BioMatters - Spring 2009

BioMatters SPRING 2009

A MichBio Publication Showcasing Michigan’s Biosciences Industry

Innovation, Technology and Commercialization Michigan Incubators Boost State’s Bioscience Entrepreneurs

In This Issue: 2009 Michigan Biosciences Directory and Resource Guide Also Featured: Michigan Universities Pack a Powerful R&D Punch Governments Building Foundations for Regional Bioscience Growth

IN MICHIGAN, SOMETHING NEW IN HIGH-TECH INNOVATION IS HAPPENING EVERY DAY. Working with our partners at MichBio, the Michigan Economic Development Corporation can connect high-tech companies and entrepreneurs to services, incentives, networking opportunities and venture capital through resources like the 21st Century Jobs Fund to help them grow and prosper.

SM

Visit MichiganAdvantage.org and learn how Michigan can give your biotech company the Upper Hand.Â

MichiganAdvantage.org

GOVERNOR’S MESSAGE

Dear Innovator,

Whether you are looking to launch a new company, expand, or relocate operations, I encourage you to consider the

advantages Michigan has to offer. With an abundance of high-tech talent, a legacy of technical know-how, proximity to 21st century infrastructure, and strong state and local support, Michigan is the perfect place to take your life science enterprise to the next level.

The bioscience sector is a pillar of Michigan’s economic diversification strategy. Together, our public and private invest-

ments in life science research and development and our strong partnerships with educational institutions, entrepreneurs, and commercial businesses position Michigan well as a world-class center of life science research and product development.

Over the past decade, Michigan has earned a well-deserved reputation for leadership in bioscience innovation. We have

made investments totaling more than a half billion dollars to support initiatives such as the Life Science and Technology tricorridors, the 21st Century Jobs Fund, the Venture Michigan Fund, and the Bioscience Research and Commercialization Center. And we are the #2 state in the nation for overall industrial research and one of the fastest growing life science states with more than 125 new companies since 2000 and more than 540 life sciences companies overall.

Our aggressive strategy to grow and diversify Michigan’s economy, along with commercialization activities, healthy

sources of venture capital, and other growth opportunities created by our targeted initiatives, assure that Michigan will continue to be an important life sciences center well into the future.

Sincerely,

Jennifer Granholm Governor of Michigan

Your Complete Biosciences Package That’s the Michigan “Upper Hand” advantage Wherever you are in the world, wherever you are in the R&D process, Michigan bioscience companies and organizations have the expertise, technologies and development understanding to give you the “Upper Hand” advantage.

Join us in the Michigan Pavilion #3147 Hosted by:

with Michigan exhibitors: Ann Arbor SPARK • Ash Stevens Beaumont BioBank • Genetics Squared LLC Jasper Clinical R&D • Kalexsyn, Inc. MSU Technologies • Oakland County’s Medical Main St. Southwest Michigan First • The Right Place TSRL, Inc. • University of Michigan Technology Transfer Van Andel Institute • Velesco Pharmaceutical Services Wayne County • Wayne State University • zuSyn, Inc.

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BioMatters | Spring 2009

We know people.

Nurturing an idea into a marketable product and growing it into a dynamic, self-sustaining bioscience company is a process.

How do Michigan companies connect with the right people, learn what they need to know, find the resources to keep the pipeline flowing?

MichBio brings the total continuum together. We know the players, the market; and what it takes to succeed.

We give you access to a valuable network of people representing all facets of the biosciences community.

We are your matchmaker, your guru and your standard bearer.

In a state boasting the world’s longest freshwater coastline, with oceans of lakes, where water is a way of life and life is good; in an industry that studies life at its core, MichBio is there to propel Michigan’s bioscience people, products and prospects.

Join us.

BioMatters | Spring 2009

Ann Arbor, MichigAn

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734.527.9150

www.Michbio.org

PRESIDENT’S MESSAGE

Welcome to Michigan’s Biosciences Community!

In this its second issue, BioMatters continues an up-front, inside look at

P R O F E S S I O N A L S TA F F

Stephen T. Rapundalo President and CEO

Michigan’s biosciences community today and the many exciting discoveries that

srapundalo@michbio.org

may lie ahead for tomorrow.

734.527.9144

The biosciences are “big” business in the state and account for almost 96,000

direct and indirect jobs. Private bioscience R&D and academic research in Michigan

Stephen Field

contributes $9.34 billion to the state’s GRP, including $2.5 billion in direct private

Director,

payroll. Michigan has an enviable bioscience infrastructure with an advantageous

Operations and Controller

business environment, strong commercialization resources and incentive programs,

steve@michbio.org

an expert talent pool, and an exceptional quality of life.

734.527.9145

The state is home to a myriad of bioscience companies involved in R&D,

manufacturing, and contract research/support services — “a complete package

Jayne Berkaw

for R&D”. Michigan has it all — from drugs and therapeutics, medical devices and

Director,

equipment, diagnostics and research tools, information technology systems and

Marketing and Communications

software, clinical research and medical testing, as well as industrial biotechnology,

jayne@michbio.org

bio-agriculture, bio-defense, and bio-environmental. We are proud of our accomplish-

734.527.9147

ments and growth, and are working hard to nurture today’s and tomorrow’s ventures, and eager to give your business the “Upper Hand” Advantage.

The Michigan Biosciences Industry Association or MichBio, is a statewide,

non-profit trade group devoted to promoting the growth of the bioscience industry in Michigan. Our goal is to network the academic, industry and government participants into a cohesive whole and to provide various resources, matchmaking to

Heather Kusiak Administrative Specialist heather@michbio.org 734.527.9150

service providers, and purchasing programs to support companies and affiliates in our biosciences industry. We provide a forum for members to get to know each other and connect the many bioscience companies operating today in Michigan. We coordinate information among the many agencies and organizations interested in the biosciences sector. MichBio also represents the interests of the bioscience industry in Michigan before federal, state and local legislators and regulators. For whatever your needs in the biosciences — we’re here to help you get started, grow and succeed.

MichBio looks forward to meeting you at BIO 2009. Come see what Michigan’s

biosciences are all about — visit with us at the Michigan Pavilion (Booth #3147).

C O N TA C T I N F O R M AT I O N Physical Address 3520 Green Court, Suite 450 Ann Arbor, Michigan 48105-1579 Mailing Address P.O. Box 130199 Ann Arbor, Michigan 48113-0199 Phone

Stephen Rapundalo, Ph.D.

734.527.9150

President and CEO, MichBio

Fax 734.302.4933 Website www.michbio.org

BioMatters Next Issue: FALL 2009 Featuring l Informatics: Where Technology Meets the Challenges of Science l Michigan Leading in High-Growth Generics Industry l And more stories chronicaling news, trends and issues affecting Michigan’s biosciences industry

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General Information info@michbio.org

BioMatters | Spring 2009

C O R P O R AT E S P O N S O R S

P L AT I N U M

GOLD

O F F I C E R S , D I R E C TO R S A N D C O M M I T T E E S

Executive Officers Chairman Michael Kurek, Ph.D. Biotechnology Business Consultants Partner/President Vice Chairman Stephen Munk, Ph.D. Ash Stevens, President and CEO President and CEO Stephen T. Rapundalo, Ph.D. MichBio, President and CEO Secretary Christina DeHayes Asterand, Inc., General Counsel

S I LV E R

Treasurer Matthew L. McColl Ernst & Young LLP, Partner ssistant Treasurer A Ryan Noel Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Administrator

Directors Dan Calvo Assay Designs, Inc., President and CEO

BRONZE

Linda Chamberlain, Ph.D. West Michigan Science and Technology Initiative Executive Director

MEDIA

PATRON

Ash Stevens, Lumigen

FRIEND

Advantage Capital, Wayne State University

SUPPORTER

Biotechnology Business Consultants, Caraco, sanofi-aventis U.S., West Michigan Science & Technology Initiative

BioMatters | Spring 2009

Teri Grieb U of M Medical School, Office of Research Director of Administration for Research Office of Research and Graduate Studies Mark Kielb Altarum Institute Chief Financial Officer Barry Kline GlaxoSmithKline Director, Market Development Michael Kurek, Ph.D. Biotechnology Business Consultants Partner/President Paul Morris Consultant Stephen Munk, Ph.D. Ash Stevens, President and CEO Stephen T. Rapundalo, Ph.D. MichBio, President and CEO John J.H. Schwarz, M.D. Family Health Center Physician, Former U.S. Representative Eric Stief Wayne State University — Technology Commercialization Licensing Manager Director of Venture Development

David Felten, M.D., Ph.D. Beaumont Hospitals, Research Institute Vice President, Research and Medical Director

Karen Studer-Rabeler Coy Manufacturing/ Coy Laboratory Products General Manager Vice President, Business Development

J. Patrick Elliot Terumo Cardiovascular Systems Corp.

Vice President, Business Development

David Zimmermann Kalexsyn, Inc. Chief Executive Officer

James Freeman, Ph.D. Pfizer Animal Health Vice President, Laboratory Sciences

Committees

Ricardo (Richard) Fuentes Jr. Dow Corporate Venture Capital Global Life Science Investment Director

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Facilities Intellectual Properties and Legislation Marketing and Communications Membership and Services Programs Public Policy

OAKLAND UNIVERSITY INNOVATION OPPORTUNITY Where

and

Meet

APPLIED RESEARCH Oakland is a known leader in many applied research disciplines including biomedical research, manufacturing, information technology, alternative energy/power train and homeland defense.To foster emerging discoveries, the university features several noted research centers, including:

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Fastening and Joining Research Institute Automotive Antenna Measurement Instrumentation Lab Center for Robotics and Advanced Automation Eye Research Institute Center for Biomedical Research OU’s SmartZone Business Incubator (OU INC)

Office of Grants, Contracts and Sponsored Research 544 O’Dowd Hall 2200 North Squirrel Road Rochester, MI 48309-4401 research@oakland.edu www.oakland.edu/research

For further information, contact: T.C.Yih,Vice Provost for Research • (248) 370-2552 AAF-2775 3.09

We Know Biotechnology and Life Sciences Attorneys and Government Policy Advisors in our Biotechnology and Life Sciences Team provide customized, multi-disciplined and collaborative services and formulate legislative strategies for biotechnology and life sciences clients. Our clients range from start-ups to public companies to nonprofits in a variety of industry sectors including pharmaceuticals, health care services, biotechnology, medical devices and equipment, and computer technology and software applicable to the biotechnology and life sciences industry. For further information or to make an appointment with one of our Attorneys or Government Policy Advisors please contact: Jin-Kyu Koh at (313) 568-6627 or jkoh@dykema.com or Theresa Carroll at (734) 214-7698 or tgcarroll@dykema.com.

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BioMatters TA B L E O F C O N T E N T S

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MichBio Corporate Sponsors, Officers, Directors and Committees

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Students Collaborate to Give the Gift of Life

Feature Story: Michigan Incubators Hatch Bioscience Innovators

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Southwest Michigan Innovation Center a Leader

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RESEARCH: Michigan Universities Pack a Powerful R&D Punch

21

Williamston Inventor Takes Aim at Airway Obstructions

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ECONOMIC

DEVELOPMENT:

Governments Building Foundations for Regional Bioscience Growth

34

38

Michigan Proposal 2 Passage Resurrects Embryonic Stem Cell Research in the State

Open Source Approach Opens Markets for Ann Arbor SPARK MEDC Shepherds State’s Biosciences

35

TECHNOLOGY: State Expects to be Sitting on Top

41

Scientist Finds Insecticide Weapon Inside Spider Mouths

44

NEW FRONTIERS: Pint-Sized Nanomedicine Industry

49

Guest Opinion: Balancing Life Science Efforts For Sustainable ROI

DIRECTORY & RESOURCE GUIDE

50

Feature stories and sidebars by Steve Raphael.

The following MichBio members are featured in this issue of BioMatters: Accuri Cytometers, Ann Arbor SPARK, Asterand, Inc., Beaumont Hospitals, Center for Applied Research & Technology, Central Michigan University Research Corporation Delphi Medical Systems, Dow Pharma, Esperion Therapeutics, Inc., Henry Ford Health System, Honigman Miller Schwartz and Cohn LLP, Housey Pharmaceutical Research Laboratories, LLC, Johnson & Johnson Co., Kalexsyn, Inc., Kellogg Co., Michigan Economic Development Corporation, Michigan State University, NanoBio Corp., NanoMed Pharmaceuticals, Inc., Oakland County Planning and Economic Development, Oakland University, Pfizer, PharmOptima, LLC, Proteos, Inc., Southwest Michigan First, Southwest Michigan Innovation Center, TechTown, Tech Initiatives Inc., The Right Place, Inc., University of Michigan Life Science Institute, Venomix, Inc., Wayne State University, West Michigan Science & Technology Initiative

Subscribe to BioMatters:

Visit www.michbio.org and click “Subscribe” or call 734.527.9150.

ADVERTISERS Ann Arbor Region CRO Network.........................9 Ash Stevens........................................................43 Asterand.............................................................42 Bank of Ann Arbor.............................................17 Beaumont Hospitals...........................................37 Biotechnology Industry Organization (BIO).........28 The Brooks Industrial & Research Park.............18 Business Review.................................................33 CMU Research Corporation...............................46 Cutting Edge Histology......................................23 DBA Analytical...................................................17 Doeren Mayhew.................................................36 Dykema................................................................6 Great Lakes Entrepreneur’s Quest......................40 Hylant Group......................................................18 Karmanos Institute............................................46 Lake Superior State University...........................43

Lumigen.............................................................26 MichBio................................................................2 Michigan Economic Development Corporation................................................. IFC Michigan Small Business Technology Development Center......................................42 Midwest Cleanroom Associates.........................46 MPI Research.....................................................14 Oakland County Planning and Economic Development..............................................OBC Oakland University..............................................5 P&M Corporate Finance, LLC .........................IBC Pfizer..................................................................11 Pharmacision.....................................................18 PhRMA...............................................................29 Pinnacle Insurance.............................................42 Prima Communications.....................................47

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ProPharma Group..............................................43 Quest Research Institute....................................22 Rader, Fishman & Grauer PLLC.........................46 RS Electronics....................................................23 Smith Haughey Rice & Roegge...........................26 Steve Raphael.....................................................47 Switchback.........................................................10 TransPharm Preclinical Solutions......................23 Twin Bay Medical...............................................47 University of MichiganTech Transfer.................29 University of Michigan Department of Biomedical Engineering...........................26 Varnum Riddering Schmidt Howlett.................17 Warner Norcross and Judd.................................37 Wayne County....................................................48 Wayne State University.......................................23 West Michigan Science & Technology Initiative.....40

BioMatters | Spring 2009

Bioscience is

“Big Business” in Michigan

That was the conclusion

of a recent study released by industry advocate, the Pharmaceutical Research and Manufacturers of America (PhRMA), which concluded that “Michigan has the assets to support and grow bioscience, particularly in the presence of its major research universities.”

The study points out that university biosciences expenditures totaled $897 million in fiscal 2007 with industry payrolls reaching nearly $2.5 billion for the same period.

Michigan is home to more than 540 biosciences

enterprises from pharmaceutical and medical device companies to diagnostics, bio-agriculture and nutriceuticals. The state’s contract research industry alone has the depth to handle business from across the globe at any stage of development.

Michigan’s SmartZones™ fuel a robust pipeline

of Michigan biosciences companies. SmartZones™ are distinct geographical areas where technologybased businesses gain from collaborations between local universities, industry, research organizations, government agencies and other community resources. The business incubators (see Feature story p. 12) located within many SmartZones™ nurture entrepreneurism with wet lab services, SBIR and STTR assistance and access to business planning and funding sources. From the tip of the Upper Peninsula to the bustling Lower Peninsula, Michigan’s “Upper Hand” Advantage is its Complete Biosciences Package. Look no further.

The study points out that

897

bioscience expenditures totaled million

with industry payrolls reaching nearly BioMatters | Spring 2009

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$2.5 billion.

These days, access to viable, high quality CROs can mean the difference between success and failure in rapidly moving a pharmaceutical to market.

That’s why so many life science leaders are looking to Southeastern Michigan as a source for CRO support in every phase of product development.

Here, in the heart of Michigan’s Life Science Research Corridor, they’re finding a unique concentration of expertise and resources spanning the entire product development continuum.

Introducing the Ann Arbor Region CRO Network In this dynamic quadrant of the Great Lakes State you will find dozens of high-capability CROs specializing in pharmaceutical product development. The Ann Arbor region CROs have formed an alliance network with the following capabilities: n Experienced life science researchers and consultants n A full spectrum of CROs, many of them headed by former scientists and executives from Pfizer, Warner-Lambert, Upjohn, and other life science research giants n Accessible, affordable pharmaceutical product development n Demonstrated success with a diverse client-base from start-up to established companies in the US, Europe, Asia & Australia Why Michigan should be your source for life science product development n #2 state overall for R&D expenditures n #3-ranked university for R&D funding n Rated the 2nd most business-friendly state n 4th largest high-tech workplace in the nation n One of the fastest-growing life science states n More than $2 billion invested annually in life science research Sponsored by: AAPharmaSyn www.aapharmasyn.com Assay Designs www.assaydesigns.com Cutting Image Histology www.cuttingimagehistology.com DBA Analytical (An NSF International Company) www.dba-global.com/analytical GLP Quality Consulting www.glpqualityconsulting.com

Integrated Nonclinical Development Solutions www.inds-inc.com Kestrel Consultants www.kestrelconsultants.com NextGen Science www.nextgensciences.com TSRL, Inc. www.tsrlinc.com Velesco Pharmaceuticals Services www.velescopharma.com

F I N A N C I A L M AT T E R S

F E AT U R E S TO RY

Michigan Incubators Hatch Bioscience Innovators

BioMatters | Spring 2009

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From mid-town Detroit to downtown Grand Rapids and up north to the great outdoors of Houghton in the Upper Peninsula, innovation is emerging from Michigan business incubators.

Incubators bring together the knowledge and resources of local governments, nonprofits, industry and academia to propel Michigan’s economy into the 21st Century. They provide a wide range of scientific and business support services to help scientists and entrepreneurs translate their innovations and technologies into commercial products.

Services include financial planning, business consulting, laboratory and office space and access to capital. It’s a good approach because most of the promising innovations are created by scientists and entrepreneurs lacking two prime ingredients for success: business savvy and money.

“Most inventors do not know how to formulate a business plan, business model, etc.,” says Ken Van Der Wende, president and CEO of the Center for Applied Research & Technology (CART), which is located within Central Michigan University’s Research Corporation in Mt. Pleasant. “Almost all startups have a hard time thinking through and writing a good business plan. Virtually all have a particular challenge with the pro forma financials. All have funding challenges.”

CART and Mid-Michigan PulL Their Weight Dendritic Nanotechnologies Inc. (DNT) in Mt. Pleasant, a company with origins dating back to The Dow Chemical Co., is a huge CART success story. CART helped DNT secure funding, develop its intellectual property and catch the eye of Starpharma Holdings Ltd., a Melbourne, Australia company developing nanotechnology products for the pharmaceutical industry that acquired DNT in 2006.

Among other CART successes is Bauer BioMedical whose genetic diagnostics tech-

nologies make possible the precise detection of cancers and other disease conditions through the analysis of peripheral blood or body fluid specimens, all without the need for invasive biopsy or excision of the diseased tissues.

“Almost all startups have a hard time thinking through and writing a good business plan. Virtually all have a particular challenge with the pro forma financials. All have funding challenges.”

CART partners with other economic development organizations throughout the region, including Saginaw Valley State University and the MidMichigan Innovation Center. Together these organizations are developing a regional business incubator network to improve their collective efficiency and effectiveness.

Just to the east in Midland, the fouryear-old MidMichigan Innovation Center (MMIC) is making its presence felt too. Like the other incubators across the state MMIC

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provides a wealth of critical resources, valuable services, flexible facilities, and entrepreneurial training and education to help support business ventures.

Our “role is to not only help our tenants and virtual tenants by connecting them to resources they wouldn’t otherwise be aware of, but to inform and educate entrepreneurs in our region and neighboring communities,” says Brent Case, executive director.

MMIC is a satellite of the Central Michigan University Research Corporation SmartZone™ in Mt. Pleasant and provides services to all industrial sectors without targeting specific technologies.

MMIC “is an emerging economic engine for the region,” he adds.“It is home to 17 tenant companies, employing 130 people and generating more than $5 million in new payroll.”

MMIC operates a 112,000-square-foot business incubator with significant support from The Dow Chemical Co., foundations and area universities. MMIC was instrumental in starting Blue Water Angels and connected Midland-based Gantec Advance LLC to multiple resources, including investment/funding, marketing and public relations, website development and office and lab space. Gantec manufactures and sells all natural products in the Blossom Springs Growing System, including a plant health supplement spray concentrate that eliminates the need for synthetic additives or sprays in potting soils.

BioMatters | Spring 2009

F E AT U R E S TO RY

West Michigan Roadmap Guiding Commercialization The West Michigan Science & Technology Initiative (WSMTI) in Grand Rapids works very closely with early stage inventors and entrepreneurs, generally for pre-A round funding to build a “commercialization” roadmap, says Linda Chamberlain, Ph.D., WMSTI executive director. It operates a high-tech incubator, chartered primarily for biosciences companies.

Like other incubators, WMSTI’s relationship with a nearby university, in this case Grand Valley State, enables it to access and leverage all university resources for its entrepreneurs. Chamberlain says the university’s support “is critical for sustainability.”

“The path to market is littered with more obstacles than imagined. The costs are always higher, things take longer than expected, and the regulatory restraints can be challenging,” Chamberlain says. “Success requires tenacity,

Like other incubators, WMSTI’s relationship with a nearby university, in this case Grand Valley State, enables it to access and leverage all university resources for its entrepreneurs.

and you need to be absolutely passionate about what you are developing.”

WMSTI has many success stories. It helped procure a $66 million private equity investment last year for Avalon Laboratories, an international supplier of cardiopulmonary vascular cannulae. In early January, Avalon won approval from the FDA and its Canadian counterpart to market three catheter devices used in extracorporeal life support systems.

Last September, San Diego-based Sequenom acquired the Center for Molecular Medicine

(CMM) – a clinical diagnostics lab in Grand Rapids. Sequenom is fielding new genetic tests that can detect disorders in the first trimester of a pregnancy.

Prior to its acquisition, CMM had created seven jobs in 18 months. With its new owner 20 more jobs will be added by mid-year and 500 more over the next five years. Sequenom also announced collaboration with Spectrum Health and the Van Andel Research Institute.

MLSIC Blueprint for the Future The Michigan Life Science and Innovation Center (MLSIC) provides entrepreneurial support and incubator space in southeast Michigan. Commenting when the new site was announced last September, Roger Newton, founder, president and CEO of newly resurrected Esperion Therapeutics Inc. said, “There will be a collective synergy to having everyone together.”

Resourceful Direction for Drug Development MPI Research understands the complexities often associated with drug development decisions, and partners with Sponsors in finding innovative solutions to their development challenges.

The comprehensive services offered by MPI Research include: Drug Safety Evaluation • General Toxicology • Developmental/Reproductive Toxicology • Infusion Toxicology • Safety Pharmacology • Abuse Liability Resource Services • Clinical Pathology • Histopathology • Regulatory Submissions Publishing (eCTD) • Consulting Services (IND preparation and filing)

Corporate Headquarters 54943 North Main Street Mattawan, MI 49071-9399 USA +1.269.668.3336 www.mpiresearch.com

BioMatters | Spring 2009

Discovery Services • Experimental Therapeutics • Molecular Imaging • Immunology • ADME/Pharmacokinetics • Neurobehavioral Sciences • Experimental Surgery and Device Evaluation Bioanalytical/ Analytical Sciences

MPI Research is a global Contract Research Organization (CRO) that performs preclinical and select clinical studies for biotechnology, pharmaceutical, and medical device companies. The company partners with its Sponsors in moving their test candidates along the regulatory pathway, in an effort to bring better, safer medications and medical products to the world.

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Southwest Michigan Innovation Center a Leader Located in Northville Township, MLSIC is a collaboration between Ann Arbor SPARK, the economic development agency for the Ann Arbor area, the Michigan Economic Development Corporation (MEDC) and the Greater Wayne County Economic Development Corp. Esperion anchors the incubator, which has office and lab space to house eight to 10 small start ups at a time.

Ann Arbor-based Accuri Cytometers is a classic case of the steps a company follows toward success and how a center nurtures a company through the process. Accuri developed and is now marketing a bench-top flow cytometer and cell analysis device. It started with licensing intellectual property

“Success requires tenacity, and you need to be absolutely passionate about what you are developing.” from the University of Michigan, a business plan, grant funding that led to prototypes and the establishment of proof of concept, and market feasibility. Accuri has since raised more than $20 million from venture capital companies.

Detroit Incubator Flexing Its Muscles TechTown in mid-town Detroit is the progeny of Wayne State University, General Motors Corp., the Henry Ford Health System, the Kresge Foundation, the MEDC and the Greater Wayne County Economic Development Corp. The incubator was incorporated in 2000, and tissue bank start up, Asterand, was its first tenant.

Writing in his blog, Randal Charlton, Asterand founder and former CEO, said he had little money and even less knowledge about the field he was entering. “However, I did know I was getting into a business that would be global in scope almost immediately,” because friends convinced him that with the mapping of the human genome there would be a market for biological samples for the development of new drugs.

There are good financial

reasons for start-ups to locate in an incubator but it’s more than that, and the Southwest Michigan Innovation Center (SMIC) in Kalamazoo is a good example.

For one thing, Western

Michigan University’s (WMU) Bioscience Research and Commercialization Center is located in the SMIC and offers young incubator companies access to expensive Since opening in 2003, Kalamazoo’s Southwest Michigan Innovation Center has been home to more than two dozen start ups.

equipment they couldn’t afford to keep in their own inventory.

There are also tax breaks from

its location within a Michigan SmartZone™, the WMU Technology and Research Park.

Plus there’s subsidized rent and, in some instances, forgivable loans provided by Southwest Michigan First to help companies finish lab space. If that’s not enough, there is the office space, business services and networking that occur there.

This past March, the SMIC celebrated its fifth anniversary with the opening of an 11,000 square-foot expansion.

Since its doors opened, the SMIC has become home to over two dozen start-ups;

many begun by former Pfizer/Pharmacia/Upjohn employees. Most of the first companies that launched in 2003 were service-based companies, like Kalexsyn, a medical chemistry contract research firm, and PharmOptima, which provides drug discovery consulting and laboratory services. Both companies have graduated to their own facilities, as well as AureoGen Biosciences which is developing innovative cyclic peptide-based genetic drug engineering technologies. A fourth company, Proteos, a contract research organization focused on peptides, has become the facility’s anchor tenant.

Thirteen companies, employing more than 200 people are currently housed in the

SMIC. Some, including pharmaceutical and medical device companies, are now locating there from out-of-state. In June 2007, Venomix, a start-up that makes insecticide products from spider-venom peptides based on research done at the University of Connecticut, became a tenant (see story page 41).

Emiliem, an oncology drug development company, relocated its research and devel-

opment center from Emeryville, California in October 2007. And in the summer of 2008, Tolera Therapeutics called the SMIC home and is using research from the Cleveland Clinic to develop innovative drugs to help reduce rejection in organ recipients.

This past March, the SMIC celebrated its fifth anniversary with the opening of an

11,000 square-foot expansion that includes HVAC renovations, nine additional laboratories and a new multipurpose room with space for an additional 40 employees.

“Ours is a unique success story. The expansion highlights the foresight, generosity

and continuing support of our community to make a better place for Southwest Michigan,” said SMIC CEO, Rob DeWit.

The collaborative partnerships that make for a successful SMIC are happening

in communities throughout Michigan, making the state a rich resource for emerging biosciences companies.

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BioMatters | Spring 2009

F E AT U R E S TO RY

Michigan Small Business Incubators Incubation facilities providing office and wet lab space to technology companies:

Ann Arbor SPARK Ann Arbor annarborusa.org Center for Applied Research & Technology (CART) Mt. Pleasant cmurc.com Michigan Life Science and Innovation Center Northville Township annarborusa.org/start-ups/ spark-incubator/#mlsic Mid-Michigan Innovation Center Midland midmichiganinnovationcenter. org/web MTEC Houghton mtecsz.com

“Wayne State University gave us terrific, purpose-built laboratories and provided technical and other support on a consistent basis.”

“Wayne State University gave us terrific, purpose-built laboratories and provided technical and other support on a consistent basis,” he adds. At the same time, the State of Michigan provided funding for our research and subsidized our promotional efforts...

The result was that we added one new job a month for the first six years of our existence.”

The icing on the cake came in 2006 when Charlton took Asterand public. The company is traded on the London Stock Exchange and was its most successful stock last year.

Charlton has since re-channeled his tremendous energies to building TechTown, a nine-year-old incubator in a 12-block park that stimulates job growth and smallbusiness creation by developing companies in emerging high-technology industries, including advanced engineering, biosciences and alternative energy.

TechTown is host to 70 growing companies with more than 30 high-tech start-ups enrolling in its business accelerator programs.

Working Together Regardless of Region With all these centers and a finite number of scientists and entrepreneurs it’s surprising that the centers don’t trip over each other, looking for new business opportunities. We are “competitive with other states, but we do not compete with other Michigan centers,” says Christine Turner, executive director, business development, for Ann Arbor SPARK. “We work openly with all counties (and) cities to promote job growth in Michigan.”

“We work openly with all counties (and) cities to promote job growth in Michigan.”

Like the other incubators, Ann Arbor SPARK feels that its job is to help companies be successful. If it cannot provide a service or help, “we have many resources that we refer companies to,” Turner adds. “We spend a lot of time meeting and networking with many businesses in Michigan, exactly for the purpose of finding complimentary providers.”

OUInc. Rochester www4.oakland.edu Southwest Michigan Innovation Center Kalamazoo kazoosmic.com

Wet

labs within

Michigan’s

incubators enable start-up entrepreneurs to pursue their science.

funding, training, administrative support and other services help them pursue their business.

TechTown Detroit techtownwsu.org University Corporate Research Park Lansing ucrp.msu.edu West Michigan Science & Technology Initiative Grand Rapids wmsti.org

BioMatters | Spring 2009

16

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18

RESEARCH

The

combined experience, depth

and competence of

Michigan

academic institutions provide huge economic impetus for the state.

Michigan Universities

Pack a Powerful R&D Punch

According to National Science Foundation statistics, Michigan ranks fourth in the country in terms of R&D expenditures. In 2007, the University of Michigan (U-M), Michigan State University (MSU) and Wayne State University (WSU) received approximately $1.4 billion in total research dollars, according to the University Research

Corridor (URC), an alliance created by the three schools to advance their mutual interests. That amount tops total research dollars reaped by North Carolina’s Research Triangle.

Researchers at the three universities have made dazzling discoveries and awe-inspiring breakthroughs that are advancing human health. For example: l A Wayne State scientist developed the anti cancer, anti-viral drug, AZT. The drug failed as a cancer fighter but was found to be the first effective drug in the battle against AIDS.

l

l

U-M scientists lay claim to Flu Mist nasal spray, as well as the discovery of the gene for cystic fibrosis.

Michigan State scientists discovered for the first time that leptin, a hormone produced by fat cells, supports white blood cell production in the body, enhancing immune function.

19

According to the URC, from 2002 to 2005 U-M scientists received 353 patents, resulting in 43 start-up companies, generating $63.6 million in revenue. Michigan State has received 184 patents with 28 start ups and $105.6 million in revenue; and Wayne State has had 95 patents and eight start-up companies that have resulted in $22.9 million.

BioMatters | Spring 2009

R esearch

In 2007 alone, U-M had 329 disclosures, signed 91 licensing agreements and was issued 87 patents. Michigan State had 161 disclosures, 28 licensing agreements and 35 patents.Wayne State procured 16 licensing agreements, 45 disclosures and 22 patents.

A disclosure is the written notice of an invention to the tech transfer office.

Researchers at the three universities have made dazzling discoveries and awe-inspiring breakthroughs that are advancing human health.

U-M is the state’s – and one of the nation’s – leading research universities. In 2007-08 university research spending hit $875.8 million, an all-time high. The school consistently ranks among the nation’s top five research universities, based on the NSF’s R&D expenditure statistics.

MSU’s Vice President of Research Ian Gray, Ph.D., says in fiscal 2008 the school received $288 million in research support from six sources, of which $164.2 million, came from the federal government. WSU research expenditures in FY 2007 were $235.2 million, a six percent increase from $220.7 million in 2006, says Julie O’Connor,

BioMatters | Spring 2009

director of research communications.

There’s a good reason why the three state schools can attract significant funding.

“Our scientists and our universities (go) toe-to-toe with anyone,” says Phil Torrence, the managing partner of Honigman Miller Schwartz and Cohn’s Kalamazoo office.

Torrence specializes in venture capital and mergers. In his 10 years in the field he has worked closely with the biggies – Stanford, Harvard, Yale and MIT. The world of funding, research and commercialization are indispensable to one another; to some degree you can’t have one without the other.

In its simplest form, a scientist comes upon a promising drug discovery in the lab and then applies for a patent. Next it’s time to pursue money from the government, private investors and university. When the research arrives at a point where it is ready for commercialization the school’s tech transfer office steps in, providing all sorts of business support while hunting for private companies or equity companies to buy the product’s licensing rights.

The new owner could oversee clinical trials, further develop and take the drug to market. If the drug is a commercial success, some of the dollars find their way back to the university as licensing fees. These fees are then reinvested into the university’s research units.

Its location in mid-town Detroit has been a boom for Wayne State’s research endeavors.“Through our cross-campus collaborations and our alliances with other institutions such as Children’s Hospital of Michigan, the Henry Ford Health System, and our University Research Corridor, to name a few, Wayne State is actively

20

involved on many research fronts,” O’Connor says. The universities provide the opportunity, resources and time, but the scientists are the heroes.

Jerome Horwitz holds a Ph.D. in organic chemistry and was an investigator at Wayne State for nearly 40 years until he retired in 2005. In the 1960s, while in hot pursuit of cancer killing drugs, he discovered anti-viral AZT and two other AIDS drugs. The drugs failed as cancer fighters and years later the National Institutes of Health, working with a predecessor to GlaxoSmithKline, turned AZT into the AIDS drug.

At the time of his discovery Horwitz was working for the Michigan Cancer Foundation with a federal grant from the National Institutes of Health.

Simon Ng holds a Ph.D. in chemical engineering and is a chemical engineering professor in Wayne State’s College of Engineering. He is deeply involved in solving the mysteries of biodiesel fuel production, contemplating using a variety of low-cost feedstock for continuous biodiesel production. He is director of the National Biofuels Energy Laboratory located at TechTown in mid-town Detroit.

Robert Freedman holds a Ph.D. in psychiatry in Wayne State’s School of Medicine.

His discoveries include development of a sensor to pinpoint the frequency of difficultto-track hot flashes. The sensor is less than 2 inches in diameter, weighs about an ounce and can collect and send data on changes in skin moisture for up to a month. He also is studying whether use of an anti-depressant drug has an impact on hot flashes.

“Our scientists and our universities (go) toe-to-toe with anyone.”

University of Michigan scientists Ivan Maillard and Yi Zhang, M.D. are looking for ways to make bone marrow transplants safer and more widely available. Their approach, considered revolutionary, is unproven thus far, they admit. But that didn’t stop the Damon Runyon Cancer Research

R esearch

Williamston Inventor Takes Aim at Airway Obstructions Eureka! From that simple observation the idea of more flexible intubation equipment emerged.

“(Richard) was in Special Forces at the time and told me

about the problems with intubation on patients with spinal injuries and battlefield injuries,” John says. “If you could do a gentle intubation without moving the patient you wouldn’t have to worry about spinal injuries, or injuries associated with facial injuries.”

Schwartz now holds three patents and 11 are pending.

Later, while attending a conference in Washington, D.C., he

started jotting down ideas and figured out an intubation design.

John Schwartz, Ph.D.,

developed the innovative airway

The brothers worked on a design and did a lot of field

work until they perfected the configuration. Their first patent

RIFL

was issued in 2003.

You’d be surprised at the ideas you can come up with while

on vacation from work. In the case of brothers John and Rich-

Michigan State doesn’t own the patents but the university “has

Schwartz now holds three patents and 11 are pending.

ard Schwartz it was a new piece of equipment called the “Rigid

been extremely helpful to us,” he says. “They arranged for a

Intubating Fiber Optic Laryngoscope (RIFL),” or airway rifle.

variety of meetings with people they thought could benefit us

The RIFL enables the medical practitioner to insert an

and helped with the original business plan. Economic develop-

endotracheal tube with ease, even when facing unanticipated

ment organization, Ann Arbor SPARK gave us a $25,000 grant in

complications, with minimal trauma to the patient. The RIFL

the early days and an acting CEO.”

is compatible with most supraglottic devices and allows for

endotracheal tube placement with or without a conventional

Lansing, in Williamston, MI, and raised about

laryngoscope.

$1,750,000. The company won a 21st Century

Schwartz headquartered AI Medical Devices just outside

Jobs Fund grant of $400,000 from the Michigan Economic Development Corp., and an individual

The RIFL enables the medical practitioner to insert an endotracheal tube with ease, even when facing unanticipated complications, with minimal trauma to the patient.

invested $500,000 in the company. The company has seven Michigan employees.

AI Medical began marketing the RIFL two

years ago, and has sold the product, priced at $6,500 each, to 60 hospitals from

Florida to Alaska. Schwartz expects

The beauty of Schwartz’s RIFL, says emergency medicine

specialist Mark Gulow, M.D., is its ability to navigate very

the company to reach profitability next

small areas of the trachea. If you have a difficult airway, be-

year. Last October AI Medical intro-

cause the individual may have a small mouth or large tongue,

duced a second generation RIFL

there is little room to maneuver the big blade on a glide

with video that uses a camera

scope, the most common product on the market.

and an LCD monitor on the back

of the scope.

Gulow, who has never met Schwartz, says the RIFL is “like

a caulking gun, …you can squeeze it to find the vocal chords...

It snakes through the trachea, looking through the light, like in (the movie) Fantastic Voyage. You’re slinking around and ‘whoa,’ there are the vocal chords, and you can slide the tube in.”

John Schwartz, who holds a Ph.D. in fisheries and wildlife

and an undergraduate degree in engineering, recently retired from Michigan State University. He and his brother, Richard, the head of emergency medicine at the Medical School of Georgia in Augusta, were sailing in the British Virgin Islands in 2001, sipping pina coladas and bending the drinks’ straws.

21 21

BioMatters | Spring 2009

R EASNEUAFA R CCHT U R I N G M

Foundation in New York City from awarding the pair a $450,000 “Innovation Award” for young scientists. They were two of just four winners, selected from 198 applicants.

MSU’s Gray is reluctant to name names.

“We have many (scientists) who are nationally and internationally recognized and make major contributions to their fields, whether it is education, environmental sustainability, bioenergy, international medicine, evolutionary biology, high energy physics, and nuclear sciences,” he says.

Many of his stars work directly and collaboratively with scientists from U-M and Wayne State as the schools believe strongly that working together is in their best interests as well as those of Michigan.

The state’s other public universities aren’t shrinking violets. Central Michigan, Michigan Tech, Oakland University, Western Michigan and Grand Valley State are delivering advances throughout the whole spectrum

“We have many (scientists) who are nationally and internationally recognized and make major contributions to their fields...”

of biosciences: health care, medicine, nanoscience, bioengineering and biotechnology, including agriculture and energy.

And that’s just the universities. The Jay and Betty Van Andel Research Institute (VARI) in Grand Rapids and the Barbara Ann Karmanos Cancer Institute in Detroit are privately held academic research institutes highly regarded for their respective and robust scientific programs.

Most recently, VARI announced the appointment of Jeffrey Trent, Ph.D., as its new Director of Research. He was previously Scientific Director of the National

Human Genome Research Institute and on faculty at the UM’s Comprehensive Cancer Center. Dr. Trent will lead an expanding VARI faculty focused on understanding the genetics and molecular origins of cancer and other diseases in a strategic partnership with the Translational Genomic Research Institute (TGen) where he also serves as President and CSO. Karmanos is one of 40 NCI-designated comprehensive cancer centers in the U.S. It cares for more than 6,000 new patients annually and conducts more than 700 cancer-specific scientific programs and clinical trials, second only to the M.D. Anderson Cancer Center in Houston, TX. Without a doubt, Michigan’s academic research institutions generate innovation, new technologies and commercialization ventures, a huge economic force for the state and much of it focused on the biosciences.

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BioMatters | Spring 2009

With embryonic stem cell research back in the mix, U of M’s Center for Stem Cell Biology Director, Sean Morrison, Ph.D., is upbeat about Michigan’s ability to make significant breakthroughs in the area.

RESEARCH

Michigan Proposal 2 Passage Resurrects Embryonic

Stem Cell Research in the State

Michigan voters decided last fall to ease restrictions on

In 2001 President Bush, following Michigan’s lead, pro-

embryonic stem cell research. The vote was vindicated when

hibited government funding of embryonic stem cell research.

President Barack Obama signed an executive order expanding

Existing and limited stem cell lines were basically grandfa-

federal funding for embryonic stem cell research and dishing

thered in. Scientists with private support were able to work

out millions of dollars to the nation’s top universities delving

on embryonic stem cells while others headed overseas where

into the potential of stem cells.

there were no restrictions and a warm reception.

Michigan has been out of the embryonic stem cell business

for a decade, having been one of five states with strict restric-

Last fall 53 percent of state residents voted in favor of Proposal 2 to lift the ban on stem cell research that dates back to 1978.

tions in place. Now the prospects for new money can propel the state in the field.

“We are playing catch up…you can’t do it overnight;”

says Sean Morrison, Ph.D., research professor and director of the Center for Stem Cell Biology at the University of

Michigan’s Life Science Institute (LSI). “It takes time to

center of embryonic stem cell excellence. “It will take more

overcome the competition from other states. We aren’t

than changing the law,” Cibelli says. “We have to attract

coming from a standing start [though]. We were walking

capital to come here rather than to California, Massachusetts,

slowly when everyone was running.”

Connecticut and New Jersey. Cibelli says the impact of the

federal dollars is “good for researchers.”

Last fall 53 percent of state residents voted in favor of

Michigan faces some barriers in attempting to become a

Proposal 2 to lift the ban on stem cell research that dates back

to 1978. Proposal 2 allows the donation of embryos produced

“All we need to do is create a critical mass of scientists, then

in fertility clinics that would otherwise be discarded, and

the investment will trickle in.”

permits researchers to create embryonic stem cell cultures

to study disease.

the university, private donations and a smaller portion from

the federal government.

“It’s great that the people of Michigan were able to

The first step is getting the brain power here, he adds.

Michigan State’s stem cell research budget is funded by

remove this hurdle,” said Jose Cibelli, of Michigan State

University and holder of a Ph.D. in reproductive physiology.

Wayne County Stem Cell Commercialization Center, the first

Until the passage of Prop 2, Cibelli was working with stem cells

such center in Michigan, says Carol Brenner, a stem cell scien-

from monkeys and those approved by President Bush in 2001.

tist at Wayne who holds a Ph.D. in reproductive biology.

BioMatters | Spring 2009

24

The passage of Proposal 2 was a catalyst to establish the

The center is the brainchild of Wayne County

Executive Robert Ficano and is a partnership

Wayne State University and MSU will

Morrison believes scientists at U-M,

between Wayne County, Wayne State and Smart-

more than carry their weight in the

Zone™, TechTown. The 2,500-square-foot research

field. “It will take everybody to push

facility lab already has a two-year, $2.9 million

this field forward, and scientists at

financial commitment from Wayne County for

multiple institutions within the state are

laboratory construction, equipment and manage-

capable of making breakthroughs.”

ment, and $1.5 million from Wayne State. Wayne

The easing of restrictions on stem

cell research makes it possible for UM to develop its own new embryonic stem

The first step is getting the brain power here…“then the investment will trickle in”

cell lines to study, notably in the neurodegenerative diseases, such as Huntington’s disease.

Towards that goal, in mid-March

State has challenged TechTown to raise matching

the U-M announced the formation of the

funds. It also will serve as a site for academic

A. Alfred Taubman Medical Research

ventures.

Institute Consortium for Stem Cell Ther-

apies. The Consortium will be among

The center will allow Wayne State to trans-

late basic research into commercial products.

the first groups in the country to derive

new embryonic stem lines that are

“We are looking to collaborate with scientists

and research universities internationally,” says

linked to a database containing genetic

Randal Charlton, executive director of TechTown,

and medical history information about

who adds that the lab is in early-stage discussions

donor embryos and families. This should

with stem cell research teams in Sweden, Great

enable researchers to better understand

Britain and Hungary.

The lab is particularly valuable to small start-

Embryonic

stem cells provide a potentially renewable

source of replacement cells and tissues to treat diseases.

how disease genes have manifested themselves over generations. Before Obama lifted the ban, Michigan was one

up companies that rarely have the capital to afford the space and high-tech equipment that will be provided,

of six exploratory centers funded by the National Institutes of

Charlton adds.

Health to conduct embryonic stem cell research.

Brenner joined Wayne State nearly two years ago. Her lab has

Passage of Proposal 2 has already had a significant impact

focused on human embryonic stem cells and primate reproduction.

on recruiting embryonic stem cell scientists to U-M. “Hiring new

Thanks to Prop 2 passage “our lab is now expanding to…areas of

faculty members takes months when you’re searching for the

reproductive research using human embryonic stem cells that have

best people in the world,” Morrison says. The LSI started the

not been approved for NIH funding (previously).”

recruiting process last September in anticipation of Proposal 2’s

passage, and there are now plenty of resumes to choose from.

Brenner was at Louisiana State in New Orleans working in

a technology park when Hurricane Katrina ripped through the

city in 2005, essentially closing down Brenner’s lab. She worked

the university because of the embryonic stem cell ban.

For a long time it was rumored that Morrison could leave

with WSU’s Barry Bavister, best known for developing the first

“I stayed here because Michigan is a spectacular place to do

reliable procedures for IVF in monkeys prior to being recruited

research,” he says. “I would hope to have my cake and eat

to Wayne State.

it, too. I hope to be able to develop this environment into all areas of stem cell research.”

“It will take everybody to push this field forward, and scientists at multiple institutions within the state are capable of making breakthroughs.”

Michigan shares this “can-do” attitude and is poised to

greatly expand its presence and impact in the field of stem cell research.

Today Brenner’s scientific team is collaborating with UCLA,

doctors and scientists in the neurology area and has set up the Primate Center in Puerto Rico to do monkey IVF. It is getting a NIH grant to start making monkey-induced pluripotent stem cells for clinical translational studies.

25 25

BioMatters | Spring 2009

Realizing the Promise of Tomorrow’s Leaders

When it comes to the life sciences business, many attorneys just miss the point.

A good business law firm can help you get your life sciences company up and running, and secure legal protection for your products and ideas. Smith Haughey is certainly one of these firms.

But we bring something more to our life sciences clients. As one of Michigan’s premier health law firms, we understand the practicalities of the healthcare marketplace – the players involved, the regulatory and reimbursement issues, and the unique challenges and requirements of various healthcare environments.

As a result, we can provide invaluable insight that will help position your product and business for maximum

Jonathan Song, PhD Prof. Shuichi Takayama’s Micro/Nano/Molecular Biotechnology Lab

success. And that really is the point, isn’t it? To learn more, visit our web site or call and ask for a member of our

The University of Michigan Department of Biomedical Engineering (BME) works closely with industry and business to help improve products and techniques. We also provide several opportunities for you to support and build relationships with talented BME students who will be future leaders in the field. Find out how you can:

Life Sciences Industry Team.

• Support our Design Program, sponsor a project, mentor students • Recruit BME students for internships and staff positions • Participate in our BME Career Fair and other events

LIFE SCIENCES ATTORNEYS

www.shrr.com 616-774-8000

For more information go to: www.bme.umich.edu/industry

BioMatters | Spring 2009

Ann Arbor

26

Grand Rapids

Traverse City

R E SR EE A SRECAHR C H

Students Collaborate to Give the Gift of Life

Developed

by students at

Michigan Tech University,

the

CPRMattress

deflates in

10

seconds so a patient can be resuscitated on a firm surface.

For the past four years 15 students at Michigan Tech

department, asking them to find out why CPR was

University in Houghton, MI, have been building a better

proving ineffective in hospitals and led to a large number

mousetrap to improve the quality of CPR administered

of deaths.

in hospitals.

rested with the quality of existing foam mattresses upon

Their majors are in engineering, technical communi-

The faculty and students found that the problem

cations, management, marketing and finance, and their

which medical personnel administered CPR to patients.

finished product is the CPRMattress, a foam mattress that

deflates quickly to provide a firm surface to make CPR

a patient lying on a foam mattress, the CPR provided 41

more effective. The firmer the surface the more efficient

percent of the compression needed to resuscitate the

the compression.

patient; when a CPR board was placed under the patient

The students found that when CPR is performed on

the efficiency increased to 53 percent. The idea behind

Mattress Compression Efficiency

the CPRMattress was born.

When the CPRMattress is activated a vacuum motor

removes the air in the upper half of the mattress, causing the foam mattress to compress into a rigid surface. The vacuum will cycle again to make sure the mattress retains its rigidity. When the mattress is no longer needed it can be re-inflated by pushing and holding the activation button for 2 seconds. The mattress returns to full comfort

compression efficiency percentage

level within one minute. This technology is adaptable to

The current generation of foam mattresses, most

virtually any foam-based mattress.

commonly used in hospitals, is activated by patient

pressure and uses air valves to diffuse the mattress.

and strategic clinical sourcing manager for the Detroit

Medical Center. DMC nurses have crash carts with boards

“We could be in the market as close as the end

“It’s a good concept,” says Luretta Pandya, an RN

of this year,” says Laurilee Kroll, an MTU student and

and defibrillators to administer CPR when a patient goes

director of finance and marketing for Tech Initiatives,

into cardiac arrest. “[With the CPRMattress], you press a

the S corporation created to sell the CPRMattress.

button and it deflates in 10 seconds so the patient can be

resuscitated on a firm surface. You don’t have to manipulate

The students are working with the help of MTU facul-

ty and the Houghton SmartZone™, one of 15 state-backed

the patient to the right position to improve compression.”

locations where technology-based firms, entrepreneurs

and researchers take advantage of commercialization

for medical surgical and critical care patient populations.

resources.

price from $500 to $700, while the CPRMattress will cost

Medical research studies over the past eight years

Pandya believes the CPRMattress would be beneficial Kroll says the standard hospital air mattress ranges in

have shown that the depth and rate of compressions

from $2,000 to $2,500.

being performed are not meeting the standards set forth

by the American Heart Association. Thus, in 2005 the

2007, the project was heading for the shelf because

Cardiopulmonary Division of Portage Health Hospital

further support was needed for commercialization, Kroll

in Hancock approached MTU’s biomedical engineering

says. Then the SmartZone™ stepped in. It incorporated

After the students finished their research in early

Tech Initiatives, made the students equity partners

27

BioMatters | Spring 2009

RESEARCH

and helped them apply for a patent in 2007.

In its first three years the project was funded

completely by grants totaling $150,000, coming from

“Each student has been given stock in the company

based on their input in the project,”

the state of Michigan and private

Kroll says. “We work for half payment

investors. “Our future plans are to

and half equity.”

get the mattress into clinical trials

The Houghton SmartZone™ is

and entertain offers for licensing

now talking to a number of local and

agreements with current medical

national medical equipment companies,

mattress manufacturers,” Kroll says.

including Stryker Corp. in Kalamazoo

Currently the CPRMattress is in

and medical bed manufacturer,

its final design phase and is about

Batesville, IN-based Hill-Rom about

to go through further testing by

a licensing agreement, Kroll says.

Underwriters Laboratories Inc.

Currently the CPRMattress is in its final design phase and is about to go through further testing by Underwriters Laboratries Inc.

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BioMatters | Spring 2009

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BioMatters | Spring 2009

EECCO ONNO OM MIICC DDEEVVEELLO OPPM MEENNTT

Governments Building Foundations for Regional Bioscience Growth

BioMatters | Spring 2009

30

Local governments are aggressively establishing biosciences enclaves, as they view the sector’s growth potential amid challenging economic times. Partnerships have been created, resources committed and incentives provided to lure biotech companies to their areas or to nurture new and exisiting companies.

Oakland County Sees Bright Future for Bio Jobs

Bioscience is Big Business in Wayne County

The future belongs to high tech, and Oakland County Planning and Economic Development knows that that’s where its future has to be.

In late 2004 the county created the Emerging Sectors Strategy, identifying 10 emerging industries ripe for nurturing.

Biosciences and health care were two of the 10 and today are the fastest growing sectors in Oakland County, says Irene Spanos, the county’s senior business development representative.

The county boasts 4,324 biosciences and medical-related facilities, including hospitals, nursing homes, pharmaceuticals, medical devices and medical office building clusters. Knowing a good idea when it sees it the county recently launched Oakland County Medical Main Street, an effort to brand Oakland County as a “medical tourism” destination.

“We want to brand southeast Michigan as a biosciences hub,” Spanos says. The county is projecting the sector will create 45,000 jobs by 2018. It employed about 10,500 people last year.

The county uses its existing trade missions as well as exhibiting at many technology conferences regionally and throughout North America, Europe and Asia, to hunt for new partnerships.

Oakland County already has an impressive line-up of biosciences companies.

Wayne County’s economic development unit has created partnerships, granted money and reached out to biosciences professionals, all aimed at growing biosciences’ presence in the area.

At the 2008 MichBio Expo last November, county executives huddled with Michigan’s biosciences professionals to learn first hand about the industry’s challenges and opportunities. This was one more county strategy to further hone its life sciences business attraction efforts, says Todd Fenton, executive manager of the Wayne County Land Bank Corp.

Last summer Wayne County, along with the Michigan Economic Development Corp.

(MEDC), Ann Arbor SPARK (see story 34), the Michigan Life Science and Innovation Center (MLSIC) and others opened what it considers to be a cutting edge wet lab incubator in Plymouth Twp. on property vacated

by Pfizer Inc. It scored a major coup when Roger Newton moved his second generation Esperion Therapeutics into a portion of the 57,518 square foot building.

In addition to its MLSIC collaboration, Wayne County has: l Created a partnership with TechTown in mid-town Detroit to create the Wayne County Stem Cell Commercialization Center. (See story page 24.)

An

expanding list of research facilities now reside in

Grand Rapids’ Medical Mile, $1 billion worth of investment

the quadrant known as where there has been

in recent years. It began with the founding of the

Van Andel Institute (above) by Jay and Betty Van Andel in 1996 and has since spread to include Grand Rapids Community College’s Calkins Science Center, Spectrum Health’s Butterworth Hospital complex, Grand Valley State University’s Cook-DeVos Center for Health Sciences, and the Michigan State University Secchia Center Medical School, among others.

Spanos rattled off numerous existing ones, such as Somanetics, Delphi Medical Systems, Housey Pharmaceuticals and Rockwell Medical Technologies. And that’s not counting Beaumont Hospitals, a research giant that is now flexing its muscles in commercialization through its Beaumont Commercialization Center.

“We want to brand southeast Michigan as a biosciences hub.”

None of the county’s goals would be possible without a world-class workforce.

Officials work closely with local school districts and area colleges/universities to ensure students are learning 21st century skills. Oakland Community College has a promising bioscience-focused curriculum.

31

BioMatters | Spring 2009

ECONOMIC DEVELOPMENT

l Announced a $750,000 construction grant to the TechTown business incubator. This grant will enable TechTown to build out 10,000 square feet of office and laboratory space on its third floor – enough for nine to 12 new tenants. l Made available a pool of $250,000 of grant money for start-up companies located in the MLSIC Plymouth Township building.

For all the activity, commitment and energy throughout the state, life sciences professionals know what Fenton knows, “Life science is not a panacea to cure all our woes; it is crucial because it’s high tech and attracts highly educated people. Even if it was something that we didn’t have to do we would still do it.”

Right Place is Right for Grand Rapids The Right Place Inc. in Grand Rapids has the right stuff for western Michigan. At 24

Officials work closely with local school districts and area colleges/universities to ensure students are learning 21st Century skills. Oakland Community College has a promising bioscience-focused curriculum. years old it is a leader in regional collaboration, luring new biosciences companies into western Michigan and bolstering existing ones through a myriad of overlapping relationships.

For example, The Right Place formed a partnership with the West Michigan Science & Technology Initiative (WMSTI) that, in turn collaborates with the Van Andel Research Institute, Grand Valley State University, the City of Grand Rapids and Grand Rapids Community College.

The partnership has recently expanded to include Spectrum Health, Saint Mary’s Health Care, Mary Free Bed Rehabilitation Hospital, the Grand Angels and Michigan State University College of Human Medicine.

BioMatters | Spring 2009

The relationships are complex, but The Right Place’s vision is simple: l Lead West Michigan business development efforts. l Identify and develop emerging growth opportunities. l Strengthen the global competitiveness and innovation of existing regional manufacturers.

Wayne County’s economic development unit has created partnerships, granted money and reached out to biosciences professionals, all aimed at growing biosciences’ presence in the area.

One of The Right Place’s biggest accomplishments was recruiting Sequenom Inc. to the region from San Diego in 2008. Sequenom provides genomic and genetic analysis solutions for the research and molecular diagnostic markets.

The Right Place played an “integral and critical role” in the process of creating the Medical Mile in downtown Grand Rapids, says Tim Mroz, senior director of communications. “We provided economic development support to the city as well as public and private developers.”

The Right Place and Kalamazoo neighbor, Southwest Michigan First, often work together. In 2007 the pair co-funded a

32

thorough study of the biosciences industry in West Michigan. From there they developed “A 2007 Study on ‘Regaining Global Prominence in the Life Sciences in Western Michigan.’” The study focused on biotech, medical devices and pharmaceuticals.

The results of this study and execution of the plan helped fuel the existing West Michigan’s Life Science corridor, Mroz says.

Southwest Michigan Puts Bioscience Growth First The mission of Southwest Michigan First (SWMF) “is to create jobs and wealth in the Kalamazoo region,” says Heather Smith, vice president. The nine year-old private, nonprofit organization has assisted more than 120 organizations with retention, expansion and recruitment projects. It has overseen 26 bioscience company start-ups and funded 10 companies through its venture fund. It created more than 5,000 jobs in 2008, according to its website.

One of SWMF’s best tools is the Southwest Michigan First Life Science Fund.

SWMF established the $50 million fund in 2005 as a limited partnership venture fund to invest in early-stage bioscience companies. Smith says the fund is believed to be the largest sum of community-based private capital ever to be raised and managed by an economic development organization.

The fund only invests in companies that already have a presence or are committed to establishing a presence in Southwest Michigan, Smith says, such as Redmond, Washington-based Micronics Inc. Micronics is setting up its headquarters and production, distribution and customer support operations in Kalamazoo for the medical devices it is developing to speed up genetic testing.

“We work with existing companies within our region to expand their opportunities,” Smith says.“For fund companies…we provide assis-tance in helping them find partnership opportunities, executive leadership and physical space.”

Working with The Right Place, SMF has “forged a strong networking base with the

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ECONOMIC DEVELOPMENT

OPEN SOURCE APPROACH OPENS MARKETS FOR ANN ARBOR SPARK

“Economic development in Michigan

should take a page from the playbook of the ever-evolving software industry. Its “open source” philosophy—the source code that drives development should be open and available to all—is a model that can propel Michigan’s Life Science industry success in growing, retaining, and attractMichael Finney (left)

is

President & CEO

of

Ann Arbor SPARK.

ing business,” says Michael A. Finney, Ann Arbor SPARK CEO.

Ann Arbor SPARK has taken steps to pilot this approach to economic development

by designing initiatives and committing resources that are meant to be openly available and shared statewide. These resources include business incubation, talent enhancement, pre-seed funding, and cross-region assistance with development projects.

There are several economic programs that are “open source” and currently

delivering jobs, talent and other resources to Michigan:

l Michigan’s SmartZone network has provided the infrastructure needed to attract,

retain and grow business.

l The Michigan Life Science and Innovation Center (MLSIC) is a state-of-the-art wet

lab incubator developed collaboratively with the Michigan Economic Development

Corp. (MEDC), Wayne County Economic Development, Esperance Family Foundation,

New Economy Initiative of Southeast Michigan and Ann Arbor SPARK’s Foundation

(also see story page 31).

l The Michigan Pre-Seed Fund Capital Fund, a collaborative effort among Michigan’s

SmartZone network, has provided nearly $5 million in funding to 30 emerging

technology businesses.

l The Michigan Innovation Equipment Depot, a partnership between Ann Arbor SPARK,

MichBio and Pfizer, and supported by the MEDC,has provided nearly $6 million in

high-value repurposed laboratory equipment and supplies to emerging life sciences

companies across the state.

l The Economic Development Coalition of Southeast Michigan (members include

southeast Michigan economic development organizations) is working with local,

state, and federal government to secure necessary funding to support activities

of the six business accelerators within Southeast Michigan.

With the decline in manufacturing and loss of Pfizer jobs in the Ann Arbor region,

talent initiatives have been a cornerstone of economic development efforts. Programs like Hot Shots, that connects employees and employers in a fun “happy hour” format,

Israeli life science market,” she says, to pursue partnerships with biosciences companies looking to locate in the United States.

To date, the two organizations have met with almost 60 companies and four incubators.

Lansing Area Gets Boost from LEAP In 2007 private sector leaders in Greater Lansing realized they needed better collaboration to strengthen the region’s economic development efforts. Thus emerged LEAP, a public-private partnership, providing companies in Ingham, Eaton, and Clinton counties with the tools they need to succeed.

Michigan State University is the key partner in the collaboration.

Biosciences in total remains “big business” in Michigan, accounting for nearly 100,000 direct and indirect jobs.

It generates $9.34 billion in economic impact.

LEAP has 36 investor partners who are a “who’s who” of the region and state, including the Sparrow Health System.

Biosciences in total remains “big business” in Michigan, accounting for nearly 100,000 direct and indirect jobs. It generates $9.34 billion in economic impact, according to a recent study commissioned

The study concludes that Michigan has abundant assets to support and grow the biosciences, particularly in the presence of its major research universities and associated initiatives throughout the state.

or Mingle & Match, a sort of “speed-dating” for start-ups and potential employees, have been highly effective in supporting the retention of talent in our region and placing high-value knowledge workers in growing companies.

A steady stream of entrepreneurs seeking ways to accelerate their business provides

impetus for regional economic development activities. Programs like Entrepreneur Boot Camp are foundational resources for new businesses; BioArbor, a monthly education and networking series, and the Annual Collaboration for Entrepreneurship showcase the entrepreneurial success needed to support Michigan’s new economy. Leveraging educational resources throughout the region is integral to economic development. Ann Arbor SPARK’s partnerships with the University of Michigan, Eastern Michigan University, Washtenaw Community College and the University Research Corridor have increased the success of technology transfer and kept valuable knowledgeable workers here in the community — creating, innovating and thriving.

BioMatters | Spring 2009

34

by the Washington, D.C.-based Pharmaceutical Research and Manufacturers of America and released by MichBio. The study concludes that Michigan has abundant assets to support and grow the biosciences, particularly in the presence of its major research universities and associated initiatives throughout the state.

ECONOMIC DEVELOPMENT

MEDC Shepherds State’s Biosciences The MEDC has created many programs to grow the industry, but what it all boils down to is relationship building and investment, says Kapila Viges, managing director of program administration for MEDC.

For example it partnered with economic development

a continuity of capital to fuel the economy and we need

organizations in Ann Arbor, Holland and Kalamazoo to

more than traditional banking sources,” she added.

retain Pfizer talent and assets through the Company For-

mation and Growth Fund. The MEDC channeled $12 million

Life Science Corridor Program, have disbursed $323

from Michigan’s 21st Century Jobs Fund to the three or-

million in the form of convertible loans to for-profit com-

ganizations that, in turn, determined which former Pfizer

panies and grants to non-profit organizations for applied

scientists would receive free or be able to buy equipment

and basic science, and commercialization.

Since 1999 the Jobs Fund, and its predecessor, the

to start their own companies. Scientists received small

Commercializing to Success

equipment at no cost, and leased larger lab equipment.

In the arena of partnership-building, MEDC also works

“with universities to pull products out of the lab” and with

MEDC offers MEGA tax incentives based on job creation and retention for all businesses.

the venture capital community “to leverage funding to support the emerging technology,” adds Viges. “We started SmartZones™ (see map page 10) that had business and sci-

ence resources, notably incubators and wet labs,” to provide

The 21st Century Jobs Fund is the state of Michigan and

MEDC’s marquis program. State money flows into the fund

scientists with the environment to grow their technology.

to support entrepreneurs creating biosciences companies

at every stage of development. Recipients also include

SmartZones™ “establish Local District Financing Authorities

strategic services partners that can help start ups apply

(LDFAs) where private companies pay taxes and the LDFA

for government grants and learn how to commercialize.

captures those taxes that come back to us,” says Fred

In November 2005 the state used the tobacco settle-

Einspahr, former president and CEO of the Southwest Michigan

ment money and created the 21st Century Jobs Fund which

Innovation Center (SMIC) in Kalamazoo. “Nonprofits in Smart-

“absolutely” fills the void left by the institutional investors,

Zones™ don’t pay personal property tax on their equipment.”

Cindy Douglas, vice president of technology development

for the MEDC told X-ology magazine in the fall. “We need

and retention for all businesses. The state also has a

35

The state created SmartZones™ with tax incentives.

MEDC offers MEGA tax incentives based on job creation

BioMatters | Spring 2009

ECONOMIC DEVELOPMENT

technology commercialization credit for all 21st Century Jobs

Fund competitors, as well as an angel fund tax incentive.

tions that invested a total of $24 million in Arboretum

Ventures, an Ann Arbor venture capital fund, which in

Last year these tax incentive plans paid off. “We had

In 2003-04, the MEDC was one of many organiza-

the busiest year we ever had in getting tax incentives,

turn invested an undisclosed sum in HealthMedia. Last

which means companies are expanding,” Viges says.

year Johnson & Johnson Co. bought HealthMedia, seeing

it as a perfect fit to its expanding health care platforms.

MEDC also invests in the 21st Century Investment Fund,

and Venture Michigan Fund, both part of the 21st Century

In the next few years the state and MEDC will invest a total of $200 million in equity markets in Michigan.

Jobs Fund. These are funds of funds, investing in venture capital funds that invest in Michigan companies.

Overall, since 1996 the state has invested more than

$45 million in venture funds that in turn funded biosciences companies. A total of $35 million of that amount has come

since 2006, a sign that the state is serious about a multilat-

MEDC knows a good investment when it sees one. In the

eral approach to supporting entrepreneurial ventures.

next few years the state and MEDC will invest a total of

Despite the state’s current economic woes, the

$200 million in equity markets in Michigan. The money

MEDC Commits $200 M to Equity Markets

will come from the state’s Venture Michigan Fund, as

well as the 21st Century Investment Fund. Douglas

Ann Arbor-based HealthMedia Inc., which designs web-

based software that helps people manage certain diseases,

expects that $75 million will be placed annually in the

behavioral problems or general wellness issues, is a good

21st Century Jobs Fund through fiscal 2015.

example of how state investment works.

MEDC is banking heavily on the future of biosciences

in Michigan.

BioMatters | Spring 2009

36

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BioMatters | Spring 2009

TECHNOLOGY

State Expects to be Sitting on Top of an Eco-Friendly World

Michigan has an abundance of raw materials necessary for a vibrant bioeconomy.

BioMatters | Spring 2009

38

Michigan scientists are racking up significant discoveries on the road to developing the bioeconomy, and Michigan State University, along with Midland-based Dow Chemical Co., among others, are leading the way. Three years ago university President Lou Anna Simon created the Office of Biobased Technologies (OBT) to propel school research and resources aimed at fostering connections with public and private sector initiatives designed to expand Michigan’s bioeconomic sector.

OBT’s mission is to identify, encourage and support research programs that will position the university as a worldwide standard-bearer for the bioeconomy. To that end it functions as a coordination and communication office, assisting scientists in obtaining grants and contracts and building bridges to other universities, companies, and governmental agencies.

OBT’s mission is to identify, encourage and support research programs that will position the university as a worldwide standard-bearer for the bioeconomy.

The terms “bioeconomy” and “biobased economy” describe a future where people rely heavily on biomass, the fuel of the future. Biomass is a renewable resource composed of plant material and municipal and livestock waste that can be converted into electricity, fuels and plastics, as well as the basic components of chemical processes.

“MSU conducts a broad range of basic and applied research to answer critical questions about the bioeconomy,” says Steve Pueppke, director of the OBT at MSU. In 2007 the Department of Energy awarded MSU and the University of Wisconsin $135 million over five years to create

MSU researchers Bruce Dale and Mariam Sticklen (above), have genetically engineered corn varieties

to

produce the enzymes needed to break down cellulose and hemicellulose into simple sugars that can be fermented into ethanol.

the Great Lakes Bioenergy Research Center (GLBRC). The GLBRC funds projects led by dozens of MSU faculty members.

The MSU discovery of a plant protein — trigalactosyldiacylglycerol 4, or TGD4 — last summer by Christoph Benning, Ph.D., a professor in the department of biochemistry and molecular biology, holds great commercial promise.

Benning identified TGD4 as a protein necessary for chloroplast development.

Chloroplasts, in plant cells, convert sunlight, carbon dioxide and water into sugars and oxygen for the plant during photosynthesis. Understanding how the protein works could allow scientists to create plants that would be tailored specifically to produce biofuels, possibly making the process more cost-effective.

Benning’s work was funded by the Energy Department and the National

39

Science Foundation to the tune of nearly $1 million over the course of three years.

Just below the Arctic Circle, Kris Berglund, MSU biochemical processing researcher, is collaborating with scientists at the Luleå University of Technology in Sweden on products and processes that may play a crucial role in furthering Michigan’s bioeconomy.

Berglund’s research has spawned enterprises in Michigan, Sweden and France, and

Berglund’s research has spawned enterprises in Michigan, Sweden and France, and raised tantalizing possibilities for diversified biorefineries that crank out bioproducts ranging from fuels to chemicals. raised tantalizing possibilities for diversified biorefineries that crank out bioproducts ranging from fuels to chemicals.

Working Bugs, LLC, an East Lansing-based company, and its Swedish counterpart, Working Bugs AB, were co-founded by Berglund.

The companies identify microbes that could be used in fermentation processes to make products from renewable resources, as well as intermediate chemicals that are then used to make other biobased products.

BioMatters | Spring 2009

TECHNOLOGY

Plant Genetics, Crop Protection Dominate Dow Research For more than a decade Dow Chemical Co., primarily through its subsidiary Dow AgroSciences, has been working in the field of plant genetics and sustainable processing technologies for crop protection, pest and vegetation management, seeds, traits, and agricultural biotechnology. Dow AgroSciences has a facility in Harbor Beach, MI that employs 90 people devoted to manufacturing spinosad and spinetoram that are active ingredients in several insecticides consisting of naturally derived substances created through a fermentation process.

The EPA presented Dow AgroSciences with its Presidential Green Chemistry Challenge Award in 2007 for developing spinetoram.

Michigan’s

plentiful natural resources could support

the growth of dedicated biomass crops.

The company has joint ventures strung out worldwide, as well as domestically. It has a joint venture with a Brazil company to manufacture polyethylene from sugar cane.

The resulting ethylene will create ethanol.

Working with the U.S. Department of Energy’s National Renewable Energy Laboratory, Dow is developing a process that could convert biomass to ethanol and other chemical building blocks.

Dow AgroSciences has developed and received federal regulatory approval for the world’s first plant-made vaccine, Concerta, which contains no animal components and offers important safety advantages over conventional vaccines.

Future goals include improving crops, enabling lower cost feed stocks; bio-based routes to replace existing molecules; create new molecules; and both biotech and thermochemical conversion technology.

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40

TECHNOLOGY

SCIENTIST FINDS INSECTICIDE WEAPON INSIDE SPIDER MOUTHS

So far Venomix has raised $6 million in the form of an R&D licensing

agreement with Chemtura Corp., a $3 billion chemical company in Middlebury, Conn.

Levi Littell Herbst & Co., an investment banking boutique in

Chicago, was a consultant to Southwest Michigan First and wrote an introductory letter for Venomix in anticipation of the company trying to raise $8 million in Series B funding. Venomix is now starting the fundraising process and hopes to close in the fourth quarter, McIntyre says.

In its letter, Levi Littell says insects are becoming increasingly

resistant to commonly used insecticides that also can be harmful to humans and animals. Levi Littell says Venomix has overcome those problems.

The pesticide industry has not developed or introduced “novel

agents” into the market place over the past three decades, the company says, adding that the global market for safe and effective insecticides is $15 billion annually. Target markets include agriculture, animal health, household insects and commercial pest control.

McIntyre says the $8 million will subsidize operational costs for

the continued development of company products, as well as building The “eek!”

factor of spiders is lost on

his commercial team. Venomix now employs eight people full time.

John McIntyre, Ph.D.,

for whom the insects are creating a web of success.

The company soon will file an EPA Registration to begin field trials

next year. Mosquitoes, caterpillars, beetles and flies will be the

unwitting targets in the trials.

Spiders are scary creatures, especially if you’re a fly or mosquito.

Those insects never have a chance against the venomous peptides

spiders emit to kill them. So if you’re looking for ways to kill insects

gan just at a point in time when the state, academia, business and

without harming humans and animals why not capture those same

industry began harnessing their resources to help fledgling biotech

toxins?

companies, such as Venomix. McIntyre appreciates his good fortune.

That’s precisely what John McIntyre, Ph.D., is doing in Kalama-

Perhaps it’s serendipity but McIntyre has wound up in Michi-

“Michigan certainly has made

zoo. McIntyre boasts an impressive 30-year career in agricultural

a very significant step forward

biotechnology, including operational experience in the development

building venture capital and

and commercialization of specialty agricultural products.

facilities to attract companies

to southwest Michigan. In my

President and CEO of Venomix Inc., and working within the

Southwest Michigan Innovation Center (SMIC), McIntyre is developing

experiences over the past 20

technology licensed from the University of Connecticut Research and

years or longer in touring

Development Corp. (UCRDC).

the world, the innova-

tion center is as good

“We think we are the leaders in the field in developing environ-

mentally compatible insecticides for this century,” he says.

as any as I ever seen,”

he says.

Following 10 years in senior management at Ecogen Inc., McIntyre

moved to Michigan in 1995 as president and CEO of Emerald BioAgriculture Corp., formerly Auxein, in Lansing.

An Oregon native, McIntyre says he’s “always looking for exciting

opportunities” and found one while doing an online search in 2005 when he came upon UCRDC information. He contacted UCRDC, he says, looking for someone “to get the ball rolling,” to create Venomix. “We found each other.”

Through networking McIntyre met Patrick Moran, managing

director of Southwest Michigan First Life Sciences Fund. The next

Venomix

is currently developing three spider-venom peptides and will

sell these products directly in selected agricultural markets.

step was falling under the wings of SMIC.

41 41

BioMatters | Spring 2009

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NEW FRONTIERS

Pint-Sized Nanomedicine Industry Producing

Mega-Sized Results

Quality, not quantity characterizes nanomedicine research in Michigan, says Dr. James Baker Jr., who has been a world-renowned catalyst for growth in the sector.

“Michigan is on the leading edge but in an unusual way,” says Baker, who is also director of the Michigan Nanotechnology Institute for Medicine and Biological Sciences, a multidisciplinary team of University of Michigan scientists collaborating on nanoscience in biology and medicine. “We certainly have a lot of forefront research going on right now. What we don’t have is the breadth of activity you find on either coast. Our overall activity may be less, but our quality is second to no one.”

An immunologist at the University of Michigan, Baker is the executive chair of

BioMatters | Spring 2009

NanoBio Corp. The nine-year-old company develops and commercializes topical pharmaceuticals to prevent and treat infectious diseases, such as herpes and acne, as well as mucosal vaccines for the flu and hepatitis B administered through the nose.

NanoBio Looks to Big Results NanoBio is in good shape, Baker says, pointing to “wonderful clinical data” in its topical cold sores lotion that is as good as any [existing] anti-viral oral drugs. “And all

44

you have to do is dab it on,” he says.

The company finished Phase II meetings in April and is anticipating starting the final pivotal trial Phase III within the next six months, Baker says. He hopes to have the product on the market by 2011. Baker thinks

Baker thinks that NanoBio’s lotion is so good it can dominate the market and be sold over the counter.

the lotion is so good it can dominate the market and be sold over the counter. “We may need a marketing partner, but not necessarily a drug company,” he adds.

For its vaccines NanoBio began Phase I clinical trials in April 2008. Commercialization of a vaccine can take a little longer because you have to follow up longer on patients as you’re looking for an immune response, Baker says.

Avidimer Developing Cancer Products Despite Hard Economy Avidimer Therapeutics in Ann Arbor and NanoMed Pharmaceuticals in Kalamazoo also are on the shortlist of outstanding nanomedicine companies operating in Michigan.

Avidimer’s polymer avidimers are designed to maximize damage to disease targets while minimizing collateral damage to healthy tissue and cells.

Five-year-old Avidimer focuses on therapeutics for cancer detection and treatment. Its polymer avidimers are designed to maximize damage to disease targets while minimizing collateral damage to healthy tissue and cells.

Currently its drug candidate is in the preclinical stage and needs from $3 million to $5 million to go into Phase I clinical trials.

NanoMed Sees a Solid Market for Products NanoMed Pharmaceuticals is a specialty pharmaceutical company dedicated to developing therapeutic products to treat cancer and other serious diseases. Its core technology, Nanotemplate Engineering, is used to formulate small molecules, peptides, proteins, plasmid DNA, and diagnostic agents. The company is applying its technology to reformulate FDA-approved drugs to make them more effective at treating tumors that are, or have become, resistant to chemotherapy.

Avidimers

are

“smart

drugs” designed to maximize damage

to disease targets while minimizing collateral damage to healthy tissue.

NanoMed, was founded in 2000 by scientists Russell Mumper and Michael Jay, inventors of its advanced drug delivery technologies. Both men hold Ph.D.s in pharmaceutical sciences from the University of Kentucky, which has licensed their inventions to NanoMed. The scientists met Stephen Benoit at a venture capital forum sponsored by economic development organization, Southwest Michigan First in 2001. Benoit was recruited from Connecticut to run a Kellogg Co. division. At the venture capital forum he liked what he heard and saw, and he agreed to become the company’s CEO. The company finished its first institutional funding in 2006, raising $3.3 million.

It hopes to complete a $20 million Series B financing by year’s end, Benoit says.

NanoMed intends to self-fund early clinical development and out-license products at Phase II or later. It plans to file an IND in the first half of 2010, with Phase I trials starting 60 to 90 days after that. The $20 million will cover the cost of the initial trials.

Benoit says he is unfazed about raising more money. “Oncology is an area that is still interesting from an investor perspective.”

Dendrimer Technology Pays Off with Acquisition Dendritic Nanotechnologies Inc. (DNT) was started in Mt. Pleasant in 2003, built on technology developed 30 years ago by Dow Chemical Co.’s Donald Tomalia, who holds

45

a Ph.D. in chemistry. Tomalia’s technology focused on the application of dendrimers to safely deliver anticancer drugs, create powerful MRI contrast agents, and help provide scientists innovative materials for creating new products in numerous markets.

Today DNT is a wholly owned subsidiary of Melbourne, Australia-based Starpharma Holdings Ltd. Starpharma, which purchased DNT in 2006, and develops dendrimer nanotechnology products for pharmaceutical applications. Ken Van Der Wende, president and CEO of the Center for Applied Research and Technology in Mt. Pleasant (see story on page XX), considers its purchase by a huge international drug company “a success story.”

Dendrimers

can be selected to either retain the drug

throughout its lifetime or allow it to disassociate from the dendrimer following delivery.

Tomalia, often referred to as the father of dendrimers, helped start Dendritech in Midland, as well as a dendrimer nanotechnology program at the University of Michigan medical school. Today he is director of the National Dendrimer & Nanotechnology Center at Central Michigan University.

DNT, with an investment from Starpharma, began by manufacturing and selling a wide variety of dendrimers to scientists. In 2005 Dow moved the dendrimers intellectual property portfolio into DNT for a stake in the growing nanotechnology company. That same year DNT announced a breakthrough technology called Priostar, a new family of dendrimers designed to greatly reduce the cost and manufacturing complexity associated with dendrimers.

With these and other exciting nanotechnologies coming out of Michigan laboratories, expect the state’s nanoworld to expand in coming months and years.

BioMatters | Spring 2009

Developing tomorrow’s technologies for cancer today The Barbara Ann Karmanos Cancer Institute, an NCI-designated comprehensive cancer center and the only hospital in Michigan solely dedicated to fighting cancer, is developing new technologies as part of its overall cancer research every day.

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• Chemistry / Biochemistry • Bioinformatics • Pharmaceuticals • Research, Diagnostic, and Therapeutic Tools

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Contact: info@raderfishman.com www.raderfishman.com • 248-594-0600 Bloomfield Hills, MI • Washington, D.C. Salt Lake City, UT • Tokyo BioMatters | Spring 2009

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BioMatters | Spring 2009

G uest O pinion

My Opinion

Balancing Life Science Efforts For Sustainable ROI By Linda Chamberlain, Ph.D. Today’s headlines are filled with various uses of the term “investment”. The assorted stimulus packages are investments in the future of our economic vitality. The re-training of workers is an investment in sustainable skills and our ability to compete, and on and on. Given the challenges ahead, the hypothesis of investment is one that we in the life sciences must take particularly seriously. Perhaps in no point in history has it been so critical for our community to deliver a return on the investments being made, and do so in a manner that is strategic and transparent.

It seems many have come to associate life science new product development with an “all-or-nothing” financial model – discoveries and commercialization efforts that either go multi-platinum or die slowly in a spiral of ever-shrinking grants and dilutive equity funding.

Of course, there are no sure things. But investing in life science can and should be done in a manner similar to a sound financial portfolio, i.e., balanced between short-, medium- and long-term investments across diverse markets. Michigan’s investments in life science can and should be made in a well planned fashion.

In West Michigan, the West Michigan Science & Technology Initiative (the Initiative), has developed an inclusive strategy built around strengths in life science research and clinical expertise, as well as legacy leadership in advanced manufacturing and human factors in design. We are mapping a combination of life science investments, from near- term medical device, to mid-term new diagnostic capabilities to long-term development of new therapeutics to treat and cure disease, working diligently to maintain the investment of regional assets, from capital to incubator space.

At the Initiative, we have a good start in implementing a balanced portfolio strategy. The Venture Center incubator residents reflect a diversified profile: Avalon Labs in medical device, Sequenom Center for Molecular Medicine in diagnostics, and ClinXus, Grand Valley State University, and Michigan State University, in research for new therapeutics. These organizations have drawn over $66M in equity investment, and are promising over 500 new jobs over the next five years.

In 2008, seeking more strategic emphasis on a shorter return, the Initiative led the formation of the West Michigan Medical Device Consortium to internationally promote existing regional capabilities and capacities, as well as to build new, profitable collaborations. As is the case when managing any portfolio, delivering a good return on life science investments is a blend of science and art. Success requires collaboration and communication among many organizations working together for a shared vision. The Initiative has built several platforms for strategic collaborative efforts, i.e., filling gaps in product development infrastructure, and we will continue to seek opportunities to build a comprehensive asset base from which strong, competitive life science endeavors can be launched.

These challenging economic times place more emphasis on coordinating our state-wide assets for strategic diversification. The time is now for leadership, planning and effective asset management. Our many shareholders deserve nothing less.

Linda Chamberlain, Ph.D., is executive director of the West Michigan Science & Technology Initiative, based at Grand Valley State University in Grand Rapids, Michigan.

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BioMatters | Spring 2009

BioMatters M AY 2 0 0 9

Michigan Biosciences 2009 DIRECTORY and RESOURCE GUIDE MichBio is pleased to provide the 2009 Michigan Biosciences Directory and Resource Guide, the most comprehensive listing of information on the state’s biosciences companies and organizations and the many resources they have at their disposal.

The full directory, which includes everything you see here plus company contacts, email, profiles, listings by sector and county as well as sections on Michigan’s business advantages, incentives, workforce training and more is available on CD. The CD can be purchased online at www.michbio.org for $40 including tax and shipping.

Please Note: Information contained in the 2009 Michigan Biosciences Directory and Resource Guide is as current as possible. MichBio is not responsible for any missing or incomplete data. All attempts were made to validate information submitted by companies and update existing data in MichBio’s archives.

Companies and organizations bear sole responsibility for their profiles.

Add Your Company or Make Corrections

If your bioscience company, related organization or institution is not listed in this directory, and you believe it should be OR if your listing requires corrections, please contact MichBio at info@michbio.org or (734) 527-9150.

BioMatters | Spring 2009

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Abundant Resources Help Ideas Become

Life-Changing Realities General Resources MichBio is the statewide association committed to building Michigan’s biosciences industry into a growth engine for a revitalized economy. Its members are biosciences companies, academic and research institutions, bioscience service providers, and related organizations. MichBio is dedicated to fostering their collective impact by connecting its members with the essential resources, including goods, services, educational and networking programs, legislative representation, and partners that facilitate success. www.michbio.org (734) 527-9150 BioConnections is a program for MichBio members matching talented life sciences professionals with fulfilling positions in the state through an online talent search mechanism. www.michbio.org/BioConnections (734) 527-9150 Great Lakes Entrepreneur’s Quest (GLEQ) helps Michigan entrepreneurs build highgrowth, new economy business ideas into successful ventures by linking them to a statewide network of resources, expert advice, education and capital. Twice a year, GLEQ hosts a statewide business plan competition with cash prizes, media exposure and business development services. www.gleq.org (734) 527-9151 Michigan Economic Development Corporation (MEDC) is the state’s one-stop resource for businesses seeking to grow in Michigan.

Created through cooperation between state and local governments, the MEDC works with local communities and businesses to retain and expand job opportunities and improve Michigan’s

overall business climate. It can link you with all the state has to offer and guide you to the wide array of economic development tools that make Michigan the best choice for your company. www.michiganadvantage.org (888) 522-0103

Small Business Association of Michigan helps Michigan small businesses succeed by promoting entrepreneurship, leveraging buying power and engaging in political advocacy. www.sbam.org (800) 362-5461

centers for excellence Michigan Innovation Equipment Depot facilitates growth of biosciences companies throughout Michigan with access to previously used laboratory equipment critical to product research, development and manufacturing. It is the result of the collaborative efforts of Pfizer, MichBio, Ann Arbor SPARK, Southwest Michigan First and other Michigan SmartZonesTM to accelerate the commercialization of biotechnologies. www.michbio.org (734) 527-9150 Michigan Small Business & Technology Development Center (SBTDC) provides counseling, training, research and advocacy for new ventures, existing small businesses and innovative technology companies. Headquartered at Grand Valley State University, the SBTDC supports 12 regional offices and over 30 satellite offices in the state through a cooperative agreement with the U.S. Small Business Administration. www.gvsu.edu/misbtdc (616) 331-7480 New Enterprise Forum links entrepreneurs with management expertise, joint venture partners, business services, capital, and other critical resources. www.newenterpriseforum.org (734) 665-4433

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Biosciences Research and Commercialization Center of Western Michigan University is a commercially focused and science driven translational research center that dedicates its pharmaceutical expertise and resources to the commercialization of promising bioscience discoveries and the growth of Michigan’s bio-science business sector. www.brcc.wmich.edu (269) 544-1072 Grand River Aseptic Pharmaceutical Packaging is a fully validated, FDA/cGMP facility associated with the VAI and Grand Valley State University (GVSU) and serves the bio/pharmaceutical industry by offering aseptic fill-finish, lyophilization, client-driven custom packaging services and cold product storage. www.grandriverapp.com (616) 644-0555 Michigan Animal Models Consortium (MAMC) provides services associated with the development, analysis and maintenance of mouse models of human disease. The consortium combines the technological, IP expertise and facility resources at the AAALAC-accredited Van Andel Institute (VAI). The MAMC provides efficient and cost-effective animal modeling services. www.ctaalliance.org/cta-cores/michigananimal-model-consortium (616) 234-5684

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

Michigan Antibody Technologies Center (MATC) consists of the Monoclonal Antibody Technology Core at the VAI and the Hybridoma Core at the University of Michigan (U-M). The MATC has extensive capabilities in the generation, characterization, scale-up and purification of mAbs and fragments. www.vai.org/Research/Labs/AntibodyTechnology.aspx (616) 234-5342 Michigan Biological Imaging Center (MBIC) provides comprehensive scientific/ technical imaging expertise including drug safety and efficacy data to pharmaceutical industry clients. homepages.wmich.edu/~eversole (269) 387-5640 Michigan Center for Biological Information (MCBI) provides advanced bioinformatics and computational resources for investigators and in the academic and industrial sectors. This includes access to bioinformatics tools, genomics and proteomics databases, supercomputing resources, bioinformatics training, and bioinformatics consulting. www.ctaalliance.org/MCBI (734) 615-5814 Michigan Center for Bioscience Commercialization (MCBC) is a contract research and development organization located at the BRCC. The MCBC provides scientific, medical and regulatory consultation to aid in the development and commercialization of pharmaceutical, diagnostic and medical device discoveries. www.brcc.wmich.edu (269) 544-1072 Michigan Center for Structural Biology (MCSB) is designed to provide state-of-theart instrumentation and support in the area of macro-molecular structure/function determination for drug discovery. This includes x-ray crystallography, NMR spectroscopy, EPR spectroscopy, single molecular spectroscopy, protein expression and production and

BioMatters | Spring 2009

macromolecular structure, synthesis and sequencing. The MCSB is partnered with and utilizes beamline resources at the Argonne National Labs. mcsb.bch.msu.edu (517) 355-0199 Michigan High-Throughput Screening Center (MHTSC) is a contract research facility providing services in assay development and optimization and high throughput screening. Staffed by pharmaceutical industry scientists with drug discovery and HTS experience, the MHTSC offers screening of a 100,000+ compound library for a broad range of therapeutic targets with the client retaining IP rights to compounds identified in the screenings. www.mhtsc.kvcc.edu (269) 353-1582 Michigan Proteome Consortium (MPC) provides proteome mapping (protein interaction maps, membrane protein analysis, posttranslational modifications), high-throughput yeast two-hybrid screening, and proteome informatics services to both academic and industry clients. www.proteomeconsortium.org (734) 763-3130 Wayne State University Applied Genomic Technologies (MCGT) provides oligonucleotide genechip microarrays, custom cDNA microarrays, and other genomic technology services on a fee-basis. State-of-theart equipment and a full suite of molecular genomic tools for processing and analysis means an integrated offering for gene expression profiling and HTS data mining. www.bioinformatics.wayne.edu/MCGT (313) 577-3555

Michigan-Based Funding Sources The 21st Century Jobs Fund represents a bold initiative to diversify Michigan’s economy and stimulate job creation in emerging technology sectors. After being introduced by the Governor in 2005, it re-

52

ceived broad, bi-partisan support in the state Legislature. Using tobacco settlement dollars, it has already invested $156 million in over 95 commercialization projects in the life sciences, advanced manufacturing, alternative energy, and homeland security/defense sectors through business plan competitions.

In addition, the 21st Century Jobs Investment Fund was deployed to invest $109 million in venture capital and private equity funds.

To date nearly $75 million has been invested and attracted significant fund management activity to Michigan, providing Michigan entrepreneurs access to more diverse capital. www.michiganadvantage.org/21 Michigan Initiative for Innovation and Entrepreneurship The Michigan Initiative for Innovation & Entrepreneurship (MIIE) builds on Michigan’s universities as economic assets by speeding the commercialization of university research while promoting a culture of entrepreneurial risk-taking. The initiative partners Michigan’s philanthropic resources with university and private business resources to help launch new startup companies, and strengthen ties between small business, industry and academia. www.pcsum.org/miie.html (734) 647-5730 Michigan Pre-Seed Capital Fund supports high-tech start-up companies as they near commercial viability by providing access to early-stage capital to accelerate company development. These funds extend the personal investment of entrepreneurs during the critical stage when they are developing their businesses to the point of readiness for outside investment. Information is available from local SmartZonesTM or www.AnnArborUSA.org Venture Michigan Fund is a $95 million venture capital investment program formed under the Michigan Early Stage Venture Investment Act of 2003 to promote Michigan’s economic health by assisting in the creation of jobs, new businesses and new industries

D I R E C TO RY & R E S O U R C E G U I D E

within the state. The VMF makes investments ONLY in venture firms that invest primarily in Michigan-based early stage companies. www.venturemichigan.com

Grand Angels www.grandangels.org

Federal Funding Opportunities are listed in the SSTI Weekly Funding Supplement offered by the federal government, foundations and other industries. www.ssti.org/Digest/supplement.htm

Great Lakes Entrepreneur’s Quest www.gleq.org

Venture and Angel Groups

Great Lakes Angels www.glangels.org

Hartwick Capital www.hartwickcapital.com MacBeedon Partners LLC www.macbeedon.com

l Ferris State University www.ferris.edu (231) 591-5983 l Grand Valley State University www.gvsu.edu/research_dev (616) 331-2281 l Michigan State University http://www.oip.msu.edu/ (517) 355-2186 l Michigan Technical University www.admin.mtu.edu/adv/cs/ (906) 487-2228

Ann Arbor Angels www.annarborangels.org

Michigan Venture Capital Association www.michiganvca.org

Apjohn Group, LLC www.apjohnventures.com

North Coast Technology Investors www.northcoastvc.com

Arbor Partners www.arborpartners.com

Renaissance Venture Capital Fund www.renvcf.com

Arboretum Ventures www.arboretumvc.com

Seneca Partners www.senecapartners.com

Ardesta, LLC www.ardesta.com

Sigvion Capital www.sigvion.com

l Saginaw Valley State University http://www.svsu.edu/cbed (989) 964-4047

Beringea www.beringea.com

Southwest Michigan First Life Science Fund www.southwestmichiganfirst.com

l University of Michigan www.techtransfer.umich.edu (734) 763-0614

TGap Ventures www.tgapventures.com

l Van Andel Research Institute www.vai.org (616) 234-5000

BioStar Ventures www.biostarfund.com Bridge Street Capital www.bridgestreetcapital.com Capital Community Angels www.capitalcommunityangels.org Capital Strategies Group www.capitalstrategiesgroup.com Detroit Community Loan Fund www.detroitrenaissance.com Dow Venture Capital www.dow.com/venture EDF Ventures www.edfvc.com Entrepreneurs and Investors Exchange www.EntrepreneurInvestorExchange.com First Angels www.swmfirst.com/First_Angels.cfm Fletcher Spaght Ventures www.fletcherspaght.com/ventures

Wolverine Venture Fund www.zli.bus.umich.edu/wvf

University Research and Technology Transfer Michigan Universities Commercialization Initiative (MUCI) complements and enhances technology transfer functions at Michigan academic and research institutions by supporting commercialization of Intellectual Property. www.muci.org Technology Transfer Offices: l Central Michigan University www.orsp.cmich.edu (989) 774-4000 l Eastern Michigan University www.ord.emich.edu (734) 487-3090

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l Northern Michigan University webb.nmu.edu/Departments/TOS (906) 227-2190 l Oakland University www2.oakland.edu/research (248) 370-2552

l Wayne State University www.techtransfer.wayne.edu (313) 577-5541 l Western Michigan University www. www.brcc.wmich.edu (269) 544-1072 University Research Corridor is an alliance between Michigan’s three major research universities to transform, strengthen and diversify the state’s economy. The partners, Michigan State University, the University of Michigan and Wayne State University, spark regional economic development via invention, innovation and technology transfer, by educating a work force prepared for the knowledge economy, and by attracting smart and talented people to Michigan. www.urcmich.org

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

SmartZones and Business Accelerators SmartZonesTM provide distinct geographical locations where technology-based firms, entrepreneurs and researchers locate in close proximity to all of the community assets that assist in their endeavors. SmartZoneTM technology clusters promote resource collaborations between universities, industry, research organizations, government and other community institutions, growing technologybased businesses and jobs. New and emerging businesses in SmartZoneTM technology clusters are primarily focused on commercializing ideas, patents and other opportunities surrounding corporate, university or private research institute R&D efforts. www.michigan.org/smartzones l Ann Arbor/Ypsilanti: Ann Arbor SPARK, University of Michigan, Eastern Michigan University 201 S. Division St., Suite 430 Ann Arbor, MI 48104 (734) 761-9317 www.AnnArborUSA.org Contact: Michael Finney

l Detroit/Woodward Technology Corridor: TechTown Wayne State University 440 Burroughs, Entrepreneurial Suite Detroit, MI 48202 (313) 879-5250 www.techtownwsu.org Contact: Randal Charlton l Grand Rapids: West Michigan Science & Technology Initiative Grand Valley State University, Van Andel Institute 301 Michigan St NE, Suite 536 Grand Rapids, MI 49503 (616) 331-5840 www.wmsti.org Contact: Linda Chamberlain l Houghton/Hancock: Michigan Tech Enterprise Corporation Michigan Technical University Advance Technology Development Complex 101 West Lakeshore Drive Houghton, MI 49931 (906) 487-7000 www.mtecsmart.com Contact: Carlton K. Crothers

l Automation Alley Lawrence Institute of Technology, Oakland University Automation Alley Technology Center 2675 Bellingham Rd Troy, MI 48083 (248) 457-3200 www.automationalley.com Contact: Tom Anderson

l Jackson Technology Park Baker College, Jackson Community College, Spring Arbor University 3925 County Farm Road Jackson, MI 49201 (517) 788-4455 www.enterprisegroup.org Contact: Scott Fleming

l Battle Creek Aviation & e-Learning Western Michigan University, Kellogg Community College 4950 West Dickman Rd. Battle Creek, MI 49037 (269) 962-7526 www.bcunlimited.org Contact: Karl Dehn

l Kalamazoo: WMU Business Technology & Research Park Western Michigan University 4717 Campus Drive, #100 Kalamazoo, MI 49008 (269) 353-1823 www.kazoosmic.com Contact: Robert DeWit

BioMatters | Spring 2009

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l Lansing/East Lansing: University Corporate Research Park 2727 Alliance Drive, Ste. C Lansing, MI 48910 (517) 432-1753 ucrp.msu.edu Contact: George Benson l Macomb Technology Advancement Oakland University 6555 15 Mile Road Sterling Heights, MI 48312 (586) 463-2542 www4.oakland.edu/?id=6871&sid=213 Contact: Luke Bonner l Midland: Mt. Pleasant SmartZoneTM Satellite MidMichigan Innovation Center 4520 E. Ashman Rd., Suite M Midland, MI 48642 (989) 839-2333 www.midmichiganinnovationcenter.org Contact: Brent Case l Mt. Pleasant: Center for Applied Research & Technology Central Michigan University 2625 Denison Drive Mt. Pleasant, MI 48858 (989) 774-2424 www.cmurc.com Contact: Ken Van Der Wende l Muskegon Lakeshore Grand Valley State University 380 W. Western Ave, Suite 202 Muskegon, MI 49440 (231) 724-6702 www.muskegonareafirst.org Contact: Ed Garner l Rochester Hills: Oakland University INCubator Oakland University Shotwell-Gustafson Pavilion, Oakland University 2200 N. Squirrel Road Rochester, MI 48309 (248) 648-4800 www.oakland.edu/ouinc Contact: David Spencer

D I R E C TO RY & R E S O U R C E G U I D E

l Sault St. Marie Economic Development Corp.

1301 West Easterday Ave. Sault Ste. Marie, MI 49783 (906) 635-9131 www.saultedc.com Contact: Jim Hendricks l Wayne County: Pinnacle Aeropark University of Michigan, Wayne State University, Detroit Metropolitan Airport 600 Randolph Street, Third Floor Detroit, MI 48226 (313) 224-6076 www.waynecounty.com Contact: Dave Tyler

Selected Michigan County Economic Development Organizations Alcona ww.alconacountymi.com Allegon www.allegancounty.org Bay www.baycounty-mi.gov/EACD/EconomicDevelopment.aspx Benzie www.benziecountyedc.com Berrien www.berriencounty.org Calhoun www.calhouncountymi.org Genesee www.thegrcc.org Houghton www.houghtoncounty.net Ingham www.ingham.org/DV/developm.htm Ionia www.icea-mi.org Isabella www.mmdc.org Jackson www.co.jackson.mi.us/JCinfo.asp

Kalamazoo www.southwestmichiganfirst.com

St. Joseph www.sjcedc.com

Kent www.rightplace.org

Traverse Bay www.tcchamber.org

Leelanau www.leelanaucounty.com/edc.asp

Van Buren www.vbco.org/econdev0003.asp

Lenawee www.lenawee.mi.us

Washtenaw www.AnnArborUSA.org

Livingston www.livingstonedc.com

Wayne www.waynecounty.com/jed

Manistee www.allianceforeconomicsuccess.com

For a complete list of Michigan economic development organizations, please visit www.ecodevdirectory.com/Michigan.htm

Marquette www.marquette.org/economic_main.html Macomb www.macombcountymi.gov/MCPED Mason www.masoncountyedc.com Midland www.midlandtomorrow.org Monroe www.monroecountyidc.com Muskegon www.muskegonareafirst.org Newaygo www.ncedo.org Oakland www.oakgov.com/peds Ontonagon www.ontcoedc.com Otsego www.otsego.org/econdev.htm Ottawa www.co.ottawa.mi.us Saginaw www.saginawfuture.com Sanilac www.sanilaccounty.org Schoolcraft www.schoolcraftedc.com St. Clair www.edascc.com

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BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

21st Century Therapeutics, Inc. 52673 Seven Oaks, Suite 105 Shelby Township, MI 48316 (313) 874-4879 Pharmaceutical & Therapeutics

3D Biomatrix 401 West Morgan Ann Arbor, MI 48108 (734) 945-8131 Research Tools A

AAPharmaSyn LLC 3985 Research Park Drive Ann Arbor, MI 48108 (734) 213-2123 www.aapharmasyn.com Contract R&D • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Aastrom Biosciences, Inc. 24 Frank Lloyd Wright Drive, Lobby K Ann Arbor, MI 48105 (734) 930-5555 www.aastrom.com Pharmaceutical & Therapeutics • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Abbott Nutrition 901 North Centerville Road Sturgis, MI 49091 (269) 651-0787 www.abbott.com Pharmaceutical & Therapeutics

Absolute Analytical, Inc. 240 West Auburn Road Rochester Hills, MI 48307 (248) 844-2800 Contract R&D, Industrial & Environmental

Access Business Group 7575 Fulton Street East Ada, MI 49355 (616) 787-6767 www.accessbusinessgroup.com Contract R&D

Accord Biomaterials, Inc. 3550 West Liberty Road, Suite 3 Ann Arbor, MI 48103 (734) 995-9089 www.accordbiomaterials.com Medical Devices

Accumed Systems Inc.

1025 East Maple Road, Suite 210 Birmingham, MI 48009 (248) 901-0525 www.axt-medical.com Medical Devices

Accuri Cytometers

Advantage Capital Partners

173 Parkland Plaza Ann Arbor, MI 48103 (734) 994-8000 www.AccuriCytometers.com Research Tools

7733 Forsyth Boulevard, Suite 1850 St. Louis, MO 63015 www.advantagecap.com Venture Capital ••••••••••••••••••••••••••••••••••••

• • • • • • • • • •••••••••••••••••••••••••••

AEGIS Environments

Acuity Medical, Inc. 10524 Grand River Brighton, MI 48116 (810) 229-5828 www.acuitymedical.com Medical Devices

2205 Ridgewood Drive Midland, MI 48642 (800) 241-9186 www.microbeshield.com Industrial & Environmental, Medical Devices, Contract R&D

Adamlab, LLC 55 East Long Lake Road, Suite 337 Troy, MI 48085 (248) 362-9603 www.adamlab.com Medical Devices

Adeona Pharmaceuticals 3930 Varsity Drive Ann Arbor, MI 48108 (734) 332-7800 www.adeonapharma.com Pharmaceutical & Therapeutics

AFID Therapeutics Inc. 3900 Collins Road, Suite 1029 Lansing, MI 48910 (517) 336-4641 www.afidtherapeutics.com Pharmaceutical & Therapeutics ••••••••••••••••••••••••••••••••••••

Agfa Corporation www.agfa.com/usa/en/he/index.jsp Medical Devices, Informatics

Agrium ADMETRx 4717 Campus Drive Kalamazoo, MI 49008 (269) 372-3272 www.admetrx.com Contract R&D • • • • • • • • • •••••••••••••••••••••••••••

Advanced Photonix Inc. 2925 Boardwalk Ann Arbor, MI 48104 (734) 864-5639 www.advancedphotonix.com Medical Devices, Research Tools

Advanced Sensor Technologies, Inc. 300 River Place, Suite 6850 Detroit, MI 48207 (248) 553-9375 www.advsensortech.com Medical Devices

• •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

BioMatters | Spring 2009

Advanced X-Ray Technology, Inc.

6109 Jackson Ann Arbor, MI 48103 (734) 930-0461 www.accumedsystemsinc.com Medical Devices

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2405 Vassar Road Reese, MI 48757 (989) 752-2138 www.agrium.com Agriculture & Food

AI Medical Devices, Inc. 311 Turner Road Williamston, MI 48895 (517) 881-8804 www.aimedicaldevices.com Medical Devices

Air Force Inc. 933 Butternut Drive Holland, MI 49424 (616) 399-8511 www.dentalairforce.com Medical Devices

AIS Consulting 4343 Concourse Drive, Suite 220 Ann Arbor, MI 48108 (734) 769-7470 www.aisconsulting.biz Contract R&D, Informatics

D I R E C TO RY & R E S O U R C E G U I D E

Akervall Technologies

American Society for Microbiology

5520 Stonevalley Drive Ann Arbor, MI 48105 (734) 485-2949 Medical Devices

9205 Huron River Drive Dexter Township, MI 48130 (734) 845-3661 www.mi-asm.org Association/Non-profit

Albemarle Corporation 1421 South Kalamazoo Street South Haven, MI 49090 (269) 637-8474 www.albemarle.com Contract R&D

AP Bio-Consulting LLC

40799 Coachwood Circle Northville, MI 48168 (413) 451-8225 www.apbioconsulting.com Consulting ••••••••••••••••••••••••••••••••••••

American Society of Employers 23815 Northwestern Highway Southfield, MI 48075 (248) 353-4500 www.aseonline.org Association/Non-profit

Alivio Corporation 20429 Honor Highway Interlochen, MI 49643 (231) 275-1345 www.aliviocorp.com Medical Devices

• • • • • • • • • •••••••••••••••••••••••••••

Apjohn Group, LLC 350 East Michigan Avenue, Suite 500 Kalamazoo, MI 49007 (269) 349-8999 www.apjohngroup.com Venture Capital ••••••••••••••••••••••••••••••••••••

Alluvium Biosciences Inc. 789 N. Dixboro Road Ann Arbor, MI 48105 (734) 276-4921 Contract R&D, Industrial & Environmental, Pharmaceuticals & Therapeutics

Amgen 9935 North Valley Hill Drive Mequon, WI 53092 (262) 240-9961 www.amgen.com Pharmaceutical & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

Amigo Mobility International

AlphaCore Pharma 2900 Huron Parkway, Suite 5 Ann Arbor, MI 48105 (734) 330-0265 Pharmaceutical & Therapeutics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

SILVER SPONSOR

Altarum Institute 3520 Green Court, Suite 300 P.O. Box 134001 Ann Arbor, MI 48105 (734) 302-4600 www.altarum.org University/Institution/Hospital • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

6693 Dixie Highway Bridgeport, MI 48722 (989) 921-5062 www.myamigo.com Medical Devices

Angott Medical Products, LLC 442 Five Gaits Court Bloomfield Hills, MI 48304 (248) 444-1492 Medical Devices

Ann Arbor Clinical Research 203 South Zeeb Road, Suite 105 Ann Arbor, MI 48103 (734) 926-0957 www.annarborclinicalresearch.com Contract R&D

American Dental Technologies, Inc. 28265 Beck Road, Suite C-22 Wixom, MI 48393 (800) 359-1959 www.americandentaltech.com Medical Devices

American Diabetes Association 30300 Telegraph Road, Suite 117 Bingham Farms, MI 48025 (248) 433-3830 www.diabetes.org Association/Non-profit

ApoLife, Inc. 100 River Place, #6800 Detroit, MI 48207 (313) 446-2625 www.apolife.com Research Tools, Contract R&D ••••••••••••••••••••••••••••••••••••

Aptuit Consulting, Inc 91 Hartwell Avenue Lexington, MA 02421 (781) 778-0418 www.aptuitconsulting.com Consulting ••••••••••••••••••••••••••••••••••••

AquaBiochip, LLC 1012 North Walnut Street, Suite 101 Lansing, MI 48906 (517) 402-2692 www.aquabiochip.com Contract R&D, Diagnostics

Arbor Preclinical & Consulting, LLC Ann Arbor SPARK 201 South Division, Suite 430 Ann Arbor, MI 48104 (734) 761-9317 www.AnnArborUSA.org Government/Economic Development • • • • • • • • • •••••••••••••••••••••••••••

Antel BioSystems, Inc 3655 Forest Road Lansing, MI 48910 (800) 631-3510 www.antelbio.com Contract R&D, Diagnostics

57

(734) 330-4396 www.arborpcc.com Contract R&D

Arbor Research Collaborative for Health 315 West Huron Street, Suite 360 Ann Arbor, MI 48103 (734) 665-4108 www.arborresearch.org Contract R&D, Informatics

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

Arboretum Ventures

Assay Designs, Inc.

Automation Alley

334 East Washington Street Ann Arbor, MI 48104 (734) 998-3688 www.arboretumvc.com Venture Capital

5777 Hines Drive Ann Arbor, MI 48108 (734) 668-6113 www.assaydesigns.com Research Tools, Diagnostics

2675 Bellingham Troy, MI 48083 (248) 457-3200 www.automationalley.com Government/Econ Dev.

• •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

• • • • • • • • • •••••••••••••••••••••••••••

••••••••••••••••••••••••••••••••••••

Ardesta, LLC

BRONZE SPONSOR

201 South Main Street, 10th Floor Ann Arbor, MI 48104 (734) 994-7000 www.ardesta.com Venture Capital

Asterand, Inc. TechOne Building, 440 Burroughs, Suite 501 Detroit, MI 48202 (313) 263-0960 www.asterand.com Research Tools, Contract R&D • • • • • • • • • •••••••••••••••••••••••••••

Arivium, Inc.

ATEK Medical Manufacturing

354 Glen Arbor Drive NE Rockford, MI 49341 (616) 292-5018 www.arivium.com IT Services & Consulting • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

620 Watson SW Grand Rapids, MI 49504 (616) 643-5200 www.atekcompanies.com Contract R&D, Medical Devices

Armune BioScience, Inc.

Ateq Corporation

350 East Michigan Avenue, Suite 500 Kalamazoo, MI 49007 (269) 349-8870 www.armune.com Diagnostics

42000 Koppernick Road Canton, MI 48187 (734) 451-9449 www.atequsa.com Medical Devices PATRON

Ash Stevens 5861 John C. Lodge Freeway Detroit, MI 48202 (313) 872-6400 www.ashstevens.com Contract R&D • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

ASI Instruments, Inc. 12900 East Ten Mile Road Warren, MI 48089 (586) 756-1222 www.asi-instruments.com Medical Devices, Research Tools

Aspen Surgical Products, Inc. 6945 Southbelt Drive SE Caledonia, MI 49316 (616) 698-7100 www.aspensurgical.com Medical Devices, Research Tools

BioMatters | Spring 2009

Atodyne Technologies LLC 4699 Pontiac Trail Ann Arbor, MI 48105 (734) 761-5282 www.atodyne.com Medical Devices

AVAcore Technologies 333 Parkland Plaza Drive, Suite 700 Ann Arbor, MI 48103 (888) 282-2673 www.avacore.com Medical Devices

Avalon Laboratories LLC 301 Michigan Street, Suite 500 Grand Rapids, MI 49503 (616) 331-5843 www.avalonlabs.com Medical Devices, Contract R&D

Avicenna Medical Systems, Inc. 3090 Dhu Varren Court Ann Arbor, MI 48105 (888) 284-4080 www.avicenna-medical.com Informatics

Avidimer Therapeutics, Inc. P.O. Box 7735 Ann Arbor, MI 48107 (866) 229-1387 www.avidimer.com Pharmaceutical & Therapeutics

Axenic Dental, Inc.

AureoGen Biosciences, Inc. 6475 Technology Avenue, Suite C Kalamazoo, MI 49009 (269) 353-3805 www.aureogen.com Pharmaceutical & Therapeutics

Aursos, Inc. 350 East Michigan Avenue, Suite 500 Kalamazoo, MI 49007 (269) 381-4408 www.aursos.com Pharmaceutical & Therapeutics

Autocam Corporation 4436 Broadmore SE Kentwood, MI 49512 (800) 747-6978 www.autocam.com Medical Devices

58

259 East Michigan Avenue, Suite 409 Kalamazoo, MI 49007 (269) 349-8870 Medical Devices

Axsys Technologies, Inc. 2909 Waterview Drive Rochester Hills, MI 48309 (248) 293-2900 www.axsys.com Medical Devices

AzoRx, Inc. 526 Jasper Street Kalamazoo, MI 49007 (269) 585-5953 www.azorx.com Contract R&D

D I R E C TO RY & R E S O U R C E G U I D E

B

Bank of Ann Arbor 125 South Fifth Avenue P.O. Box 8009 Ann Arbor, MI 48104 (734) 662-1600 www.boaa.com Banking • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Bauer BioMedical, LLC 2526 Denison Drive Mt. Pleasant, MI 48854 (810) 397-2882 Diagnostics

Bayer CropScience 1740 North Whitehall Muskegon, MI 49445 (231) 719-3000 www.bayercropscience.com Agriculture & Food

Bayer HealthCare 6549 Braemar Avenue Noblesville, IN 46069 (317) 774-8069 www.bayerhealth.com Pharmaceutical & Therapeutics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Beaumont Commercialization Center 3601 West Thirteen Mile Road Royal Oak, MI 48073 (248) 551-0255 www.beaumontcommercializationcenter.com Contract R&D • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

BRONZE SPONSOR

Beaumont Hospitals 3601 West Thirteen Mile Road Royal Oak, MI 48073 (248) 551-8550 www.beaumonthospitals.com University/Institution/Hospital • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Beaumont Services Company LLC

Biodiscovery, LLC

3601 West Thirteen Mile Road Royal Oak, MI 48073 (248) 551-3010 www.beaumontservices.com Consulting

5992 Plymouth Road Ann Arbor, MI 48105 (734) 998-0751 www.Mycroarray.com Research Tools, Contract R&D

• • • • • • • • • •••••••••••••••••••••••••••

••••••••••••••••••••••••••••••••••••

Becker Orthopedic

BioFlow Technology, Inc

635 Executive Drive Troy, MI 48083 (248) 588-7480 www.beckerorthopedic.com Medical Devices

11477 North Shore Drive Whitmore Lake, MI 48189 (734) 223-1946 www.bioflowtech.com Research Tools, Medical Devices

Becton Dickinson - Difco Laboratories

Bio-lab, Inc., A Chemtura Company

920 Henry Street Detroit, MI 48201 (313) 442-8800 www.bd.com Research Tools, Diagnostics

1400 East Michigan Street Adrian, MI 49221 (517) 265-6138 www.chemtura.com Industrial & Environmental

Berry & Associates, Inc.

BioLumix, Inc

2434 Bishop Circle East Dexter, MI 48130 (734) 426-3787 www.berryassoc.com Research Tools

3830 Packard Road, Suite 180 Ann Arbor, MI 48108 (734) 973-5870 www.mybiolumix.com Research Tools, Medical Devices

Better Rehab, LLC

Biomedical Diagnostics, LLC

1170 Morehead Court Ann Arbor, MI 48104 (734) 604-1966 Informatics

5692 Plymouth Road, Suite B Ann Arbor, MI 48105 (734) 913-9040 www.bio-diagnostics.com Diagnostics

Bio Logic Engineering, Inc. 1675 N. Lima Center Road Dexter, MI 48130 (734) 433-9256 www.biologicengineering.com Medical Devices

Bio-Chem Laboratories, Inc. 1049 28th Street, SE Grand Rapids, MI 49508 (616) 248-4900 www.bio-chem.com/Home/tabid/36/Default.aspx Contract R&D

Bio-Coat Inc. 21249 Bridge Street Southfield, MI 48034 (248) 352-4570 Medical Devices

BioMedPharmIS, Ltd. 350 East Michigan Avenue, Suite 410 Kalamazoo, MI 49007 (269) 488-3301 www.biomedpharmis.com Contract R&D ••••••••••••••••••••••••••••••••••••

BioMedware Inc. 516 North State Street Ann Arbor, MI 48104 (734) 913-1098 www.biomedware.com Informatics

Biomide 21 Kercheval Avenue, Suite 330 Grosse Pointe Farms, MI 48236 (313) 886-0589 Pharmaceuticals & Therapeutics

59

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

Bio-Nano Power LLC

Biotech Clinical Laboratories

2625 Denison Dr. Mt. Pleasant, MI 48858 (616) 682-0367 Medical Devices

24469 Indoplex Circle Farmington Hills, MI 48335 (248) 426-9800 www.biotechclinical.com Contract R&D, Diagnostics

BioPharma Data Services 1461 Scio Ridge Ct Ann Arbor, MI 48103 (734) 255-1038 www.BioPharmaDataServices.com Contract R&D, Informatics

Biophotonic Solutions, Inc. 3590 Breezy Point Drive Okemos, MI 48864 (517) 881-4562 www.biophotonicsolutions.com Research Tools, Medical Devices

Biopolymer Innovations 16647 Chandler Road East Lansing, MI 48823 (517) 432-3044 www.biopolymerinnovations.com Pharmaceutical & Therapeutics, Industrial & Environmental

BioPro 17 17th Street Port Huron, MI 48060 (810) 982-7777 www.bioproimplants.com Medical Devices

Biosciences Research & Commercialization Center Center for Technology Excellence 4717 Parkview Campus Drive Kalamazoo, MI 49008 (269) 544-1072 www.brcc.wmich.edu University/Institution/Hospital • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Biosol, Ltd. 206 South Fifth Avenue, Suite 500 Ann Arbor, MI 48104 (313) 994-5300 www.liposol.com Research Tools

BioSTAT Consultants, Inc. 528 West Centre Avenue Portage, MI 49024 (269) 329-7976 www.biostat.net Contract R&D

BioMatters | Spring 2009

Borgess Research Institute

SUPPORTER

Biotechnology Business Consultants (BBC) 803 North Main Street Ann Arbor, MI 48104 (734) 930-9741 www.bioconsultants.com Consulting • • • • • • • • • •••••••••••••••••••••••••••

Biotectix 2900 Huron Parkway Ann Arbor, MI 48104 (781) 353-6404 www.biotectix.com Diagnostics, Research Tools, Industrial & Environmental • • • • • • • • • •••••••••••••••••••••••••••

Biotronic Neural Monitoring Specialists 812 Avis Drive Ann Arbor, MI 48108 (866) 856-4404 www.biotronic.com Medical Devices

1521 Gull Road Kalamazoo, MI 49048 (269) 226-5407 www.research.borgess.com University/Institution/Hospital ••••••••••••••••••••••••••••••••••••

BoroPharm, Inc. 39555 Orchard Hill Place Novi, MI 48375 (888) 366-1496 www.boropharm.com Contract R&D

Bremer Prosthetics, Inc. G3487 South Lindin Road, Suite U Flint, MI 48507 (810) 733-3375 www.bremerprosthetics.com Medical Devices

Brenner Orthotic and Prosthetic Labs 32975 West Eight Mile Road Livonia, MI 48152 (810) 615-0601 Medical Devices

Bridge Organics Co.

Birchbrook Technologies LLC 53470 Andrew Circle New Baltimore, MI 48047 (586) 648-8267 www.birchtek.com Medical Devices

Bluestone Realty Advisors 325 East Eisenhower, Suite 308 Ann Arbor, MI 48108 (734) 665-6500 www.blueadvisors.com Real Estate • • • • • • • • • •••••••••••••••••••••••••••

BlueWare, Inc. 3060 West 13th Street Cadillac, MI 49601 (231) 779-0224 www.blueware.net Informatics, Contract R&D

60

311 West Washington Street Vicksburg, MI 49097 (616) 649-4200 www.bridgeorganics.com Contract R&D ••••••••••••••••••••••••••••••••••••

Brinks, Hofer, Gilson & Lione 524 S. Main Street, Suite 200 Ann Arbor, MI 48104 (734) 994-6285 www.brinkshofer.com Attorneys ••••••••••••••••••••••••••••••••••••

Brooks Kushman 1000 Town Center, Suite 2200 Southfield, MI 48075 (248) 358-4400 ext. 2770 www.brookskushman.com Attorneys ••••••••••••••••••••••••••••••••••••

D I R E C TO RY & R E S O U R C E G U I D E

Brown & Brown of Detroit 305 East Eisenhower Parkway, Suite 100 Ann Arbor, MI 48108 (734) 995-4444 ext. 3781 www.alcos.com Insurance Provider

Caltech Industries, Inc.

Cayman Chemical Company

4520 East Ashman Road, Suite C Midland, MI 48642 (989) 496-3110 www.caltechind.com Industrial & Environmental, Agriculture & Food

1180 East Ellsworth Road Ann Arbor, MI 48108 (734) 971-3335 www.caymanchem.com Research Tools, Diagnostics

• • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Canadian Consulate General Bruce Johnson Service Co. Inc. 4363 South Old US Hwy 23 Brighton, MI 48114 (810) 227-5130 www.BruceJohnsonService.com Lab Equipment

600 Renaissance Center, Suite 1100 Detroit, MI 48243 (313) 446-7016 www.detroit.gc.ca Government/Econ Dev.

1953 South Harvey Street Muskegon, MI 49442 (231) 726-3171 www.bandj.com Industrial & Environmental, Agriculture & Food

Butzel Long 350 South Main Street, Suite 300 Ann Arbor, MI 48104 (734) 213-3435 www.butzel.com Attorneys • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

C

Cell Culture Characterization Services

Capital Advisors Group, Inc. 29 Crafts Street, Ste. 270 Newton, MA 02458 (617) 630-8100 www.capitaladvisors.com Venture Capital • • • • • • • • • •••••••••••••••••••••••••••

SUPPORTER

Caraco Pharmaceutical Laboratories, Ltd. 1150 Elijah McCoy Drive Detroit, MI 48202 (313) 871-8400 www.caraco.com Pharmaceutical & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

CardiArc Caladium Consulting 1682 Baker Road Dexter, MI 48130 (734) 476-5232 www.caladiumconsulting.com Consulting • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Calibrate, Inc. - The Pipet People 3600 Green Court, Ste. 400 Ann Arbor, MI 48105 (919) 929-3004 www.pipetpeople.com Lab Equipment • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

4717 Campus Drive Kalamazoo, MI 49008 (269) 353-5555 www.ceetox.com Contract R&D ••••••••••••••••••••••••••••••••••••

• • • • • • • • • •••••••••••••••••••••••••••

• • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Burdick & Jackson

CeeTox, Inc.

7444 Haggerty Road Canton, MI 48187 (734) 207-3440 www.cardiarc.com Medical Devices

1872 North Adams Rochester Hills, MI 48306 (248) 656-2542 Contract R&D, Diagnostics

Central Michigan University Office of Research and Sponsored Programs 251 Foust Hall Mt. Pleasant, MI 48859 (989) 774-6777 www.orsp.cmich.edu University/Institution/Hospital ••••••••••••••••••••••••••••••••••••

Central Michigan University Research Corporation 2625 Denison Drive Mt. Pleasant, MI 48858 (989) 774-2424 www.cmurc.com University/Institutions/Hospitals

Cascade Hemophilia Consortium 210 East Huron, Suite D Ann Arbor, MI 48104 (734) 996-3300 www.hemoalliance.org Association/Non-profit

Cascade Life Solutions 3710 Sysco Court, SE Grand Rapids, MI 49512 (616) 977-2515 Medical Devices

••••••••••••••••••••••••••••••••••••

Centromine, Inc. 3756 Plaza Drive Ann Arbor, MI 48108 (734) 352-0020 www.centromine.com Informatics

Cerenis Therapeutics Inc. 900 Victors Way, Suite 280 Ann Arbor, MI 48108 (734) 769-1110 www.cerenis.com Pharmaceutical & Therapeutics ••••••••••••••••••••••••••••••••••••

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BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

Cerise Nutraceuticals, Inc.

Clean Air Technology

Conceivex

1670 Barlow Street, Suite A Traverse City, MI 49686 (231) 933-3300 www.cherrylotion.com Pharmaceutical & Therapeutics, Agriculture & Food

41105 Capital Canton, MI 48187 (734) 459-6320 www.cleanairtechnology.com Research Tools

P.O. Box 31 5 East Main Street Saranac, MI 48881 (616) 452-2700 www.conceptionkit.com Medical Devices

CFI Medical Solutions (Contour Fabricators, Inc.)

3139 South Wayne Road Wayne, MI 48184 (734) 722-6290 www.clas.org Association/Non-profit

14241 Fenton Road Fenton, MI 48430 (810) 750-5300 www.cfimedical.com Medical Devices, Contract R&D

Charles River 9801 Shaver Road Portage, MI 49002 (269) 327-4248 www.criver.com Contract R&D

Clinical Ligand Assay Society

ClinSite, Inc. 24 Frank Lloyd Wright Drive, Lobby A Ann Arbor, MI 48106 (734) 930-3700 www.clinsite.com Contract R&D

ClinXus

Christian Roux Ltd. 561 Woodlawn Ypsilanti, MI 48197 (734) 732-6671 www.hurricanecrutch.com Medical Devices PREFERRED PROVIDER

Chubb Group of Insurance Companies 5440 Corporate Drive, Suite 300 P.O. Box 7078 Troy, MI 48007 (734) 741-1850 www.chubb.com Insurance Provider • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Cielo MedSolutions 3520 Green Court, Ste. 425 Ann Arbor, MI 48104 (734) 827-1000 www.cielomedsolutions.com Informatics

City of Marshall Economic Development 323 West Michigan Marshall, MI 49068 (269) 781-5183 ext. 1156 www.cityofmarshall.com Government/Economic Devevelopment • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Cook-DeVos Center for Health Sciences 301 Michigan Street NE, Suite 537 Grand Rapids, MI 49503 (616) 331-5854 www.clinxus.com Association/Non-profit

CNVGenes LLC 4995 Arrowhead Road West Bloomfield, MI 48323 (248) 682-3368 www.cnvgenes.com Research Tools, Diagnostics • • • • • • • • • •••••••••••••••••••••••••••

College Park Industries 17505 Helro Road Fraser, MI 48026 (586) 294-7950 www.college-park.com Medical Devices

Collet Consulting, LLC 405 Awixa Road Ann Arbor, MI 48104 (734) 358-9015 Consulting

11490 East G Avenue Galesburg, MI 49053 (269) 665-4420 www.contentedhearts.com Informatics

Corium International, Inc. 4558 50th Street Grand Rapids, MI 49512 (616) 656-4563 www.coriumintl.com Contract R&D, Pharmaceutical & Therapeutics PREFERRED PROVIDER

Cornerstone Benefits, LLC 1450 West Long Lake Road, Suite 250 Troy, MI 48098 (248) 641-3609 www.cornerstonebenefits.com Insurance Provider ••••••••••••••••••••••••••••••••••••

Covalent Medical, Inc. 4750 South State Street, Suite 301 Ann Arbor, MI 48108 (734) 429-2451 www.covamed.com Medical Devices, Research Tools

Coy Laboratory Products Inc 14500 Coy Drive Grass Lake, MI 49240 (734) 475-2200 www.coylab.com Research Tools, Medical Devices ••••••••••••••••••••••••••••••••••••

• • • • • • • • • •••••••••••••••••••••••••••

Compendia Bioscience 110 Miller Avenue, Floor 2 Ann Arbor, MI 48104 (734) 929-3909 www.compendiabio.com Informatics, Contract R&D • • • • • • • • • •••••••••••••••••••••••••••

BioMatters | Spring 2009

Contented Hearts, Inc.

62

CRB Consulting Engineers 5250 Lovers Lane, Suite 130 Kalamazoo, MI 49002 (269) 342-9474 ext. 1046 www.crbusa.com Facilities & Construction ••••••••••••••••••••••••••••••••••••

D I R E C TO RY & R E S O U R C E G U I D E

CVR Gobal, Inc. Creative Technology Services 7444 Haggerty Road Canton, MI 48187 (734) 207-2600 www.ctsmius.com Medical Devices, Contract R&D • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Crissman Toxicologic Pathology, LLC 2887 Oakhaven Court Midland, MI 48642 (989) 631-2790 Contract R&D

Critech Research, Inc. 525 Avis Drive, Suite 7 Ann Arbor, MI 48108 (734) 668-0005 www.critech.com Contract R&D, Informatics

Critical Signal Technologies

18186 Park Lane Grosse Ile, MI 48138 (734) 604-6023 www.cvrgloabl.com Medical Devices

Delphi Medical Systems 5725 Delphi Drive Troy, MI 48098 (248) 813-8061 www.delphimedical.com Medical Devices

D

Danmar Products Inc. 221 Jackson Industrial Drive Ann Arbor, MI 48103 (800) 783-1998 www.danmarproducts.com Medical Devices

Data Integrated Scientific Systems 8031 Main Street, Suite 301 Dexter, MI 48130 (734) 426-4995 www.dissdata.com Informatics, Research Tools

22600 Haggerty Road Farmington Hills, MI 48335 (888) 557-4462 www.criticalsignaltechnologies.com Medical Devices

Davis Dental Labs

CSM Group

DavisMade, Inc

100 West Michigan Avenue, Suite 200 Kalamazoo, MI 49007 (269) 746-5600 www.csmgroup.com Facilities & Construction

5830 Crossroad Commerce Parkway Wyoming, MI 49519 (616) 261-9191 www.dentalservices.net/davis Medical Devices 2511 Davison Road Flint, MI 48506 (810) 742-0581 www.standingdani.com Medical Devices

• • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Custom Biogenic Systems 150 Shafer Drive Romeo, MI 48065 (800) 523-0072 www.custombiogenics.com Research Tools, Medical Devices

Cutting Image Histology, LLC 800 Technology Drive Ann Arbor, MI 48108 (734) 945-9077 www.cuttingimagehistology.com Contract R&D, Diagnostics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Cybernet Medical, Cybernet Systems Corporation 727 Airport Boulevard Ann Arbor, MI 48108 (800) 292-3763 www.cybernetmedical.com Informatics, Medical Devices

DBA Analytical (an NSF International Company) 789 Dixboro Road Ann Arbor, MI 48113 (734) 769 8010 www.dba-global.com Contract R&D

••••••••••••••••••••••••••••••••••••

Dendritech, Inc. 3110 Schuette Drive Midland, MI 48642 (989) 496-2016 www.dendritech.com Industrial & Environmental

Dendritic Nanotechnologies, Inc. 2625 Denison Drive, Suite B Mt. Pleasant, MI 48858 (989) 774-6565 www.dnanotech.com Industrial & Environmental

Der-Balian Inc 5027 Collins Road Manistee, MI 49660 (650) 380-1591 Consulting ••••••••••••••••••••••••••••••••••••

Dermanaut 702 Dwight Street Ypsilanti, MI 48198 (734) 604-8214 www.dermanaut.com Informatics

Detroit R & D, Inc. Metropolitan Center for High Technology (MCHT) 2727 Second Avenue, Suite 4113 Detroit, MI 48201 (313) 961-1606 www.detroitrandd.com Diagnostics, Research Tools

• • • • • • • • • •••••••••••••••••••••••••••

Ddots, Inc.

Detroit Technical Equipment Company

4571 Ellsworth Road Ypsilanti, MI 48197 (734) 434-7734 www.ddots.com Informatics

deCODE genetics 1032 Karl Greimel Drive, Suite 11 Brighton, MI 48114 (810) 220-5300 www.decode.com Pharmaceuticals & Therapeutics, Diagnostics

63

55 East Long Lake Road, PMB #433 Troy, MI 48085 (248) 232-8894 ext. 115 www.detroit-tech.com Lab Equipment ••••••••••••••••••••••••••••••••••••

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

Diagnostic Instruments Inc. 6540 Burroughs Street Sterling Heights, MI 48314 (586) 731-6000 www.diaginc.com Medical Devices, Diagnostics, Research Tools

Draths Industries, LLC

EcoSynthetix

2367 Science Parkway, Suite 2 Okemos, MI 48864 (517) 349-0669 www.drathscorporation.com Agriculture & Food, Contract R&D, Industrial & Environmental

3900 Collins Road Lansing, MI 48910 (517) 336-4649 www.ecosynthetix.com Agriculture & Food, Industrial & Environmental

Drug & Laboratory Disposal, Inc.

Eliason Consulting

331 Broad Street Plainwell, MI 49080 (269) 685-9824 www.dld-inc.com Contract R&D, Industrial & Environmental

440 Burroughs TechOne, Suite 320 Detroit, MI 48230 (301) 675-9983 Consulting

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DuPeron Medical Systems

Elkins Innovations, Inc.

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Di-Coat Corp 42900 West Nine Mile Road Novi, MI 48375 (800) 637-9194 www.dicoat.com Manufacturer

Digilab Genomic Solutions 4355 Varsity Drive Ann Arbor, MI 48108 (734) 975-4800 www.genomicsolutions.com Research Tools

Diversified Natural Products 506 East State Street Scottville, MI 49454 (514) 276-3199 www.dnpworld.com

301 Michigan Street, Suite 581 Grand Rapids, MI 49503 (616) 331-5889 Medical Devices

Eloquest Healthcare SILVER SPONSOR

Dykema, PLLC

DNA Software, Inc. 204 East Washington Street Ann Arbor, MI 48104 (734) 222-9080 www.dnasoftware.com Informatics, Contract R&D • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

DNADNB LLC 4995 Arrowhead Road West Bloomfield, MI 48323 (248) 682-3368 Contract R&D, Diagnostics, Medial Devices, Research Tools

Doctor’s Orders, Inc 731 B Construction Court Zeeland, MI 49464 (616) 931-9939 www.do-engineering.com Medical Devices, Contract R&D PREFERRED PROVIDER

Doeren Mayhew 755 West Big Beaver, Suite 2300 Troy, MI 48084 (248) 244-3005 www.doeren.com Accountants, Financial Advisors • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

BioMatters | Spring 2009

3195 South Christy Way Saginaw, MI 48603 (989) 790-5100 www.duperonmedical.com Contract R&D

400 Renaissance Center Detroit, MI 48243 (313) 568-6800 Detroit www.dykema.com Attorneys • • • • • • • • • •••••••••••••••••••••••••••

E

EADevices, Inc. 7752 Primrose Lane Portage, MI 49024 (412) 334-7045 Medical Devices

Early Warning Healthcare Institute 3100 Cross Creek Parkway, Suite 160 Auburn Hills, MI 48326 (248) 371-9000 www.earlywarninghealth.net Diagnostics, Informatics

ECO PHYSICS, INC. 3915 Research Park, Suite A-3 Ann Arbor, MI 48108 (734) 998-1600 www.ecophysics-us.com Medical Devices, Research Tools

Ecology Health Products, Inc. 12941 East Townline Road Goetzville, MI 49736 (906) 297-8770 www.ecologyproducts.com Pharmaceuticals & Therapeutics, Agriculture & Food

64

780 West Eight Mile Road Ferndale, MI 48220 (877) 433-7626 www.eloquesthealthcare.com Pharmaceuticals & Therapeutics

Emerald BioAgriculture Corporation/Auxein Corporation 2123 University Park Drive, Suite 105 Okemos, MI 48864 (517) 882-7370 www.emeraldbio.com Agriculture & Food, Industrial & Environmental

Emergent BioSolutions 3500 Martin Luther King Jr. Boulevard Lansing, MI 48906 (517) 327-1500 www.ebsi.com Pharmaceuticals & Therapeutics, Industrial & Environmental ••••••••••••••••••••••••••••••••••••

Emiliem 4717 Campus Drive Kalamazoo, MI 49009 (415) 421-0222 www.emiliem.com Pharmaceuticals & Therapeutics

Ennew Medical Devices, LLC 2400 N. 6th Street Kalamazoo, MI 49009 (269) 615-5113 Medical Devices

D I R E C TO RY & R E S O U R C E G U I D E

F

Ernst & Young LLP 171 Monroe Avenue NW, Suite 1000 Grand Rapids, MI 49503 (313) 628-7100 www.ey.com Accountants • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Esperion Therapeutics, Inc. 46701 Commerce Center Drive, Suite B Plymouth, MI 48170 (734) 862-4840 www.esperion.com Pharmaceuticals & Therapeutics

Fraunhofer USA CCL Farnell Equipment Company 2950 Todd Drive Troy, MI 48084 (248) 643-8890 www.farnell-equipment.com Lab Equipment

B100 Eng. Research Complex Michigan State University East Lansing, MI 48824 (517) 432-8711 www.ccl.fraunhofer.org Contract R&D

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Fermical, Inc.

Freeman Manufacturing Company

1360 Hilton Ferndale, MI 48220 (248) 545-1656 Contract R&D, Pharmaceutical & Therapeutics

900 West Chicago Road Sturgis, MI 49091 (616) 651-2371 www.freemanmfg.com Medical Devices

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Essen Instruments 1156 Oak Valley Drive Ann Arbor, MI 48108 (734) 769-1600 www.essen-instruments.com Research Tools, Medical Devices, Contract R&D

Eurofins Avtech Laboratories, Inc. 6859 Quality Way Kalamazoo, MI 49002 (269) 323-3366 www.avtechlabs.com Contract R&D, Diagnostics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Ferndale Laboratories Inc.

900 Victors Way, Suite 1600 Ann Arbor, MI 48108 (734) 994-7394 www.fulcrumpharma.com Contract R&D

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PREFERRED PROVIDER

Field Consulting Services, Inc. 1010 North Wagner Road Ann Arbor, MI 48103 (734) 476-6425 www.fieldconsulting.biz IT Services & Consulting

Exponent, Inc.

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39100 Country Club Drive Farmington Hills, MI 48331 (248) 324-9135 www.exponent.com Medical Devices, Industrial & Environmental, Contract R&D

Field Neuroscience Institute

EXT Lifesciences, Inc. 2000 Town Center, Suite 2370 Southfield, MI 48075 (248) 948-6910 www.extlifesciences.com Pharmaceuticals & Therapeutics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

EyeLab Group

Fulcrum Pharma Developments, Inc.

780 West Eight Mile Road Ferndale, MI 48220 (248) 548-0900 www.ferndalelabs.com Pharmaceuticals & Therapeutics, Contract R&D, Medical Devices, Pharmaceutical

4677 Towne Centre Road, Suite 101 Saginaw, MI 48604 (989) 497-3117 www.fni.org Association/Non-profit

FlowTech Corporation 7601 Stadium Drive Kalamazoo, MI 49009 (269) 375-1290 www.flowtechfilters.com Research Tools, Medical Devices • • • • • • • • • •••••••••••••••••••••••••••

Fullscope, Inc. 1399 Rand Road Canton, MI 48187 (734) 667-1204 www.fullscope.com IT Services & Consulting ••••••••••••••••••••••••••••••••••••

G

GANTEC, Inc. 4520 East Ashman Road, Suite A Midland, MI 48642 (877) 816-9300 www.gantecinc.com Agriculture & Food

Garrison Dental Solutions 1010 DeWitt Lane Spring Lake, MI 49456 (616) 842-2430 www.garrisondental.com Medical Devices

GE Medical Systems Information Technology 3300 Washtenaw Avenue, Suite 225 Ann Arbor, MI 48104 www.gehealthcare.com/usen/hit/index.html Informatics

2350 Washtenaw, Suite 4 Ann Arbor, MI 48104 (734) 665-0567 Medical Devices

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BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

GEMA, LLC 463 Rosewood Avenue East Lansing, MI 48823 (517) 775-3007 Diagnostics

Gene Codes 775 Technology Drive, Suite 100 Ann Arbor, MI 48108 (734) 769-7249 www.genecodes.com Informatics, Research Tools

Gerber Product Company, a Division of Nestlé Nutrition

Global Remediation Technologies Incorporated

445 State Street Fremont, MI 49413 (800) 284-9488 www.gerber.com Agriculture & Food

1102 Cass Street Traverse City, MI 49684 (800) 899-3703 www.grtusa.com Industrial & Environmental, Contract R&D

Gerontology Network 500 Cherry Street SE Grand Rapids, MI 49503 (616) 456-6135 www.michiganseniors.org Association/Non-profit

GeneGo, Inc. 500 Renaissance Drive, Suite 106 St. Joseph, MI 49085 (888) 592-3124 www.genego.com Informatics, Research Tools • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Genemarkers LLC 2718 Oakland Drive Kalamazoo, MI 49008 (269 )998-8116 www.genemarkersllc.com Contract R&D, Diagnostics

Genentech 1 DNA Way South San Francisco, CA 94080 (650) 225-1000 www.gene.com Pharmaceuticals & Therapeutics

Gifford, Krass, Sprinkle, Anderson & Citkowski, PC P.O. Box 7021 Troy, MI 48007 (248) 647-6000 www.patlaw.com Attorneys • • • • • • • • • •••••••••••••••••••••••••••

2203 Platt Road Ann Arbor, MI 48104 (800) 482-4881 www.giftoflifemichigan.org Association/Non-profit

Giri Diagnostics LLC

• •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Genetics Squared, Inc.

GlaxoSmithKline 7890 Charline Court Lewis Center, OH 43035 (740) 549-2426 www.gsk.com Pharmaceuticals & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

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GeneVivo, LLC 800 Technology Drive Ann Arbor, MI 48108 (248) 231-4761 www.genevivo.com Contract R&D

Genomatix Software, Inc. 3025 Boardwalk, Suite 160 Ann Arbor, MI 48108 (877) 436-6628 www.genomatix-software.com Informatics, Contract R&D, Research Tools

BioMatters | Spring 2009

2125 Butterfield Drive, Suite 218N Troy, MI, 48084 (248) 816-6881 www.gsc-llc.com Consulting ••••••••••••••••••••••••••••••••••••

GlyTag LLC 32375 Lahser Road Beverly Hills, MI 48025 (313) 577-9827 www.glytag.com Pharmaceuticals & Therapeutics, Contract R&D, Research Tools

Gift of Life Michigan

2611 Parmenter Boulevard Royal Oak, MI 48073 (248) 435-4472 www.giridiagnostics.com Research Tools, Diagnostics, Contract R&D

401 West Morgan Road Ann Arbor, MI 48104 (734) 929-9475 www.genetics2.com Pharmaceuticals & Therapeutics, Diagnostics, Informatics

Global Strategic Connections, LLC

Global Clinical Connections MTEC at the Groves Kalamazoo Valley Community College 7107 Elm Valley Drive, Suite 2680 Kalamazoo, MI 49009 (269) 488-3277 www.globalclinicalconnections.com Contract R&D • • • • • • • • • •••••••••••••••••••••••••••

GöteborgBio - BRG 3260 Homestead Court Saline, MI 48176 (734) 429-4961 www.goteborgbio.se Government/Economic Development ••••••••••••••••••••••••••••••••••••

Graminex, LLC 95 Midland Road Saginaw, MI 48638 (989) 797-5502 www.graminex.com Agriculture & Food, Pharmaceuticals & Therapeutics

Grand River Aseptic Pharmaceutical Packaging, Inc. Center for Excellence 140 Front Avenue SW, Suite 3 Grand Rapids, MI 49504 (616) 644-0555 www.GrandRiverAPP.com Contract R&D

Grand Valley State University 100CHS 301 Michigan NE Grand Rapids, MI 49503 (616) 331-7192 www.gvsu.edu University/Institution/Hospital ••••••••••••••••••••••••••••••••••••

66

D I R E C TO RY & R E S O U R C E G U I D E

Grant Manufacturing Corporation 10957 Old 27 Highway N. Vanderbilt, MI 49795 (989) 983-3641 www.granthealingenvironment.com Medical Devices

Great Lakes Angels, Inc. 568 Woodway Court, Suite 1 Bloomfield Hills, MI 48302 (248) 540-3758 www.glangels.org Angel Group • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Great Lakes Drug Development, Inc. 1032 Karl Greimel Drive, Suite 11 Brighton, MI 48116 (810) 522-1903 www.gldrugdev.com Contract R&D • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Great Lakes Entrepreneur’s Quest 3520 Green Court, Suite 450 Ann Arbor, MI 48105 (734) 647-8951 www.gleq.org Government/Econ Dev. • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

H

HAC of America, Inc. 1111 West Centre Kalamazoo, MI 49024 (800) 445-9968 www.hacofamerica.com Medical Devices

Hamztec LLC 1039 Olivia Avenue Ann Arbor, MI 48104 (734) 476-8502 Medical Devices

Handy Lab, Inc. 5230 South State Street Ann Arbor, MI 48108 (734) 663-4719 www.handylab.com Research Tools

Harness, Dickey & Pierce, PLC 5445 Corporate Drive, Suite 400 Troy, MI 48098 (248) 641-1600 ext. 1241 www.hdp.com Attorneys • • • • • • • • • •••••••••••••••••••••••••••

Henry Ford Medical Group & Hospital 2799 West Grand Boulevard Detroit, MI 48202 (313) 916-2024 www.Henryford.com University/Institution/Hospital

Hart Enterprises, Inc.

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400 Applejack Court Sparta, MI 49345 (616) 887-0400 www.hartneedles.com Medical Devices, Contract R&D

HistoSonics, LLC

Harvard Drug Company 31778 Enterprise Drive Livonia, MI 48150 (734) 525-8700 www.harvarddrugs.com Pharmaceuticals & Therapeutics

Haviland Enterprises 421 Ann NW Grand Rapids, MI 49504 (800) 456-1134 www.havilandusa.com Agriculture & Food, Industrial & Environmental

HealthCure, LLC 390 Park Street, Suite 110 Birmingham, MI 48009 (248) 282-9300 www.healthcure.biz Diagnostics, Industrial & Environmental, Informatics, Research Tools • • • • • • • • • •••••••••••••••••••••••••••

HealthMedia, Inc. 130 South First Street Ann Arbor, MI 48104 (734) 623-0000 www.healthmedia.com Informatics

Healthtreat, Inc 30777 Northwestern Highway, Suite 300 Farmington Hills, MI 48334 (248) 855-0033 www.healthtreat.com Agriculture & Food

7819 Kilbirnie Drive Portage, MI 49024 (269) 270-4387 Medical Devices ••••••••••••••••••••••••••••••••••••

Honigman Miller Schwartz & Cohn LLP 444 West Michigan Avenue Kalamazoo, MI 49007 (269) 337-7700 www.honigman.com Attorneys ••••••••••••••••••••••••••••••••••••

Horseshoe Herbals 1219 Anderson Road Niles, MI 49120 (269) 684-6888 www.horseherbs.bigstep.com Pharmaceuticals & Therapeutics

Housey Pharmaceutical Research Laboratories, LLC 16800 West 12 Mile Road, Suite 201 Southfield, MI 48076 (248) 663-7000 www.housey.com Pharmaceuticals & Therapeutics ••••••••••••••••••••••••••••••••••••

Hygieia, Inc. 330 East Liberty Street, Lower Level Ann Arbor, MI 48104 (734) 527-9160 www.hygieia.com Medical Devices PREFERRED PROVIDER

Hylant Group 24 Frank Lloyd Wright Drive, Suite J4100 Ann Arbor, MI 48105 (734) 741-0044 www.hylant.com Insurance Provider ••••••••••••••••••••••••••••••••••••

Hanger Prosthetics & Orthodics 2314 Gull Road Kalamazoo, MI 49001 (616) 345-1117 www.hanger.com/Pages/HangerHome.aspx Medical Devices

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BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

I

i3 STATPROBE, Inc. 5430 Data Court, Suite 200 Ann Arbor, MI 48108 (734) 623-8346 www.i3statprobe.com Contract R&D

2175 Lancaster Road, Suite 1 Bloomfield Hills, MI 48302 (248) 425-7992 www.idesign-solutions.info Facilities & Construction

Innovative Research Inc

International Discovery Sourcing Consultants LLC

In the Groove, LLC 7600 Madeline Street Saginaw, MI 48609 (517) 781-6030 www.inthegroovebrace.com Medical Devices

Incept BioSystems 401 West Morgan Road Ann Arbor, MI 48108 (317) 508-6972 www.inceptbio.com Medical Devices, Research Tools

Inland Waters Pollution Control 2021 South Schaefer Highway Detroit, MI 48217 (800) 992-9118 www.inlandwaters.com Industrial & Environmental, Contract R&D

Innovative Analytics Inc. 161 East Michigan Avenue Kalamazoo, MI 49007 (269) 488-3200 www.ianalytics.biz Contract R&D, Informatics

Innovative BioTherapies, Inc.

300 North Main Street, Suite 202 Chelsea, MI 48118 (734) 433-9670 www.idscbiotechnetwork.com Contract R&D ••••••••••••••••••••••••••••••••••••

INRAD, Inc.

220 East Huron Street, 3rd Floor Ann Arbor, MI 48104 (734) 645-8937 www.implantsinternational.com Medical Devices, Pharmaceuticals & Therapeutics, Research Tools

BioMatters | Spring 2009

2529 Dustin Road Okemos, MI 48864 Agriculture & Food, Industrial & Environmental, Research Tools

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401 West Morgan Road Ann Arbor, MI 48108 (734) 213-8350 ext. 301 www.innbio.com Pharmaceuticals & Therapeutics, Medical Devices

Intermediary Biochemicals, LLC

30186 Walnut Court Farmington Hills, MI 48331 (313) 966-7324 Contract R&D

46430 Peary Court Novi, MI 48377 (248) 896-0145 www.innov-research.com Contract R&D, Diagnostics, Research Tools

iDesign Solutions, LLC

Implants International NA

Innovative Cell Technology

4375 Donker Court SE Kentwood, MI 49512 (616) 301-7800 www.inrad-inc.com Medical Devices

Institute for Health Care Studies Michigan State University D 132 West Fee Hall East Lansing, MI 48824 (517) 432-4325 www.ihcs.msu.edu University/Institution/Hospital

Institute for Health Studies 4084 Okemos Road Okemos, MI 48864 (877) 908-2273 www.instituteforhealthstudies.com Universities/Institutions/Hospitals

Institute for Preventive Sports Medicine P.O. Box 7032 Ann Arbor, MI 48107 (734) 572-4577 www.ipsm.org University/Institution/Hospital, Association/Non-profit

Integrated Nonclinical Development Solutions, Inc. 3005 Miller Avenue Ann Arbor, MI 48103 (734) 929-5392 www.INDS-Inc.com Contract R&D, Informatics

Integrated Sensing Systems (ISSYS) 391 Airport Industrial Drive Ypsilanti, MI 48198 (734) 547-9896 www.mems-issys.com Medical Devices, Research Tools

68

International Partnership for Critical Markers of Disease (CMOD) 828 West Grand River Avenue Brighton, MI 48116 (810) 494-7193 www.cmod.org Association/Non-profit

INVIA Medical Imaging Solutions 3025 Boardwalk Street, Suite 200 Ann Arbor, MI 48108 (734) 205-1231 www.inviasolutions.com Informatics, Medical Devices

Invirion, Inc. 2350 Pilgrim Highway Frankfort, MI 49635 (866) 231-8378 www.invirion.com Diagnostics, Research Tools J

J. Rettenmaier, USA 16369 US Highway 131 Schoolcraft, MI 49087 (269) 679-2340 www.jrs.usa.com Agriculture & Food, Industrial & Environmental

Jade Scientific 7855 Ronda Canton, MI 48187 (734) 207-3775 www.jadesci.com Research Tools

D I R E C TO RY & R E S O U R C E G U I D E

Keystone Product Development

K

Jasper Clinical Research & Development, Inc. 526 Jasper Street Kalamazoo, MI 49007 (269) 276-8899 www.jasperclinic.com

5121 East ML Avenue, Suite B-10 Kalamazoo, MI 49048 (269) 746-9141 www.keystone-pd.com Contract R&D, Medical Devices

Kalexsyn, Inc.

Contract R&D

4502 Campus Drive Kalamazoo, MI 49008 (269) 488-8488 www.kalexsyn.com Contract R&D

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KOA Orthopedics

JHP Pharmaceuticals, Inc. 870 Parkedale Road Rochester, MI 48307 (248) 656-5223 www.kingpharm.com Pharmaceuticals & Therapeutics

Jiva Pharma, Inc. 2245 South State Street, Suite 1100 Ann Arbor, MI 48104 (734) 262-0673 Pharmaceuticals & Therapeutics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Johnson & Johnson P.O. Box 726 Langhorne, PA 19047 (517) 648-6767 www.jnj.com Pharmaceuticals& Therapeutics, Medical Devices, Diagnostics, Informatics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Juvenile Diabetes Research Foundation - Metro Detroit & SE Michigan 24359 Northwestern Highway, #225 Southfield, MI 48075 (248) 355-1133 www.jdrfdetroit.org

Juvenile Diabetes Research Foundation - West Michigan 5075 Cascade Road SE, Suite F Grand Rapids. MI 49546 (6160 957-1838 www.jdrf.org/westmichigan Association/Non-profit

JV Biolabs 2245 South State Street Ann Arbor, MI 48104 (734) 395-7436 www.jvbiolabs.com Contract R&D, Research Tools

KAR Bioanalytical, Inc. 4425 Manchester Road Kalamazoo, MI 49001 (269) 381-9666 ext. 232 www.karbio.com Contract R&D • • • • • • • • • •••••••••••••••••••••••••••

46985 Enterprise Drive, Suite A-100 Wixom, MI 48393 (248) 596-0250 www.koaorthopedics Medical Devices

Komodo Pharmaceutical Services, LLC 5121 East ML Avenue Kalamazoo, MI 49048 (269) 567-4260 www.komodops.com Contract R&D

Koppert Biological Systems, Inc. Karmanos Cancer Institute 4100 John R. Detroit, MI 48201 (313) 576-8931 www.karmanos.org University/Institution/Hospital • • • • • • • • • •••••••••••••••••••••••••••

Kellogg Company One Kellogg Square P.O. Box 3599 Battle Creek, MI 49016 (800) 962-1413 www.kelloggcompany.com Agriculture & Food • • • • • • • • • •••••••••••••••••••••••••••

Kendle International 315 East Eisenhower Parkway, Suite 214 Ann Arbor, MI 48108 (734) 274-8500 www.kendle.com Contract R&D

Kestrel Consultants, Inc. 410 Rose Drive Ann Arbor, MI 48103 (734) 576-3031 www.KestrelConsultants.com Contract R&D • • • • • • • • • •••••••••••••••••••••••••••

Keweenaw Nanoscience Center 747 7th Street Calumet, MI 49913 (906) 296-9072 www.nanosciencecenter.com Industrial & Environmental

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2856 South Main Street Ann Arbor, MI 48103 (734) 641-3763 www.agrobiologicals.com/company/C1195.htm Agriculture & Food L

Lake Erie Medical and Surgical 7560 Lewis Avenue Temperance, MI 48182 (734) 847-3847 Medical Devices

Law Offices of Gary Kendra, PC 143 Cady Centre, #319 Northville, MI 48167 (248) 596-1879 www.kendralaw.com Attorneys ••••••••••••••••••••••••••••••••••••

Lead Biopharma Consulting, LLC 7726 Brass Creek Court Dexter, MI 48130 (734) 418-2296 www.leadbiopharma.com Contract R&D ••••••••••••••••••••••••••••••••••••

LEC Tech, Inc. 16647 Chandler Road East Lansing, MI 48823 (517) 332-4610 Agriculture & Food, Industrial & Environmental

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

Maximax International Inc. Lenawee Intermediate School District 4107 North Adrian Highway Adrian, MI 49221 (517) 265-1610 www.lisd.us Education (K-12)

Lynn Medical Instruments

Life Science Systems, Inc.

764 Denison Court P.O. Box 7027 Bloomfield Hills, MI 48302 (248) 338-6242 www.lynnmed.com Medical Devices

784 South Poseyville Road Midland, MI 48640 (989) 698-3067 www.tse-systems.com Contract R&D PREFERRED PROVIDER

Linde LLC

Lindsay Exhibit Group, Inc. 9281 East Michigan State Road 36 Whitmore Lake, MI 48189 (877) 885-7117 www.lindsayexhibits.com Marketing Consulting

29A Riverside Street Nashua, NH 03062 (888) 886-2646 www.mangosoft.com IT Services & Consulting

300 River Place, Suite 6850 Detroit, MI 48207 (313) 446-2800 www.lvadtech.com Medical Devices

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MarketLab PATRON

1514 Eisenhower Place Ann Arbor, MI 48108 (734) 677-1774 www.luminosassays.com Diagnostics, Research Tools

BioMatters | Spring 2009

3985 Research Park Drive Ann Arbor, MI 48108 (734) 930-2043 Research Tools

Mangosoft

L·VAD Technologies, Inc.

35560 Grand River, Suite# 292 Farmington Hills, MI 48335 (800) 374-5270 www.maximax.com Contract R&D

Mayaterials 661 Airport Boulevard., Suite 1 Ann Arbor, MI 48108 (734) 994-7035 www.talmaterials.com Industrial & Environmental

MBI International 3900 Collins Road Lansing, MI 48910 (517) 337-3181 www.mbi.org University/Institutions/Hospitals, Association/Non-profit, Industrial & Environmental

MC3, Inc

PREFERRED PROVIDER

• •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Luminos LLC

Mager Scientific Inc.

Mainline Technologies International

• •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

• •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

M

1100 Baker Road Dexter, MI 48130 (734) 426-8166 www.magersci.com Medical Devices

Linde Midwest Sales Office 2100 Western Court, Suite 100 Lisle, IL 60532 (734) 424-1327 www.lindeus.com Chemicals

22900 West Eight Mile Road Southfield, MI 48033 (248) 351-5600 www.lumigen.com Diagnostics, Research Tools

46701 North Commerce Center Drive, Suite C Plymouth, MI 48170 (734) 233-3060 www.lycera.com Pharmaceuticals & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

• •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Lumigen, Inc.

Lycera Corporation

P.O. Box 888374 Kentwood, MI 49588 (616) 656-2484 www.marketlabinc.com Lab Equipment

MasterControl, Inc. 6322 South 3000 East, Suite 110 Salt Lake City, UT 84121 (801) 631-5381 www.mastercontrol.com IT Services & Consulting • • • • • • • • • •••••••••••••••••••••••••••

70

3550 West Liberty, Suite 3 Ann Arbor, MI 48103 (734) 995-9089 www.mc3corp.com Medical Devices, Contract R&D ••••••••••••••••••••••••••••••••••••

McClinchey Histology Lab, Inc. P.O. Box 421 100 Rice Street Stockbridge, MI 49285 (517) 851-9149 www.mhistolab.com Contract R&D

McKesson Pharmacy Systems 30881 Schoolcraft Livonia, MI 48150 (734) 779-8800 www.mckesson.com Informatics

Mead Johnson Nutritionals, a Division of Bristo Myers Squibb Co 725 East Main Street Zeeland, MI 49464 (812) 429-7795 www.meadjohnson.com Agriculture & Food

MedArray Inc. 3915 Research Park Drive, Suite A-4 Ann Arbor, MI 48108 (734) 769-1066 www.permselect.com Medical Devices, Research Tools

D I R E C TO RY & R E S O U R C E G U I D E

Medtronic Medbio, Inc. 630 South Division Avenue Grand Rapids, MI 49503 (616) 245-0214 www.medbioinc.com Contract R&D • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

MedElute, Inc. 259 East Michigan Avenue, Suite 407 Kalamazoo, MI 49007 (269) 352-3760 Medical Devices

Medical Accessories & Research Corporation 219 North Church Street Zeeland, MI 49464 (616) 748-8950 www.medacc.com Medical Devices, Research Tools

Medical Device Launchpad 34067 Grand River Avenue Farmington, MI 48335 www.medicaldevicelaunchpad.com Contract R&D

620 Watson Street SW Grand Rapids, MI 49504 (616) 242-5200 www.medtronic.com Medical Devices

MemsTech 42503 Steepleview Northville, MI 48167 (7340 560-5506 www.memstech.com Medical Devices, Diagnostics

Merit Laboratories, Inc. 2680 East Lansing Drive East Lansing, MI 48823 (517) 332-0167 www.meritlabs.com Industrial & Environmental, Contract R&D

MERS, LLC 799 Skynob Drive Ann Arbor, MI 48105 (734) 487-1251 www.mersllc.com Medical Devices, Micro and Nano/ Pharmaceuticals & Therapeutics

Medical Imaging Resources, Inc. 120 Enterprise Drive Ann Arbor, MI 48103 (734) 426-3003 www.mobilemedicalimaging.com Medical Devices

MedImage, Inc. 6276 Jackson Road, Suite G Ann Arbor, MI 48103 (734) 665-5400 www.medimage.com Medical Devices, Informatics, Contract R&D

Medi-Nuclear Corp.

30029 Research Drive New Hudson, MI 48165 (800) 423-4226 www.medinuc.com/index.html Medical Devices, Research Tools

Meditrina Pharmaceuticals, Inc. 300 North Fifth Avenue, Suite 150 Ann Arbor, MI 48104 (734) 926-0966 www.meditrinapharma.com Pharmaceuticals & Therapeutics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Metabolic Solutions Development Company 125 South Kalamazoo Mall, #202 Kalamazoo, MI 49007 (616) 464-5071 www.kalmetres.com/index.html Pharmaceuticals & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

MetagenX, LLC 4316 Aztec Way Okemos, MI 48864 (517) 203-0194 Informatics

Michigan Animal Model Consortium - Center for Technology Excellence 333 Bostwick Avenue Grand Rapids, MI 49503 (616) 234-5684 www.ctaalliance.org/cta-cores/michigananimal-model-consortium University/Institution/Hospital, Contract R&D

Michigan Antibody Technology Center - Center of Technology Excellence 333 Bostwick Avenue NE Grand Rapids, MI 49503 (616) 234-5342 www.vai.org/Research/Labs/Antibody Technology.aspx University/Institution/Hospital, Contract R&D, Research Tools

Michigan Association of Health Plans 327 Seymour Avenue Lansing, MI 48933 (517) 371-3181 www.mahp.org Association/Non-profit

Michigan Biological Imaging Center - Center for Technology Excellence Department of Biological Sciences 3425 Woodhall, Western Michigan University Kalamazoo, MI 49008 (269) 387-5640 www.wmich.edu/bios/facilities/imagingcenter/index.html University/Institution/Hospital, Contract R&D

Michigan Biomass Energy Program

3520 Green Court, Suite 450 Ann Arbor, MI 48105 (734) 527-9150 www.michbio.org Association/Non-profit • • • • • • • • • •••••••••••••••••••••••••••

Michigan Agri-Business Association 1501 North Shore Drive, Suite A East Lansing, MI 48823 (517) 332-8663 www.miagbiz.org Association/Non-profit

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611 West Ottawa, P.O. Box 30221 Lansing, MI 48909 (517) 241-6223 www.michigan.gov/biomass Government/Economic Development MEDIA SPONSOR

Michigan Business Review 800 Monroe, Suite 213 Grand Rapids, MI 49503 (616) 222-5784 www.mlive.com/mbusinessreview Media ••••••••••••••••••••••••••••••••••••

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

Michigan Center for Biological Information - Center for Technology Excellence 3600 Green Court, Suite 700 Ann Arbor, MI 48105 (734) 615-5814 www.ctaalliance.org/MCBI University/Institution/Hospital

Michigan Chemistry Council 326 West Ottawa, Capitol Corners Lansing, MI 48933 (517) 372-8898 www.michiganchemistry.com Association/Non-profit

Michigan Citizens for Stem Cell Research and Cures (MCSCRC) 27177 Lahser Road, Suite 102 Southfield, MI 48034 (248) 948-5555 www.StemCellResearchforMichigan.com Association/Non-profit

Michigan Corn Growers Association/Corn Marketing Program of Michigan 12800 Escanaba Drive, Suite B Dewitt, MI 48820 (517) 323-6600 www.micorn.org Association/Non-profit

Michigan Diagnostics LLC 2611 Parmenter Boulevard Royal Oak, MI 48073 (248) 435-4472 www.michdiag.com Contract R&D, Research Tools PLATINUM SPONSOR

Michigan Economic Development Corporation 300 North Washington Square Lansing, MI 48913 (517) 373-9808 www.michiganadvantage.org Government/Economic Development • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Michigan Health & Hospital Association 6215 West St. Joseph Highway Lansing, MI 48917 (517) 323-3443 www.mha.org Association/Non-profit

Michigan Health Council

Michigan Nurses Association

2410 Woodlake Drive, P.O. Box 30014 Okemos, MI 48864 (517) 347-3332 www.mhc.org Association/Non-profit

2310 Jolly Oak Road Okemos, MI 48864 (517) 349-5818 www.minurses.org Association/Non-profit

Michigan High Throughput Screening Center - Center of Technology Excellence

Michigan Orthopedic Services

Kalamazoo Valley Community College 7107 Elm Valley Drive Kalamazoo, MI 49003 (269) 353-1582 www.mhtsc.kvcc.edu University/Institution/Hospital, Contract R&D

Michigan Instruments 717 Talon Court SE Grand Rapids, MI 49512 (616) 554-9696 ext. 305 www.michiganinstruments.com Medical Devices

13450 Farmington Road Livonia, MI 48150 (734) 513-8205 www.michortho.com Medical Devices

Michigan Osteopathic Association 2445 Woodlake Circle Okemos, MI 48864 (517) 347-1555 www.mi-osteopathic.org/index.php Association/Non-profit

Michigan Primary Care Association 7215 Westshire Drive Lansing, MI 48917 (517) 381-8000 www.mpca.net Association/Non-profit

Michigan Israel Business Bridge 3520 Green Court, Suite 450 Ann Arbor, MI 48105 (734) 604-2479 www.michiganisrael.com Association/Non-profit • • • • • • • • • •••••••••••••••••••••••••••

Michigan Research Institute 401 West Morgan Road Ann Arbor, MI 48108 (734) 302-3200 Association/Non-profit ••••••••••••••••••••••••••••••••••••

Michigan Life Ventures, LLC 3605 Tanglewood Drive Ann Arbor, MI 48105 (734) 604-1994 Venture Capital • • • • • • • • • •••••••••••••••••••••••••••

Michigan Medical Dental Association 325 West Lake Lansing Road, Suite C East Lansing, MI 48823 (517) 332-8663 www.smilemichigan.com Association/Non-profit

Michigan Molecular Institute 1910 West Saint Andrews Road Midland, MI 48640 (989) 832-5550 www.mmi.org University/Institution/Hospital, Industrial & Environmental

Michigan Science Teachers Association 3300 Washtenaw Avenue, Suite 220 Ann Arbor, MI 48104 (734) 973-0433 www.msta-mich.org Association/Non-profit

Michigan Small Business & Technology Development Center, Grand Valley State University Seidman College of Business 510 West Fulton Street Grand Rapids, MI 49504 (616) 331-7480 www.misbtdc.org Government/Economic Development ••••••••••••••••••••••••••••••••••••

Michigan Soybean Promotion Committee 140 West Tuscola Street, P.O. Box 287 Frankenmuth, MI 48734 (989) 652-3294 www.michigansoybean.org Association/Non-profit

BioMatters | Spring 2009

72

D I R E C TO RY & R E S O U R C E G U I D E

Michigan State Medical Society 120 West Saginaw East Lansing, MI 48826 (517) 337-1651 www.msms.org Association/Non-profit

Michigan Technology and Research Institute, LLC

Michigan State University Michigan Center for Structural Biology - Center for Technology Excellence Department of Biochemistry 310 A Biochemistry East Lansing, MI 48824 (517) 355-0199 www.mcsb.bch.msu.edu University/Institution/Hospital

Michigan State University MSU Technologies 301 Administration Building East Lansing, MI 48824 (517) 355-5040 www.cga.msu.edu University/Institution/Hospital SILVER SPONSOR

Michigan State University Office of Research & Graduate Studies 120 West Saginaw East Lansing, MI 48826 (517) 337-1651 www.vprgs.msu.edu University/Institution/Hospital • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

2245 South State Street, Suite 1100 Ann Arbor, MI 48104 (734) 222-0013 www.MTRInstitute.com Contract R&D

80 Agriculture Hall East Lansing, MI 48824 (517) 432-1676 www.productcenter.msu.edu University/Institution/Hospital • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Michigan Technological University Office of Technology and Economic Development 1400 Townsend Drive, Harold Meese Building Houghton, MI 49931 (888) 688-1885 www.admin.mtu.edu/iptc University/Institution/Hospital • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

4717 Campus Drive Kalamazoo, MI 49008 (269) 372-3758 www.micromyx.com Contract R&D, Research Tools ••••••••••••••••••••••••••••••••••••

• • • • • • • • • •••••••••••••••••••••••••••

Michigan Universities Commercialization Initiative (MUCI) 3003 South State Street, Wolverine Tower Room 2071 Ann Arbor, MI 48109 (734) 647-5730 www.muci.org University/Institution/Hospital • • • • • • • • • •••••••••••••••••••••••••••

Michigan Venture Capital Association 425 North Main Street Ann Arbor, MI 48104 (734) 223-3750 www.michiganvca.org Association/Non-profit

Micro Machine Co. 2429 North Burdick Street Kalamazoo, MI 49007 (616) 388-2440 www.micromachineco.com Contract R&D, Medical Devices

Microbiological Associates, Inc. Michigan State University Product Center for Agriculture and Natural Resources

Micromyx, LLC

37428 Hills Tech Drive Farmington Hills, MI 48331 (248) 324-4800 www.microbioassociates.com Contract R&D, Agriculture & Food, Diagnostics

Microcide, Inc. 2209 Niagara Drive Troy, MI 48083 (888) 342-6279 www.microcideinc.com.com Agriculture & Food

MicroDose Life Sciences, LLC

37935 West12 Mile Road, Building 1, Suite A Farmington Hills, MI 48331 (248) 489-1190 www.micro-dose.com Venture Capital

Midbrook, Inc.

2080 Brooklyn Road Jackson, MI 49203 (517) 787-3481 www.midbrook.com Contract R&D, Medical Devices ••••••••••••••••••••••••••••••••••••

MidMichigan Innovation Center 4520 East Ashman Road, Suite M Midland, MI 48642 (989) 839-2333 www.mmic.us Government/Econ Dev.

Midwest Cleanroom Associates, Inc.

2055 Oak Industrial Drive, Suite A Grand Rapids, MI 49505 (616) 458-8533 www.mcacleanrooms.com Facilities & Construction ••••••••••••••••••••••••••••••••••••

Miller, Canfield, Paddock & Stone, PLC 840 West Long Lake Road, Suite 200 Troy, MI 48098 (313) 963-6420 www.millercanfield.com Attorneys ••••••••••••••••••••••••••••••••••••

MIR Preclinical Services a Charles River Company 800 Technology Drive Ann Arbor, MI 48108 (734) 821-1063 www.molecularimaging.com Contract R&D, Diagnostics

MMS Holdings Inc. 6880 Commerce Boulevard Canton, MI 48187 (734) 245-0310 www.mmsholdings.com Contract R&D

• • • • • • • • • •••••••••••••••••••••••••••

73

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

Molecular Innovations Inc. 21315 Hilltop Street Southfield, MI 48034 (248) 353-4900 ext. 10 www.mol-innov.com Research Tools, Contract R&D • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Molecular Therapeutics, Inc. 800 Technology Drive, Suite 100 Ann Arbor, MI 48108 (734) 222-9900 www.moleculartherapeutics.com Pharmaceuticals & Therapeutics

Monal, Inc./Monal Labs 23611 Liberty Street Farmington, MI 48335 (248) 474-4557 www.MonalLabs.com Facilities & Construction • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

PREFERRED PROVIDER

Monitor Liability Managers Inc. 2850 West Golf Road, Suite 800 Rolling Meadows, IL 60008 (800) 446-2100 www.monitorliability.com Insurance Provider • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Monteris Medical, Inc. 4664 Campus Drive Kalamazoo, MI 49008 (269) 372-0455 www.monteris.com/index.htm Medical Devices

Motion Resources, Stryker Orthopedic 9487 Holly Road Grand Blanc, MI 48439 (810) 714-5500 www.stryker.com/en-us/products/Orthopaedics/index.htm Medical Devices

Mt. Clemens Orthopaedic Appliances, Inc. 24432 Crocker Boulevard Clinton Township, MI 48036 (586) 463-3600 Medical Devices

MuciMed, Inc. 259 East Michigan Avenue, Suite 409 Kalamazoo, MI 49007 (906) 842-3212 Pharmaceuticals & Therapeutics

M-Vision 12420 Stanley Drive Belleville, MI 48111 (734) 697-3933 www.m-visioninc.com Medical Devices

Mycol Balm Laboratories, Inc. 9595 Raucholz Road St. Charles, MI 48655 (989) 585-3357 www.mycolbalm.com Pharmaceuticals & Therapeutics

National Center for Manufacturing Sciences 3025 Boardwalk Ann Arbor, MI 48108 (800) 222-6267 www.ncms.org Association/Non-profit ••••••••••••••••••••••••••••••••••••

National Kidney Foundation of Michigan 1169 Oak Valley Drive Ann Arbor, MI 48108 (734) 222-9800 www.nkfm.org Association/Non-profit

Natural Therapeutics, LLC 401 West Morgan Road Ann Arbor, MI 48108 (734) 302-3200 www.fungalnailrelief.com/PrivacyPolicy.asp Pharmaceuticals & Therapeutics PREFERRED PROVIDER

N

Nature Publishing Group

NanoBio Corporation 2311 Green Road, Suite A Ann Arbor, MI 48105 (734) 302-4000 www.nanobio.com Pharmaceuticals & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

Nanoderm Therapeutics, Inc. 3081 North Foxridge Court Ann Arbor, MI 48105 (734) 665-4105 Pharmaceuticals & Therapeutics

NanoMed Pharmaceuticals, Inc. 7107 Elm Valley Drive, Room B1210 Kalamazoo, MI 49009 (269) 488-8525 www.nanomedpharm.com Contract R&D, Pharmaceutical & Therapeutics, Research Tools

75 Varick St., 9th Floor New York, NY 10013-1917 (212) 726-9760 www.nature.com Publisher ••••••••••••••••••••••••••••••••••••

Neocutis 11910 Fox Ridge Drive Plymouth, MI 48170 (734) 207-5104 www.neocutis.com Pharmaceuticals & Therapeutics

Neogen Corporation 620 Lesher Place Lansing, MI 48912 (800) 234-5333 www.neogen.com Agriculture & Food, Diagnostics, Research Tools, Pharmaceuticals & Therapeutics ••••••••••••••••••••••••••••••••••••

• • • • • • • • • •••••••••••••••••••••••••••

MPI Research 54943 North Main Street Mattawan, MI 49071 (269) 668-3336 www.mpiresearch.com Contract R&D

NanoVir LLC 4717 Campus Drive, Suite 1300 Kalamazoo, MI 49008 (269) 372-3261 www.nanovirpharm.com Pharmaceuticals & Therapeutics

• •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Nephrion, Inc. 401 West Morgan Road Ann Arbor, MI 48108 (734) 272-4772 www.nephrion.com Medical Devices, Diagnostics ••••••••••••••••••••••••••••••••••••

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D I R E C TO RY & R E S O U R C E G U I D E

NephRx Corporation 4717 Campus Drive, Suite 100 Kalamazoo, MI 49008 (269) 372-8703 www.nephrxcorp.com Pharmaceuticals & Therapeutics

NeuroNexus Technologies 3985 Research Park Drive, Suite 100 Ann Arbor, MI 48108 (734) 913-8858 www.neuralnexustech.com Medical Devices

Northern Biomedical Research, Inc.

PREFERRED PROVIDER

Office Depot

930 West Sherman Boulevard Muskegon, MI 49441 (231) 759-2333 Contract R&D

800 Eisenhower Parkway Ann Arbor, MI 48106 (734) 259-9281 www.officedepot.com Office Furniture, Supplier

Northwest OrthoticsProsthetic, Inc.

•••••••••••••••••••••••••••••••••••••

39830 Grand River, Suite BLD Novi, MI 48375 (248) 477-1443 Medical Devices

O’Mara Products 3025 Sangra Avenue Grandville, MI 49118 (616) 531-9500 www.omaraproductsinc.com Lab Equipment

Norwind-Cortez Newport Consulting Group 7286 North Village Drive Clarkston, MI 48346 (248) 978-2000 www.newportconsgroup.com/index.html IT Services & Consulting • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Next Generation Therapeutics, Inc. 2900 Huron Parkway, Suite 8 Ann Arbor, MI 48105 (734) 527-9139 www.nextgenerationtherapeutics.com/ default.aspx Contract R&D, Industrial & Environmental, Medical Devices, Pharmaceuticals & Therapeutics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

NEXT Mobility 7444 Haggerty Road Canton, MI 48187 (888) 489-6398 www.nextmobilitynow.com Medical Devices • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

NextGen Sciences, Inc. 4401 Varsity Drive, Suite E Ann Arbor, MI 48108 (734) 973-7914 ext. 214 www.nextgensciences.com Contract R&D, Diagnostics, Research Tools

Nitrate Elimination Company, Inc. 334 Hecla Street Lake Linden, MI 49945 (906) 296-1000 www.nitrate.com Research Tools

305 North Hewitt Ypsilanti, MI 48197 (734) 434-0575 Medical Devices

••••••••••••••••••••••••••••••••••••

NuStep

Omega Surgical Instruments, Inc.

5111 Venture Drive, Suite 1 Ann Arbor, MI 48108 (734) 769-3939 www.nustep.com Medical Devices

G-8395 South Saginaw Street Grand Blanc, MI 48439 (800) 656-6342 www.omegasurgical.com Medical Devices

Nymirum 117 North First Street Ann Arbor, MI 48105 (734) 604-9597 Pharmaceuticals & Therapeutics O

Oakland County Planning & Economic Development 1200 Pontiac Lake Road, Building 41W Waterford, MI 48328 (248) 858-9099 www.globaloakland.com Government/Economic Development • • • • • • • • • •••••••••••••••••••••••••••

GOLD SPONSOR

Oakland University 520 Dowd Hall Rochester, MI 48309 (248) 370-2100 www.oakland.edu University/Institution/Hospital • • • • • • • • • •••••••••••••••••••••••••••

Ophthigenics LLC 2900 Huron Parkway, Suite 4 Ann Arbor, MI 48105 (734) 945-5408 www.ophthigenics.com Contract R&D

Optical Dimensions 711 East 4th Street Royal Oak, MI 48067 (248) 541-3790 www.opticaldimensionslab.com/default.aspx Medical Devices

Optical Supply 1526 Plainfield Avenue, NE Grand Rapids, MI 49505 (616) 361-6000 www.optical-supply.com Contract R&D, Medical Devices

Optim 30963 Woodward Avenue Royal Oak, MI 48073 (248) 551-0549 www.optimvalue.com Informatics

Orchard Unique OcuSciences, Inc. 3201 Asher Road Ann Arbor, MI 48104 (734) 646-4156 www.ocusciences.com Diagnostics

6688 Dixie Highway Bridgeport, MI 48722 (989) 746-0780 www.orchid-orthopedics.com/unique Contract R&D

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BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E

Orchid Orthopedic Solutions, LLC

Paragon Laboratories, Inc.

1489 Cedar Street Holt, MI 48842 (517) 694-2300 www.macdeeinc.com Contract R&D, Medical Devices

12649 Richfield Court Livonia, MI 48150 (734) 462-3900 www.paragonlaboratories.com Contract R&D

PharmMor Consulting, LLC P.O. Box 2570 Portage, MI 49081 (269) 327-2215 Contract R&D

PBS Biotech Originus, Inc. 3985 Research Park Drive Ann Arbor, MI 48108 (734) 913-8791 www.originusinc.com Contract R&D, Research Tools • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Orthopedic Development, Inc. 1400 Low Road Kalamazoo, MI 49008 (269) 544-4715 Industrial & Environmental, Medical Devices

OtoMedicine, Inc. 576 Romence Road, Suite 227 Portage, MI 49024 (269) 321-0265 www.otomedicine.com Agriculture & Food • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Oxford Biomedical Research, Inc. 2165 Avon Industrial Drive Rochester Hills, MI 48309 (248) 852-8815 www.oxfordbiomed.com Contract R&D, Research Tools • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

P

Painex Corporation 18295 James Couzens Highway Detroit, MI 48235 (313) 863-1200 www.ringmasternow.com/index.html Pharmaceuticals & Therapeutics

Pall Corporation - Life Sciences 600 South Wagner Road Ann Arbor, MI 48103 (800) 521-3160 www.pall.com Research Tools, Medical Devices

••••••••••••••••••••••••••••••••••••

2529 Dustin Road Okemos, MI 48864 www.pbsbiotech.com Research Tools

PharmOptima, LLC

Perrigo Company 515 Eastern Avenue Allegan, MI 49010 (269) 673-8451 www.perrigo.com Pharmaceuticals & Therapeutics, Contract R&D GOLD SPONSOR

Pfizer Inc. 7000 Portage Road Kalamazoo, MI 49001 (269) 833-4000 www.pfizer.com Pharmaceuticals & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

Phadia US 4169 Commercial Avenue Portage, MI 49002 (800) 346-4364 www.phadia.us Diagnostics, Research Tools

Pharmacision LLC

6710 Quality Way Portage, MI 49002 (269) 329-4370 www.pharmoptima.com Contract R&D ••••••••••••••••••••••••••••••••••••

Phillips Plastics Corporation 30230 Orchard Lake Road, Suite 150 Farmington Hills, MI 48334 (248) 851-8300 www.phillipsplastic.com Contract R&D

Phrixus Pharmaceuticals, Inc. 300 North Fifth Avenue, Suite 150 Ann Arbor, MI 48104 (734) 358-9015 www.phrixuspharmaceuticals.com Pharmaceuticals & Therapeutics ••••••••••••••••••••••••••••••••••••

GOLD SPONSOR

PhRMA (Pharmaceutical Research and Manufacturers of America)

1947 Mistwood Court Canton, MI 48187 (734) 895-3670 www.pharmacision.com Contract R&D

950 F Street, NW, Suite 300 Washington, DC 20004 (202) 835-3400 www.phrma.org Association/Non-profit

• • • • • • • • • •••••••••••••••••••••••••••

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PhycoTech PharmaMed Resources, LLC 790 Crosswind Lane Lindenhurst, IL 60046 (269) 303-0798 www.pharmamedresources.com Contract R&D • • • • • • • • • •••••••••••••••••••••••••••

620 Broad Street, Suite 100 St. Joseph, MI 49085 (616) 983-3654 www.phycotech.com Contract R&D, Research Tools

Pinnacle Insurance Partners 1430 Monroe NW, Suite 100 Grand Rapids, MI 49505 (800) 746-4253 ext. 126 www.pinnacleinsurancepartners.com Insurance Provider ••••••••••••••••••••••••••••••••••••

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Pioneer Surgical Technology

Precision Edge Surgical Products

375 River Park Circle Marquette, MI 49855 (906) 226-9909 www.pioneersurgical.com Medical Devices

415 West 12th Avenue Sault Sainte Marie, MI 49783 (906) 632-4800 www.precisionedge.com Medical Devices

Pixel Velocity Inc.

Price, Heneveld, Cooper, DeWitt & Litton

3917 Research Park Drive, Suite B7 Ann Arbor, MI 48108 (734) 213-3715 ext. 4200 www.pixel-velocity.com Medical Devices • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

695 Kenmoor SE Grand Rapids, MI 49501 (616) 949-9610 www.priceheneveld.com Attorneys • • • • • • • • • •••••••••••••••••••••••••••

Proteos, Inc. 4717 Campus Drive Kalamazoo, MI 49008 (269) 372-3423 www.proteos.net Industrial & Environmental, Diagnostics, Contract R&D, Research Tools ••••••••••••••••••••••••••••••••••••

Protomatic 2125 Bishop Circle West Dexter, MI 48130 (734) 426-3655 www.protomatic.com Manufacturer

Progressive Dynamics Medical

Plas-Labs, Inc.

507 Industrial Road Marshall, MI 49068 (269) 781-4241 www.progressivedynamicsmedical.com Medical Devices

401 East North Street Lansing, MI 48906 (517) 372-7177 www.plas-labs.com Contract R&D • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

ProNAi Therapeutics, Inc. Plex Systems, Inc. 1731 Harmon Road Auburn Hills, MI 48326 (248) 391-8000 www.plex.com IT Services & Consulting

4717 Campus Drive, Suite 1100 Kalamazoo, MI 49008 (269) 372-3289 www.pronai.com Pharmaceuticals & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

ProPharma Group

5449 Research Drive Canton, MI 48188 (800) 445-9853 ext. 109 www.pointescientific.com Research Tools

8175 Creekside Drive Portage, MI 49024 (888) 242-0559 www.propharmagroup.com Consulting

POLY Bioinformatics

• • • • • • • • • •••••••••••••••••••••••••••

12191 East Austin Road Manchester, MI 48158 (734) 678-7342 www.polyergic.com Informatics

Pros-Tech 1717 Stephenson Highway Troy, MI 48083 (248) 680-2800 www.prostechctr.com Medical Devices

PREFERRED PROVIDER

PR Newswire LLC 101 West Big Beaver Road, Floor 14 Troy, MI 48084 (734) 337-3401 www.prnewswire.com Media

50900 Corporate Drive Macomb, MI 48044 (586) 263-5100 www.teampti.com Manufacturer, Plastics ••••••••••••••••••••••••••••••••••••

PVS Chemicals, Inc. 10900 Harper Avenue Detroit, MI 48213 (313) 921-1200 www.pvschemicals.com Industrial & Environmental Q

• • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Pointe Scientific, Inc.

PTI Engineered Plastics, Inc.

Prosthetic Center, Inc. 1200 South Washington Avenue Lansing, MI 48910 (517) 372-7007 Medical Devices

Quality Care Products 7560 Lewis Avenue Temperance, MI 48182 (734) 847-3847 ext. 260 www.qcpmeds.com Pharmaceuticals & Therapeutics

Quantum Laboratories 28221 Beck Road, Suite A-11 Wixom, MI 48393 (248) 348-7029 www.quantumlaboratories.com Contract R&D

QuatRx Pharmaceuticals 777 East Eisenhower Parkway, Suite 100 Ann Arbor, MI 48108 (734) 913-9900 www.quatrx.com Pharmaceutical & Therapeutics ••••••••••••••••••••••••••••••••••••

• • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Quest Diagnostics Incorporated 4444 Giddings Road Auburn Hills, MI 48326 Diagnostics, Contract R&D

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Quest Research Institute 31000 Telegraph, Suite 230 Bingham Farms, MI 48025 (248) 644-7770 www.questri.com Contract R&D • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

R

RADAR Medical Systems LLC 6632 Telegraph Road, Suite 333 Bloomfield Hills, MI 48301 (248) 626-9012 www.radarmed.com Informatics

Rader, Fishman & Grauer PLLC 39533 Woodward Avenue, Suite 140 Bloomfield Hills, MI 48304 (248) 594-0600 www.raderfishman.com Attorneys • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Rapid BioSense 3900 Collins Road Lansing, MI 48910 (800) 579-4913 www.rapidbiosense.com Diagnostics, Medical Devices

Regulatory Affairs Associates, LLC 30833 Northwestern Highway, Suite 121 Farmington Hills, MI 48334 (248) 855-5595 www.regaffairs.net Contract R&D • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

RG Medical Diagnostics 28351 Beck Road, Suite G5 Wixom, MI 48393 (888) 596-9498 www.rgmd.com Medical Devices

Richard-Allan Scientific 4481 Campus Drive Kalamazoo, MI 49008 (616) 644-2400 www.rallansci.com Research Tools

Rigaku Innovative Technologies

Rubicon Genomics, Inc.

1900 Taylor Road Auburn Hills, MI 48326 (248) 232-6400 www.rigaku.com Research Tools, Medical Devices

4370 Varsity Drive, Suite G Ann Arbor, MI 48108 (734) 677-6210 www.rubicongenomics.com Diagnostics, Contract R&D, Research Tools

Riverside Organics

RxDispense, Inc.

8100 Linden Detroit, MI 48238 (313) 933-0510 Contract R&D, Industrial & Environmental

2706 Cumberland Berkley, MI 48072 (734) 277-0668 www.rxdispense.com Medical Devices

RJL Systems, Inc. 33939 Harper Avenue Clinton Township, MI 48035 (586) 790-0200 ext. 103 www.rjlsystems.com Medical Devices, Research Tools • • • • • • • • • •••••••••••••••••••••••••••

S

S & J Laboratories 4669 Executive Drive Portage, MI 49002 (269) 324-7383 www.sandjlab.com/index.html Contract R&D

Roche Biomedical Labs 32355 Capitol Street Livonia, MI 48150 (734) 525-0248 Contract R&D, Diagnostics

Rockwell Medical Technologies, Inc. 30142 Wixom Road Wixom, MI 48393 (800) 449-3353 www.rockwellmed.com Medical Devices, Research Tools

Rose Technologies 1440 Front Avenue NW Grand Rapids, MI 49504 (616) 233-3000 www.rose-technologies.com Contract R&D

Roush Life Sciences 12068 Market Street Livonia, MI 48150 (734) 779-7752 www.roush.com Contract R&D, Medical Devices, Research Tools • • • • • • • • • •••••••••••••••••••••••••••

RTI Health Solutions 3005 Boardwalk Street, Suite 105 Ann Arbor, MI 48108 (734) 213-5372 www.rtihs.org Contract R&D

Saline Lectronics, Inc. 710 North Maple Road Saline, MI 48176 (734) 944-2120 www.lectronics.net Manufacturer, Electronics ••••••••••••••••••••••••••••••••••••

SANDAB Group P.O. Box 2472 Birmingham, MI 48012 (248) 644-0011 www.sandab.com Contract R&D SUPPORTER

sanofi-aventis US 55 Corporate Drive Bridgewater, NJ 08807 (636) 273-5409 www.sanofi-aventis.us/live/us/en/index.jsp Pharmaceutical & Therapeutics ••••••••••••••••••••••••••••••••••••

ScarPrev Pharmaceuticals 917 Packard Street Ann Arbor, MI 48104 (734) 717-9263 Pharmaceutical & Therapeutics PREFERRED PROVIDER

Science Direct 3675 Crestwood Parkway, Suite 400 Duluth, GA 30096 (770) 935-6077 www.elsevier.com Information Services Provider ••••••••••••••••••••••••••••••••••••

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SciTech Development LLC 281 Kercheval Road Grosse Pointe Farms, MI 48236 (313) 576-8263 www.scitechdevelopment.com Medical Devices, Pharmaceuticals & Therapeutics • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

ScreenTrack 1603 Peach Street Ann Arbor, MI 48105 (734) 665-0701 Informatics

Secretory IgA Inc. 333 Parkland Plaza Drive Ann Arbor, MI 48104 (734) 994-0966 www.secretoryiga.com Pharmaceuticals & Therapeutics

Selective Technologies, Inc. 132 West First Street Flint, MI 48502 (810) 767-7530 Medical Devices

Sensound 221 Lewiston Road Grosse Pointe Farms, MI 48236 (313) 882-1065 www.sensound.com Medical Devices

Sentry Medical Technologies 1039 Olivia Avenue Ann Arbor, MI 48104 (734) 476-8502 Informatics

Sequenom Center for Molecular Medicine 301 Michigan Street NE, Suite 580 Grand Rapids, MI 49503 (616) 391-4330 www.cmmdx.org Diagnostics, Research Tools

Shanghai Bio Corporation 21792 Cumberland Drive Northville, MI 48167 (248) 787-2757 www.ShanghaiBio.com Contract R&D • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Shrader Analytical and Consulting Laboratories, Inc. 3814 Vinewood Detroit, MI 48208 (313) 894-4440 www.shraderlabs.com Contract R&D

Siemens Ultrasound Division 400 West Morgan Ann Arbor, MI 48108 (734) 995-5010 www.usa.siemens.com/entry/ en/?tab=healthcare Medical Devices

Signal Medical Corporation 400 Pyramid Marysville, MI 48040 (810) 364-7070 www.signalmd.com Medical Devices

SOI HR Solutions

58 Parkland Plaza, Suite 200 Ann Arbor, MI 48103 (734) 904-5611 www.soistaff.com/hr Human Resources ••••••••••••••••••••••••••••••••••••

SoloHill Engineering, Inc. 4370 Varsity Drive, Suite B Ann Arbor, MI 48108 (734) 973-2956 www.solohill.com Research Tools, Medical Devices

Somanetics Corporation 1653 East Maple Road Troy, MI 48083 (248) 689-3050 www.somanetics.com Medical Devices

Sonetics Ultrasound, Inc. Single Source Procurement, LLC

3550 West Liberty, Suite 3 Ann Arbor, MI 48103 (734) 260-4800 Medical Devices

• • • • • • • • • •••••••••••••••••••••••••••

Southwest Michigan First

Skyline Property Group, Inc.

241 East Michigan Avenue Kalamazoo, MI 49024 (269) 553-9588 www.southwestmichiganfirst.com Government/Economic Development

6852 South 6th Street Kalamazoo, MI 49009 (269) 372-3997 www.sspusa.com Procurement Services

2146 Livernois Troy, MI 48083 (248) 680-9900 ext. 212 Facilities & Construction

••••••••••••••••••••••••••••••••••••

• • • • • • • • • •••••••••••••••••••••••••••

Skytron 5085 Corporate Exchange Boulevard Grand Rapids, MI, 49512 (800) 759-8766 www.skytron.us Medical Devices

Slaughter Instrument Co. 4356 North Roosevelt Road Stevensville, MI 49127 (269) 428-7471 www.slaughtercoinc.com Medical Devices

Smith Haughey Rice & Roegge 213 South Ashley, Suite 400 Ann Arbor, MI 48104 (734) 213-8000 www.shrr.com Attorneys

Southwest Michigan Innovation Center 4717 Campus Drive, Suite 100 Kalamazoo, MI 49008 (269) 353-1823 www.kazoosmic.com Government/Economic Development ••••••••••••••••••••••••••••••••••••

Sparton Medical Supply 2400 East Ganson Street Jackson, MI 49202 (517) 787-8600 www.spartonmedicalsystems.com/index.htm Medical Devices, Contract R&D

SPI Pharma P.O. Box 226 Grand Haven, MI 49417 (231) 935-6900 www.spipharma.com Contract R&D

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SSV Therapeutics, LLC 2245 South State Street, Suite 1100 Ann Arbor, MI 48104 (734) 262-0673 Pharmaceuticals & Therapeutics

Sterling Diagnostics 36645 Metro Court Sterling Heights, MI 48312 (810) 979-9171 www.sterlingdiagnostics.com Research Tools, Diagnostics

Stryker Corporation 2825 Airview Boulevard Kalamazoo, MI 49002 (269) 385-2600 www.stryker.com Medical Devices

Stryker Instruments 4100 East Milham Avenue Kalamazoo, MI 49001 (269) 323-7700 www.stryker.com/instruments Medical Devices

Stryker Orthopaedics 44736 Helm Street Plymouth, MI 48170 (734) 454-0023 www.stryker.com/en-us/corporate/ContactUs/ Orthopaedics/index.htm Medical Devices

SubTerra LLC P.O. Box 55 104 Wilcox Road White Pine, MI 49971 (906) 885-5953 www.subterrallc.com Agriculture & Food, Contract R&D

Surge Medical Solutions 3710 Sysco Court SE Grand Rapids, MI 49512 (616) 949-2392 www.surgemedical.com Medical Devices

Surgitel 77 Enterprise Drive Ann Arbor, MI 48103 (734) 996-9200 www.surgitel.com Medical Devices

PREFERRED PROVIDER

Switchback

Team Pharmaceutical Inc.

300 North Fifth, Suite 120 Ann Arbor, MI 48104 (734) 418-8348 www.switchbackcms.com IT Services & Consulting

563 116th Avenue Martin, MI 49070 (269) 388-5708 Pharmaceuticals & Therapeutics

Symmetry Jet 5212 Aurelius Road Lansing, MI 48911 (517) 882-4311 www.symmetrymedical.com Medical Devices

Tech Initiatives Inc. 200 Michigan Street, Suite 408 Hancock, MI 49930 (906) 483-2676 www.cprmattress.com Contract R&D ••••••••••••••••••••••••••••••••••••

Synergy Group, Inc. 39400 Woodward Avenue, Suite 190 Bloomfield Hills, MI 48304 (248) 740-7400 www.synergygroup.biz/index.htm Facilities & Construction • • • • • • • • • •••••••••••••••••••••••••••

Systems Specialties 390 Enterprise Court, Suite 200 Bloomfield Hills, MI 48302 (248) 332-0099 www.sysspec.com Research Tools T

Takeda Pharmaceuticals North America, Inc. One Takeda Parkway Deerfield, IL 60015 (715) 246-9930 www.tpna.com Pharmaceuticals & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

TCF National Bank 301 North Main Street, Suite 100 Ann Arbor, MI 48104 (734) 669-5531 www.tcfbank.com Banking • • • • • • • • • •••••••••••••••••••••••••••

TCH Pharmaceuticals, Inc. 300 North Fifth Avenue, Suite 150 Ann Arbor, MI 48104 (734) 926-0966 Pharmaceuticals & Therapeutics • • • • • • • • • •••••••••••••••••••••••••••

BioMatters | Spring 2009

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TechTown 440 Burroughs, Entrepreneurial Suite Detroit, MI 48202 (313) 879-5250 www.techtownwsu.org/index.htm Government/Economic Development ••••••••••••••••••••••••••••••••••••

TEDCo - Technology Enterprise Development Co., Inc. 3301 South Dort Highway, Suite 200 Flint, MI 48433 (734) 945-8789 www.tedcoinc.com Consulting ••••••••••••••••••••••••••••••••••••

Teresa M. Arnold & Associates 8300 Adler Road Lambertville, MI 48144 (734) 854-1187 www.tmaapr.com Marketing Consulting ••••••••••••••••••••••••••••••••••••

TERRE Clinical Research Services, Inc. 323 North First Street Ann Arbor, MI 48103 (734) 623-6454 www.terrecrs.com Contract R&D

D I R E C TO RY & R E S O U R C E G U I D E

Thomson Healthcare Terumo Cardiovascular Systems Corp.

6200 Jackson Road Ann Arbor, MI 48103 (800) 521-2818 www.terumo-us.com Medical Devices, Research Tools • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

Terumo Heart, Inc. 6180 Jackson Road Ann Arbor, MI 48103 (734) 741-6114 www.terumoheart.com Medical Devices

The Dow Chemical Company

2030 Dow Center Midland, MI 48674 (800) 258-2436 www.dowventurecapital.com Industrial & Environmental, Agriculture & Food • • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

The MRI Insititute for Biomedical Research Imaging 440 East Ferry Street, Unit 2 Detroit, MI 48202 (313) 758-0065 www.mrimaging.com University/Institution/Hospital

The Point Services 1515 Chimney Ridge Traverse City, MI 49686 (231) 366-4121 www.thepointservcies.com Staffing and Recruiting

777 East Eisenhower Parkway Ann Arbor, MI 48108 (734) 913-3000 www.medstat.com Informatics 7755 Narrow Gauge Road Beulah, MI 49617 (231) 882-4672 www.thornsmithlabs.com Research Tools

Threefold Sensors, LLC P.O. Box 1306 Ann Arbor, MI 48106 (734) 995-9338 www.threefoldsensors.com Diagnostics, Medical Devices

TransPharm Preclinical Solutions, LLC 7190 Brooklyn Road Jackson, MI 49201 (517) 536-8210 www.transpharmsite.com Contract R&D ••••••••••••••••••••••••••••••••••••

Trialon Corporation

Thromgen 803 North Main Street Ann Arbor, MI 48104 (216) 368-1172 www.thromgen.com Pharmaceuticals & Therapeutics

5600 New King Street, Suite 345 Troy, MI 48098 (248) 205-2510 www.trialon.com Staffing and Recruiting

Thumb Oilseed Producers

••••••••••••••••••••••••••••••••••••

2145 Leppek Road Ubly, MI 48475 (989) 658-2344 www.thumboilseed.com Agriculture & Food

Trilithon Pharma, LLC

Tolera Therapeutics, Inc.

330 East Maple Troy, MI 48083 (248) 733-1030 www.troypolymers.com Contract R&D

4717 Campus Drive Kalamazoo, MI 49008 (800) 695-1554 www.tolerainc.com Pharmaceutical & Therapeutics

Topspins, Inc.

MI (734) 637-3490 Pharmaceuticals & Therapeutics

Troy Polymers

TSRL, Inc.

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The Right Place, Inc.

Torrey Path LLC

161 Ottawa Avenue NW, Suite 400 Grand Rapids, MI 49503 (616) 771-0325 www.rightplace.org Government/Economic Development

255 East Liberty Street, Suite 273 Ann Arbor, MI 48104 (734) 418-8356 www.metamaticsllc.com Informatics

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Tower Laboratories

10170 East Cherry Bend Road Traverse City, MI 49684 (313) 922-0177 www.thompsonsurgical.com Medical Devices

P.O. Box 27482 Lansing, MI 48909 www.txisllc.com Contract R&D, Informatics

Thorn Smith Laboratories

403 Riverview Drive Ann Arbor, MI 48104 (734) 623-6400 www.topspins.com Medical Devices

Thompson Surgical Instruments

Toxicogenomic Informatics and Solutions, LLC

8060 Whitbeck Road Montague, MI 49437 (231) 893-1472 www.towerlabs.com Contract R&D

81

540 Avis Drive, Suite A Ann Arbor, MI 48108 (734) 663-4233 www.tsrlinc.com Contract R&D ••••••••••••••••••••••••••••••••••••

Twin Bay Medical, Inc. 11590 South US-31 Williamsburg, MI 49690 (231) 935-4370 www.barblock.com Medical Devices

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D I R E C TO RY & R E S O U R C E G U I D E

U

Uckele Health and Nutrition P.O. Box 160 Blissfield, MI 49228 (800) 248-0330 www.uckele.com Agriculture & Food, Contract R&D

Ultralight Prosthetics, Inc.

SILVER SPONSOR

University of Michigan Life Sciences Institute

University of Michigan – Office of Vice President for Research

210 Washtenaw Avenue Ann Arbor, MI 48109 (734) 763-1200 www.lsi.umich.edu University/Institution/Hospital

4080 Fleming Building 503 Thompson Ann Arbor, MI 48109-1340 (734) 764-1185 www.research.umich.edu University/Institution/Hospital

24781 Five Mile Road Redford, MI 48239 (313) 538-8500 www.ultralightprostetics.com Medical Devices

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Ultrasound Medical Devices, Inc.

24 Frank Lloyd Wright Drive, Lobby M, Suite 2600 Ann Arbor, MI 48106 (734) 998-6994 www.med.umich.edu/ummic University/Institution/Hospital

3917 Research Park, Suite B-7 Ann Arbor, MI 48108 (734) 369-5056 Medical Devices

Unival, Inc. 2100 Commonwealth Boulevard, Suite 300 Ann Arbor, MI 48105 (800) 332-4463 www.unival-med.com Informatics

United BioSource Corporation 2200 Commonwealth Boulevard, Suite 100 Ann Arbor, MI 48105 (734) 994-8940 www.unitedbiosource.com Contract R&D

University of Michigan Biomedical Engineering 2200 Bonisteel Boulevard Ann Arbor, MI 48109 (734) 647-9926 www.bme.umich.edu University/Institution/Hospital • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

University of Michigan Coulter Translational Research Partnership Program University of Michigan Department of Biomedical Engineering 2200 Bonisteel Boulevard, 1131 Gerstacker Building Ann Arbor, MI 48109 (734) 615-9412 www.bme.umich.edu/research/coulter.php University/Institution/Hospital • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

••••••••••••••••••••••••••••••••••••

University of Michigan Medical Innovation Center

• • • • • • • • • •••••••••••••••••••••••••••

University of Michigan Michigan Center for Oral Health 1011 North University, Room 3228 Ann Arbor, MI 48109 (734) 647-4622 www.dent.umich.edu/research/clinicalresearch University/Institution/Hospital

University of Michigan Michigan Institute for Clinical Health Research 24 Frank Lloyd Wright Drive, Lobby M Ann Arbor, MI 48106 (734) 998-7474 www.michr.umich.edu University/Institution/Hospital

University of Michigan Michigan Nanotechnology Institute for Medicine and Biological Sciences 1150 West Medical Center Drive, SPC 5648, 9220C MSRB III Ann Arbor, MI 48109 (734) 647-2777 www.nano.med.umich.edu University/Institution/Hospital

University of Michigan – Michigan Proteome Consortium Center for Technology Excellence 300 North Ingalls Building, 11th Floor, Room 1198 Ann Arbor MI, 48109 (734) 763-3130 www.proteomeconsortium.org University/Institution/Hospital, Contract R&D

University of Michigan Technology Transfer Office 1214 South University, 2nd Floor Ann Arbor, MI 48104 (734) 763-0614 www.techtransfer.umich.edu University/Institution/Hospital ••••••••••••••••••••••••••••••••••••

V

Van Andel Institute 333 Bostwick Avenue NE Grand Rapids, MI 49503 (616) 234-5000 www.vai.org University/Institution/Hospital ••••••••••••••••••••••••••••••••••••

BRONZE SPONSOR

Varnum, Riddering, Schmidt & Howlett Bridgewater Place, 333 Bridge Street NW Grand Rapids, MI 49501 (616) 336-6000 www.varnumlaw.com Attorneys ••••••••••••••••••••••••••••••••••••

Velcura Therapeutics, Inc. 4300 Varsity Drive, Suite D Ann Arbor, MI 48108 (734) 973-1000 www.velcura.com Pharmaceutical & Therapeutics ••••••••••••••••••••••••••••••••••••

Velesco Pharma Services 3221 Heather Road Ann Arbor, MI 48108 (734) 545-0696 www.velescopharma.com Contract R&D ••••••••••••••••••••••••••••••••••••

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D I R E C TO RY & R E S O U R C E G U I D E

Welch Laboratories, Inc.

W

4270 Sunnyside Drive Holland, MI 49424 (616) 399-2711 www.welchlaboratories.com Contract R&D

W.F. Valentine & Co.

VenOmix, Inc. 4717 Campus Drive, Suite 1200 Kalamazoo, MI 49008 (616) 889-9611 www.venomix.net Agriculture & Food, Industrial & Environmental, Pharmaceuticals & Therapeutics

7633 Quackenbush Reading, MI 49274 (517) 283-3143 www.horseshoes.com Pharmaceutical & Therapeutics

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3301 Sutton Road Adrian, MI 49221 (517) 264-8793 www.wacker.com Industrial & Environmental, Agriculture & Food

Versus Technology, Incorporated 2600 Miller Creek Drive Traverse City, MI 49684 (231) 946-5868 www.versustech.com Informatics

West Michigan Regional Laboratory

Wacker Chemical Corporation

SUPPORTER

West Michigan Science and Technology Initiative

Warde Medical Laboratory

Vertellus Health and Specialty Products, LLC 215 North Centennial Street Zeeland, MI 49464 (800) 223-0453 www.vertellus.com Contract R&D, Industrial & Environmental

300 West Textile Road Ann Arbor, MI 48108 (734) 214-0300 www.wardelab.com Contract R&D, Diagnostics

Warner Norcross & Judd LLP

VetGen, LLC 3728 Plaza Drive, Suite 1 Ann Arbor, MI 48108 (734) 669-8440 www.vetgen.com Contract R&D, Diagnostics

Vigor Equipment, Inc. 4915 Advance Way Stevenville, MI 49127 (269) 429-0191 www.vigorequipment.com Medical Devices

Virotech Co., Inc. 34279 Hazelwood Street Westland, MI 48186 (734) 620-0221 www.virotech-inc.com Pharmaceuticals & Therapeutics

Vortech Pharmaceuticals 6851 Chase Road Dearborn, MI 48126 (313) 584-4088 www.vortechpharm.com Pharmaceuticals & Therapeutics PREFERRED PROVIDER

VWR International 1668 Chapleau Drive Ann Arbor, MI 48103 (800) 932-5000 www.vwr.com Lab Equipment

900 Fifth Third Center 111 Lyon St NW, Suite 900 Grand Rapids, MI 49503 (616) 752-2000 www.wnj.com Attorneys

301 Michigan Street NE, Suite 537 Cook - DeVos Center for Health Sciences Grand Valley State University Grand Rapids, MI 49503 (616) 331-5840 www.wmsti.org Government/Economic Development ••••••••••••••••••••••••••••••••••••

Western Slope Laboratory 1197 Rochester Road, Suite K Troy, MI 48083 (248) 307-1168 www.westernslopelabs.com/index.shtml Contract R&D

• • • • • • • • • •••••••••••••••••••••••••••

FRIEND

Wayne State University Technology Commercialization 5057 Woodward Avenue, Suite 6306 Detroit, MI 48202 (313) 577-5541 www.techtransfer.wayne.edu University/Institution/Hospital • • • • • • • • • •••••••••••••••••••••••••••

Wayne State University Applied Genomic Technologies - Center for Technology Excellence WSU-5197, Biological Science Building 5047 Gullen Mall Detroit, MI 48202 (313) 577-3555 www.bioinformatics.wayne.edu/MCGT University/Institution/Hospital, Association/Non-profit, Industrial & Environmental

1726 Knollcrest Circle SE Grand Rapids, MI 49546 (616) 526-8440 www.calvin.edu/admin/wmrl Contract R&D

Williams Syndrome Association P.O. Box 297 Clawson, MI 48017 (248) 244-2229 www.williams-syndrome.org Association/Non-profit

Wise BioStrategies LLC 820 Heatherway Ann Arbor, MI 48104 (734) 904-4489 Consulting ••••••••••••••••••••••••••••••••••••

Working Bugs, LLC 16647 Chandler Road East Lansing, MI 48823 (517) 974-3030 www.workingbugs.com Contract R&D, Industrial & Environmental

• • •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • • •

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X

XB TransMed Solutions, LLC 3133 Orchard Vista Drive SE Grand Rapids, MI 49546 (616) 234-5586 www.xbtransmed.com Informatics, Contract R&D

XG Sciences, Inc. 5020 Northwind Drive, Suite 212 East Lansing, MI 48823 (517) 203-1110 www.xgsciences.com Industrial & Environmental, Research Tools

Xoran Technologies, Inc. 309 North First Street Ann Arbor, MI 48103 (734) 663-7194 www.xorantech.com Medical Devices, Diagnostics • •• •• •• •• •• •• •• •• •• •• •• •• • • • • • • • • • • •

Y

YourSurgery.com 7171 First Street West Bloomfield, MI 48324 (248) 334-2568 www.yoursurgery.com/Index.cfm Informatics Z

zuSyn 4717 Campus Drive, Suite 100 Kalamazoo, MI 49008 (312) 997-2150 www.zusyn.com Pharmaceutical & Therapeutics

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D I R E C TO RY & R E S O U R C E G U I D E L isting b y category

Key to Listings by Category Accountants............................................... 86 Agriculture & Food Bio-Based Technologies & Products............ 86 Biochemicals............................................... 86 BioFuels....................................................... 86 BioPlastics................................................... 86 Biotechnology & GMOs............................... 86 Feed Stock.................................................... 86 Food Products............................................. 86 Food Safety.................................................. 86 Forestry....................................................... 86 Nutrition & Nutriceuticals........................... 86 Plant-Based Therapeutics........................... 86 Architects................................................... 86 Association/Non-Profit Educational.................................................. 86 Government Affairs..................................... 86 Medical........................................................ 87 Attorneys.................................................... 87 Banks.......................................................... 87 Business Development.............................. 87 Business Funding...................................... 87 Consulting.................................................. 87 Contract R&D Analytical.................................................... 87 Animal Models/Transgenics........................ 87 Chemistry.................................................... 87 Clinical Trial Development.......................... 88 Commercialization/Business Support......... 88 Drug Development & Formulation.............. 88 Informatics.................................................. 88 Manufacturing/Production......................... 88 Market Research & Strategy........................ 89 Pharmacology.............................................. 89 Project Management.................................... 89 Prototype Development & Testing............... 89 Regulatory & Compliance............................ 89 Research & Technologies............................. 90 Safety & Toxicology..................................... 90 Structural Biology & Drug Design............... 90

Financial Consultants............................... 91

Medical Devices Dental.......................................................... 93 Diagnostics.................................................. 93 Hospital Equipment & Furnishings............. 94 Lab Tools & Instruments............................. 94 Medical Imaging.......................................... 94 Prosthetics & Orthotics............................... 94 Safety........................................................... 94 Sensors........................................................ 95 Surgical........................................................ 95 Therapeutic................................................. 95

Freezer & Refrigeration Services............. 91

Office Furniture......................................... 95

Government Affairs................................... 91

Pharmaceuticals & Therapeutics Animal Health............................................. 95 Biologics & Biosimilars............................... 95 Cell-Based Therapies & Regenerative Medicine................................ 96 Generics....................................................... 96 Natural Products......................................... 96 Nutriceuticals & Alternative Medicines....... 96 OTC.............................................................. 96 Synthetic Small Molecule............................ 96 Vaccines....................................................... 96

Biosensors................................................... 91 Genetic Testing & Index Arrays................... 91 Imaging & Scans.......................................... 91 Molecular..................................................... 91 Electronics................................................. 91 Employee Benefits..................................... 91 Engineering Services................................ 91 Facilities & Construction......................... 91 Filter Media................................................ 91

Government/Economic Development Business Development & Planning............. 91 Incubators................................................... 91 Small Business Assistance........................... 92 Human Resources..................................... 92 Industrial & Environmental Bio-Defense................................................. 92 Bio-Plastics.................................................. 92 Chemicals.................................................... 92 Environmental Cleanup............................... 92 Enzymes...................................................... 92 Fermentation............................................... 92 Nanotechnologies & Products..................... 92 White Biotechnology................................... 92 Informatics Bio & Chem.................................................. 92 Data Capture & Management...................... 92 Development................................................ 93 Enterprise Management.............................. 93 Healthcare & Wellness................................. 93 LIMS............................................................ 93 Research...................................................... 93 Information Services Provider................ 93 Information Technology Services & Consulting............................... 93 Insurance Providers.................................. 93 Lab Equipment.......................................... 93

Creative Services....................................... 90

Manufacturing Support............................ 93

Diagnostics Biochemical/Protein/Antibody................... 90 Biomarkers.................................................. 90

Marketing Consultants............................. 93 Media.......................................................... 93

Procurement Services............................... 96 Public Relations......................................... 96 Real Estate.................................................. 96 Research Tools Instruments & Equipment.......................... 96 Lab Furnishings........................................... 97 Reagents & Materials................................... 97 Testing & Kits.............................................. 97 Software...................................................... 97 Staffing & Recruiting................................ 97 Strategy/Planning..................................... 97 Supplier...................................................... 97 Technical Writing...................................... 97 University/Institution/Hospital Academic/Education................................... 98 Clinical/Hospital.......................................... 98 Contract Work.............................................. 98 Private.......................................................... 98 Public........................................................... 98 Research...................................................... 99 Tech Transfer............................................... 99 Venture & Angel Capital............................ 99

85

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y category Accountants

Agriculture & Food - Feed Stock

Doeren Mayhew Ernst & Young LLP

Bayer CropScience Draths Industries, LLC J. Rettenmaier, USA The Dow Chemical Company Uckele Health and Nutrition

Agriculture & Food - Bio-Based Technologies & Products Agrium Bayer CropScience Caltech Industries, Inc. Diversified Natural Products Draths Industries, LLC EcoSynthetix Emerald BioAgriculture Corporation / Auxein Corporation GANTEC, Inc. Graminex, LLC Intermediary Biochemicals, LLC J. Rettenmaier, USA Koppert Biological Systems, Inc. LEC Tech, Inc. Neogen Corporation The Dow Chemical Company VenOmix, Inc.

Agriculture & Food Biochemicals Bayer CropScience Burdick & Jackson Diversified Natural Products Emerald BioAgriculture Corporation / Auxein Corporation GANTEC, Inc. Haviland Enterprises Intermediary Biochemicals, LLC LEC Tech, Inc. The Dow Chemical Company VenOmix, Inc. Wacker Chemical Corporation

Agriculture & Food - BioFuels The Dow Chemical Company

Agriculture & Food - BioPlastics EcoSynthetix J. Rettenmaier, USA

Agriculture & Food Biotechnology & GMOs Bayer CropScience Emerald BioAgriculture Corporation / Auxein Corporation GANTEC, Inc. VenOmix, Inc.

BioMatters | Spring 2009

Agriculture & Food - Food Products Cerise Nutraceuticals, Inc. Gerber Product Company Graminex, LLC Healthtreat, Inc Kellogg Company Mead Johnson Nutritionals Thumb Oilseed Producers Uckele Health and Nutrition

Agriculture & Food - Food Safety Microbiological Associates, Inc. Microcide, Inc. Neogen Corporation Thumb Oilseed Producers Uckele Health and Nutrition

Agriculture & Food - Forestry J. Rettenmaier, USA

Agriculture & Food - Nutrition & Nutriceuticals Cerise Nutraceuticals, Inc. Diversified Natural Products Ecology Health Products, Inc. Gerber Product Company Graminex, LLC Haviland Enterprises Healthtreat, Inc Kellogg Company Mead Johnson Nutritionals Uckele Health and Nutrition

Agriculture & Food - Plant Based Therapeutics SubTerra LLC

Architects CRB Consulting Engineers iDesign Solutions, LLC Midwest Cleanroom Associates, Inc.

Association/Non-Profit Educational American Diabetes Association American Society for Microbiology American Society of Employers Cascade Hemophilia Consortium

86

Clinical Ligand Assay Society Field Neuroscience Institute Gerontology Network Gift of Life Michigan Institute for Health Studies International Partnership for Critical Markers of Disease (CMOD) Juvenile Diabetes Research Foundation Metro Detroit & SE Michigan Juvenile Diabetes Research Foundation West Michigan MichBio Michigan Agri-Business Association Michigan Association of Health Plans Michigan Chemistry Council Michigan Citizens for Stem Cell Research and Cures (MCSCRC) Michigan Corn Growers Association/Corn Marketing Program of Michigan Michigan Health & Hospital Association Michigan Health Council Michigan Israel Business Bridge Michigan Medical Dental Association Michigan Nurses Association Michigan Osteopathic Association Michigan Primary Care Association Michigan Science Teachers Association Michigan Soybean Promotion Committee Michigan State Medical Society Michigan Venture Capital Association National Kidney Foundation of Michigan PhRMA (Pharmaceutical Research and Manufacturers of Americas) Williams Syndrome Association

Association/Non-Profit Government Affairs American Society of Employers Canadian Consulate General MichBio Michigan Agri-Business Association Michigan Association of Health Plans Michigan Corn Growers Association/Corn Marketing Program of Michigan Michigan Health & Hospital Association Michigan Health Council Michigan Medical Dental Association Michigan Nurses Association Michigan Osteopathic Association Michigan Primary Care Association Michigan Soybean Promotion Committee Michigan State Medical Society Michigan Venture Capital Association PhRMA (Pharmaceutical Research and Manufacturers of America)

D I R E C TO RY & R E S O U R C E G U I D E

Associations/Non-Profit Medical American Diabetes Association Cascade Hemophilia Consortium Clinical Ligand Assay Society ClinXus Field Neuroscience Institute Gerontology Network Gift of Life Michigan Institute for Health Studies International Partnership for Critical Markers of Disease (CMOD) Juvenile Diabetes Research Foundation - Metro Detroit & SE Michigan Juvenile Diabetes Research Foundation - West Michigan Michigan Association of Health Plans Michigan Health & Hospital Association Michigan Health Council Michigan Medical Dental Association Michigan Nurses Association Michigan Osteopathic Association Michigan Primary Care Association Michigan State Medical Society National Kidney Foundation of Michigan PhRMA (Pharmaceutical Research and Manufacturers of America) Williams Syndrome Association

Attorneys Brinks, Hofer, Gilson & Lione Brooks Kushman Butzel Long Dykema, PLLC Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C. Harness, Dickey & Pierce, P.L.C. Honigman Miller Schwartz and Cohn LLP Law Offices of Gary Kendra, PC Miller, Canfield, Paddock & Stone, P.L.C. Price, Heneveld, Cooper, DeWitt & Litton Rader, Fishman & Grauer PLLC Smith Haughey Rice & Roegge Varnum, Riddering, Schmidt & Howlett Warner Norcross & Judd LLP

Banks Bank of Ann Arbor TCF National Bank

Business Development AP Bio-Consulting LLC Apjohn Group, LLC Aptuit Consulting, Inc Biotechnology Business Consultants (BBC) Collet Consulting, LLC

Field Consulting Services, Inc. Global Strategic Connections, LLC Michigan Biomass Energy Program Michigan Life Ventures, LLC Michigan Small Business & Technology Development Center Southwest Michigan Innovation Center TEDCo - Technology Enterprise Development Co., Inc. Wise BioStrategies LLC

Business Funding Ann Arbor SPARK Automation Alley Biosciences Research and Commercialization Center - Center for Technology Excellence Great Lakes Entrepreneur’s Quest Michigan Economic Development Corporation Southwest Michigan First Southwest Michigan Innovation Center TechTown West Michigan Science and Technology Initiative

Consulting AP Bio-Consulting LLC Apjohn Group, LLC Aptuit Consulting, Inc Beaumont Services Company LLC Biotechnology Business Consultants (BBC) Caladium Consulting Collet Consulting, LLC Der-Balian Inc Eliason Consulting Global Strategic Connections, LLC National Center for Manufacturing Sciences PharmaMed Resources, LLC ProPharma Group SOI HR Solutions TEDCo - Technology Enterprise Development Co., Inc. Wise BioStrategies LLC

Contract R&D - Analytical AAPharmaSyn LLC Absolute Analytical, Inc AEGIS Environments Antel BioSystems, Inc AzoRx, Inc. Bio-Chem Laboratories, Inc. DBA Analytical (an NSF International Company) Eurofins Avtech Laboratories, Inc. Ferndale Laboratories Inc. Giri Diagnostics LLC

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Global Remediation Technologies Incorporated KAR Bioanalytical, Inc. MPI Research NextGen Sciences, Inc. Paragon Laboratories, Inc. PharmOptima, LLC PhycoTech Plas-Labs, Inc. Quantum Laboratories Roche Biomedical Labs S & J Laboratories Shanghai Bio Corporation Shrader Analytical and Consulting Laboratories, Inc. SPI Pharma TSRL, Inc. Velesco Pharma Services Warde Medical Laboratory Western Slope Laboratory

Contract R&D - Animal Models/ Transgenics Arbor Preclinical & Consulting, LLC Charles River GeneVivo, LLC Innovative Research Inc. JV Biolabs Michigan Animal Model Consortium - Center for Technology Excellence MIR Preclinical Services (a Charles River Company) MPI Research Northern Biomedical Research, Inc. PharmOptima, LLC TransPharm Preclinical Solutions, LLC TSRL, Inc. West Michigan Regional Laboratory

Contract R&D - Chemistry AAPharmaSyn LLC Albemarle Corporation Alluvium Biosciences, Inc. AzoRx, Inc. Bio-Chem Laboratories, Inc. Boro Pharm, LLC Bridge Organics Co. DBA Analytical (an NSF International Company) Draths Industries, LLC Fermical, Inc. Giri Diagnostics LLC Grand River Aseptic Pharmaceutical Packaging, Inc. Kalexsyn, Inc. Next Generation Therapeutics, Inc. Plas-Labs, Inc.

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y category Contract R&D - Chemistry continued...

Riverside Organics Shrader Analytical and Consulting Laboratories, Inc. Vortech Pharmaceuticals Welch Laboratories, Inc.

Contract R&D - Clinical Trial Development Ann Arbor Clinical Research AzoRx, Inc. Beaumont Hospitals BioPharma Data Services BioSTAT Consultants, Inc. Borgess Research Institute ClinSite, Inc. ClinXus Exponent, Inc. Ferndale Laboratories Inc. Fulcrum Pharma Developments, Inc. Henry Ford Health System Great Lakes Drug Development, Inc. i3 STATPROBE, Inc. Innovative Analytics Inc. Institute for Health Studies International Discovery Sourcing Consultants LLC Jasper Clinical Research & Development, Inc. KAR Bioanalytical, Inc. Karmanos Cancer Institute Kendle International Kestrel Consultants, Inc. Maximax International Inc. MMS Holdings Inc. Quest Research Institute RTI Health Solutions TERRE Clinical Research Services, Inc. United BioSource Corporation University of Michigan - Michigan Institute for Clinical Health Research

Contract R&D - Commercialization/Business Support Beaumont Commercialization Center Biosciences Research of Commercialization Center - Center for Technology Excellence MC3, Inc. Medical Device Launchpad Pharmicision, LLC PharmMor Consulting, LLC SANDAB Group Tech Initiatives Inc.

BioMatters | Spring 2009

Contract R&D - Drug Development & Formulation Access Business Group ADMETRx Arbor Preclinical & Consulting, LLC AzoRx, Inc. BioSTAT Consultants, Inc. CeeTox, Inc. Charles River Corium International, Inc. Eurofins Avtech Laboratories, Inc. Fulcrum Pharma Developments, Inc. Global Clinical Connections Innovative Analytics Inc. Innovative Cell Technology Integrated Nonclinical Development Solutions, Inc. International Discovery Sourcing Consultants LLC Jasper Clinical Research & Development, Inc. Kendle International Komodo Pharmaceutical Services, LLC McClinchey Histology Lab, Inc. Michigan Technology and Research Institute, LLC MMS Holdings Inc. MPI Research NanoMed Pharmaceuticals, Inc. Next Generation Therapeutics, Inc. Northern Biomedical Research, Inc. Perrigo Company PharmOptima, LLC S & J Laboratories Shanghai Bio Corporation SPI Pharma TERRE Clinical Research Services, Inc. TSRL, Inc. Velesco Pharma Services

Contract R&D - Informatics AIS Consulting Altarum Arbor Research Collaborative for Health Arivium, Inc. BioPharm Data Services BlueWare, Inc. Compendia Bioscience Critech Research, Inc. DNA Software, Inc. Genomatix Software, Inc. Integrated Nonclinical Development Solutions, Inc. Toxicogenomic Informatics and Solutions, LLC XB TransMed Solutions, LLC

88

Contract R&D - Manufacturing/ Production

Access Business Group AEGIS Environments Albemarle Corporation Alluvium Biosciences, Inc. Ash Stevens ATEK Medical Manufacturing Avalon Laboratories LLC Boro Pharm, LLC Bridge Organics Co. CFI Medical Solutions (Contour Fabricators, Inc.) Corium International, Inc. Creative Technology Services Di-Coat Corp Doctor’s Orders, Inc Draths Industries, LLC DuPeron Medical Systems Ferndale Laboratories Inc. Fraunhofer USA CCL Grand River Aseptic Pharmaceutical Packaging, Inc. - Center for Technology Excellence Hart Enterprises Kalexsyn, Inc. Keystone Product Development Komodo Pharmaceutical Services, LLC Medbio, Inc. Michigan Animal Model Consortium Center for Technology Excellence Micro Machine Co. Midbrook, Inc. Next Generation Therapeutics, Inc. Optical Supply Orchard Unique Orchid Orthopedic Solutions, LLC Oxford Biomedical Research, Inc. Perrigo Company Phillips Plastics Corporation Plas-Labs, Inc. Proteos, Inc. Protomatic Riverside Organics Rose Technologies Roush Life Sciences Saline Lectronics, Inc. Sparton Medical Systems SPI Pharma SubTerra LLC Tower Laboratories Montague Troy Polymers Uckele Health and Nutrition Vertellus Health and Specialty Products, LLC Vortech Pharmaceuticals Welch Laboratories, Inc. Working Bugs, LLC

D I R E C TO RY & R E S O U R C E G U I D E

Contract R&D - Market Research & Strategy AzoRx, Inc. DNADNB LLC International Discovery Sourcing Consultants LLC Keystone Product Development Lead Biopharma Consulting, LLC Medical Device Launchpad Pharmacision LLC SANDAB Group

Contract R&D - Pharmacology Arbor Preclinical & Consulting, LLC AzoRx, Inc. BioSTAT Consultants, Inc. CeeTox, Inc. Charles River Innovative Analytics Inc. Integrated Nonclinical Development Solutions, Inc. International Discovery Sourcing Consultants LLC JV Biolabs KAR Bioanalytical, Inc. Kendle International Lead Biopharma Consulting, LLC Micromyx, LLC MIR Preclinical Services (a Charles River Company) MPI Research Northern Biomedical Research, Inc. PharmOptima, LLC TransPharm Preclinical Solutions, LLC West Michigan Regional Laboratory

Contract R&D - Project Management AIS Consulting AP Bio-Consulting LLC Aptuit Consulting, Inc Arbor Research Collaborative for Health Arivium, Inc. AzoRx, Inc. Beaumont Commercialization Center Biotechnology Business Consultants (BBC) Caladium Consulting Collet Consulting, LLC Critech Research, Inc. CSM Group Fulcrum Pharma Developments, Inc. Global Clinical Connections Global Strategic Connections, LLC Great Lakes Drug Development, Inc.

i3 STATPROBE, Inc. Inland Waters Pollution Control Innovative Analytics Inc. Integrated Nonclinical Development Solutions, Inc. International Discovery Sourcing Consultants LLC Kestrel Consultants, Inc. Lead Biopharma Consulting, LLC Maximax International Inc. MC3, Inc. Medical Device Launchpad Michigan Technology and Research Institute, LLC Midwest Cleanroom Associates, Inc. Monal, Inc./Monal Labs MPI Research Newport Consulting Group Orchard Unique Pharmacision LLC PharmMor Consulting, LLC ProPharma Group RTI Health Solutions TEDCo - Technology Enterprise Development Co., Inc. TERRE Clinical Research Services, Inc. United BioSource Corporation Wise BioStrategies LLC

Contract R&D - Prototype Development & Testing ATEK Medical Manufacturing Avalon Laboratories LLC Beaumont Commercialization Center Beaumont Services Company LLC Creative Technology Services Doctor’s Orders, Inc. DuPeron Medical Systems Exponent, Inc. Fraunhofer USA CCL Hart Enterprises Keystone Product Development MC3, Inc. Medbio, Inc. Micro Machine Co. Orchard Unique Orchid Orthopedic Solutions, LLC Phillips Plastics Corporation Protomatic Rose Technologies Roush Life Sciences Saline Lectronics, Inc. Sparton Medical Systems Troy Polymers

89

Contract R&D - Regulatory & Compliance Access Business Group AIS Consulting Ann Arbor Clinical Research Aptuit Consulting, Inc. AzoRx, Inc. Beaumont Commercialization Center BioPharma Data Services BioSTAT Consultants, Inc. Caladium Consulting CeeTox, Inc. Charles River DBA Analytical (an NSF International Company) DuPeron Medical Systems Eurofins Avtech Laboratories, Inc. Exponent, Inc. Fulcrum Pharma Developments, Inc. Global Clinical Connections Great Lakes Drug Development, Inc. i3 STATPROBE, Inc. Innovative Analytics Inc. Integrated Nonclinical Development Solutions, Inc. International Discovery Sourcing Consultants LLC Jasper Clinical Research & Development, Inc. KAR Bioanalytical, Inc. Kendle International Kestrel Consultants, Inc. Keystone Product Development Komodo Pharmaceutical Services, LLC Lead Biopharma Consulting, LLC MasterControl, Inc. Maximax International Inc. Medical Device Launchpad Michigan Technology and Research Institute, LLC Micromyx, LLC MMS Holdings Inc. MPI Research Newport Consulting Group Orchard Unique Pathology Experts, LLC PharmaMed Resources, LLC PharmMor Consulting, LLC PharmOptima, LLC ProPharma Group Regulatory Affairs Associates, LLC RTI Health Solutions SOI HR Solutions Sparton Medical Systems TERRE Clinical Research Services, Inc. TransPharm Preclinical Solutions, LLC United BioSource Corporation

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y category Contract R&D - Research & Technologies Absolute Analytical, Inc. AIS Consulting Antel BioSystems, Inc. ApoLife, Inc. AquaBiochip, LLC Arbor Preclinical & Consulting, LLC Asterand, Inc. AzoRx, Inc. Biodiscovery, LLC Biotech Clinical Laboratories Cell Culture Characterization Services Charles River Cutting Image Histology, LLC Essen Instruments Fermical, Inc. Fraunhofer USA CCL Genemarkers LLC Giri Diagnostics LLC GlyTag LLC Innovative Research Inc. Lead Biopharma Consulting, LLC Merit Laboratories, Inc. Michigan Antibody Technology Center - Center of Technology Excellence Michigan Diagnostics LLC Michigan High Throughput Screening Center Center of Technology Excellence Micromyx, LLC MIR Preclinical Services (a Charles River Company) Molecular Innovations Inc. MPI Research NanoMed Pharmaceuticals, Inc. NextGen Sciences, Inc. Northern Biomedical Research, Inc. Ophthigenics LLC Originus, Inc. Paragon Laboratories, Inc. PharmOptima, LLC PhycoTech Roche Biomedical Labs Rubicon Genomics, Inc. Shanghai Bio Corporation Shrader Analytical and Consulting Laboratories, Inc. Toxicogenomic Informatics and Solutions, LLC TransPharm Preclinical Solutions, LLC Troy Polymers TSRL, Inc. VetGen, LLC Warde Medical Laboratory West Michigan Regional Laboratory Western Slope Laboratory Working Bugs, LLC

BioMatters | Spring 2009

Contract R&D - Safety & Toxicology Absolute Analytical, Inc. ADMETRx AEGIS Environments Ann Arbor Clinical Research Antel BioSystems, Inc. AquaBiochip, LLC Arbor Preclinical & Consulting, LLC AzoRx, Inc. Bio-Chem Laboratories, Inc. BioSTAT Consultants, Inc. Biotech Clinical Laboratories CeeTox, Inc. Charles River Crissman Toxicologic Pathology, LLC Cutting Image Histology, LLC DBA Analytical (an NSF International Company) Drug & Laboratory Disposal, Inc. Eurofins Avtech Laboratories, Inc. Exponent, Inc. Fermical, Inc. Fulcrum Pharma Developments, Inc. Global Remediation Technologies Incorporated Inland Waters Pollution Control Innovative Analytics Inc. Integrated Nonclinical Development Solutions, Inc. International Discovery Sourcing Consultants LLC Jasper Clinical Research & Development, Inc. JV Biolabs KAR Bioanalytical, Inc. Kendle International McClinchey Histology Lab, Inc. Merit Laboratories, Inc. Michigan Biological Imaging Center - Center for Technology Excellence Michigan Technology and Research Institute, LLC Microbiological Associates, Inc. Micromyx, LLC MIR Preclinical Services (Molecular Imaging Research) MPI Research Northern Biomedical Research, Inc. Paragon Laboratories, Inc. Pathology Experts, LLC PharmOptima, LLC PhycoTech Quantum Laboratories Roche Biomedical Labs S & J Laboratories Shanghai Bio Corporation TERRE Clinical Research Services, Inc.

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Toxicogenomic Informatics and Solutions, LLC TransPharm Preclinical Solutions, LLC Warde Medical Laboratory Western Slope Laboratory

Contract R&D - Structural Biology & Drug Design AAPharmaSyn LLC DNA Software, Inc. Michigan Center for Structural Biology Center for Technology Excellence

Creative Services Global Strategic Connections, LLC Lindsay Exhibit Group, Inc. Teresa M. Arnold & Associates

Diagnostics - Biochemical/ Protein/Antibody Antel BioSystems, Inc. Armune BioScience, Inc. Assay Designs, Inc. Becton Dickinson - Difco Laboratories Biomedical Diagnostics, LLC Biotech Clinical Laboratories Cayman Chemical Company Cell Culture Characterization Services Cutting Image Histology, LLC Detroit R & D, Inc. Eurofins Avtech Laboratories, Inc. Giri Diagnostics LLC HealthCure, LLC Neogen Corporation Oxford Biomedical Research, Inc. Phadia US Proteos, Inc. Quest Diagnostics Incorporated Roche Biomedical Labs Sterling Diagnostics Threefold Sensors, LLC Virotech Co., Inc. Warde Medical Laboratory

Diagnostics - Biomarkers Armune BioScience, Inc. Assay Designs, Inc. Becton Dickinson - Difco Laboratories Biomedical Diagnostics, LLC Biotech Clinical Laboratories Cayman Chemical Company Cell Culture Characterization Services Cutting Image Histology, LLC Detroit R & D, Inc. Eurofins Avtech Laboratories, Inc. Innovative Research Inc.

D I R E C TO RY & R E S O U R C E G U I D E

Invirion, Inc. Johnson & Johnson NextGen Sciences, Inc. OcuSciences, Inc. Oxford Biomedical Research, Inc. Phadia US Quest Diagnostics Incorporated Roche Biomedical Labs Rubicon Genomics, Inc. Sequenom Center for Molecular Medicine Sterling Diagnostics Virotech Co., Inc. Warde Medical Laboratory

Diagnostics - Biosensors Biotectix CVR Global, Inc. MemsTech Rapid BioSense Threefold Sensors, LLC

Diagnostics - Genetic Testing & Index Arrays Antel BioSystems, Inc. AquaBiochip, LLC Bauer BioMedical, LLC deCODE genetics Genemarkers LLC Invirion, Inc. Michigan Technology and Research Institute, LLC Quest Diagnostics Incorporated Roche Biomedical Labs Rubicon Genomics, Inc. Sequenom Center for Molecular Medicine VetGen, LLC Warde Medical Laboratory

Diagnostics - Imaging & Scans Cutting Image Histology, LLC CVR Global, Inc. Diagnostic Instruments Inc. Early Warning Healthcare Institute MIR Preclinical Services (a Charles River Company) OcuSciences, Inc. Xoran Technologies, Inc.

Diagnostics - Molecular Antel BioSystems, Inc. Armune BioScience, Inc. Bauer BioMedical, LLC Becton Dickinson - Difco Laboratories Biomedical Diagnostics, LLC

Biotech Clinical Laboratories Cell Culture Characterization Services CNVGenes LLC Cutting Image Histology, LLC DNADNB LLC GEMA, LLC Genetics Squared, Inc. Giri Diagnostics LLC Invirion, Inc. Lumigen, Inc. Luminos LLC Phadia US Quest Diagnostics Incorporated Roche Biomedical Labs Rubicon Genomics, Inc. Sequenom Center for Molecular Medicine Sterling Diagnostics Virotech Co., Inc. Warde Medical Laboratory

Electronics Manufacturer Saline Electronics

Employee Benefits Cornerstone Benefits, LLC Hylant Group Pinnacle Insurance Partners

Engineering Services Beaumont Services Company LLC Keystone Product Development Midwest Cleanroom Associates, Inc. Monal, Inc./Monal Labs ProPharma Group

Facilities & Construction Beaumont Services Company LLC CRB Consulting Engineers CSM Group Detroit Technical Equipment Company iDesign Solutions, LLC Midwest Cleanroom Associates, Inc. Monal, Inc./Monal Labs Skyline Property Group, Inc. Synergy Group, Inc.

Filter Media Pall Corporation - Life Sciences

Financial Consultants Bank of Ann Arbor Cornerstone Benefits, LLC Doren Mayhew Ernst & Young LLP Hylant Group

91

Freezer & Refrigeration Services Bruce Johnson Service Co.,Inc.

Government Affairs Brooks Kushman Butzel Long Dykema LLC Miller, Canfield, Paddock & Stone, PLC

Government/Economic Development Ann Arbor SPARK Automation Alley Canadian Consulate General City of Marshall Economic Development GoteborgBio - BRG MichBio Michigan Biomass Energy Program Michigan Economic Development Corporation Michigan Israel Business Bridge Michigan Small Business & Technology Development Center Oakland County Planning & Economic Development Southwest Michigan First Southwest Michigan Innovation Center TechTown The Right Place, Inc. West Michigan Science and Technology Initiative

Government/Economic Development - Business Development & Planning Ann Arbor SPARK Automation Alley Canadian Consulate General Oakland County Planning & Economic Development Southwest Michigan First The Right Place

Government/Economic Development - Incubators Ann Arbor SPARK Automation Alley Central Michigan University - Center for Applied Research & Technology GoteborgBio - BRG Michigan Life Science and Innovation Center Michigan Research Institute MidMichigan Innovation Center MTEC

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y category Government/Economic Development Incubators continued...

OUInc. Southwest Michigan First Southwest Michigan Innovation Center TechTown University Corporate Research Park West Michigan Science and Technology Initiative

Government/Economic Development - Small Business Assistance Ann Arbor SPARK Automation Alley Great Lakes Entrepreneur’s Quest Michigan Biomass Energy Program Michigan Economic Development Corporation Michigan Small Business & Technology Development Center MidMichigan Innovation Center Oakland County Planning & Economic Development Southwest Michigan First Southwest Michigan Innovation Center TechTown The Right Place, Inc. West Michigan Science and Technology Initiative

Human Resources American Society of Employers SOI HR Solutions

Industrial & Environmental Bio-Defense Absolute Analytical, Inc. AEGIS Environments Caltech Industries, Inc. Emergent BioSolutions Microbiological Associates, Inc. Plas-Labs, Inc.

Industrial & Environmental Bio-Plastics The Dow Chemical Company

Industrial & Environmental Chemicals AEGIS Environments Bio-lab, Inc., A Chemtura Company Biopolymer Innovations Bridge Organics Co. Burdick & Jackson Dendritech, Inc. Dendritic Nanotechnologies, Inc. Diversified Natural Products

BioMatters | Spring 2009

Draths Industries, LLC Drug & Laboratory Disposal, Inc. EcoSynthetix Emerald BioAgriculture Corporation / Auxein Corporation Haviland Enterprises Intermediary Biochemicals, LLC J. Rettenmaier, USA PVS Chemicals, Inc. Riverside Organics The Dow Chemical Company VenOmix, Inc. Vertellus Health and Specialty Products, LLC Wacker Chemical Corporation

Industrial & Environmental Environmental Cleanup Absolute Analytical, Inc. Bio-lab, Inc., A Chemtura Company Caltech Industries, Inc. Drug & Laboratory Disposal, Inc. Global Remediation Technologies Incorporated HealthCure, LLC Inland Waters Pollution Control Merit Laboratories, Inc.

Industrial & Environmental Enzymes Bio-lab, Inc., A Chemtura Company Proteos, Inc.

Industrial & Environmental Fermentation Alluvium Biosciences Inc. Diversified Natural Products Draths Industries, LLC LEC Tech, Inc. MBI International Working Bugs, LLC

Industrial & Environmental Nanotechnolgies & Products Biotectix Dendritech, Inc. Dendritic Nanotechnologies, Inc. Exponent, Inc. Keweenaw Nanoscience Center Mayaterials MERS, LLC Michigan Molecular Institute Next Generation Therapeutics, Inc. Orthopedic Development, Inc. Plas-Labs, Inc. The Dow Chemical Company XG Sciences, Inc.

92

Industrial & Environmental White Biotechnology Draths Industries, LLC The Dow Chemical Company

Informatics - Bio & Chem BioMedPharmIS, Ltd. Compendia Bioscience Data Integrated Scientific Systems DNA Software, Inc. Gene Codes GeneGo, Inc. Genetics Squared, Inc. Genomatix Software, Inc. MetagenX, LLC POLY Bioinformatics Thomson Healthcare Torrey Path LLC Toxicogenomic Informatics and Solutions, LLC XB TransMed Solutions, LLC

Informatics - Data Capture & Management Agfa Corporation AIS Consulting Arbor Research Collaborative for Health Avicenna Medical Systems, Inc. BioMedware Inc. BioPharma Data Services Compendia Bioscience Critech Research, Inc. Data Integrated Scientific Systems Ddots, Inc. Dermanaut GE Medical Systems Information Technology Gene Codes Genomatix Software, Inc. HealthCure, LLC Innovative Analytics Inc. Integrated Nonclinical Development Solutions, Inc. INVIA Medical Imaging Solutions Kestral Consultants, Inc. McKesson Pharmacy Systems MedImage, Inc. OcuSciences, Inc. POLY Bioinformatics RADAR Medical Systems LLC Sentry Medical Technologies Thomson Healthcare Toxicogenomic Informatics and Solutions, LLC Unival, Inc. Versus Technology, Incorporated XB TransMed Solutions, LLC

D I R E C TO RY & R E S O U R C E G U I D E

Informatics - Development

Informatics - LIMS

Lab Equipment

Arivium, Inc. BioPharma Data Services Compendia Bioscience Ddots, Inc. GE Medical Systems Information Technology Thomson Healthcare XB TransMed Solutions, LLC

Data Integrated Scientific Systems INVIA Medical Imaging Solutions ScreenTrack Thomson Healthcare

Bruce Johnson Service Co.,Inc. Calibrate, Inc. - The Pipet People Detroit Technical Equipment Company Farnell Equipment Company MarketLab O’Mara Products VWR International

Informatics - Enterprise Management Agfa Corporation BlueWare, Inc. Centromine, Inc. Cielo MedSolutions Contented Hearts, Inc. Cybernet Medical Ddots, Inc. Dermanaut GE Medical Systems Information Technology McKesson Pharmacy Systems MedImage, Inc. Optim RADAR Medical Systems LLC ScreenTrack Sentry Medical Technologies Thomson Healthcare Unival, Inc.

Informatics - Healthcare & Wellness Arbor Research Collaborative for Health Avicenna Medical Systems, Inc. Better Rehab, LLC BioMedware Inc. BlueWare, Inc. Centromine, Inc. Cielo MedSolutions Contented Hearts, Inc. Critech Research, Inc. Cybernet Medical Ddots, Inc. Early Warning Healthcare Institute GE Medical Systems Information Technology Linde LLC HealthMedia, Inc. Johnson & Johnson McKesson Pharmacy Systems POLY Bioinformatics RADAR Medical Systems LLC Thomson Healthcare Unival, Inc. Versus Technology, Incorporated YourSurgery.com

Informatics - Research Arbor Research Collaborative for Health BioMedPharmIS, Ltd. BioMedware Inc. BioSTAT Consultants, Inc. Compendia Bioscience Critech Research, Inc. Data Integrated Scientific Systems Ddots, Inc. GE Medical Systems Information Technology Gene Codes GeneGo, Inc. Genetics Squared, Inc. Genomatix Software, Inc. Innovative Analytics Inc. Michigan Center for Biological Information Center for Excellence POLY Bioinformatics Thomson Healthcare Torrey Path LLC Toxicogenomic Informatics and Solutions, LLC XB TransMed Solutions, LLC

Information Services Provider BioMedPharmIS, Ltd. Nature Publishing Co. Pharmacision Science Direct

Information Technology Services & Consulting Arivium, Inc. CSM Group Field Consulting Services, Inc. Fullscope, Inc. Mangosoft MasterControl, Inc. Newport Consulting Group Plex Systems ProPharma Group Switchback

Insurance Providers Brown & Brown of Detroit Chubb Group of Insurance Companies Cornerstone Benefits, LLC Hylant Group Monitor Liability Managers Inc. Pinnacle Insurance Partners

93

Manufacturing Support Beaumont Services Company LLC Calibrate, Inc. - The Pipet People Field Consulting Services, Inc. Global Strategic Connections, LLC National Center for Manufacturing Sciences Plex Systems PTI Engineered Plastics, Inc.

Marketing Consultants AP Bio-Consulting LLC Biotechnology Business Consultants (BBC) Global Strategic Connections, LLC Lindsay Exhibit Group, Inc. Teresa M. Arnold & Associates Wise BioStrategies LLC

Media Michigan Business Review PR Newswire

Medical Devices - Dental Air Force Inc. Akervall Technologies American Dental Technologies, Inc. Axenic Dental, Inc. Bio-Coat Inc. Davis Dental Labs Garrison Dental Solutions Surgitel

Medical Devices - Diagnostics Agfa Corporation Angott Medical Products, LLC Critical Signal Technologies DNADNB LLC Incept BioSystems INRAD, Inc. Life Science Systems, Inc. MedArray Inc. Medtronic Norwind-Cortez RG Medical Diagnostics RJL Systems, Inc. RxDispense, Inc. Sensound Siemens Ultrasound Division

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y category Medical Devices - Diagnostics continued...

Somanetics Corporation Sonetics Ultrasound, Inc. Terumo Heart, Inc. Xoran Technologies, Inc.

Medical Devices - Hospital Equipment & Furnishings Amigo Mobility International Biotronic Neural Monitoring Specialists Cascade Life Solutions CFI Medical Solutions (Contour Fabricators, Inc.) Creative Technology Services Critical Signal Technologies Custom Biogenic Systems Cybernet Medical Delphi Medical Systems Ennew Medical Devices, LLC FlowTech Corporation Grant Manufacturing Corporation Johnson & Johnson Lake Erie Medical and Surgical Lynn Medical Instruments Medical Imaging Resources, Inc. Medi-Nuclear Corp.

Medtronic Michigan Instruments Midbrook, Inc. NEXT Mobility NuStep RG Medical Diagnostics RJL Systems, Inc. Rockwell Medical Technologies, Inc. Skytron Stryker Corporation Surge Medical Solutions Surgitel Tech Initiatives Inc. Terumo Cardiovascular Systems Corp.

Twin Bay Medical, Inc. Vigor Equipment, Inc.

Medical Devices - Lab Tools & Instruments Advanced Photonix Inc. ASI Instruments, Inc. Aspen Surgical Products, Inc. Ateq Corporation Atodyne Technologies LLC Autocam Medical BioFlow Technology, Inc. BioLumix, Inc. Biophotonic Solutions, Inc. Biotronic Neural Monitoring Specialists

BioMatters | Spring 2009

Cascade Life Solutions Covalent Medical, Inc. Coy Laboratory Products Inc. Critical Signal Technologies Custom Biogenic Systems Cybernet Medical Diagnostic Instruments Inc. DNADNB LLC EADevices, Inc. Essen Instruments FlowTech Corporation Grant Manufacturing Corporation Hart Enterprises Incept BioSystems Integrated Sensing Systems (ISSYS) Johnson & Johnson Keystone Product Development KOA Orthopedics Lake Erie Medical and Surgical Life Science Systems, Inc. Lynn Medical Instruments Mager Scientific Inc. MC3, Inc. MedArray Inc. Medical Accessories & Research Corporation Medtronic Nephrion, Inc. NeuroNexus Technologies Omega Surgical Instruments, Inc. Pall Corporation - Life Sciences Plas-Labs, Inc. Precision Edge Surgical Products Protomatic RG Medical Diagnostics Roush Life Sciences Slaughter Instrument Co. SoloHill Engineering, Inc. Stryker Corporation Stryker Instruments Surge Medical Solutions Surgitel Terumo Cardiovascular Systems Corp.

Terumo Heart, Inc. Twin Bay Medical, Inc.

Medical Devices - Medical Imaging Advanced Photonix Inc. Advanced X-Ray Technology, Inc. Agfa Corporation Angott Medical Products, LLC Axsys Technologies, Inc. CardiArc CVR Global, Inc. Diagnostic Instruments Inc.

94

INVIA Medical Imaging Solutions Mager Scientific Inc. Medical Imaging Resources, Inc. MedImage, Inc. M-Vision OcuSciences, Inc. Pixel Velocity Inc. Rigaku Innovative Technologies Sensound Siemens Ultrasound Division Sonetics Ultrasound, Inc. Surgitel Ultrasound Medical Devices, Inc. Xoran Technologies, Inc.

Medical Devices - Prosthetics & Orthotics Becker Orthopedic BioPro Bremer Prosthetics, Inc. Brenner Orthotic and Prosthetic Labs CFI Medical Solutions (Contour Fabricators, Inc.) Christian Roux Ltd. College Park Industries DavisMade, Inc. Elkins Innovations, Inc. Freeman Manufacturing Company Hanger Prosthetics & Orthodics Lake Erie Medical and Surgical Michigan Orthopedic Services Motion Resources, Styker Orthopedic Mt. Clemens Orthopaedic Appliances, Inc. Northwest Orthotics-Prosthetic, Inc. Progressive Dynamics Medical Pros-Tech Prosthetic Center, Inc. Signal Medical Corporation Ultralight Prosthetics, Inc.

Medical Devices - Safety AEGIS Environments Ateq Corporation Creative Technology Services Critical Signal Technologies Danmar Products Inc. Ennew Medical Devices, LLC Freeman Manufacturing Company Grant Manufacturing Corporation Lake Erie Medical and Surgical Lynn Medical Instruments Medi-Nuclear Corp.

Michigan Instruments Michigan Orthopedic Services Plas-Labs, Inc.

D I R E C TO RY & R E S O U R C E G U I D E

Signal Medical Corporation Stryker Corporation Surge Medical Solutions Surgitel

Medical Devices - Sensors Advanced Sensor Technologies, Inc. Bio-Nano Power LLC Biotronic Neural Monitoring Specialists Critical Signal Technologies CVR Global, Inc. Delphi Medical Systems ECO PHYSICS, INC. Integrated Sensing Systems (ISSYS) Life Science Systems, Inc. MC3, Inc. Medtronic MemsTech Michigan Instruments NeuroNexus Technologies Next Generation Therapeutics, Inc. Optical Dimensions Rapid BioSense Selective Technologies, Inc. Sensound Somanetics Corporation Sonetics Ultrasound, Inc. Terumo Cardiovascular Systems Corp.

Ultrasound Medical Devices, Inc.

Medical Devices - Surgical Accord Biomaterials, Inc. Accumed Systems Inc. AI Medical Devices, Inc. Aspen Surgical Products, Inc. ATEK Medical Manufacturing Autocam Medical Avalon Laboratories LLC Bio-Coat Inc. BioPro Cascade Life Solutions Covalent Medical, Inc. Di-Coat Corp Doctor’s Orders, Inc. EADevices, Inc. Exponent, Inc. Ferndale Laboratories Inc. Hart Enterprises HistoSonics, LLC Implants International N.A. INRAD, Inc. Johnson & Johnson Keystone Product Development KOA Orthopedics

LVAD Technology, Inc. MedElute, Inc. Medtronic Micro Machine Co. Monteris Medical, Inc. NeuroNexus Technologies Omega Surgical Instruments, Inc. Orchid Orthopedic Solutions, LLC Orthopedic Development, Inc. Pioneer Surgical Technology Precision Edge Surgical Products Stryker Corporation Stryker Instruments Stryker Orthopedics Surge Medical Solutions Symmetry Jet Terumo Heart, Inc. Thompson Surgical Instruments Topspins, Inc.

Medical Devices - Therapeutic Acuity Medical, Inc. Adamlab, LLC Alivio Corporation Autocam Medical AVAcore Technologies Bio Logic Engineering, Inc. Birchbrook Technologies L.L.C. CFI Medical Solutions (Contour Fabricators, Inc.) Conceivex Covalent Medical, Inc. Creative Technology Services DavisMade, Inc. Delphi Medical Systems EyeLab Group Grant Manufacturing Corporation HAC of America, Inc. HistoSonics, LLC Hygieia, Inc. Implants International N.A. In the Groove, LLC Innovative BioTherapies, Incorporated Lake Erie Medical and Surgical LVAD Technology, Inc. Lynn Medical Instruments MedElute, Inc. Medtronic Monteris Medical, Inc. Nanoderm Therapeutics, Inc. Nephrion, Inc. NuStep Optical Supply

95

Orthopedic Development, Inc. SciTech Development Signal Medical Corporation Stryker Corporation Surge Medical Solutions Symmetry Jet Vigor Equipment, Inc.

Office Furniture Detroit Technical Equipment Company Office Depot VWR International

Pharmaceuticals & Therapeutics Animal Health Bayer Health Care GlaxoSmithKline Horseshoe Herbals Neogen Corporation Pfizer Inc. W.F. Valentine & Co.

Pharmaceuticals & Therapeutics Biologics & Biosimilars Adeona Pharmaceuticals AlphaCore Pharma Amgen Aursos, Inc. Bayer Health Care Biopolymer Innovations Cerenis Therapeutics Inc. Corium International, Inc. deCODE genetics Emergent BioSolutions Esperion Therapeutics, Inc. EXT Lifesciences, Inc. Genentech Genetics Squared, Inc. GlaxoSmithKline GlyTag LLC Implants International N.A. Innovative BioTherapies, Incorporated Johnson & Johnson MuciMed, Inc. NanoBio Corporation NanoVir LLC NephRx Corporation Pfizer Inc. ProNAi Therapeutics, Inc. sanofi-aventis US Secretory IgA Inc. Thromgen Tolera Therapeutics, Inc.

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y category Pharmaceuticals & Therapeutics Cell Based Therapies & Regenerative Medicine Aastrom Biosciences, Inc. Housey Pharmaceutical Research Laboratories, LLC Innovative BioTherapies, Incorporated OtoMedicine, Inc. Pfizer Inc. Tolera Therapeutics, Inc.

Pharmaceuticals & Therapeutics Generics Bayer Health Care Caraco Pharmaceutical Laboratories, Ltd. Corium International, Inc. Eloquest Healthcare Fermical, Inc. Ferndale Laboratories Inc. GlaxoSmithKline Harvard Drug Company JHP Pharmaceuticals Perrigo Company Quality Care Products

Pharmaceuticals & Therapeutics Natural Products Alluvium Biosciences Inc. AureoGen Biosciences, Inc. Aursos, Inc. Biopolymer Innovations Diversified Natural Products Ecology Health Products, Inc. Eloquest Healthcare EXT Lifesciences, Inc. Graminex, LLC Horseshoe Herbals Mycol Balm Laboratories, Inc. Natural Therapeutics, LLC Neocutis Painex Corporation VenOmix, Inc. zuSyn

Pharmaceuticals & Therapeutics Nutriceuticals & Alternative Medicines Cerise Nutraceuticals, Inc. Corium International, Inc. Diversified Natural Products Ecology Health Products, Inc. EXT Lifesciences, Inc. Graminex, LLC Harvard Drug Company

BioMatters | Spring 2009

Horseshoe Herbals Johnson & Johnson Mycol Balm Laboratories, Inc. Natural Therapeutics, LLC Neocutis OtoMedicine, Inc. Painex Corporation SSV Therapeutics, LLC

Pharmaceuticals & Therapeutics OTC Abbott Laboratories Bayer Health Care Cerise Nutraceuticals, Inc. Corium International, Inc. Ecology Health Products, Inc. Eloquest Healthcare EXT Lifesciences, Inc. Ferndale Laboratories Inc. GlaxoSmithKline Harvard Drug Company Johnson & Johnson Mycol Balm Laboratories, Inc. NanoBio Corporation Nanoderm Therapeutics, Inc. Natural Therapeutics, LLC Neocutis OtoMedicine, Inc. Painex Corporation Perrigo Company Pfizer Inc. Quality Care Products

Pharmaceuticals & Therapeutics Synthetic Small Molecule 21st Century Therapeutics, Inc. Abbott Laboratories Adeona Pharmaceuticals AFID Therapeutics, LLC AureoGen Biosciences, Inc. Avidimer Therapeutics, Inc. Bayer Health Care Biomide Biopolymer Innovations Cerenis Therapeutics Inc. deCODE genetics Emiliem Esperion Therapeutics, Inc. Genentech Genetics Squared, Inc. GlaxoSmithKline GlyTag LLC Housey Pharmaceutical Research Laboratories, LLC

96

Jiva Pharma, Inc. Johnson & Johnson Lycera Corporation Meditrina Pharmaceuticals, Inc. Metabolic Solutions Development Company Molecular Therapeutics, Inc. NanoBio Corporation Nanoderm Therapeutics, Inc. NanoMed Pharmaceuticals, Inc. NanoVir LLC Next Generation Therapeutics, Inc. OtoMedicine, Inc. Pfizer Inc. Phrixus Pharmaceuticals, Inc. QuatRx Pharmaceuticals sanofi-aventis US SciTech Development SSV Therapeutics, LLC Takeda Pharmaceuticals North America, Inc. TCH Pharmaceuticals, Inc. Trilithon Pharma, LLC Velcura Therapeutics, Inc. zuSyn

Pharmaceuticals & Therapeutics Vaccines Emergent BioSolutions sanofi-aventis US

Procurement Services Single Source Procurement, LLC

Public Relations Lindsay Exhibit Group, Inc. PR Newswire Teresa M. Arnold & Associates

Real Estate Bluestone Realty Advisors Skyline Property Group, Inc.

Research Tools - Instruments & Equipment Accuri Cytometers Advanced Photonix Inc. ASI Instruments, Inc. Aspen Surgical Products, Inc. Atodyne Technologies LLC Becton Dickinson - Difco Laboratories BioFlow Technology, Inc. BioLumix, Inc. Biophotonic Solutions, Inc. Biotronic Neural Monitoring Specialists Clean Air Technology

D I R E C TO RY & R E S O U R C E G U I D E

Custom Biogenic Systems Data Integrated Scientific Systems Diagnostic Instruments Inc. Digilab Genomic Solutions DNADNB LLC ECO PHYSICS, INC. FlowTech Corporation Gene Codes GeneGo, Inc. Genomatix Software, Inc. Handy Lab, Inc. Incept BioSystems Integrated Sensing Systems (ISSYS) Jade Scientific Life Science Systems, Inc MedArray Inc. Medical Accessories & Research Corporation Medi-Nuclear Corp.

Pall Corporation - Life Sciences PBS Biotech Phadia US Pointe Scientific, Inc. Richard-Allan Scientific Rigaku Innovative Technologies RJL Systems, Inc. Roush Life Sciences Sterling Diagnostics Systems Specialties Terumo Cardiovascular Systems Corp.

Thorn Smith Laboratories

Research Tools - Lab Furnishings Clean Air Technology Jade Scientific

Research Tools - Reagents & Materials 3D Biomatrix Accuri Cytometers ApoLife, Inc. Assay Designs, Inc. Asterand, Inc. Becton Dickinson - Difco Laboratories Berry & Associates, Inc. Biodiscovery, LLC BioLumix, Inc. Biosol, Ltd. Biotectix Cayman Chemical Company CNVGenes LLC Covalent Medical, Inc. Detroit R & D, Inc. Digilab Genomic Solutions Giri Diagnostics LLC

GlyTag LLC Handy Lab, Inc. HealthCure, LLC Implants International N.A. Incept BioSystems Innovative Research Inc. Intermediary Biochemicals, LLC Invirion, Inc. Jade Scientific JV Biolabs Lumigen, Inc. Luminos LLC Michigan Antibody Technology Center - Center of Technology Excellence Michigan Diagnostics LLC Molecular Innovations Inc. NanoMed Pharmaceuticals, Inc. Neogen Corporation Nitrate Elimination Company, Inc. Originus, Inc. Oxford Biomedical Research, Inc. Pall Corporation - Life Sciences Phadia US PhycoTech Pointe Scientific, Inc. Proteos, Inc. Richard-Allan Scientific Rockwell Medical Technologies, Inc. Rubicon Genomics, Inc. Sequenom Center for Molecular Medicine SoloHill Engineering, Inc. Sterling Diagnostics Systems Specialties Thorn Smith Laboratories XG Sciences, Inc.

Research Tools - Testing & Kits ApoLife, Inc. Assay Designs, Inc. Becton Dickinson - Difco Laboratories BioLumix, Inc. Cayman Chemical Company CNVGenes LLC Detroit R & D, Inc. Digilab Genomic Solutions Giri Diagnostics LLC Handy Lab, Inc. Lumigen, Inc. Mainline Technologies International Michigan Diagnostics LLC Micromyx, LLC Molecular Innovations Inc. Neogen Corporation NextGen Sciences, Inc.

97

Nitrate Elimination Company, Inc. Originus, Inc. Oxford Biomedical Research, Inc. Phadia US PhycoTech Pointe Scientific, Inc. Richard-Allan Scientific Rubicon Genomics, Inc. Sequenom Center for Molecular Medicine Sterling Diagnostics Thorn Smith Laboratories

Software Arivium, Inc. Fullscope, Inc. MasterControl, Inc. Plex Systems ProPharma Group

Staffing & Recruiting SOI HR Solutions The Point Services Trialon Corporation

Strategy/Planning Apjohn Group, LLC Aptuit Consulting, Inc. Biotechnology Business Consultants (BBC) Caladium Consulting Collet Consulting, LLC Global Strategic Connections, LLC Lindsay Exhibit Group, Inc. Newport Consulting Group SOI HR Solutions TEDCo - Technology Enterprise Development Co., Inc. Teresa M. Arnold & Associates Wise BioStrategies LLC

Supplier Detroit Technical Equipment Company Farnell Equipment Company Linde LLC Office Depot O’Mara Products Single Source Procurement, LLC VWR International

Technical Writing Aptuit Consulting, Inc Biotechnology Business Consultants (BBC) ProPharma Group

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y category University/Institution/Hospital – Academic/Education Central Michigan University - Office of Research and Sponsored Programs Central Michigan University - Research Corporation Grand Valley State University Institute for Preventive Sports Medicine Lenawee Intermediate School District Michigan Molecular Institute Michigan State University - Institute for Health Care Studies Michigan State University - MSU Technologies Michigan State University – Office of Research & Graduate Studies Michigan State University - Product Center for Agriculture and Natural Resources Michigan Technological University - Office of Technology and Economic Development Oakland University The MRI Institute for Biomedical Research Imaging University of Michigan - Biomedical Engineering University of Michigan - Coulter Translational Research Partnership Program University of Michigan - Life Sciences Institute University of Michigan - Medical Innovation Center University of Michigan - Michigan Center for Oral Health University of Michigan - Michigan Institute for Clinical Health Research University of Michigan - Michigan Nanotechnology Institute for Medicine and Biological Sciences University of Michigan – Office of VicePresident for Research University of Michigan - Technology Transfer Office Wayne State University - Technology Commercialization Wayne State University Applied Genomic Technologies - Center for Technology Excellence

University/Institution/Hospital Clinical/Hospital Beaumont Hospitals Borgess Research Institute Henry Ford Health System Institute for Health Care Studies Institute for Health Studies Institute for Preventive Sports Medicine Karmanos Cancer Institute

BioMatters | Spring 2009

The MRI Insititute for Biomedical Research Imaging University of Michigan - Medical Innovation Center University of Michigan - Michigan Center for Oral Health University of Michigan - Michigan Institute for Clinical Health Research University of Michigan - Michigan Nanotechnology Institute for Medicine and Biological Sciences Wayne State University Applied Genomic Technologies - Center for Technology Excellence

University/Institution/Hospital Contract Work Altarum Institute Beaumont Hospitals Biosciences Research & Commercialization Center - Center for Technology Excellence Borgess Research Institute Institute for Health Studies MBI International Michigan Animal Model Consortium Center for Technology Excellence Michigan Biological Imaging Center - Center for Technology Excellence Michigan Center for Biological Information Center for Technology Excellence Michigan Molecular Institute Michigan State University - Michigan Center for Structural Biology - Center for Technology Excellence University of Michigan - Michigan Institute for Clinical Health Research University of Michigan - Michigan Proteome Consortium - Center for Technology Excellence Wayne State University Applied Genomic Technologies - Center for Technology Excellence

University/Institution/Hospital Private Altarum Institute Beaumont Hospitals Borgess Research Institute Henry Ford Health System Institute for Health Studies Karmanos Cancer Institute Michigan Animal Model Consortium Center for Technology Excellence Michigan Antibody Technologies Center Center For Technology Excellence Michigan Molecular Institute The MRI Institute for Biomedical Research Imaging Van Andel Institute

98

University/Institution/Hospital Public Biosciences Research & Commercialization Center - Center for Technology Excellence Central Michigan University - Office of Research and Sponsored Programs Central Michigan University - Research Corporation Grand Valley State University Michigan Biological Imaging Center - Center for Technology Excellence Michigan Center for Biological Information Center for Technology Excellence Michigan High Throughput Screening Center Center for Technology Excellence Michigan State University - Michigan Center for Structural Biology - Center for Technology Excellence Michigan State University - MSU Technologies Michigan State University – Office of Research & Graduate Studies Michigan State University - Product Center for Agriculture and Natural Resources Michigan Technological University Office of Technology and Economic Development Michigan Universities Commercialization Initiative (MUCI) Oakland University University of Michigan - Biomedical Engineering University of Michigan - Coulter Translational Research Partnership Program University of Michigan - Life Sciences Institute University of Michigan - Medical Innovation Center University of Michigan - Michigan Center for Oral Health University of Michigan - Michigan Institute for Clinical Health Research University of Michigan - Michigan Nanotechnology Institute for Medicine and Biological Sciences University of Michigan - Michigan Proteome Consortium - Center for Technology Excellence University of Michigan – Office of VicePresident for Research University of Michigan - Technology Transfer Office Wayne State University - Technology Commercialization Wayne State University Applied Genomic Technologies - Center for Technology Excellence

D I R E C TO RY & R E S O U R C E G U I D E

University/Institution/Hospital Research Altarum Institute Beaumont Hospitals Biosciences Research & Commercialization Center - Center for Technology Excellence Borgess Research Institute Central Michigan University - Office of Research and Sponsored Programs Central Michigan University - Research Corporation Grand Valley State University Henry Ford Health System Institute for Health Studies Institute for Preventive Sports Medicine Karmanos Cancer Institute MBI International Michigan Animal Model Consortium Center for Technology Excellence Michigan Biological Imaging Center - Center for Technology Excellence Michigan Center for Biological Information Center for Technology Excellence Michigan Molecular Institute Michigan State University - Michigan Center for Structural Biology - Center for Technology Excellence Michigan State University - MSU Technologies Michigan State University – Office of Research & Graduate Studies Michigan State University - Product Center for Agriculture and Natural Resources Michigan Technological University - Office of Technology and Economic Development Michigan Universities Commercialization Initiative (MUCI) Oakland University Quantum Laboratories The MRI Institute for Biomedical Research Imaging University of Michigan - Biomedical Engineering University of Michigan - Coulter Translational Research Partnership Program University of Michigan - Life Sciences Institute University of Michigan - Medical Innovation Center University of Michigan - Michigan Center for Oral Health University of Michigan - Michigan Institute for Clinical Health Research University of Michigan - Michigan Nanotechnology Institute for Medicine and Biological Sciences University of Michigan - Michigan Proteome Consortium - Center for Technology Excellence

University of Michigan - Office of Vice President for Research University of Michigan - Technology Transfer Office Van Andel Institute Wayne State University - Technology Commercialization Wayne State University Applied Genomic Technologies - Center for Technology Excellence

University/Institution/HospitalTech Transfer Beaumont Commercialization Center Biosciences Research & Commercialization Center - Center for Technology Excellence Borgess Research Institute Central Michigan University - Office of Research and Sponsored Programs Central Michigan University - Research Corporation Grand Valley State University Great Lakes Drug Development, Inc. Michigan Technological University Office of Technology and Economic Development Michigan Universities Commercialization Initiative (MUCI) Michigan State University - MSU Technologies Michigan State University - Product Center for Agriculture and Natural Resources Oakland University University of Michigan - Medical Innovation Center University of Michigan - Technology Transfer Office Van Andel Institute Wayne State University - Technology Commercialization

Venture & Angel Capital Apjohn Group, LLC Arboretum Ventures Ardesta, LLC Capital Advisors Group, Inc. Great Lakes Angels, Inc. Michigan Life Ventures, LLC MicroDose Life Sciences, LLC

99

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y C ounties Allegan

Houghton

Drug & Laboratory Disposal, Inc. Perrigo Company Team Pharmaceutical Inc.

Keweenaw Nanoscience Center Michigan Technological University Office of Technology and Economic Development Nitrate Elimination Company, Inc. Tech Initiatives Inc.

Benzie Alivio Corporation Invirion, Inc. Thorn Smith Laboratories

Huron

Berrien

Ingham

GeneGo, Inc. Horseshoe Herbals PhycoTech Slaughter Instrument Co. Vigor Equipment, Inc.

Calhoun City of Marshall Economic Development Kellogg Company Progressive Dynamics Medical

Chippewa Ecology Health Products, Inc. Precision Edge Surgical Products

Clinton Michigan Corn Growers Association/Corn Marketing Program of Michigan

Eaton Michigan Primary Care Association

Genesee Bremer Prosthetics, Inc. CFI Medical Solutions (Contour Fabricators, Inc.) DavisMade, Inc. Motion Resources, Styker Orthopedic Omega Surgical Instruments, Inc. Selective Technologies, Inc. TEDCo - Technology Enterprise Development Co., Inc.

Grand Traverse Cerise Nutraceuticals, Inc. Global Remediation Technologies Incorporated The Point Services Thompson Surgical Instruments Twin Bay Medical, Inc. Versus Technology, Incorporated

Hillsdale W.F. Valentine & Co.

BioMatters | Spring 2009

Symmetry Jet Toxicogenomic Informatics and Solutions, LLC Working Bugs, LLC XG Sciences, Inc.

Ionia Conceivex

Thumb Oilseed Producers

Isabella

AFID Therapeutics Inc. AI Medical Devices, Inc. Antel BioSystems, Inc. AquaBiochip, LLC Biophotonic Solutions, Inc. Biopolymer Innovations Draths Industries, LLC EcoSynthetix Emerald BioAgriculture Corporation / Auxein Corporation Emergent BioSolutions Fraunhofer USA CCL GEMA, LLC Institute for Health Studies Intermediary Biochemicals, LLC LEC Tech, Inc. MBI International McClinchey Histology Lab, Inc. Merit Laboratories, Inc. MetagenX, LLC Michigan Agri-Business Association Michigan Association of Health Plans Michigan Biomass Energy Program Michigan Center for Structural Biology Center for Technology Excellence Michigan Chemistry Council Michigan Economic Development Corporation Michigan Health & Hospital Association Michigan Health Council Michigan Medical Dental Association Michigan Nurses Association Michigan Osteopathic Association Michigan State Medical Society Michigan State University, Office of Research and Graduate Studies MSU Technologies, Michigan State University Neogen Corporation Orchid Orthopedic Solutions, LLC PBS Biotech Plas-Labs, Inc. Product Center for Agriculture and Natural Resources, Michigan State University Prosthetic Center, Inc. Rapid BioSense

100

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Jackson Coy Laboratory Products Inc. Midbrook, Inc. Sparton Medical Systems TransPharm Preclinical Solutions, LLC

Kalamazoo ADMETRx Apjohn Group, LLC Armune BioScience, Inc. AureoGen Biosciences, Inc. Aursos, Inc. Axenic Dental, Inc. AzoRx, Inc. BioMedPharmIS, Ltd. Biosciences Research & Commercialization Center - Center for Technology Excellence Biosciences Research and Commercialization Center at Western Michigan University BioSTAT Consultants, Inc. Borgess Research Institute Bridge Organics Co. CeeTox, Inc. Charles River Contented Hearts, Inc. CRB Consulting Engineers CSM Group EADevices, Inc. Emiliem Ennew Medical Devices, LLC Eurofins Avtech Laboratories, Inc. FlowTech Corporation Genemarkers LLC Global Clinical Connections HAC of America, Inc. Hanger Prosthetics & Orthodics HistoSonics, LLC�

Honigman Miller Schwartz and Cohn LLP

D I R E C TO RY & R E S O U R C E G U I D E

Innovative Analytics Inc. J. Rettenmaier, USA Jasper Clinical Research & Development, Inc. Kalexsyn, Inc. KAR Bioanalytical, Inc. Keystone Product Development Komodo Pharmaceutical Services, LLC MedElute, Inc. Metabolic Solutions Development Company Michigan Biological Imaging Center - Center for Technology Excellence Michigan Business Review Michigan High Throughput Screening Center - Center of Technology Excellence Micro Machine Co. Micromyx, LLC Monteris Medical, Inc. MuciMed, Inc. NanoMed Pharmaceuticals, Inc. NanoVir LLC NephRx Corporation Orthopedic Development, Inc. OtoMedicine, Inc. Pfizer Inc. Phadia US PharmMor Consulting, LLC PharmOptima, LLC ProNAi Therapeutics, Inc. ProPharma Group Proteos, Inc. Richard-Allan Scientific S & J Laboratories Single Source Procurement, LLC Southwest Michigan First Southwest Michigan Innovation Center Stryker Corporation Stryker Instruments Tolera Therapeutics, Inc. Trilithon Pharma, LLC VenOmix, Inc. zuSyn

Kent Access Business Group Arivium, Inc. Aspen Surgical Products, Inc. ATEK Medical Manufacturing Autocam Medical Avalon Laboratories LLC Bio-Chem Laboratories, Inc. Cascade Life Solutions ClinXus Corium International, Inc. Davis Dental Labs Elkins Innovations, Inc. Ernst & Young LLP

Gerontology Network Grand River Aseptic Pharmaceutical Packaging, Inc. Grand Valley State University Hart Enterprises Haviland Enterprises INRAD, Inc. Juvenile Diabetes Research Foundation - West Michigan MarketLab Medbio, Inc. Medtronic Michigan Animal Model Consortium Center for Technology Excellence Michigan Antibody Technology Center - Center of Technology Excellence Michigan Instruments Michigan Small Business & Technology Development Center Midwest Cleanroom Associates, Inc. O’Mara Products Optical Supply Pinnacle Insurance Partners Price, Heneveld, Cooper, DeWitt & Litton Rose Technologies Sequenom Center for Molecular Medicine Skytron Surge Medical Solutions The Right Place, Inc. Van Andel Institute Varnum, Riddering, Schmidt & Howlett Warner Norcross & Judd LLP West Michigan Regional Laboratory West Michigan Science and Technology Initiative XB TransMed Solutions, LLC

Birchbrook Technologies L.L.C. College Park Industries Custom Biogenic Systems Mt. Clemens Orthopaedic Appliances, Inc. PTI Engineered Plastics, Inc. RJL Systems, Inc. Sterling Diagnostics

Manistee Der-Balian Inc.

Marquette Pioneer Surgical Technology

Mason Diversified Natural Products

Midland AEGIS Environments Caltech Industries, Inc. Crissman Toxicologic Pathology, LLC Dendritech, Inc. GANTEC, Inc. Life Science Systems, Inc. Michigan Molecular Institute MidMichigan Innovation Center Pathology Experts, LLC The Dow Chemical Company

Missaukee BlueWare, Inc.

Monroe Lake Erie Medical and Surgical Quality Care Products Teresa M. Arnold & Associates

Muskegon

Lenawee Bio-lab, Inc., A Chemtura Company Lenawee Intermediate School District Uckele Health and Nutrition Wacker Chemical Corporation

Bayer CropScience Burdick & Jackson Northern Biomedical Research, Inc. Tower Laboratories Montague

Newaygo

Livingston

Gerber Product Company

Acuity Medical, Inc. BioFlow Technology, Inc Bruce Johnson Service Co., Inc. deCODE genetics Great Lakes Drug Development, Inc. International Partnership for Critical Markers of Disease (CMOD)

Macomb 21st Century Therapeutics, Inc. ASI Instruments, Inc.

101

Oakland Absolute Analytical, Inc. Adamlab, LLC Advanced X-Ray Technology, Inc. American Dental Technologies, Inc. American Diabetes Association American Society of Employers Angott Medical Products, LLC AP Bio-Consulting LLC

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y C ounties Oakland continued...

Automation Alley Axsys Technologies, Inc. Beaumont Commercialization Center Beaumont Hospitals Beaumont Services Company LLC Becker Orthopedic Bio-Coat Inc. Biotech Clinical Laboratories Boro Pharm, LLC Brooks Kushman Cell Culture Characterization Services Chubb Group of Insurance Companies CNVGenes LLC Cornerstone Benefits, LLC Critical Signal Technologies Delphi Medical Systems Detroit Technical Equipment Company Diagnostic Instruments Inc. Di-Coat Corp DNADNB LLC Doeren Mayhew Early Warning Healthcare Institute Eloquest Healthcare Exponent, Inc. EXT Lifesciences, Inc. Farnell Equipment Company Fermical, Inc. Ferndale Laboratories Inc. Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C. Giri Diagnostics LLC Global Strategic Connections, LLC GlyTag LLC Great Lakes Angels, Inc. Harness, Dickey & Pierce, P.L.C. HealthCure, LLC Healthtreat, Inc. Housey Pharmaceutical Research Laboratories, LLC iDesign Solutions, LLC Innovative Cell Technology Innovative Research Inc. JHP Pharmaceuticals Johnson & Johnson Juvenile Diabetes Research Foundation - Metro Detroit & SE Michigan KOA Orthopedics Lumigen, Inc. Lynn Medical Instruments Maximax International Inc. Medi-Nuclear Corp.

Michigan Citizens for Stem Cell Research and Cures (MCSCRC) Michigan Diagnostics LLC Microbiological Associates, Inc.

BioMatters | Spring 2009

Microcide, Inc. MicroDose Life Sciences, LLC Miller, Canfield, Paddock & Stone, P.L.C. Molecular Innovations Inc. Monal, Inc./Monal Labs Newport Consulting Group Northwest Orthotics-Prosthetic, Inc. Oakland County Planning & Economic Development Oakland University Optical Dimensions Optim Oxford Biomedical Research, Inc. Phillips Plastics Corporation Plex Systems PR Newswire Pros-Tech Quantum Laboratories Quest Diagnostics Incorporated Quest Research Institute RADAR Medical Systems LLC Rader, Fishman & Grauer PLLC Regulatory Affairs Associates, LLC RG Medical Diagnostics Rigaku Innovative Technologies Rockwell Medical Technologies, Inc. RxDispense, Inc. SANDAB Group Skyline Property Group, Inc. Somanetics Corporation Synergy Group, Inc. Systems Specialties Trialon Corporation Troy Polymers Western Slope Laboratory Williams Syndrome Association YourSurgery.com

Ontonagon SubTerra LLC

Ottawa Air Force Inc. Doctor’s Orders, Inc. Garrison Dental Solutions Mead Johnson Nutritionals Medical Accessories & Research Corporation SPI Pharma Vertellus Health and Specialty Products, LLC Welch Laboratories, Inc.

Saginaw Agrium Amigo Mobility International DuPeron Medical Systems Field Neuroscience Institute

102

Graminex, LLC In the Groove, LLC Michigan Soybean Promotion Committee Mycol Balm Laboratories, Inc. Orchard Unique

St. Clair BioPro Signal Medical Corporation

St. Joseph Abbott Laboratories Freeman Manufacturing Company

Van Buren Albemarle Corporation MPI Research

Washtenaw 3D Biomatrix AAPharmaSyn LLC Aastrom Biosciences, Inc. Accord Biomaterials, Inc. Accumed Systems Inc. Accuri Cytometers Adeona Pharmaceuticals Advanced Photonix Inc. AIS Consulting Akervall Technologies Alluvium Biosciences Inc. AlphaCore Pharma Altarum Institute American Society for Microbiology Ann Arbor Clinical Research Ann Arbor SPARK Arbor Preclinical & Consulting, LLC Arbor Research Collaborative for Health Arboretum Ventures Ardesta, LLC Assay Designs, Inc. Atodyne Technologies LLC AVAcore Technologies Avicenna Medical Systems, Inc. Avidimer Therapeutics, Inc. Bank of Ann Arbor Berry & Associates, Inc. Better Rehab, LLC Bio Logic Engineering, Inc. Biodiscovery, LLC BioLumix, Inc Biomedical Diagnostics, LLC BioMedware Inc. BioPharma Data Services Biosol, Ltd. Biotechnology Business Consultants (BBC)

D I R E C TO RY & R E S O U R C E G U I D E

Biotectix Biotronic Neural Monitoring Specialists Bluestone Realty Advisors Brinks, Hofer, Gilson & Lione Brown & Brown of Detroit Butzel Long Caladium Consulting Calibrate, Inc. Cascade Hemophilia Consortium Cayman Chemical Company Centromine, Inc. Cerenis Therapeutics Inc. Christian Roux Ltd. Cielo MedSolutions ClinSite, Inc. Collet Consulting, LLC Compendia Bioscience Coulter Translational Research Partnership Program, University of Michigan Covalent Medical, Inc. Critech Research, Inc. Cutting Image Histology, LLC Cybernet Medical Danmar Products Inc. Data Integrated Scientific Systems DBA Analytical (an NSF International Company) Ddots, Inc. Dermanaut Digilab Genomic Solutions DNA Software, Inc. ECO PHYSICS, INC. Essen Instruments EyeLab Group Field Consulting Services, Inc. Fulcrum Pharma Developments, Inc. GE Medical Systems Information Technology Gene Codes Genetics Squared, Inc. GeneVivo, LLC Genomatix Software, Inc. Gift of Life Michigan GoteborgBio - BRG Great Lakes Entrepreneur’s Quest Hamztec LLC Handy Lab, Inc. HealthMedia, Inc. Hygieia, Inc. Hylant Group i3 STATPROBE, Inc. Implants International N.A. Incept BioSystems Innovative BioTherapies, Incorporated Institute for Preventive Sports Medicine

Integrated Nonclinical Development Solutions, Inc. Integrated Sensing Systems (ISSYS) International Discovery Sourcing Consultants LLC INVIA Medical Imaging Solutions Jiva Pharma, Inc. JV Biolabs Kendle International Kestrel Consultants, Inc. Koppert Biological Systems, Inc. Lead Biopharma Consulting, LLC Lindsay Exhibit Group, Inc. Luminos LLC Mager Scientific Inc. Mainline Technologies International Mayaterials MC3, Inc. MedArray Inc. Medical Imaging Resources, Inc. Medical Innovation Center, University of Michigan MedImage, Inc. Meditrina Pharmaceuticals, Inc. MERS, LLC MichBio Michigan Center for Biological Information Center for Technology Excellence Michigan Center for Oral Health Michigan Institute for Clinical Health Research Michigan Israel Business Bridge Michigan Life Ventures, LLC Michigan Nanotechnology Institute for Medicine and Biological Sciences Michigan Proteome Consortium - Center for Technology Excellence Michigan Research Institute Michigan Science Teachers Association Michigan Technology and Research Institute, LLC Michigan Universities Commercialization Initiative (MUCI) Michigan Venture Capital Association MIR Preclinical Services (Molecular Imaging Research) Molecular Therapeutics, Inc. NanoBio Corporation Nanoderm Therapeutics, Inc. National Center for Manufacturing Sciences National Kidney Foundation of Michigan Natural Therapeutics, LLC Nephrion, Inc. NeuroNexus Technologies Next Generation Therapeutics, Inc. NextGen Sciences, Inc.

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Norwind-Cortez NuStep Nymirum OcuSciences, Inc. Ophthigenics LLC Originus, Inc. Pall Corporation - Life Sciences Phrixus Pharmaceuticals, Inc. Pixel Velocity Inc. POLY Bioinformatics Protomatic QuatRx Pharmaceuticals RTI Health Solutions Rubicon Genomics, Inc. Saline Lectronics, Inc. ScarPrev Pharmaceuticals ScreenTrack Secretory IgA Inc. Sentry Medical Technologies Siemens Ultrasound Division Smith Haughey Rice & Roegge SOI HR Solutions SoloHill Engineering, Inc. Sonetics Ultrasound, Inc. SSV Therapeutics, LLC Surgitel Switchback TCF National Bank TCH Pharmaceuticals, Inc. TERRE Clinical Research Services, Inc. Terumo Cardiovascular Systems Corp.

Terumo Heart, Inc. Thomson Healthcare Threefold Sensors, LLC Thromgen Topspins, Inc. Torrey Path LLC TSRL, Inc. Ultrasound Medical Devices, Inc. United BioSource Corporation University of Michigan - Biomedical Engineering University of Michigan - Life Sciences Institute University of Michigan - Office of Vice President for Research University of Michigan - Technology Transfer Office Velcura Therapeutics, Inc. Velesco Pharma Services VetGen, LLC VWR International Warde Medical Laboratory Wise BioStrategies LLC Xoran Technologies, Inc.

BioMatters | Spring 2009

D I R E C TO RY & R E S O U R C E G U I D E L isting b y C ounties Wayne Advanced Sensor Technologies, Inc. ApoLife, Inc. Ash Stevens Asterand, Inc. Ateq Corporation Becton Dickinson - Difco Laboratories Biomide Brenner Orthotic and Prosthetic Labs Canadian Consulate General Caraco Pharmaceutical Laboratories, Ltd. CardiArc Clean Air Technology Clinical Ligand Assay Society Creative Technology Services CVR Global, Inc. Detroit R & D, Inc. Dykema, PLLC Eliason Consulting Esperion Therapeutics, Inc. Fullscope, Inc. Grant Manufacturing Corporation Harvard Drug Company Henry Ford Health System Inland Waters Pollution Control Jade Scientific Karmanos Cancer Institute Law Offices of Gary Kendra, PC LVAD Technology, Inc. Lycera Corporation McKesson Pharmacy Systems MemsTech Michigan Orthopedic Services MMS Holdings Inc. M-Vision Neocutis NEXT Mobility Painex Corporation Paragon Laboratories, Inc. Pharmacision LLC Pointe Scientific, Inc. PVS Chemicals, Inc. Riverside Organics Roche Biomedical Labs Roush Life Sciences SciTech Development Sensound Shanghai Bio Corporation Shrader Analytical and Consulting Laboratories, Inc. Stryker Orthopedics TechTown

BioMatters | Spring 2009

The MRI Insititute for Biomedical Research Imaging Ultralight Prosthetics, Inc. Virotech Co., Inc. Vortech Pharmaceuticals Wayne State University - Technology Commercialization Wayne State University Applied Genomic Technologies - Center for Technology Excellence

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UNMATCHED ACCESS. UNCOMPROMISING RESULTS. Strategic Sale Advisory

Targeted Acqusition Search

Capital Raising Intellectual Property/ Product Line Divestitures

Strategic Consulting

In the life sciences sector, it takes deep industry access and a highly-disciplined approach to generate premium value in a transaction. At P&M Corporate Finance, our expertise in the medical device, diagnostics, and healthcare sectors, combined with our expansive industry relationships, affords us a unique perspective in the industry. Whether your goal is to sell, execute an acquisition strategy, or obtain capital, you can rely on our experienced professionals.

Contact our Life Sciences team today to find out how we can make a difference in your transaction.

Bryan Hughes • 248.223.3678 • bryan.hughes@pmcf.com Phil Gilbert • 248.223.3326 • phil.gilbert@pmcf.com Detroit • Chicago • Cleveland • pmcf.com

wouLD HeLP

Me Grow My business.

its educated and innovative people would give companies like mine the resources to create and discover new medicines to treat life-threatening human diseases. its county would initiate economic development programs to help companies like ours attract and retain outstanding research scientists to keep our businesses growing. My ideal City would keep me connected to a network of more than 2,000 other high-tech research and development facilities in the same county. but my ideal City is not just ideal, it’s real, and can be found in oakland County, Michigan.

Find out more about your Ideal City at globaloakland.com Gerard M. Housey, M.D., Ph.D.

President and CEO Housey Pharmaceutical Research Laboratories Southfield, Michigan

Oakland cOunty’s

Medical Main street T h e r o a d T o i n n o vaT i o n