Aging Matters, Issue 4, 2016

No 4, 2016

US $8.00/ EU €6.00/ GB £5.00 where sold

WHY DO

WOMEN The Peptide Human Life-Extension Trial Some Antioxidants Extend Lifespan

LIVE LONGER?

In-Depth Product Guides The in-house magazine for the International Antiaging Society Private Members Club.

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WELCOME In previous issues on the topic of longevity, we have delved deep into important subjects such as melatonin, circadian rhythms and blood and arterial conditions, plus several of the significant theories of aging. In this issue, we want to present some different items of interest, in order to help raise awareness of lesser known topics.

Such studies, unknown even by many in the antiaging fraternity, are those that have been conducted on factory workers within Russia, utilising the pineal, thymus and some of the other peptide bioregulators. Since it is rare that such studies are conducted on humans, we see them as having particular and important relevance.

Plus, why do women live longer than men? Dr. Marios Kyriazis attempts to answer that very question.

Surely nearly everyone would agree that life-extension is a fascinating subject, especially if we end up understanding and controlling the keys to healthy longevity itself. Therefore we trust that you enjoy what this issue of the Aging Matters™ magazine has to offer.

Without trying to sound too much like Spock from Star Trek, we hope you: “live long and prosper.”

Phil M

CONTENTS WELCOME Thanks for finding the time

FOREFRONT Interesting items in the news

Ward Dean, M.D.

Editor, Aging Matters™ Magazine

Medical Director

4

THE PEPTIDE BIOREGUL ATOR LIFE EX TENSION TRIAL Did you know about it? 6

WHY DO WOMEN LIVE LONGER THAN MEN? Dr. Kyriazis spills the beans 14

ANTIOXIDANTS EX TEND LIFESPAN But not all antioxidants are the same! 20

A-Z PRODUCT LISTING AND PRICES Find everything in-stock here

Phil Micans, MS, PharmB

3

Centre Page Pull-Out

FEATURED PRODUCTS Best sellers and new items

27

CROSS -REFERENCE LISTS Find what you need here

TOMORROW’S TREATMENTS TODAY

™

IAS is dedicated to helping you access the world’s latest commercially available supplements- to give you and your family real choices in health and wellness. IAS promises you:

41

TESTIMONIALS & EXPLANATIONS Nice comments from nice people

50

CONTACT DETAILS Get in touch with IAS today

51

• Quality: We stock the best quality products because the right materials and formulas give you the best possible results.

• Brands: We carry original brands - i.e. the same ones used by top health professionals.

• Choice: We have the largest range of medicines, hormones and supplements. If you are looking for things that use words like bioidentical, efficacy and synergy then you’ve come to the right place.

• Pricing: Our prices are competitive and we regularly have special offers to help you save money on the things that are important to you and your family.

• Support: Our friendly and professional customer care team are on-hand to help you. We can be bothered!

• Professional: We work alongside the leaders in the field and we review the latest research to ensure that everything is up-to-date. After all, if we are informed then so are you.

• Sponsorship: All over the world you will find IAS supporting, sponsoring, exhibiting and lecturing at key venues. You can meet us in person and see what we believe in.

Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members (and therefore is not intended for the public).

It focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the main focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual.

Copyright 2016: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents.

Disclaimer: All educational information is offered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. All prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice.

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3

FOREFRONT THE THINGS YOU NEED TO K NOW FROM THI S MONTH’ S NE WS

Zika Virus:

too risky to be in Brazil?

With the Summer Olympics in Rio de Janeiro fast approaching, there have been a few sport stars pulling out over questions of just how risky it is to be in Brazil at this time.

The Zika virus is spread to humans via the bite of an infected Aedes mosquito.

It can also be passed from human to human through unprotected sex with an infected man, or from a pregnant woman to her fetus.

The mosquitos that carry the Zika virus are particularly aggressive during the daytime.

The symptoms of zika virus can be quite minimal, in fact many people who have the virus may not show any symptoms at all. Potential symptoms are a fever, rash, joint pain, or red eyes; but sore muscles and headaches are also signs. It is also believed that once a person has been infected with zika virus they will be immune to it in the future.

The main concern for people at the present time is the high risk of the virus causing microcephaly during pregnancy. Microcephaly is when a child is born with abnormal smallness of the

4

head, a congenital condition associated with incomplete brain development. There have been reports of other complications including eye and ear defects, and impaired growth.

There is no specific treatment for the Zika virus, it is simply advised to treat the symptoms by drinking plenty of fluids, and rest.

Medication to reduce any fever or pain is also advised. It is not recommended to take any aspirin or non-steroidal antiinflammatory drugs.

With conflicting, or not very clear advice, from many medical professionals, it does leave a big question for those traveling in this area in the coming months.

“Microcephaly is when a child is born with abnormal smallness of the head, a congenital condition associated with incomplete brain development.”

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FOREFRONT THE THINGS YOU NEED TO K NOW FROM THI S MONTH’ S NE WS

‘Second skin’ can make you look ten years younger test results, it reduces wrinkles It is very difficult to create a material that looks like skin and and eye bags … and can make behaves in the same way. Now, you look ten years younger in a flash! It does this by forming after many years of research, an invisible film over the skin scientists have developed XPL: that protects it and makes it an innovative film that mimics look smoother and firmer. This natural skin to perfection. “second skin” – which is flexible At first, the new material may and comfortable to wear only be used for medical keeps moisture in while still purposes: treatments for allowing the skin to breathe. It dermatitis, wound dressings, can be worn all day without delivery of medicines via causing irritation. the skin and perhaps as a More research is needed sunscreen. before the product is But there is a lot of excitement approved for cosmetic about other possible purposes, but that day may be applications, and one in coming soon. particular. XPL has been called “a face-lift in a jar”. According to

Are you getting enough sleep?

Sleep is more important than you might think. Eight hours of sleep is supposed to be the norm, but research concludes that this varies widely with age. Lack of sleep has been linked to a wide range of health problems including cancer, heart disease and type-2 diabetes. Shift workers may be especially vulnerable.

If you find you are tossing and turning and can’t get to sleep, you may be able to improve

matters in the following ways: • Minimize your exposure to light at bedtime, especially the “blue” light produced by computerized gadgets (although some devices now compensate for this). The built-in body clock that tells us when we need to sleep is disrupted by bright light • Avoid alcohol with dinner and don’t have caffeinated drinks after 2 o’clock in the afternoon

• Try not to have a large meal too close to bedtime What if you can’t sleep, or wake up after just a short time asleep? Don’t worry about it, as that could make things worse. Try reading a book for a while… or get up and do some sort of activity that distracts your mind, such as a puzzle (but not on your computer!) and then try getting to sleep again. It will probably work!

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5

PEPTIDE BIOREGULATORS PROMOTE ACTIVE AND FUNCTIONAL LONGEVITY

By Leslie J. Farer

According to a 2012 United Nations estimate, over 300,000 people worldwide had reached their 100th birthday to become centenarians. Of these, a tiny percentage will go on to become supercentenarians, (110 years old and above) who characteristically experience relatively good health and an absence of age‑related diseases until shortly before death at a very advanced age.

These enduring individuals are portions of genes’ DNA to living proof that humans have regulate and initiate processes the potential to live to 100, 110, that synthesize proteins, or 120 years old, even beyond. regenerate tissue, and restore functions of organs that What factors promote their have undergone age-related exceptional longevity and damage. why does 99.996 percent of As a result of their the rest of the population rejuvenating properties, age more quickly, lose peptide bioregulators functionality, develop have been classified as diseases and die decades “geroprotectors” (literally, younger? This question is at “aging protectors,” i.e., drugs the core of medical research or substances that target the aimed at determining the root causes of aging and biological and genetic factors degenerative diseases) and that result in age-related we’ll explore in this article deterioration and developing their impressive longevityeffective strategies to promoting potential: in counter them. Currently the multiple studies, long-term therapeutic arsenal includes treatment with various calorie restriction (and peptides has been shown calorie restriction mimetics), to increase the lifespans of antioxidants, glycation animals by up to 40 percent inhibitors, telomerase and significantly decrease activators, stem cells and substances such as melatonin, mortality rates in aging humans while enhancing carnosine, metformin, physiological function, deprenyl and some others. physical performance and To add to this list, emerging overall health. research over the past four decades has uncovered the The Aging Process powerful life-extending Aging, or senescence, is a potential of peptide complex biological process bioregulators. These and trying to describe it biologically active short invariably involves words chains of amino acids have with negative connotations: the ability to repair genetic alterations occurring with decline, decay, degeneration, death etc. One (very age: they directly bind with

unpleasant) definition of aging is “the collection of changes that render human beings progressively more likely to die.” (1) A more detailed description is “a progressive loss of physiological integrity, leading to impaired function and increased vulnerability.” (2) So, to combine these, we can say that aging is associated with accumulating physiological impairments that lead to decreased function and increased risk of age-related diseases, (i.e., cancer, diabetes, cardiovascular disorders, neurodegenerative diseases, etc.) and of course mortality.

One of the lead researchers on peptide bioregulators and the genetic mechanisms of aging, Professor Vladimir Khavinson, (Director of the St. Petersburg Institute of Bioregulation and Gerontology, among other scientific positions), takes the definition a step further with this graphic description of aging which he describes

as: “the gradual involution of tissues and development of organism malfunctioning [that] appears at end of the reproductive period and becomes more pronounced with age.” (3) The term involution denotes the shriveling, or shrinking of organs, or tissues that occurs over time due to reasons we’ll examine in the next section.

Aging results in disturbances of the major regulatory systems in the body, (nervous, endocrine, and immune systems) and according to Khavinson, the atrophy of the thymus (immune system) and the pineal gland (neuroendocrine system) are the major manifestations of age-related decline. (4) Studies outlined below demonstrate that restoration of these and other organs results in dramatic improvement in physiological function and lengthening of lifespan in animals and humans.

Professor Vladimir Khavinson is the former President of the European region of the International Association of Gerontology and Geriatrics; the main gerontologist of the Government of St. Petersburg and Director of the St. Petersburg Institute of Bioregulation and Gerontology.

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Figure 1: The interaction of a peptide bioregulator (as shown in red) with DNA initiates protein synthesis.

decreased protein synthesis, leading to structural and functional deterioration of various organs, resulting in aging and age-related diseases (the “peptide theory of aging”). (4,5,7,8,9,11) Khavinson’s breakthrough discovery is that this degenerative cascade of aging can be reversed.

Peptide-Induced Regenerative and Longevity Effects in Animals When administered to animals (and later to humans) 80

Figure 2 (right,top): The effect of the thymus peptide bioregulator on metabolism in patients aged 60-74 years.

Figure 3 (right, lower): The pineal peptide bioregulator effect on melatonin production in monkeys of different age.

8

Khavinson found that the peptide extracts he had isolated produced restorative effects in cells and tissues of the organ from which the particular peptide had originally been derived. (5) For instance, thymic peptides stimulated immunity (4,8) and pineal peptides induced the pineal gland to manufacture melatonin. (4,8, see figures 2 and 3 respectively).

Trials using peptide preparations obtained from other organs, (i.e., retina, prostate, cerebral cortex, adrenal gland, liver, etc.) have

%

*

70

*

*

75

73

60 50

*

40

74

30

46

20 10

12

0

Subjective improvement

14 Carbohydrate metabolism normalization

16

8

Normalization of the liver detoxification function

Increase in the density of the osseus tissue

Patients aged 60-74, administered with polyvitamins Patients aged 60-74, administered with thymus preparation

60 ** pg/ml

organ in which they are active (hence the designation “peptide bioregulator”).

Each specific peptide interacts with specific sections of Previous research dating DNA, transferring information from as early as the 1960’s encoded in its amino (initiated by Professor Vladimir acid sequence to regulate Dilman of the same St. particular genes in a particular Petersburg based institute), tissue. (4,5) Activation of these had shown that small, low genes, (i.e., gene expression) molecular weight regulatory stimulates protein synthesis, peptides are involved the (4,6,7) the manufacture of genetic transfer of biological proteins according to the information that leads to the encoded genetic information, synthesis of proteins. (3) Using a complex process this finding as the foundation indispensable to life. (See for his research, and with the figure 1) goal of regenerating tissue to Depending on the specific restore the functions of agegenes expressed and the damaged organs, Khavinson particular tissue involved, and his team began their protein synthesis results in work decades ago by devising the assembly of thousands, a method for the isolation and even millions, of different purification of small peptides substances necessary from extracts of various for overall physiological animal-sourced organs. (4) functioning, including enzymes, structural proteins These amino acid chains are such as collagen, hormones endogenously produced in such as melatonin and insulin, the cells of healthy tissues antibodies, hemoglobin, etc. and play a regulatory role at Over time, however, changes the molecular and cellular in gene expression and levels that impacts the overall biochemical and physiological impairments in endogenous peptide production result in functioning of the particular

40 20

*

0 6-8 years Placebo

20-26 years Peptide Ala-Glu-Asp-Gly

* p<0.01 as compared to the control group of young animals (placebo) ** p<0.001 as compared to the control group of old animals (placebo)

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* p<0.05 as compared to polyvitamins administration

Peptide Bioregulators Initiate a Crucial Process Altered by Age: Protein Synthesis

6-8 years

nmole/l 1400

Figure 4: The adrenal peptide bioregulator effect on cortisol production in monkeys of different age, (in the morning and in the evening). Notice how the treated older animals’ cortisol production morning and evening now looks much closer to that of the young non-treated animals.

1200

1200

1000

1000

800

800

600

600

400

400

200

200

0

Placebo

0

Ala-Glu-Asp-Gly - 9:00 a.m.

all demonstrated beneficial effects on the condition and function of the respective gland, organ or tissues. (8) Amazingly, peptides isolated from organs of young animals were shown to trigger protein synthesis and restore the functions of aging, deteriorating organs in old animals. (4) For example, pineal peptides improved several aspects of age-related endocrine dysfunction by restoring reproductive function and fertility in old female rats that had undergone a process equivalent to menopause in women; (4) and increasing nightly melatonin production, normalizing daily cortisol secretion, decreasing glucose and insulin levels in aging rhesus monkeys. (11,12, see figure 4).

The results of Khavinson’s longevity experiments in

With respect to the control (0)

40

animals were equally (if not more) compelling. In numerous studies over the course of three decades, longterm treatment with peptides isolated from thymus and pineal gland increased the average life span in drosophila (fruit flies), rats and mice by 20 to 40 percent (with some animals reaching their species maximum life span), slowed changes in biomarkers of aging and considerably suppressed tumor development. (4, see figure 5) These results have enormous implications for preventing cancer, retarding aging and extending life span in humans.

% * *

30

*

20-26 years

nmole/l 1400

Another Peptide-Mediated Longevity Mechanism: Telomerase Activation Besides stimulation of protein synthesis, Khavinson found that another genetic mechanism was operating to account for these impressive longevity results.

In an experiment on cultured human lung fibroblasts (connective tissue cells), the addition of pineal peptide activated the telomerase gene and lengthened telomeres.

Aging is associated with a decrease in the ability of cells to divide, (necessary for the construction and repair of tissues) due to the progressive shortening of structures called telomeres.

Telomeres are the protective “caps” at the ends of chromosomes and telomerase is an enzyme that adds repetitive DNA sequences to these “caps” each time a cell divides. (During cell division, telomeric portions of DNA are lost due to an inherent problem of incomplete

*

Placebo

Ala-Glu-Asp-Gly

- 9:00 p.m.

end-replication. Telomerase ensures the complete copying of DNA repeats so that telomeres can maintain their length.) Most of the body’s cells, (excluding reproductive cells) can divide only a finite number of times, the socalled Hayflick limit, according to a programmed genetic clock that results in decreased telomerase production with age, leading to progressive shortening of telomeres, until cell division stops altogether.

This process, known as replicative senescence, ultimately leads to aging and age-related diseases.

Khavinson found that the addition of pineal peptide to cultured human cells activated the telomerase gene to synthesize telomerase, resulting in lengthened telomeres and an increased number of cell divisions, overcoming the Hayflick limit. (4,13,14) This finding undoubtedly contributes to the extension of life span documented in the animal experiments.

20

10

0 Drosophilia melanogaster

Mice

Rats

* p<0.05 as compared to the control

Figure 5: The increase in the average lifespan up to the specific limit after peptide preparations application, (mean results after 15 experiments) on fruit flies, mice and rats- all showing very significant increases in longevity over the controls.

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Telomere length (b.p.)

Age, years

Investigation

Peptide Preparations Epithalamin

60-65 75-80

Epitalon®

Endoluten®

Initial value

9,32±0,82 (n=25)

9,61±0,93 (n=19)

9,43±1,12 (n=21)

After treatment

10,83 ± 1,12*

10,72 ± 1,21*

10,62 ± 1,32*

Initial value

7,33±0,81 (n=21)

7,51±0,91 (n=17)

7,63±0,98 (n=18)

After treatment

8,73 ± 0,78*

8,91 ± 1,11*

8,66 ± 1,21*

* - p< 0.05 as compared to initial valuet

With such remarkable results in cell culture and animal studies, Khavinson’s interest turned toward testing the peptides’ telomere lengthening effects in humans, those results are shown in figure 6.

As can be seen, in the study of 121 patients aged 60-80 years old, the use of the pineal peptide bioregulator produced an average increase of telomere length between 11% and 19%.

Biologic Reserve - the Capacity to go the Distance According to Khavinson, and as his experiments in rats and mice demonstrate, the potential or maximum animal lifespan is approximately 30 to 40 percent higher than the actual average lifespan (4) for a particular species, so does this finding extend to humans as well? Well, for example, we know that humans can live to between 100 and 120 years old, (with the record for human longevity set at 122 years by Jeanne Calment of

70-75 years

30-45 years

France), which is an extra 30 to 40 years above the average human lifespan of 80 years.

This capacity for three to four additional decades of life is what Khavinson calls the “biologic reserve.” (3) (See Figure 7.) Omitting factors such as predation, plagues, famine, wars, homicide, etc., why are animals and humans not reaching their species maximum lifespans? It is surmised it is because, that largely aging is a genetically determined and mediated process with inherent limitations.

For example, the telomere shortening and replicative senescence that we just discussed is one glitch in the genetic program of aging. Another is altered gene expression, the decline of endogenous peptide production and ergo impaired protein synthesis. As we saw earlier, tissue-specific peptides regulate the activity of particular genes in order to manufacture proteins: each peptide binds its amino acid Disturbances: - biorhythms - water - food Changes in the expression and structure of genes

Summary sequence to a nucleotide sequence on a gene’s DNA Delivery of the appropriate (see figure 2) and sets into peptides can ameliorate or motion the transcriptional reverse these degenerative machinery that ultimately processes, essentially results in the synthesis of “restocking” the biological one of thousands of crucial reserve. We can think proteins, (see figure 8). of biological reserve Any flaw in this finely as “supplementary life orchestrated and complex span potential” or the set of steps can lead to difference between the the downward spiral of maximum number of organ deterioration, disease years one could live under development and aging (i.e., optimal physiological a “biological deficit”) − one conditions when the genetic of the major reasons that mechanisms of aging are animals and humans fall short slowed or reversed, such of reaching their potential as with the use of peptide maximum longevity. bioregulators and the average It should be mentioned life span for the species when that built-in genetic the aging program progresses malfunctions are not the unabated, which is shorter, at only culprits − negative least in part due to the impact environmental factors such of the above mentioned as stressors (external and limitations of the genetic internal), radiation, pollution, aging program, as well as pesticides and other toxins, negative environmental inadequate nutrition, etc., factors. can also affect biological Are there any examples mechanisms and hinder the relative to humans? Yes there regulation of protein synthesis, are! leading to accelerated or premature aging.

Figure 7: The average vs. the potential maximum human life span and the concept of the ‘biological reserve.’

Adverse factors: - stress - environmental factors - radiation The average human lifespan nowadays (premature aging) Biological reserve of human life

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Figure 6: These experiments show that all versions of the pineal peptide extend telomere length.

These are blood samples taken from patients from the age of 60 to 80. Data on file: Laboratory of Biogerontology of the St. Petersburg Institute of Bioregulation and Gerontology.

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Transcriptional mediator (protein complex)

Duplication Cell division

2nd signal Transcription

DNA Synthesis

RNA

1st signal

Activations of genes

PEPTIDES

Translation Ribosomes

Degradation

3rd signal

PROTEINS

Figure 8: The role of peptide bioregulators in the cycle of DNA, RNA and protein biosynthesis.

Metabolism

Human Studies with Peptide Bioregulators After the experiments on drosophila, rats, mice and monkeys, the obvious and immediate question was whether the impressive results could be duplicated in humans. A slew of studies, many of them large-scale, were performed in the Soviet Union to find out, specifically with regard to improving physiological function, preventing and ameliorating diseases and enhancing longevity.

In one of these trials, seniors aged 60 to 74 years were treated with pineal peptide for 12 years, and older seniors aged 75 to 89 were treated with both pineal and thymus peptides for six years. Control groups for each age category received only vitamins.

In this and other human trials, Khavinson calculated mortality rates, (the number of deaths in each of the control and treatment groups over a period of time) as an inverse indicator of longevity (i.e., a decreased mortality rate is equivalent to an increased survival rate, indicating that more people are staying alive longer). Unlike the animal experiments in which the lifespans of short-lived species could be easily measured, obviously, it was not practical or possible to conduct human studies over several decades to determine the ages at death of the longest-living people, so instead mortality rates were used.

The results showed that, compared to controls, those in the combined peptide treatment group

demonstrated improved brain, immune, endocrine and cardiovascular function, as well as increased bone density, more youthful nocturnal melatonin levels and, as expected, lowered mortality rates, (see figure 9).

On this last point, in the 60 to 74 year old group receiving the pineal peptide bioregulator, the mortality rate was about half (22 percent) that of the control group (44 percent) over the course of 12 years.

Meanwhile, the older seniors aged 75 to 89 years receiving both thymus and pineal gland preparations for six years cut their mortality rate even further, to 33 percent, compared to 82 percent in their control group â&#x20AC;&#x201D; a significant and remarkable improvement, especially in

this older age group. (4) Khavinson also conducted several studies on the effects of peptide bioregulators on industrial workers in Russia who are often submitted to unsatisfactory conditions with negative health consequences, including premature aging. Some large studies were done on hundreds of employees of the automobile and electricity industries who exhibited physical improvements and protection against aging in response to treatment with various combinations of peptide bioregulators. The largest of these was on thousands of workers at Gazprom, a huge gas extraction and gas transportation company in Siberia. These employees are exposed to extreme

CHANGES IN MORBIDITY LEVELS 2.8 times

Figure 9: 450 factory workers treated with the peptide bioregulators for brain, pineal and thymus. The treated group has a 2.4 times less respiratory disease and 2.8 less times morbidity compared to 400 controls (15).

2.4 times

Control group

Acute respiratory diseases

Total morbidity

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Figure 10: The effect after 1-year of peptide bioregulators on the rate of aging on 300 factory workers aged 40-55 years whom were under the influence of harmful factors, (compared to 200 controls who took multivitamins). Biological age measurements were improved in all the peptide bioregulator treated individuals.

All of these positive health outcomes over the course of the one year observation period reflect the geroprotective effects of peptide bioregulators in suppressing environmentallyinduced premature aging and increasing biologic reserve in the thousands of workers studied.

atrophy, loss of function, disease development, and shortened life span.

2. Through the regulation of particular genes in particular tissues, peptides have the ability to reinitiate a process stalled by age, namely protein synthesis, leading to the repair and rebuilding of damaged tissues and organs and restoration of their main functions.

3. When used in combination, their rejuvenating effects are not just organ-specific but system-wide, resulting in significant increases in life span in animals and decreased mortality rates in humans, along with lowered disease incidence, reduced

Aging rate index = biologic age/due biologic age

1,84

Conclusion We’ve covered a lot of territory in this article, so let’s recap the main points.

1. Biologically active tissuespecific peptides correct agerelated genetic malfunctions which would otherwise result in the typical degenerative process of aging: organ

biological age, and improved physiological function and physical performance, all of which indicate enhanced biological reserve.

4. Through the peptide regulation of aging, humans now have the potential opportunity to add two or three (or perhaps more) decades of life to perhaps achieve the longevity of centenarians, or even supercentenarians, while remaining active, functional, vibrant and healthy. The studies highlight that the two most significant peptide bioregulators to date, in this respect are those emanating from the thymus and the pineal glands.

- Initial state

- After correction with peptide bioregulators

1,80 1,76 1,72

*

1,68 0

Control

Peptide bioregulator of the brain

* - p<0.05 compared to the initial state

as opposed to chronological age) and improved quality of life. (16, see figure 10)

Aging rate index (years)

environmental and work conditions that result in increased incidence of chronic diseases, premature aging and higher than average mortality rates.

Khavinson developed the “Program of Age-Related Pathology Prevention and Professional Longevity Extension” to counter these negative effects and restore health to these workers. Over 11,000 employees, (aged 35 to 60) received six oral peptides (immune, brain, blood vessels, bronchi, liver and cartilage) for 30 days. A control group of 3,000 workers received oral multivitamins for the same duration and both groups were monitored for one year.

The results showed that the peptide bioregulator treated group cut the frequency of acute respiratory disease by more than half and the overall incidence of disease by two-thirds, compared to the control group. In addition, they demonstrated improved work performance and attendance, reduced “biological age” (a measure of mental and physical capacity,

Complex of Peptide bioregulator peptide bioregulators of the brain and of the vessels the vessels

References 1. www.senescence.info/aging_ definition.html 2. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217.

3. www.antiaging-systems.com/ articles/351-peptide-regulation-ofaging 4. Anisimov V.N., Khavinson V.Kh. Peptide bioregulation of aging: results and prospects. Biogerontology.

2010;11:139-149.

5. Khavinson V.Kh., Anisimov V.N. Peptide Regulation of Aging: 35-Year Research Experience. Bulletin of Experimental Biology and Medicine.

2009;148:94-98.

6. Khavinson V.Kh., Kuznik B.I., Ryzhak G.A. Peptide Bioregulators: A New Class

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of Geroprotectors. Message 1: Results of Experimental Studies. Advances in Gerontology. 2013;3(3):225-235.

7. Khavinson V.Kh., Lin’kova N.S., Trofimov A.V., Polyakova V.O., Sevost’yanova N.N., Kvetnoy I.M. Morphofunctional Fundamentals for Peptide Regulation of Aging. Biology Bulletin Reviews. 2011;1(4):390-394.

8. Khavinson VKh. Peptides and Ageing.

Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.

Shataeva L.K., Yakutseni P.P. Short Cell-Penetrating Peptides: A Model of Interactions with Gene Promoter Sites.

Bulletin of Experimental Biology and Medicine. 2013;154(3):403-408.

11. Goncharova N.D., Lapin B.A., Khavinson V.Kh. Age-Associated Endocrine Dysfunctions and Approaches to Their Correction. Bulletin of Experimental Biology and Medicine.

2002;134(5):417-421.

9. Khavinson V.Kh., Solov’ev A.Yu., Zhilinskii D.V., Shataeva L.K., Vanyushin B.F. Epigenetic Aspects of PeptideMediated Regulation of Aging.

Advances in Gerontology. 2012;2(4):277286.

12. Goncharova N.D., Vengerin A.A., Khavinson V.Kh., Lapin B.A. Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas.

Experimental Gerontology. 2005;40:5157.

10. Khavinson V.Kh., Tarnovskaya S.I., Linkova N.S., Pronyaeva V.E.,

13. Khavinson V.Kh., Bondarev I.E., Butyugov A.A. Epithalon Peptide

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Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bulletin of Experimental Biology and Medicine. 2003;135(6):590-592.

14. Khavinson V.Kh, Bondarev I.E, Butyugov A.A., Smirnova T.D. Peptide Promotes Overcoming of the Division Limit in Human Somatic Cell. Bulletin of Experimental Biology and Medicine.

2004;137(5):613-616.

15. Khavinson, V. Program of AgeRelated Pathology Prevention and Professional Longevity Extension among “Gazprom” Personnel.

Gerontology. 2001 July. 47(1): 453-454.

16. Bashkireva A.S., Konovalov S.S. Prevention of accelerated aging of working in harmful conditions. Moscow 2001.

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WHY DO WOMEN LIVE LONGER THAN MEN?

By Dr. Marios Kyriazis

It is a known fact that, in general, women live longer than men. All life expectancy calculations over the past years tend to show that females live several years longer compared to males, as a group (see figure 1).

Years 85

80

75

70

65 1980-82 1985-87

1990-92 1995-97 2000-02 2005-07 Males Females

Figure 1: Although life expectancy for both sexes has been rising, there is still a 5-6 year gap between male and female life expectancy.

14

It is a known fact that, in general, women live longer than men. All life expectancy calculations over the past years tend to show that females live several years longer compared to males, as a group (see figure 1).

There are several theories trying to explain this phenomenon and some concepts are better

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supported by research than others. This discussion refers to the rate of aging process in regard to gender and not to the individual perception of aging. In other words, it is about the biological mechanisms which may be causing men to age faster than women and not about how males or females may subjectively feel ‘old’.

glucose testosterone insulin IGF-1

Amino acids Fatty acids

TOR

Growth Hyper-function

Aging Diseases of aging

Life time When we look at the death rate in men, a few facts are obvious. In young men, death is usually due to accidents, (as men tend to take more risks compared to women).

In contrast, older men commonly die from agerelated degenerative diseases such as stroke, heart disease and similar.

This makes sense and reflects life in the wild: men needed to be stronger and more muscular than women, in order to be able to deal successfully with the rigours of physical life, (accidents, fighting and manual work etc.)

We know that muscle growth and testosterone production are stimulated by a specific signalling pathway, known as the mechanical (mammalian) Target of Rapamycin –mTOR. So, in young men, mTOR seems to be beneficial as it makes them better able to survive, although we also know that in older men many aging signs may be accelerated when we enhance mTOR and these signs may be reduced when we inhibit mTOR. For example, an active mTOR pathway in older men may accelerate the risk of cancer, dementia and atherosclerosis, when at the same time; any agents that inhibit mTOR also delay these

manifestations of aging. The point here is that the specific example of mTOR is indicative of ‘antagonistic pleiotropy’, when an expression of a gene or a factor may be beneficial early in life (assuring good function when young) but becomes deleterious later in life, (accelerating aging and risk of death) when strength and stamina are less relevant, following reproduction, (see figure 2).

Ed. - for more information about mTOR inhibitors please see Dr. Kyriazis article that appeared in Aging Matters™ issue 5, 2015.

In this respect, two general aims may have practical relevance in clinical situations: • Aim to enhance mTOR function in young men and • Aim to inhibit mTOR function in older men.

People who take supplements to modulate their mTOR function should be aware of this issue and act according to their age- this is why I always suggest that an expert physician should be involved in all cases of antiaging medication regimes.

Let me return to the case of testosterone. As mentioned above, testosterone improves muscle mass and strength in young men and it is upregulated by mTOR, but a

Figure 2: The relationship between testosterone, other compounds and mTOR with regards to aging vs healthy growth.

too high activity of mTOR contributes to aging (1, 2). However, the issue is complicated because we also know that testosterone increases muscle mass in frail older people too, so it can be used to improve physical function in later life (3). This is also true of other androgens which protect against cardiovascular disease and other chronic conditions (4). On balance, it seems that certain people could benefit from testosterone supplementation in later life, while others could not (5), so it is important to involve an expert practitioner in choosing suitable products and monitor the blood levels of the different hormones.

Deprenyl (selegiline) In a study, administration of deprenyl in laboratory rats resulted in an increased sperm count and high levels of testosterone (6). This aligns well with the discussion above, which may suggest that high testosterone in young life is beneficial, whereas it becomes less relevant in older life. The value of deprenyl supplementation has been shown in several experiments involving older men too (7) so it may be that deprenyl has several modulating effects: valuable both in the old and in the young, but acting through different mechanisms in the different age groups (8).

Metformin

Complex I

AMPK

NAD(P)H oxidase

mTOR

Protein synthesis

Rapamycin

Autofagy

ROS

Life extension Figure 3: A possible mechanism for the life extending effects of metformin, involving mTOR.

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15

“Many natural mechanisms ensure that prolonged or enhanced reproduction also means early aging... Therefore, it follows that shorter periods of reproduction are associated with a slowing down of aging.”

Metformin An interesting study sheds some light (and poses many questions!) with regards to the function of metformin and longevity in men. The authors found that metformin causes significantly more health benefits in women compared to men (9). The point here is that women may react differently to the same substance compared to men and the reasons for this are unknown, although it is tempting to speculate that there is a hormonal link.

In this study, the antidiabetic effects of metformin were more pronounced in women than in men. If metformin has any life prolonging effects, (see the TAME initiative) then these may be related to the gender of the patient, as well as to their age. It would be interesting to see if women treated with metformin live longer than men treated

with it. So, there is a definite interplay between age, gender, and metformin (which is also acting as an mTOR modulator- figure 3).

Longevity and reproduction We know that aging is strongly related to reproduction. Many natural mechanisms ensure that prolonged or enhanced reproduction also means early aging, (see figure 4) and the rationale of this is well explained by the ‘disposable soma’ theory (10).

Therefore, it follows that shorter periods of reproduction are associated with a slowing down of aging.

Men are able to reproduce for longer but their lifespan is reduced, whereas women, who stop reproducing by middle age, live longer. This may reflect an underlying law of nature which states that: Life must continue -

so you either: • Live a shorter life but have a lot of offspring and thus life continues (through your offspring), or • Live a longer life but have less offspring and thus life continues (through you living longer) This hypothesis is supported by the fact that eunuchs, (men without testicles) live generally longer than other normal men. In some cases up to 14-19 years longer (11).

These comments are very simplistic but they carry the general point I want to make.

If you are interested in this subject you can read articles which examine the issue in more depth (12) and my research (13).

The jogging heart Among one of the theories proposed in order to explain the gender differences in longevity is the “jogging female heart” idea – the idea

that a woman’s heart rate increases during the second half of her menstrual cycle, offering the same benefits as moderate exercise (even though the woman is not actually exercising). The result is a delayed risk of cardiovascular disease later in life and an increased overall longevity. In a relatively old paper, the authors report that endogenous estradiol can affect the heart rate and increases cardiac output by 20% during the second half of the menstrual cycle (14).

This is comparable to the physiological effects of exercise and so young, menstruating women may have an added benefit: an improved cardiovascular health without the need to exercise as much as men need to.

Trade offs in fruit flies between longevity and reproduction Trade offs in fruit flies between longevity and reproduction Homozygous methuselah mutants Homozygous normal flies

Survivorship (%)

100 80 60 40 20 0

16

0

10

20

30 40 50 Age (days)

60

Cumulative fertility (Adult progeny per female)

Females, reared at 29°C:

70

90 80 70 60 50 40 30 20 10 0

0

10

20 30 Age (days)

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40

50

Figure 4: A study of longevity and reproduction in flies: Flies in the red group live longer than those in the blue group (left graph), and also have less offspring (right graph).

Final example and conclusions One possible or speculative much dysfunction (15). This reason why women live shows that there is always a longer was recently put balance between actions: forward by researchers who when there is a benefit studied sex differences in the in one area, there is a gut of fruit flies. They found counterbalancing damage in that there are differences in another. This general concept stem cell function between has also been shown true in younger and older flies and human subjects (16). also between female and The mechanisms involved in male flies. While females are the increased longevity of resistant to intestinal damage, females give us some insights males are not, but this is into developing strategies balanced against an increased (such as a judicious use of malfunction of the gut in certain compounds) which females (see figure 5). may enable us to enhance In other words, females our changes of a longer and live longer but spend that healthier life, whether we are extra time suffering from males or females. dysfunction, whereas males live shorter lives without

Figure 5: Cells and stem cells in fruit fly intestine.

References 1. Basualto-Alarcón C, Jorquera G, Altamirano F, Jaimovich E, Estrada M. Testosterone signals through mTOR and androgen receptor to induce muscle hypertrophy. Med Sci Sports Exerc. 2013 Sep;45(9):1712-20

prophylactic use of (-)-deprenyl (Selegiline, Jumex). Current international view and conclusions 25 years after the Knoll’s proposal.

Neuropsychopharmacol Hung. 2009 Dec;11(4):217-25

2. White JP, Gao S, Puppa MJ, Sato S, Welle SL, Carson JA. Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle. Mol Cell Endocrinol. 2013 Jan 30;365(2):174-86

8. Ebadi M, et al. Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases. Curr Drug Targets. 2006 Nov;7(11):1513-29

3. Harman SM. Testosterone in older men after the Institute of Medicine Report: where do we go from here?

Climacteric. 2005 Jun;8(2):124-35

9. Schütt M, Zimmermann A, Hood R, et al. Gender-specific Effects of Treatment with Lifestyle, Metformin or Sulfonylurea on Glycemic Control and Body Weight: A German Multicenter Analysis on 9 108 Patients.

Exp Clin Endocrinol Diabetes. 2015 Nov;123(10):622-6

4. Corona G, Rastrelli G, Monami M, Guay A, Buvat J, Sforza A, Forti G, Mannucci E, Maggi M. Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study. Eur J Endocrinol.

2011;165:687–701 5. Gems D. Evolution of sexually dimorphic longevity in humans Aging (Albany NY). 2014 Feb; 6(2): 84–91 6. Mihalik J, Mašlanková J, et al. The effect of R-(-)-deprenyl administration on reproductive parameters of rat males. Eur J Pharmacol. 2015 May 5;754:148-52 7. Miklya I. Slowing the age-induced decline of brain function with

Soma hypothesis. https://figshare. com/articles/New_draft_item_ The_Indispensable_Soma_ Hypothesis/3079732 14. Eskes T, Haanen C. Why do women live longer than men?

European Journal of Obstetrics & Gynecology and Reproductive Biology. 2007;133(2):126–133 15. Regan JC, et al. Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction.

Elife. 2016 Feb 16;5. pii: e10956 16. Hubbard RE. Sex Differences in Frailty. Interdiscip Top Gerontol Geriatr. 2015;41:41-53

10. Van den Heuvel J, English S, Uller T. Disposable Soma Theory and the Evolution of Maternal Effects on Ageing. PLoS One. 2016 Jan 11;11(1):e0145544 11. Min K-J, Lee C-K, Park H-N. The lifespan of Korean eunuchs. Current Biology. 2012;22:R792–R793 12. Last C. Human evolution, life history theory, and the end of biological reproduction. Curr Aging Sci. 2014;7(1):17-24. www.ncbi.nlm.nih. gov/pubmed/24852016 13. Kyriazis M. The Indispensable

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The National Institute on Aging (NIA) announced the final results of testing from three government labs regarding the patented antioxidant nordihydroguaiaretic acid (NDGA). All three labs agreed

By Phil Micans, MS, PharmB that NDGA extended lifespan by a resounding 12% in mice (1) - see figure 1.

When some read this astounding news, they were skeptical. With a note of cynicism and doubt in their voices, they said this report

Figure 1: The survival plots for male mice treated with nordihydroguaiaretic acid (NDGA). Each symbol represents an individual mouse dying at the age indicated. The log-rank test was used to calculate p-values for differences between treated and control mice. (1)

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“During the 1980s, researchers extensively tested NDGA in humans, mice and dogs. Results indicated that NDGA extended lifespan in a variety of mammals.” was probably hyperbole and the Federal government is not to be trusted. Yet these same three government labs had also conducted lifespan studies with muchhyped anti-aging remedies, resveratrol, curcumin, green tea, oxaloacetic acid and triglyceride oil (2) and found that these five supplements did not extend lifespan in mice.

During the 1980s, researchers extensively tested NDGA in humans, mice and dogs.

Results indicated that NDGA extended lifespan in a variety of mammals. Even the US Patent and Trademark Office approved these results and granted a patent to Dr. Richard Lippman for NDGA, (no. 4,695,590) as part of his unique formula, a formula he developed to slow aging which was based on his extensive free radical research (3).

Background Study of NDGA Before Dr. Lippman was awarded a US patent on NDGA, several attorneys voiced skepticism. In firm language, they stated that every law school student knows that two types of

patents are never granted: a patent on a perpetual motion machine and a patent on a fountain-of-youth remedy.

Apparently, Dr. Lippman convinced patent examiners that his clinical human, mice and dog studies of NDGA were sufficient to warrant a patent with claims to retard human aging. These studies were also sufficient for the drug licensing authorities of Sweden and Italy to grant Dr. Lippman the rights to sell NDGA under the name ‘Aging Control Formula 228’ (ACF228®).

Interestingly, a prominent American businessman, Glenn Braswell, had heard Dr. Lippman’s story, but Mr. Braswell doubted that it was sold at the Vatican pharmacy in Rome, Italy. Consequently, when took his wife on a trip to Rome — much to his surprise he found that ACF228® was indeed sold at the Vatican pharmacy with the pope’s blessings!

ACF228® Is Based on Extensive Free Radical Research Today, we know free radicals are not antiwar activists out on bail. But when Dr. Richard

Dr. Richard Lippman at home in Hawaii

Lippman was doing research in Sweden many years ago, most people thought the term ‘free radicals’ referred to some kind of hippie politics.

No one then knew about these molecular sharks’ devastating effects on the human body and their role in aging. Indeed, only twentyfive years ago, free radical chemistry and the toxic effects of free radicals on the human body were unknown to most of the general public and even to many doctors and medical researchers.

Dr. Lippman first learned about the free radical theory of aging as an undergraduate student. When he began doing graduate research work in cell biology, he and his colleagues held conferences at

Pharmacia-Upjohn and the University of Uppsala to discuss the exciting findings of Professor Denham Harman, whose experimental work at the University of Nebraska in the 1950s showed that the life spans of mice could be extended with special antioxidant supplementation.

The press and public responded; “So what?”

However, Sweden is well known in science and engineering for its industrial and

“The Swedish Research Council financed years of Dr. Lippman’s research at the Royal Institute of Technology in Stockholm and at the University of Uppsala, Scandinavia’s oldest university...” technical advances, so Dr. Lippman became the leader of a large medical staff that encouraged this progressive research.

Raising Funds for Research Dr. Lippman wanted to take Professor Harman’s work one-step further and explore the relationship between free radicals and aging. He turned to Professor Sven Brolin, chair of the University of Uppsala’s Department of Medical Cell Biology and Professor Gunnar Wettermark, chair of the Royal Institute of Technology’s Department of Physical Chemistry, for assistance in raising funds for research.

Dr. Lippman was successful, receiving significant medical and chemical grants from the Swedish Research Council to develop antiaging strategies based on Professor Harman’s groundbreaking discovery of the action of free radicals and the role of radical scavengers (anti-oxidants) in destroying or inhibiting them. The Swedish Research Council financed

years of Dr. Lippman’s research at the Royal Institute of Technology in Stockholm and at the University of Uppsala, Scandinavia’s oldest university, which has an anatomy lecture hall built in the 15th century.

Dr. Lippman’s research, into the role that free radicals play in the breakdown of the aging body, led him to develop one of the most potent antioxidant combinations yet known, a unique cocktail containing NDGA, it is called ACF228®.

No Typical Scientist Dr. Lippman’s normal lab attire—jeans, a khaki shirt, and ostrich leather boots— breaks from the conventional notion of a white-coated scientist. Before his work in antiaging research that made him famous, he ate junk food. Now, a typical lunch for him is salmon sashimi and salad or bi-bim-bop with a bowl of miso soup. He even developed his own recipe for sugar-free, gluten-free, walnut

HO

cinnamon pumpkin muffins. t In speaking, Dr. Lippman presents an easy smile and laugh. He may not look like a typical scientist, but his passion for longevity research is real. His innovative research into free radical pathology helped put antioxidants on the map, in the dictionary and in the supermarket.

Once funding was in place, Dr. Lippman gathered a team of five prominent Swedish scientists to help him develop methods for measuring free radicals and biochemical changes related to aging: Professor Agneta Nilsson, a nutritionist and alternative medical professional with advanced degrees in nursing and teaching; Dr. Ambjörn Ågren, M.D., PhD, who had received numerous awards in the field of emergency medicine; Professor Mathius Uhlén, PhD, a civil engineer, molecular biologist, and later, professor and chair of the Royal Institute of Technology’s Department Molecular Biology; Evald

Cellular Model—A Better Choice The research team’s first task was to find a cellular model rather than an animal model to test for life extension, since Professor Harman’s model of waiting for mice to grow old and die was costly and took years of patience before the

Figure 2: The chemical formula of NDGA

HO OH OH 22

Koitsalu, an engineer and expert in computer hardware and software; and Dr. Kaj Alverstrand, a psychologist and consultant to Volvo.

With these tremendous financial and personnel resources, Dr. Lippman was able to achieve great leaps in the field. Indeed, Paul Glenn of the Paul Glenn Foundation for Antiaging Research said that Dr. Lippman’s work was; “light years ahead of everyone else!”

Dr. Lippman’s research resulted in a patent for NDGA (see figure 2) and a multi-ingredient free radical scavenger product that promotes better health and longevity: ACF228®.

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Figure 3: Strong radical-scavenger fed mice (below) versus the surviving control mouse (top).

results came in.

Dr. Lippman’s team had access to many different types of living cells in culture, such as human cells of the heart, brain, liver and central nervous system. In 1980, Dr. Lippman invented special probes that would penetrate cell interiors without harming them. For the first time in the history of cell biology, scientists were able to measure free radicals in living cells (4). The first probe, carnitinylmaleate luminol (CML), measured superoxide radicals in live human liver cells. Dr. Lippman and his team went on to test many different combinations of nutrients.

Developing the formula combinations was a tedious process. Live cells were harvested from biopsies, then separated and kept metabolically alive in special culture dishes heated to a constant 98°F. The live cells were removed as needed by the research team and tested

for their health by means such as measurements of adenosine triphosphate (ATP), the power source or ‘gasoline’ of most cell activities.

Then the cell cultures were impregnated with special CML probes and incubated with different mixtures of vitamins and nutrients. Dr. Lippman’s team eventually tested 227 different mixtures to find an optimal mixture with pronounced longevitypromoting characteristics.

Mixture number 228 was found to work best and this and several other promising mixtures such as 223 were tested further in mice and human volunteers.

Now named ACF228®, the mixture proved successful in extending mice health and life spans, (see figure 3)

Scientific Community Astounded The team published its results in more than twenty prominent medical journals.

The work astounded the Swedish scientific community and Dr. Lippman was nominated for a Nobel Prize in Medicine in 1996.

Further tests were conducted on hundreds of human volunteers recruited from several Swedish hospitals (3).

The volunteers were tested to establish their normal levels of fatty-acid peroxides, which are free-radical downstream products and then were fed varying amounts of ACF228®.

Once again, the mixture known as ACF228® caused peroxide levels to decline the fastest. Dr. Lippman and his researchers performed other human tests that indicated ACF228® also had beneficial effects on the skin and sexual function (3).

“We found that the ACF228®

formula is truly beneficial,” Dr. Lippman says. “It was especially helpful for middleaged and older people; their liver function became like that of teenagers. Often people experience reduced liver function as they age, especially if they have abused their bodies with heavy consumption of alcohol and a high sugar diet, causing metabolic syndrome (5).

ACF228® offers protection from a multitude of free radicals in the body.”

Ultimately, the ACF228® formula was approved for use by regulatory agencies in both Sweden and Italy and then became patented in the United States.

“Dr. Lippman’s team eventually tested 227 different mixtures to find an optimal mixture with pronounced longevity-promoting characteristics.

Mixture number 228 was found to work best...” www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

23

The unique and complex formula contained in each capsule of ACF228® is shown below: • 100 mg N-acetyl cysteine This helps to destroy the most common radical, the superoxide anion, (a negative Ion) radical through a process known as quenching.

• 3 mg nordihydroguaiaretic acid (NDGA) This helps to stop fatty acids, (the essential building blocks of all cells) from becoming radicalized.

• 5 mg butylated hydroxytoluene (BHT) This destroys the most damaging of all radicals, the hydroxyl radical. The hydroxyl radical has only a nanosecond half-life and thus, ordinary antioxidant vitamins or cellular enzymes cannot quench it.

• 100 mcg selenium This is a second-tier radical scavenger renowned for helping recharge the cells’ antioxidant reserves. It also bonds to the toxic metal mercury and other heavy metals.

• 0.025 mcg catalase This essential enzyme is critical to deactivating and converting hydrogen peroxide to ordinary water.

Insufficient catalase increases the likelihood of hydroxyl radicals.

• 83 mg l-carnosine This is a premier anti-glycator (anti-cross-linker) that helps to counter the hardening of the lens of the eye and improves arterial elasticity.

• 50 mg dimercaptosuccinic acid (DMSA) This is the premier extractor of heavy metals, through a process called ‘chelation.’

• Vitamins B6 (17 mg), B12 (10 mcg) and methylfolate (800 mcg).

These are essential methylation vitamins for any serious antiaging program.

• Also included are iodine (1.5 mg) and potassium iodide (2.5 mg), these help to improve thyroid function.

Indeed, based on these criteria, Dr. Lippman could rest easy. But he isn’t resting. The energetic, youthful-looking father of three sons and four grandchildren still goes to his lab daily. And what is this Nobel Prize nominee working on today for the betterment of humankind tomorrow?

Dr. Lippman continues his medical research, focusing on improved methods of delivering important vitamins and hormones, including transdermal delivery methods.

“The response to ACF228® worldwide has been great and that is indeed gratifying,” says Dr. Lippman. “You know,

we should all be able to live to 120 years and perhaps even beyond. We don’t because of the free radical damage and declining repair hormones our cellular systems sustain.

Our brains shrink, our arteries become hardened and our liver function declines, mostly because of free radical

References 1. Strong, R et. al., Oct. 2008, Aging Cell, 7(5), pp. 641-650.

2. Strong, R et. al, Jan 2013, J Gerontology, 68(1), pp. 6-16.

3. Harman, D., Jul. 1956, J Gerontology, 11(3), pp. 298-300.

4. Lippman, R, 1987, US Patent No. 4,695,590.

5. Lippman, R, 1980, Experimental Gerontology, vol. 20, pp. 46-52.

5. Lippman, R. 2009, Stay 40, Outskirts Press Inc., Boulder, Colorado.

24

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pathology and damaged endocrine glands. Aging is the ultimate disease. If ACF228®, with its unique blend of natural ingredients can help people to prevent their premature onset, then I will have lived my life knowing that it has been a success.”

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Dr. Thierry Hertoghe

327 pages

$299.99

DIAGNOSTICS

CONTAINS

RETAIL

PRICE

BIO-CLIP-CUFF™ CUFF

Arterial stiffness monitor - one complete kit

$160

$149.99

FOODSAFE NEW

Blood spot food allergy test-kit for 95 foods

$250

$239.99

25 Nitric Oxide Saliva Test Strips

$30

$24.99

VIELIGHT LASER

Vielight 633 intranasal LED

$295

$274.99

HORMONES

CONTAINS

RETAIL

PRICE

®

NEO40 ® ®

OTHER INFO

ALDO-PRO™

15x 125 mcg capsules

$90

$79.99

ALDO-SPRAY™ NEW

5ml 10mg nasal spray

$140

$129.99

2.5ml nasal spray

$30

$24.99

60 x 25mg capsules

$20

$17.99

50ml 100mg (90-7-3%) jar cream

$50

$44.99

100 x 5mg capsules

$25

$19.99

60x 3mg tablets

$30

$21.49

DESMOPRESSIN MINURIN® DHEA DHEA-25-PRO™ NEW

ESNATRI™ (BIOIDENTICAL TRIPLE ESTROGENS) ESNATRI™ HYDROCORTISONE HYDROCORT-PRO™ MELATONIN MZS™ (*UK CAN ORDER VIA WWW.MELATONINZNSE.COM)

*

PRICES CORRECT AS OF JULY 2016

ALDOSTERONE

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Price List Page 1

PRICES JULY 2016 PULLOUT HORMONES

CONTAINS

MELA-MAX™ NEW

60x 10mg capsules

OTHER INFO

RETAIL $25

PRICE $17.49

MELA-PRO™ NEW

2 oz. 90mg liquid

$20

$14.99

5ml 500IU nasal spray

$70

$59.99

MSH (MELANOCYTE STIMULATING HORMONE) MSH2-PRO™ OXYTOCIN OXY-LOZENGE™ NEW

100x 5IU lozenges

$70

$59.99

OXY-PRO™

5ml 500IU nasal spray

$55

$49.99

OXY-SUB20™

30x 20IU sublingual trouches

$90

$79.99

50x 100mg capsules

$25

$21.49

50ml 2.5G cream

$35

$29.99

90x 200mg capsules

$110

$99.99

PREGNENOLONE PREG-PRO™ PROGESTERONE (BIOIDENTICAL 5%) PROGEST-PRO™ THYMUS THYM-UVOCAL® THYROIDS (NATURAL) ERFA®

100x 30mg tablets

$60

$59.99

ERFA®

100x 60mg tablets

$80

$79.99 $119.99

ERFA®

100x 125mg tablets

$120

NATURE®

100x 15mg tablets

$50

$39.99

NATURE®

100x 32.5mg tablets

$60

$49.99

NATURE®

100x 65mg tablets

$70

$59.99

NATURE®

100x 97.5mg tablets

$80

$69.99

NATURE®

100x 130mg tablets

$90

$79.99

THYROIDS (SYNTHETIC) T3 (T3-PRO™)

50x 20mcg tablets

$35

$29.99

T4 (EUTIROX®)

50x 150mcg tablets

$25

$19.99

20x 5mg sublingual tablets

$235

$199.99

VASO-PRO™

5ml 500IU nasal spray

$80

$69.99

MEDICINES

CONTAINS

RETAIL

PRICE

30 x 100mg chewable tablets

$25

$19.99

ARIMIDEX®

28x 1mg tablets

$70

$59.99

ANASTRO-PRO™

28x 100mcg capsules

$34

$29.99

30x 2.5mg tablets

$25

$19.99

8x 0.5mg tablets

$50

$39.99

14x 500mg tablets

$25

$19.99

40x 1mg tablets

$20

$17.49

14x 100mg tablets

$20

$14.99

30x 0.5mg capsules

$50

$39.99

TRH (THYROTROPIN RELEASING HORMONE) ABARIS™ VASOPRESSIN

OTHER INFO

ACARBOSE GLUCOBAY® ANASTROZOLE

BROMOCRIPTINE PARLODEL® CABERGOLINE DOSTINEX® CIPROFLOXACIN CIPRO® COLCHICINE COLCRYS® DOXYCYCLINE MONODOKS® DUTASTERIDE AVODART® FINASTERIDE

Price List Page 2

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PRICES JULY 2016 PULLOUT MEDICINES

CONTAINS

RETAIL

PRICE

PROSCAR®

28x 5mg tablets

OTHER INFO

$30

$24.99

7x 50mg capsules

$34

$29.99

100x 300mg capsules

$40

$34.99

20x 500mg tablets

$39

$34.99

FLUCONAZOLE (DIFLUCAN®) GENERIC GABAPENTIN NEURONTIN® GABOB GAMIBETAL® METFORMIN METFORAL®

50x 500mg tablets

$24

$19.99

GLUCOPHAGE® NEW

100x 850mg tablets

$30

$24.99

MET-PRO™ NEW

100x 500mg tablets

$25

$19.99

56x 50mg tablets

$60

$49.99

30x 4.5mg capsules

$60

$49.99

30x 250mg powder sachets

$24

$19.99

30x 50mg tablets

$19

$14.99

30x 1mg capsules

$90

$79.99

60x 4mg tablets

$50

$39.99

10x 50mg tablets

$25

$19.99

60x 12.5mg tablets

$65

$59.99

16x 250mg tablets

$20

$14.99

28x 5mg tablets

$60

$49.99

EFEXOR®

14x 37.5mg tablets

$20

$14.99

NUTRITION

CONTAINS

RETAIL

PRICE

OSCN kit

$90

$79.99

90x 100mg capsules

$25

$21.49

ACF228®

50x capsules

$60

$49.99

INHALER (BREATHE-EASY™)

1 complete kit

$160

$149.99

90x 75mg tablets

$25

$19.99

MILNACIPRAN (SAVELLA®) IXEL® NALTREXONE (LDN) NALTREX-PRO™ PENICILLIN PENILEVEL® PHENYTOIN (DILANTIN®) EPANUTIN® PROPRANOLOL INDERAL® RASAGILINE AZILECT® REBOXETINE (DAVEDAX®) EDRONAX® ROXITHROMYCINE RULID® STABLON® (TIANEPTINE) STABLON® (TIANEPTINE) TETRACYCLINE TETRA® VALDOXAN® (AGLOMELATINE) VALDOXAN® (AGLOMELATINE) VENLAFAXINE

OTHER INFO

1ST LINE™ 1ST LINE™ 5HTP (5-HYDROXY-TRYPTOPHAN) 5HTP-PRO2™ ACF228®

AMINOGUANIDINE AMINO-PRO™ ANDRO-PRO™

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PRICES JULY 2016 PULLOUT NUTRITION

CONTAINS

RETAIL

PRICE

ANDRO-PRO™

60x capsules

OTHER INFO

$45

$39.99

60x 20mg capsules

$25

$21.49

BG-CREAM™ NEW

50ml tube cream

$45

$39.99

BG-PRO™ NEW

60x 400mg capsules

$35

$29.99

120x 10mg capsules

$25

$21.49

60 capsules

$110

$94.99

60 capsules

$35

$29.99

90 capsules

$40

$34.99

30x 100mg capsules

$30

$24.99

30x 125mg capsules

$25

$19.99

100x capsules

$45

$39.99

60x 100mg capsules

$45

$39.99

120x 10mg capsules

$30

$24.99

ATP (ADENOSINE TRIPHOSPHATE) ATP-BOOST™ BETA-GLUCANS

BHT (BUTYLHYDROXYTOLUENE) BHT-PRO™ BOLUOKE® (LUMBROKINASE) BOLUOKE® (LUMBROKINASE) BONE-PRO2™ BONE-PRO2™ CAN-C™ PLUS CAN-C™ PLUS COQ10 (COENZYME Q10) COQ10-SR™ CURCUMIN CURCUMIN-SR™ DI-INDOLYMETHANE DIM-PRO2™ DMSA DMSA-PRO™ NEW EDTA EDTA-PRO™ NEW GEROVITAL-H3® 5x 5ml ampoules

$60

$49.99

GEROVITAL-H3® ORIGINAL

25x 100mg tablets

$35

$29.99

GH3-PRO™

60x 100mg tablets

$20

$14.99

2 oz. spray

$40

$39.99

2 oz. 225mg liquid bottle

$20

$14.99

60x 250mg capsules

$25

$21.49

100x 5mg capsules

$25

$21.49

50x 500mg capsules

$25

$19.99

2 oz. 400mg bottle liquid

$15

$12.49

16 oz. liquid bottle

$25

$19.99

GEROVITAL-H3®

GLUTATHIONE ACG® IODINE IODIDE-PRO™ L-CARNOSINE CARNO-PRO™ LITHIUM OROTATE LITH-PRO™ L-TRYPTOPHAN L-TRYP-PRO™ MAGNESIUM MAGNESIUM-PRO™ MINERAL MOUTHWASH MIN-MOUTH™ NEW MITO-PRO2™

Price List Page 4

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PRICES JULY 2016 PULLOUT NUTRITION

CONTAINS

RETAIL

PRICE

MITO-PRO2™ NEW

75G powder

OTHER INFO

$50

$44.99

60x 5mg capsules

$70

$69.99

30x lozenges

$60

$59.99

30x 5ml sachets liquid

$30

$29.99

30 x 100mg capsules

$60

$54.99

PEO-PRO™ NEW

120x 725mg capsules

$40

$34.99

PEO-LIQUID™ NEW

236ml bottle liquid

$65

$59.99

2 oz. 99mg bottle liquid

$20

$14.99

30x 20mg capsules

$45

$39.99

60x capsules

$30

$24.99

30x 150mg capsules

$35

$29.99

20x 400mg enteric coated tablets

$35

$29.99

2 oz. 300mg bottle liquid

$20

$14.99

2 oz. spray bottle

$30

$29.99

3.5ml mouth spray

$65

$64.99

4x 500ml liquid bottles

$135

$134.99

TA65®

90x capsules (250 dose)

$600

$599.99

TA65®

30ml bottle cream

$500

$499.99

100x 5,000 IU capsules

$19

$14.99

8 oz. liquid bottle

$25

$19.99

2 oz. spray bottle

$40

$39.99

MITOQ® MITOQ® NEW NADH NADH NEW COMING SOON NEO40® NEO40® NICOTINAMIDE RIBOSIDE NAD+PRO™ NEW COMING SOON NOVISYN® (HYALURONIC ACID) NOVISYN® (HYALURONIC ACID) OXALOACETATE OXALO-PRO™ NEW PEO (PARENT ESSENTIAL OILS)

POTASSIUM POTASSIUM-PRO™ PQQ (PYROLOQUINOLINE QUINONE) PQQ-PRO™ NEW PROSTATE-PRO2™ PROSTATE-PRO2™ RESVERATROL RESVERATROL-SR™ SAME (S-ADENOSYL-L-METHIONE) SAME-PRO™ SELENIUM SELENIUM-PRO™ SILVER PROTEIN ACS® STEM CELL WORX® STEM CELL WORX® NEW SYMPROVE® SYMPROVE® NEW TA65®

VITAMIN D3 D3-5000™ VOLT-PRO™ (ELECTROLYTES) VOLT-PRO™ (ELECTROLYTES) ZEOLITE ACZ®

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Price List Page 5

PRICES JULY 2016 PULLOUT PEPTIDES

CONTAINS

OTHER INFO

RETAIL

PRICE

$15

$12.49

RETAIL

PRICE

120ml 120mg bottle liquid

$175

$159.99

5ml 500 IU nasal spray

$80

$69.99

ADRENALS (GLANDOKORT®)

20x capsules

$75

$69.99

BLADDER (CHITOMUR®) NEW

20x capsules

$75

$69.99

BLOOD VESSELS (VENTFORT®)

20x capsules

$75

$69.99

BONE MARROW (BONOMARLOT®) NEW

20x capsules

$75

$69.99

BRAIN/ CNS (CERLUTEN®)

ZINC ZINC-PRO™

2 oz. 50mg liquid bottle

PEPTIDES

CONTAINS

OTHER INFO

GHRP-2 GHRP2-PRO™ GHRP-6 RELEASE-PRO™ PEPTIDE BIOREGULATORS

20x capsules

$75

$69.99

CARTILAGE (SIGUMIR®)

20x capsules

$75

$69.99

HEART (CHELOHART®)

20x capsules

$75

$69.99

KIDNEYS (PIELOTAX®)

20x capsules

$75

$69.99

LIVER (SVETINORM®)

20x capsules

$75

$69.99

LUNGS (TAXOREST®) NEW

20x capsules

$75

$69.99

MUSCLE (GOTRATIX®)

20x capsules

$75

$69.99

OVARIES (ZHENOLUTEN®)

20x capsules

$75

$69.99

PANCREAS (SUPREFORT®)

20x capsules

$75

$69.99

PARATHYROID (BOBOTHYRK®) NEW

20x capsules

$75

$69.99

PINEAL (ENDOLUTEN®)

20x capsules

$95

$89.99

PROSTATE (LIBIDON®)

20x capsules

$75

$69.99

RETINA (VISOLUTEN®)

20x capsules

$75

$69.99

STOMACH MUCUS (STAMAKORT®)

20x capsules

$75

$69.99

TESTES (TESTOLUTEN®)

20x capsules

$75

$69.99

THYMUS (VLADONIX®)

20x capsules

$75

$69.99

THYROID (THYREOGEN®)

20x capsules

$75

$69.99

30ml/ 30mg liquid

$200

$189.99

RETAIL

PRICE

40x 300mg capsules

$50

$39.99

30x 420mg capsules

$25

$21.49

20x 750mg capsules

$25

$21.49

60x 250mg capsules

$30

$24.99

20ml 300mg bottle liquid

$90

$84.99

SERMORELIN SERM-PRO™

SMART DRUGS

CONTAINS

OTHER INFO

ADRAFINIL ADRA-PRO™ ANACERVIX® ANACERVIX® ANIRACETAM ANI-PRO™ CENTROPHENOXINE CENTRO-PRO™ DEPRENYL (SELIGILINE) DEP-PRO™

Price List Page 6

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PRICES JULY 2016 PULLOUT RETAIL

PRICE

DEP-TABS™ NEW

SMART DRUGS

50x 5mg tablets

CONTAINS

OTHER INFO

$40

$34.99

JUMEX®

50x 5mg tablets

$59

$49.99

30x 1mg tablets

$40

$34.99

60x 2.25mg capsules

$45

$39.99

60x 30mg tablets

$30

$24.99

50x 10mg capsules

$60

$49.99

50x 10mg tablets

$44

$39.99

60x 50mg tablets

$20

$17.49

20G 200ml bottle liquid

$25

$19.99

40x 300mg tablets

$50

$44.99

120x 10mg capsules

$30

$24.99

50x 150mg capsules

$25

$19.99

RETAIL

PRICE

20ml tube cream

$150

$144.99

2x 5ml vials

$45

$39.99

200ml bottle shampoo

$25

$19.99

60ml spray bottle

$50

$44.99

50ml tube RNA toothpaste

$10

$9.99

GALANTAMINE REMINYL® HYDERGINE® (ERGOLOID MESYLATE) HY-PRO2™ NEW IDEBENONE IDEB-PRO™ MEMANTINE (NAMENDA®) EBIXA® NICERGOLINE SERMION® PICAMILONE PIKAMILON-PRO™

PIRACETAM NOOTROPIL® PRAMIRACETAM PRAM-PRO™ VINPOCETINE VIN-PRO™ XANTHINOL NICOTINATE XAN-PRO™

TOPICALS

CONTAINS

OTHER INFO

BEC5 CURADERM® BEC5 CURADERM® CAN-C™ EYE-DROPS CAN-C™ EYE-DROPS DERCOS® (AMINEXIL) DERCOS® (AMINEXIL) MINMAX-PRO™ (HAIR LOSS LOTION) MINMAX-PRO™ NEW NEYDENT® NEYDENT® YOUTH GEMS® BODY MILK NEW

200ml bottle

$50

$44.99

DAY CREAM NEW

50ml pump

$70

$64.99

FACE PACK NEW

100ml bottle

$55

$49.99

NIGHT CREAM NEW

50ml pump

$70

$64.99

SERUM NEW

30ml dropper bottle

$90

$79.99

TONIC NEW

200ml liquid bottle

$45

$39.99

RETAIL

PRICE

OTHERS

CONTAINS

OTHER INFO

INJECTION PACKS INTRAMUSCULAR

30x syringes, wipes and sharps

$30

$24.99

SUBCUTANEOUS

30x syringes, wipes and sharps

$30

$24.99

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Price List Page 7

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Price List Page 8

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SPOTLIGHT: GHRPS A R E AL ‘OR AL’ ALTER NATIVE TO G H INJEC TION S Ever since Dr. Rudman’s work in the 1980s and then the release of Dr. Klatz’s book ‘grow young with HGH’ in the 1990s, there has been a strong interest in the use of growth hormone (GH) in antiaging medicine.

Dr. Rudman’s research concluded that after injecting his elderly patients with GH, many of them had reversals of their biological age markers by as much as 20-years; specifically having noted improved skin, hair, muscle mass, decreased fat levels and enhanced levels of stamina, strength and well-being.

It’s not entirely surprising given the multifaceted role of growth hormone, plus as its name suggests it is involved in the growth and repair of tissues, but unfortunately blood levels of it decline dramatically past the age of 35 (see figure 1), despite the fact that there is evidence that the pituitary gland continues making significant amounts of it.

GH injections The issue with injecting GH, (brand names include Genotropin®, Saizen® and Zomacton®), other than its expense, is that it does have to be injected to be effective, this is because as a 191 chain amino-acid it simply can’t be absorbed via any other route, thus daily injections can become a chore.

Furthermore, many countries have decided that GH injections be classified as a controlled substance, partly because of its anabolic actions. Controlled substances often require special import and export licenses; this is over-and-above the requirement for a prescription.

Furthermore, the research of Dr. Richard Walker has highlighted that bolus injections of GH are not bioidentical and that as they induce spikes of GH into the blood they could end up damaging the pituitary gland, leading to a down-regulation of its own production of GH, or even to stop GH production altogether.

GHRPs But meanwhile, Dr. Walker’s research has shown that the use of GHRPs, (growth hormone releasing peptides) have a much safer profile whilst enjoying the same benefits- even if they provide them a little more slowly. We would recommend that you read his extensive article in the Aging Matters™ magazine, No3, 2014 to understand fully how they operate. What we can say is

that GHRPs, (GHRP2, GHRP6 and sermorelin) have the following benefits: • They can be sublingually, intra-nasally and even orally, passing into blood and thus avoiding the need for needles.

• Their feedback loop means that they cannot cause the pituitary to down-regulate.

• GHRPs are not controlled substances.

• Rather than inducing a spike of GH in the blood, GHRPs augment (improve) each release of GH naturally into the blood, for which there are several peaks daily, (although the rising from bed peak is the highest one) - see figure 2.

Synergy Sermorelin is actually the precursor to GH, being the first 29 amino acids and is applied via the sublingual route. Sermorelin’s function may be to release existing stores of GH from the pituitary- rather than encourage more production as a pure agonist would.

Dr. Walker has highlighted that combining sermorelin with GHRP2 or GHRP6 has a highly synergistic effect, in some cases eliciting up to a 5x greater quantity of GH into blood, an action that can be equivocated to using injectable GH itself.

Note: You can also hear Dr. Walker discuss this with us on the IAS video page:

www.youtube.com/watch?v=S5OlEhbM7lQ

Differences • GHRP6 may induce more hunger feelings than GHRP2 and could improve levels of IGF1 more. Therefore this option may be better recommend for those who want to put on muscle mass.

• GHRP2 may create less hunger feelings and therefore could be preferable to those who want to stimulate GH for fat loss. Also as the GHRP6 (Releasing-Pro™) is a nasal spray, those who don’t like that feeling may prefer GHRP2-Pro™ since it is an oral liquid simply swallowed.

Figure 1 (top): The typical GH levels in blood with age, note that ‘geriatric’ levels are reached as early as during the 30’s.

Figure 2 (middle) shows the 24 hour profile of subcutaneous (and also intravenous) GH. Compare that to figure 3 (bottom), the natural peaks of GH in both young and elderly patients. Only GHRPs naturally amplify these bioidentical patterns.

Summary GHRPs have created a genuine efficacious alternative; they are simpler/ easier to use and at the same time they have a better/ safer profile than injectable GH.

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27

®

50mcg 8.7mg

Melatonin

90 58

3mg Amount Per Serving

* % Daily Value

Servings per container: 60 Serving Size: 1 tablet

Supplement facts:

Description: MZS is Dr. Walter Pierpaoli’s original melatonin formula containing the additional and supportive agents zinc and selenium. MZS is produced to pharmaceutical standards in Italy and unlike other melatonin preparations MZS has been designed to produce a night peak of melatonin between 1AM and 3AM to mimic the natural behavior of the pineal gland.

Dr. Pierpaoli’s extensive animal and human research has shown that this is important because this action helps to stabilize circadian rhythms, improve hormonal cyclicity and boost immunity.

MZS

www.profound-products.com

Dr. Pierpaoli’s original formula+

™

Formulated and distributed by Profound Products, PO Box 19, Sark GY9 0SB, Great Britain

MZS Dr. Pierpaoli’s original formula ™

Dr. Pierpaoli

MZS Dr. Pierpaoli’s original formula

®

®

Dr. Pierpaoli MZS Dr. Pierpaoli’s original formula

™

Directions: Take 1 tablet before bedtime, ideally between 10PM and 11PM.

% Daily Value * not established Other ingredients: Avicel, mannitol, povidonum and magnesium sterate Selenium Zinc

Dr. Pierpaoli MZS Dr. Pierpaoli’s original formula

Disclaimer: This product and its statements have not been evaluated by the FDA. This product is not intended to treat, cure or prevent any disease.

B EC AU S E NOT ALL MEL ATONIN S AR E CR E ATED EQUAL

Note: Keep in cool dark conditions, out of the reach of children and consume before end of expiry date. Not for use by pregnant or lactating women.

SPOTLIGHT: MZS

™

™

Our melatonin has been formulated by the world’s foremost melatonin expert Dr. Walter Pierpaoli, his Melatonin Zn Se, or MZS™, is totally unique since it is designed to mimic the natural night peak of melatonin- to leave you feeling refreshed and alert the following day.

What does Melatonin do?

Melatonin is vital to protect our hormonal system, regulate immunity and repair our body’s cells. It is commonly used by shift workers and also to treat jet lag and age related sleep disorders, but its abilities go far beyond simply its sleep inducing properties.

The antioxidant effects of melatonin Melatonin is an extremely effective antioxidant; in fact on a molecule to molecule basis; melatonin has proved to be significantly more efficient in neutralizing toxic hydroxyl-

radicals than the two wellknown free radical scavengers, glutathione and mannitol.

ARMD. Remarkably this was true for both the wet and dry forms!

Melatonin’s effects on longevity

Why is Dr. Pierpaoli’s MZS™ more effective than other melatonin supplements?

Melatonin’s effect on longevity is well documented; in fact laboratory tests on rats and mice have demonstrated that melatonin increased their lifespans by 20%. Experts believe melatonin is a vital antiaging product because of its positive effect on aging.

MZS™ and age-related macular degeneration Age related macular degeneration (ARMD) comes in two forms, wet and dry and is a notoriously difficult disorder to treat and is linked to blindness. A 24-month study, (published in NY Academy of Science, 2005, 1057:384-392) on 100 patients showed that after 3 months, the majority of patients taking 3 mg of Melatonin Zn Se nightly had halted the progression of their age related macular degeneration and at 6 months many showed reversal of their

There are three principal reasons, firstly it is of pharmaceutical quality at a dose of 3 mg, secondly it contains the synergistic ingredients of selenium and zinc, but thirdly and most importantly- it is designed to release at a very specific time. Dr. Pierpaoli’s research led him to perfect a formula that exactly mimics the pineal gland’s release of melatonin.

Thus means that MZS™ is the only melatonin supplement to follow nature’s own night peak.

+

60 tablets Dietary Supplement

™

Melatonin is produced by the pineal gland at night to regulate our circadian rhythm, (sometimes called the sleep wake cycle). As we age the amount of melatonin we produce reduces resulting in many older people sleeping less and having a lower quality of sleep.

Dr. Pierpaoli

®

MZS Dr. Pierpaoli’s original formula ™

Dr. Pierpaoli

®

MZS™ is so much more than a sleep aid Melatonin has had so many published benefits it is impossible to list them all here.

From jet lag and shift work to well-being and antiaging, no other melatonin supplement offers the endorsement of Dr. Pierpaoli, or the exact formula used in all of his renowned clinical trials. If you’ve tried other melatonin and didn’t notice any significant effect, then we highly recommend you try Dr Pierpaoli’s MZS™ for a superior experience.

Dr. Pierpaoli’s free ebook ‘The key of Life’ can be read here:

http://bit.ly/1vdB31y

How much should I take?

Take half to one 3 mg tablet at bedtime only; do not take more than two tablets. By taking MZS™ between 9pm and 11pm you will create a night peak between 1am and 3am, this is the most natural and normal time to have the highest melatonin levels.

Left: Melatonin levels in blood over 24-hours This graph compares Dr Pierpaoli’s melatonin formula (red line) to the natural release of melatonin (dark blue). Two other common types of melatonin supplements (light blue and green lines) demonstrate that sublingual melatonin peaks too soon and that time released formulas peak too late.

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Above: Here are some before and after Fundus photos showing the benefit of Melatonin Zn Se. (Top before, below: after treatment).

SPOTLIGHT: BIOCLIP ® CUFF MONITOR ING YOU R VA SCU L AR CONDITION The BioClip® Cuff is a simple way of assessing both your blood pressure condition and your arterial flexibility; plus, you can use the BioClip® Cuff in the comfort of your own home because you simply attach the device to your arm just like an ordinary blood pressure cuff.

What does the BioClip® Cuff measure?

The BioClip® Cuff provides a series of metabolic indicators that you can use to improve your lifestyle and so help to prevent the causes of cardiovascular disease. We all know the risks of being overweight, of having high cholesterol or suffering from high blood pressure. We also know how to reduce those risks – by exercising more, not smoking, reducing our alcohol intake and eating a balanced diet.

These include: • Diastolic blood pressure • Systolic blood pressure • The heart rate • Vascular condition – which linked to arterial flexibility.

Few of us know about the hidden dangers of arterial inflexibility, or how to measure it. This is where the BioClip® Cuff is unique being as it is the first at-home device able of delivering this information to you within minutes.

What is arterial flexibility?

The BioClip® Cuff works by evaluating your arterial flexibility, which experts say is one of the most important

Above: The BioClip® Cuff readout, showing both blood pressure, heart rate and vascular flexibility results.

risk factors when it comes to assessing the likelihood of a heart attack or stroke. Arteries are important because they’re responsible for blood flow around your body via your cardiovascular system. To work properly, it’s crucial that your arteries are kept healthy.

The poorer your vascular condition, the greater your chances of serious health issues Our arteries usually stiffen with advancing age. This brings with it a greater risk of a potentially fatal heart attack, heart failure or stroke, as is shown in figure 1.

You may not recognise the heart failure symptoms as your arteries begin to stiffen Unfortunately arterial stiffness can occur without warning.

Often there are no symptoms of cardiovascular disease and

people don’t suspect they are in danger until they suffer an attack. Figure 2 highlights that arterial stiffness is strongly correlated with mortality The BioClip® Cuff provides a cardiovascular condition scale, shown by LED bars - that are either within the green zone (good), yellow zone (fair) or red zone (poor).

It is important to note that like blood pressure, vascular condition should be monitored over time and not just taken as one reading. The BioClip® Cuff makes this simple by averaging your tests over time and therefore provides a more accurate result.

BioClip® Cuff provides reassurance and a vital early warning system that helps you to be aware of changes and therefore keep your vascular condition in check.

Left: Arterial stiffness is a biomarker of aging, as shown here arterial stiffness tends to increase with age.

Source: Millasseau et al., Clinical Science, 2002.

The BioClip® Cuff is easy to use The BioClip® Cuff doesn’t puncture your skin and is used on its own, without any additional attachments. The procedure is straightforward and you don’t need to link to a computer, as the results are shown on the BioClip® Cuff screen. Note: If you want to see it in action there is a video available at the IAS website.

Armed with this information it’s easy to keep a check on your cardiovascular health and the risks associated with arterial stiffness, such as heart attacks and strokes. Armed with this information it is possible to make changes to your lifestyle and supplement program to improve results and keep you biologically younger!

Above all, the BioClip® Cuff provides reassurance and a vital early warning system that helps you to be aware of changes and therefore keep your vascular condition in check.

Left: Three groups (each approximately 80 persons) were monitored over 140 months for their survivability. Those in the flexible artery groups (marked as PWV <9.4 m/s and 9.4-12.0 m/s) survive best losing approx. 25%. But those in the hard artery group (marked as PWV >12.0 m/s) 90% of them die in the same period. Source: ESRD, Blacher et al. Journal of Circulation, 1999 www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

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SPOTLIGHT: BIOIDENTICAL HORMONES NATU R AL ESTROG EN S AND PROG ESTERONE FOR WOMEN IAS carries a wide range of bioidentical hormones - a term that means ‘natural to and in the body’. In this featured section we are focusing on the use of natural estrogens and progesterone for women, which of course are normally utilised to aid the menopause.

When hormone replacement therapy (HRT) was developed in the 1920s, estrogens had to be derived from horse urine because a laboratory solution was too difficult/ expensive to synthesize. But today everything has changed, yet this ancient practice continues- these facts have been pointed out by Dr. Wright in his best-selling book ‘Stay Young & Sexy’ Horse estrogens are, as you might expect, not identical to human; after all humans don’t have manes nor do they have hooves! Yet the industry is stuck in this old loop, despite the fact that natural (bioidentical) estrogens can be easily produced now. Some people believe that the known side-effects from ‘traditional HRT’ are due to the fact that the hormones given are not correct.

Above: Stay Young & Sexy

By Dr. Wright

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Esnatri™, a unique tri-estrogen Esnatri™ is our bioidentical triple estrogen cream, which many women use, confident they have chosen the best bioidentical estrogen cream available.

It comes directly from the work of Dr. Wright who has shown that the majority of women produce estrogens in the ratios of 90% estriol, 7% estrone and 3% estrone.

Above: As Dr. Wright himself has said many times; “we only have to copy nature, the right molecules at the right times and doses.”

Most tri-estrogen preparations attempt to replicate the human hormones estriol, estradiol and estrone, apply them in the ratio of 80:10:10, while some even entirely over-look estriol, claiming

it is a weak estrogen. But, women naturally produce high levels of estriol and it is considered to have anticarcinogenic effects.

Esnatri™ use The Esnatri™ cream can be applied by daily rotation to your neck, upper chest, breasts and behind the knees, or inner thighs. A typical starting dose is 2 mg, start from day one (of what would have been the start of your menstrual cycle) and continue until day 25.

Then you should stop for five days, before repeating the application at the start of the next menstrual cycle. During these last few days, the estrogen receptors are being allowed to ‘rest’ as they have been accustomed.

Progesterone Progesterone is the counterbalance to estrogens. Indeed, whilst women can significantly decline in estrogen levels during menopausethey rarely reach zero production levels, whereas progesterone

can sometimes not be measured at all in elderly women.

It is also the low of progesterone that most significantly impacts bone strength, leading onto osteoporosis, so there are numerous reasons to ensure that progesterone is also taken alongside an estrogen therapy.

IAS provides a 5% strength natural progesterone cream.

Typical doses are 25 mg to 30 mg of progesterone applied on day 10 and continuing to 25. The start date varies according to the usual timing of your ovulation. Note: As with the Esnatri™ cream, stop for the last five days of your cycle so that the estrogen receptors have their accustomed ‘rest’ period.

Remember, your hormone replacement therapy should be overseen by a physician and should not be undertaken if you have undergone cancer treatment.

“Esnatri™ is our bioidentical triple estrogen cream, which many women use, confident they have chosen the best...”

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SPOTLIGHT: BIOIDENTICAL HORMONES OX Y TOCIN FOR PA SS ION AND S E X IAS carries a wide range of bioidentical hormones - a term that means ‘natural to and in the body’. In this featured section we are focusing on oxytocin.

What is oxytocin?

Oxytocin is a hormone produced by the hypothalamus, but excreted via the pituitary gland. Its orthodox medicine role is to help women give birth, since the large dose that’s injected helps relaxes the uterus and alleviates the passage of the child into the world for the mother.

Above: Dr. Thierry Hertoghe

However, as we will discover and has been highlighted by Dr. Thierry Hertoghe’s book; ‘passion, sex and longevity, the oxytocin adventure’ -it has many other roles to play too.

The love hormone Oxytocin has been dubbed ‘the love hormone’, why would this be? Principally because oxytocin can induce feelings of bonding and care and not just

between individuals, but even with animals too!

Oxytocin measurements have been taken between lovers, friends, relatives, parents and their children etc. From those results, it has been noted that oxytocin levels are higher when they are in their presence. Mothers naturally bond with their children, but even men, (especially those who experience the live birth), express their emotions as wanting to care and protect their offspring, these effects may be attributable to the release of oxytocin hence triggering the bond. On the other side of the coin, psychopaths are notoriously low in their oxytocin levels, which may be a cause of their uncaring feelings towards other humans.

The pain and orgasm connection Fibromyalgia can be a very debilitating disorder with a lot of pain, sometimes constant for those who suffer with it. In women it was noted that when they were experiencing an orgasm they felt no pain

at all. Later, it transpired that women undergo a burst of oxytocin during orgasm. Trials were undertaken to see if oxytocin supplementation could alleviate the pain of fibromyalgia, there was some success, but the side-effect noted was that those women now enjoyed multiple orgasms! This was a fact picked up on by the popular press and is probably singularly the action most responsible for bringing oxytocin into the public gaze.

Synergy Dr. Hertoghe has explained that some folks will not feel the effects of oxytocin. This is principally because of two reasons, (if we consider that the dose is correct for that individual). Firstly, that some people are ‘low’ in their own principal sexhormone, so if a man is low testosterone, or if a woman is low estrogen, it is possible that oxytocin will not elicit its full potential in those persons.

The other issue could be low vasopressin; vasopressin is a counterpart

to oxytocin, produced and released via the same glands. In cases of vasopressin deficiency, the patient may enhance the oxytocin experience by adding one or two sprays (10 IU each) of vasopressin via the Vaso-Pro™ nasal spray.

Dosing As might be expected doses are very dependent upon its use. However for social or sexual enhancement, one can consider 5 IU to 10 IU a ‘typical’ dose. In fact, Dr. Hertoghe has somewhat reduced the doses that he recommends in his book, (transmitted via personal conversation to me).

Currently IAS is providing Oxy-Sub™ in 20 IU trouches (a soft sublingual tablet), these can therefore be cut into half or quarter for a dose of 5 or 10 IU and should be placed under the tongue and allowed to melt.

The other option is Oxy-Pro™ which is applied intranasally delivering 10 IU per spray.

“...oxytocin can induce feelings of bonding and care and not just between individuals, but even with animals too!”

Dr. Thierry Hertoghe’s book, “Passion, sex and longevity - the oxytocin adventure”, details its roles and uses in a ‘how to’ guide form.

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SPOTLIGHT: CAN-C

™

A B R E AK THROUG H FOR C ATAR AC T Can-C™ eye-drops are the original™ brand- developed by Innovative Vision Products (IVP). This group were the first to research, publish and prove how eye-drops can reduce and even eradicate cataract. Accordingly there are active US and EU patents (and others pending) on this unique and special product.

Unique formula:

Clinical trial:

Can-C™ eye-drops are the formula from the original published human trials.

They contain a purified and racemized form of n-acetylcarnosine (made in Japan); this natural di-peptide has potent anti-glycating and antioxidant properties that prevents lipid peroxidation.

Note that the formula is important- it’s not all about the n-acetylcarnosine; the specific carrier agents and their purity are also important. If you look at the Can-C™ formula you will see differences to the copycats, (remember it is only Can-C™ that is patented in recognition of the original work). If you want the best possible results in the fastest possible time, then choose Can-C™ to deliver them according to the clinical trials.

Patients placed two-drops of Can-C™ into their eyes twice daily for a 6-month period, the outcome was:

• 90% saw an improvement in their visual acuity.

• 88.9% of patients showed improvement in the clarity of their lens.

There have been numerous reports of cataract shrinkage and even disappearance with documented evidence that Can-C™ eye-drops remain effective (and safe) more than 24-months later. The most commonly expressed initial reports are that glare is significantly improved, (for example night driving is much safer) and color perception is enhanced.

Improving eye-sight: More evidence is mounting that Can-C™ is efficacious for many conditions

including: • Cataracts (particularly the senile version) • Glaucoma • Presbyopia • Corneal disorders • Eye strain • Ocular inflammation • Blurred vision • Vitreous opacities and lesions • Diabetes mellitus complications • Contact lens users • Dry eye syndrome Of special interest may be to persons who wear contact lenses. This is because Can-C™ inhibits the accumulation of lactic acid and therefore contacts can be worn for longer periods without pain.

We have also received reports that Can-C™ not only aids dry-eye syndrome with its lubricants, but that Can-C™ helps to unclog proteins from the lacrimal ducts, thus releasing more

Before: Right: A woman’s eye shows the cataract before treatment.

Far Right: 5-months later after use of Can-C eye-drops (two drops twice daily), there is no longer a visible cataract and eyesight has improved.

Dr. Kyriazis book, ‘The Cataract Cure’, details the usefulness and evidence of Can-C™ eye-drops.

It is now available as a FREE e-book at:

www.antiaging-systems.com/can-c-ebook

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natural tears onto the eye.

In a similar way, it is also believed that the unclogging of proteins in the eye’s drain, (the Schlemm valve), helps to reduce intraocular pressure and thus aids glaucoma.

Can-C™ Plus capsules In addition to the eye-drops, Can-C™ Plus capsules are also available. They are strongly recommended to be used in combination with the eye-drops- if you have ripe (long existing) cataracts.

Above: Can-C Plus capsules

After:

SPOTLIGHT: PEOS

®

S U PPLYING AND BAL ANCING OMEGA S NATU R ALLY Most people are familiar with the benefits of omega oils for their health and in particular to reduce inflammation. Indeed cod-liver oil supplements are the world’s most popular supplement, but recently Professor Brian Peskin’s research which is all contained in his new book – the PEO solution - is causing quite a stir and may make many folks to rethink and change their stance.

Professor Brian Peskin and the cover of his latest book - the PEO solution

We are referring to his discovery that the body naturally uses plant oils to make its own omega 3 and 6, thereby satisfying a precise balance according to need- providing the ‘raw materials’ are available. Professor Peskin has termed the phrase PEO as the acronym for ‘parent essential oils.’

Professor Peskin states openly that he has found this information hidden in the scientific literature and never once found it referred to in the medical literature. Why does it matter? Because as he says, it means that physicians are unaware of these facts and therefore they continue to advocate super-physiological doses of omegas from fish oil, which may be actually doing more harm than good!

It’s a lot to swallow, (no pun

intended) and we can’t do his research justice on a single page, which is why we recommend his book, or take a look at the Aging Matters™ magazine No1, 2015 in which Professor Peskin’s article is the lead story. Let’s summarise the advantages of the PEOs: • The plant oils live in our environment, (typically around 50-60°F); hence they do not go rancid at room temperature.

Cold water fish live in a cold environment (typically around 30-40°F), therefore PEOs represent a much more stable product.

• The PEOs are obviously a nonanimal source and therefore can be considered more suitable for those wanting to avoid animal based products.

• The PEOs represent a sustainable source, since there is already too much ‘pressure’ on the seas to provide both fish and even krill stocks.

• The PEOs enable the body to produce its own internal essential fatty acids (EFAs) and correct its own balance. This has not been shown to be the case with fish oil supplements.

Why not fish oil?

Figure: How is fish oil made? It often does not start as the healthiest possible source!

Professor Peskin maintains that the super-high doses in fish oils are extreme when compared to those manufactured within the body.

Furthermore, even the omega 3 to

omega 6 balance OXYGEN MAGNETS! they provide could be EFAs work like tiny “magnets” drawing Oxygen EFAs oxygen into all cells, tissues wrong and that the and vital organs.

O O body may actually Reduce oxygen by only 1/3 and a cell O turns cancerous, forever! require more omega HEART LUNGS 6 than is currently being advocated today. Did you know that when a bear eats a fish he throws away the body? Could it be that the bear Figure: Essential fatty acids provided via wants the omega 6 provided PEOs work like magnets, drawing oxygen into cells and tissues. Reduce oxygen by the fish brain and not the content in cells by one third and they can omega 3 that is within its body? become cancerous.

(The fish uses omega 3 as an anti-freeze due to its cold water contains organically produced, environment). cold-pressed seed oils, these include high linoleic safflower PEO-Pro™ oil, sunflower oil, evening IAS has always been ‘on the primrose oil and flax oil, all in cutting-edge.’ It may remain the proportions derived from controversial, however we have Professor Peskin’s research. taken the decision to remove Maintenance doses are 1 or fish and krill based oils from 2 capsules daily; for those with our range and replace them greater need, 1 capsule per 40 with PEOs that are contained in lbs (18 Kg) bodyweight per day PEO-Pro™. may be more suitable.

The PEO-Pro™ supplement 2

2

2

Oxygen Magnets

Appetite

• Less Cravings • Less Hunger • Better Appetite Fulfilment

Heart Health

• Flexible Arteries • Clean Arteries • Fast Blood Flow • Lower Blood Pressure • Improves Lipids

Beauty

• Healthier Skin • Less Dandruff • Less Cellulite • Healthier Hair • Eczema Improved

• Less Sweet Cravings • Lower Blood Sugar • Less Neuropathy/ Retinopathy

PEOs

Anti-inflammation

SUPPORT

• Less Arthritis • Less Joint Pain/Swelling • Faster Healing

Hormones/ Endocrine

Brain Health

Endurance

Diabetes

• Better Sexual Function • Smoother Pregnancies • Less PMS • Fewer Headaches

• Better Clarity • Better Focus • Improved Memory • Helps Improve ADD & ADHD

• More Energy • Less Fatigue • Greater Intensity • Faster Recuperation

Figure: This diagram highlights the benefits of EFAs (essential fatty acids) that PEOs can deliver.

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SPOTLIGHT: PEPTIDE BIOREGULATORS THE DI SCOVERY OF G ENE SWITCHES IN FOOD Today Professor Vladimir Khavinson is the President of the European Academy of Gerontology and Geriatrics, but in the 1980’s he was a Colonel in the Soviet Union military medical corps. At the time, he and his team were approached by Kremlin officials, they wanted them to find a way to protect their troops from a myriad of problems; issues such as radiation for submariners in nuclear submarines to troops that may be blinded from known, (but thankfully unused) new weapons such as battlefield lasers.

A former Soviet military secret!

obtained from food, to act as a ‘short-cut’ to initiate protein synthesis. These peptides, What their research uncovered unlike proteins, can enter the - that was used for two blood through the stomach. decades on many thousands Through a comprehensive of men and women - was a list of patents and even remarkable link between copyrighted PowerPoint short chain peptides and DNA. slides, the Russian research This former military secret is group have shown that each now available to the public of the concentrated peptide as peptide bioregulators. bioregulators so far examined, Their published research has interact with particular strands identified that each organ / of DNA - effectively and very gland / tissue uses a highly specifically activating repair specific short chain peptide, and regenerative processes.

This is a remarkable story since what we are describing here are peptides that act as individualised gene switches. To date, they have been tested for many years on thousands Above: A short-chain peptide bioregulator

of individuals, without report of any serious side effects or contraindications. We believe that they could be set to ‘out do’ stem cells.

Why? Because this peptide therapy is relatively cheap, highly specific, can be taken orally and doesn’t require any suppression of the immune system to operate fully (as stem cells do).

Original material from the trials The peptide bioregulators available via IAS are the bovine originals; sourced from carefully chosen Danish calves and processed through pharmaceutical processes and filters. They are not the synthetic versions which have not been studied/ proven.

Peptide bioregulators act as they sound- to regulate; for example, Thyreogen®

the thyroid peptide would increase thyroid activity if it were too low, but decrease it if it were too high!

Dosing Doses are very dependent upon the need and unlike hormones these peptides do not have to be taken every day, hence making them a cost effective regime. A typical/ average use could be considered as follows: • Start with an intensive course: 2 capsules once a day for 30-days.

• Thereafter use 2 capsules once a day for 10-days, repeat every 2, 3, 4 or even as little as 6-months.

The story of the peptide bioregulators is a remarkable one and we recommend that you to read the articles and interviews and see the video on the IAS website.

interacting with DNA

PEPTIDES CURRENTLY AVAIL ABLE: Bone Marrow bioregulator: Parathyroid bioregulator: Brain peptide bioregulator: Heart peptide bioregulator: Bladder peptide bioregulator: Pineal peptide bioregulator: Adrenal peptide bioregulator: Muscle peptide bioregulator: Prostate gland peptide bioregulator: Kidney peptide bioregulator: Cartilage peptide bioregulator:

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Bonomarlot® Bonotirk® Cerluten® Chelohart® Chitomur® Endoluten® Glandokort® Gotratix® Libidon® Pielotax® Sigumir®

Pancreas peptide bioregulator: Stomach mucus peptide bioregulator: Liver peptide bioregulator: Lung peptide bioregulator: Testes peptide bioregulator: Thyroid peptide bioregulator: Blood vessel peptide bioregulator: Retina peptide bioregulator: Thymus peptide bioregulator: Ovary peptide bioregulator:

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

Suprefort® Stamakort® Svetinorm® Taxorest® Testoluten® Thyreogen® Ventfort® Visoluten® Vladonix® Zhenoluten®

SPOTLIGHT: CENTROPHENOXINE IMPROVES RECALL SPEED

C E NTRO PH E N OX I N E , (PRO N O U N C E D, C E NT- ROW- FE N - OX- I N) I S A C L A S S I C ‘ S M A RT D RU G .’

The term ‘smart drugs’ has become synonymous with substances that aid memory and cognition, although the correct medical terminology is ‘nootropics’ (which when translated from the Greek is- ‘towards the mind’). As shown in the insert, centrophenoxine is an ester of PCPA (a plant compound) and DMAE which is a natural choline-based substance found in the diet.

OCH2

Cl

A

PCPA

COO

CH2

CH2

N

CH3 CH3

DMAE

The molecular structure of centrophenoxine, showing its combination of PCPA and DMAE.

Background Centrophenoxine has been studied extensively over many decades, principally in Europe and one of its leading proponents is the Gerontology expert, Professor Imre Zs.-Nagy, whom utilises it for his own antiaging purposes, keeping his mind sharp.

later on), although the same could be said for all senile dementia medications, since trying to revert the damage of a mid-late stage dementia is very difficult. The target therefore is

be very troublesome for the cell because it inhibits proper functioning from taking place, reducing the transference of chemicals through the cell wall, thus damaging both messaging and detoxification abilities. Indeed this inhibition and the inherent loss of lipidity that accompanies it, forms a significant part of Professor Zs.-Nagy’s ‘membrane hypothesis of aging.’ What we do know, is that when significant amounts of lipofuscin are present

Professor Imre Zs.-Nagy says; “Centrophenoxine has shown many facets to improve conditions related to my membrane hypothesis of aging. For example, its ability to improve brain performance, survival time in animal experiments and to remove the cell-aging pigment called lipofuscin. It has been my antiaging supplement for more than 30-years.”

One of the actions of centrophenoxine is to improve acetylcholine levels in the brain and it is this neurotransmitter that declines in Alzheimer’s diseaseleading to its devastating effects.

Yet, centrophenoxine doesn’t make significant improvements for Alzheimer patients in this way, (note, there is another important action mentioned

Showing the typical size and placement of lipofuscin in tissues. at the earliest stage of dementia, or even before then, at the antiaging stage, wherein smartdrugs like centrophenoxine can improve/ enhance and protect the performance of an aging, but otherwise recognised as a healthy, individual.

Lipofuscin Lipofuscin is a waste material that accumulates in aging cells, especially those in the brain, heart, lungs and skin; indeed, in skin cells, lipofuscin can form part of the pigmented spots that are often referred to as ‘age’ or ‘liver’ spots.

Lipofuscin accumulation can

in the brain, they are then referred to as ‘plagues’ and then become recognised trait of Alzheimer’s.

Perhaps it is therefore centrophenoxine’s primary mode of action to help remove lipofuscin deposits. It does it so well, that it is currently believed to be the best tool commercially available to do so and so well, that in patients with visible ‘age’ or ‘liver’ spots in the skin; it is possible over several weeks of centrophenoxine supplementation to see them fade or even disappear. Such patients can also benefit from the knowledge, that at the same, lipofuscin deposits are being reduced in their heart, lungs and brain etc.

Centro-Pro™, the leading brand of centrophenoxine used by its expert, Professor Imre Zs.-Nagy and his patients.

General cognitive benefits Classifying the precise benefits of the various smart-drugs can be tricky. Most individuals often simply refer to their ailing cognitive facilities as “memory loss.” However, a quick breakdown of that statement requires further evaluation in order to determine the precise nature of the problem.

So which of the following is your main issue?

• Short term memory • Medium term memory • Long term memory • Do you get bored easily?

• Do you lack focus/ attention?

• Does your mind quickly become tired?

• Is the problem remembering new experiences later? (So called memory-imprinting) • Does it take too long time to recall memories?

Centrophenoxine is best suited to the last problem. If your speech appears to be full of “ums” and “ers” - whilst your brain tries to catch up with your mouth, then it is likely that centrophenoxine will be an aid for you. In our experience, centrophenoxine should not only be considered for those concerned with the development of Alzheimer’s, but when utilized correctly it can help many people, especially those aged over 40, to hasten their recall speed, bringing clarity and order to both speech and thought.

Doses It is of course impossible to list all details of centrophenoxine use onto one page, but interested parties should ask for further details and read the articles with references that are available on the IAS website. A typical dose for the ‘average’ person is 250 mg once or twice daily; higher doses are necessary according to the varying degrees of Alzheimer’s.

Note: Centrophenoxine is synergistic with other smart-drugs, in particular choline based forms such as piracetam (Nootropil®); these additional benefits can be experienced by using them concurrently, although naturally both doses need to be adjusted downward to suit.

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SPOTLIGHT: SMART DRUGS AND NUTRIENTS DEPR ENYL FOR FOCU S AND CONCENTR ATION Deprenyl is also known as selegiline, it was created in the 1960s by Professor Joseph Knoll from Hungary, principally as an aid to Parkinson’s patients - because deprenyl has a significant benefit to improve dopamine levels in the brain. Dopamine is the neurotransmitter most affected in Parkinson’s disease, in fact, deprenyl still remains a front line treatment for that disease.

Significant longevity studies

Morgenthaler, (as published in the book, Smart Drugs and Nutrients I), produced figure 2.

It highlights that the loss of dopamine in humans with age, can be mapped against both the development of Parkinson’s and even death.

Mode of action For a long time deprenyl has been expressed as a MAO-b inhibitor, that it to say that is prevents the enzyme monoamine-oxidase type-b from destroying dopamine, ergo leading to its greater availability in the brain. The inhibition of the more common MAO-a can be problematic, leading to something called ‘the cheese effect,’ therefore this is not a side effect of deprenyl, although it should be noted that dopamine can inhibit type-a, but usually only at very high doses of 20mg.

In more recent times, Professor Knoll has noted that there is another significant action of deprenyl and this is the raising, (albeit briefly) of PEA levels. PEA is a catecholamine activity enhancer that raises

Professor Joseph Knoll; now aged in his 90s but still active in pharmacological research.

Professor Knoll’s experiments with rats produced some of the most incredible longevity benefits that have ever been seen. When they were fed deprenyl in their food, they lived so much longer than those that were not, so much so, that even after the last non-treated rat died, the first of the deprenyl treated rats was yet to die! These results are shown in figure one: Note; interestingly and importantly, these results were verified independently in another study not conducted by Professor Knoll. Based on this research, Dean, Fowkes and

norepinephrine levels; this is a significant attention agent that is behind the primary mechanism of the famous Eugeroic drug- modafinil (Provigil®).

To learn a great deal more about dopamine and deprenyl, we would recommend Professor Knoll’s books; ‘the brain and its self’, or ‘how selegiline/ deprenyl slows brain aging.’

Typical patient responses In patients who have mild cognitive impairment, or age related minor cognitive dysfunction, the most common report is of a significant improvement in their focus and concentration.

Persons with higher dopamine levels often appear more ‘driven’ and ‘dedicated.’ Avoid overuse since it can lead to what may appear to be an oppressive behavior, as others around you are not so focused and ‘on the ball’ as you!

This is why we recommend occasional breaks from deprenyl use, some advocate one week off in the month and others use it during the

75

Dopamine Level (%)

% of animals alive

100

Deprenyl Treated Rats

50

Control Rats

25 0 140

150

160

170

180

190

200

210

220

Age of rats in weeks

Figure 1: Professor Knoll’s experiment showed that when deprenyl is given to animals it significantly extends their lifespan and their latter life activity.

36

100 90 80 70 60 50 40 30 20 10 0

Average Parkinson’s Patients Rapid Parkinson’s Patients

weekdays but not at the weekends.

Dosing Doses are as normal, based upon need and age. Whilst Parkinson’s patient will require large doses, a person wanting to improve their cognitive performance may want to typically consider 1mg to 3mg per day, with occasional breaks. Note: These doses do not take into account synergy with other dopamine enhancing agents and persons using anti-depressants should consult with their physician beforehand.

Deprenyl tablets are typically provided in 5mg form (Jumex®); some persons like to take ½ to 1 of these tablets 3-times a week; however the use of the deprenyl liquid (Dep-Pro™) is particularly attractive for those using deprenyl to generally support, protect and improve neurological function, since 1 drop = 1mg.

Therefore the liquid can be dosed very precisely by simply placing those drops into a cold drink. Avoid use in the late evening to prevent any sleep disruption.

Slow Aging People Normal People

PARKINSON’S SYMPTOMS DEATH 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140

Figure 2: For humans, the normal loss of dopamine past the age of 40 is 13% per decade. As the lines suggest, if we all live long enough we all become senile!

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SPOTLIGHT: SMART DRUGS AND NUTRIENTS PIR ACE TAM, THE ORIG INAL NOOTROPIC Smart drugs and nutrients, or to give them their correct medical terminologynootropics, are agents that can not only improve conditions of senile dementias, but in recent times have become popular for older individuals to improve their mental and cognitive processes. It was Ward Dean, M.D. who highlighted these facts through his very popular ‘Smart Drug’ series of books in the 1980s, since then the term ‘smart drugs’ has become mainstream.

Piracetam, the original nootropic The smart-drug we focus on here was in fact the first, developed as it was

by Dr. Giurgea for UCB laboratories in Belgium in the 1960s. Originally it was designed to assist with travel and altitude sickness, but shortly afterward individuals realised that piracetam had positive cognitive enhancement effects.

What can piracetam do for me?

Piracetam is a cognition agent that has been used successfully to treat a

wide range of conditions, for example it has been shown to increase a person’s attention levels and improve memory and intelligence. Piracetam can help to slow down ‘senile involution’, dementia and Alzheimer’s disease. In tests and trials, piracetam induces significant improvement to memory consolidation and recall in those suffering from ‘age-associated memory impairment’.

Piracetam has also been used to improve patient’s recovery from strokes, particularly improving post stroke speech impairment (aphasia). Another use has been in cases of acute and chronic cerebral ischaemia, (decreased blood flow to the brain). Using piracetam has restored speech and the use of limbs in these patients; it has also increased neuronal activity in the brain when measured with EEG.

For regular individuals, piracetam has been shown to enhance idea creation and the ability to ‘see things through,’ in other words to have ideas and bring them to fruition. The level of clarity piracetam creates is often described/ perceived as; “the fog has lifted.”

How does piracetam work?

Piracetam’s key and unique method of action is upon the Corpus Callosum, the region of the brain that links the two hemispheres.

It is this that most experts believe is the key that gives piracetam users the ability to channel greater brain potential by connecting the logical side of the brain with the creative side more effectively, Yin and Yang if you will.

“Piracetam can help to slow down ‘senile involution’, dementia and Alzheimer’s disease.”

What are the doses of piracetam?

A common dose is 800mg tablets three times a day, then lowering to 800 mg twice a day after the first month. Note: The effects of piracetam can be enhanced if taken concurrently with centrophenoxine or Hydergine®.

Side effects are minimal and seldom experienced, but should you experience nausea or headache then it is usually caused by an overdose, so in which case reduce the dose and build up more slowly, (if it is necessary).

Note: There are many articles and videos on the IAS website about smart drugs and nutrients.

Right: The Corpus Callosum

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37

SPOTLIGHT: STEM CELL WORX

®

ENHANCING AND IMPROVING STEM - CELL AC TIVIT Y Stem Cell Worx® is an intraoral spray that contains a very high-grade bovine colostrum, (with over 30% of the antibody IgG and over 54% protein) along with a 98% pure trans-resveratrol and 95% fucoidan (a seaweed extract). should not be confused with embryonic stem cells that come from an embryo.

The Stem Cell Worx® supplement is designed specifically to enhance one’s own adult stem cells naturally.

Stem Cell Worx® is an intraoral spray providing an absorption rate of up to 95% of its nutrients. This is important because in order for adult stem cells to be stimulated, it is the blood that is the principal carrier of nutrients and oxygen to our cells. In order to enhance cell activation you need three key factors, which are: • Growth factors • Immune factors and • Cytokines Stem Cell Worx® has all three of these factors in abundance and it is scientifically proven they are most effective when administered by intraoral spray delivery.

Time takes its toll on adult stem cells. At 65 years of age, the release rate of adult stem cells entering the bloodstream has dropped

1/10,000

Mesenchymal Stem Cells

Mesenchymal stem cells shown as a proportion of total cells in bone marrow.

Lots of MSCs in our younger years. MSCs repair muscle, bone cartilage and tendons.

MSCs rapidly decline with age.

Longer repair and recovery times. More prone to aging and disease.

1/100,000 1/250,000

Newborn

Teenager

Age 30

1/400,000

1/2,000,000

Age 50

Figure 1: The decline in stem cells with advancing age.

38

Age 80

90

% of Bone Marrow Cells Proliferated

This natural health supplement is designed to activate the body’s own adult stem-cells in order to provide a robust immunity. With 50 to 70 trillion cells in the body, cellular health is clearly crucial to overall well-being and good health. Hence, adult stem cells working at optimal levels provide the platform for many cumulative health benefits.

Unfortunately, as we age, our own adult stem cells decline rapidly, along with their release rates from the bone marrow, and our immune system weakens. Whilst stem cell clinics are at the forefront of antiaging medicine today, the process of full adult stem cell therapy is very expensive and has many regulatory restrictions.

Adult stem cells are the master cells of the body that have the ability to maintain, selfrenew and repair cells, tissue and muscle throughout an entire life-time. These cells are referred to as autologous, haematopoietic (blood), mesenchymal or stromal stem cells. Adult stem cells

80 70 60 50 40 30 20 10 0

25

12.5

6.25

3.12

Stem Cell Worx Concentration (mg/ml)

Figure 2: This study used blood samples from healthy humans. The adult stem cell proliferation percentages were determined by flow cytometry, measured in mgs of the Stem Cell Worx formulation. As this graph demonstrates the Stem Cell Worx formulation produces steady percentages of bone marrow stem cell proliferation being dose dependant, but still active at a relatively low dosage of mgs.

by 80% compared to youth.

It is important to keep them activated. The good news is it is now possible to reverse this statistic.

Stem Cell Worx® benefits Stem Cell Worx® contains the greatest number of natural growth and immune factors compared to any other health supplement currently on the market. This enables natural stem cell activation to be as much as 75% per 36mg of the formulation. This provides: • Support to naturally increase adult stem cells, providing the platform for many cumulative health benefits including: • Increased energy and endurance.

• Boosting the immune system.

• Improved alertness and mental clarity.

• Faster recovery after your

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exercise regime and faster repair and recovery after surgery, injury or illness.

• Helping to build muscle, burn fat and maintain natural weight loss in conjunction with a healthy diet and exercise regime.

IAS choose Stem Cell Worx® over other purported stem-cell activators on the basis of evidence. Figure 2 demonstrates the benefits of supplementing daily with Stem Cell Worx.

Dosing Six sprays into the mouth provide 36mgs of formulation.

This can be performed once or twice daily as required. Spray under the tongue, hold for 10 seconds, then swallow the remainder. It’s best taken on an empty stomach, at least 30-minutes before or after eating any food.

SPOTLIGHT: THYROID SUPPORT FOR THE HYPOTHYROID EPIDEMIC Dr. Broda Barnes in the 1970s estimated that 40% of the adult population was deficient in thyroid hormones; he published this statement in his excellent book‘hypothyroidism, the unsuspected epidemic.’ Since then, pupils of Dr. Barnes, such as Dr. Richard Wilkinson, have suggested that this figure could be even greater now!

This is important because the thyroid gland is of pivotal importance to our overall health, but like the majority of hormones as we age the production of thyroid hormones decline. This lack of thyroid function is the root cause of a wide variety of agerelated health disorders.

Ergo, supplementation with a synthetic or a natural thyroid can have a significant positive effect on a wide range of agerelated problems.

The importance of the thyroid gland The hormones produced by the thyroid control the body’s metabolism- the rate at which it burns calories for energy. It also controls the body’s utilization of fat, so a decline in the secretion of hormones from the thyroid gland, (known as hypothyroidism) can result in wide range of symptoms such as poor concentration, confusion, memory problems, cold hands and feet and weight gain.

Another serious condition which can be caused by and result from an underactive thyroid are painful musculoskeletal issues that affect tendons, muscles and ligaments.

How can I be sure if I need a thyroid supplement?

Above: The position of the thyroid gland

Apart from recognising the types of effects listed above, your doctor can of course get your blood

levels of thyroid checked, but another, simpler method is to take your body temperature when you wake in the morning.

It should be in the range of 97.8 to 98.2 degrees Fahrenheit, if it is regularly lower you could be hypothyroid and if higher then hyper-thyroid.

Choosing between synthetic and natural thyroid supplements IAS stocks a comprehensive range of both synthetic and natural thyroids, although we advocate the use of a natural supplement over a synthetic, this is because products such as Armour® are of a porcine origin, so they naturally contain the full spectrum of T1, T2, T3 and T4 thyroid hormones, (note the bottles only list the amounts of T3 and T4 because very few physicians are familiar with T1 and T2).

Conversion between synthetic and natural thyroid products The table provided is a helpful guide to what the suggested conversion rates are for those wishing to make the switch between synthetic thyroids and natural versions. As always we recommend consulting with a physician before making changes to your program.

Thyroid doses Natural desiccated thyroids are measured in grains; with one grain being equivalent to approximately 60 mg.

IAS carries doses from ¼ grain to 2 grains, with brands including Armour®, ERFA® and Nature®. IAS also provides synthetic T3 in 20 mcg and T4 in 100 mcg tablets.

Thyroid supplements provide potent antiaging protection Many aging individuals can benefit from taking a thyroid supplement because this remarkable hormone has such a profound affect across so many different conditions.

Many antiaging physicians consider thyroid support an essential part of any serious attempt to improve a person’s health-span and longevity.

Dose of Desiccated thyroid (grains)

Equivalents (mg)

Dose of T3 (lithyronine) (μg)

Dose of T4 (levothyroxine) (μg)

0.5

32

12.5

0.05

1

65

25

0.1

2

130

50

0.2 0.3

3

200

75

4

260

100

0.4

5

325

125

0.5

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39

SPOTLIGHT: YOUTH GEMS

®

THE PEP TIDE B IOR EG U L ATOR S FOR S KIN Four peptide bioregulators have now been combined into topical skin preparations so that their unique gene-switching performance can be bought to the field of aesthetic medicine.

What does each peptide provide for?

The beauty product line Youth Gems® contains the following four peptides and a ginseng extract called Neovitin®. They represent the very latest developed program of complex skin care designed for the face, neck, hands and the body.

The line includes four unique active ingredients of shortchain peptides that have a directed tissue-specific action to improve all basic skin structures: • Thymus peptide: This stimulates tissue regeneration and the synthesis of tissue-specific proteins. Thus, cells proliferative and metabolic activity is enhancedaccelerating the renewal of various cell tissues. It also has an anti-inflammatory action, improving the healing time of wounds, as well as antioxidant, immune stimulating and anti-stress actions.

• Pineal peptide: This regulates metabolic processes and increases protein synthesis in skin cells. It also possesses potent antioxidant activity, normalizes the lipid peroxidation processes in skin cells that in turn

40

promotes the elimination of negative influences on the skin from external factors.

• Cartilaginous peptide. This stimulates regeneration of fibroblasts and keratinocytes and interferes with the destructive changes in collagen skin structure; it also strengthens collagen structure of elastic skin fibers and increases elasticity.

• Blood vessel peptide: This regulates metabolic processes in the vascular wall, normalizes vascular tone and restores disturbed skin microcirculation. It strengthens and regulates the permeability of the vascular walls of skin vessels and improves skin turgor.

What else is included in Youth Gems® in addition to the four peptides?

In addition to the four peptides, the Youth Gems® also contain an incredible array of beneficial natural agents- which just by themselves would make other antiaging creams jealous! The range includes: Neovitin® (a complex isolated from ginseng), olive oil, raisin-seed oil, Argon oil, Soya oil, Jojoba oil, Bisabolol (extract from chamomile), Peony extract,

sodium hyaluronate (a derivative of hyaluronic acid), green tea extract, cocoa oil, carrageenan (from seaweed), winter bloom, almond extract and vitamin E.

What results have been seen?

Clinical trials and examinations have been conducted at the St. Petersburg Biogerontology Institute and they have concluded that these short chain peptides, when applied to skin cells, have many beneficial activities, shown below are some of those results. These include improved metabolism in vascular wall cells, the growth of new skin cells, enhanced antioxidant activity; increased blood flow circulation and greater moisturization.

The skin’s appearance becomes smoother, with fewer wrinkles and with more elasticity, all of which helps to lift the face contours producing a more radiant, youthful appearance. These beneficial effects were noted in 100% of women who took part in the voluntary clinica trial.

Right: A 68 year old female before (top) and after (below) application of Youth Gems®

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What’s available?

• Body milk: The body milk is a very light cream that can be applied to most areas of the body.

• Day cream: The day cream is the core product designed to be applied to the face and hands.

• Serum: The serum is designed to be used sparingly against the most noticeable skin aging effects on the face and neck.

• Tonic: This cleanser can be used to help any area become more firm and taught and may be splashed on as required.

All of the Youth Gems® should be applied onto clean, dry skin- avoiding the eyes; makeup can be applied after absorption - if required.

CONDITION CROSS-REFERENCE LIST This cross-reference list highlights individual products that have been used for these disorders.

Note: It does not mean that all these products are synergistic together.

Addison’s disease Aldosterone, peptide bioregulator (Glandokort®) ADHD (ADD, attention deficit disorder, see mental stimulants) Adrenal fatigue Aldosterone, hydrocortisone, peptide bioregulator (Glandokort®)

Rotational Melatonin Telomeres Peptide biomarker (Endoluten®), TA65® Anti-biotics Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline Anti-depressants Lithium, milnacipran (Ixel®), reboxetine (Edronax®), Stablon®, Valdoxan®, venlafaxine (Efexor®)

AGE (advanced glycated end-product inhibitors) ACF228™, aminoguanidine, Can-C™ Plus, carnosine, metformin, pyridoxamine

Anti-oxidants (see free radical scavengers)

Age Related Macular Degeneration (see eyesight)

Anxiety (see stress)

Age Related Mental Decline (see cognitive)

ARMD (see eyesight)

Aids (see HIV)

Arterial (See heart, arterial & blood)

Alcoholism (also see compulsive disorders) 5HTP, L-tryptophan, memantine

Arthritis (rheumatoid & osteo) Andro-Pro™, Gerovital-H3®, Novisyn®, PEO pregnenolone, SAMe, thymus,

Allergies Pregnenolone, thymus

Asthma (see Allergies)

ALS (amyotrophic lateral sclerosis, Lou Gehrig’s disease) Naltrexone, TRH

Autism (also see chelation agents) Oxytocin, piracetam

Alzheimer’s disease (see senile dementia)

Back problems (see spine)

Anabolic (see growth hormone & testosterone)

Bell’s palsy Vitamin B12

Anginas (see heart, arterial & blood)

Blood disorders (see heart, arterial & blood)

Animal use Can-C™ eye-drops, deprenyl, L-tryptophan, peptide bioregulators

Blood pressure Magnesium, Neo40®, oxytocin, potassium, propranolol, vinpocetine

Antiaging (as impacting on a particular theory of aging) Calorie Restriction Carnosine, metformin, resveratrol

Bone problems (also see joints & arthritis) AndroPro™, Bone-Pro2™, Esnatri™, peptide bioregulator (Bonomarlot®), progesterone, SAMe, thyroid

Free radical ACF228™

Breathing (see lungs)

Glycation Aminoguanidine

Membrane Centrophenoxine

Cancer (also see anti-oxidants & radiation) 1st Line™, anastrozole, BEC5® Curaderm, bromocriptine, curcumin, DIM-Pro2™, melatonin, metformin, naltrexone, oxaloacetate, progesterone, resveratrol, thymus, TRH

Mitochondrial Hydergine®, PQQ

Cardiovascular (see heart & arterial disorders)

Neuroendocrine Metformin, TRH

Cataplexy (sudden fatigue) Adrafinil, picamilone

Hayflick Carnosine, TA65®

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Cataract (see eyesight)

Diabetes insipidus (see urination)

Central Nervous System (CNS)

Dieting (see weight loss)

Peptide bioregulator (Cerluten®)

Digestive issues peptide bioregulator (Stamakort®), Symprove®

Chelation agents Carnosine, centrophenoxine, EDTA, zeolite Cholesterol (see blood disorders) Crohn’s disease Naltrexone Chronic fatigue syndrome (see mental stimulants & physical energy improvement) Cognitive (also see memory & senile dementias) Alertness Adrafinil, Xan-Pro™ Creativity Aniracetam, piracetam, pramiracetam Focus/ concentration Deprenyl, desmopressin, vasopressin Energy ATP-Boost™, centrophenoxine, Mito-Pro2™, picamilone General support Gerovital-H3®, vinpocetine

Down’s syndrome Melatonin, piracetam Energy improvement (see physical energy & mental stimulants) Enzymes Boluoke® Epilepsy GABOB, phenytoin Erectile dysfunction (also see sex-libido & premature ejaculation) Andro-Pro™, cabergoline, deprenyl, Neo40®, oxytocin, Vielight® Eyesight ARMD MZS™ Cataracts Can-C™, Can-C™ Plus Contact lenses Can-C™

Intelligence Hydergine®

Dry eyes Can-C™

Work load Hydergine®, thyroid

General support Aminoguanidine, peptide bioregulator (Visoluten®), vinpocetine

Compulsive disorder treatment (also see alcoholism) 5HTP, GABOB, L-tryptophan, picamilone Cortisol alteration (also see stress) Aldosterone, DHEA, GABOB, Gerovital-H3®, hydrocortisone, peptide bioregulator (Glandokort®), phenytoin Cross linking (see AGE) Deep vein thrombosis (see frequent fliers) Dental (see teeth & gums) Depression (also see well-being & anti-depressants) 5HTP, aniracetam, ATP-Boost™, curcumin, deprenyl, Gerovital-H3®, lithium, L-tryptophan, milnacipran, picamilone, piracetam, pramiracetam, pregnenolone, SAMe, thymus, thyroid DHT alternation (dihydrotestosterone) Dutasteride, finasteride, peptide bioregulator (Libidon®), progesterone Diabetes Acarbose, aminoguanidine, ATP-Boost™, benfotiamine, L-carnosine, metformin, Mito-Pro2™, PEO, peptide bioregulator (Suprefort®), pyridoxamine, thyroid, TRH 42

DNA support (also see telomeres) Carnosine, CoQ10, PEO, peptide bioregulators, PQQ, resveratrol, TA65®

Glaucoma Can-C™ Retinal MZS™, nicergoline, picamilone Retinal pigmentosa Picamilone, peptide bioregulator (Visoluten®) Excitotoxins (reduction) Carnosine, deprenyl, idebenone, lithium, memantine Fertility Melatonin, metformin, peptide bioregulator (Zhenoluten®), TRH Fibromyalgia (also see physical energy & mental stimulants & pain relief) 1st Line™, milnacipran, naltrexone, oxytocin Free radical scavengers ACF228™, ATP-Boost™, BHT, glutathione, idebenone, melatonin, Mito-Pro2™ Gastrointestinal (see digestive) Glaucoma (see eyesight) Glucose control (see diabetes) Glycation prevention (see AGE)

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Gout Colchicine

HGH (see growth hormone)

Growth hormone (improvement) Bromocriptine, deprenyl, GABOB, GHRP2, GHRP6, Hydergine®, Neo40®, sermorelin, thymus, thyroid

Homocysteine (see heart, arterial and blood)

Hashimoto’s Iodine, peptide bioregulator (Thyreogen®), thyroid Hair improvement Dercos®, dutasteride, finasteride, Gerovital-H3®, PEO

HRT (hormone replacement therapy for women) DHEA, Esnatri™, melatonin, progesterone Human growth hormone (see growth hormone) Hypertension (see blood pressure)

Headaches (see migraines)

Hypothyroidism Iodine, peptide bioregulator (Thyreogen®), thyroid

Heath diagnostics (see at home test kits)

IBS (irritable bowel syndrome) Symprove®

Hearing disorders Aldosterone, Anacervix®, nicergoline, picamilone, vinpocetine

Immune system improvement (also see infections) 1st Line™, ATP-Boost™, carnosine, melatonin, peptide bioregulator (Vladonix®), peptide bioregulator (Thyreogen®), resveratrol, thymus, thyroid

Heart, arterial & blood (includes blood markers) Arteries (hard) Aminoguanidine, Bio-CUFF™, carnosine, resveratrol Blood pressure (high) Magnesium, Neo40®, potassium, propranolol, vinpocetine Calcium Peptide bioregulator (Bobothyrk®)

Infections (also see immune system improvement, antibiotics & influenzas) 1st Line™, beta-glucans, fluconazole, silver Inflammation (reduction) Boluoke®, curcumin, PEO, pregnenolone, thymus

Cholesterol (high) CoQ10, Gerovital-H3®, TRH, Xan-Pro™

Influenzas (also see anti-biotics, infections & immune system improvement) 1st Line™, beta-glucans,

Dilation (nitric-oxide) Deprenyl, Neo40®, Vielight®

Injectable products Gerovital®, vitamin B12

Fibrinogen Curcumin, TRH

Insulin & glucose control (see diabetes)

General support CoQ10, PEO, peptide bioregulators (Chelohart® & Ventfort®), PQQ, vinpocetine

Intestinal flora (see probiotics)

Glucose (high) Acarbose, metformin, TRH Glycated end-products ACF228®, aminoguanidine, metformin Heart pulse (irregular) ATP-Boost™, thyroid Heavy metals (chelate) EDTA, zeolite

Intra-ear products Aldo-Spray™ Intra-nasal products Desmopressin, GHRP6 (ReleasePro™), vasopressin, Vielight® Joints (also see bones & arthritis) Boluoke®, Novisyn®, PEO, peptide bioregulator (Sigumir®), pregnenolone, SAMe, thymus Kidney disorders (also see infections) Aminoguanidine, peptide bioregulator (Pielotak®) SAMe, TRH

Homocysteine TRH Lipofuscin Centrophenoxine

Learning (also see memory & mental stimulants) Aniracetam, desmopressin, Hydergine®, piracetam, pramiracetam, vasopressin

Plaques (clots) Boluoke® Triglycerides Curcumin, PEO, TRH

Libido (see sex)

Hepatitis (see liver and infections) Herpes (also see anti-biotics) 1st Line™, ACF228™, BHT, silver HIV (also see immune system improvement) 1st Line™, melatonin, naltrexone, thymus

Lipids (see blood disorders) Liver disorders (also see infections) CoQ10, idebenone, peptide bioregulator (Svetinorm®), pregnenolone, SAMe, silver

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43

Longevity enhancement (significant lifespan increases seen in animal studies) Centrophenoxine, deprenyl, melatonin, peptide bioregulator (Endoluten®) vasopressin

Nitric Oxide release Neo40®, Nitric Oxide saliva test strips, Vielight®

Lou Gehrig’s disease (see ALS)

Osteoporosis (see bone problems)

Lungs ACF228™ Breathe-Easy, centrophenoxine, glutathione, peptide bioregulator (Taxorest®)

Pain relief (general) ATP-Boost™, Gerovital-H3®, memantine, milnacipran, nicergoline, oxytocin

Lupus Milnacipran, naltrexone

Parasites (see infections)

Lyme’s 1st Line™, beta-glucans, silver

Parkinson’s disease (see senile dementia)

Macular degeneration (see eyesight)

Pets (see animal use)

Malaria (see anti-biotics)

Photoaging (see skin problems)

Menopause (see HRT)

Ph balance (rebalancing) Symprove®

Mental stimulants (also see physical stimulants) Adrafinil, aniracetam, centrophenoxine, deprenyl, desmopressin, nicergoline, picamilone, piracetam, pramiracetam, vasopressin, Xan-Pro™

Physical energy improvement (also see mental stimulants) ATP-Boost™, carnosine, CoQ10, idebenone, Mito-Pro2™, NADH, oxaloacetate, PQQ, pregnenolone, SAMe

Memory (also see cognitive & senile dementia)

PMS (pre-menstrual syndrome) PEO, peptide bioregulator (Zhenoluten®), vinpocetine

General support PEO, picamilone, vinpocetine Imprinting (for later recall) Desmopressin, vasopressin

Premature ejaculation/ ejaculate (also see erectile dysfunction & sex-libido) Oxytocin

Medium-long term Hydergine®

Probiotics Symprove®

Short term Aniracetam, piracetam, pramiracetam

Prostate (also see cancer) DIM-Pro2™, dutasteride, finasteride, melatonin, peptide bioregulators (Chitomur® & Libidon®), Prostate-Pro2™

Speed of recall Centrophenoxine Methylation (conversion of one chemical into another inside the body) ATP-Boost™, Boluoke®, Mito-Pro2™, SAMe, Xan-Pro™ Migraines (also see pain relief) Nicergoline, memantine, picamilone, vitamin B12 Mitochondrial support ATP-Boost™, CoQ10, deprenyl, glutathione, Hydergine®, idebenone, Mito-Pro2™, NADH, oxaloacetate, PQQ, pregnenolone, SAMe Mtor inhibitors Curcumin, oxaloacetate, resveratrol Multiple Sclerosis (also see mitochondrial support) Melatonin, naltrexone, TRH Muscles (see sarcopenia) Nail condition Gerovital-H3®, PEO Narcolepsy (sleeping in the daytime) Adrafinil, melatonin, picamilone

44

Oral health care (see teeth & gums)

Prolactin alteration Bromocriptine, cabergoline, GABOB PSA (prostate specific antigen- see prostate) Urination (frequent) Peptide bioregulator (Chitomur®), vasopressin RNA (see DNA support) Sarcopenia (muscle atrophy/ wastage) GHRP2, GHRP6, peptide bioregulator (Gotratix®), sermorelin Senile dementia (also see cognitive & memory) Alzheimer’s Centrophenoxine, curcumin, galantamine, Hydergine®, memantine, nicergoline General support Anacervix®, aniracetam, PEO, piracetam, pramiracetam, vinpocetine, Parkinson’s Bromocriptine, cabergoline, deprenyl, NADH, rasagiline

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Senility Gerovital-H3®

Sublingual products Oxytocin, sermorelin, TRH

Sex (libido, also see erectile dysfunction & premature ejaculation) Andro-Pro™, deprenyl, MSH, oxytocin

Sunburn (see skin problems)

Skin problems (also see herpes and tanning)

Syndrome X (metabolic syndrome) Aminoguanidine, ATP-Boost™, melatonin, metformin, Mito-Pro2™, PEO

Acne Beta-glucans

Tanning (darkening the coloration of skin) MSH

Age (liver) spots Centrophenoxine

Teeth & gum disorders Doxycycline, Min-Mouth™ mouthwash, NeyDent® toothpaste, silver, zeolite

Anti-glycation Aminoguanidine, carnosine, Youth Gems® serum Anti-oxidant Youth Gems® day cream Cancer (non-melanoma) BEC5® Curaderm Cellulite Youth Gems® body milk

Telomeres (also see DNA support) Carnosine, PEO, peptide bioregulator (Endoluten®), TA65® Testosterone & testes (also see fertility and prostate) Anastrozole, Andro-Pro™, DIM-Pro2™, melatonin, oxytocin, peptide bioregulator (Testoluten®), TRH, zinc Topical products BEC5®, beta-glucans, Can-C™ eyedrops, Esnatri™, progesterone, silver, Youth Gems®

Collagen Novisyn® Environmental Youth Gems® serum

Triglycerides (see blood disorders)

General support Gerovital-H3®, melatonin, PEO, thyroid

Veterinarian (see animal use)

Infections Silver, thymus

Weight gain (muscle mass) Andro-Pro™, GABOB, GHRP6, sermorelin

Moisturizer Youth Gems® day cream Psoriasis Beta-glucans Sun spots (keratosis) BEC5® Curaderm Wounds Silver

Weight loss (appetite suppressants and fat burners) 5HTP, acarbose, aminoguanidine, ATP-Boost™, DIMPro2™, galantamine, GHRP2, L-tryptophan, metformin, Mito-Pro2™, MSH2, thyroid, TRH, Xan-Pro™ Well-being (also see depression) 5HTP, aniracetam, ATP-Boost™, deprenyl, Gerovital-H3®, L-tryptophan, melatonin, Mito-Pro2™, PEO, picamilone, piracetam, pramiracetam, SAMe, thymus, thyroid, zeolite

Sleep disorders For less sleep Adrafinil, ATP-Boost™ For more sleep 5HTP, gabapentin, L-tryptophan, melatonin Smoking cessation 5HTP Spine issues (also see growth hormone) Novisyn®, peptide bioregulator (Sigumir®) Sports (see growth hormone, estrogen alteration, physical energy & testosterone) Stem Cells Stem Cell Worx® Stress (also see cortisol) 5HTP, GABOB, Gerovital-H3®, L-tryptophan, melatonin, oxytocin, picamilone, phenytoin, pregnenolone, propranolol Stroke Anacervix®, aniracetam, Boluoke®, Hydergine®, idebenone, nicergoline, PEO, picamilone, piracetam, PQQ, pramiracetam, pregnenolone, vinpocetine Stomach (see digestive)

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

45

A-Z INGREDIENT LIST The following list is intended to highlight the key ingredients in some products and cross reference them to the most relevant product brand names.

Note: Those products with the same name as the ingredients are not shown here as they are within the A-Z product list.

If you want this-

5HTP

Buxamin (GABOB)

Gamibetal®

Acetyl-L-Carnitine (ALC)

ATP-Boost™, Vigor-Pro2™

Caffeine

Minox-Pro™

Adenosine triphosphate (ATP)

ATP-Boost™

Calcium

Bone-Pro2™

Carboxymethylcellulose

Can-C™

Aglomelatine

Valdoxan®

Catalase

ACF228™

Allicin (garlic)

EDTA-Pro™

Chelation agents

Alpha lipoic acid (R-lipoic acid)

ATP-Boost™, Mito-Pro2™

Carnosine, centrophenoxine, DMSA, EDTA-Pro™, zeolite

Aminexil

Dercos®

Choline

Centrophenoxine

Amino acids (includes di-peptides)

5HTP, ACF228™, ATPBoost™, carnosine, L-tryptophan, Mito-Pro2™

Chromium polynicotinate

ACF228™

Citrulline

Neo40®

Aminohydroxybutyric acid (GABOB)

Gamibetal®

Co-dergocrine mesilate

Hydergine®

Coenzyme Q10

CoQ10, Mito-Pro2™

Aminosyn

Hair-Pro™

Colloidal Silver

Silver

Anti-biotics

Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline

Colostrum

Stem Cell Worx®

Cortisol (cortisone)

Fludrocortisone, hydrocortisone

Lithium, milnacipran, moclobemide, reboxetine, Stablon®, Valdoxan®, venlafaxine

Cranberry extracts

Andro-Pro™

Creatine

Mito-Pro2™

Cresote bush

ACF228®

Anti-oxidants

See free radical scavengers,

Cycloastragenol

TA65®

Arginine

Mito-Pro2™

Cyclodextrin

Arimidex®

Anastrozole

CoQ10-SR™, Curcumin-SR™, resveratrol

Astragalus extracts

TA65®

Dehydroepiandrosterone

DHEA

Azelaic acid

Minox-Pro™

Detox

Azilect®

Rasagiline

DIM-Pro2™, EDTA-Pro™, zeolite

Benzoic acid

Gerovital®

DHA (docosahexaenoic acid)

PEO-Pro™

Beta blocker

Propranolol

Diapid®

Vasopressin

Beta alistine

Carnosine, ACF228®, Can-C™, Can-C Plus™

Di-IndolylMethane (DIM)

ACF228™, DIM-Pro2™

Beta glucan

BG-Cream™, BG-Pro™

Dilantin®

Phenytoin

bFGF

Hair-Pro™

BHT (butylhydroxytoluene)

ACF228™, BHT-Pro™

Blueberry extracts

Andro-Pro™

DMSA (dimercaptosuccinic ACF228™, DMSA-Pro™ acid)

Borate

Andro-Pro™, Can-C™

D-pantethine

Boron

Andro-Pro™

Anti-depressants

46

look for:

5-hydroxy-tryptophan

DMAE (dimethylaminoeth- Centrophenoxine anol)

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

Can-C Plus™

Dr. Dean’s recommendations

Acarbose, centrophenoxine, CurcuminSR™, Hydergine®, metformin, piracetam, Xan-Pro™

Synthetic: Desmopressin, Eutirox® thyroid, fludrocortisone, hydrocortisone, T3-Pro™

Dr. Pierpaoli’s recommendations

Melatonin, TRH

Dr. Wright’s recommendations

DHEA, Esnatri™, progesterone

Supporting agents: DIMPro2™, GHRP2, GHRP6, peptide bioregulators, SAMe, sermorelin

Ebixa®

Memantine

EDTA (ethylene diamine tetraacetic acid)

EDTA-Pro™

Eldepryl®

Deprenyl

Electrolytes

Volt-Pro™

Enzymes

Boluoke®

EPA (eicosapentaenoic acid)

PEO-Pro™

Ergoloid mesylate

Hydergine®, nicergoline

Estrogens (estradiol, estriol, Esnatri™ estrone) Finasteride

Hair-Pro™

Florinef®

Fludrocortisone

Folic acid (folate)

ACF228™, DIM-Pro2™§

Free radical scavengers

ACF228™, ATP-Boost™, BHT, glutathione, idebenone, melatonin, Mito-Pro2™, pyritinol

Fructoborate

Andro-Pro™

Fucoidan

Stem Cell Worx®

GABA (gamma-aminohydroxybutyric acid)

picamilone

GABOB

Gamibetal®

GHRP6

Release-Pro™

Ginseng

Youth Gems®

Glucophage®

Metformin

Glutathione

ACF228®, ACG

Glycerine (glycerin)

Can-C™

Glycosides

BEC5 Curaderm®

Hawthorne Berry (crataegus)

Neo40®

HGH (human growth hormone/ somatropin)

GABOB, GHRP2, GHRP6, sermorelin

Hormones (includes Bio-identical: Aldosterone, hormonal support supple- DHEA, Esnatri™, melatonin, ments) MSH, oxytocin, pregnenolone, progesterone, TRH Natural (animal): Armour® thyroid, ERFA® thyroid, Nature® thyroid, thymus, vasopressin

HRT (hormone replacement therapy for women)

DHEA, Esnatri™, melatonin, progesterone

Hyaluronic acid (hyaluronan)

Hair-Pro™, Novisyn®

Hydergine (ergoloid mesylates)

Hy-Pro™

IGF-1 (insulin like growth factor one)

IGF-1 (LR3)

Indol-3-Carbinol (I3C)

DIM

Iodide/ Iodine Ixel® Ketoconazole L-arginine L-carnitine L-carnosine

ACF228™, Iodine-Pro™ Milnacipran Nizoral® Mito-Pro2™ Mito-Pro2™ Carnosine, ACF228®, Can-C™, Can-C Plus™ Neo40® Can-C Plus™ ATP-Boost™, Mito-Pro2™

L-citrulline L-histidine Lipoic acid (includes R-lipoic acid) L-methione Lucidril® Lumbrokinase Magnesium

Malic Acid Manganese Meclofenoxane Melanocyte stimulating hormone Mild Silver Protein Milk protein Minerals (general) Minoxidil N-acetylcarnosine N-acetylcysteine Namenda® Neurontin® Nettle root extract Niacin (nicotinate, niacinamide, vitamin B3) Nicotinamide adenine dinucleotide

ACF228™, Can-C Plus™ Centrophenoxine Boluoke® Andro-Pro™, Bone-Pro2™, Magnesium-Pro™, Mito-Pro2™ EDTA-Pro™ Mito-Pro2™ Centrophenoxine MSH2 Silver Bone-Pro2™ Min-Mouth™ (mouthwash), Volt-Pro™ Minox-Pro™ Can-C™ ACF228™, Can-C™ Plus Memantine Gabapentin Prostate-Pro2™ Picamilone, Xan-Pro™ NADH, PQQ

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

47

Nootropil®/ Nootropyl® Nordihydroguaiaretic acid (NDGA) Omega 3 (DHA) Omega 6 (linoleic acid, GLA) Omega 9 (oleic acid) Oxythiocynate (OCSN) Parent Essential Oils (PEO) PABA (para-aminobenzoic acid) Panthenol (pantothenic acid) PCPA (paarachlorophenoxyacetic acid) Pepermint Oil Peptides

Pimagedine Pomegranate extracts Potassium Prasterone Propionyl-L-carnitine Probiotics Procaine (Novocain®) Pygeum africanum Pyroloquinoline quinone Red clover herb extracts Reminyl® Resveratrol Retinolic acid (tretinoin) Ribonucleic acids (RNA) Salicylic acid S-Adenosyl-L-Methionine Saw palmetto (Serena Repens) Selenium

Seligiline Silver Solasodine glycosides Thiocynates

48

Piracetam ACF228™

Thyroids

PEO-Pro™ PEO-Pro™ PEO-Pro™ 1st Line™ PEO-Pro™ Gerovital® Mito-Pro2™ Centrophenoxine Min-Mouth™ mouth rinse GHRP2, GHRP6, peptide bioregulators, sermorelin, TRH, Youth Gems® Aminoguanidine Andro-Pro™ Gerovital®, Potassium-Pro™ DHEA Vigor-Pro2™ Symprove® Gerovital® Prostate-Pro2™ PQQ Prostate-Pro2™ Galantamine Resveratrol-SR™, Stem Cell Worx® Retirides® NeyDent® toothpaste BEC5 Curaderm®, Sol Answer™ SAMe MinSaw™, Prostate-Pro2™

Natural brands: Armour®, ERFA®, Nature® Synthetic brands: Eutirox® (T4), T3-Pro® (T3) Supporting agents: Peptide bioregulator (Thyreogen®) TRH

Thyrotropin releasing hormone Tribulus terrestris TRX Turmeric

Andro-Pro™ Hair-Pro™ Curcumin

Ubiquinone, ubiquinol

CoQ10

VEGF Vincamine Vinpocetine Vitamin B1 (thiamine) Vitamin B2 (riboflavin) Vitamin B3 (niacin, niacinamide) Vitamin B6 (pyridoxal, pyridoxine) Vitamin B12 (cobalamin) Vitamin C (ascorbic acid) Vitamin E (tocopherols)

Hair-Pro™ Anacervix® Vin-Pro™ Mito-Pro2™ Mito-Pro2™ Mito-Pro2™, Picamilone, Xan-Pro™ ACF228™, Andro-Pro™, DIM-Pro2™, pyridoxamine DIM-Pro2™, Neo40® MinSaw™, Neo40® Can-C Plus™, DIM-Pro2™, Prostate-Pro2™ Bone-Pro2™

Vitamin K2 (menatretrenone) Yohimbine Zeolite Zinc

ACF228™, DIM-Pro2™, MZS™, Prostate-Pro2™, Selenium-Pro™, Thym-Uvocal® Deprenyl ACS®, Min-Mouth™ mouth rinse BEC5 Curaderm®, Sol-Answer™ 1st Line™

www.antiaging-systems.com • Order hotline: 1-866-800-4677 • e-mail: ias@antiaging-systems.com

Vigor-Pro2™ ACZ® Andro-Pro™, Can-C Plus™, Mito-Pro2™, MZS™, Thym-Uvocal®, Zinc-Pro™

www.antiaging-hormones.com Specialists in natural, synthetic and bioidentical hormones

Thyroids

Melatonin

Aldosterone

Oxytocin GHRP2 Estrogen Sermorelin

TRH Progesterone Vasopressin

NOW SHIPPING TO THE EU

IAS are delighted to announce the launch of our exciting new website www.antiaging-hormones.com, placing IAS ďŹ rmly on the map in leading the supply of Hormones to EU and EEA countries.

TESTIMONIALS NICE COMMENTS FROM NICE PEOPLE

Dr. Aubrey De Grey “IAS has shown great vision and

Garry Gordon, MD, DO, MD (H)

Jonathan Wright, M.D.

“I am a 77 year old Physician

“Every adult has the right to take

Nicholas Perricone, M.D. “IAS is an outstanding resource

leadership, as an organisation

who has practiced medicine

care of his or her own personal

for the finest, most up-to-

focused mainly on the

for nearly half a century.

health as he or she chooses.

date news and information

provision of contemporary

My antiaging research has

In the 20th and 21st centuries,

on healthy aging. They also

medical interventions against

permitted me to overcome

this universal human right

offer products of the highest

aging, and in also supporting

serious health problems.

has been nearly obliterated

integrity and efficacy. In fact,

the SENS Foundation’s efforts

Everyone can do this, but it

by an ocean of nanny-state

IAS is the world’s greatest

to hasten the development of

requires specialized knowledge

regulation and deliberate

source (often the only source)

much more powerful future

and the highest quality

suppression of information by

for the most cutting edge and

interventions.”

products. IAS is a vital link in

bureaucracies, with hidden

advanced nutrients to ensure

my antiaging program because

and not-so-hidden agendas.

optimum health span and maximum life span.”

they continually provide both

International Antiaging

accurate information AND the

Systems is a beacon of useful

high quality products we all

health care information and

require, if we are to achieve

a literal island of freedom of

our maximum intended

health care product choice in

useful lifespan.”

our otherwise un-free health care world.”

Thierry Hertoghe, M.D.

“IAS is one of the pioneering societies in antiaging medicine...”

Thierry Hertoghe, M.D.

“IAS has a history of making throughout the world crucial, but difficultly accessible medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has

See all professional and public testimonials at: www.antiaging-systems.com/content/11-testimonials

50

www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

helped this new medical specialty move forward.”

PAYMENT OPTIONS ACROSS THE IA S WEBS ITES…

PAYMENT OPTIONS AND CONTACT DETAILS The IAS Group offers a wide range of payment options to make the completion of your order as easy as possible.

Payment options for www.antiaging-systems.com:

Other sites in the IAS Group www.antiaging-nutrition.com, www.iasjapan.com, www.antiaging-peptides.com, www.antiaginghormones.com and www.antiaging-nootropics.com accept the following method of payments:

Pay by VISA credit card

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Use an electronic check via CHECK2PAY

Pay by VISA

(US banks only) BANK WIRE

Pay by MASTERCARD

Pay via Bank Wire

Pay by American EXPRESS

Pay by Debit Way

DEBIT CARDS

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Pay by Debit Cards

WEBSITES www.antiaging-systems.com www.antiaging-nutrition.com www.antiaging-nootropics.com www.antiaging-peptides.com www.antiaging-hormones.com www.IASjapan.com

(all of our products in one place; English language) (our nutritional products; English language) (our smart drugs and nutrients; English language) (our peptide bioregulators; English language) (our hormones; English language) (our nutritional products; Japanese language)

EMAIL ias@antiaging-systems.com iasjapan@antiaging-systems.com

(English language) (Japanese language)

PHONE USA: 1-866-800-4677 (orders only) Japan: 050-553-29606 UK: 0208-123-2106 ROW: +44-208-123-2106

1-415-992-5563 (enquiries)

Please note: Our customer care team is available from 9am till 6pm GMT Monday-Friday.

Outside of these times your call will be handled by our out-of-hours answering service or go to voicemail.

MAIL Unfortunately personal checks and money orders cannot be accepted at this time.

Please contact our customer service team if you need any assistance in placing your order.

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51

GROWTH HORMONES WITHOUT THE INJECTION Save up to $20 on GHRP2, GHRP6 & Sermorelin GHRP2™ $149.99 (save $10.00 over regular price) ONLINE CODE: GHRP2-10-OFF-AMM4

GHRP6™ $64.99 (save $10.00 over regular price) ONLINE CODE: GHRP6-10-OFF-AMM4

Sermorelin™ $179.99 (save $20.00 over regular price) ONLINE CODE: SERMO-20-OFF-AMM4

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

Offer valid until 2nd September 2016.