Parkinson's Disease Foundation Annual Report 2011: The PDF Effect

PARKINSON'S DISEASE FOUNDATION

Annual Report 2011

THE

PDF EFFECT

The mission of the Parkinson's Disease FoundationÂŽ (PDFÂŽ ) is two-fold: to understand and find the cure to Parkinson's disease and related movement disorders; and, for as long as this search continues, to ensure that those individuals and families who live with Parkinson's are able to achieve and maintain the best possible quality of life.

Cover and inside cover Members of the Parkinson's Support Group of the Mid-Hudson Valley gather at their third annual Parkinson’s Awareness Month walk in Poughkeepsie, NY, which benefited PDF.

Table of Contents 2

Letter from Leadership

4

Energizing Science

8

Empowering People

14

Improving Care

16

Our Donors

32

Our Researchers

34

Financial Reports

36

Our People

The theme of our Annual Report this year is “The PDF Effect.” What does this line mean? To us at the Parkinson’s Disease Foundation (PDF), it means focusing not just on what we put into our work, but what comes out of it. Not just the shape and direction of the programs we design — and with your help, execute — but the impact of those programs on the pace of science, and on the lives and futures of the people we serve.

Take, for example, the research programs we fund (see the section Energizing Science). We have highlighted just four research grant recipients (selected from among the dozens we funded in 2011) to illustrate what we do in this area: a young student Fellow from Germany; a senior scientist at Memorial Sloan-Kettering Cancer Center (MSKCC); a team of scientists at the University of British Columbia; and a clinical researcher at the PDF Research Center at Rush University. They were selected through our rigorous peer-review process because of their superior track records in the past and high potential for creative contributions in the future.

But what exactly are they accomplishing with the money we give them?

Well, the student Fellow is working on finding

2 | Letter from Leadership

new “targets” for Parkinson’s treatments in a lab at Massachusetts General Hospital. The MSKCC scientist is studying the role of stem cells in potential Parkinson’s treatments. The Canadian team is studying a specific gene mutation that — though rare — may help illuminate a whole area of neurodegenerative disease. And the Rush University scientist has found a possible “marker” for Parkinson’s in the colon of people with the disease.

These people and others like them, make up an A-team of scientific explorers, working at the edge of the known universe of neuroscience. And they are getting things done — things that will answer questions, solve problems and improve lives.

Then there are the ways we work with people who live with Parkinson’s and their loved ones (see the section Empowering People). Here, “The PDF Effect” is of two main kinds. One is to provide the information that people can use to improve their own lives as “managers” of their Parkinson’s — for example, our national HelpLine, our portfolio of publications and our popular PD ExpertBriefings online seminar series.

The other is to provide programs that can em-

Letter from Leadership

power people with leadership potential to serve as advocates for the development of new research and treatments. Through our Parkinson’s Advocates in Research program, lay advocates are trained through three-day institutes and more recently, through online courses, to play leading roles in advancing research. The work that these people do helps themselves, and it helps their communities. It is all part of “The PDF Effect.”

A third area that carries the stamp of “The PDF Effect” is the quality of care that is provided to people with Parkinson’s (see the section Improving Care). Take for example our innovative online Parkinson’s course for physical therapists — designed by a blue-ribbon committee of leaders in that profession, and modeled on a course in Parkinson’s for nurses that we developed a year earlier. Or take the network of training initiatives we provide for future leaders of the movement disorders profession, in PDF-funded medical centers like Columbia and Rush Universities, and through professional organizations like the Parkinson Study Group and the American Academy of Neurology.

Of course “The PDF Effect” would not exist without Our Donors — 41,000 of them in 2011 alone. In this report, we list the names of more than 1,600 donors who made gifts of $500 or more between July 1, 2010 and December 31, 2011 to support the research and other activities of the Parkinson’s Disease Foundation. We thank them for all they have done to make our work possible, and

we recognize the proceeds of their generosity in the section Financial Reports. From these and all our other sources of revenue, PDF received a total of $10,284,389 during the fiscal year that ended June 30, 2011 — an increase of $757,979, or more than seven percent, over the amount we received during the same period in 2010.

Nor would “The PDF Effect” exist without the people who make it all happen, from day to day.

These include a devoted Board of Directors and People with Parkinson’s Advisory Council; an outstanding network of scientists and educators who volunteer their services to PDF; and a creative and industrious professional staff of 24. They are the people who make “The PDF Effect” possible. We thank them, one and all.

Sincerely yours,

Robin Anthony Elliott Executive Director

Lewis P. Rowland, M.D. President, Board of Directors

The PDF Effect: Annual Report 2011 | 3

Since its founding in 1957, the Parkinson’s Disease Foundation has supported hundreds of research projects throughout the world — furthering Parkinson’s science and improving the lives of individuals touched by the disease. PDF's funding philosophy is to empower stakeholders — Parkinson’s scientists, clinicians and other members of the scientific community — to identify novel questions about, and answers to, the puzzle of Parkinson’s. The research program is guided by PDF’s Scientific Advisory Board, joined by representatives of PDF's Parkinson’s Advocates in Research program.

Identifying New Targets for Parkinson’s Treatments

α-synuclein levels

an advanced imaging technique that provides a Excessive amounts of the protein alpha-synu“window” on a living mouse’s brain, Mr. Ebrahimiclein in neurons can predispose a person to Fakhari and coworkers showed that both pathways Parkinson’s disease (PD). Now a study in the Octorecycle alpha-synuclein. UPS is the main recycling ber 12, 2011 issue of The Journal of Neuroscience pathway for alpha-synuclein under norhas identified two distinct cellular pathmal conditions, whereas ALP kicks in ways that help neurons dispose of un300% only when levels of alpha-synuclein are wanted alpha-synuclein. high, as in the neurons of some people Previous studies on the roles of the with Parkinson’s. Enhancing the work of two recycling mechanisms, the ubiqui200% UPS or making the ALS mechanism kick tin-proteasome system (UPS) and the in sooner (before too much alpha-synuautophagy-lysosome pathway (ALP), in 100% clein accumulates) should be studied to alpha-synuclein degradation have produced conflicting results. To settle this slow down or even prevent Parkinson’s. debate, Darius Ebrahimi-Fakhari, a medThese findings may help scientists 0 No Inhibitor Inhibitor ical student at the University of Heidelunderstand what causes Parkinson’s berg in Germany, undertook a PDF(e.g., how the recycling mechanisms are This graph illustrates the accumulation of alphafunded summer student fellowship in faulty) and help scientists identify new synuclein in the presence of inhibitors of the cell's targets for Parkinson’s treatments. the lab of Pamela McLean, Ph.D., at two recycling pathways.

Massachusetts General Hospital. Using

4 | Energizing Science

Energizing Science

Clarifying the Role of Stem Cells in Parkinson's Treatments Scientists, funded in part by PDF, announced in the November 2011 issue of Nature, that they have transformed pluripotent stem cells into dopamine neurons and implanted them into the brains of animals.

Pluripotent stem cells, such as those derived from embryos and more recently induced from adult skin cells, have the potential to develop into nearly any cell type, but scientists have had trouble transforming these stem cells into the desired cell type.

For the first time, Lorenz Studer, M.D., at the Memorial Sloan-Kettering Cancer Center and his colleagues appear to have identified the correct conditions necessary to transform pluripotent stem cells exclusively into dopamine neurons that resemble those lost from the same brain region affected by Parkinson’s, that grow and perform well in animals, and do not produce tumors. The fact that these transplanted neurons reduced some Parkinson’s symptoms in animals is a good sign for potential therapeutic applications in people living with PD.

Before stem cell therapy for Parkinson’s becomes a reality, however, significant challenges remain. Longer-term experiments in monkeys must be done to show that the neurons can survive and avoid tumor formation for longer than one month and can alleviate PD symptoms. Animals in these experiments were also given immune-suppressing drugs to prevent their bodies from rejecting the transplanted cells. These drugs have substantial side effects when taken long-term, which must be balanced against the benefit of improved PD symptoms. Furthermore, stem cells may replace the cells that are affected by Parkinson’s, but they will probably not stop the neurodegenerative process.

Nevertheless, until a safe and effective stem cell replacement therapy has been demonstrated, this new protocol can been used in the laboratory to efficiently generate large quantities of the dopamine neurons necessary to screen and test potential drug therapies currently under investigation.

Newly made dopamine-producing neurons derived from stem cells

“The fact that these transplanted neurons reduced some Parkinson’s symptoms in animals is a good sign for potential therapeutic applications in people living with PD. ” The PDF Effect: Annual Report 2011 | 5

Energizing Science

Discovering a New Genetic Mutation Linked to Parkinson's developed Parkinson’s and others did not.

In the past, this type of DNA analysis has been very difficult, requiring examination and DNA collection from large numbers of affected families.

The University of British Columbia researchers instead used a new and efficient technique called whole exome sequencing, which focuses on small, but important, sentence-like sections of DNA. These sections govern the production of proteins.

Since mutated proteins are most often the cause of genetic diseases, they reasoned that mutations linked to inherited PD would be found here.

Like most other genetic causes of PD, this newly identified genetic mutation is exceedingly rare, resulting in very few cases of PD. Nevertheless, a better understanding of how a VPS35 mutation causes cellular processes to go awry may help scientists to unravel the causes of PD and other neurodegenerative diseases.

Using a new, cutting-edge technology for gene sequencing, researchers funded in part by PDF have discovered a new gene called vesicular sorting protein complex 35 (VPS35) that is linked to Parkinson’s in people with familial PD. The results appeared in the July 15, 2011 issue of the American Journal of Human Genetics.

In recent years, researchers have identified about a dozen genes that either cause Parkinson's or increase the risk of developing the disease. To search for a new PD gene, an international team of researchers led by Carles Vilariño-Güell, Ph.D., and Matthew J. Farrer, Ph.D., of the University of British Columbia, Vancouver, Canada, focused on a family from Switzerland in which 11 people in three generations were diagnosed with PD. They compared the DNA of family members with PD to that of unaffected family members to search for differences that could explain why some members

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A pedigree of the original Swiss family used to identify the VPS35 mutation. Filled symbols indicate individuals affected with PD and the number below the symbol indicates their corresponding age at disease onset. Individuals are either mutation carriers (M) or have a normal (wt) genome. Square symbols are male and round symbols are females. Diamond symbols are number of children, no sex specified. Slash marks indicate deceased individuals.

6 | The PDF Effect: Annual Report 2011

Finding a Biomarker for Parkinson's Disease Unlike other conditions that can be diagnosed through blood tests or biopsies, there is no definitive test or "biomarker" that can identify Parkinson's or trace its development. A study funded in part by PDF and published in the July 2011 issue of Movement Disorders suggests that the presence of the alpha-synuclein protein in the colon may be a biomarker for the disease.

leagues published additional results in the June 2012 issue of Movement Disorders suggesting that doctors may be able to diagnose early Parkinson's with a colonoscopy. In this study, Dr. Shannon detected alpha-synuclein in colon tissue samples removed two to five years before the individuals reported any symptoms of Parkinson’s (see image below). If the findings from this very small study are replicated in a

“Early detection of Parkinson's, before the significant loss of dopamine-producing neurons, would help facilitate a search for a cure, or for interventions that slow disease progression.

”

In people with PD, the alpha-synuclein protein forms abnormal clumps in cells, and these toxic aggregates kill dopamine-producing neurons. One hypothesis suggests that Parkinson's may actually begin in neurons of the intestinal wall and spread by cell-to-cell transfer of alpha-synuclein through the vagus nerve to the brain.

In support of this hypothesis, Kathleen Shannon, M.D., and her colleagues at the PDF Research Center at Rush University Medical Center detected alphasynuclein in colon tissue samples of people with early Parkinson's. This study is the first to demonstrate alpha-synuclein aggregation in colon tissue.

Building upon this work, Dr. Shannon and col-

larger number of samples, it may be possible to use colonoscopy to predict who may develop PD. Doctors already recommend that people age 50 and older have a colonoscopy every three to ten years for colon cancer surveillance. For those who would be interested, the same biopsy may be able to predict their risk for Parkinson’s. Therefore, it would be relatively easy to test colon tissue biopsies for both cancer and the alpha-synuclein protein.

Although these initial results are promising, it will be important to confirm the results in larger populations of people with and without PD, as well as in people with Parkinson's-like disorders.

Energizing Science | 7

Central to PDF’s philosophy is the belief that people with Parkinson’s must be key partners on initiatives that move the cause forward. To make this happen, PDF recognizes that the community needs certain tools to effectively make a difference. In recent years, PDF has made a commitment to providing these tools to empower people touched by Parkinson’s to become actively engaged in research, education and advocacy efforts in their communities.

Finding Ways to Speed New Treatments The current process that brings new Parkinson’s treatments to market is very slow. There are many factors that may contribute to this delay but PDF believes that in order to speed this process, people with Parkinson’s must be primary partners in research alongside scientists, government and industry. PDF's Parkinson’s Advocates in Research (PAIR) program offers intensive in-person trainings, known as Learning Institutes, and an online course to provide people touched by Parkinson’s with the scientific knowledge and leadership skills needed to advance research in their communities. Since its launch in 2008, the PAIR network has expanded to include more than 180 Research Advocates from 38 states. In 2011, PDF Research Advocates were involved in a wide range of leadership activities including the examples below.

Guiding Parkinson’s Research A PDF Research Advocate since 2009, Diane Cook was named in 2011 to the Board of Directors of the Colorado Neurological Institute (CNI) where she assists with the review of clinical trials. Ms. Cook is also co-investigator with Rajeev Kumar, M.D., of CNI, and Katen McRae, M.D., of the University of Denver, on a research study to determine the efficacy of a model training program she helped to create that is specifically geared toward people with Parkinson’s disease in a support group environment. The model involves incorporating skills of self-efficacy into the support group’s curriculum. Ms. Cook’s efforts have helped nearly 100 people with Parkinson’s get involved with research.

8 | Empowering People

Empowering People

Educating Their Community About Research Studies A PDF Research Advocate since 2010, Bernie Snead believes that one of the simplest ways to advance research is to let the community know what they can do to help. In collaboration with Parkinson Association of the Carolinas (PAC), Mr. Snead brought the latest information to support groups in North and South Carolina in 2011.

Interweaving the PDF guide, Getting Involved in Parkinson’s Research, with his own personal experiences in volunteering for trials, Mr. Snead presented to 13 support groups in six months and was selected to be a member of the PAC Speakers Bureau.

Following Mr. Snead’s presentations, the number of support group members who stated that they were likely to participate in a clinical trial increased by 50 percent.

Filling Gaps in Parkinson’s Research Another PDF Research Advocate from 2010, Ronnie Wanetick collaborates with major Parkinson’s research centers in Northern California to address a major barrier to Parkinson’s research: improving the system that informs people of clinical trials taking place within their community. Working with study coordinators at the University of California at San Francisco, The Parkinson’s Institute and the University of California at Davis, Ms. Wanetick receives a list of all enrolling studies and she then distributes this list to support groups in her area. In just over two months, 13 individuals have enrolled in studies because of this system, dramatically reducing the length of time that it has taken clinical trials at these centers to enroll.

2011 Learning Institute Graduates

“It will be invaluable to have knowledgeable PDF Research Advocates join our team of researchers, doctors and other professionals, in order to prioritize Parkinson’s disease research and improve studies. ” Jay Nutt, M.D.

Oregon Health & Science University (OHSU) Parkinson Center of Oregon and Movement Disorders Program

The PDF Effect: Annual Report 2011 | 9

Empowering People

Connecting the Parkinson’s Community to Resources A top priority for PDF remains the dissemination of accurate, accessible information about Parkinson’s to people with the disease and their families.

The cornerstone of our efforts is our national toll-free HelpLine, which is staffed by trained information specialists who can answer questions about Parkinson’s and connect people living with the disease to community resources. In 2011, more than 5,000 people from all over the country were advised through our HelpLine.

To address the financial concerns facing many people with Parkinson's, PDF once again awarded $50,000 in 2011 to the Melvin Weinstein Parkinson’s Foundation to help individuals who meet certain eligibility requirements pay for a home health aide or visiting nurse and purchase such medical equipment as wheelchairs, walkers and canes. Since 2008, the Helen M. Lynch Direct Aid Fund of the Parkinson’s Disease Foundation and the Melvin Weinstein Parkinson’s Foundation has helped over 500 people in the Parkinson’s community.

“Thank you for the very useful information you provide. Your publications are a staple in the educational materials that we provide to our newly diagnosed Parkinson’s patients.

”

Lisa H., R.N. Fayetteville, AR

10 | The PDF Effect: Annual Report 2011

PDF also offers a growing portfolio of educational materials that are developed in response to community needs. In 2011, over 800,000 print educational publications were distributed worldwide.

The Second Edition of our most popular and visible publication, the Parkinson’s Disease Resource List, was released in April 2011. The print and online version of this new edition includes over 750 resources for the Parkinson’s community throughout the US and around the world. The concept for this publication developed from conversations with our People with Parkinson’s Advisory Council.

In response to requests from the community, PDF added 10 fact sheets in 2011 to our line of educational materials. These fact sheets cover a range of topics from Fatigue and Sleep Disorders to Caring for the Care Partner. PDF now has over 50 fact sheets that offer in-depth information about specific areas of Parkinson’s treatment and care.

They are written by physicians and people living with Parkinson’s and many are available in Spanish.

Providing Access to Leaders in Parkinson’s Research and Care

“I have learned so much from your seminars. They have been clear and understandable for someone without a science background. They have made it much easier to face the diagnosis and put it in perspective.

”

LISTEN WATCH LEARN

Ann M.

Chicago, IL

Recognizing the ongoing need to provide people with Parkinson's and their families with research updates and strategies for living well with the disease, PDF continued in 2011 our popular PD ExpertBriefings online seminars. This program provided people with Parkinson's around the country, and the world, with first-hand access to the insights of some of those who are at the forefront of Parkinson's research and care. Topics covered in 2011 included: • Physical Therapy and PD — What You Need to Know, led by Heather Cianci, P.T., M.S., G.C.S., of the Dan Aaron Parkinson’s Rehabilitation Center (Good Shepherd/Penn Partners) at Pennsylvania Hospital in Philadelphia, PA • Cognition and PD: What You’ve Always Wanted to Know But Were Too Afraid to Ask, led by Alexander I. Tröster, Ph.D., of the University of North Carolina at Chapel Hill

• Understanding Pain in Parkinson's, led by Jeffrey Wertheimer, Ph.D., of Cedars-Sinai Medical Center in Los Angeles, CA • Impulsive and Compulsive Behaviors in Parkinson’s, led by Daniel Weintraub, M.D., of the University of Pennsylvania in Philadelphia, PA • Caring for a Person with Late Stage Parkinson’s, led by Joan Gardner, R.N., B.S.N. and Rose Wichmann, P.T., of the Struthers Parkinson's Center in Minneapolis, MN These seminars are available for viewing from the comfort of home, 24 hours a day, seven days a week. For those who may not have the technology to watch online, PDF offers DVDs of this series.

Since 2007, PDF has held more than 30 online seminars and in 2011, more than 10,000 individuals in 38 countries participated in at least one of our PD ExpertBriefings.

• What's in the PD Pipeline?, led by Michael Schlossmacher, M.D., of the University of Ottawa

Empowering People | 11

Empowering People

Making an Impact During Parkinson’s Awareness Month In 2011, PDF once again took the lead in helping the Parkinson’s community mark April as Parkinson’s Awareness Month. The theme of our 2011 campaign was “Shatter the Myths” about what it means to live with Parkinson’s by spreading the word, educating the community and supporting research for the cure. The theme resonated with many individuals across the country as captured in the inspiring highlights below.

Spreading the Word • 20 individuals, including Ruth Pearce in Gainesville, GA, displayed the Parkinson’s Quilt in 11 states. An estimated 2,500 people visited the quilt during April.

• Many individuals, including PDF Research Advocates Jim Patterson of Dunedin, FL, and Patti Meese of Scottsdale, AZ, successfully had proclamations signed by local, state, and federal officials. The United States Senate also proclaimed April as Parkinson’s Awareness Month.

Sample Chock full o’Nuts cup

• Chock full o’Nuts helped PDF’s efforts by featuring an awareness message on one million coffee cans, and an advertisement in a national Sunday circular and on cups and displays in stores in New York City.

Members of PDF’s People with Parkinson’s Advisory Council at the 2011 Parkinson’s Unity Walk

“It is amazing to experience what people can do to show support for those of us who are living with Parkinson’s disease. ” Jerry T.

Mount Vernon, NY

12 | The PDF Effect: Annual Report 2011

Educating the Community • More than 1,400 individuals wore one of the Parkinson’s Awareness Month t-shirts designed by winners of the annual design contest, Marian Bumala, of La Honda, CA, and Stephanie Longo, of Cherry Hill, NJ. • PDF Research Advocates John Baumann of Louisville, KY, and Linda Hinkle and Mary Yeaman of Indianapolis, IN, partnered with the Indiana Pacers to host an event that included a Rock Steady boxing demonstration, educational handouts and a reading of a proclamation during half-time.

PDF Research Advocate Carolyn Weaver of Freeland, MI, brought posters and informational materials to 13 different locations in her state.

Marian Bumala holding an image of her winning t-shirt design

• Libraries proved to be a great spot for education. PDF Research Advocate Gordie Guist, of Camden, ME, was one of 42 individuals who set up an educational display about Parkinson’s.

Supporting the Cure • More than 750 individuals helped PDF to raise $200,000, (well over the initial $100,000 goal) for the Irving G. Brilliant Parkinson’s Research Challenge. Because the challenge met its goal, Mr. Brilliant also increased his matching gift to $200,000, which meant that a total of $400,000 was raised for Parkinson’s research.

• PDF Champions held unique fundraising events across the country raising $38,000. In Ocala, FL, Barbara Hebert brought the first Parkinson’s walk to her community and raised nearly $3,000.

Barbara Hebert and friends at the first Parkinson’s Walk in Ocala, FL

• Gristedes Supermarkets partnered with PDF in the New York area and raised over $5,000 through the campaign, “Tulips Bloom for Parkinson’s.”

Empowering People | 13

A core component of our mission is ensuring that people with Parkinson’s and their families have the best quality of life. This is only possible when people living with Parkinson’s receive the best possible care. For over 35 years, PDF has offered mentorship programs that provide the training needed to ensure that the best minds are recruited to Parkinson’s research and care. In recent years, PDF has expanded its training programs to include online courses for healthcare professionals serving people with Parkinson’s.

Investing in the Training of Physicians and Researchers Although the number of people living with Parkinson’s is expected to increase in coming years, there is a shortage of the physician-scientists necessary to help not only understand Parkinson’s, but also to carry new discoveries forward into the clinic to help people living with the disease. So how can the best physicians be encouraged to acquire additional training in Parkinson’s disease? PDF focuses on this challenge and invests in the training of physicians and researchers throughout their careers.

One of these physician-scientists is Christopher W. Hess, M.D., a Research Fellow at Columbia University Medical Center. During the first two years of his fellowship, Dr. Hess honed his skills in the care of people with Parkinson’s and became interested in researching how the nervous system affects movement in Parkinson’s.

14 | Improving Care

Dr. Hess’s research involves investigating the brain’s ability to “compensate” in Parkinson’s. It turns out that the brain — its cells and the billions of connections between them — shows a limited ability to change and adapt when faced with new experiences, including injury and illness.

For example, in Parkinson’s, the area of the brain known as the basal ganglia — which helps to produce the body’s voluntary movements — stops working when it loses dopamine producing cells.

When this happens, Dr. Hess speculates that other parts of the brain may lend a helping hand.

This means that although the basal ganglia are not working properly, other parts of the brain kick in to ensure that a person with PD initially does not experience any symptoms. In fact, those symptoms might not be noticeable to a person with PD until the time when the brain can no longer help out, or compensate. Dr. Hess hopes his studies may pave the way for better objective tests that could help diagnose Parkinson’s earlier in its course — perhaps even before a person notices any symptoms.

Improving Care

Offering Educational Opportunities to Healthcare Professionals Nurses and physical therapists play a key role in ensuring that people with Parkinson’s have the best possible quality of life. Unfortunately, there is little information on the disease designed specifically for these professionals. PDF believes that offering educational opportunities to healthcare professionals will help ensure better care for people with Parkinson’s.

Our free four-part online course, Parkinson's Across the Lifespan: A Roadmap for Nurses, was designed to address this need and provides the latest in current treatments and care strategies. This course is led by Parkinson’s nurse specialists, physical therapists and people with Parkinson’s. Continuing education credits are available.

In 2011, more than 4,000 nurses from around the world completed the course. This brings the total number of registrants to more than 9,000 since its

launch in June 2010. This course was designed and hosted by PDF in collaboration with the American Parkinson Disease Association and the National Parkinson Foundation.

Building on the success of this course, PDF led the development in 2011 of an online course for physical therapists entitled, Parkinson’s Disease: A Practical Approach to Evaluation and Treatment for the Physical Therapist. This four-part course was designed by expert physical therapists in the field of Parkinson’s and offers updates in best practice for treating people with Parkinson’s. Continuing education credits are available. It was launched in April 2012 by PDF in collaboration with the American Parkinson Disease Association, the American Physical Therapy Association and the Visiting Nurse Service of New York.

“PDF believes that offering educational opportunities to healthcare

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professionals will help ensure better care for people with Parkinson’s.

The PDF Effect: Annual Report 2011 | 15

A

The work of the Parkinson’s Disease Foundation is only possible because of the generous support of numerous individuals, families, foundations and corporations. PDF gratefully acknowledges the following donors who are central to “The PDF Effect” and who are helping us to improve the lives and futures of people touched by Parkinson’s.

Events that Support PDF In 2011, events that supported PDF around the country grossed over one million dollars for Parkinson’s research. In New York City, almost 1,000 people joined together to support PDF by attending one of our three annual events: Bal du Printemps; Celebrate Spring; and Carnaval at the Copa. In total, these events grossed approximately $750,000.

In addition, we were joined this year by over 50 PDF Champions who gave their time and energy to raise awareness of Parkinson's and funds for PDF in A) Herbert Pardes, M.D. and John Thain at Bal du Printemps.

their local communities. These volunteers helped to move the cause forward by organizing pancake breakfasts, joining standup paddle boating events, running in marathons, participating in bike rides and walk-a-thons and by creating their own personalized pages on the PDF website in honor of loved ones with Parkinson's. Their efforts raised almost $300,000.

PDF is very grateful for the efforts of its generous volunteers that have made these events possible.

B) Co-chair Amy Sole and friends at Carnaval at the Copa.

H) PPAC Member Tom Palizzi and family who generously replaced their Christmas exchange with a donation to PDF.

C) Co-chairs G. Pennington Egbert III, Missy Egbert Sheehan and Georgina B. Schaeffer at Celebrate Spring.

I) Family and friends celebrate the life of Ernest G. Spence with a New England-style contradance.

D) Rachel Isenberg and Douglas Briller at Mt. Kilimanjaro.

J) John Morris and friend at his Bicycle Across New York State event.

E) Nicholas Tarallo, Belkis Rosario, Jeffrey Miller, Debra Castiglione and Marc Pillinger at the 6th Annual Pillinger Miller Tarallo, LLP, (PMT) Golf Outing.

K) Edward Barsamian, Cornelia Ercklent and Jeffrey Caldwell at Celebrate Spring.

F) Molly Riddick and friends at the Second Annual Pancakes for Parkinson's benefit.

L) Molly Eger and PPAC Member David Eger at the Ninth Annual Music for Parkinson's Concert.

G) PDF Executive Director Robin Elliott, Board Member Margo Catsimatidis and John Catsimatidis at Bal du Printemps.

M) Pam Quinn and Lucy Roucis at Bal du Printemps.

16 | Our Donors

N) Pamela Strom and Susie Prestie at the first Standup to Parkinson's Race.

Our Donors

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The PDF Effect: Annual Report 2011 | 17

Our Donors

The following individuals, families, foundations and corporations have made cumulative gifts of $500 or more to PDF between July 1, 2010 and December 31, 2011.

Individuals Colman and Nancy Abbe

Harry Bailey

Arnie Bernstein

Andrew Bookout

Kyle W. Abel

Patricia P. Bailey

Daniel and Shelolia Bernstein

Edward C. Booth

Robert and Georgean Abels

Robert and Barbara Baker

Josh Bernstein

Charles A. Bordner, Jr.

Andrew Abramson

Sharon and William Baker

Richard A. Bernstein

Stephanie E. K. Borynack

Andrew and Danielle Abramson

Alex Balanevsky

Neil and Marilyn Bersch

Patrick and Martha Boudewyns

Shirley Abramson

Thelma and Ray Balbes

Mr. and Mrs. David M. Berwind, Sr. Diana Bouton

Leslie J. Acherman

Byrd and Alice Ball

Morris Berzon

Dierdra Bowditch

Stephen and Marsha Ackerman

Florence Barad

David and Jo Anne Bescherer

Grace Bowman

Carol H. Adragna

Sandi Bartel

Beth Besen

James and Michelle Bowman

Dr. Avadesh and Uma Agarwal

Walter Bates

Latchmin Bharat

David Bradford

Sunil Agrawal

Doris Bato

Mr. and Mrs. Alan L. Bibby

Mary Ann Bradham

Mark A. Ahlemann

Peter M. Bauer

Kevin and Debbie Biddle

Sandra Brawner

Roger E. Ailes

Sandra Beal

Louis Bigliani

Bill and Terri Breach

Mr. and Mrs.Thomas S. Alexander Bill and Diane Allen George and Jodie Allen Janet S. Andersen Eric A. Anderson Janet Anderson Mr. and Mrs. Nigel Andrews Joe Andronaco Eric Appelbaum Salvatore Armenio Daniel Armstrong Jeffrey and Shari Aronson Walter E. Arps Mark E. Arroll Simon Asselin Edgar Astrove Shahid Atcha John and Anne Atherton

John and Virginia Beaman

Andrea Billhardt

Michael and Tracess Brenner

Michael and Marcia Beck

Simran Bindra

Carol S. Brewer

Bernie and Wendy Beiser

Jules and Helen Bingham

Hon. Gale Brewer

Mr. and Mrs. Frank M. Bell, Jr.

Maurice and Sarah Birdwell

Irving G. Brilliant

Janet and Lawrence Bell

Lewis Black

Toby Brimberg

Alfonso C. Bellanca

Page Morton Black

John and Patty Brissenden

Marvin Bellin

James Blackorby

Jill and Ken Brodkowitz

Mark Belotz

David H. and Mary B. Blair

Robert and Judith Brody

Dr. Gardner and Patricia Bemis

Cliff and Arlene Blaker

Doug Brown

Don and Carol Bender

James and Carol Blann

Edward and Karen Brown

Tom and Anne Benedict

Moshe Blich

James S. Brown

Alison Benge

Sean and Rosanne Bloodwell

Michael Brown

Robert Benjamin

Herschel and Rita Bloom

Frank A. Bennack

Theodore and Flora Blumenthal

Dr. Russel and Dr. Susanna Brown

Jack M. Berghuis James and Suzanne Bergoffen Donald Berkowitz Martin Berkowitz

Allan Atmore

Deborah Berman and Bruce Greenberg

Norman and Alison Axelrod

Bernard Berner

18 | The PDF Effect: Annual Report 2011

David and Susan Brunell

James Bobo

Nancy F. Brunetti

John and Barbara Bohannon

Gregory Bruns

Richard Bohlen

Bunyan Bryant

Rose-Marie Boller

Amy and Arthur Buckman

Joan R. Bolling

Mr. and Mrs. Mark Budd

D. R. Booker

John and Mary Ann Bumgarner

Klaus and Robyn Burckhardt

Tom and Shwu Mei Chen

Pamela B. Burgess

Kang Cheng

Daniel and Maureen Cummings, Jr.

Michael Donnantuono Christine A. Doyle

Julie Donovan

Nancy Burke

Terry and Brooke Cheng

Mr. and Mrs. William Cunningham

Dr. Robert Burke and Dr. Sharon Wardlaw

Mr. and Mrs. Thomas Cherner

Gene and Judi Curry

Mr. and Mrs. David A. Dray

Shuet-Hing L. Chiu

Barry Curtis

Lyle Drews

Albert and Vera Chrone

Christopher Curtis

Jennifer Driana

Richard Churchill

John Czarnecki

Chris and Jill Drury

Robert and Patricia Caldwell

Wayne Citrin and Deborah Arhelger

Mr. and Mrs. Stephen D'Amato

Mark and Lorraine Duewiger

Marvin S. Caligor

Carol C. Clark, Ph.D.

Mr. and Mrs. Phillip A. Daniel

Richard and Jane Dunbar

Pete Campbell

Aaron and Wendy Clayton

Philip and Mark Danely, Jr.

Bob Duncan

William R. Campbell

Marlynn Clayton

John Danstrom

Harold Dunlap

Joaquin and Angela Campo

Mary Jane and Carleton Cleveland

Mr. and Mrs. Alex Darragh

Roger C. Dunn

Beverly Dashevsky

David and Carole Ebner

Ralph Cline

Diana H. Davis

Brian and Karen Eckhart

Jean Clovis

Mr. and Mrs. Monty Davis

Hollis and Sharon Eddins

Mark Coatney

Ellen R. De Carr

Arthur and Martha Edelstein

Andrew Cochrane

Elizabeth de Lima

Mark Edie

Dr. William Coggshall

Dr. Linton Deck

Loralee Edlund

Norman Cohan

Thomas Y. Deconcilis

Abbie Edwards

Dayl Cohen

Stephen and Kristine Delay

G. Pennington Egbert III Mrs. George P. Egbert, Jr.

James and Debbie Burrows Judy Buyan Peter and Barbara Bye

James M. Cantrell, Jr. Jeff and Dieta Cao Robert and Mary Capaldi James and Mary Jo Capps Karen Card Sharon Cardinal Peter Cardozo Mr. and Mrs. Raymond W. Carlin

Mendel Cohen

Guido D'Elia

Martha B. Carlisle

Gerard Cole, Jr.

Rance and Donna DeLong

Adele Eger

Lisa L. Carnoy

Maureen Coleman

Cynthia Deluz

David and Jane Eger

Ed Carson

Debra M. Collins

Walter Dennis

Ronald A. Eger

Benjamin Carter

Arlene and Walter Cooper

Deborah DePace

Soral Eglowstein

James and Nancy Casty

Mr. and Mrs. Thomas A. Cooper

Anthony DePaolo

Roberta Ehre

Virginia Y. Detoy

Dr. N. J. Ehrenkranz

Max S. Deutsch

Frances Ehrlich

Brett DeWolfe

Robert Eidelberg

Jerry Diamondstein

Charlotte Einstein

Mr. and Mrs. Chris J. Dicharry

Stafford Elias

Mark Dickinson

Robin A. Elliott and Dr. Sheila Gordon

Lee S. Casty Ronald G. Casty John and Margo Catsimatidis Mike and Joyce Caudill Gregory and Amy Cecchi Mr. and Mrs. Bernard D. Chalfin A. W. Chandler George Chang Robert Chang Robert Chartoff Carol and Stephen Chase Mr. and Mrs. Adam Chasnow Howard and Shiow Ling Chen John and Julie Chen

Dr. and Mrs. Frank J. Coppa Katharine T. Cornelius Arnold S. Corrigan Betty Cotton Norman and Helen Coulson Dr. C. W. Cowles Matthew and Janice Coyle Matthew Coz William Cribbin Sally S. Cross Rev. Carol C. Cruikshank Jose R. Cruz Jennifer Csorba

Ervin Dieckhoff Albert L. Diringer Aida S. Dishman Lawrence Dobrow Gary R. Dodman

Patricia and Daniel Ellis Paul Ellis Ernest Ellison II Samuel and Maryann Ellsworth

Kathleen and Eamonn Dolan Mr. and Mrs. Francis Donnantuono

Our Donors | 19

Our Donors

Individuals James A. Emanuele

Russell Furtick

Mr. and Mrs. Benjamin Gomez

Jon and Stevi Gurkoff

Dr. Renee Epstein

Rose Mary and Dan Fuss

Charles E. Good

Andrew Gustin

Steven and Linda Epstein

Ronald and Kroupa Galowich

Richard Goodman

Lydia Gustin

Mr. and Mrs. Jeffery Ettinger

Sarah Belk Gambrell

Dr. Robert R. Goodman

Mark Guzzi

Ellen Fagan

Alan and Marion Garfield

Sarah Goodman

Lois Gwinn

Dr. Stanley and Charlotte Fahn

Diane Garrett

Preston Goodrich

Dr. Ann Rita Hader

Fernando U. Fajardo

Eleanor Gatto

Verma Goodwin

Scott D. Hahn

Paul Falick

Mr. and Mrs. William R. Geist

Alan L. Gordon

Michael Halchak

John P. Falk

Venita Georgieff

Carol E. Gordon

Jeffrey Hamer

Dr. Andrew Farb

Mr. and Mrs. Daniel Gersen

Mr. and Ms. James A. Gordon

William Hamilton

Kenneth H. Fast

Brian J. Gettleman

Stephen Gorny

Charles Hammer

John Fatteross

Helen D. Gibbons

Norma Hammond

Burt and Noelle Faure

Gerald Z. Gibian

Peter John Goulandris and Dr. Karen E. Burke

Gian M. Favalli

Joel Gibson

Leonard and Gloria Fazio

Nora Gibson

Dr. Daniel Feinberg

Robert M. Gilhooley

Barry A. Feldman, D.D.S.

Christopher Gillock

Mr. and Mrs. Paul Feldman

Anthony and Susan Gilroy

George F. Fesko

Dr. Laura Ginkel

Richard Field

Mr. and Mrs. Myron Ginsberg

Philip Fierro

Robert and Gail Ginsberg

Sheldon Fireman

Don S. Ginsburg

Joseph R. Fisher, Jr.

Catherine Giordano

Mr. and Mrs. John J. Fleps

Betty and Max Glass

Richard Gourdeau Mr. and Mrs. Thomas G. Grace, Jr. Stephen L. Graessle Rachel Granger Dr. Michael and Dena Granhof Christine Grant Patrick J. F. Gratton Helen W. Gray Kent Gray Mr. and Mrs. Alan C. Greenberg Betty Jo Greenberger Sherwin Greenwald

William Haney Sulabha V. Hardikar J. Alan and Karen Harding Katie Harms Gilbert Haroche Nancy Harold Steven G. Harper, M.D. Benjamin and Doris Harwell Diane Harwood Don Haslett Mr. and Mrs. Jeffrey Havsy Russell and Wilma Hawk

Margery Z. Flicker

Carol Glickenhaus

Dr. Ann E. Fordham

Stephanie Gluck

Mr. and Mrs. Alan J. Forman

Morton D. Goetz

Cathy Forsberg

Edythe Gold

Dr. and Mrs. Brian Forst

Nancy Gold

Jack Fortinsky

Michael and Anne Golden

Dr. and Mrs. Edward F. Fox

Stanley F. Goldfein

Patrick Franc

Alvin Goldman

Leonard and Jennifer Gruenberg

Jonathan Franzen

Amy Goldman

Nicole D. Guidara

Michael W. Herlihy

Kristina Fresk

James and Sarah Goldman

William and Ruth Gulick

Margaret S. Herold

Geoffrey and Sarah Gund

Philip C. Herr II

Dr. and Mrs. Lawrence Friedman Stephanie Goldman-Pittel and Andrew Pittel Elizabeth B. Friou Dr. Thomas R. Goldsmith Dr. Paul A. Fuchs Jerome Goldstein Mark Funderburk

20 | The PDF Effect: Annual Report 2011

Mr. and Ms. Nicholas P. Greville Mr. and Mrs. John Scott Griffin Andrea Grillini Pete and Emily Gross Sharon Grossman Lillian M. Grossman-Strater

Jimmie and Kurt Hayek Susan Heidenberg Dr. John and Peggy Heilman Jean Kenna Heins Sydney and Roslyn Helfen Mr. and Mrs. Lewis Helfstein Richard and Rose Henneberger Troy D. Henry

Sharyn L. Gunderson

Mr. and Mrs. Stuart A. Hersch

Arlen R. Gunner

Dr. Daniel and Ms. Natalie Hertz

Shelly Guo

Henry G. Herzing

Raymond Hull

Chris and Marnie Kapuscinski

Joel N. Klevens

Mr. and Mrs. Steven Herzog

Helen C. Hutchison

Gary M. Karlitz

George and Jennifer Heseltine

Mr. and Mrs. Mark Indelicato

George Karnoutsos

Dr. David L. Klionsky and Eva Youshock

Steven and Sherry C. Hibshman

Dianne C. Isenberg

Andrew C. Karp

Cliff Ishmael

Richard and Jane Karp

John Isley

Karoly Kasza

Nancy L. Isserlis

Arnold A. Katz

William and Judith Jackson

Steven Katz

Mr. and Mrs. Alan L. Jacobs

Mr. and Mrs. Lawrence Katzman

John Hickey William and Mary Hicks Richard L. Hildbold Mr. and Mrs. Lane M. Hill Majorie and William Hill Sara Hill Jean Hilton Nancy E. Hinkley Mr. and Mrs. Robert F. Hirsch Anna Ho George Hoberg Bryan Hockman Ian Hodgson Monty Hoeflein Elizabeth and Marvin Hoekstra Robert Hoemeke

Randi S. Jacobs Selwyn and Marjorie Jacobs Denny P. Jacobson Ben Jacoby Peter H. Jakes Allan Janoff Richard N. Jayson Judi Jecmen Mr. and Mrs. Arthur P. Jentoft Dean O. Jeynes Donald and Marian Johnson

Randolph S. Klueger James Knowles Suzanne Knowles Edgar and Eileen Koerner Mr. and Mrs. A. Eugene Kohn Shiro Koike Patricia Kolb

Suzanne M. Kavetas

Isobel R. Konecky

Lori Kay

Mr. and Mrs. Robert Kooiman

Paul Kebabian

Kristijan Kordic

Christopher Keber

Cheryl R. Korth

Judithann C. Keefe

Kay Kowitt

Mr. and Mrs. David C. Kell

Mary J. Kraaij

Dr. David L. Keller

Henry E. Kramer

Mr. and Mrs. Lawrence Keller

Phyllis Kravetz

Edward Kelly

Seymour Kreshek

Kathleen D. Kelly

James Kress

Mr. and Mrs. Robert Kennedy

Midge Kretchmer

Jeffrey A. Hoffman

Kevin P. and Laurel E. Johnson-Smith

Arthur and Nancy Kesselhaut

William Krieg

Mr. and Mrs. Neil Hoffman

Mary Johnson

Fadi Khater

Philip and Mary Hogan

Michael D. Johnson

Mary and Franklin Kilgore

Mark B. Kristof and Beth V. Ward

Stephen and Margot Holland

Rhona B. Johnson

Sarah King

Karen Holmes

Thad and Suzanne Johnson

A. E. Kinnison

Alexander Holtzman

Crandall D. Jones

Kaitlyn L. Kinsey

Katherine Hopkins

David and Carolyn Jones

Linda S. Kinzelberg

Sandy and Bruce Horn

Nathanial and Judith Jones

Clarence Kipps

Mr. and Mrs. Jerry Hornstein

Eleanor N. Jordan

John Kirrane

David L. Horwitz

Robert and Sheryl Josephson

Barbara Kirsh

Andrew and Susan Howard and Family

Rosemary Joyce

Stephen Kish

Leslie Kahn

Nicholas Kissel

Sherrie Kaiser

Kevin Kissell

Andrew Kampf

Dr. and Mrs. Francis l. Kittredge

Daniel and Susan Kane

Andy Klein

Zelma Kangas

Gary M. Kleingartner

Henry Kaplan

Mr. and Mrs. Edward Kleinshmidt

Elmer Hsu Deborah and Alan Huber Harold and Pamela Huberfeld Helen Hudgens Patricia H. Huggard Seth Huhnerkoch

Babette E. Krolik Gloria Kronenberg Mr. and Mrs. Rhett Krulla Carol Kuchar Howard and Gail Kunreuther Howard C. H. Kuo Barbara Kyse Patrick LaGrange Louise M. Lallier Lawrence Lam Gordon Lambert Family of Ann and Scott Landes Nancy and Kenneth Landes and Family

Our Donors | 21

Our Donors

Individuals Robert F. Landy

Joan Lipkowitz

David J. Marx

Milton and Cheryl Mill

Mark Lane

Cara Lipshie

Yvonne L. Mason

Mr. and Mrs. Doug Millar

Merry and Martin Lapidus

Mr. and Mrs. Joseph Liss

Catherine and Allan Mathis

Dr. David Miller

Mr. and Mrs. Manuel Larramendi Mark and Judith Litt

George and Priscilla Matouk

Jody Miller

Robert and Susan Larson

Stephen Littman

Mr. and Mrs. Ray Matra

Kendall L. Miller

Roxana Laughlin

Theresa Lo

William and Gail Mattsson

Michael Miller

Robert O. Laven

William Lockeretz

Diane Matusiak

Richard and Lois Miller

Sarah Le Sueur

Marshall Loeb

William and Natalie Mauskopf

Mark Milstein

Mrs. Gene G. Leary

John T. Loftus

Robert M. Maxwell

Pauline M. Lecomte

Bruce and Priscilla Long

Michael and Jessica Mayerson

Eugene and Barbara Miltenberger

So Young Lee

Mr. and Mrs. Douglas Long

William McAlee

Brian Leffler

Gloria Long

Robert and Marsha McCleary

Suzanne M. Leggett

Jim Long

Mark and Gaby R. Lehrer

Mr. and Mrs. Robert Long

Michael and Cynthia McConnell

Mr. and Mrs. Mark Lehrer

Robert D. Lonier

Thomas Lehrer

Gilbert Louzoun

Mike Lein

Dina Lowy

Jill Leinbach

Anthony and Lillian Lu

Laurie Leiner and Morton Katz

Chris P. Lucas

Walter F. Leinhardt

Joseph and Patricia Luetje

Jeffrey and Penelope Leman

Mr. and Ms. Walter Lyczkowski

Johanna K. Lemlech

Hsiang Lin Ma

Jason Lerman

J. W. and Emily Maallister

Dr. Ilan and Dr. Barbara Levi

Marcia L. Mac Harg

Dina L. Levin

Joanne C. MacCallum

Francine and Irwin Levine

Daniel Maddalena

Jerome and Arlene Levine

George R. Mahoney, Jr. and Linda L. Mahoney

Muriel G. Lewis Constance E. Lieber Anita and Stanley Liebowitz Stanley and Susan Liebowitz Mr. and Mrs. William Lifland John and Catherine Liguori Ruth V. Lilley Betsy Lim Mr. and Mrs. William M. Linden Edward and Sylvia Linhares Richard Linhart

Mr. and Mrs. Burton C. Mallory Larry and Janis J. Malone William and Catherine Mandi Ellen H. Manian On-Hou Mar Sidney and Phyllis Margolis Linda Markeloff Rebecca Markley Kay Marmorek Lucille Marquez Sharon R. Marr

22 | The PDF Effect: Annual Report 2011

Everett McCubrey Erin McGarry Cubero Charles McGeown John and Helen McGrath Kevin M. McHugh Dr. Guy McKhann Gordon McLean Charles A. McMellon John P. McMichael Molly McMillan W. McMillin Claire A. McNary

Christina Milton Carol M. Miner Marion and Walter Minton Dr. Martin Mintz and Ms. Cynthia Mintz Alan B. Mirken Zareen Taj Mirza Lawrence J. Misrok Dr. Ena E. Mocega, M.D. Gina Modica Gretta and Lee Mogel Andrea Moletteri John P. Molloy, Sr. Louis Monaco, Jr. Donna Mondani Elena Mondini Christopher Montgomery

Mr. and Mrs. Stephen J. McShane

Jan M. Montgomery

Mary J. Meehan

Mr. and Mrs. George E. Moore

Jane Meeker

Mr. and Mrs. Robert E. Moore

David Melillo

Mr. and Mrs. David Moorman

Merle D. Melvin

Miriam Moran

Dr. Vincent Memoli

Howard and Ginger Morgan

Andrew and Brigittar Menard

Peter A. Morgan

Dr. Robert Mencher

Florence Morris

Robert and Kathleen Menifree

Jay B. Morrow

Craig A. Merdian

Pam Moshe

S. W. and Joan Metcalf

Steve Mount

Joseph W. Metz

Paul V. Mrugacz

Irving G. Brilliant Research Challenge Supporters We thank these contributors to the Irving G. Brilliant Research Challenge 2011 who gave $500 or more and whose gifts were matched by Mr. Brilliant for a total of $400,000 raised for Parkinson's research.

Thelma R. Balbes

Majorie and William Hill

Monica Reed

James and Suzanne Bergoffen

Eleanor N. Jordan

Stephen Reed

Rose-Marie H. Boller

Light of Day Foundation, Inc.

Ezra and Nilofer Reese

Irving G. Brilliant

Mark D. Litt

Henry Richmond

Mr. and Mrs. Mark Budd

Burton Mallory

Sherie Ritzler

Robert Chartoff

Ellen H. Manian

Christopher Rohwetter

William Cunningham

Andrew Menard

St. Jude Medical Center

The DuBose Family Foundation

MetLife Alico

Stan M. Sandberg

Bob Duncan

Joseph W. Metz

Paul Ellis

Marion Minton

Arnold and Marie Schwartz Fund

Epstein, Becker & Green, P.C.

Andrea Moletteri

Ferguson Family Trusts

Sunil Nayar

John W. & Laura S. Stewart Foundation

Ronald H. Galowich

Robert Northington

Rebecca C. Swan

Stanley F. Goldfein

Dorothy S. Oda

Martin Typer

Preston Goodrich

Rick Oddo

U.M.R. Foundation

Wilma P. Hawk

John and Marnie Olson

Mark Viviano

Clyde W. Smith

Michael Opalak

Diane M. Mueller

Maggie Nicholas

Terrence C. O'Bar

Michael Opalak

Kenneth N. Munsen

Pearl Nicholls

Bernice S. Oberndorf

James Orsini

Mr. and Mrs. Michael Murphy

Magda Nieuweboer

Mr. and Mrs. George O'Connor

Neal Ortenberg

Elizabeth Murray

Sally L. Nightingale

Thomas and Dorothy Oda

Debra Osburne

Kenneth Musen

Agnes Nixon

Rick Oddo

Mila A. Ostin

Frances F. Musser

Jim and Marla Nock

Debra Oden

Don Oswald

Jean Myers

Edward J. Noha

Robert Ogden

Melissa Nace

Lloyd Noland

Kathleen O'Grady

Mr. and Mrs. Robert Paglia and Family

Sarita Narson

Robert Northington

Christopher and Lilla Ohrstrom

Paul and Marcy Nathan

Sabato Noto

Carol Okane

Sunil Nayar

Allan Novak

Aksel Olesen

Douglas C. Nelson and Jean A. Douglas

Mr. and Mrs. Eugene A. Nowell

Donald Olson

Carol Noymer

John and Marnie Olson

Mr. and Mrs. Lawrence C. Nussdorf

Mr. and Mrs. Timothy Onders

Ruth K. Nelson Bernard and Sandra Newman

David and Judy Pahren Arthur Palik Tony Pallagrosi James Palmer Dr. Pasqual J. Pantone Blaine Parkin and Maralee Chase Parkin

Our Donors | 23

Our Donors

Individuals Alan Patricof

Frederick Prince

Dawn Roberts

Hellyn L. Sarek

Hugh L. Patterson

Ronald D. Provost

Mr. and Mrs. Jeffrey D. Roberts

Lawton Sargent

Randall and Mary Payne

Dana C. Puddy

Thomas and Brenda Roberts

Scott Sassa

Sandy Payne

Bhaskar Pulikal

David Robinson

Melba Pearlstein, Esq.

The Roland T. Quade Family

Sally Robinson

Mr. and Mrs. Gary Satterthwaite

Dr. and Mrs. Timothy Pedley

Marjorie Quaife

Dr. Jean-Christophe Rochet

Deborah Pelle

William Rabbe

Karin Rodgers

Val R. Pemberton

Mickey and Ellen Rabina

Hazue T. Rogers

William S. Penick

Jeffrey Rabinowitz

Fritz Rohrlich

John C. Pepples

W. Matt and Amelia Ralls

Christopher Rohwetter

Shirley Perez

Gerald and Barbara Ranzal

Robert and Heddie Romanoff

Theresa D. Perl

Cathy Raphael

The Romero Family

Dr. Carolyn Perla

John Raphael

John Rosecky

Harvey and Irene Pessar

Debra Raskin and Michael Young

Mark Rosen

Dr. Neil Schiff and Patrice L. Schiff

Charles A. Rosenbaum

Keith E. Schilder

Mr. and Mrs. Frank A. Petitti George Petras Col. and Mrs. John Phelps

Michael and Kristin Reed Dr. Monica Reed and Stanton Reed

Eleanor and Richard Phillips

Stephen Reed

Stephen and Patricia Pickering

Mr. Ezra and Dr. Nilofer Reese

Donna Pickett

Ralph and Barbara Reis

Colin G. Pitt

Aleks and Stacy Renshaw

Nina Platt

David and Nancy Resnick

Carol Pogash Marilyn J. Polansky

Andath L. Saunders Daniel C. Savitsky Anand R. Savur John and Deborah Scanlon Mr. and Mrs. David S. Schaefer Donald A. Schaefer Heather Schaefer Matthew J. Schaeffer

Jean Rosenberg

Susan Schindler Mr. and Mrs. Edward Rosenblum Steven Schirripa Carol Rosensweig and John Schlarbaum Charlene D. Grant Dr. Gregory and Melvin S. Rosenthal Patricia Schlegel David and Nadine Ross Dr. Herbert Schlesinger Dr. Harley A. Rotbart

Carole Schlessinger

Dr. Margaret E. Rice

Dr. Deborah C. Roth and Jack Roth

Robert E. Schmitt

Harold V. Richard

Melissa Roth

Anthony and M. Allison Richards

Mr. and Mrs. Steven Rourke

Richard and Anita Pollak Ruth Pollack and Martin Bressler

Paul and Tanako Richards

Deborah Pollard

Henry and Renee Richmond

Sheng-Shung Pong

Mr. and Mrs. Alan B. Richstein

Carlyn G. Poole

William and Sandra Richter

Mr. and Mrs. Henry A. Pope, Jr.

Drs. John and Susan Pollack

Dr. and Mrs. Lewis P. Rowland Robert Rozak

Fredrick and Karen Schneider Marriane Schnell Jay and Suzette Schochet Charles and Kathren Schreck

Hedda Rublin

Dr. Thomas J. and Jean Schreiber

Carl Russell

Michael Shrimmer

Mr. and Mrs. Michael A. Riddick

Ken W. Ryder

Mr. and Ms. Craig Schrock

Jamie Saccardo

Shelley and Blair Schrum

James and Sandra Porter

Sandra L. Rigopoulos

David M. Schuld

Louisa and Henry Porter

William F. Ringier

Mr. and Mrs. Paigualina Sacchetti

Margaret Posthumus

Frank Ritchey

Ruth Ann Potts

Sherie Ritzler

Dr. Matthew Power Arjun Prabhu

Drs. Lawrence J. and Carol L. Rizzolo

Jack and Pamela Preston

Brenda G. Roberts

24 | The PDF Effect: Annual Report 2011

Steven B. Sadler Albert and Jane Safer Saul M. Salka Stan M. Sandberg and Stacey J. Mayesh David Sands

Brian and Kathy Schultz Eric Schwartz Howard and Phyllis Schwartz Marie D. Schwartz Martin Schwartz Max and Nancy Schwartz

James Parkinson Legacy Society We thank these members of the James Parkinson Legacy Society who have included PDF in their estate plans or have established a charitable gift annuity with us.

Gertrude S. Bell

Matilda Goodman

Mr. and Mrs. Robert W. Smith

Roger M. Bowman

Eleanor N. Jordan

Charles L. Thomas

Ann Cavalli

Annette Korn

Lucy Veneble

Aila G. Dawe

Viola B. Marshall

M. R. Weingardt

Jean Dewdney

Edith Perman-Allen

James B. Wittrock

Guy Estes

Marie D. Schwartz

Elizabeth A. Geiser

Stephanie and Bernard Schwartz

If you have made estate plans which include PDF or wish to establish a charitable gift annuity which provides you with income for life, please contact Eddie Pelto, Director of Development, at (800) 457- 6676.

Dr. Regina Schwarz and Dr. David Aftergood

Dr. and Mrs. Thomas Shiftan

Dr. and Mrs. Bernard E. Small

Alice M. Starr

Gary I. Shimoda

Alexa Smith

Roger and Marianne Staubach

Mr. and Mrs. Frederick Schwarzmann

R. L. Shoemaker

Clyde W. Smith, Jr.

Carolyn Stearns

James and Susan Show

James Smith

Carol Stegink

Thelma J. Scott

Rose L. Shure

Kathryn Smith

Joel and Kathy Segall

Stanley Sidel

Steve Smith

Dr. Philip Stein and Bonnie Stein

Ethel Seife

Ms. Janice Siegel and Dr. Lloyd Marks

Mr. and Mrs. Marcellus Snow

Ethel L. Schwarzman

B. Semmel Edward and Cynthia Seretan Dr. William D. Severinghaus and Mary C. Severinghaus

Arthur and Dr. Sandra Siler Julie Silva David Silverman

Mr. and Mrs. Paul W. Snyde, Jr. B. Robert and Mary A. Snyder Glenn Snyder

Rita R. Steinberg Gail Stelter Jonathan and Sydney Stern Louis and Freya Stern Russell and Meryl Stern

Paul Silverman

J. Clifton Snyder and Lillian Gordon Snyder

Brenda M. Shapiro

Mr. and Mrs. Mark K. Silverstein

Amy Sole

Todd D. Stewart

Jerome Shapiro

Robert and Kathleen Simione

Dr. Stanley Sollie

Mr. and Mrs. Abbott Stillman

Leslie C. Shapiro

Ian Simmonds

Dr. and Mrs. Marvin Solomon

Ronald and Evelyn Shapiro

J. Robert and Linda Sims

Phyllis Sonnega

Dr. Alvin M. Stinson and Annette Stinson

Candy G. Shaw

Phillip S. Sirianni, Jr.

Douglas Spaniol

Rev. F. Barry Stipp and Colette Stipp

Felice K. Shea

Samuel J. Sirota

Stacie Spector

Scott Strickland

Dr. Sam Shelanski

Arline B. Slepoy

Sue Sperger

Warren and Frances Stricoff

Debbie J. Shepherd

Catherine Slivinske

Jerry I. Speyer

Richard Strobel

Roger and Ewanna Sherburne

Jeffrey Sloan

Joseph and Louise Spiezio

John Sheridan

Mr. and Mrs. Richard Sloan

Earl and Dolores Spurrier

Christianna L. Strohbeck and Dr. Ramaswamy Murari

Jack and Paula Sherman

John F. Slusser

Matt and Barbara Stanek

Lindsey Strubhar

Douglass and Julie Shands

Sandra and Evan Stern

Our Donors | 25

Our Donors

Individuals Alberto and Lynda Ann Strulovic Francine Turk

Evelene Wechsler

Pamela Yin

Yves T. Struye

David and Sharon Turner

Audrey and John Wee

Beverly Yoder

Jessica Stuart

Martin Typer

James M. Weichert

Susan and Nathan Yost

Christopher and Mary Jo Studwell

Dr. Richard and Gail Ullman

Kenneth and Susan Weil

Jeanne Young

Rodolfo Urbina

Andrew Weinrich

Larry Young

Sharon Sturges Laura Sudar Vivian and Charles Sukenik Anthony and Sylvia Summa Ram and Preethi Sundaram Rebecca C. Swan James and June Swartz Edward and Nancy Sweeney Diane Swonk Kevin V. Symmons Laura J. Taff Charles Talcott James and Mary Talmage Gordon Tannura Catherine Targowski Carol and Melvin Taub Mary Elizabeth Taylor Michael Tedesco Louis Teitelman and Family Nathan and May Teitelman Rocky and Cindy Terrel John and Carmen Thain Ann Thompson

Johanna M. Utrecht

Herbert and Judith Weintraub

Peter M. Young

Lester and Antonette Vaccari

Sally W. Weintraub

Kathy Younkins

Louis Vaccaro III

Mr. and Mrs. Bernard W. Weiser

Pat Younts Lou and Gail Zaccheo

Russell and Whitney Van Nuis

Beverly Weiser

Leslie Van Meir

Dr. James Weiss

Jed and Brenda Zachs

Benjamin and Deborah Varat

John Wellsandt

Edward Zajac

Craig Varrelman

Delores E. Westphal

Rose Zaretsky

Mr. and Mrs. Jeffrey D. Varsa

Nancy M. Wheeler

Christine Zeisler Mr. and Mrs. Robert Zelnick

Yvonne Vasicek

Jennifer and Robert Wheelock

Marshall Vass

Lawrence E. White

Mr. and Mrs. Robert M. Zemsky

Richard N. Vaughan

Pamela White

Judy Zendell

Mary Ann Veitch

Mary Wiebke

Louis G. Zimmerman

Renzo Vescio

Robert and Sherry Wiener

Cynthia Zirinsky

Edward M. Vietor

Robert and Carol Wilder

Melvin and Esther Zirkes

Joseph Virgilio

Jeffrey and Lise Wilks

Donald and Lynn Zucker

Mark Viviano

Kenneth and Kimberly Williams

Susan Zwick

Frederick and Toni Von Zuben

Wendy Williams

Matthew and Sonja Vorwald

Dr. Philip J. Wilner

Jules and Florine Wachter

Kenneth R. Wilson

Richard and Cheryl Wade

Belinda Windsor

Doris C. Wages

Dorothy Winkey

Mr. and Mrs. Alan S. Waldenberg Michael Witter Dan Walsh

Joel Wojnilower

Regina Wang

Adam Wolfberg

Melvin and Charlotte Timm

Mary Wardell

Ann Wolfe

Mr. and Mrs. David Timony

Audrey Warfield

Eve Wolff

Zane G. Todd

Sandi Wasch

Fred and Mary Woodlief

John and Patricia Toebe

Lori L. Wasserman

Rosalind Woolf

Maureen Tokar

Toshi Watanabe

Walter E. Woolsey Dave Wopat

Mr. and Mrs William S. Thompson

Mr. and Mrs. David Tolli

John W. Watkins

Rhonda Tomashefsky

Eliot R. Wax

Terry and Karen Wright

Alison Torres

Betty Weber

Jerome and Selma Yaguda

Marshall and Gloria Tucker

Jane and James Webster

Yi Tien Yang

26 | The PDF Effect: Annual Report 2011

PDF Champions We thank our PDF Champions whose efforts from July 1, 2010 to December 31, 2011 helped us fund promising research and also raised awareness in communities around the US. 3 4 Fighting PD

June Keszeg

Alethea Bancale – Niagara Falls

James Knowles

International Marathon

Diane Banks – Sycamore Hills Golf Fundraiser

Natasha Brown Tomee Brown Gary Chard – Gary's 60th Birthday Party Matthew Coz – Burning River 100 Mile Endurance Run

Lindsay Borsack Cruz – More Magazine Fitness Half Marathon

Tammy Kozumplik – Cut-a-Thon Ivory Latta – 1st Annual Ivory Latta Celebrities for Parkinson's

Adrienne, Peter and Miranda Lee Rachel V. Loeser

Molly Riddick – Pancakes for Parkinson's Benefit

Teresa Riffle – Circleville, OH Walk for a Cure

Michael Roush – Parkinson's Walk for a Cure/In Memory of Lloyd Roush

Frank Rumoro – 1st Annual "Stepping Out" Fundraising Walk

Jill Markey – Doug's Wild Ride

Wendy A. Schreiber

Julee Masters – Cakes Creations and Co

S. Jane Schrick

Charles F. McGeown – McGeown Golf

Michael Showstead – Phillips Boston

Tournament

Banquets

Jason Davis – Bill Lowery Memorial Fund

Kayla McKibben – Dancers Who Care

Julie Silva – San Francisco Half Marathon

Brian DeFord – DeFord Mountain Hike

Kristian Melby – NYC Marathon

Angela Sipes

Maria De Leon, M.D.

David P. Melillo – Zwick Pro Am Golf

Kathy Smith – Change for Parkinson’s

Cindy DeLuz Deana DeModena

Tournament

Jesus John Scott Michael – Poker for Jesus

Megan Smith Bella Somelofske – Newport, RI Marathon

Brett DeWolfe – Iron Man Challenge

Greg Mocarski – Running for Faye

Linda Spence – Ernie's Favorites

Naomi Diep

John Morris – Bicycle from Montauk

Mel Stewart – Cape Epic

Theresa Donahoe John D'Onofrio David J. Eger, Ph.D. – Music for Parkinson's Research

Point to Niagara Falls

Lori Morrow – Chicago Marathon Paul V. Mrugacz – Chili Cook Off Denise Mullineaux

Jeni Forshier-Jenkins – Shuffle and Shake – Parkinson's Awareness

Jennifer Neathery – Neathery Nashville

Ashley Garrett

Tom Palizzi – Tom Palizzi and Family

Antoinette & Ken Geraci Linda Giorgilli-Rice John Gollisz

Marathon Holiday Giving

Parkinson's Support Group of the Mid-Hudson Valley Inc – Walk Over the Hudson

Pamela Strom – Stand Up to Parkinson’s Race

Danielle Surace – Vincent Fillingeri Memorial

Carol Tahsuda Pillinger Miller Tarallo, LLP Cynthia Taylor Doris Vasquez K. C. Veitch – Kappa Delta Phi Sorority/ Sigma Pi Fraternity

Alexandria Gorski – Gorski PD Month

Marina Parrish

Linda Walsh – Run In Honor of Dad

Andrea Grillini – Car Wash For PD

Jim Patterson – Pints for Parkinson’s

Emily Walter

Hillary Hackett – Wake Forest Run/Walk

Crystal Penney – Wedding of Crystal

Madelyn Weingart and Alison Magistrali

in Honor of Uncle Barry

& Tom

Jay Hebert – Parkinsons In the Park

Rita Peters – Oklahoma City Marathon

Clayton Henderson Memorial

Lisa Piccirillo

Michael Hornung – Splash for a Cause

Debra Pinon

Rachel Isenberg – Half-Marathon

Tanya Puckett – Albany, GA Marathon

Philadelphia; Pittsburgh to Philly Bike; Mt. Kilimanjaro Climb

Randi S. Jacobs

Deb Rabinowitz – Every Day Sundays with Mollie

Becky Jarnagin

Alexander Ranieri and Kristina Mazzone – Long Island Half Marathon

Elizabeth Keshish

Don Rempher – Hiking the Pacific Coast

Brittany West – Find a Cure in Our Lifetime

Gillian Woods – Keeping the Pace with PD: NW Arkansas

Yacso-Meyer – Stuart Meyers Champions Event

Pat Younts – Pat Younts Versus Parkinson's Golf Tournament

Zogsports – Zogsports Play for a Cause

Our Donors | 27

Our Donors

Foundations/Corporations/Organizations A&M Label

BlackRock Kelso Capital

Abbott Laboratories

The David H. and Mary B. Blair Charitable Fund

ADM Information Services Kenneth Aidekman Family Foundation

BNSF Foundation TX

Louis and Virginia Clemente Foundation, Inc.

Eli Lilly and Company Foundation, Inc.

The Clorox Company Foundation

Encana Oil and Gas (USA), Inc.

The Betsy and Alan Cohn Foundation, Inc.

Epstein, Becker and Green, P.C.

Epic Systems Corporation

Employees Community Fund of the Boeing Company The Shana Alexander Charitable Foundation Bonner Family Private Foundation, Inc. Alexandra and Martin Symonds Foundation, Inc. Booz | Allen | Hamilton

Jerome and Ilene Cole Foundation, Inc.

Ernst Foundation, Inc.

The George Coleman, Jr. Foundation

The George and Jodie Allen Charitable Fund

Arthur and Eve Fastenberg Philanthropic Fund

Bowman, Monaco and Black, PC

Simon and Eve Colin Foundation, Inc.

Ferguson Family Trusts

Bristol-Myers Squibb Company

Colligas Family Markets, LP

Feuerring Foundation

Brookhill Planning, LLC

The Color Fund

Fidelity Charitable Gift Fund

Brooklyn Mechanical Corp.

Columbia University Medical Center

Firstgiving, Inc.

Brown Charitable Foundation

Community Health Charities

Amicus Therapeutics

BT Americas Corporate Matching Funds

Consumer Electronics Association

Forest Family Foundation

Apple Matching Gifts Program

Budwitz and Meyerjack, PC

Cox Communications

Applied Materials

Burgundy Foundation, Inc.

The Connie Frank Foundation

CSX Corporation

Archer and Greiner, P.C.

The Caliban Foundation

Fred Siegel Foundation

AT+T United Way

California Community Foundation

Cumberland Community Foundation, Inc.

The Fremont Foundation

Edna Williams Curl and Myron R. Curl Endowment for Parkinson's

GE Foundation

Allstate Giving Campaign The Allyn Foundation, Inc. Altria Matching Gifts Program American Society of Appraisers America's Charities

The Atmos Foundation Automatic Data Processing, Inc. BAE Systems The Bane Foundation Bank of America Bank of America United Way Campaign Bart and Associates, Inc. Alvin H. Baum Family Fund Beck and Masten Buick-GMC, Inc.

Boucher Charitable Foundation

Cambrex Corp.

Campbell, Inc. Canata Family Foundation

The Dana Foundation

DCH Montclair, LLC D/B/A Cardinal Engineering Associates, Montclair Acura Inc. Diamantine Family Foundation, Cardinal Health Foundation Inc. Caribbean Enterprises, Inc.

The Dinan Family Foundation

Castle Harlan, Inc.

Eamonn and Kathleen Dolan Charitable Fund

James and Nancy Casty Charitable Foundation Lee S. Casty Philanthropic Fund

Don Ayers Pontiac

Fairchild Martindale Foundation

Harriet Ford Dickenson Foundation Fox Family Charitable Trust

Gap, Inc. Giving Campaign General Electric Co. Give With Liberty Ruth and Jack Glantz Family Foundation Inc. Glickenhaus Foundation Joseph H. Goldberg Family Foundation Edward and Marjorie Goldberger Foundation Goldman Sachs Gives Sol Goldman Charitable Trust

The Bendheim Foundation

Ronald G. Casty Family Foundation

The Dopkin-Singer-Dannenberg Foundation, Inc. Dorf Associates

The Berner Charitable and Scholarship Foundation

Cedar Grove Lutheran Church

Google Matching Gifts Program

Dreiseszun Family Foundation

Cemex Materials, LLC

The DuBose Family Foundation

The Samuel and Grace Gorlitz Foundation

Check Point Software Technologies

Dupont Systems, Inc.

Lee Gottlieb Fund, Inc.

Eagel Sports Promotions, Inc.

The Gottwald Foundation

Echlin Foundation

The Tom and Bonnie Grace Family Foundation

Bell-Mark Sales Company, Inc.

Big Y Foods, Inc. Biotechnology Industry Organization Bisgeier Family Foundation Page and William Black Foundation

Terry Cheng Gift Fund The Cimino Group, Inc. Citizens Bank

28 | The PDF Effect: Annual Report 2011

El Paso Corporation

Gracie Square Hospital

Grand Council of Cryptic Masons

Dr. Rudolph and Mildred Joseph Foundation

William and Nancy Lifland Fund

Grand Chapter O.E.S.

Just Give

Light of Day Foundation, Inc.

Mabel Burchard Fischer Grant Foundation

Greater Kalamazoo United Way

Litterman Family Foundation

The Kandell Fund

Loeb and Loeb, LLP

Jerome A. Kaplan and Deena L. Kaplan Family Foundation, Inc.

Lovinger Family Foundation

Sally Nightingale Charitable Fund

Macquarie Bank, LTD MAERSK, Inc.

H&R Block

Fred Kassner Family Foundation

Nine Thirty Capital Management, LLC

The Gwendolyn HalseyAlbertson Foundation

Kastle Greens Corp.

Ann S. and Albert L. Maltz Foundation

Eugene and Emily Grant Foundation The Jack Webster Grigsby Foundation

Harrah's North Kansas City, LLC

Robert and Florence Kaufman Foundation, Inc.

George W. Harris Foundation

Harry L. Kavetas Family Fund

The Harte Auto Group

Kelly Refrigeration and Freezer, Inc.

Mahoney Donor Fund

Mar-Ber Development Corp.

Mazur, Carp, Rubin and Schulman, P.C.

New York Presbyterian Hospital The New York Times New York University New York Yankees Foundation

Employees Charity Organization of Northrop Grumman Northwest Hills Credit Union Northwoods League Foundation

McCormick Company, Inc.

The Calvin Flavia Oak Foundation, Inc.

Kelly Family Foundation

The McGraw-Hill Companies

Thomas P. and Patricia A. O'Donnell Foundation

Leona M. and Harry B. Helmsley Foundation, Inc.

Kesselhaut Family Foundation

Medtronic, Inc.

Elmer P. Kinnamon Trust

Office Automation Systems

Merck Partnership For Giving

HighVista Strategies, LLC

The Richard E. and Marianne B. Kipper Foundation

Ogden Cap Properties, LLC

MetLife Alico

OH Local

Sam W. Klein Charitable Foundation

Microsoft Giving Campaign

Richard and Harriet Orkand Charitable Fund

Hauser Family Foundation, Inc. The Hearst Corporation

IHS Foundation Homestead Foundation, Inc.

Sharon Klein Graphic Design

Mid-Atlantic Center for the Performing Arts

Kniffin Family Foundation

Midstate Radiology Associates, LLC

Regina Pargament Trust Fund

The Kortschak Family Foundation

The Millison Foundation

Parkinson Network of Mount Diablo

The Kosher Nosh

The Mirapaul Foundation

Parkinson's Unity Walk, Inc.

The Kraus Family Foundation

Jeffrey Modell Foundation, Inc.

Isermann Family Foundation

Seryl and Charles Kushner Family Foundation

Morgan Stanley

Hyman and Bessie Passman Family Charitable Foundation, Inc.

Isidore C. Myers-Joseph A. Erickson Properties, Inc.

Latham and Watkins, LLP

Mount Sinai Hospital

Lawrence Livermore National Laboratory

Nanell Foundation

Hortley G. Leblang Charitable Trust

Thomas Neal Foundation, Inc.

Honeywell International Charity Matching Gift Program IBM Employee Services Center Independent Charities of America ING Charitable Giving Program Ipsen

The JCT Foundation J. M. Smucker Company Jacoby Family Fund

Motorola Foundation

National Sound Industries, Inc.

PEC United Charities, Inc.

Patton Holdings, Inc. PBM Products Pearson Education Pfizer Foundation Matching Gifts Program

The Janus Foundation

Legatus Foundation

The Netter Foundation, Inc.

Pfizer, Inc.

Jewish Communal Fund

Dana and Jesse Lehman Foundation

Network Consulting, Inc.

PG&E Corporation

John Wojtowicz, Inc.

Network For Good

The Eileen and Peter Lehrer Family Foundation, Inc.

The New York Community Trust

Philip Holzer and Associates, LLC

Anita and Stanley Liebowitz Fund

New York Life Insurance Company

Johnson & Johnson Family of Companies Jordan Family Foundation

The Phillies Davis Phinney Foundation

Our Donors | 29

Our Donors

Foundations/Corporations/Organizations Pillinger Miller Tarallo, LLP

S&S Realty

Suplove, Inc.

Pitney Bowes Employee Giving Program

SAD Foundation

Henry and Marilyn Taub Foundation

Play For Your Cause The Bernard Plotkin Fund The Portmann Family Charitable Fund Premiere Paddle Surf

Edmond J. Safra Foundation Sanky Communications, Inc. Schering-Plough The Jean and Thomas Schreiber Philanthropic Fund

Shirley Waldbaum Witkin Foundation, Inc. Wasily Family Foundation

Judy and Warren Tenney Foundation

Weiden Schwartz Fischler Family Foundation

The David Tepper Charitable Foundation

Weill Cornell Medical College

Teva Neuroscience, Inc.

J. Weinstein Foundation, Inc.

The David C. and Jeannie Price Fund

Schulte Roth and Zabel, LLP

Three Swallows Foundation

Wellpoint Associate Giving Campaign

Schwab Charitable Fund

Prince Charitable Trusts

Phyllis and Howard Schwartz Philanthropic Fund

Timber Creek Capital Management, LLC

Wells Fargo Community Support Campaign

Tishman Speyer Properties, LP

Wellspeak, Dugas and Kane

Quadel Consulting Corp.

Qualcomm Matching Gift Program R.A. Novia and Associates, LLC R.C. Bigelow, Inc. Ralph J. Duffie, Inc. Razoo Foundation Red Apple Group Kristin and Michael Reed Family Foundation, Inc. Regions Morgan Keegan Trust The Donald Reich Family Charitable Fund Re-Steel Supply Co., Inc. Retired Public Employees Association of California

Arnold and Marie Schwartz Fund

TJM Investments

WESTAT

Secure Real Estate Management, LP

Toshiba Business Solutions

Westchester Hills Golf Club

Truist

Mark and Muriel Wexler Foundation

Semmes The Shafir Family Fund Leslie C. and Leonard A. Shapiro Family Foundation, Inc. The Ron Shapiro Charitable Foundation

The Trukenbrod Family Foundation Tumi, Inc. Turnaround Management Association UCB, Inc.

The Shubert Organization, Inc.

Richard and Gail Ullman Charitable Fund

Siegel, O'Connor, O'Donnell and Beck, PC

The Ullmann Family Foundation

The Sierra Fund The Oscar and Edith Simon Foundation

U.M.R. Foundation United Refining Company United Technologies

The Herbert and Arline Slepoy Charitable Fund

United Way of Central Indiana, Inc.

Smith Haven Ministries, Inc.

United Way of New York City

Society of the Transfiguration

United Way of Rhode Island

Ropes and Gray, Inc.

The Spurlino Foundation

United Way of Somerset County

Eli and Mae Rosen Foundation

St. Irene's Philoptochos Society

United Way, Inc.

Joseph Rosen Foundation

St. Jude Medical Center

U.S. Charitable Gift Trust

The Benjamin M. Rosen Family Foundation

Frank and Domna Stanton Foundation, Inc.

The V & L Marx Foundation

Rheem Manufacturing Company The Andrew and Lisa Rodman Foundation

The Irene Herbert Ross and John W. and Laura S. Stewart Harper Grant Ross Foundation Foundation Ross-Kolmerten Fund Royal Neighbors of America Dianne H. Ruthman Family Foundation

Vanguard Charitable Endowment Program Visa Givingstation

The Dorothy Strelsin Foundation

Vision Equities, LLC

Sullivan and Cromwell, LLP

Wachovia

Sullivan Solar Power

30 | The PDF Effect: Annual Report 2011

The Wheeler Family Foundation WithumSmith + Brown The Yaspan Unterberg Foundation, Inc. Zankel Charitable Lead Trust Mary and George H. Zimmerman Foundation Zoe's Best Friend, Inc.

Planned Giving Estates

Planned Giving Trusts

Succession of Verble Mary Augustine

Isabellea M. Amell Revocable Trust

Joseph M. and Eva M. Perasso 2000 Trust

Gloria Broward

Evelien Auerhamer Trust

Powers Revocable Trust

George Bruno

Adele Blank Charitable Lead Trust

Elizabeth Kellogg Crouch J. B. Daiches

Dorothy M. Booth Charitable Trust

Richard P. Rost Trust Esther Ruddick Trust Frances Marie Smith Revocable Living Trust

Nelson C. Doland, Jr.

BettyLou Burton Trust

Lillian Dursht

Mae C. Clegg Trust

Ernest C. Geiger

Ruth D'Atri Trust

Lester W. Stevenson, Jr. Trust

James C. Harnden

Trust of Edith Eisler

Esther Stykel Living Trust

Ruby Jefferson

Lida Ferguson Testamentary Trust

Esther Wright Trust

Dorothy Bauer Jochem Anthony Klempa

Gladys Field Charitable Lead Annuity Trust

Dolly Koler

Dorcile R. Fowler Trust

Marie Langlois

Evan A. Fradenburgh Trust

Kenneth W. Law

Millie & Jesse Fusfeld Charitable Trust

Virginia N. Lowry Irene M. Matto Appolonia Mayer

Bettie D. Gallagher Irrevocable Trust

John D. Mazzarella

Annette Goodrich Revocable Trust

Paul Edwin Melcher

Hudson Charitable Trust

Joan P. Metcalf

Gladys T. Hyman Trust

Velma R. Nagel

Charles Irwin Trust

John J. Robinson

J. Bert Jones Trust

Anne J. Schaff

Rose A. Kalns Trust

Florence Schwartz

Kniffin Charitable Remainder Trust

Helen Sisko Lawrence Stchur Martha Valchich Irene A. White Allyne Whitlock M. R. Wiegandt Edward Zotter

Wesley L. Southerland Revocable Living Trust

Trust of Virginia Ladensohn Toni Lieberman Family Charitable Trust Margaret D. Lienemann Charitable Trust Irene M. Matto Trust Gordon McLean Trust Trust of L. M. McOmie Henry A. Morris and Marian C. Morris Revocable Living Trust The Melba M. O'Connell Trust

Our Donors | 31

In 2011, PDF awarded $5.5 million for Parkinson’s research. This included 40 awards for projects and mentored fellowships initiated by individual investigators from the global scientific community and collaborative projects conducted by research teams at major institutions. We thank the following grant recipients for their commitment to improving the lives and futures of people touched by Parkinson’s.

Center Grants | $2.62 Million

International Research Grants | $825,000

Allow talented scientists the flexibility and long-term support to collaborate on basic, translational and clinical research.

Promote innovative research projects that have high potential to significantly advance the knowledge of Parkinson’s.

Columbia University Medical Center Roy N. Alcalay, M.D., Robert Burke, M.D., Lorraine N. Clarke, Ph.D., Stanley Fahn, M.D., Blair Ford, M.D., Lloyd Greene, Ph.D., Paul E. Greene, Ph.D., Elan D. Louis, M.D., M.S., Karen Marder, M.D., M.P.H., Pietro Mazzoni, M.D., Ph.D., Serge Przedborski, M.D., Ph.D., Seth Pullman, M.D., Yaakov Stern, Ph.D., David Sulzer, Ph.D., Jean Paul Vonsattel, M.D., Cheryl Waters, M.D., Nancy Wexler, Ph.D., Ai Yamamoto, Ph.D.

Evaluating the Role of Mitochondrial Dynamics in Parkinson's Disease in an In Vivo Vertebrate Model: Real-Time Live Imaging of Mitochondrial Dynamics in Dopamine Neurons in Whole Zebrafish Sarah Berman, Ph.D., M.D., and Edward Burton M.D., D.Phil., F.R.C.P., University of Pittsburgh Impact of Low- and High-Frequency Electrical Stimulation on the Inputs, Integrative Properties and Output of the Subthalamic Nucleus Mark Bevan B.Sc., Ph.D., Northwestern University, Chicago

Rush University Medical Center Telomere Biology in Patients with Incident Parkinson’s Disease* Tobias Kurth, M.D., Sc.D., and Robert Y. L. Zee, Ph.D., M.P.H., Brigham and Women’s Hospital, Boston

Brandon R. Barton, M.D., Bryan A. Bernard, Ph.D., Cynthia L. Comella, M.D., Jennifer G. Goldman, M.D., M.S., Christopher G. Goetz, M.D., Deborah A. Hall, M.D., Katie Kompoliti, M.D., Jeffrey Kordower, Ph.D., Kathleen M. Shannon, M.D., Glenn T. Stebbins, Ph.D., Leo Verhagen, M.D., Ph.D.

Identification of Neuroprotective Factors in Tobacco* Leo J. Pallanck, Ph.D., University of Washington

Weill Cornell Medical Center M. Flint Beal, M.D., Claire Henchcliffe, M.D., D.Phil., Melissa J. Nirenberg, M.D., Ph.D.

Small Aromatic Molecules as Novel Inhibitors of Alpha-Synuclein Aggregation Daniel Segal, Ph.D., Tel Aviv University, Israel

Additional Research Programs | $189,000 Fund innovative collaborative programs, such as the Advancing Parkinson’s Treatments grant to the Parkinson Study Group to facilitate the movement of treatments from “bench to bedside.”

Identification of Genes for Parkinson's Disease in an Isolated Greek Community and a Greek Population Cohort Georgia Xiromerisiou Ph.D., M.D., and Henry Houlden M.D., M.R.C.P., Ph.D., University of Thessaly, Greece and University College London, England

*Denotes second year of funding

32 | Our Researchers

Our Researchers Fellowship and Career Development Grants | $1.22 Million Prepare leaders in Parkinson’s research and clinical practice.

Research Fellowship Projects | $190,000 Development of a Progressive Neurodegenerative Mouse Model of Parkinson's Disease Ane Korff, Ph.D., St Jude Children's Research Hospital Evaluating Pedunculopontine Nucleus Stimulation as a Treatment for L-DOPA-Resistant Gait Disorders in Advanced Parkinson's Disease Abirami Muralidharan, Ph.D., University of Minnesota The Role of Parkin in Regulating Mitochondrial Dynamics and Homeostasis in Cortical and Dopaminergic Neurons Victor Van Laar, Ph.D., University of Pittsburgh The Locus Coeruleus as a Substrate for Parkinsonian Cognitive Inflexibility Elena Vazey, Ph.D., Medical University of South Carolina

Post Residency Fellowship Training | $720,000 Columbia University Medical Center Rush University Medical Center David Arkadir, M.D., Ph.D. Sheila Rane, M.D. Christopher W. Hess, M.D. Houman Homayoun, M.D. Sheng-Han Kuo, M.D., Ph.D. Alexander Shtilbans, M.D. Sirinan Tazen, M.D. Mary Ann Thenganatt, M.D. Tuhin Virmani, M.D., Ph.D.

Effectiveness of O4 in the Regulation of Toxicity Levels in Parkinson's Disease Models Anna Norton; mentors Erich Wanker, Ph.D., and Jan Bieschke, Ph.D., Charité Medical School of Humboldt University, Germany Role of Beta-Band Activity within the Internal Segment of the Globus Pallidus in Non-Human Primates During a Command/ Countermand Motor Task Shaun Patel; mentor Emad Eskandar, M.D., Massachusetts General Hospital In Vivo and In Vitro Assessment of Urate Modulation by Pyrazinamide Matthew Pearce; mentor Michael A. Schwarzschild, M.D., Ph.D., Massachusetts General Hospital GABAa Receptor Expression Profile and Function in the Globus Pallidus Ruth Quintana; mentor C. Savio Chan, Ph.D., Northwestern University, Chicago Effect of Forced Exercise on Resting State Functional Connectivity in Parkinson’s Disease Chintan Shah; mentor Michael D. Phillips, M.D., Cleveland Clinic Foundation

Summer Student Fellowship Projects | $45,000

Examination of PGC-1 and SIRT3 Pathways in LRRK2 and Alpha-Synuclein Models of Parkinson’s Disease Aarthi Subramanian; mentor M. Flint Beal, M.D., Weill Cornell Medical College

Identifying the Natural and Functional Progression of PD Rachel Boehm; mentor Quincy Almeida B.Sc., M.Sc., Ph.D., Wilfrid Laurier University, Canada

Potential Abnormalities of Brain Circuits of Parkinson’s Disease Lirong Tan; mentor Jing-Huei Lee, Ph.D., University of Cincinnati

R2* Changes in Substantia Nigra and Dentate Nucleus Related to Tremor-and Akinetic/Rigid-Predominant Parkinson’s Disease Christopher DiMaio; mentor Mechelle Lewis, Ph.D., Penn State College of Medicine

The Effect of Wii Fitness Training on Postural Imbalance in Patients with Parkinson’s Disease Megan Trager; mentor Helen Bronte Stewart, M.D., Stanford University

The Effects of Autophagy Enhancement on Alpha-Synuclein In Vivo Darius Ebrahimi-Fakhari; mentor Pamela J. McLean, Ph.D., Massachusetts General Hospital/Harvard Medical School

Collaborative Fellowships | $265,000

Instability in Persons with Parkinsonism: Assessment and Interventions in a Community Setting David Galaso; mentor Lee Dibble, P.T., Ph.D., A.T.C., University of Utah β oscillations in the STN and SNr of Parkinson’s Disease Patients Vahagn Karapetyan; mentor William D. Hutchison, Ph.D., University of Toronto Cardiovascular Autonomic Dysfunction as an Early Biomarker for Parkinson’s Disease Sung Kim; mentor Sheila Fleming, Ph.D., University of Cincinnati College of Medicine Cognitive Profiles of PD: Implications for Dementia Ivy Miller; mentor Alice Cronin-Golomb, Ph.D., Boston University

PDF-AANF Clinician-Scientist Development Award | $165,000 (three years) (co-sponsored with American Academy of Neurology Foundation) Mechanisms of Cell Type-Specific Vulnerability in Synucleinopathy: A Yeast-Stem Cell Dual Discovery Platform Vikram Khurana, M.D., Ph.D., Massachusetts General Hospital PDF-PSG Mentored Clinical Research Award | $100,000 (Funded by a grant from PDF to the Parkinson Study Group) Behavioral Treatment of Anxiety in Parkinson’s (BEHTA-PD): A Pilot Study Jessica Calleo, Ph.D.; mentors Laura Marsh, M.D., and Melinda Stanley, Ph.D., Baylor College of Medicine Genetic and Transcriptional Analysis of Susceptibility for PD Neuropathology Joshua Shulman, M.D., Ph.D.; mentors Philip De Jager, M.D., Ph.D., Lewis Sudarsky, M.D. and Clemens Scherzer, M.D., Harvard/Brigham and Women’s Hospital

The PDF Effect: Annual Report 2011 | 33

Statement of Financial Position

June 30 2011

2010

$779,578

$670,883

550,651

1,055,553

74,161

81,764

12,446,070

11,045,254

235,521

327,069

56,540

56,540

-

236,935

210,723

201,024

$14,353,244

$13,675,022

Accounts payable and accrued expenses

$766,321

$823,380

Grants payable

1,327,440

1,368,427

210,723

201,024

2,304,483

2,392,831

Unrestricted

8,608,353

9,547,208

Temporarily restricted

1,073,946

1,734,983

Permanently restricted

2,366,462

Assets Cash and cash equivalents Contributions and other receivables Other current assets Investments, at fair value Fixed assets, net Other noncurrent assets Life Estate Gift Investments — restricted as to use Total assets

Liabilities and net assets

Deferred compensation plan Total liabilities Net assets

Total net assets Total liabilities and net assets

12,048,761

11,282,191

$14,353,244

$13,675,022

In 2011, PDF was awarded both a four-star rating from Charity Navigator (the highest) and the Charity Seal of Approval from the Wise Giving Alliance of the Better Business Bureau (BBB).

34 | Financial Reports

Financial Reports

Statement of Activities

Year ended June 30, 2010

Year ended June 30, 2011 Unrestricted

Temporarily Permanently Restricted Restricted

Total

Unrestricted

Temporarily Restricted

Total

Operating support and revenue: Contributions

$ 4,022,882

$172,277

-

$4,195,159

$ 4,141,567

$610,493

$4,752,060

2,398,320

-

$2,366,462

4,764,782

3,761,136

-

3,761,136

Special events revenue, net

348,050

-

-

348,050

207,828

-

207,828

Investment income

976,398

-

-

976,398

805,386

-

805,386

Net assets released from restrictions

833,314

(833,314)

-

-

273,709

(273,709)

-

8,578,964

(661,037)

2,366,462

10,284,389

9,189,626

336,784

9,526,410

Research

5,671,135

-

-

5,671,135

5,626,735

-

5,626,735

Public information/patient information and referral services

1,990,591

-

-

1,990,591

2,071,164

-

2,071,164

7,661,726

7,697,899

586,536

574,680

-

Bequests

Total operating support and revenue

Operating expenses: Program services:

Total program services

7,661,726

7,697,899

Supporting services: Management and general

586,536

-

-

574,680

1,269,557

-

-

1,269,557

1,227,820

-

1,227,820

Total supporting services

1,856,093

-

-

1,856,093

1,802,500

-

1,802,500

Total operating expenses

9,517,819

-

-

9,517,819

9,500,399

-

9,500,399

2,366,462

Fundraising

Change in net assets

(938,855)

(661,037)

Net assets, beginning of year

9,547,208

1,734,983

$8,608,353

$1,073,946

Net assets, end of year

$2,366,462

766,570

(310,773)

336,784

26,011

11,282,191

9,857,981

1,398,199

11,256,180

$12,048,761

$9,547,208

$1,734,983

$11,282,191

Administration & Fundraising

20%

Percentage of our dollars spent on our programs and our mission

Advocacy

5%

Education

15%

HOW Our Funds Were Spent 2011 Research

80%

60%

The PDF Effect: Annual Report 2011 | 35

Our People

Board of Directors

Scientific Advisory Board

Officers

Constance Woodruff Atwell, Ph.D. M. Flint Beal, M.D. Robert Burke, M.D. Cynthia L. Comella, M.D., F.A.A.N. David Eidelberg, M.D. Stanley Fahn, M.D., Chair Christopher Goetz, M.D. Lloyd Greene, Ph.D. J. Timothy Greenamyre, M.D., Ph.D. Danna Jennings, M.D. Katie Kompoliti, M.D. Jeffrey H. Kordower, Ph.D. J. William Langston, M.D. Karen Marder, M.D., M.P.H. Serge Przedborski, M.D., Ph.D. Kathleen Shannon, M.D. Yaakov Stern, M.D. David Sulzer, Ph.D. G. Frederick Wooten, M.D. Anne B. Young, M.D., Ph.D.

Page Morton Black Chairman Lewis P. Rowland, M.D. President Timothy A. Pedley, M.D. Vice President Stephen Ackerman Treasurer Isobel Robins Konecky Secretary Stanley Fahn, M.D. Scientific Director

Directors Constance Woodruff Atwell, Ph.D. Karen Elizabeth Burke, M.D., Ph.D. Margo Catsimatidis Barbara Costikyan Peter Dorn George Pennington Egbert III David J. Eger, Ph.D. Stephen B. Flood, Esq. Sarah Belk Gambrell Stephanie Goldman-Pittel Arlene Levine Marshall Loeb Howard DeWitt Morgan Marie D. Schwartz Domna Stanton, Ph.D. Sandra Feagan Stern, Ed.D. Melvin S. Taub Martin Tuchman

Executive Director Robin Anthony Elliott

People with Parkinson's Advisory Council Maria De Leon, M.D. Steve DeWitte Hao Dong, Ph.D. David J. Eger, Ph.D.*, Co-Chair Eric Hellinger Rhona B. Johnson* Daniel J.B. Kiefer, J.D.* Linda M. Morgan, M.B.A., R.Ph. Michael O’Leary* Tom Palizzi Marc Sherman, J.D. Ann Wasson*, Co-Chair Peggy Willocks Fred Woodlief, D.D.S. * founding members

36 | Our People

Image Credits: Page 2 Ben Hide Photography (top); Page 4 Janet Charles (top); Page 4 Modified from Ebrahimi-Fakhari et al., The Journal of Neuroscience; Page 5 Courtesy of Lorenz Studer, M.D.; Page 6 Modified from Vilariño-Güell at al., American Journal of Human Genetics; Page 7 Modified from Shannon et al., Movement Disorders; Page 10 Janet Charles; Page 13 Lars Howlett, The Half Moon Bay Review (top); Page 16 Janet Charles (top); Page 17 Patrick McMullan (B); Patrick McMullan (C); Janet Charles (G); Patrick McMullan (K); Cynthia Servais (N)

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