Lakisha Johnson
PORTFOLIO
Walters & Wray Collateral print Client | Two entrepreneurs starting a new concierge service company.
Objective
Develop a dynamic, unified design scheme and style to use in business cards, letterhead, note cards and other printed material, based off of the form & spirit of the client’s existing logo design.
Results
Created three style options. Clients chose the blue sunburst theme to portray a combined feeling of energy and professionalism.
12 Days: A Countdown to Christmas print Client | None (Personal Project)
Objective
As it is every year, the objective was to develop an out-of-the-ordinary, handmade Christmas Card that the recipients can interact with.
I nspiration
When I was younger, my mother would give me a chocolate advent calendar every December. I remembered how fun it was to open up everyday, and wanted to recreate that feeling of receiving a small “gift� each day leading up to Christmas... sans the chocolate.
Sysco Produce Flyers print Client | Sysco Indianapolis, LLC: A Food Distribution Company
Objective
Develop a modern aesthetic for the company’s weekly produce price flyers that is engaging and informative to the customer.
Results
The previous flyers had the same format, outdated background image and produce photos for years. I developed new graphic themes each week, based on the title given to the corresponding week’s flyer as well as photographed or used new sources for more clean, sharp produce imagery. The new flyers are easier-to-read, better-looking and more interesting to the customers than in the previous format.
Boarding Pass Invitation print Client | Walters & Wray
Objective
Develop a modern theme for a trendy, jet-setting woman’s 50th surprise birthday party and incorporate this theme into supporting materials. This invitation was one of those pieces.
Results
After brainstorming with the client on possible travel-based themes, we narrowed it down to using a map theme and boarding pass style for the invitation and subtly highlighting some of the different places that the woman had most enjoyed. Other materials created for this event include a Save the Date postcard and a wine bottle label.
King’s Kids Projects print Client | Eagledale Baptist Church King’s Kids Program
King’s Kids Club WHAT IS THE KING’S KIDS CLUB?
The King’s Kids Club is a character building and Bible memory oriented program for boys and girls 4 years of age through the 6th grade. Every King’s Kids Club night is an exciting, action-packed evening that focuses on reaching children with the gospel and teaches them how to live for Jesus Christ.
Eagledale Baptist Church
th 4950 W. 34King’s Street Indianapolis, IN 46224 Kids clubbers each have a uniform and will earn awards 317-291-4783 www.eagledalebaptist.org to be•displayed on the uniform to indicate their achievements
throughout the year. Each club night includes an organized Game Time, Counsel Time, and Handbook Time. The club meets on Wednesday evenings from 6:45 pm to 8:30 pm. The men and women that serve as leaders in the King’s Kids Club each week are faithful members of Eagledale Baptist Church who love serving the Lord and enjoy seeing boys and girls learn and grow in their knowledge of the Lord.
Game Time Game Time: A time in which the clubbers can have a lot of fun while still bringing honor to the Lord. Game Time includes many different activities that help children develop team spirit and cooperative skills.
Counsel Time Counsel Time: The highlight of every club night. We begin this portion of club with the pledges to the ags, followed with singing and a challenging lesson from the Bible. Godly men and women, missionaries, and pastors from our church bring the lesson by enthusiastically applying the truths of God’s Word to the lives of the boys and girls so that they will learn how to live a life that pleases God.
Handbook Time Handbook Time: King’s Kids Club listeners and leaders listen to boys and girls recite Bible verses that they have memorized out of their King’s Kids Club handbooks. All boys and girls will need to purchase a King’s Kids Club handbook that they will work through during the club year. These handbooks emphasize Scripture memory and a clear understanding of Bible truths. Awards are earned as sections in the handbooks are completed. These awards are displayed on a club banner or club hat as part of the King’s Kids Club uniform. Additional awards may be earned as a child completes one or more handbooks.
Special Events We have some special events planned for this year that are targeted to encourage children to work harder in their Scripture memorization, as well as have special activities to look forward to throughout the King’s Kids’ Club year.
Special events for this year include:
• Super Bowl - Nacho Night • Neon Night • Grand Prix • Christmas Store • Country Fair
There are also many other special surprises in store for King’s Kids Clubbers!
Objective
To create a graphic identity and corresponding print & multimedia materials that are modern, fun and child-friendly, keeping in mind the children targeted are around elementary school age.
Results
Projects created include an informational brochure, several posters and flyers for specific King’s Kids events and a website design.
web
2009 Show House Ad print Client | Decorator’s Show House & Gardens Planning Committee
Objective
To develop a eye-catching design for a piece that could be used as both an advertisement & flyer for Decorator’s Show House & Gardens.
Results
I researched the previous year’s publications in which the ad was placed, and came up with a layout that was a different style from the other ads in order to make this year’s layout stand out against the competition.
Sysco M.A. Recruitment Brochure The Posi t
Mar ion of the ketin Client | Sysco LLC: A Food Distribution Company AssoIndianapolis, g c INV Sysc iate OL o In VES Ou d iana
tsid Defi e Comm ne is Con d Territo sion Sale sulta r y Re s tive spon New Sell sibil A A Di ity Pene ccount D ing v evel MCarketrtiatng Larg ision Of oia pm oc redit ion OAf ss est F T te ent E x M T ood he Natio i s po he S ting ti an geitmh Sy Varisi serv n y A ed Won aw s sc c o Marketing Associate c c o e Corp ice Dis ’s t iate ounts Assnoc OnIn k Hol tiorng an godi tribu ar orat ouis M ike ng P apwith rs Sysco position i tor: o o n rodw h Sysc O ucit sition po Ope t An FF is an ouE Indianapolis tsi d de sales r a S R Sanapolis kills Tra Tem tes Fro posit di Caion focu m sed on p ining reeIn r In In erature A Mult deve Folop is an outside hofan rtunmeWntitsales iW d i a n e I saCles antsi n apol arehou 10sin les sa d bu de 0C position onou esoon sm ternatio is an is, In se Fa tinufocused in n a de p on d d g o a sig se O a cu na l i u fo ted n p a development of s Inc y nageneractinilgitand pion posit y developin rtuhic ome geogo In addition to rap nbusiness rketing S.eThi is to engage in itnt Esales ter me and ntve -Enh iesofritor s r ry, a Sysco Ma y. de con rito v ling relop sul ter sel i the tive in c sel pren business ling. This es anci sales in consul Credit age metoans eng h the no is t oninlyconsultive in amp designated engage selling. Thisers’ Acc In addition to rk generating and developing ng and euria tom Exsa closely wit meeting the Co ir add teles atesnwo ounAss to gen ociitio sat ir cus customers’ ion ly meetin rmation. eratincus nsien t on baased on curren er info g and tom anstno dev nee me tedisl M tses viss means not only meeting their customers’ sales in the a Sysco Marketing eloping naterritory. ds, bu e ion gather geographic sig sal ing t als torito nage comm also bec om a de A in entterritory, P Locin the tm om ter par c t r ing De bu o ry, r an ds, policies and aed Sys o knoren nee dit dudcrit spor al An hic ter cocre y. wletdg m ec Ma of s ial cur rke h eab inc current needs, but also becoming Associates work closely with the Credit rm s tin eac e le en Ass info ke eno tiv t Lin ocime nt Aes. ma areIrk ugh to D Traog aters ndcloiasely withcollectedg inirap s wo d Ninc ug maeke ng Custo eable eno h lude; cus p eA dieac tom atlud an int wledg Compensation is based on s are the information. er mo n customer Credit en knowledgeable enough to make each Department to gather BEN ge cainc iones re suc monie Depar vsiv ces s, and ailaeb proach kno initial progra ure t ent cessful.DThi cedtm Thiss can e a on to gather a suc pro can re sed l d inc mo ba cus m pro er is R lud as po eveista Te;o T singmore we ilies. eclloas er info commission and special custom ECo customer successful. This can include; Customers are informed oftom credit policies and new me ensation rmatio ty onen Cureq gotiv Fmp n. ing lonce gincentives. rs are informed tra uired. h nu ideas, ass ini assista IT inc n menu as stome ng ial p e thr nce new ec i g in ou sp t sin of m sol d gh S G po cre i vin an ou dit on pro g pro Training ant the intensive ion policies and proposing new assistance procedures, and monies are collected Med co row and ent issincludes blemenu pro ng ms ideas,chi mm cedures, and Ma ng and rketing Assoes i moniesMa blems,, researchi t ensive O Associate c pro int g h g sha tin an a are vin rin f rke sol col g n, cia l in ind lec A lud , co I tes atio solving problems, researching and as required. ust ted initial program as well as ongoing Insu Traini t’sThe ry and caree req t inform onnof da Sys ed. pouir Em ntinc ra c Deng track ustry and market informatio ll as onr.going ind encrin agra n, d oug l, Am psiti rag sha ing sharing industry and market information, loyeindividual with a proven thr ion in foo custom ndasVwethe Shor ntraining Apar inietial prothroughout ticipat ive pation in food dvtici requires an customer eacisatySysco ing shows i tiothe ability to ourag a s t ou and the enc gh ing encouraging customer participation in food n The position of Marketing Associate fac and a ou vid ility Marketing Associates career. thr pro c n tou n a r. positi tenof a Sys and proe Cove tra foron d iniong ming record Ors,pp vid ry facility tou cowith sam indgust Ma re ent eproven rke pleand ws sur ntin tes caCree tin s and sho rage Lrke res cia shows and facility tours, and providing requires an individual a track Ass h-p so g pro n. oci hig As req o du d, ate atio g uir ct rm ace T es info r erm tun.ni atio Ma in a fast-pan individual withers product 401( tural e cul ples and a pro div ability sam Disa ven m the ties samples and product information. record for and to thrive track record K) ple fro peoaci forh tenacity ten bilit filled wit A ty and the job The Pro v s. spe al nd abi Pres , Pensio a egr ctin ou lity int y g for new aa fast-paced, high-pressure industry to thr ilabl in backgr ers is an ion fas cat t-p n An cript ace edu d,alhigh-pressurtential and ive for new customers is an intyegral eand partspe of ctin po e ind the gjob Pro d io ustry Prospecting for. The newho customers is anma integral filled people from cultural omediverse inc Life filled with ited vary and wit unhlim peo ple from divem offers And n Drug P Stock Pu job. The hours vary and ma includ y rk as the erseent t of e iev par som cul wo ach part of the job. The hours vary and may and educational backgrounds. The job tur e nd eve for al y eke nin nital Ad we rcha edu la rtuion pocat Tuiti the op backgrounds. e evening and weekend wo. rk as som territo se Pl luderies inc on A &D Insu n Theand arema include some evening and weekend work as offers unlimited ped job offers nag ion.income potential nitited un og an lim rec develo naged and dev ssist and ranc elo inc ma ped om are Paid e . ries po tential and territo territories aremanaged and developed. the opportunity achievement an e opportunity for Vaca for achievement tion ce and recognition. recognit s
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Objective
The majority of Sysco Indianapolis’ print pieces are ugly, outdated or a combination of the two. This piece was no exception. The goal was to update this piece to be engaging and colorful to pique the interest of potential candidates for Sysco’s Marketing Associate program.
Results
I used dynamic, contrasting graphics with a decidedly corporate feel in order to give the piece, and the company, a sense of credibility and professionalism.
Mephibosheth Ministries Brochure print Client | Mephibosheth Ministries: A church-based program that works with the physically and mentally disabled
About Mephibosheth Ministries
How You Can Help
Mephibosheth Ministries, Inc. began with Friends Unlimited, an outreach disability ministry of Cicero Christian Church. It was through experience as an instructional assistant in the Moderate Mental Disabilities classroom that Becky Moore realized the church, along with 85-90% of all churches did not have a program developed to meet the needs of people with developmental disabilities. The ministry’s focus was to develop a spiritual fellowship group that would serve individuals who have various disabilities and their families.
Become a monthly donor! You may donate on the following levels:
In August of 1995, a ministry plan was presented to the leadership of Cicero Christian Church for a Tuesday evening outreach ministry designed to fulfill spiritual and emotional needs of the children. Friends Unlimited began in January, 1996 with three participants. The group quickly grew to twelve within the month, and hasn’t stopped growing yet! The roster now consists of over one hundred individuals of all ages and abilities with a record number of 135 participants and volunteers in attendance last winter! Friends Unlimited has been blessed with a wonderful staff of volunteers that enable us to have a one-to-one or two-to-one ratio.
Programs and Services: • Friends Unlimited: A Bible fellowship group which meets weekly on Tuesday evening • Adult Day Program: A daytime adult recreation/leisure program which meets during the week. Activities include socialization, learning daily life skills, games, crafts, gardening, exercise and volunteer activities. • Camp Mephibosheth: Partnering with Rainbow Christian Camp, we hold an overnight camp and 2 sessions of day camp.
GOLD donor $100 and above
SILVER donor $50
The Need BRONZE donor $25 and under
You may also give a one-time gift in any amount you choose. We are a faith based, 501(c)(3) organization. Your donation is tax-deductible. Please contact the Mephibosheth Ministries staff to become a donor. (Contact information for Mephibosheth Ministries is located on the back of this brochure.)
We have discovered a tremendous need for daytime activities for individuals with disabilities after they complete high school. Waiting lists are long, funds are short, and programs are few. Many individuals are sitting at home with little outside activity. We feel it is time for the community to step up to meet this need rather than rely on government resources. • Over 15,500 people throughout Indiana are on waiting lists for Medicaid Waivers that provide home and community based supports. Medicaid Waivers allow Medicaid to fund services to those who would otherwise qualify for care in a Medicaid funded institution1. • Many people on the Medicaid Waiver waiting lists have been waiting for as long as eight years1. The final state budget for the 2006-2007 biennium contains no new funding to move people off of waiting lists for Medicaid Waivers. While demand for quality day program services is high, new funds from state and federal funding are not available to meet this demand. These funding cuts create a high demand for day program services for people with developmental disabilities. The Arc of Indiana, Summer 2005.
1
Objective
Develop a piece targeting “Gold-Level” donors that accurately portrays the values and mission of the organization in order to encourage potential donors to give towards to Mephibosheth Ministries.
Results
This trifold brochure is colorful and upbeat, and gives information about the organization and donations. This was a pro-bono project produced by Outside Source Design; all labor and materials were provided free of charge. Other colleagues created a comprehensive DVD, attached inside of the brochure, that outlined the organization and it’s needs more potently.
Lilly Medicaid Helpline Brochure print Client | Eli Lilly & Company
Lilly Neuroscience
Medicaid Helpline 1-800-351-6902
Lilly Neuroscience Medicaid Helpline 1-800-351-6902
MG38067 1105 PRINTED IN USA Copyright © 2005 Eli Lilly and Company All Rights Reserved
Objective
Develop a clean, modern brochure that provides information about the Lilly Medicaid Helpline and how to access it. This brochure was meant to be given by doctors or nurses to patients that may be interested in using this service.
Results
I created a piece that was upbeat and informational, keeping the modern “pharma” look that Eli Lilly clients tend to like. I used more of the secondary branding colors, in order to get this piece to stand out from the other mostly red & white schemed pieces typical of Eli Lilly.
Byetta Time Trials Logo & Materials multi Client | Eli Lilly and Company - Byetta Team
The Time is
I
I
I
I I
I
I I
to pull AHEAD
We are in the final stretch of the BYETTA TIME Trials contest.
I
TIME
to grow BYETTA NRx’s
BYETTA TIME
Trials is a special incentive
program designed to reward you for increasing
BYETTA delivers:
Self-regulating glycemic control
your customers’ BYETTA trial rate by:
1
Increasing their understanding of the BYETTA value proposition
2
Building their preference for BYETTA by increasing trial rate and NRx’s
FOR INTERNAL USE ONLY EX-42182 ©2006, ELI LILLY AND COMPANY. ALL RIGHTS RESERVED.
I
I
TIME Trials race is in full swing!
I I
The RACE is on.
The BYETTA
I
I
TEAM BYETTA.
I
I I
The
TIME IS NOW
To succeed, you must increase trial rate among your targeted customers.
Objective
To create a fun, properly-branded logo for an incentive contest for Byetta Sales Representatives to be used on various materials.
Results
After a few different revisions, this composition was chosen for the final logo. It was the simplest of the options offered, used the Byetta brand colors to their full potential, and was easily incorporated into the Time Trials promotional materials.
American Legacy Ride Logo multi Client | The American Legion National Headquarters
Objective
To develop a vector logo for the American Legion’s annual American Legacy Ride. This yearly motorcycle ride across part of the United States raises money for college education funds for children of deceased veterans.
Results
I created a logo with a decidedly masculine feel, with some inspiration from tribal tattoo design. The logo has been applied to ALR’s blog, signs, and a myriad of printed materials.
BremnerDuke Sales Aids print Client | BremnerDuke: A Healthcare Facility Builder
Planning Helping you see tomorrow’s healthcare outcomes today. We start by working closely with the hospital to identify
there is an opportunity for operational improvement or
the strategic plan from an operational, market and facility
efficiency. Following this analysis, the programming of the
perspective. In essence, we identify your market position,
space establishes the form the facility needs to have in
what services you want to provide, how you would like to
order to effectively support the efficient flow of patient
provide them, and where you wish to locate the new
care and work.
facility. Then, the Bremner-Duke team works closely with your physicians to create proper physician alignment.
A critical factor in the overall planning process is the inclusion of key stakeholders. Bremner-Duke works with
We also look at operational and space programming
key hospital personnel and physicians throughout the
criteria. This consists of reviewing current operations and
planning process.
defining the form supporting the functions of your operation. The "function" includes identification of how patient care and work processes are to be performed. Functional identification is then analyzed to determine if
As you look to envision the possibilities of tomorrow's healthcare, look to the process and the expertise found in the Bremner-Duke team.
The keys to planning 1. Detailed feasibility study 2. Physician alignment strategies 3. Operational & space programming 4. Inclusion of all stakeholders
www.bremnerhealthcare.com 510 East 96th Street, Suite 250 Indianapolis, IN 46240 ph: 317-816-8600 fx: 317-816-8610
Specialty Care Hospitals Helping you build something special. As medical advances continue, areas of specialty grow as well. Increasing demands for dedicated space and building requirements often lead to innovative solutions serving both physician groups and their patients. One solution is the creation of a specialty hospital focusing on a particular area of care. For example, specialty care hospitals have been created for women’s health, orthopedics, wellness, cardiology, oncology and much more. The requirements are unique and the project demands high. That’s why you need a company with a medical pedigree – a specialization. At Bremner-Duke, we offer a complete scope of planning, development, ownership and management services. In addition, our recent joint venture with Duke Realty offers customers market insight, available capital and flexible
construction models. The end result is comprehensive medical experience in combination with the capital strength and financial stability of a development leader. Bremner-Duke brings this unique perspective to specialty care hospitals. In addition to over 20 years of experience and close to $1 billion in healthcare projects, we bring asset and facility management services to hospitals after they open. Our in-depth understanding of compliance issues, maintenance, physician and clinician needs as well as market dynamics ensures a high quality and cost-effective facility. In the end, this is more than a building. This is a facility where patients receive the special care they need. Let Bremner-Duke help you build something special.
The keys to Specialty Care Hospital Projects 1. Proven Specialty Care Hospital experience 2. Feasibility and project analysis 3. Flexible ownership models 4. Physician joint venture experience
www.bremnerhealthcare.com 510 East 96th Street, Suite 250 Indianapolis, IN 46240 ph: 317-816-8600 fx: 317-816-8610
Objective
To create high-end sales aid and sells sheets for BremnerDuke Sales Representatives to use with potential clients.
Results
The booklet covers features a subtle metallic spot color to immediately portray a feeling of class and professionalism. The overall aesthetic of both the multi-page booklets and the single-page sheets was kept clean and structured as an homage to modern architecture.
Eli Lilly Reintegration Awards print Client | Eli Lilly and Company
Objective
To develop an invitation and mailer for the yearly Lilly Reintegration Awards program.
Results
I created a one-color logo variation from the pre-existing multi-color logo, and designed the invitation and mailer according to branding guidelines. The logo variation was applied to the invitation and other event promotional materials.
Carrier & Bryant Dealer Boxes pkg Client | Carrier-Bryant
Objective
Create a box for Carrier & Bryant Dealers to store a variety of sales materials they receive throughout the year.
Results
This project involved sourcing an appropriate custom box printing company and working with them on specs for a box design for this project (and creating many, many, many mock-ups). For both boxes, I pulled imagery from branding libraries and wrapped the box in those graphics, making the box visually interesting from all angles.
Avant Sell Sheet print Client | Avant Healthcare
Promotional PROGRAMS Avant Healthcare Marketing, a division of Deborah Wood Associates, offers promotional programs at the core of its marketing solutions portfolio. Working with you, the Avant team designs a comprehensive strategy based on your needs and the lifecycle of your product. Once a strategy is determined, every aspect, from planning to execution, is developed by seasoned experts in direct-to-healthcare professional marketing strategies.
Thinking Forward
Avant can make your programs stand out from the rest with creative solutions to help you realize your product’s full marketing potential.
Create a Marketing Partnership
Promotional Program Timeline
The Avant Healthcare Marketing team analyzes a client’s marketing objectives and identifies creative strategies that
Scientific Content Development
STRATEGY Marketing Objectives Analysis
Slide Kit Development
Partnering With Sales Force
ROI and Outcomes Measurement
Meeting Planning and Program Implementation
Develop Scientific Content MEASUREMENT
EXECUTION Multilayered Recruitment Strategy
will appropriately reach a specific healthcare market. Determine Need for Future Programs
Program Analytics
95% found the program content relevant to their practice
Medical Affairs Department can transform raw data into content rich presentations that can impact attendees and strategically align with your desired goals.
Generate Audiences We use a variety of recruitment methods based on 32 years of combined experience in audience generation to improve
)
Avant promotional programs can impact physicians’ behaviors and patient management skills.
Using their strong scientific/medical backgrounds, our
Participant and Faculty Communications
Program Formats That Stand Out
))
Measure the Impact
response rates to your programs. Our in-house multimedia
Dinner Series:
Targeted programs in convenient local locations
Satellite Series:
Live programs broadcast from a central location
Web Casts:
Visually appealing programs with live interaction, polling questions, and real-time Q&A
Audioconferences:
Live interaction with polling questions and real-time Q&A
department and recruitment team work together to produce high-quality materials to help you achieve attendance goals.
Strategic. Intelligent. Experienced.
92%
felt they had the appropriate resources to help coach their patients to be compliant, based on the information presented
91%
stated that appropriate resources were provided to manage patient side effects
Based on 2005 promotional dinner series managed by Avant
Visual, creative, and innovative, we produce everything in-house from slide kits to advertisements to meet all of your program needs. For more information on how Avant can improve your direct-to-healthcare professional marketing communications, contact us at 317.208.3600 or at www.avanthealthcaremarketing.com. Avant Healthcare Marketing is committed to enforcing the highest ethical standards and strictly follows all FDA, AMA, PhRMA, OIG, and other regulatory guidelines.
Strategic. Intelligent. Experienced.
Objective
Develop a modern style for a sells sheet to be used by pharmaceutical representatives of Avant Healthcare.
Results
This company had no branding guidelines, so I used a consistent, bright color scheme for this piece. I created custom icons and created charts from the text-only information given. The feel of the piece was kept upbeat and young.
Sysco Facility Visit Materials print
multi
Client | Sysco Indianapolis, LLC: A Food Distribution Company
Objective
To develop individual screen graphics informational booklets tailored to the needs of Sysco customers coming to the building for facility visits, business reviews and samplings.
Results
Each booklet features a custom design based on the visiting company’s current logo or branding scheme, the visitor’s company name, key Sysco contact names, a list of food items being presented and any additional information requested by the visitors or their sales representative.
Xigris Graphic Panels print Client | Eli Lilly and Company - Xigris Team
Clini Cal i n d i C at o r s t o a s s e s s d is e a s e s ever it y f o r s e v e r e s e p s i s pat i e n ts
Xigris survival Benefit is Consistent aCross high-risk severe sepsis patients prowess1
identifying the progression of severe sepsis
Xpress*
• Randomized, double-blind, placebo-controlled trial of 1690 patients with severe sepsis Oxygenation
BP
INFECTION
SEPSIS
SUPPORTIVE CARE »
Fluids
BP
(RR>30) (PaO 2 < 55 mm Hg)
MODS
SEVERE SEPSIS
Supplemental O2
• Objective was to investigate the effect of Xigris on 28-day all-cause mortality
O x y g e n a ti o n
(M AP b 70 mm Hg)
DEATH
SYMPTOMS »
Vasopressors
• Randomized, double-blind, placebo-controlled trial of 1935 patients with high-risk severe sepsis (eg, APACHE II ≥25 and/or ≥2 organ dysfunctions) all receiving Xigris • Objective was to investigate the outcome and safety profile of prophylactic heparin when concomitantly administered with Xigris
28-D ay Morta L ity
28-D ay Morta L ity
sta ND arD therapy ( apa Che ii † ≥25)
Xigris ( apa Che ii ≥25)
Xigris + prophy L aC ti C hepari N
X igris + p LaCebo
43.7%
30.9%
28.3%
31.9%
Mechanical Ventilation
sU r Vi Va L
sU r Vi Va L 100
100
HIGH RISK
90
90
Cultures • Antibiotics • Source Control
80
80
70
70
60
60
Cardiovascular Dysfunction (Mortality by Vasopressor Use)1 60% 50%
Mortality by Number of organ Dysfunctions2
40
58%
P<0.0001
70% 60%
76%
65%
xigris + Heparin (n=976) xigris + standard Therapy (n=959)
40 0
28 Days
28 Days
P=0.0002
P=0.0858
Xigris benefit is Consistent
50%
37%
30%
xigris (n=414 at randomization) standard Therapy (n=403 at randomization)
0
80%
CMH Trend Test
40%
50
50
40%
20%
44%
30%
10%
20%
0%
N =294
N =4 1
No Vasopressor to No Vasopressor
No Vasopressor to Low-Dose* Vasopressor
20%
N=36 No Vasopressor to high-Dose* Vasopressor
respiratory Dysfunction (Mortality by Change in soFa† score)2
FaVo rs X i g ri s
21%
10%
FaVo rs pL a Ceb o
apaChe ii† ≥252
28-Day Morta Lity
t o ta L (N )
(95% CoNFiDeNCe iNterVaL)
Xigr is %
817
0.70 (0.59–0.85)
30.9
reLatiVe risk
p La Ceb o %
43.7
FoUr
0% o Ne
two
FoUr
three
renal Dysfunction (Mortality by serum Creatinine Levels)1
ORGAN DYSFUNCTION ≥2
1271
0.78 (0.66–0.93)
26.5
33.9
CAP‡ WITH APACHE II ≥254
321
0.60 (0.44–0.82)
26.2
43.5
3
CAP‡ S. PNEUMONIAE WITH APACHE II ≥255§
92
0.40 (0.20–0.78)
18.0
45.2
INTRA-ABDOMINAL SURGERY WITH APACHE II ≥252§
116
0.60 (0.36–1.00)
26.8
45.0
454
0.71 (0.55–0.91)
30.5
43.0
OVERT DIC6§
29%
relative reduction in risk of death with Xigris||
0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6
60% 50%
70% CMH Trend Test
57%
P=0.0004
0%
P<0.0001
61%
data is from proWess clinical trial.
40%
30%
10%
CMH Trend Test
50%
40%
20%
60%
reL at i Ve ri sk o F D eat h (95% C i )
30%
27% N=355 iMproVeD by Day 1
30%
The 95% relative risk confidence interval for each subgroup included the point estimate for the overall proWess population (0.80). The point estimate of relative risk of death in each subgroup is indicated by a solid circle, and the 95% confidence interval is indicated by the horizontal lines. note the consistency between the overall trial results and the subgroup analyses.
35%
20%
N =398
N=94
UNChaNgeD at Day 1
worseNeD by Day1
* B ased on the Sequential Organ Failure Assessment (SOFA) score, low dose was defined as dopamine 6-15 mcg/kg/min, epinephrine (less than or equal to sign) 0.1 mcg/kg/min, or norepinephrine (less than or equal to sign) 0.1 mcg/kg/min. High dose was defined as dopamine > 15 mcg/kg/min, epinephrine > 0.1 mcg/kg/min, or norepinephrine > 0.1 mcg/kg/min. † Sequential Organ Failure Assessment (SOFA).
10%
19%
0%
N=129
N=109
N=38
1.2 to 1.9 mg/dL to < 1.2 mg/dL
1.2 to 1.9 mg/dL to 1.2 to 1.9 mg/dL
1.2 to 1.9 mg/dL to > 1.9 mg/dL
1. L evy MM, Macias WL, Vincent J-L, et al. Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med. 2005; 33:2194-2201. 2. A ngus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001; 29(7):1303-1310.)
* Xigris and prophylactic heparin in severe sepsis † APACHE (Acute Physiology And Chronic Health Evaluation). For more information on using the APACHE II scoring system, please see http://www.sfar.org/scores2/scores2.html. ‡ Community-acquired pneumonia. § Nonprospectively defined population. || Relative risk reduction at 28 days. ¶ Therapeutic-dose heparin was not studied. 1. Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001; 344(10):699-709.
2. Barie P, Williams MD, McCollam JS, et al. Benefit/risk profile of drotrecogin alfa (activated) in surgical patients with severe sepsis. Am J Surg. 2004; 188(3):212-220. 3. Dhainaut JF, Laterre PF, Jones JM, et al. Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial. Intensive Care Med. 2003; 29(6):894-903. 4. Laterre, PF, Garber G, Levy H, et al. Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS study. Crit Care Med. 2005; 33(5):952-961. 5. Data on file, Eli Lilly and Company: XIG20060922b. 6. Dhainaut JF, Yan SB, Joyce DE, et al. Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation. J Thromb Haemost. 2004; 2(11):1924-1933.
Bleeding is the most common adverse reaction associated with Xigris therapy. please see important safety information.
Objective
To utilize the drug’s new branding in large format graphics for a medical symposium.
Results
The main challenge of the project was to create eye-catching, easy-to-read graphic charts for the provided data.
VMS Welcome to Indy Brochure print Client | Virtual Marketing Strategies
Objective
Regulations on what gifts could be given to pharma/medical employees have tightened. This piece developed in response to a need to have a gift that would be considered â&#x20AC;&#x153;no-costâ&#x20AC;?, yet still provided some value and interest to the recipients. The recipients were pharmaceutical representatives that were new to the Indianapolis area.
Results
After a discussion with colleagues to determine what could be created that would be acceptable, we had a brainstorming session and decided to develop a welcome brochure that would highlight new and notable locations in Indianapolis to visit.
The END