oxy-Pro™ which is applied intranasally delivering 10 IU per spray.

Dr. Thierry Hertoghe’s book, “Passion, sex and longevity - the oxytocin adventure”, details its roles and uses in a ‘how to’ guide form.

“...oxytocin can induce feelings of bonding and care and not just between individuals, but even with animals too!” 30

is a counterpart to oxytocin, produced and released via the same glands. In cases of vasopressin deficiency, the patient may enhance the oxytocin experience by adding one or two sprays (10 IU each) of vasopressin via the Vaso-Pro™ nasal spray.

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SPOTLIGHT: YOUTH GEMS ® THE PEP TIDE B IOR EG U L ATOR S FOR S KIN Those who are already familiar with the work of Professor Vladimir Khavinson from the St. Petersburg Biogerontology Institute in Russia, will know how remarkable his work has been in the discovery of short-chain peptide bioregulators- that act as highly specific gene switches. Now, four of these peptide bioregulators have been combined into topical skin preparations so that their performance can be bought to the field of aesthetic medicine; specifically the peptides in use are those from: • Cartilage • Blood vessels • Thymus gland • Pineal gland

What does each peptide provide for? The beauty product line Youth Gems® contains the listed peptides and a ginseng extract called Neovitin®. They represent the very latest developed program of complex skin care designed for the face, neck, hands and the body. The line includes four unique active ingredients of short-chain peptides that have a directed tissue-specific action to improve all basic skin structures: • The thymus gland peptide stimulates tissue regeneration and the synthesis of tissuespecific proteins. Thus, cells proliferative and metabolic activity is enhancedaccelerating the renewal of various cell tissues. It also has an anti-inflammatory action, improving the healing time of wounds, as well as antioxidant, immune stimulating and antistress actions. • The pineal gland peptide regulates metabolic processes and increases protein synthesis in skin cells. It also possesses potent antioxidant activity, normalizes the lipid peroxidation processes in skin cells that in turn promotes the elimination of negative

influences on the skin from external factors. • The cartilaginous tissue peptide stimulates regeneration of fibroblasts and keratinocytes and interferes with the destructive changes in collagen skin structure; it also strengthens collagen structure of elastic skin fibers and increases elasticity. • The vessel peptide regulates metabolic processes in the vascular wall, normalizes vascular tone and restores disturbed skin microcirculation. It strengthens and regulates the permeability of the vascular walls of skin vessels and improves skin turgor.

What else is included in Youth Gems® in addition to the four peptides? In addition to the four peptides, the Youth Gems® also contain an incredible array of beneficial natural agents- which just by themselves would make other antiaging creams jealous! The range includes: Neovitin® (a complex isolated from ginseng), olive oil, raisin-seed oil, Argon oil, Soya oil, Jojoba oil, Bisabolol (extract from chamomile), Peony extract,

sodium hyaluronate (a derivative of hyaluronic acid), green tea extract, cocoa oil, carrageenan (from seaweed), winter bloom, almond extract and vitamin E.

What results have been seen? Clinical trials and examinations have been conducted at the St. Petersburg Biogerontology Institute and they have concluded that these short chain peptides, when applied to skin cells, have many beneficial activities, shown below are some of those results. These include improved metabolism in vascular wall cells, the growth of new skin cells, enhanced antioxidant activity; increased blood flow circulation and greater moisturization. The skin’s appearance becomes smoother, with fewer wrinkles and with more elasticity, all of which helps to lift the face contours producing a more radiant, youthful appearance. These beneficial effects were noted in 100% of women who took part in the voluntary clinical trial.

What’s available? • Body milk: The body milk is a very light cream that can be applied to most areas of the body. • Day cream: The day cream is the core product designed to be applied to the face and hands. • Serum: The serum is designed to be used sparingly against the most noticeable skin aging effects on the face and neck. • Tonic: This cleanser can be used to help any area become more firm and taught and may be splashed on as required. All of the Youth Gems® should be applied onto clean, dry skinavoiding the eyes; makeup can be applied after absorption - if required.

Right: A 68 year old female before (left) and after (right) application of Youth Gems®

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SPOTLIGHT: BIOCUFF

™

MONITOR ING YOU R VA SCU L AR CONDITION The BioCUFF™ is a simple way of assessing both your blood pressure condition and your arterial flexibility; plus, you can use the BioCUFF™ in the comfort of your own home because you simply attach the device to your arm just like an ordinary blood pressure cuff. What does the BioCUFF™ measure? The BioCUFF™ provides a series of metabolic indicators that you can use to improve your lifestyle and so help to prevent the causes of cardiovascular disease. We all know the risks of being overweight, of having high cholesterol or suffering from high blood pressure. We also know how to reduce those risks – by exercising more, not smoking, reducing our alcohol intake and eating a balanced diet.

These include: • Diastolic blood pressure • Systolic blood pressure • The heart rate • Vascular condition – which linked to arterial flexibility. Few of us know about the hidden dangers of arterial inflexibility, or how to measure it. This is where the BioCUFF™ is unique being as it is the first at-home

Above: The BioCUFF™ readout, showing both blood pressure, heart rate and vascular flexibility results.

device able of delivering this information to you within minutes.

What is arterial flexibility? The BioCUFF™ works by evaluating your arterial flexibility, which experts say is one of the most important risk factors when it comes to assessing the likelihood of a heart attack or stroke. Arteries are important because they’re responsible for blood flow around your body via your cardiovascular system. To work properly, it’s crucial that your arteries are kept healthy.

The poorer your vascular condition, the greater your chances of serious health issues

You may not recognise the heart failure symptoms as your arteries begin to stiﬀen Unfortunately arterial stiffness can occur without warning. Often there are no symptoms of cardiovascular disease and people don’t suspect they are in danger until they suffer an attack. Figure 2 highlights that arterial stiffness is strongly correlated with mortality The BioCUFF™ provides a cardiovascular condition scale, shown by LED bars- that are either within the green zone (good), yellow zone (fair) or red zone (poor). It is important to note that like blood pressure,

vascular condition should be monitored over time and not just taken as one reading. The BioCUFF™ makes this simple by averaging your tests over time and therefore provides a more accurate result. BioCUFF™ provides reassurance and a vital early warning system that helps you to be aware of changes and therefore keep your vascular condition in check.

Left: Arterial stiff ness is a biomarker of aging, as shown here arterial stiff ness tends to increase with age. Source: Millasseau et al., Clinical Science, 2002.

Our arteries usually stiffen with advancing age. This brings with it a greater risk of a potentially fatal heart attack, heart failure or stroke, as is shown in figure 1.

Left: Three groups (each approximately 80 persons) were monitored over 140 months for their survivability. Those in the flexible artery groups (marked as PWV <9.4 m/s and 9.4-12.0 m/s) survive best losing approx. 25%. But those in the hard artery group (marked as PWV >12.0 m/s) 90% of them die in the same period. Source: ESRD, Blacher et al. Journal of Circulation, 1999

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SPOTLIGHT: PEPTIDE BIOREGULATORS THE DI SCOVERY OF G ENE SWITCHES IN FOOD Today Professor Vladimir Khavinson is the President of the European Academy of Gerontology and Geriatrics, but in the 1980’s he was a Colonel in the Soviet Union military medical corps. At the time, he and his team were approached by Kremlin officials, they wanted them to find a way to protect their troops from a myriad of problems; issues such as radiation for submariners in nuclear submarines to troops that may be blinded from known, (but thankfully unused) new weapons such as battlefield lasers.

A former Soviet military secret! What their research uncovered - that was used for two decades on many thousands of men and women - was a remarkable link between short chain peptides and DNA. This former military secret is now available to the public as peptide bioregulators. Their published research has identified that each organ / gland / tissue uses a highly specific short chain peptide, obtained from food, to act as a ‘short-cut’ to initiate protein synthesis. These peptides, unlike proteins, can enter the blood through the stomach. Through a comprehensive list of patents and even copyrighted PowerPoint slides, the Russian research group have shown that each of the concentrated

Above: A short-chain peptide bioregulator interacting with DNA

peptide bioregulators so far examined, interact with particular strands of DNA - effectively and very specifically activating repair and regenerative processes. This is a remarkable story since what we are describing here are peptides that act as individualised gene switches. To date, they have been tested for many years on thousands of individuals, without report of any serious side effects or contraindications. We believe that they could be set to ‘out do’ stem cells. Why? Because this peptide therapy is relatively cheap, highly specific, can be taken orally and doesn’t require any suppression of the immune system to operate fully (as stem cells do).

Original material from the trials The peptide bioregulators available via IAS are the bovine originals; sourced from carefully chosen Danish calves and processed through pharmaceutical processes and filters. They are not the synthetic versions which have not been studied/ proven. Peptide bioregulators act as they sound- to regulate; for example, Thyreogen®

the thyroid peptide would increase thyroid activity if it were too low, but decrease it if it were too high!

Dosing Doses are very dependent upon the need and unlike hormones these peptides do not have to be taken every day, hence making them a cost effective regime. A typical/ average use could be considered as follows:

• Start with an intensive course: 2 capsules once a day for 30-days. • Thereafter use 2 capsules once a day for 10-days, repeat every 2, 3, 4 or even as little as 6-months. The story of the peptide bioregulators is a remarkable one and we recommend that you to read the articles and interviews and see the video on the IAS website.

PEPTIDES CURRENTLY AVAIL ABLE: Cerluten® is the... Chelohart® is the... Chitomur® is the... Endoluten® is the... Glandokort® is the... Gotratix® is the... Libidon® is the... Pielotax® is the... Sigumir® is the... Suprefort® is the... Stamakort® is the... Svetinorm® is the... Taxorest® is the... Testoluten® is the... Thyreogen® is the... Ventfort® is the... Visoluten® is the... Vladonix® is the... Zhenoluten® is the...

brain peptide bioregulator. heart peptide bioregulator. bladder peptide bioregulator. pineal peptide bioregulator. adrenal peptide bioregulator. muscle peptide bioregulator. prostate gland peptide bioregulator. kidney peptide bioregulator. cartilage peptide bioregulator. pancreas peptide bioregulator. stomach mucus peptide bioregulator. liver peptide bioregulator. lung peptide bioregulator. testes peptide bioregulator thyroid peptide bioregulator. blood vessel peptide bioregulator. retina peptide bioregulator. thymus peptide bioregulator. ovary peptide bioregulator.

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SPOTLIGHT: SMART DRUGS AND NUTRIENTS PIR ACE TAM, THE ORIG INAL NOOTROPIC Smart drugs and nutrients, or to give them their correct medical terminologynootropics, are agents that can not only improve conditions of senile dementias, but in recent times have become popular for older individuals to improve their mental and cognitive processes. It was Ward Dean, M.D. who highlighted these facts through his very popular ‘Smart Drug’ series of books in the 1980s, since then the term ‘smart drugs’ has become mainstream.

Piracetam, the original nootropic The smart-drug we focus on here was in fact the first, developed as it was by Dr. Giurgea for UCB laboratories in Belgium in the 1960s. Originally it was designed to assist with travel and altitude sickness, but shortly afterward individuals realised that piracetam had positive cognitive enhancement effects.

What can piracetam do for me? Piracetam is a cognition agent that has been used successfully to treat a wide

range of conditions, for example it has been shown to increase a person’s attention levels and improve memory and intelligence. Piracetam can help to slow down ‘senile involution’, dementia and Alzheimer’s disease. In tests and trials, piracetam induces significant improvement to memory consolidation and recall in those suffering from ‘age-associated memory impairment’. Piracetam has also been used to improve patient’s recovery from strokes, particularly improving post stroke speech impairment (aphasia). Another use has been in cases of acute and chronic cerebral ischaemia, (decreased blood flow to the brain). Using piracetam has restored speech and the use of limbs in these patients; it has also increased neuronal activity in the brain when measured with EEG. For regular individuals, piracetam has been shown

to enhance idea creation and the ability to ‘see things through,’ in other words to have ideas and being them to fruition. The level of clarity piracetam creates is often described/ perceived as; “the fog has lifted.”

How does piracetam work? Piracetam’s key and unique method of action is upon the Corpus Callosum, the region of the brain that links the two hemispheres. It is this that most experts believe is the key that gives piracetam users the ability to channel greater brain potential by connecting the logical side of the brain with the creative side more effectively, Yin and Yang if you will.

“Piracetam can help to slow down ‘senile involution’, dementia and Alzheimer’s disease.” 34

Right: The Corpus Callosum

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What are the doses of piracetam? A common dose is 800mg tablets three times a day, then lowering to 800 mg twice a day after the first month. Note: The effects of piracetam can be enhanced if taken concurrently with centrophenoxine or Hydergine®. Side effects are minimal and seldom experienced, but should you experience nausea or headache then it is usually caused by an overdose, so in which case reduce the dose and build up more slowly, (if it is necessary). Note: There are many articles and videos on the IAS website about smart drugs and nutrients.

SPOTLIGHT: BIOIDENTICAL HORMONES NATU R AL ESTROG EN S AND PROG ESTERONE FOR WOMEN IAS carries a wide range of bioidentical hormones - a term that means ‘natural to and in the body’. In this featured section we are focusing on the use of natural estrogens and progesterone for women, which of course are normally utilised to aid the menopause. When hormone replacement therapy (HRT) was developed in the 1920s, estrogens had to be derived from horse urine because a laboratory solution was too difficult/ expensive to synthesize. But today everything has changed, yet this ancient practice continues- these facts have been pointed out by Dr. Wright in his best-selling book ‘Stay Young & Sexy’ Horse estrogens are, as you might expect, not identical to human; after all humans don’t have manes nor do they have hooves! Yet the industry is stuck in this old loop, despite the fact that natural (bioidentical) estrogens can be easily produced now. Some people believe that the known side-effects from ‘traditional HRT’ are due to the fact that the hormones given are not correct.

Esnatri™, a unique tri-estrogen Esnatri™ is our bioidentical triple estrogen cream, which many women use, confident they have chosen the best bioidentical estrogen cream available. It comes directly from the work of Dr. Wright who has shown that the majority of women produce estrogens in the ratios of 90% estriol, 7% estrone and 3% estrone.

Above: As Dr. Wright himself has said many times; “we only have to copy nature, the right molecules at the right times and doses.”

Most tri-estrogen preparations attempt to replicate the human hormones estriol, estradiol and estrone, apply them in the ratio of 80:10:10, while some even entirely over-

Above: Stay Young & Sexy By Dr. Wright

look estriol, claiming it is a weak estrogen. But, women naturally produce high levels of estriol and it is considered to have anticarcinogenic effects.

Esnatri™ use The Esnatri™ cream can be applied by daily rotation to your neck, upper chest, breasts and behind the knees, or inner thighs. A typical starting dose is 2 mg, start from day one (of what would have been the start of your menstrual cycle) and continue until day 25. Then you should stop for five days, before repeating the application at the start of the next menstrual cycle. During these last few days, the estrogen receptors are being allowed to ‘rest’ as they have been accustomed.

Progesterone Progesterone is the counterbalance to estrogens. Indeed, whilst women can significantly decline in estrogen levels during menopause- they rarely reach zero production levels, whereas progesterone can

sometimes not be measured at all in elderly women. It is also the low of progesterone that most significantly impacts bone strength, leading onto osteoporosis, so there are numerous reasons to ensure that progesterone is also taken alongside an estrogen therapy. IAS provides a 5% strength natural progesterone cream. Typical doses are 25 mg to 30 mg of progesterone applied on day 10 and continuing to 25. The start date varies according to the usual timing of your ovulation. Note: As with the Esnatri™ cream, stop for the last five days of your cycle so that the estrogen receptors have their accustomed ‘rest’ period. Remember, your hormone replacement therapy should be overseen by a physician and should not be undertaken if you have undergone cancer treatment.

“Esnatri™ is our bioidentical triple estrogen cream, which many women use, confident they have chosen the best...” www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

A-Z PRODUCT LIST OTHER INFO KEY: Not shipped to UK Not shipped to EU

Not shipped to Japan Not shipped to Australia (or New Zealand)

PRODUCT

CONTAINS

1ST LINE™ (OSCN, THIOCYANATE)

Not shipped to Canada

RETAIL PRICE

IAS PRICE

1 complete kit

$90

$79.99

5HTP (5HTP-PRO™)

90x 100mg capsules

$25

$22.49

ACARBOSE (GLUCOBAY®)

30x 100mg tablets

$30

$27.49

ACF228™

50 capsules

$60

$49.99

ACF228™ BREATHE-EASY

1 inhaler

$160

$149.99

ADRAFINIL (ADRA-PRO™)

40x 300mg capsules

$59

$49.99

ALDOSTERONE - NEW: ALDO-SPRAY™

5ml 10mg ear spray

$160

$149.99

ALDOSTERONE

15x 125 mcg capsules

$99

$94.99

AMINOGUANIDINE (AMINO-PRO™)

90x 75mg tablets

$29

$24.99

ANACERVIX (VINCAMINE + PIRACETAM)

30x 420mg capsules

$29

$24.99

ANASTROZOLE

28x 1mg tablets

$149

$139.99

ANASTROZOLE (ANASTRO-PRO™)

28x 100mcg capsules

$39

$34.99

ANDRO-PRO™

60 capsules

$55

$49.99

ANI-PRO™ (ANIRACETAM)

20x 750mg capsules

$35

$31.49

ATP (ADENOSINE TRIPHOSPHATE) ATP-BOOST™

60x 20mg tablets

$35

$29.99

B12 (VITAMIN B12) CROMATONBIC ®

8x 1mg i.m. ampoules

$20

$17.49

BEC5 CURADERM ®

20ml tube cream

$160

$144.99

BENFOTIAMINE (MILGAMMA MONO)

30x 50mg tablets

$25

$22.49

BHT (BUTYLHYDROXYTOLUENE) NEW: BHT-PRO™

120x 10mg capsules

$24

$21.49

BIO-CUFF™

one complete kit

$150

$149.99

BIO-CLIP ™ V2.00

one complete kit

$1500

$1249.99

BOLUOKE ® (LUMBROKINASE)

60 capsules

$108

$94.99

BONE-PRO2™

60 capsules

$35

$31.49

BROMOCRIPTINE (PARLODEL)

30x 2.5mg tablets

$29

$24.99

CABERGOLINE (DOSTINEX)

8x 0.5mg tablets

$80

$74.99

CAN-C™ (EYE-DROPS)

2x 5ml vials

$45

$39.99

CAN-C™ PLUS

90 capsules

$40

$34.99

CENTROPHENOXINE (CENTRO-PRO™)

60x 250mg

$35

$29.99

CEREBROLYSIN ®

5x 5ml i.m. ampoules

$95

$84.99

CIALIS ® (TADALAFIL)

4x 20mg tablets

$85

$79.99

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

OTHER INFO

PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

CIPROFLOXACIN (CIPROXIN)

10x 500mg tablets

$35

$32.49

COLCHICINE (COLCRYS ®)

40x 1mg tablets

$19

$17.49

COQ10 (COENZYME Q10) COQ10SR™ (SLOW RELEASE)

30x 100mg capsules

$30

$25.99

CURCUMIN (TURMERIC EXTRACT) CURCUMIN-SR™ (SLOW RELEASE)

30x 125mg capsules

$25

$22.49

D3 (VITAMIN D) D3-5000™

100x 5000 IU capsules

$19

$14.99

D3 (VITAMIN D) D3-PRO™

12x 50,000 IU capsules

$30

$24.99

DEPRENYL (SELEGILINE) JUMEX®

50x 5mg tablets

$65

$54.99

DEP-PRO™ (DEPRENYL/ SELEGILINE)

20ml/ 300mg bottle

$90

$84.99

DERCOS® SHAMPOO (AMINEXIL)

200ml bottle

$29

$22.49

DESMOPRESSIN (MINURIN )

2.5ml nasal spray

$39

$34.99

DIGESTIF™

60 capsules

$19

$14.99

DI-INDOLYMETHANE (DIM) DIM-PRO2™

100 capsules

$49

$44.99

DOXYCYCLINE

8x 100mg capsules

$29

$24.99

DUTASTERIDE (AVODART®)

30x 0.5mg tablets

$85

$79.99

EDTA NEW: EDTA PRO™

120x 10mg capsules

$24

$21.49

ESNATRI™ (BIO-IDENTICAL ESTROGENS)

50ml 100mg cream

$55

$49.99

FINASTERIDE

28x 5mg tablets

$40

$37.49

FINASTERIDE (PROSCAR ®)

15x 5mg tablets

$45

$39.99

FLUCONAZOLE (DIFLUCAN ®) LOITIN ®

7x 50mg capsules

$39

$34.99

FLUDROCORTISONE (FLUDRO-PRO™)

100x 20mcg tablets

$24

$19.99

FOODSAFE ® COMING SOON

Food allergy blood

$260

$219.99

OTHER INFO

test-kit for 95 foods

GABAPENTIN (NEURONTIN )

100x 300mg capsules

$49

$44.99

GABOB (GAMIBETAL®)

20x 500mg tablets

$39

$34.99

GALANTAMINE (REMINYL®) GALANTAMINE-PRO™

30x 8mg capsules

$79

$69.99

GAMALATE B6 ®

60x 250mg tablets

$24

$19.99

GEROVITAL-H3 ®

5x 5ml ampoules

$59

$49.99

GEROVITAL-H3 ®

25x 100mg tablets

$35

$29.99

GH3-PRO™

60x 100mg tablets

$19

$14.99

GHRP2 NEW: GHRP2-PRO™

120ml 120mg liquid

$175

$159.99

GLUTATHIONE (ACG)

2 oz. spray

$45

$44.99

HAIR-PRO™

2 oz. spray bottle

$180

$169.99

HYALURONAN (HYALURONIC ACID) NEW: NOVISYN PLUS ®

30x 5ml liquid sachets

$30

$29.49

HYDERGINE ® (ERGOLOID MESYLATE) NEW: HY-PRO™

30x 4.5mg capsules

$45

$39.99

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

100x 5mg capsules

$35

$29.99

IDEBENONE (IDEB-PRO™)

60x 30mg tablets

$30

$24.99

INJECTION PACKS (INTRAMUSCULAR KIT)

30x pack

$30

$27.49

INJECTION PACKS (SUBCUTANEOUS KIT)

30x pack

$30

$27.49

LAETRILE (AMYGDALIN, VITAMIN B17) VITA-B17®

50ml 1% cream

$99

$89.99

L-CARNOSINE (CARNOSINE-PRO™)

60x 250mg capsules

$34

$29.99

LITHIUM (OROTATE) LITH-PRO™

100x 5mg capsules

$30

$24.99

L-TRYPTOPHAN (L-TRYP-PRO™)

50x 500mg capsules

$20

$17.49

MAGNESIUM NEW: MAGNESIUM-PRO™

2 oz. liquid 400mg

$13

$11.99

MELATONIN (MZS™)

60x 3mg tablets

$35

$21.49

MELATONIN NEW: MELA-SUB™

2 oz. liquid 90mg

$15

$11.49

HYDROCORTISONE HYDRO-PRO

NOTE: The UK can order melatonin in Pounds Sterling at: www.melatoninznse.com MEMANTINE (NAMENDA® ; EBIXA®) MEMANTINE-PRO™

42x 10mg capsules

$105

$89.99

METFORMIN (GLUCOPHAGE ®) METFORAL®

50x 500mg tablets

$25

$22.99

METFORMIN SR® (SLOW RELEASE)

56x 500mg tablets

$30

$27.99

MILNACIPRAN (SAVELLA®) IXEL®

56x 50mg tablets

$65

$59.99

MINERAL MOUTHWASH NEW: MIN-MOUTH™

16 oz. liquid bottle

$16

$14.99

MINSAW™ (MINOXIDIL +++)

30ml bottle topical liquid

$45

$39.99

MITO-PRO2™ NEW

75g powder

$49

$44.99

MOCLOBEMIDE (MANERIX®) MOCLAMINE ®

30x 150mg tablets

$29

$24.99

MODAFINIL - Please see www.modafinil-store.com for availability and pricing MSH (MELANOCYTE STIMULATING HORMONE) NEW: MSH2-PRO™

5ml 500IU nasal spray

$79

$69.99

NALTREXONE (NAVCOL®) NALTREX-PRO™

30x 4.5mg capsules

$70

$59.99

NEO40 DAILY®

30 lozenges

$60

$59.99

NEYDENT TOOTHPASTE

50ml tube toothpaste

$18

$15.99

NICERGOLINE (SERMION ®)

50x 10mg tablets

$50

$47.49

NITRIC OXIDE SALIVA TEST STRIPS (NEO40 ®)

10 saliva strips

$25

$24.99

NIZORAL®

60ml bottle shampoo

$19

$14.99

30x 100mg capsules

$19

$54.99

$65

$59.99

NADH NEW: COMING SOON!

(2% KETOCONAZOLE)

OXALOACETATE NEW: OXALO-PRO™

OXYTOCIN (OXY-SUB™) NEW PACK SIZE COMING SOON OXYTOCIN (OXY-PRO™)

5ml 500 IU nasal spray

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OTHER INFO

PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

PENICILLIN (PENILEVEL®)

30x 250mg sachets

$34

$29.99

PEO (PARENT ESSENTIAL OILS) NEW: PEO-PRO™

120 capsules

$44

$39.99

20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules

$85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $85 $99 $85 $85 $85 $85 $85

$74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $74.99 $89.99 $74.99 $74.99 $74.99 $74.99 $74.99

PHENYTOIN (DILANTIN ®, EPANUTIN ®) PHEN-PRO™

30x 25mg capsules

$25

$19.99

PICAMILONE (PICAMILON-PRO™)

60x 50mg tablets

$25

$19.99

PIRACETAM (NOOTROPIL®)

20 grams 100ml liquid

$25

$21.49

PIRACETAM (NOOTROPIL®)

60x 800mg tablets

$30

$27.99

PIRACETAM (PIRA-PRO™)

100x 800mg tablets

$24

$17.99

POTASSIUM NEW: POTASSIUM-PRO™

2 oz. liquid 99mg bottle

$14

$12.99

PQQ (PYROLOQUINOLINE QUINONE) PQQ-PRO™

30x 20mg capsules

$44

$39.99

PULMOLIFE ® (FVC BIOLOGICAL AGE) PULMOLIFE ®

Spirometer + 4 tubes

$160

$139.99

PULMOLIFE ®

25 additional tubes

$25

$19.99

PRAMIRACETAM (PRAM-PRO™)

40x 300mg tablets

$55

$49.99

PREGNENOLONE (PREG-PRO™)

50x 100mg capsules

$25

$22.49

PROGESTERONE (PREG-PRO™)

50ml 2.5 grams (5%) cream

$35

$29.99

PROPRANOLOL (INDERAL®)

30x 50mg tablets

$25

$19.99

PROSTATE-PRO2™

60 capsules

$35

$29.99

PYRIDOXAMINE (PYRIDOX-PRO™)

60x 50mg tablets

$35

$29.99

PYRITINOL (CERBON 6 )

60x 100mg tablets

$29

$24.99

OTHER INFO

PEPTIDE BIOREGULATORS (ALSO SEE YOUTH GEMS®) ADRENALS (GLANDOKORT®) BLADDER (CHITOMUR ®) NEW BLOOD VESSELS (VENTFORT®) BRAIN (CERLUTEN ®) CARTILAGE (SIGUMIR ®) EYESIGHT (VISOLUTEN ®) HEART (CHELOHART®) NEW KIDNEYS (PIELOTAK®) LIVER (SVETINORM ®) LUNGS (TAXOREST®) NEW MUSCLE (GOTRATIX®) NEW OVARIES (ZHENOLUTEN ®) PANCREAS (SUPREFORT®) PINEAL (ENDOLUTEN ®) PROSTATE (LIBIDON ®) STOMACH (STAMAKORT®) NEW TESTES (TESTOLUTEN ®) THYMUS (VLADONIX®) THYROID (THYREOGEN ®)

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PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

RASAGILINE (AZILECT®) RASAGILINE-PRO™

30x 1mg capsules

$95

$89.99

REBOXETINE (DAVEDAX®) EDRONAX®

60x 4mg tablets

$70

$64.99

NEW: RELEASING-PRO™ (GHRP6)

5ml 500 IU nasal spray

$89

$79.99

RESVERATROL-SR™ (SLOW RELEASE)

30x 150mg capsules

$34

$29.99

RETIN-A (RETIRIDES® 0.025%)

30ml cream

$39

$29.99

RETIN-A® (RETIRIDES® 0.050%)

30ml cream

$49

$39.99

RETIN-A® 0.100%

20ml micro-gel

$80

$74.99

ROXITHROMYCIN (RULID ®)

10x 50mg tablets

$35

$29.49

SAME (S-ADENOSYL-L-METHIONINE) SAMYR ®

20x 400mg

$69

$64.99

SELENIUM NEW: SELENIUM-PRO™

2 oz. liquid 300mcg

$17

$15.49

SERMORELIN (SERM-PRO ®)

30ml 30mg liquid

$225

$199.99

SILVER PROTEIN (ADVANCED CELLULAR SILVER 200 ®)

2 oz. spray

$35

$34.99

STABLON ® (TIANEPTINE)

60x 12.5mg tablets

$69

$62.49

STEM CELL WORX® NEW

3.5ml liquid spray

$65

$64.99

SYMPROVE ® NEW

4x 500ml liquid bottles

$125

$124.99

TA65 ®

90 capsules

$600

$599.99

TETRACYCLINE (AMBRAMICINA®)

16x 250mg tablets

$25

$22.49

THYMUS (THYM-UVOCAL®)

90x 200mg capsules

$110

$99.99

Please note that this product has a shipping surcharge of $10 because of its weight.

THYROID - OUR NATURAL THYROIDS INCLUDE: ARMOUR ®

100x 15mg tablets 100x 30mg tablets 100x 60mg tablets 100x 90mg tablets 100x 120mg tablets

$79 $89 $99 $149 $169

$69.99 $79.99 $89.99 $139.99 $159.99

ERFA®

100x 30mg tablets 100x 60mg tablets 100x 125mg tablets

$59 $79 $99

$49.99 $69.99 $89.99

NATURE ®

100x 15mg tablets 100x 30mg tablets 100x 60mg tablets 100x 90mg tablets 100x 120mg tablets

$49 $55 $69 $79 $89

$39.99 $44.99 $59.99 $69.99 $79.99

EUTIROX® (T4)

100x 100mcg tablets

$34

$27.49

T3 NEW: T3-PRO™X

50x 20mcg tablets

$35

$29.99

TRH (THYROTROPIN RELEASING HORMONE) ABARIS™

20x 5mg sublingual tablets

$235

$209.99

VALDOXAN ® (AGOMELATINE)

28x 25mg tablets

$150

$144.99

OUR SYNTHETIC THYROIDS INCLUDE:

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OTHER INFO

PRODUCT

CONTAINS

RETAIL PRICE

IAS PRICE

VASOPRESSIN (VASO-PRO ®)

5 ml 500 IU nasalspray

$75

$69.99

VENLAFAXINE (EFEXOR ®)

28x 37.5mg tablets

$45

$39.99

VIAGRA® (SILDENAFIL)

4x 100mg tablets

$75

$69.99

VIELIGHT® (LASER)

633 inter-nasal laser

$300

$274.99

VINPOCETINE NEW: VIN-PRO™

120x 10mg capsules

$30

$27.49

NEW: VOLT-PRO™ (ELECTROLYTES)

8 oz. liquid bottle

$22

$19.99

WOBENZYM-N

200 tablets

$75

$69.99

XANTHINOL NICOTINATE (XAN-PRO ®)

50x 150mg tablets

$24

$17.49

YOHIMBINE (PLAIN PROWESS ®)

100x 5mg tablets

$59

$49.99

NEW: YOUTH GEMS ® BODY MILK

200ml bottle

$50

$44.99

NEW: YOUTH GEMS DAY CREAM

50ml pump

$70

$64.99

NEW: YOUTH GEMS ® SERUM

30ml dropper

$90

$79.99

NEW: YOUTH GEMS TONIC

200ml bottle

$45

$39.99

ZEOLITE (ADVANCED CELLULAR ZEOLITE ®)

2 oz. spray

$45

$44.99

ZINC NEW: ZINC-PRO™

2 oz. liquid 50mg bottle

$13

$11.99

OTHER INFO

DIDN’T FIND WHAT YOU WERE LOOKING FOR? PLEASE CONTACT US WITH YOUR REQUIREMENTS

BOOK

PAGES

IAS PRICE

GREAT TEETH FOR LIFE

169 pages

$19.99

PASSION, SEX, LONGEVITY AND OXYTOCIN

159 pages

$49.99

THE (PHYSICIAN) HORMONE HANDBOOK V2

833 pages

$449.99

THE PICTURE ATLAS OF ENDOCRINOLOGY

327 pages

$374.99

BY DR. BRIAN HALVORSEN

BY DR THIERRY HERTOGHE

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CONDITION CROSS-REFERENCE LIST This cross-reference list highlights individual products that have been used for these disorders. Note: It does not mean that all these products are synergistic together.

Addison’s disease Aldosterone, peptide bioregulator (Glandokort®) ADHD (ADD, attention deficit disorder, see mental stimulants) Adrenal fatigue Aldosterone, Digestif®, hydrocortisone, peptide bioregulator (Glandokort®) AGE (advanced glycated end-product inhibitors) ACF228™, aminoguanidine, Can-C™ Plus, carnosine, metformin, pyridoxamine Age Related Macular Degeneration (see eyesight) Age Related Mental Decline (see cognitive) AIDS (see HIV) Alcoholism (also see compulsive disorders) 5HTP, L-tryptophan, memantine Allergies pregnenolone, thymus, Wobenzym®

Arterial (See heart, arterial & blood) Arthritis (rheumatoid & osteo) Andro-Pro™, Gerovital-H3®, Novisyn®, PEO pregnenolone, pyritinol, SAMe, thymus, Wobenzym® Asthma (see Allergies) Autism (also see chelation agents) Oxytocin, piracetam Back problems (see spine) Blood disorders (see heart, arterial & blood) Blood pressure Neo40®, magnesium, oxytocin, potassium, propranolol, vinpocetine Bone problems (also see joints & arthritis) Andro-Pro™, Bone-Pro2™, Esnatri™, Peptide Bioregulator (Bonomarlot®), progesterone, SAMe, thyroid Breathing (see lungs)

Anabolic (see growth hormone & testosterone)

Cancer (also see anti-oxidants & radiation) 1st Line™, anastrozole, artemisinin, BEC5® Curaderm, bromocriptine, CurcuminSR™, D3, DIM-Pro2™, laetrile, melatonin, metformin, naltrexone, oxaloacetate, progesterone, Resveratrol-Pro™, thymus, TRH, Wobenzym®

Anginas (see heart, arterial & blood)

Cardiovascular (see heart & arterial disorders)

Animal use Can-C™ eye-drops, deprenyl, L-tryptophan, peptide bioregulators

Cataplexy (sudden fatigue) Adrafinil, modafinil, picamilone

Antiaging (as impacting on a particular theory of aging)

Cataract (also see eyesight) Can-C™, Can-C Plus™

ALS (amyotrophic lateral sclerosis, see Lou Gehrig’s disease) Alzheimer’s disease (see senile dementia)

Calorie Restriction Carnosine, metformin, resveratrol Free radical ACF228™ Glycation Aminoguanidine Hayflick Carnosine, TA65® Membrane Centrophenoxine Mitochondrial Hydergine®, PQQ Neuroendocrine Metformin, TRH Rotational Melatonin Telomeres Endoluten®, TA65® Anti-biotics Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline Anti-depressants Lithium, milnacipran, moclobemide, reboxetine, Stablon®, Valdoxan®, venlafaxine Anti-oxidants (see free radical scavengers) Anxiety (see stress)

Central Nervous System (CNS) Peptide bioregulator (Cerluten®) Cholesterol (see blood disorders) Crohn’s disease Naltrexone Chronic fatigue syndrome (see mental stimulants & physical energy improvement) Cognitive (also see memory & senile dementias) Alertness Adrafinil, modafinil Creativity Aniracetam, piracetam, pramiracetam Focus/concentration Deprenyl, desmopressin, vasopressin Energy ATP-Boost™, centrophenoxine, picamilone General support Gerovital-H3®, vinpocetine Intelligence Hydergine® Work load Hydergine®, thyroid

ARMD (see eyesight)

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Compulsive disorder treatment (also see alcoholism) 5HTP, Gamalate®, L-tryptophan, picamilone

Fertility Melatonin, metformin, peptide bioregulator (Zhenoluten®), TRH

Cortisol alteration (also see stress) Aldosterone, DHEA, fludrocortisone, GABOB, Gamalate®, Gerovital-H3®, hydrocortisone, peptide bioregulator (Glandokort®), phenytoin

Fibromyalgia (also see physical energy & mental stimulants & pain relief) 1st Line, milnacipran, naltrexone, oxytocin

Cross linking (see AGE)

Free radical scavengers ACF228™, ATP-Boost™, glutathione, idebenone, melatonin, Mito-Pro2™, pyritinol

Deep vein thrombosis (see frequent fliers)

Gastrointestinal (see digestive)

Dental (see teeth & gums)

Glaucoma (see eyesight)

Depression (also see well-being & anti-depressants) 5HTP, aniracetam, ATP-Boost™, CurcuminSR™, D3, deprenyl, Gerovital-H3®, lithium, L-tryptophan, milnacipran, picamilone, piracetam, pramiracetam, pregnenolone, SAMe, thymus, thyroid

Glucose control (see diabetes)

DHT alternation (dihydrotestosterone) Dutasteride, finasteride, Hair-Pro™, MinSaw™, Nanogens®, peptide bioregulator (Libidon®), progesterone Diabetes Acarbose, aminoguanidine, ATP-Boost™, benfotiamine, L-carnosine, metformin, PEO, peptide bioregulator-(Suprefort®), pyridoxamine, TRH, thyroid

Glycation prevention (see AGE) Gout Colchicine Growth hormone (improvement) Beyond GHS®, bromocriptine, deprenyl, GABOB, Gamalate®, GHRP2, GHRP6, hydergine, Neo40®, sermorelin, thymus, thyroid Hair improvement Dercos®, dutasteride, finasteride, Gerovital-H3®, Hair-Pro™, MinSaw™, Nizoral®, PEO Headaches (see migraines)

Diabetes insipidus (see urination)

Heath diagnostics (see at home test kits)

Dieting (see weight loss)

Hearing disorders Aldosterone, Anacervix®, fludrocortisone, nicergoline, picamilone, vinpocetine

Digestive issues Digestif®, peptide bioregulator (Stamakort®), Symprove® DNA support (also see telomeres) Carnosine, CoQ10, D3, PEO, peptide bioregulators, PQQ, resveratrol, TA65® Down’s syndrome Melatonin, piracetam Energy improvement (see physical energy & mental stimulants) Enzymes Boluoke®, Wobenzym® Epilepsy GABOB, Gamalate®, phenytoin Erectile dysfunction (also see sex-libido & premature ejaculation) Andro-Pro™, cabergoline, Cialis®, Neo40®, oxytocin, Viagra®, Vigor-Pro2™, yohimbine Eyesight ARMD MZS™ Cataracts Can-C™, Can-C™ Plus Contact lenses Can-C™ Dry eyes Can-C™ General support Aminoguanidine, peptide bioregulator (Visoluten®), vinpocetine Glaucoma Can-C™ Retinal MZS™, nicergoline, picamilone Retinal pigmentosa Picamilone, peptide bioregulator (Visoluten®) Excitotoxins (reduction) Carnosine, deprenyl, idebenone, lithium, memantine

Heart, arterial & blood (includes blood markers) Arteries (hard) Aminoguanidine, Bio-CLIP™, BioCUFF™, carnosine, resveratrol Blood pressure (high) Magnesium, Neo40®, potassium, Propranolol, vinpocetine Calcium Peptide bioregulator (Bobothyrk®) Cholesterol (high) CoQ10, Gerovital-H3®, TRH, XanPro™ Dilation (nitric-oxide) Neo40®, Vielight® Fibrinogen CurcuminSR™, TRH, Wobenzym® General support CoQ10, PEO, peptide bioregulators (Chelohart® & Ventfort®), PQQ, vinpocetine, Wobenzym® Glucose (high) Acarbose, metformin, TRH Glycated end-products Aminoguanidine, metformin Heart pulse (irregular) ATP-Boost™, thyroid Heavy metals (chelate) BCI®, Homocysteine: BCI®, TRH Lipofuscin Centrophenoxine Plaques (clots) Boluoke® Triglycerides CurcuminSR™, PEO, TRH Hepatitis (see liver and infections) Herpes (also see anti-biotics) 1st Line™, ACF228™, BHT, silver protein, Wobenzym® HIV (also see immune system improvement) 1st Line™, melatonin, naltrexone, thymus HGH (see growth hormone)

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HRT (hormone replacement therapy for women) Esnatri™, melatonin, progesterone

Mental stimulants (also see physical stimulants) Adrafinil, aniracetam, centrophenoxine, deprenyl, desmopressin, modafinil, nicergoline, picamilone, piracetam, pramiracetam, vasopressin, Xan-Pro™

Human growth hormone (see growth hormone)

Memory (also see cognitive & senile dementia)

Homocysteine (see blood disorders)

Hypertension (see blood pressure) Hypothyroidism Iodine, peptide bioregulator- thyroid (Thyreogen®), thyroids IBS (irritable bowel syndrome) Symprove® Immune system improvement (also see infections) 1st Line™, ATP-Boost™, carnosine, melatonin, peptide bioregulator- thymus (Vladonix®), peptide bioregulator- thyroid (Thyreogen®), pyritinol, resveratrol, thymus, thyroid Infections (also see immune system improvement, anti-biotics & influenzas) 1st Line™, artemisinin, fluconazole, silver protein, Wobenzym® Inflammation (reduction) BCI®, Boluoke®, CurcuminSR™, Digestif®, PEO, pregnenolone, thymus, Wobenzym® Influenzas (also see anti-biotics, infections & immune system improvement) 1st Line™, D3 Insulin & glucose control (see diabetes) Intestinal flora (see probiotics) Joints (also see bones & arthritis) Boluoke®, PEO, peptide bioregulator (Sigumir®), Novisyn®, pregnenolone, SAMe, thymus, Wobenzym® Kidney disorders (also see infections) Aminoguanidine, peptide bioregulator (Pielotak®) SAMe, TRH Learning (also see memory & mental stimulants) Aniracetam, desmopressin, Hydergine®, piracetam, pramiracetam, vasopressin

Methylation (conversion of one chemical into another inside the body) ATP-Boost™, Boluoke®, SAMe, Wobenzym®, Xan-Pro™ Migraines (also see pain relief) nicergoline, memantine, picamilone Mitochondrial support ATP-Boost™, CoQ10, deprenyl, glutathione, Hydergine®, idebenone, Mito-Pro2™, NADH, oxaloacetate, PQQ, pregnenolone, SAMe Mtor inhibitors Oxaloacetate Multiple Sclerosis (also see mitochondrial support) Melatonin, naltrexone, TRH Nail condition Gerovital-H3®, PEO Narcolepsy (sleeping in the daytime) Adrafinil, melatonin, modafinil, picamilone Nitric Oxide release Neo40®, Nitric Oxide saliva test strips, Vielight® laser Oral health care (see teeth & gums) Osteoporosis (see bone problems) Pain relief ATP-Boost™, Gerovital-H3®, memantine, milnacipran, nicergoline, oxytocin, Wobenzym®

Libido (see sex)

Parasites (see infections)

Lipids (see blood disorders)

Parkinson’s disease (see senile dementia)

Liver disorders (also see infections) CoQ10, Idebenone, peptide bioregulator (Svetinorm®), pregnenolone, SAMe, silver protein

Pets (see animal use)

Longevity enhancement (significant lifespan increases seen in animal studies) Centrophenoxine, deprenyl, melatonin, vasopressin

Physical energy improvement (also see mental stimulants) ATP-Boost™, carnosine, CoQ10, idebenone, Mito-Pro2™, NADH, oxaloacetate, PQQ, pregnenolone, SAMe, yohimbine

Lou Gehrig’s disease (ALS) Naltrexone, TRH Lungs ACF228™ Breathe-Easy, centrophenoxine, glutathione, peptide bioregulator (Taxorest®) Lupus Milnacipran, naltrexone Lyme’s 1st Line™, silver protein Macular degeneration (see ARMD & eyesight) Malaria (also see antibiotics) Artemisinin Menopause (see HRT)

General support PEO, picamilone, vinpocetine Imprinting (for later recall) Desmopressin, vasopressin Medium-long term Hydergine® Short term Aniracetam, piracetam, pramiracetam Speed of recall Centrophenoxine, pyritinol

Photoaging (see skin problems)

PMS (pre-menstrual syndrome) PEO, peptide bioregulator (Zhenoluten®), vinpocetine Premature ejaculation/ ejaculate (also see erectile dysfunction & sex-libido) Oxytocin Prostate (also see cancer) D3, DIM-Pro2™, dutasteride, finasteride, melatonin, peptide bioregulators – (Chitomur® & Libidon®), Prostate-Pro2™ Prolactin alteration Bromocriptine, cabergoline, GABOB, Gamalate®

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PSA (prostate specific antigen) (see prostate)

Sunburn (see skin problems)

Urination (frequent) Peptide bioregulator (Chitomur®), vasopressin

Syndrome X (metabolic syndrome) Aminoguanidine, ATP-Boost™, melatonin, metformin, PEO

RNA (see DNA support)

Tanning (darkening the coloration of skin) MSH

Senile dementia (also see cognitive & memory)

Teeth & gum disorders Doxycycline, mineral mouthwash, NeyDent® toothpaste, silver protein, zeolite

Alzheimer’s Centrophenoxine, CurcuminSR™, galantamine, Hydergine®, memantine, nicergoline General support Anacervix®, aniracetam, PEO, piracetam, pramiracetam, vinpocetine, Wobenzym® Parkinson’s Bromocriptine, cabergoline, NADH, deprenyl, rasagiline Senility Gerovital-H3®

Telomeres (also see DNA support) Carnosine, PEO, peptide bioregulator- pineal (Endoluten®), TA65® Testosterone & testes (also see fertility and prostate) Andro-Pro™, anastrozole, Beyond GHS®, DIM-Pro2™, melatonin, oxytocin, peptide bioregulator (Testoluten®), TRH, zinc

Sex (libido, also see erectile dysfunction & premature ejaculation) Andro-Pro™, deprenyl, MSH, oxytocin, yohimbine

Triglycerides (see blood disorders)

Skin problems (also see tanning)

Weight gain (muscle mass) Andro-Pro™, Beyond GHS®, GABOB, GHRP6, sermorelin

Acne: BG-Pro™ cream Age (liver) spots Centrophenoxine Anti-glycation Aminoguanidine, carnosine, Youth Gems® serum Anti-oxidant Youth Gems® day cream Cancer (non-melanoma) BEC5® Curaderm Cellulite Youth Gems® body milk Collagen Novisyn® Environmental Youth Gems® serum General support Gerovital-H3®, melatonin, PEO, thyroid Hyaluronic acid Novisyn® Infections Silver protein, thymus Moisturizer Youth Gems® day cream Sun spots BEC5® Curaderm Wounds HemaGel® Wrinkles Retin-A®

Veterinarian (see animal use)

Weight loss (appetite suppressants and diet aids) 5HTP, acarbose, aminoguanidine, ATP-Boost™, benfotiamine, DIM-Pro2™, galantamine, GHRP2, L-tryptophan, metformin, Mito-Pro2™, MSH2, thyroid, TRH, Xan-Pro™ Well-being (also see depression) 5HTP, aniracetam, ATP-Boost™, deprenyl, Gamalate®, Gerovital-H3®, L-tryptophan, melatonin, Mito-Pro2™, PEO, picamilone, piracetam, pramiracetam, SAMe, thymus, thyroid, Wobenzym®, zeolite

Sleep disorders For less sleep adrafinil, ATP-Boost™, modafinil For more sleep 5HTP, gabapentin, L-tryptophan, melatonin Smoking cessation 5HTP Spine issues Peptide bioregulator (Sigumir®), Novisyn® Sports (see growth hormone, estrogen alteration, physical energy & testosterone) Stress (also see cortisol) 5HTP, GABOB, Gamalate®, Gerovital-H3®, L-tryptophan, melatonin, oxytocin, picamilone, phenytoin, propranolol, pregnenolone Stroke Anacervix®, aniracetam, Boluoke®, Hydergine®, idebenone, nicergoline, picamilone, piracetam, PQQ, pramiracetam, pregnenolone, vinpocetine Stomach (see digestive)

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Centrophenoxine *Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

The Smarter Way to Combat Mental Decline

CentroPro™ $29.99 each Centrophenoxine is a Nootropic or smart drug proven to increase brain power, improve longevity and create an overall sense of mental alertness. Centrophenoxine ‘cleans out’ Lipofuscin the build-up of plaques in the brain, heart, lung and skin cells that accumulates over a lifetime, improving their function and their longevity. Pioneering Centrophenoxine researcher Imre Zs Nagy uses our Cent Pro, so if you want the experts choice you need our Centrophenoxine.

A-Z INGREDIENT LIST The following list is intended to highlight the key ingredients in some products and cross reference them to the most relevant product brand names. Note: Those products with the same name as the ingredients are not shown here as they are within the A-Z product list.

If you want this-

look for:

5-hydroxy-tryptophan

5HTP

Bioflavonoids

Wobenzym®

Acetyl-L-Carnitine (ALC)

ATP-Boost™, Vigor-Pro2™

Blueberry extracts

Andro-Pro™

Adenosine triphosphate (ATP)

ATP-Boost™

Borate

Andro-Pro™, Can-C™

AGE (advanced glycated end-product inhibitors)

ACF228™, aminoguanidine, Can-C™ Plus, carnosine, metformin, pyridoxamine

Boron

Andro-Pro™

Bromelain

Digestif®, Wobenzym®

Buxamin (GABOB)

Gamalate®, Gamibetal®

Aglomelatine

Valdoxan®

Calcium

Bone-Pro2™

Allicin (garlic)

BCI, EDD

Carboxymethylcellulose

Can-C™

Alpha lipoic acid (includes R-lipoic acid)

ATP-Boost™, Mito-Pro2™

Catalase

ACF228™

Aminexil

Dercos®

Chelation agents

Carnosine, centrophenoxine, EDTA, zeolite

Amino acids (includes di-peptides)

5HTP, ACF228™, ATPBoost™, carnosine,

Choline

Centrophenoxine

Chromium polynicotinate

ACF228™

Citrulline

Neo40®

Co-dergocrine mesilate

Hydergine®

L-tryptophan, Mito-Pro2™ Aminohydroxybutyric acid (GABOB)

Gamalate®, Gamibetal®

Aminosyn

Hair-Pro™

Coenzyme Q10

CoQ10, Mito-Pro2™

Amygdalin

Laetrile

Cortisol (cortisone)

Anti-biotics

Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline

Fludrocortisone, hydrocortisone

Cranberry extracts

Andro-Pro™

Creatine

Mito-Pro2™

Cresote bush

ACF228®, Digestif®

Cycloastragenol

TA65®

Cyclodextrin

CoQ10-SR™, Curcumin-SR™, resveratrol

Anti-depressants

Lithium, milnacipran, moclobemide, reboxetine, Stablon®, Valdoxan®, venlafaxine

Anti-oxidants

See free radical scavengers

Arimidex®

Anastrozole

Dehydroepiandrosterone

DHEA

Astragalus extracts

TA65®

Detox

DIM-Pro2™, EDTA, zeolite

Azilect®

Rasagiline

PEO-Pro™

Benzoic acid

Gerovital®

DHA (docosahexaenoic acid)

Beta blocker

Propranolol

Diapid®

Vasopressin

Beta alistine

Carnosine, ACF228®, Can-C™, Can-C Plus™

Di-IndolylMethane (DIM)

ACF228™, DIM-Pro2™

Beta glucan

BG-Cream™

bFGF

Hair-Pro™

BHT (butylhydroxytoluene)

ACF228™, BHT-Pro™

DMAE (dimethylaminoeth- Centrophenoxine anol) DMSA (dimercaptosuccinic ACF228™, DMSA-Pro™ acid) DMSO (Dimethyl sulfoxide) Laetrile

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

D-pantethine

Can-C Plus™

Dr. Dean’s recommended products

Acarbose, centrophenoxine, CurcuminSR™, Hydergine®, metformin, piracetam, Xan-Pro™

Dr. Pierpaoli’s recommended products

Melatonin, TRH

Dr. Wright’s recommended products

DHEA, Esnatri™, progesterone

Ebixa®

Memantine

EDTA (ethylene diamine tetraacetic acid)

EDTA

Eldepryl®

Deprenyl

Electrolytes

Volt-Pro™

Enzymes

Boluoke®, Wobenzym®

EPA (eicosapentaenoic acid)

PEO-Pro™

Ergoloid mesylate

Hydergine®, nicergoline

Synthetic: Desmopressin, Eutirox® thyroid, fludrocortisone, hydrocortisone, T3-Pro™ Supporting agents: DIMPro2™, GHRP2, GHRP6, peptide bioregulators, SAMe, sermorelin HRT (hormone replacement therapy for women)

DHEA, Esnatri™, melatonin, progesterone

Hyaluronic acid (hyaluronan)

Hair-Pro™, Novisyn®

IGF-1 (insulin like growth factor one)

Hair-Pro™

Indol-3-Carbinol (I3C)

DIM

Injectable products

Estrogens (estradiol, estriol, Esnatri™ estrone)

Cerebrolysin®, Cromatonbic® (B12), Gerovital®

Inter-ear products

Aldo-Spray™

Florinef®

Fludrocortisone

Inter-nasal products

Folic acid (folate)

ACF228™, DIM-Pro2™§

Free radical scavengers

ACF228™, ATP-Boost™, BioEn’R-Gy C®, glutathione, idebenone, melatonin, Mito-Pro2™, pyritinol

Desmopressin, MSH, oxytocin, GHRP6 (Releasing-Pro™), vasopressin, Vielight® laser

Iodide/ Iodine

ACF228™, BCI, Iodine-Pro™

Ixel®

Milnacipran

Ketoconazole

Nizoral® Mito-Pro2™

Fructoborate

Andro-Pro™

L-arginine

GABA (gamma-aminohydroxybutyric acid)

Gamalate®, picamilone

L-carnitine

Mito-Pro2™

L-carnosine

GABOB

Gamalate®, Gamibetal®

Carnosine, ACF228®, Can-C™, Can-C Plus™

GHRP6

Releasing-Pro™

L-citrulline

Neo40®

L-histidine

Can-C Plus™

Ginseng

Youth Gems®

Licorice

Digestif®

Glucophage®

Metformin

ATP-Boost™, Mito-Pro2™

Glutathione

ACF228®

Lipoic acid (includes R-lipoic acid) L-methione

ACF228™, Can-C Plus™

Glycerine (glycerin)

Can-C™

Lucidril®

Centrophenoxine

Glycosides

BEC5 Curaderm®

Lumbrokinase

Boluoke®

Hawthorne Berry (crataegus)

Neo40®

Magnesium

HGH (human growth hormone/ somatropin)

GABOB, GHRP2, GHRP6, sermorelin

Andro-Pro™, Bone-Pro2™, Digestif®, Gamalate®, Magnesium-Pro™, Mito-Pro2™

Manganese

Mito-Pro2™

Hormones (includes Bio-identical: Aldosterone, hormonal support supple- Esnatri™, melatonin, MSH, ments) oxytocin, pregnenolone, progesterone, TRH

Natural (animal): Armour® thyroid, ERFA® thyroid, Nature® thyroid, thymus, vasopressin

Mastic

Digestif®

Meclofenoxane

Centrophenoxine

Melanocyte stimulating hormone

MSH

Milk protein

Bone-Pro2™

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Minerals (general)

Min-Mouth™ (mouthwash), Volt-Pro™

S-Adenosyl-L-Methionine

SAMe

Minoxidil

Saw palmetto (Serena Repens)

MinSaw™, Prostate-Pro2™

MinSaw™

N-acetylcarnosine

Can-C™

Selenium

N-acetylcysteine

ACF228™, Can-C™ Plus

Namenda®

Memantine

ACF228™, DIM-Pro2™, MZS™, Prostate-Pro2™, Selenium-Pro™, Thym-Uvocal®

Neurontin®

Gabapentin

Seligiline

Deprenyl

Nettle root extract

Prostate-Pro2™

Silicone/ Silica

Wobenzym®

Niacin (nicotinate, niacinamide, vitamin B3)

Picamilone, Xan-Pro™

Solasodine glycosides

BEC5 Curaderm®

Sublingual products

Oxytocin, sermorelin

Thiocynates

1st Line™

Thyroids

Natural brands: Armour®, ERFA®, West® (Nature®)

Nicotinamide adenine dinucleotide

NADH, PQQ

Nootropil®/ Nootropyl®

Piracetam

Nordihydroguaiaretic acid (NDGA)

ACF228™, Digestif®

Synthetic brands: Eutirox® (T4), T3-Pro® (T3)

Omega 3 (DHA)

PEO-Pro™

Omega 6 (linoleic acid, GLA)

PEO-Pro™

Supporting agents: Peptide bioregulator (Thyreogen®)

Omega 9 (oleic acid)

PEO-Pro™

Thyrotropin releasing hormone

TRH

Oxythiocynate (OCSN)

1st Line™

Tribulus terrestris

Andro-Pro™

Parent Essential Oils (PEO)

PEO-Pro™

Trypsin

Wobenzym®

PABA (para-aminobenzoic acid)

Gerovital®

TRX

Hair-Pro™

Pancreatin

Wobenzym®

Turmeric

Curcumin

Panthenol (pantothenic acid)

Mito-Pro2™

Papain

Wobenzym®

Peptides

Cerebrolysin®, GHRP2, GHRP6, peptide bioregulators, sermorelin, TRH, Youth Gems®

Pimagedine

Aminoguanidine

Pomegranate extracts

Andro-Pro™

Potassium

Gerovital®, Potassium-Pro™

VEGF

Hair-Pro™

Vincamine

Anacervix®

Vitamin A (beta carotene, palmitate)

BCI

Vinpocetine

Vin-Pro™

Vitamin B1 (thiamine)

Mito-Pro2™

Vitamin B2 (riboflavin)

Mito-Pro2™

Vitamin B3 (niacin, niacinamide)

Mito-Pro2™

Vitamin B6 (pyridoxal, pyridoxine)

ACF228™, Andro-Pro™, DIM-Pro2™, Gamalate®, pyridoxamine

Vitamin B12 (cobalamin)

DIM-Pro2™, Neo40®

Vitamin B17

Laetrile

Prasterone

DHEA

Propionyl-L-carnitine

Vigor-Pro2™

Probiotics

Digestif®, Symprove®

Procaine (Novocain®)

Gerovital®

Pygeum africanum

Prostate-Pro2™

Vitamin D3 (cholecalciferol)

Bone-Pro2™, D3, Prostate-Pro2™

Pyroloquinoline quinone

PQQ

Vitamin C (ascorbic acid)

Digestif®, MinSaw™, Neo40®

Quercetin

Digestif®

Vitamin E (tocopherols)

Ubiquinol

CoQ10

Can-C Plus™, DIM-Pro2™, Prostate-Pro2™

Ubiquinone

CoQ10

Bone-Pro2™

Red clover herb extracts

Prostate-Pro2™

Vitamin K2 (menatretrenone)

Reminyl®

Galantamine

Water based

Symprove®

Retinolic acid (tretinoin)

Retin-A®

Zeolite

ACZ®

Ribonucleic acids (RNA)

Cerebrolysin®, NeyDent® toothpaste

Zinc

Rutin

Wobenzym®

Andro-Pro™, Can-C Plus™, Mito-Pro2™, MZS™, Thym-Uvocal®, Zinc-Pro™

Salicylic acid

BEC5 Curaderm® www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

TESTIMONIALS NICE COMMENTS FROM NICE PEOPLE

Dr. Aubrey De Grey “IAS has shown great vision and

Garry Gordon, MD, DO, MD (H)

Jonathan Wright, M.D.

“I am a 77 year old Physician

“Every adult has the right to take

Nicholas Perricone, M.D. “IAS is an outstanding resource

leadership, as an organisation

who has practiced medicine

care of his or her own personal

focused mainly on the

for nearly half a century.

health as he or she chooses.

date news and information

provision of contemporary

My antiaging research has

In the 20th and 21st centuries,

on healthy aging. They also

medical interventions against

permitted me to overcome

this universal human right

offer products of the highest

aging, and in also supporting

serious health problems.

has been nearly obliterated

integrity and efficacy. In fact,

the SENS Foundation’s efforts

Everyone can do this, but it

by an ocean of nanny-state

IAS is the world’s greatest

to hasten the development of

requires specialized knowledge

regulation and deliberate

source (often the only source)

much more powerful future

and the highest quality

suppression of information by

for the most cutting edge and

interventions.”

products. IAS is a vital link in

bureaucracies, with hidden

advanced nutrients to ensure

my antiaging program because

and not-so-hidden agendas.

optimum health span and

they continually provide both

International Antiaging

maximum life span.”

accurate information AND the

Systems is a beacon of useful

high quality products we all

health care information and

require, if we are to achieve

a literal island of freedom of

our maximum intended

health care product choice in

useful lifespan.”

our otherwise un-free health

for the finest, most up-to-

care world.”

Thierry Hertoghe, M.D.

“IAS is one of the pioneering societies in antiaging medicine...” Thierry Hertoghe, M.D.

“IAS has a history of making throughout the world crucial, but difficultly accessible medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has

See all professional and public testimonials at: www.antiaging-systems.com/content/11-testimonials

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helped this new medical specialty move forward.”

PAYMENT OPTIONS ACROSS THE IA S WEBS ITES…

PAYMENT OPTIONS AND CONTACT DETAILS The IAS Group offers a wide range of payment options to make the completion of your order as easy as possible. For example, at www.antiaging-systems.com you can: · · · ·

Pay by VISA credit card Use an electronic check via CHECK2PAY (US banks only) Pay via Bank Wire Pay by Debit Way (EU banks only)

In addition, at www.antiaging-nutrition.com, www.iasjapan.com, www.antiaging-peptides.com and www.antiaging-nootropics.com you can use PayPal which also includes Visa, MasterCard, Debit Cards and American Express credit cards.

To discover more on how to use any of these payment methods please contact us, or visit this page for details: www.antiaging-systems.com/content/10-faqs

WEBSITES www.antiaging-systems.com (all of our products in one place; English language) www.antiaging-nutrition.com (our nutritional products; English language) www.antiaging-nootropics.com (our smart drugs and nutrients; English language) www.antiaging-peptides.com (our peptide bioregulators; English language) www.IASjapan.com (our nutritional products; Japanese language)

EMAIL ias@antiaging-systems.com (English language) iasjapan@antiaging-systems.com (Japanese language)

PHONE USA: 1-866-800-4677 (orders only) Japan: 050-553-29606 UK: 0208-123-2106 ROW: +44-208-123-2106

1-415-992-5563 (enquiries)

Please note: Our customer care team is available from 9am till 6pm GMT Monday-Friday. Outside of these times your call will be handled by our out-of-hours answering service or go to voicemail.

MAIL Unfortunately personal checks and money orders cannot be accepted at this time. Please contact our customer service team if you need any assistance in placing your order.

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

• Acarbose ﬁghts diabetes, weight gain and aging! • Acarbose helps to prevent the breakdown of carbohydrates in the stomach into sugars. • Acarbose is used to help diabetics by preventing ‘sugar spikes’ and it can also be a useful adjunct for weight loss too, since slowing and preventing carbohydrate absorption aids dieting.

Acarbose (Glucobay ) ®

30 x 100mg Chewable Tablets - $22.00 (Usually $27.49 - Aging Matters Special*: Save $5.49 per pack!) (*Oﬀer ends June 30th 2015)

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

Acarbose