BioMatters - Spring 2010

BioMatters SPRING 2010

A MichBio Publication Showcasing Michigan’s Biosciences Industry

Venture Capital Stacking Up

for Michigan’s Bioscience

Companies In This Issue: 2010 Michigan Biosciences Directory and Resource Guide

Also Featured: Engaging Michigan’s Young Scientists: Innovative Programs that Make Science “Cool” State Legislators on Leading Edge in Bioscience Focus

G o v e rnor ’ s M E S S A G E

Dear Innovators:

A strong, thriving biosciences industry is a vital part of our ongoing efforts to diversify Michigan’s economy. I am inspired by the innovations of our 525-plus biotech companies and delighted that they are pushing ahead with investments, expansions, and new job creation.

Major bio-corporations, Stryker and Perrigo, are thriving. MPI Research is on track to open its downtown Kalamazoo laboratories this year. And Detroit will host the 2010 World Stem Cell Summit in October. All of this activity represents meaningful growth ahead for the life sciences in Michigan.

Michigan offers everything necessary for a strong and growing biotech industry, including and most importantly, a broad and deep pool of technical talent. The Southwest Michigan Innovation Center has launched more than two dozen life sciences companies so far. We are assured of more as Michigan’s aggressive initiatives — investments totaling more than half a billion dollars in services, commercialization resources, and facilities — support our entrepreneurs and nurture tech startups.

Our base of expert life-sciences professionals is backed by a world-class university research apparatus that acts as a catalyst for bio-innovation. In Ann Arbor, the two-million-square-foot former Pfizer facility acquired by the University of Michigan (U of M), has identified the first core technology areas at what is now called the North Campus Research Complex, including nanotechnology, molecular imaging, and drug delivery. The site will also house research in clean energy to enable future collaborations in biofuels. In Detroit, Wayne State University’s TechTown, one of Michigan’s 15 SmartZone technology clusters, is overflowing with 165 small businesses and planning to quadruple the business incubator’s space. Human tissue bio-repository Asterand plc, now publicly traded on the London Stock Exchange, was TechTown’s first tenant a decade ago.

We see progress, too, in the availability of capital for our emerging biotechs. Michigan is home to 16 venture capital funds, and one of only nine states to offer state fund-of-fund investment programs. Recent successes include U of M spinoffs NanoBio, HealthMedia, and HandyLab.

We will continue to grow Michigan’s biotechnology sector as part of our aggressive efforts to diversify the state’s economy.

Commercialization activities, venture capital, and other growth opportunities created by our targeted initiatives ensure that Michigan will continue as an innovative and increasingly important life sciences center well into the future.

Jennifer M. Granholm, Governor of Michigan

The Catalyst for Bio Innovation

BIO 2010 Ad The Michigan Economic Development Corporation (MEDC) has worked hard to make Michigan a bioscience hotbed.

With more than $300 million invested in R&D, infrastructure, technology transfer and early-stage companies over the past decade, we have cultivated an environment where innovation thrives.

Visit MichiganAdvantage.org today and discover how the MEDC can give your biosciences company the Upper Hand.

Come see us at Booth 3900 in the Midwest Pavillon at the 2010 Bio International Convention

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BioMatters | Spring 2010

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WWW.BROOKSPARK.COM

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PRESIDENT’S MESSAGE

P R O F E S S I O N A L S TA F F

Michigan’s Biosciences Industry Welcomes You!

Michigan is home to a strong biosciences industry with a rich legacy that originated

with the likes of Parke-Davis Pharmaceuticals (the first U.S. based pharmaceutical company), the Upjohn Company, Stryker and Perrigo. Today, the state’s biosciences community consists of almost 41,000 talented and skilled employees found in over 525 companies and institutions, coupled with another 58,000 spinoff jobs. They cover the breadth of pharma/biotech, medical devices/equipment, research products and diagnostics, informatics, ag-bio, bio-defense, bio-environmental, industrial biotechnology, testing/medical laboratories and clinical research.

What best defines Michigan’s biosciences industry? In a word — success! Over the last

eight years our bioscience companies have achieved a remarkable track record of investment, growth, and return. We’ve seen more than 120 companies launched largely through $323 million of State of Michigan support, as well as an additional $46 million of investment by the state’s fund-to-funds that were directed to biotech start-ups. Capital investment under management in Michigan’s emerging companies exceeded $1 billion last year.

More importantly, Michigan bio-companies have realized numerous successful exits

such as Esperion Therapeutics ($1.4 billion purchase by Pfizer in 2004), Lumigen (acquired

by Beckman Coulter in 2008), HealthMedia (bought by Johnson & Johnson in early 2009), and HandyLab (purchased by Becton Dickinson in late 2009). In addition, various emerging biotech companies including Accuri Cytometers, NanoBio, Lycera, and HistoSonics have procured large venture capital investments during the same period. The bottom line is that ‘success breeds success’ when it comes to Michigan’s biosciences industry.

Stephen T. Rapundalo, Ph.D. President and CEO srapundalo@michbio.org 734.527.9144 Jayne Berkaw Director, Marketing and Communications jayne@michbio.org 734.527.9147 Heather Kusiak Manager, Operations and Membership heather@michbio.org 734.527.9150 Nancy Marcotte Manager, Finance nancy@michbio.org 734.527.9145

In this issue of BioMatters you’ll read about the many resources, programs, incentives

and infrastructure available to bioscience companies for their launch and growth. Whether you’re already here in our gorgeous state where the cost of living and doing business is low and the bio-talent is readily available, or looking from outside our borders to expand, Michigan has everything to offer and your company to gain. Simply contact me at

C O N TA C T I N F O R M AT I O N Physical Address

srapundalo@michbio.org and let MichBio, the state’s bioscience industry association show

3520 Green Court, Suite 450

you how to access the information, resources and assistance needed to make your venture

Ann Arbor, Michigan 48105-1579

a success here in Michigan.

Mailing Address P.O. Box 130199 Ann Arbor, Michigan 48113-0199 Stephen Rapundalo, Ph.D. President and CEO, MichBio

Check out

Phone

Next Issue: FALL 2010 Digital BioMatters

734.527.9150 Fax

BioMatters is now available in digital and print formats. Digital BioMatters is clickable, magnifiable, printable, linkable, savable and sendable, and it offers advertisers an array of tools that are not available in print. These include:

734.302.4933

• Direct links to your website and email addresses

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• The ability to include customizable forms so readers can request more information • The ability to include interactive media and video content

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General Information

• Expanded reach to a broader distribution list Digital BioMatters is distributed to MichBio’s database of 7,000 targeted email addresses, and it is always available on the MichBio website (www.michbio.org).

Be sure to pass it along to your own customers and constituents, and help us spread the word about Michigan’s robust biosciences industry.

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info@michbio.org

BioMatters | Spring 2010

C O R P O R AT E S P O N S O R S

P L AT I N U M

O F F I C E R S , D I R E C T O R S A N D C O M M I T T EE S

Executive Officers Chairman Stephen Munk, Ph.D. Ash Stevens, President and CEO President and CEO Stephen T. Rapundalo, Ph.D. MichBio, President and CEO

GOLD

Secretary Christina DeHayes Asterand plc, General Counsel

S I LVE R

Treasurer Matthew L. McColl Ernst & Young LLP, Partner ssistant Treasurer A Ryan Noel Division of Metabolism, Endocrinology and Diabetes, University of Michigan Administrator

Directors Linda Chamberlain, Ph.D. West Michigan Science & Technology Initiative Executive Director

BRONZE

David Felten, M.D., Ph.D. Beaumont Hospitals, Research Institute Vice President, Research and Medical Director J. Patrick Elliott Terumo Cardiovascular Systems Corp.

Vice President, Business Development James Freeman, Ph.D. Pfizer Animal Health Vice President, Laboratory Sciences

MEDIA

PATRON

Ash Stevens, Asterand, Lumigen, Varnum

FRIEND

Phadia US, Inc., Wayne State University

SUPPORTER

Biotechnology Business Consultants, Caraco, sanofi-aventis U.S., West Michigan Science & Technology Initiative

BioMatters | Spring 2010

Ricardo (Richard) Fuentes Jr. Dow Corporate Venture Capital Global Life Science Investment Director Teri Grieb U of M Medical School, Office of Research Director of Administration for Research Office of Research and Graduate Studies Mark Kielb Altarum Institute Chief Financial Officer

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Barry Klein GlaxoSmithKline Director, Market Development Michael Kurek, Ph.D. Biotechnology Business Consultants Partner/President Paul Morris AlixPartners, LLP Finance Manager, National Enterprise Improvement Practice Stephen Munk, Ph.D. Ash Stevens, President and CEO Stephen T. Rapundalo, Ph.D. MichBio, President and CEO John J.H. Schwarz, M.D. Family Health Center Physician, Former U.S. Representative Eric Stief Wayne State University — Technology Commercialization Licensing Manager Director of Venture Development Karen Studer-Rabeler Coy Manufacturing/ Coy Laboratory Products General Manager Vice President, Business Development David Zimmermann Kalexsyn, Inc. Chief Executive Officer

Committees Facilities Intellectual Properties and Legislation Marketing and Communications Membership and Services Programs Public Policy

Where science gets down to business

速

We assist in advancing the commercialization of innovative ideas and products. We develop collaborations to support high-tech, high-growth businesses. We provide connections that bring together people to spark entrepreneurial opportunities.

We Offer: Entrepreneurial support services, guidance with ideation and launch conceptualization, medical device/life science/technology incubator space, and access to funding, from seed grants to A-round investment.

For More Information Contact: Tel 616.331.5840 | wmsti.org | wmsti@gvsu.edu

BioMatters TA B L E O F C O N T E N T S

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MichBio Corporate Sponsors, Officers, Directors and Committees

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Feature Story: Venture Capital Support for Bioscience Grows in Michigan Investor Sees Potential Growing for VC Backing of Michigan Bio Projects

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Ecotek Shows Students the “World” of Science

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Michigan House and Senate Appoint Legislative Groups to Focus on the Bioscience Industry

Clinical Trials Tax Credit Could Benefit Michigan Labs

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ENTREPRENEURS:

Entrepreneurship

Thrives in ECONOMIC Michigan DEVELOPMENT: BioArbor Gives Entrepreneurs The Five Fingers a Place to Network and Learn of Michigan’s “Upper Hand” Advantage Innovator of the Year Finds

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EDUCATION: Students Thrive in Michigan Science Education Programs

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Michigan to Host World Stem Cell Summit

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Renewable Resources to Replace Petroleum-Based Products

32

The Right Place

Southwest Michigan First

TechTown

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Kalamazoo Makes Sense for Seneca Medical

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Guest Opinion: AcademicIndustry Partnerships: Reaching Out, Reaching In

What’s So Good About Doing Bio-Business in Michigan?

PROFILE: Neogen Plots Course for Continued Success in Food, Animal Safety Industry

Medical Main Street Ann Arbor SPARK

DIRECTORY & RESOURCE GUIDE

44 47

The following MichBio members are featured in this issue of BioMatters: Accuri Cytometers, Ann Arbor SPARK, Apjohn Group, Arboretum Ventures, Asterand, Borgess Medical Center, ClinXus, Coy Laboratory Products, Esperion Therapeutics, CytoPherx, EXT Life Sciences, Global Clinical Connections, Grand Valley State University, Housey Pharmaceuticals, Hylant Group, Johnson & Johnson, Kalexsyn, Karmanos Cancer Center, Lumigen, Metabolic Solutions Development, Michigan Economic Development Corporation, Michigan State University, Molecular Innovations, Monteris, MPI Research, Oakland County Medical Main Street, Micromyx, NanoBio Corporation, NanoSystems, Oxford Biomedical Research, Pfizer, QuatRx Pharmaceuticals, Quest Research Institute, RealBio Technology, Southwest Michigan First, Southwest Michigan Innovation Center, Southwest Michigan Life Science Fund, TechTown, Terumo Cardiovascular Systems, University of Michigan, Van Andel Institute, Vesteron, Wayne State University.

Subscribe to BioMatters:

Visit www.michbio.org and click “Register Now” or call 734.527.9150.

A D VE R T I S E R S Ann Arbor SPARK .................................................. 12 Ash Stevens .............................................................. 46 Bank of Ann Arbor .................................................. 24 Calibrate................................................................... 42 DBA Analytical......................................................... 41 Doeren Mayhew....................................................... 18 Dykema.................................................................... 42 Great Lakes Entrepreneur’s Quest .......................... 24 Golden Limo ............................................................ 46 Grand Valley State University.................................. 24 Healthmark.............................................................. 46

Hylant Group............................................................ 31 Kettering University ................................................ 19 Michigan Economic Development Corporation.... IBC MichBio .................................................................. BC Michigan State University ....................................... 21 Microbiological Associates ..................................... 42 Midwest Cleanrooms .............................................. 46 MPI Research .......................................................... 27 NuStep ..................................................................... 31 Oakland University.................................................. 33 Pfizer........................................................................... 6

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PhRMA..................................................................... 68 Plas Labs................................................................. IFC Radar Fishman & Grauer ....................................... 31 RS Electronics ......................................................... 33 The Brooks Industrial Park....................................... 2 University of Michigan ........................................... 30 Varnum Law............................................................. 33 Wayne State University............................................ 36 West Michigan Science & Technology Initiative ......5 Western Michigan University.................................. 41

BioMatters | Spring 2010

F I N A N C I A L M AT T E R S

F E AT U R E S TO RY

Venture Capital Support for Bioscience Grows in Michigan

BioMatters | Spring 2010

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The recipe for economic growth and innovation often calls for a heaping portion of venture capital, dollars put up by investment firms whose job is to search out The Next Big Thing, nurture it, guide it, and hopefully eventually profit from it.

One of every 10 jobs in the U.S. was created from either a currently or previously venture-backed company, and those firms represent 19 percent of the country’s gross domestic product.

By Tom Beaman After years in the minor leagues, Michigan is becoming a popular destination for venture capital as firms acknowledge the state’s robust university research community, its highly skilled workforce, and especially, its track record in the bioscience sector.

“Michigan’s been making some progress over the last years,” says LeAnn Auer, executive director of the Michigan Venture Capital Association. “We started in 2001 with seven venture capital firms headquartered here and now we have 16. The amount of capital under management is now over $1 billion, twice as much as in 2001.”

Auer says California and Massachusetts traditionally claim 60 percent of the country’s available venture funding, but Michigan is making impressive strides. In terms of the total amount of venture capital invested in the state, Michigan ranked 14th in 2008, up from 25th in 2007.

Michigan is becoming a popular destination for venture capital as firms acknowledge the state’s robust university research community, its highly skilled workforce, and especially, its track record in the bioscience sector.

The MVCA says $1.3 billion in demand for venture capital funding existed in Michigan in 2008, and of the 14 Michigan-based firms, 12 invest in life science fields. “If you

Venture-backed HealthMedia, Inc., a University of Michigan spin off, provides Web-based health coaching technology. The company was acquired by Johnson & Johnson in 2008.

break down that $1.3 billion, half of it came out of biotechnology, medical technology, and healthcare services,” says Auer.

100:1 Ratio The courtship between venture capitalists and entrepreneurs involves a complex mating dance that often results in the venture being rejected. Chris Rizik, who runs the $40 million Renaissance Venture Capital Fund at Ardesta LLC in Ann Arbor, says a VC firm typically looks at 100 prospects before it is convinced to open its wallet. There are some obvious traits, however, that make a firm attractive to investors.

“You certainly look for a company that is going to fulfill a need out there that isn’t currently being met,” says Rizik. He points to Ann Arbor-based HealthMedia, Inc., a University of Michigan spin-off whose Web-based health coaching technology helps companies lower healthcare costs and improve wellness. HealthMedia opened its doors in 1998 with support from VC firms in Kentucky and Michigan, and was acquired

by Johnson & Johnson in 2008 for an undisclosed sum.

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For Michael Gross, managing director at Beringea LLC in Farmington Hills, whose $100 million InvestMichigan! Growth Capital Fund portfolio includes Accuri Cytometers and Pioneer Surgical Technology, Inc., key factors include the size of the market opportunity, the differentiation of the product or service, and the experience of the management team. “We like to see entrepreneurs who are experienced in the space in which they’re building their company and ideally have a track record of building previous companies,” Gross says.

$1.3 billion in demand for venture capital funding existed in Michigan in 2008—half of it came out of biotechnology, medical technology, and healthcare services HandyLab Meets the Need Jeff Williams, a prominent Michigan entrepreneur who has held executive posts in Genomic Solutions, Inc. and HandyLab, Inc., and is currently president and CEO of Accuri Cytometers, Inc., says he looks for evolutionary technology that solves a major unmet need, but is not so radical that it takes a long time to adopt. He found that formula in HandyLab, Inc., an Ann Arborbased clinical diagnostics company that was founded in 2000 by two University of Michigan Ph.D. candidates.

BioMatters | Spring 2010

F E AT U R E S TO RY

“HandyLab’s technology uses nucleic acid amplification to test for infectious diseases like influenza, STD’s and MRSA,” says Williams, who joined the company in 2004. “Their technology enables you to do that faster with a fully automated, compact system that’s easy to use. Hospitals can run tests themselves and get the results much more rapidly.”

After beginning life in 2000, with over $40 million in backing from several venture capital firms and Pfizer, Inc., HandyLab was acquired by Becton Dickinson and Company in 2009 for $275 million.

Sometimes it’s whom you know as much as what you know that results in a success-

“I came here to take advantage of my network in both biotech and molecular diagnostics to help put Grand Rapids on the map for biotechnology.”

The Center

Molecular Medicine in Grand Rapids Spectrum Health and the Van Andel Institute. The company was acquired by Sequenom in 2008. for

was originally a joint venture of

ful marriage in the biotech world. In 2006, Daniel H. Farkas, Ph.D., HCLD, a nationally recognized leader in the field of molecular diagnostics, was hired to run the Center for Molecular Medicine, a joint venture of Spectrum Health and the Van Andel Institute in Grand Rapids.

Putting Grand Rapids on the Map “I didn’t want to come to Grand Rapids just to build another Chlamydia lab,” says Farkas, who has established DNA diagnostics facilities in New Jersey, Michigan and Texas. “I

Michigan-Based BIO-FOcused Venture Capital Firms

The

came here to take advantage of my network in both biotech and molecular diagnostics to help put Grand Rapids on the map for biotechnology.”

Farkas’s strategy was to leverage the city’s already impressive medical establishment, which included the Fred and Lena Meijer Heart Center and the Lemmen-Holton Cancer Pavilion, to attract additional investment to the region. “We have an outstanding research facility in the Van Andel Institute and a magnificent healthcare system embodied in Spectrum Health. They were interested in bringing new jobs and opportunities to town,” he says.

Mining his considerable professional network with the fervor of a civic leader (“Just come here and take a look,” Farkas would tell skeptical colleagues.), he sang the region’s praises. “We got Canon, Qiagen, and Siemens to show up,” he says. “We got the attention

number of venture capital

Michigan 2001, according to LeAnn Auer, executive director, Michigan Venture Capital Assoc. firms headquartered in

n Apjohn Group, LLC – www.apjohnventures.com

has doubled since

n Arbor Partners – www.arborpartners.com n Arboretum Ventures – www.arboretumvc.com n Ardesta, LLC – www.ardesta.com n Beringea – www.beringea.com n BioStar Ventures – www.biostarfund.com n Bridge Street Capital - www.bridgestreetcapital.com n EDF Ventures – www.edfvc.com n North Coast Technology Investors – www.northcoastvc.com n Oracle Capital Partners - www.oracle-capital.com n Plymouth Management Company www.plymouthvc.com n Renaissance Venture Capital Fund - www.renvcf.com n Seneca Partners – www.senecapartners.com n Southwest Michigan First Life Science Fund – www.southwestmichiganfirst.com n TGap Ventures – www.tgapventures.com

Venture Firms with Fullor Part-time Staff in Michigan n Chrysalis Ventures www.chrysalisventures.com n Early Stage Partners - www.esplp.com n Fletcher Spaght - www.fletcherspaght.com n Triathlon Medical Venture Partners - www.tmvp.com n Venture Investors - www.ventureinvestors.com

n Wolverine Venture Fund – www.zli.bus.umich.edu/wvf

BioMatters | Spring 2010

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“We are definitely on the map and should be noticed by those who are interested in investing in biotech.” of a lot of folks, including Sequenom, who knocked on my door in July 2008 and said, ‘We want to buy your lab.’” The $4 million deal was finalized in November 2008.

When the purchase was announced, David Van Andel, chairman and chief executive officer of the Van Andel Institute, said, “Sequenom and the Van Andel Research Institute have a shared vision – to move important scientific findings from research laboratory to clinical laboratory to patients.

CMM was created to leverage new technologies for the purposes of Dan Farkas’ fervor more precise treatment for the Grand Rapids options for patients and, region and his Center for Molecular Medicine through this acquisition is infectious. It

by Sequenom, and our attracted Sequenom to the region, bringing research collaboration, jobs and investment into the community. this goal can be realized more immediately.”

Dan Farkas, Sequenom Center for Molecular Medicine.

“We have a lot of the tools and raw materials that can attract biotech companies to this region.”

Photo courtesy of Sequenom Center for Molecular Medicine

Farkas has high hopes for Michigan, which he says he loves. “We have a lot of the tools and raw materials that can attract biotech companies to this region,” he says.

“Commercial real estate is cheap, we have a lot of skilled engineering and manufacturing labor, and we have a lot of intellectual capital in our universities. We are definitely on the map and should be noticed by those who are interested in investing in biotech.”

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BioMatters | Spring 2010

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I also call it home. The place where my company can thrive and expand. And the place where start-ups have every advantage. That includes superb laboratory space. A long list of business amenities. And—perhaps most important— peer-to-peer mentoring that connects them with experienced entrepreneurs on a daily basis.

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Contact Greg Fronizer, at 734.761.9137 or Greg@AnnArborUSA.org.

F E AT U R E S TO RY

Investor Sees Potential Growing for VC Backing of Michigan Bio Projects

Fletcher Spaght Ventures (FSV) is looking for a few good

and unwanted lesions, was developed in laboratories at the

companies. The Boston-based venture capital fund has been

University of Michigan. The first clinical application of histo-

scouring the entrepreneurial landscape for nine years, dip-

tripsy will be the treatment of benign prostate hyperplasia,

ping into its $100 million-plus pool of cash when it discovers

and it’s expected to revolutionize ultrasound therapy.

a promising start-up. The firm specializes in emerging high

technology and healthcare companies and has backed start-

The state is fifth in the number of patents awarded, eleventh in National Institutes of Health funding, second in industrial R&D spending, and ninth in government research funding.

ups from Massachusetts to California, but it also sees Michigan as fertile ground for its investment dollars.

“The potential for Michigan is there, that’s for sure,” says

John Fletcher, the founding partner of FSV. “In the last four to five years, at least half of the companies that have been funded by venture capital in Michigan have been in biotech, medical devices, equipment, and healthcare services.”

Fletcher says Michigan ranks highly in many categories,

Though a relative newcomer to the industry, HistoSonics

and this suggests enormous potential. The state is fifth in the

“has a CEO, a medical advisory board, a product development

number of patents awarded, eleventh in National Institutes of

team, and they’re creating jobs,” says Fletcher.

Health funding, second in industrial R&D spending, and ninth

in government research funding.

Despite its impressive track record to date, Michigan still

trails life science megaplayers like California. It ranks twenty

second in total venture capital invested and thirty-eighth in venture capital invested per patent awarded. But Fletcher

The potential for Michigan is there, that’s for sure,” says John Fletcher, the founding partner of FSV.

says given time and the proper support, Michigan can compete with any state, or even countries like Ireland, which boasts a thriving bioscience industry that employs 40,000 people.

“It takes some time to build up a critical mass in all of

these centers of expertise, but it can be done,” says Fletcher.

“What this says is that there is a lot of money going into high

“Michigan’s on the front end of that process and doing an ex-

quality research and development in life sciences in the state

cellent job. The state has launched many innovative programs

of Michigan,” he adds.

that are fundamental to building a strong venture capital com-

munity. The benefits could be tremendous.”

Fletcher Spaght Ventures, along with three other venture

capital firms, invested $11 million in HistoSonics Inc., an Ann Arbor-based start-up whose histotripsy technology, which uses focused sound waves to non-invasively break up tumors

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BioMatters | Fall 2009

education

Students Thrive in Michigan Science Education Programs

By Tom Beaman

The country’s educational infrastructure faces tremendous hurdles, but amidst the challenges there is cause for hope, especially for students aiming for a career in the biosciences, starting right here in Michigan.

“There is an increased rigor in science courses with the new Michigan state curriculum,” says Robby Cramer, executive director of the Michigan Science Teachers Association and science education specialist with the Van Andel Education Institute (VAEI) in Grand Rapids. “All students must take biology in high school...and they must have at least three years of science in high school.”

Cramer sees more students taking advanced placement biology courses, and she is encouraged by the results. “Michigan is six percentage points above the national average and ranks ninth in the nation in the number of students passing AP science courses with a score of three or higher. In AP biology courses we are ranked tenth in the nation.”

MichBio President and CEO Stephen

BioMatters | Spring 2010

If educators in Michigan agree on anything, it’s that science education – and the resulting igniting of passion for the sciences in young minds – will only succeed if kids get a taste of the real thing.

Rapundalo, Ph.D., agrees, but is pushing for more: “Across the board, there has been a higher level of achievement in the sciences, but I think we have to do more to expose kids to hands-on experience in biotechnology,” he says. “It ties scientific theory to the real world in a way that they can better understand. And the more they can relate with, the more they appreciate the diversity of career paths and opportunities possible in the biosciences.”

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Success = engaged Rapundalo is not alone in his beliefs. If educators in Michigan agree on anything, it’s that science education – and the resulting igniting of passion for the sciences in young minds – will only succeed if kids get a taste of the real thing. The word most often heard during these discussions is “engaged.”

A soon-to-be-published study by the Van Andel Institute indicates that 80 percent of elementary students are excited by science, but by the time they reach middle school and high school, two thirds have lost interest. “We believe...they’ve lost their motivation to study science, in part, because they haven’t engaged in it,” says Marcia Bishop, associate director of the Van Andel Education Institute.

At the Macomb Mathematical Science and Technical Center in Armada, students participate in a year-long research project that culminates with a presentation before the whole school

Photo courtesy of Macomb Mathematical Science and Technical Center

during which they must defend their work.

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BioMatters BioMatters || Spring Spring2010 2010

Photo courtesy of Van Andel Education Institute

education

A critical component of science education programs at the Van Andel Education Institute in Grand Rapids is that the students see themselves as scientists conducting research, working in teams, recording data and reporting their findings.

“In classrooms where students are engaged actively in doing science, science is cool,” says Paul Drummond, science consultant and co-director of the Macomb Mathematics Science and Technical Center in the Macomb Intermediate School District.

But before students can be engaged, teachers must be engaged, and that’s easier said than done. Bishop cites recent Van Andel and National Science Foundation studies that found that elementary school teachers feel unqualified to teach science due to a professional development focus on math and language arts; the lack of time, resources, or space; or insufficient science training in college.

Three years, 300 hours In an effort to sharpen science teacher qualifications, the VAEI offers the “Partners for Sustainable Innovation” program through its Science Academy. The program partners middle school teachers from the Grand Rapids area with life science professionals at hospitals and universities. Over a three-year period, teachers receive 300 hours of professional development aimed at deepening their understanding of scientific concepts, health and life science careers, and

BioMatters | Spring 2010

the use of inquiry-based learning to engage students in science. “[The program] will not only improve the effectiveness of science teachers to educate the future life sciences workforce, but will also spark student interest in science, leading more of them to science-related careers,” says Bishop.

Another Science Academy offering, the “Out-of-School-Time Cohort Program,” teaches fourth and fifth graders to think and act like scientists. For three consecutive years, Grand Rapids-area students conduct research based on hypotheses, work in teams, record data in lab books, and report their findings to each other and larger audiences.

“Students in all of our programs are actively engaged in questioning, predicting, observing, evaluating, explaining, and making claims based on the evidence they found,” says Bishop. “The critical component is that they see themselves as scientists.”

“Value outside the sciences” Students are being turned on to bioscience on the other side of the state as well. At the Macomb Academy of Arts and Sciences in Armada, Michigan, some 200 students spend four intensive years studying calculus,

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computer science, forensics, and biology, all at honors levels.

“Our big activity is a yearlong research project,” explains Ron Blume, a science teacher at the school which is known by its exponential acronym MA2S. “We analyze the

“The feedback we’ve received from kids who’ve gone off to college, regardless of whether they’ve entered the science field, was that [their research project] was one of the most valuable things that they did” data for a month, and then we start them on the process of writing a scientific paper. They create a presentation and they have to defend their work in front of the whole school.”

Among the student research projects produced at MA2S in 2009 were “The Effect of Antimicrobial Content in Polyethylene on the Prevention of Bacterial Growth” and “The Effect of Hydrogen Peroxide on the Immunity of Escherichia Coli.”

“The feedback we’ve received from kids who’ve gone off to college, regardless of whether they’ve entered the science field,

education

Ecotek Shows Students the “World” of Science

Amber Young has done research on aortic aneurysms,

traveled to South Africa to study climate change, and met with members of the United Nations’ World Health Organization to discuss ways to improve access to healthcare and prevent common illnesses that arise from unsanitary conditions.

Amber Young is 11, and in the sixth grade.

Amber, who attends the Detroit Edison Public School

Academy, is also one of 15 “student scientists” currently enrolled at Ecotek, a branch of the Motor City Model U.N. Club, whose aim is to give students a better understanding of the way science shapes international policymaking. From its labs in Detroit’s TechTown business incubator, Ecotek students get a deep-dive, hands-on experience with some of the hottest scientific topics: environmental science, alternative energy, molecular/material science, and biotechnology.

With guidance from Ecotek founder Keith Young and

visiting guest scientists, the students, who range in age from 11 to 17, identify and research global issues, design research projects around those issues, and report their results to U.N. Photo courtesy of Ecotek

leaders and other scientists around the world. “Ecotek is enhancing science in Michigan by connecting science research to global issues,” says Young. “Our students work on a wide range of projects with member countries at the United Nations. They also do a lot of hands-on field work with world renowned researchers. Ecotek is setting the bar for science education in Michigan.”

Keith Young (front), founder of Ecotek, is enhancing and complementing Michigan’s science education programs by connecting science research to global issues.

In the bioscience area, one project involved understanding

how to deliver drugs to people in developing countries at a low cost. “We’re working with our kids on nanochemistry so they

can understand how synthesis works and how you can apply it

student scientists are eligible to attend special life science programs

to drugs as far as being able to break it down into small enough

at top schools across the country. Five students will attend the

particles that it could be delivered in a controlled dose - and

University of Michigan’s advanced chemistry program this summer;

more important, reduce the cost of delivery.”

others, like Amber Young, will participate in the university’s six-week

In addition to working on bioscience projects in the lab, Ecotek

Mini Med School program. “I hope to work with different doctors

“Our students work on a wide range of projects with member countries at the United Nations. They also do a lot of hands-on field work with world renowned researchers.”

that can help me become a pediatric neurosurgeon,” she says.

Young believes the Ecotek program is vital to the development

of future scientists, and that it fills a void that exists in the school system.

“If it was my child, to what level of depth would I go to insure

Ecotek students have also studied the relationship of air

the quality of that experience sticks and is actually momentum for

quality in developing countries to the incidence of lung cancer

them going into the future,” he says. “I have these kids compete

and how to determine whether cardiovascular disease is

in national and international competitions outside of Michigan and

based on heredity or lifestyle. One team of student scientists

outside of the U.S. to see how they fare in an open environment.”

recently made biodiesel out of soybean oil, and researched

methods of converting algae and other cellulose-based materials

in terms of whether or not we receive accolades from the school

to biofuel. Young led a team to New York this spring to share

system or from the state of Michigan, for that matter. I measure

their research findings with the World Health Organization and

success by the actual students and what they do.”

Is Young’s Ecotek program a success? I don’t measure success

to learn what the WHO is doing to help address these illnesses on a global scale.

17 19

BioMatters | Spring 2010

education

was that that was one of the most valuable things that they did,” says Blume. “It taught them how to gather data...and to be able to write and defend their work. It has value even outside of the sciences.”

Blume believes that the biosciences have a particularly bright future because they impact people’s lives. “Maybe there’s going to be a bio-engineered organism that’s going to scrub CO2 out of the atmosphere or...that can consume toxic spills,” he says. But Blume also believes strongly that science education must be radically re-thought if kids are to be successfully “engaged.”

“This is our future bioscience workforce... It’s not enough to focus on the current one.

We have to be prepared to ensure that there is a steady pipeline of talent…”

BioMatters | Spring 2010

A Van Andel Institute

study indicates that

elementary students are excited by science. to make it stick.

80% of The key

is

“In the standards set forth by the politicians, the emphasis has been turning our kids into walking encyclopedias, so therefore science is something that you memorize as a bunch of facts and not something that you do,” he says. “We need to get from science as a noun to science as a verb, and I think our research project does that.”

Bioscience, up close and personal Hundreds of students have received up close and personal encounters with the bioscience industry by attending the high school career

18

days and college programs that run as part of MichBio’s annual Expo. At the 2009 Expo at Western Michigan University in Kalamazoo, students toured the University’s biological imaging center and molecular modeling lab. They also learned about projects involving biomechanical research and neurobiology.

“This is our future bioscience workforce,” Rapundalo says. “It’s not enough to focus on the current one. We have to be prepared to ensure that there is a steady pipeline of talent…that means staying abreast of the latest technologies, techniques and instrumentation that can be applied in biotech research of the future. We try to expose these kids and make them aware that the biosciences are much more than the traditional career paths of medicine and nursing. You can customize your career to suit your own interests, skills and passion.”

Derek Hazard ‘11 Applied Physics and Applied Math Co-op: Umicore AutoCat

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BioMatters | Spring 2010

Michigan—through its voters and its research—showed the world its commitment to stem cell research.

Now the global community of stem cell researchers will make Michigan its world stage.

Michigan this fall hosts the prestigious World Stem Cell Summit, produced by the Genetics Policy Institute (GPI). The sixth annual summit (co-hosted by the University of Michigan, Michigan State University, Wayne State University, and the Michigan Economic Development Corporation) will be held October 4-6 at the Renaissance Center in Detroit.

“The Genetics Policy Institute selected Michigan because the state is the anchor of stem cell research in the Great Lakes region, home of world-class research institutions and dedicated to advancing the regenerative medicine industry,” Bernard Siegel, executive director of GPI, explained.“In addition, the citizens of Michigan voted to protect stem cell research in the state’s constitution. That sent a message that Michigan is committed to advancing scientific research for cures.”

More than 1,200 participants from 40 states and 30 countries will attend the summit. It will cover all areas of stem cell

BioMatters | Spring 2010

The

annual

World Stem Cell Report

assists leaders

and decision makers to stay abreast of the latest developments relating to stem cells. www.worldstemcellsummit.com.

Download

it at

science, disease models, drug discovery, tissue engineering, bioreactors and nanotechnology. Experts will present progress reports on treatment for cancer, diabetes, spinal

20

cord injury, multiple sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), neurological disorders and cardiovascular disease. There will also be panel discussions on funding, commercialization, economic development, law, ethics and regulatory agency perspectives.

“Hosting the summit is an amazing opportunity for Michigan,” said Sheri Mark, president of the Board of Directors of Michigan Citizens for Stem Cell Research and Cure.

“This shows the world that Michigan is a very stem-cell-research-friendly state. We have world-class research universities here, and a lot of new businesses in the field of life sciences are interested in locating to Michigan.”

Michigan State Senator Gretchen Whitmer believes that the World Summit will bring global attention to Michigan’s role in stem cell research. “This event will showcase the research going on in our state and demonstrates that Michigan is going to be in the

Photo courtesy of the California Institute for Regenerative Medicine

Michigan to Host World Stem Cell Summit

race for cures,” she remarked. “It’s exciting to have the world’s attention on an issue that means so much to so many people.”

Each of the three universities co-hosting the summit – Michigan State University, the University of Michigan, and Wayne State University – will have a summit chair to represent its institution. “Being a co-host will be an outstanding opportunity to highlight not only stem cell research currently underway at Michigan State University, but also the major research contributions from the University of Michigan and Wayne State,” J. Ian Gray, vice president of research and graduate studies and Michigan State University, said. “Stem cell research offers great hopes and expectations for understanding the mechanisms of deadly diseases and possible cures. With the talented researchers at Michigan universities, Michigan will play a major role in effecting change in how we treat and, hopefully, cure such diseases.”

Detroit

takes the world stage

Oct. 4-6

when the city plays host to the

Similarly Steve Forrest, vice president of research at the University of Michigan, sees “a tremendous opportunity for Michigan researchers to share ideas and novel science that will impact stem cell research in the decade ahead.”

Stephen Rapundalo, Ph.D., president and CEO of MichBio, believes that this is a pivotal time for regenerative medicine with a great potential for new discoveries to be commercialized. “The economic impact of this Summit for Michigan is huge, and is likely to afford an opportunity for startup ventures in the stem cell field to launch or

World Stem Cell Summit.

expand in our state,” he said.

Hilary Ratner, vice president for research at Wayne State University, concurred. “Stem cell research holds tremendous potential, and the University Research Corridor (URC) and Michigan are well positioned to be a major hub for advancing research in this area,” she said. “Our Stem Cell Commercialization Center, located at TechTown, our research and technology park, will provide significant resources and opportunities to accelerate the discovery of stem cell-based therapies, while at the same time stimulating Michigan’s economy in new directions.”

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BioMatters | Spring 2010

D ATA

MI Bio-Industry Quick Facts

Academic Bio-Research University Research Corridor

Bio-Industry Investment, Commercialization Resources & Incentives

40,086

Total R&D:

$323 million

# Spin-Off Jobs:

(#11 best in the nation)

# Bio Companies & Organizations:

>525

# Bioscience Jobs:

58,721

$1.4 billion Biosciences R&D:

Average Bioscience Salary:

$916 million

Total Payroll:

# of Biosciences Degrees:

$73,390

$2.5 billion Economic Impact:

(#10 best in the nation)

4,721

(#8 best in the nation)

$9.5 billion

# of Bioscience-Related Patents:

Total Bioscience Start-Ups Since 2002:

(2002-07)

122

BioMatters | Spring 2010

2,225

22 24

Life Sciences Corridor Fund – 21st Century Jobs Fund: (1999-2009)

VC Investments:

$268.7 million (2002-07)

Total $ Raised:

$68.8 million

(#11 best in the nation 2009)

21st Century Investment Fund:

$109 million fund-to-funds $46 million to biosciences

a sample of Bioscience Companies in Michigan n Pfizer

n Housey Pharmaceuticals

n Dow Chemical

n Sequenom

n Neogen

n MPI Research

n Perrigo

n QuatRx Pharmaceuticals

n NanoBio

n Genetics Squared

n Accuri Cytometers

n Somanetics

MI Pre-Seed Capital Fund

n Stryker

n Lumigen

n Vestaron

MI Microloan Fund

n Rockwell Medical

n Ferndale Labs

n Kellogg

Angel Investor Tax Credit

n Oxford Biomedical

n BD Diagnostics

n Terumo CVS

R&D Tax Credit

n JHP Pharmaceuticals

n Assay Designs

n Atek Medical

R&D and Bio-Manufacturing Tax Exemption

n Phadia

n Ash Stevens

NOL Carryover

n Pioneer Surgical

n Esperion Therapeutics

SBIR Match

n Asterand

n Kalexsyn

Venture Michigan Fund:

$95 million fund-to-funds

(2007-09)

Distribution of Michigan bio-companies by sector Pharma & Therapeutics

23%

Medical Devices/Equipment

35%

Research & Development

20%

Testing/Medical Labs

5%

Information Technology

7%

AgBio & Industrial Biotech

10%

AgBio & Industrial Biotech Information Technology

Pharma & Therapeutics

Testing/Medical Labs

Research & Development Medical Devices/ Equipment

23 25

BioMatters | Spring 2010

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BioMatters | Spring 2010

24

entrepreneur S

Entrepreneurship Thrives in Michigan An entrepreneurial culture has taken hold in Michigan, spurred by innovative biosciences professionals and supported by a robust network of business development organizations along with state programs and resources. Following is a snapshot of some entrepreneurs and their companies that illustrates a diversity of products and technologies that are being commercialized within the state.

By David L. Shenkenberg

Algal Scientific Corporation The idea for Algal Scientific was born during a father-son research outing on Lake Erie in 2008. Geoff Horst was sampling algae for his Michigan State University doctoral dissertation with his father, Paul Horst, currently an Entrepreneur-In-Residence at Rocket Ventures in Toledo, Ohio.

With a power plant on the lake’s western shore as inspiration, the two speculated on the ability of algae, some of the fastest

The company’s process uses proprietary algal strains and technology to scrub the wastewater and produce clean water and algal biomass.

growing life forms on earth, to clean up pollutants from industrial facilities. Those discussions led to the formation of a team with graduate students at the University of Michigan, which competed in and won the $65,000 Clean Energy Prize from the University of Michigan and DTE Energy as

25

well as a $5000 award from the university’s Frederick A. and Barbara M. Erb Institute.

The winning concept was to remove polluting nutrients such as nitrogen and phosphorus from wastewater that contribute to $4.3B in costs to society in the USA. The company’s process uses proprietary algal strains and technology to scrub the wastewater and produce clean water and algal biomass that can be turned into biofuels, fertilizer, and other valuable by-products.

BioMatters | Spring 2010

BioArbor Gives Entrepreneurs a Place to Network and Learn

entrepreneur S

Most of their business will be driven by EPA enforcement of the Clean Water Act. “The strict regulations that started on the East Coast are expanding across the country,” says Geoff.

When Julia Owens, Ph.D., moved from San Francisco to work as the

senior director of business development for QuatRx Pharmaceuticals in Ann Arbor, she wanted to build a local network of bioscience colleagues. Rather than searching out the occasional meeting or event, the energetic Owens gathered up a “think tank” of local professionals to plan monthly meetings, and BioArbor was born.

“We cover technology commercialization, financing strategies, team building, business development, regulatory affairs, marketing and more, all with a focus on the life sciences,” says Owens.

“Our goal at BioArbor events is to bring the local bioscience community

together on a regular basis, so that we can share ideas, build relationships and work together to foster new life sciences companies in the area,” said Owens.

Since its first official meeting in July 2007, the group has attracted a

loyal following of bio-entrepreneurs as well as students and other new-comers, with attendance averaging 70–80 people a month. More than 600 people

Algal Scientific’s proprietary algal strains not only scrub wastewater, but the resulting algal biomass can be turned into biofuels, fertilizer and other valuable by-products.

have attended events and are now on the group’s mailing list, and the group even has its own website (www.bioarbor.com).

“We cover technology commercialization, financing strategies, team build-

ing, business development, regulatory affairs, marketing and more, all with a focus on the life sciences,” says Owens. “The first hour of each event is all-out networking followed by a program and Q&A, which can be pretty lively.”

Speakers are often brought in from outside the local area and share

experiences on topics that are applicable to those in drug discovery & development, medical devices, diagnostics and tools. A popular recurring event, “The Good, the Bad and the Ugly,” has three or four experienced entrepreneurs sharing their successes and mistakes that others can learn

The company incorporated in May 2009 and conducts research at the Michigan Life Science and Innovation Center in Plymouth, MI. It received an investment from the Michigan Pre-Seed Capital Fund and others, and is continuing to raise funds for future demonstration sites. It has six part-time employees in addition to Geoff, who serves as Chief Science Officer, and Paul as interim CEO. (www.algalscientific.com)

from. BioArbor events are open to the public and are especially suited for those interested in starting or growing bioscience businesses.

EXT Life Sciences, Inc.™

A new product from EXT Life Sciences, Inc. of Detroit and Southfield, Mich., may bannish gray hair and remove unsightly wrinkles. Sound too good to be true? Time will tell. The company has developed a breakthrough cellular targeted antioxidant platform which can, for the first time, deliver needed protection to a specific compartment of human cells in order to control or eliminate oxidant damage.

Thanks to

sponsorships by local businesses, such as law firms and insurance companies, and support from MichBio and Ann Arbor SPARK, the meetings are free, which is appreciated by entrepreneurs.

A new product from EXT Life Sciences, Inc. of Detroit and Southfield, Mich., may bannish gray hair and remove unsightly wrinkles.

Julia Owens

of

QuatRx Pharmaceuticals

BioArbor

2007

wanted a way to

connect with local bio-entrepreneurs, so she formed

BioMatters | Spring 2010

in

and continues to lead the successful group.

The product is a proprietary enzyme called CATSKL™, which is based on the naturally occurring antioxidant, catalase.

CATSKL™ originated from the collaborative research of scientists at the Wayne State University School of Medicine in Detroit, and the University of Western Ontario in London.

Because antioxidants have been shown to be integral to the fight against various diseases inside the body, the product also could have pharmaceutical applications, although the company plans to target cosmeceutical applications first, before moving onto pharmaceutical testing.

“We’re at a point where we have an effective molecule that tests have shown can act without toxicity,” said John Tesija, JD, vice president and head of operations at EXT. The company plans to partner with other firms to develop and market its products in both the cosmeceutical and pharmaceutical fields. (www.extlifesciences.com)

RealBio Technology’s Culture System

facilitates

the growth of in vitro cultures in a manner mirroring natural in vivo cell and tissue development beyond the limitations of current

2D

3D

and

technologies.

“What makes us unique is that the technology was formed in Michigan, manufactured in Michigan and commercialized in Michigan.”

RealBio™ Technology RealBio Technology, Inc. was founded when Paul Neeb, working as an Executive in Residence with the SWMF Life Science Fund, sorted through various early stage projects and found one that inspired him.

The project that Neeb, an M.B.A. from Northwestern University’s Kellogg School of Management, found was a 3D chamber for growing stem cells developed by Aastrom Biosciences in Ann Arbor under a grant from the Defense Advanced Research Projects Agency. The chamber was originally designed to sustain human bone marrow.

“What makes us unique is that the technology was formed in Michigan, manufactured in Michigan and commercialized in Michigan,” Neeb, now RealBio’s President and CEO, said.

Typically cells used in biomedical research are grown on a flat Petri dish rather than in a chamber that allows the cells to grow in 3D as they would in the human body.

The 3D chamber sold by RealBio Technology is ‘bio-realistic’, that is, closely resembles the in-vivo environment for cell growth.

Funded in part through the SWMF Life Science Fund, RealBio Technology has

Resourceful Direction for Drug Development MPI Research understands the complexities often associated with drug development decisions, and partners with Sponsors in finding innovative solutions to their development challenges. The comprehensive services offered by MPI Research include: Drug Safety Evaluation • General Toxicology • Developmental and Reproductive Toxicology • Infusion Toxicology • Safety Pharmacology • Neurobehavioral Sciences, including Abuse Liability Resource Services • Clinical Pathology • Histopathology • Regulatory Submissions Publishing (eCTD) • Consulting Services (IND preparation and filing)

Corporate Headquarters 54943 North Main Street Mattawan, MI 49071-9399 USA +1.269.668.3336 www.mpiresearch.com

Discovery Services • Experimental Therapeutics • Experimental Surgical Models • Molecular Imaging • Immunology • ADME/Pharmacokinetics Bioanalytical/Analytical Sciences • Method Development • Validation to Support Small and Large Molecule Therapeutics Medical Device Evaluation • Regulatory Guidelines (ISO 10993) • Interventional Device Evaluation • Surgical Device Evaluation • Other Models

MPI Research is a global Contract Research Organization (CRO) that performs preclinical and select clinical studies for biotechnology, pharmaceutical, and medical device companies. The company partners with its Sponsors in moving their test candidates along the regulatory pathway, in an effort to bring better, safer medications and medical products to the world.

27

BioMatters | Spring 2010

entrepreneur S

developed the RealBio Culture System; a disposable cell culture technology offering significant advancements beyond current 2D and 3D technologies. It is the first commercially available culture system that enables cells to migrate out of the culture, which allows the culture to be maintained for a long period of time. (www.realbiotechnology.com)

Wellness Indicators Inc. Although antioxidants have been shown to fight diseases in humans, there is currently no convenient way for people to determine whether they are receiving a beneficial level of antioxidants from dietary supplements and foods.

Wellness Indicators Inc., of Rochester Hills, Mich., is developing testing supplies that can measure biomarkers for oxidative damage, antioxidant capacity and inflammation (another major risk factor for multiple diseases) in human urine. Initially the tests will be administered in clinical settings such as a doctor’s office, according to company CEO, Denis Callewaert, Ph.D. Before founding Wellness Indicators, Callewaert founded several other companies, including Oxford Biomedical Research, where he is currently CEO. He built his businesses gradually with National Institutes of Health Small Business Innovation Research grants while a professor at Oakland University.

Wellness Indicators Inc., is developing testing supplies that can measure biomarkers for oxidative damage, antioxidant capacity and inflammation in human urine.

For Wellness Indicators, Callewaert received an initial angel investment that included valuable resources for building the business plan and investor materials. The company is in the process of completing a $500,000 private placement and is seeking venture capital. Eventually, he hopes to

BioMatters | Spring 2010

Azenic Dental

received

FDA approval

to market its

disposable high-speed drill, answering the call for dental instruments that protect patients from cross contamination.

step down as CEO of Wellness Indicators and become CTO or CSO. (www.wellnessindicators.com)

company, CytoPherx, was founded in 2007 and aims to significantly reduce mortality from acute kidney failure with a medical device that significantly reduces the body’s inflammatory response.

The device attaches to a kidney dialysis machine, collects and deactivates activated white blood cells that are causing a dangerous systemic inflammatory response. It originated from the research of Dr. H. David Humes at the University of Michigan Medical School.

Azenic Dental, Inc.™ Azenic Dental, Inc. is a device company focusing on meeting dental market needs in the area of disposable instruments.

Co-founded in 2005 by the Apjohn Group, a Kalamazoo-based life-sciences business consulting company, Azenic very quickly met significant milestones in staffing, fundraising, product design and development.

In February 2008, Azenic received U.S. Food and Drug Administration clearance to market a new, patented disposable high-speed dental drill, the Azenic DHP™ (Disposable High-Performance Handpiece), an important development in a progressive profession moving toward individualized care where patient-to-patient cross contamination is a concern.

C. Mac Waldorf, M.B.A., a founding principal of the Apjohn Group and CEO of Azenic cited the high quality of human capital and the lower cost of living as reasons for doing business in Michigan, as well as the access to funding sources through state and local investors. “The quality of local product manufacturers and professional service providers is a tremendous help to start-up companies such as Azenic,” he said. (www.azenic.com)

CytoPherx About 84,000 people each year will die from acute kidney failure in the U.S and one Ann Arbor company predicts that it “could save up to 70 percent of them,” according to its CFO, Mark R. Morsfield, M.B.A. The

28

CytoPherx aims to significantly reduce mortality from acute kidney failure with a medical device that significantly reduces the body’s inflammatory response.

The company recently changed its name from Nephrion to CytoPherx to indicate that its device may have applications beyond kidney failure such as treating inflammation during coronary bypass surgery and treating severe sepsis and other inflammation mediated diseases. In all cases, the device will help patients with life-threatening conditions. “It’s been 30 years since there have been meaningful therapeutic advances to these disease states,” said Morsfield.

CytoPherx won a $2 million 21st Century Jobs Fund grant in 2008 from the State of Michigan and has received some investment from the Bioscience Research and Commercialization Center at Western Michigan University, as well as private equity investment and venture capital including North Coast Technology Investors of Ann Arbor and Apjohn Ventures from Kalamazoo. The company’s device is in the pilot phase of clinical trials and subsequently will move to the pivotal phase, the final phase before it can be cleared by the FDA and sold in the U.S. (www.cytopherx.com/)

ENTREPRENEURS

Innovator of the Year Finds Renewable Resources to Replace Petroleum-Based Products “governments covet this liquid gold and we’ve become addicted to it.”

The chief barrier to replacing

petroleum with bio-based products is cost and the petroleum paradigm.

“Renewable technologies are mature enough to match the performance requirements of many existing oil-based thermosets and thermoplastics,” Nanos said, “but it takes time to build the bio-based infrastructure to compete This “grow plug” is 95% Canadian peat moss bound with 5% of a bio-based and biodegradable adhesive. Growers like the plug because it holds the peat and the root system intact during replantings, manipulations, and shipping, reducing mortality and improving growth.

John Nanos is on a mission to develop other similar environmentally friendly technologies.

During its annual Expo & Conference, MichBio presents one

economically and to break down oil barriers.”

Nanosystems’ biobased chemistries

are safe for the environment because they are created from

individual with the Innovator of the Year Award, recogniz-

renewable resources. The company is replacing polyurethane

ing his or her significant contribution to the advancement of

in products as diverse as surfboards, agricultural binders used

knowledge and understanding of biological processes through

to hold roots of plants together, packaging materials used in

a novel and innovative technology, process, or product. The

shipping, and rigid foam used as structural support for electri-

2009 recipient, John Nanos, fits that profile well.

cal transmission poles. “I got lucky in chosing niches that were receptive to biotechnologies. I found

Nanos developed a novel bio-based technology and polymer as soil additives and replacements for petroleum-based plastics, foams and other materials.

captive audiences that craved greener materials.”

In 2008, Nanos

formed a joint venRaised in Dearborn, Mich., Nanos earned his BA in chemis-

ture, Inos Technolo-

try from Kalamazoo College and went on to earn a Ph.D. at the

gies, with a Japanese

University of Michigan within their MacroMolecular Science and

based global leader

Engineering program. While working for a mid-Michigan medi-

in polyurethane

cal start-up company, Nanos taught organic chemistry at the

chemistries called

UofM before moving back to Ann Arbor in 2003. In 2005, Nanos’

Inoac. Inoac is a

Nanosystems was born.

John Nanos recently formed a joint partnership with Japanese company, Inos Technologies, which shares his passion for finding bio-based technologies that can do the privately held comsame jobs of petroleum-based products, but be kinder to pany that shares Nanos’ the environment.

passion to respect the

entrepreneurial bug pushed him to form his own company and Nanosystems’ core business is polyurethane foams and

cellular plastics for medical and specialized industrial ap-

power of petroleum but to search for and nurture bio-technolo-

plications, but it is gradually replacing them with bio-based

gies that leave a softer footprint for future generations. With labs

products, which now account for about 15 percent of the

in Ann Arbor, Inos also will be the North American R&D center for

company’s approximately $3.5 million gross revenue. Nanos

Inoac products.

developed a novel bio-based technology and polymer as soil additives and replacements for petroleum-based plastics,

Nanosystems’ biobased chemistries are safe for the environment because they are created from renewable resources.

foams and other materials.

Polyurethanes have been widely used since the 1950’s and

today they pervade every aspect of our society from deck coatings, to padding for beds, furniture and cars, to protection of shipped goods, to implantable devices. Until early 2000, all

polyurethane and plastic products ultimately originated from

SPARK, and the U of M, we’re trying to build Michigan into a

crude petroleum oil. “We’re slaves to petroleum,” Nanos said,

biotech leader.”

29 31

“Along with the strong support of entities such as MichBio,

BioMatters | Spring 2010

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31

BioMatters | Spring 2010

P rofil e

Neogen Plots Course for Continued Success By ?? in Food, Animal Safety Industry

Neogen has made Fortune’s list of “40 Stocks to Retire On” and Forbes’ “200 Best Small Companies in America,” among other accolades, with chairman and CEO, Jim Herbert, at the helm.

One-Stop Shopping

Reports of contaminated pet food from China shocked

readers in recent years, but the threat appears not to be

confined to animals. In April 2007, the New Straits Times

and animal safety products. “This is...not a one-product

Press in Malaysia ran a story asserting that some farmers in

company. It’s a solutions company,” he says. “We develop

China were injecting an industrial dye into eggs to make

diagnostic products to be able to identify where there are

the yolks look fresher and that fishermen used malachite

problems relating to food and animal safety and then we

green, a suspected carcinogen, to improve the appear-

have intervention products that are able to help intervene

ance of some freshwater fish.

to help solve those problems.” The company offers over

“Over half of the seafood that’s consumed in the

200 diagnostic products that identify contaminants ranging

United States comes from China,” says Jim Herbert,

from yeast and molds to E. coli, salmonella, Listeria, and

chairman and CEO of Lansing-based Neogen Corp. “U.S.

Campylobacter.

purchasers of seafood and Chinese officials are very

concerned that the products purchased from China are

the time or the dollars to pull samples and send them

going to be safe for the people in the U.S. to eat.”

out to some independent lab and get the results three to

Herbert describes Neogen as a one-stop shop for food

“Our concept was the food industry couldn’t afford

ten days later — they needed to know on site before they [determined] whether it could be used,” Herbert says. “We

Herbert describes Neogen as a one-stop shop for food and animal safety products.

“This is...not a one-product company. It’s a solutions company.”

developed tests that could be used by someone who was not a trained technician and were simple and easy to use.”

Neogen has been a perennial bright spot in the other-

wise lackluster Michigan economy. Its total revenues have increased from $72.4 million in 2006 to $118.7 in 2009,

Neogen, which develops and markets a wide range

and net income has grown from $7 million to $13.9 mil-

of diagnostic tests for food borne bacteria, food allergens,

lion in the same period. Its investor presentation boasts

and drug residues as well as veterinary products, is

of year-on-year revenue increases for 71 of the past 76

mounting a food safety initiative in China, and Herbert

quarters, and 67 consecutive quarters of profitability.

sees strong demand from exporters and importers alike.

“We’ll introduce a brand new product to China in the

Select Market tier, which has the highest initial listing

spring. It’ll be used to make certain that they don’t have

standards of any exchange in the world. In 2009, it was

a residue contamination, and that same test will be used

included in Fortune magazine’s “40 Stocks to Retire On”

by receivers on this end to make certain that somebody

and was named as one of Forbes magazine’s “200 Best

did test it and it is, in fact, safe,” he says.

Small Companies in America.”

BioMatters | Spring 2010

32

Neogen was named in 2006 to the NASDAQ Global

Four-point Growth Strategy

Life Sciences Experience

Herbert attributes Neogen’s success to its four-point

growth strategy, which includes growing sales from existing

In Your Corner.

products, introducing new products (“We have 55 people in our R&D organization developing new products.”); expansion to international markets (“Over the last three years we’ve grown our revenues from sources outside the U.S. from 27 percent to 42 percent.”); and acquisitions

■ Intellectual property

and strategic alliances (“We’ve done about 16 acquisitions

■ FDA regulatory and enforcement issues

over the last nine years.”).

■ Pharmaceutical patent, trademark and trade dress litigation

Neogen has changed dramatically since Herbert

started the company in 1982 with a secretary and a couple of used desks. It now employs 550 people in

■ Private equity and venture capital

the U.S., Mexico, and Scotland. But Herbert’s guiding philosophy has not changed: adhere to the mission of

■ Day-to-day business advice

being a dominant player in the food and animal safety

■ Manufacturing and supply-chain management

industry, hire good people, and eschew dramatic growth spurts in favor of steady expansion.

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BioMatters | Spring 2010

P ublic P olicy

Michigan House and Senate Appoint Legislative Groups to Focus on the

Bioscience Industry Michigan, like many other states, is competing for the attention of the global biosciences industry in an attempt to diversify and grow a knowledge-based economy. The state has a vibrant biosciences industry with a long history rooted in the pharmaceutical and medical device sectors.

By Tom Beaman According to MichBio President and CEO Stephen Rapundalo, Michigan’s biosciences industry accounts for about 100,000 direct and indirect employees, $2.5 billion in payroll, $500 million in tax revenues, $9.5 billion of the state’s gross domestic product, and it is the largest high tech sector in Michigan.

Out of sight, out of mind Despite such a significant economic impact, Michigan’s biosciences industry has largely been out of sight, out of mind.

“Visibility of the state’s life sciences industry has diminished from a few years ago when the state had a very identifiable Life Sciences Corridor Fund to directly support the

BioMatters | Spring 2010

The Michigan House Subcommittee on Biosciences is chaired by Rep. Ed Clemente, who says he wants to make Michigan as “friendly an environment as possible” for biosciences growth.

industry,” he says. “Legislators in Lansing simply weren’t aware of the positive and considerable contribution made by the state’s biosciences industry once the Fund

34

was rolled into a broader-based technology support program.”

When Rapundalo talks about the bioscience industry with legislative leaders and Governor Jennifer Granholm, he stresses the need for commitment, visibility, and consistency. “First, if you want to reap the potential benefits, one typically starts by laying out a defined game plan and executing on it. Next, if you’re going to be in it, you’ve got to make the industry’s assets, capabilities and opportunities visible to the outside world. And last, we must keep these programs in place over the long term and insure that terms and conditions, features and resources are offered in a consistent manner. We simply must keep

the biosciences industry and its resources visible, accessible, reliable and relevant.”

Rapundalo says states that are successfully growing their bioscience industries have very close relationships with their policymakers, primarily in the form of either legislative caucuses or committees. “Nothing like that existed here in Michigan prior to 2007. The minimal awareness of the biosciences sector’s impact despite its size necessitated a new approach to enhance focus and support for its long-term growth ,” he says.

The Caucus functions to promote, educate, discuss, and formulate potential policy between elected officials, the industry and public.

Biosciences Legislative Caucus gets the ball rolling Rapundalo decided that one way to accomplish MichBio’s mission of driving bioscience growth in the state would be to convene a group of legislators who supported the industry, and were interested to learn more about it as well as finding ways to strengthen it. As a result the Michigan Biosciences Legislative Caucus was created in late 2007 with Sen. Randy Richardville (R-Monroe) and Rep. Rebekah Warren

The Michigan House Subcommittee

on

Biosciences

mechanism by which legislative initiatives targeting the industry could be developed. He and former Congressman and long-time State Senator Joe Schwarz, M.D., approached Senate Majority Leader Michael Bishop in the fall of 2008 about forming a legislative subcommittee to address economic development in the biosciences. In April 2009 Richardville received approval from Bishop to create a

has

held three hearings to date receiving testimony from a range of industry stakeholders.

(D-Ann Arbor) as co-chairs. The Caucus functions to promote, educate, discuss, and formulate potential policy between elected officials, the industry and public. The group now lists over 50 legislators as “members”.

“As we started to get the caucus together, we realized this is just a phenomenal opportunity to develop an industry that has good paying, knowledge-based jobs that will help keep our young people here,” says Warren.

Richardville adds, “We met every few months and talked about legislation, appropriations, what kind of money was necessary, what kind of economic development was going on. Some of us have independently looked at other [bioscience] incubator models around the world, including Israel.”

Complete Policymaking Infrastructure As support and awareness of the Caucus grew, Rapundalo and others recognized the even more important need to have a

“...this is just a phenomenal opportunity to develop an industry that has good paying, knowledge-based jobs that will help keep our young people here.”

Task Force on Biotechnology as part of the Economic Development and Regulatory Reform Committee, which he chairs. Soon after that, Rep. Ed Clemente (D-Lincoln Park) was named to chair a House Subcommittee on Biosciences as part of his New Economy and Quality of Life Committee. As a result, Michigan became the only state whose bioscience industry is officially represented in both chambers of its legislature.

Clemente’s subcommittee has now conducted hearings in Ann Arbor, Rochester Hills, and Grand Rapids. It has received testimony from a range of stakeholders including Oakland County Executive L. Brooks Patterson on

Biotechnology Caucuses or Committees

MN MA

MI PA

IA CA

CO

IL KS

VA

MO

MD

AZ

States with a Dedicated Biotechnology Caucus (11)

FL

States with House Legislative Biotech/Bioscience Commitees (3) States with both House and Senate Legislative Bioscience Committees and Caucus (1)

35

BioMatters | Spring 2010

P ublic P olicy

behalf of the Medical Main Street initiative, Jan Garfinkle, founder and managing director of venture capital firm, Arboretum Ventures, David Zimmermann, chief executive officer at Kalesyn, a Kalamazoo start-up and contract research firm, and Steve Treizenberg, Ph.D., director of the Van Andel Education Institute in Grand Rapids. Richardville’s Senate Task Force will begin its fact-finding in the spring of 2010.

“I’m leaving it to the experts to say whether we need to be in medical devices, or some other cluster, or do a research corridor,” says Clemente. “I just want to make sure that we make it as friendly an environment as possible [for bioscience company growth] so that these things can happen.”

The first task: Connect the dots To date, no legislation has emerged from either the House Subcommittee or the Senate Task Force, but when such measures

eventually see the light of day, they will come face-to-face with the state’s fiscal challenges, a situation faced by many other states. Tax credits, incentives, or modifications to the Michigan Business Tax may be enacted, but Clemente and Warren favor, at least initially, taking advantage of existing resources and improving access to them.

“The question for us is not whether new legislation is needed, but can we identify some of the pieces that are already there? It’s connecting the dots,” says Warren.

Clemente sees value in maintaining a strong Michigan Economic Development Corporation, which has done an excellent job of providing resources to the 15 SmartZones and Business Accelerators, many of which have wet-lab incubators associated with them.

“Most of this stuff doesn’t come through the legislature, a lot of it comes through the MEDC,” he says. “What you do is make sure the MEDC is well funded so that they can sup-

port these kinds of industry sectors. We give them the tools.”

Rapundalo is pleased with the response MichBio has received in Lansing thus far.

He admits the process of re-awakening state government’s appreciation of the bioscience industry is in its early stages, but he’s confident that it will receive more of the support it needs, especially considering the enormous potential the sector holds for the state’s economic diversification and growth.

“The bioscience segment has an unlimited capacity for growth,” he says. “It’s as limitless as innovation can be. It not only underpins our healthcare system but our personal health and lives too. That kind of makes it special. It’s a very meaningful industry and very globally competitive. Michigan has the opportunity to regain its leadership position, but we’re going to have to make a commitment to growing the sector, focus on outcomes, and execute for success.”

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36

public policy

Clinical Trials Tax Credit Could Benefit Michigan Labs

The issue of un-reimbursed costs for participants of clinical

trials has caught the attention of Michigan State Representative Gail Haines (R-Waterford). Haines is currently drafting a bill that would allow any Michigan resident who participates in a clinical trial to claim a credit on his or her Michigan tax return for costs (including medicines, devices, fuel, and lodging) related to their trial that are not reimbursed by the sponsor or insurance.

“The number one roadblock to delaying drug approval is the clinical trial process. If you can shorten that process by encouraging recruitment…it gives me more leverage to say, “Bring your study to Michigan.”

A tax credit would encourage individuals to participate in clinical trials and enable companies like Michigan’s Quest Research Institute to bring more trials into the state.

Haines’s bill has not been formally introduced, but she

believes it would have multiple

Patrick Cardinali of Westland, Michigan, was diagnosed

with Parkinson’s disease in 1998. After receiving the shocking

benefits. In addition to supporting

news, Cardinali asked his doctor what he would do if he were

the development of Michigan’s

in Cardinali’s position. The doctor suggested that he get into

bioscience sector, Haines says her goal is to encourage the use of

clinical trials to help find a treatment. “You never know, you

Representative Gail Haines

might find a drug that will help you,” he offered.

clinical trials to develop treat-

ments and cures. “It shouldn’t cost people to advance medical research,” she says.

Haines is currently drafting a bill that would allow any Michigan resident who participates in a clinical trial to claim a credit on his or her Michigan tax return for costs (including medicines, devices, fuel, and lodging) related to their trial that are not reimbursed by the sponsor or insurance.

“If at least a portion of the cost could be offset, I truly

believe it would enable more individuals and institutions to have interest in participating in clinical trials,” says William Baer, M.D., Pharm. D., executive director and chief medical officer of ClinXus, a community-based research alliance in Grand Rapids.

“We always want to see legislation that encourages

patients…to participate in trials,” says Niles. “The number one roadblock to delaying drug approval is the clinical trial

process. If you can shorten that process by encouraging

Cardinali has been involved in several trials over the years

with different medications and different outcomes. “A big

recruitment…it gives me more leverage to say, “Bring your

benefit was that it was free of charge while you were on the

study to Michigan.”

study, so for a lot of people who didn’t have medication coverage, that was a tremendous savings for them,” he says.

While drug companies normally pay for the costs of clinical

trials, patients are typically responsible for the costs of “concomitant” medications. Many Parkinson’s studies, for example, require that patients also be taking Sinemet, which typically isn’t covered by the sponsor, according to Dolly Niles, president of Quest Research Institute in Bingham Farms, Mich. Niles says such out-of-pocket costs can range from $5 – $8 per week for a rheumatoid arthritis prescription to much more for device studies. “Insurance would pay for that, but how many people are insured today?” she asks. “And everyone still pays the deductible.”

39 37

BioMatters || Spring Spring 2010 2010 BioMatters

e conomic d e v e lopm e nt

The Five Fingers of

Michigan’s “Upper Hand” Advantage

The Right Place Medical Main Street Southwest Michigan First

Ann Arbor SPARK

TechTown

Their names are crafted to capture the imagination with words like First, Right Place, Main Street, SPARK and TechTown. Michigan’s five leading regional economic development and business accelerator organizations each promote their parcel of the state’s geography with gusto.

They know they’ve got what it takes to attract bioscience companies seeking to set up operations or relocate: talent, financial incentives, connections, funding sources and space. Yet each has created its own twist on the story and niche to promote.

“We operate much more like a life science consulting firm,” says Kitchens, citing the availability of Southwest Michigan First’s affiliated angel and venture funds.

Kalamazoo region makes the “First” impression “Southwest Michigan First is one of eight places in the world where you can take a drug from discovery to your pharmacist all within the same geographic area,” touts Ron Kitchens, CEO of Southwest Michigan First, the

BioMatters | Spring 2010

economic development catalyst for Michigan’s Kalamazoo region.

Indeed, the area is home to a host of heavy hitters like Stryker Corporation, Pfizer Animal Health, Perrigo, MPI Research and Borgess Medical Center among others, plus numerous

38

up and comers such as Kalexsyn, Monteris, Metabolic Solutions Development and Vestaron.

“We operate much more like a life science consulting firm,” says Kitchens, citing the availability of Southwest Michigan First’s affiliated angel and venture funds, and its large, modern incubator and wet lab facility.

He also highlights the area’s above average bioscience workforce, a draw that is vital to bioscience companies; its lower cost of living (especially compared to the coastal U.S.); Western Michigan University’s prolific life science labs and programs; land to spare and its strategic location between Detroit and Chicago.

Photo courtesy of The Right Place

Economic D e v e lopm e nt

Kalamazoo Makes Sense for Seneca Medical

The key to successful distribution, says David Myers, sales and marketing vice

president of sales and marketing VP for Tiffin, Ohio-based Seneca Medical, is “a local relationship...with high levels of service.”

For the provider of medical surgical supplies and equipment, it’s all about out-

servicing competitors, and that means personal relationships, “not shipping from five states away.”

“When you drive around Kalamazoo, you see the investment; you can’t help but feel excited.”

Grand Rapids has made a huge investment in building and branding its Medical Mile, an area of bustling bioscience activity.

Infrastructure...and then some...the appeal of Grand Rapids region

The growing company already had distribution centers servicing hospitals, surgery

centers, physicians’ offices, and long-term care facilities in Tennessee, Indiana, Kentucky, Ohio and West Virginia. So when it sought to improve and expand its service base for current customers in Michigan, Northern Indiana and Illinois, Kalamazoo

Fifty miles to the north along the West Michigan corridor is Grand Rapids, another hub where more than $1 billion has been poured into life science development in the past 14 years.

“We have built an infrastructure around biosciences that is very robust,” says Birgit Klohs, CEO of The Right Place, the area’s economic development driver.

was a natural choice. In addition, Kalamazoo-based Bronson Healthcare Group is a major new customer of Seneca Medical, making the area even more attractive for a distribution center.

Myers points out that the guidance of economic developer, Southwest Michigan

First, was invaluable in the process.“They really helped us understand the business advantages of moving into that part of the state: economic viability, great workforce, creative business development areas, distribution range,” said Myers. “When you drive around Kalamazoo, you see the investment; you can’t help but feel excited.”

Seneca’s Kalamazoo distribution center in the Midlink Business Park in Kalamazoo

is a former GM body-stamping plant that has been designated a non-taxable Renais-

...Grand Rapids, another hub where more than $1 billion has been poured into life science development in the past 14 years.

sance Zone. Seneca’s new facility will be located on 10.6 acres in the park and will have 80,000 square feet of space, with the expansion capacity of up to 240,000 square feet. The center started with 25 employees and should have more than 50 as business grows.

“This really is the way it’s supposed to work,” said Ron Kitchens, CEO of Southwest

Michigan First. “We encourage our local community partners to share with us their needs in return for our commitment to work with them on strategically addressing those needs. Bronson Healthcare Group listened, brought us their requirement for a high quality supplier in the region and worked closely with Southwest Michigan First to identify Seneca Medical. This is a win-win for everyone.”

Photo courtesy of Midlink Business Park

Consider the so-called Medical Mile, a burgeoning stretch of real estate that started with the 1996 founding of the Van Andel Institute, now an internationally recognized center for molecular cancer research. The microcosm of research and patient care now includes Spectrum Health’s Butterworth Hospital, Grand Valley State University’s Cook-DeVos Center for Health Sciences, Michigan State University’s Secchia Center Medical School, and Grand Rapids Community College’s Calkins Science Center, among other facilities, with even more under construction or planned.

These community assets helped lure Sequenom, a provider of genetic analysis solutions, to acquire the Grand Rapids-based

With the help of Southwest Michigan First, Ohio-based Seneca Medical is locating a new distribution center in Kalamazoo’s Midlink Business Park to improve and expand its service base in Michigan, Northern Indiana and Illinois.

39

BioMatters | Spring 2010

Photo courtesy of Crittenton Hospital

e conomic D e v e lopm e nt

Medical staff review a sonogram at Crittenton Hospital, a member of Oakland County’s Medical Main Street alliance of hospitals, universities, device and pharma companies aimed at branding the area as a center of excellence.

Center for Molecular Medicine in 2008 and establish a presence in the area along with a promise of employment growth over time.

A competitive package of incentives, introductions to researchers and partners, incubator space and financing sources is key to recruiting companies. They “are making a decision that they can only make once,” says Klohs. “We are trying to position our community as the ‘Right’ community for a company.”

Oakland County’s address is “Main Street” Every town has a nucleus called “Main Street,” but Oakland County has taken the concept to a new level. The affluent Southeast Michigan county has come up with Medical Main Street, a unique alliance of world-class hospitals, universities, medical device and pharmaceutical companies that are leveraging their resources to establish the area as a center of innovation and influence.

Oakland County is already home to numerous bioscience companies including big names like Somanetics, Lumigen, Oxford Biomedical Research and Rockwell Medical Technologies.

And they’ve got the statistics (7th wealthiest U.S. county, twice the Ph.D.’s, Masters’ Degrees and research professionals than the national

BioMatters | Spring 2010

Michigan is not always at the top of the list for some companies, but pointing out costs comparisons...and adding incentives...make a big difference to the decision makers.

average...), the story and the practiced technique to build their life science base even further.

According to Irene Spanos, senior business development representative for Oakland County Planning & Economic Development, Medical Main Street’s board is made up of CEOs from all of the region’s major hospitals along with some of the top bio companies. When a prospective client company evaluates Medical Main Street, “that always opens their eyes.”

Spanos works with life sciences companies that have space requirements of all shapes and sizes. “Often times it’s office space with a little bit of warehouse,” she says. “Some users look for wet laboratory space. Some partner with a research university and use their equipment and have the office space in their building. Some will have the R & D and production done internally.

Sometimes it’s an existing company that has laboratory equipment.”

40

Molecular Innovations, a provider of reagents to scientific researchers, was a small warehouse operation that began in President Duane Day’s garage. Spanos explains: “When they were looking to expand, we helped them identify the site (a 12,600 square foot building in Novi) and arrange financing for the building. Several people there were familiar with Medical Main Street and wanted to be part of that initiative.”

Michigan is not always at the top of the list for some companies, but pointing out costs comparisons between Michigan and the coasts and adding incentives, like Oakland County’s mega tax credit, make a big difference to the decision makers.

“We just have to increase our venture capital,” Spanos notes. And that is moving in the right direction (see story pg. 9)

Ann Arbor is all about the SPARK The presence of the University of Michigan, with its access to leading researchers, state-of-the-art laboratories, world-class hospital system, and many innovative programs to bring technologies to market, is a magnet-like draw to the Ann Arbor area.

According to Elizabeth Parkinson, marketing and communications VP for Ann Arbor SPARK, the region’s official cheer leader, “The common theme [of companies seeking an Ann Arbor location] is the available highly skilled workforce.” In addition, she points out the region’s ample housing and quality schools along with “a strong infrastructure, a major international airport, good IT, available power, and competitive incentive packages.”

“The common theme...is the available highly skilled workforce.”

Ann Arbor SPARK caters to the needs of entrepreneurs with over 200 networking and educational events per year, an active career services program with a database of more than 5,000 job seekers from tech-

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Photo courtesy of TechTown

nicians to CEOs, myriad loan programs, and two business incubators with coaching and administrative services available.

Last October, SPARK, with a coalition of others including Wayne County, opened a 57,000+ square foot high-tech facility in Plymouth, Mich., that boasts wet labs, conference and office space, a cafeteria and fitness center along with other amenities.

Currently 15 start-up companies occupy space in the building, anchored by Esperion Therapeutics and founded by President and CEO, Roger Newton, Ph.D. Previously part of Pfizer, which sold the company in 2008 to Newton and his investors, Esperion focuses on the discovery and development of compounds to treat cardiovascular and metabolic disease.

“It was the resources that kept him here,” says Parkinson. “It was his ability to attract and recruit high-level workers. The state was able to offer tax incentives, [and] we were able to acquire the facility that was owned by Pfizer.”

Shrader Labs, a mass spectrometry laboratory, is one of over 160 small businesses housed at Detroit’s TechTown.

TechTown is Detroit’s entrepreneurial headquarters “Life science companies require many years’ growth before they have significant revenue,” says Randal Charlton, executive director of Detroit’s TechTown. “I think cost control is key.”

In fact, it’s what convinced Charlton to move Asterand, a global supplier of human

Photo courtesy of Ann Arbor SPARK

e conomic D e v e lopm e nt

Ann Arbor SPARK, in concert with Wayne County and others, opened the high-tech Michigan Life Science Innovation Center in Plymouth, Mich., last October to attract and support entrepreneurial companies in the region.

tissue and human tissue-based research services, to Detroit from England in 2000.

Charlton founded and is the former president and CEO of Asterand, which anchors the TechTown business incubator that also houses 160 other companies in a variety of business sectors.

TechTown makes sure its space is affordable, with competitive rates and the option of short-term leases. Thanks to its proximity to universities and hospitals, bioscience companies in the area also have direct access to resources for partnering and collaboration. (For example, Asterand worked with Wayne State University to develop and build its tailor-made laboratories.) Wayne State’s office of Technology Commercializa-

“Life science companies require many years’ growth before they have significant revenue. I think cost control is key.” tion is located within TechTown, an added benefit to the entrepreneurs that reside in the center.

“We are trying to offer a concierge service,” Charlton says of TechTown’s approach, which includes entrepreneurial programs like FastTrac and SmartStart, networking, mentoring and small business loans as well as access to investors in the Midwest.

David Shenkenberg contributed to this story.

A competitive package of incentives, introductions to researchers and partners, incubator space and financing sources is key to recruiting companies.

They “are making a decision that they can only make once.”

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opinion

What’s So Good About Doing Bio-Business in Michigan?

Let These Industry Leaders Tell You…

“This is a great time for bioscience companies in Michigan as the state works to revive its economy with more technology-based jobs. The human resources are also available as the state’s outstanding colleges and universities graduate top students in the biosciences.

Jim Herbert, CEO Neogen Corporation “… a wealth of talent with an unbeatable work ethic. Michigan is a great place to live and grow a biotechnology company.”

Bill Brinkerhoff COO, Cerenis Therapeutics “… easy access to world-class research and talent coupled with readily available transportation makes Michigan a distinctive place to run a bioscience company.”

Karen Studer-Rabeler VP, Business Development, Coy Laboratory Products “… the presence of several biotechnology incubators and state funding provide an ideal environment for starting a biotechnology business.”

Dean Shinabarger CEO, Micromyx “… bright ideas, superb collaborators, talented and experienced employees of all types, solid infrastructure, capital -- and it is a fabulous place to live!”

Jen Baird Former President & CEO, Accuri Cytometers “… a wide variety of resources to support early stage development including funding, mentors, trial sites, a nurturing culture and much more.”

Stuart Main CEO, HealthCure LLC “One advantage of a Michigan-based company is the cost of running a business. The few competitors we have simply can’t compete with us based on overhead cost. Simply put, we can do the same work for less and still have a higher profit margin. This benefits the client and eventually, the patient.”

Daniel Ross, President & CEO TransPharm Preclinical Solutions, LLC “… the brain power and diversity of resources (You have a whole corporation essentially right here in your own backyard!)”

Loretta Cipkus Dubray President and CEO, Global Clinical Connections, LLC “… an excellent location for medical device companies. The state has a large pool of highly trained engineers, a tradition of skilled assembly workers, strong University presence with medical, engineering and business resources to draw from and an underutilized but rich supplier base.”

Mark Sutter CEO, Terumo Cardiovascular Systems “… a phenomenal place to accelerate the development of your life science business because of outstanding talent, agile commercialization infrastructure, and access to venture funding.”

Linda Chamberlain, Ph.D. Executive Director, Center for Entrepreneurship & Innovation Grand Valley State University

BioMatters | Spring 2010

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G uest O pinion

My Opinion

Academic-Industry Partnerships: Reaching Out, Reaching In

By Jim O’Connell and Daryl Weinert Over the past decade, there has been a trend in many U.S. industries towards less in-house research and development. Cutting edge technologies are very unpredictable, both scientifically and commercially. Instead of internally supporting 10 unpredictable technologies, to maintain consistent financial performance, it makes sense for a company to look towards mergers and acquisitions for the “next new thing.”

During this same timeframe many universities have begun to understand the value of commercialization as an important extension of their traditional “basic science” mission.

There are now a large number of programs within Michigan universities and colleges focusing on both learning about and teaching “how to translate technology to industry.”

These programs look to de-risk technologies in an effort to “tee up” licensing deals for companies and create business opportunities for startup companies. For universities to effectively de-risk, they have to understand the risk perspective across many industries.

The only way to accomplish this is through regular interaction and partnering with industry.

At the University of Michigan, two entities have been created to reach out and reach in.

In order to unlock the potential of academic-industry partnerships it is critical that academic institutions develop mechanisms that will support the general ecosystem for industrial interaction on campus. Traditionally ‘corporate relations’ on campus was a one-dimensional effort, focused exclusively on the philanthropic relationship between industry and the university. But here in Michigan that paradigm is rapidly evolving, and the University of Michigan, Michigan State and Wayne State are all moving forward with broadly reaching ‘corporate relations’ offices that can help bioscience companies find talent, explore research partnerships, educate their professional staff, identify technologies, engage with students, and consult with faculty. Industry now needs to develop similar mechanisms to promote mutually beneficial connections. At the University of Michigan, this entity is known as the Business Engagement Center (www.bec.umich.edu).

On the business creation side of the equation, the Michigan Venture Center has been created to serve as a central connection point for venture opportunity creation resulting from of University of Michigan intellectual property. The Venture Center takes technology and faculty with potential to form a startup company, and connects them with both external entrepreneurs and investors. Staffed with startup and industry-experienced business people, they form the bridge between the needs of the business world and the huge technology potential that exists inside the university. A great example was one of the largest, venture capital series “A” finance rounds in the Midwest; Histosonics, a startup company based on a novel treatment for benign prostate hyperplasia, recently received $11 million.

With groups like these specifically focused on enhancing the interaction between academia and industry, we can expect to see an acceleration of new opportunities coming out the doors of all Michigan universities and colleges to support the bioscience industry in the state.

Jim O’Connell is the director of the University of Michigan’s Michigan Venture Center (innovationeconomy.umich.edu/michigan-venture-center/).

Daryl Weinert is the executive director of U-M’s Business Engagement Center (bec.umich.edu/index/).

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BioMatters | Spring 2010

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BioMatters | Spring 2010 3/1/2010 1:02:19 PM

BioMatters M AY 2 0 1 0

Michigan Biosciences 2010 DIRECTORY and RESOURCE GUIDE MichBio is pleased to provide the 2010 Michigan Biosciences Directory and Resource Guide, the most comprehensive listing of the state’s biosciences companies and organizations.

The complete directory, which includes the information here plus profiles, and listings by sector and county is available at www.michbio.org.

Please Note: Information contained in the 2010 Michigan Biosciences Directory and Resource Guide is as current as possible. All attempts were made to validate information submitted by companies and to update existing data in MichBio’s database. If your company or organization is not listed, and you believe it should be, please visit the MichBio website at www.michbio.org and register your company.

Direct questions to MichBio at info@michbio.org or 734.527.9150.

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BioMatters | Spring 2010

Abundant Resources Help Ideas Become

Life-Changing Realities General Resources MichBio is the statewide association committed to building Michigan’s biosciences industry into a growth engine for a revitalized economy. Its members are biosciences companies, academic and research institutions, bioscience service providers, and related organizations. MichBio is dedicated to fostering their collective impact by connecting its members with the essential resources, including goods, services, educational and networking programs, legislative representation, and partners that facilitate success. www.michbio.org (734) 527-9150 BioConnections is a job bank resource for MichBio members matching talented life sciences pro-fessionals with fulfilling positions in the state through an online talent search mechanism. www.michbio.org/BioConnections (734) 527-9150 Great Lakes Entrepreneur’s Quest (GLEQ) helps Michigan entrepreneurs build highgrowth, new economy business ideas into successful ventures by linking them to a statewide network of resources, expert advice, education and capital. Twice a year, GLEQ hosts a statewide business plan competition with cash prizes, media exposure and business development services. www.gleq.org (734) 527-9151

Michigan Economic Development Corporation (MEDC) is the state’s onestop resource for businesses seeking to grow in Michigan. Created through cooperation between state and local governments, the MEDC works with local communities and businesses to retain and expand job opportunities and improve Michigan’s overall business climate. www.michiganadvantage.org (888) 522-0103 Michigan Small Business & Technology Development Center (SBTDC) provides counseling, training, research and advocacy for new ventures, existing small businesses and innovative technology companies. Headquartered at Grand Valley State University, the SBTDC supports 12 regional offices and over 30 satellite offices in the state. www.gvsu.edu/misbtdc (616) 331-7480 New Enterprise Forum links entrepreneurs with management expertise, joint venture partners, business services, capital, and other critical resources. www.newenterpriseforum.org (734) 665-4433 Small Business Association of Michigan helps Michigan small businesses succeed by promoting entrepreneurship, leveraging buying power and engaging in political advocacy. www.sbam.org (800) 362-5461

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centers OF excellence Biosciences Research and Commercialization Center of Western Michigan University is a commercially focused and science driven translational research center that dedicates its pharmaceutical expertise and resources to the commercialization of promising bioscience discoveries and the growth of Michigan’s bio-science business sector. www.brcc.wmich.edu (269) 544-1072 Grand River Aseptic Pharmaceutical Packaging is a fully validated, FDA/cGMP facility associated with the VAI and Grand Valley State University (GVSU) and serves the bio/pharmaceutical industry by offering aseptic fill-finish, lyophilization, client-driven custom packaging services and cold product storage. www.grandriverapp.com (616) 644-0555 Michigan Animal Models Consortium (MAMC) provides services associated with the development, analysis and maintenance of mouse models of human disease. The consortium combines the technological, IP expertise and facility resources at the AAALAC-accredited Van Andel Institute (VAI). The MAMC provides efficient and cost-effective animal modeling services. www.ctaalliance.org/cta-cores/michigananimal-model-consortium (616) 234-5684

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Michigan Antibody Technologies Center (MATC) consists of the Monoclonal Antibody Technology Core at the VAI and the Hybridoma Core at the University of Michigan (U-M). The MATC has extensive capabilities in the generation, characterization, scale-up and purification of mAbs and fragments. www.vai.org/Research/Labs/AntibodyTechnology.aspx (616) 234-5342 Michigan Biological Imaging Center (MBIC) provides comprehensive scientific/ technical imaging expertise including drug safety and efficacy data to pharmaceutical industry clients. homepages.wmich.edu/~eversole (269) 387-5640 Michigan Center for Biological Information (MCBI) provides advanced bioinformatics and computational resources for investigators and in the academic and industrial sectors. This includes access to bioinformatics tools, genomics and proteomics databases, supercomputing resources, bioinformatics training, and bioinformatics consulting. www.ctaalliance.org/MCBI (734) 615-5814 Michigan Center for Bioscience Commercialization (MCBC) is a contract research and development organization located at the BRCC. The MCBC provides scientific, medical and regulatory consultation to aid in the development and commercialization of pharmaceutical, diagnostic and medical device discoveries. www.brcc.wmich.edu (269) 544-1072 Michigan Center for Structural Biology (MCSB) is designed to provide state-of-theart instrumentation and support in the area of macro-molecular structure/function determination for drug discovery. This includes x-ray crystallography, NMR spectroscopy, EPR spectroscopy, single molecular spectroscopy, protein expression and production and

macromolecular structure, synthesis and sequencing. The MCSB is partnered with and utilizes beamline resources at the Argonne National Labs. mcsb.bch.msu.edu (517) 355-0199 Michigan High-Throughput Screening Center (MHTSC) is a contract research facility providing services in assay development and optimization and high throughput screening. Staffed by pharmaceutical industry scientists with drug discovery and HTS experience, the MHTSC offers screening of a 100,000+ compound library for a broad range of therapeutic targets with the client retaining IP rights to compounds identified in the screenings. www.mhtsc.kvcc.edu (269) 353-1582 Michigan Proteome Consortium (MPC) provides proteome mapping (protein interaction maps, membrane protein analysis, posttranslational modifications), high-throughput yeast two-hybrid screening, and proteome informatics services to both academic and industry clients. www.proteomeconsortium.org (734) 763-3130 Wayne State University Applied Genomic Technologies (MCGT) provides oligonucleotide genechip microarrays, custom cDNA microarrays, and other genomic technology services on a fee-basis. State-of-theart equipment and a full suite of molecular genomic tools for processing and analysis means an integrated offering for gene expression profiling and HTS data mining. www.bioinformatics.wayne.edu/MCGT (313) 577-3555

Michigan-Based Funding Sources The 21st Century Jobs Fund represents a bold initiative to diversify Michigan’s economy and stimulate job creation in emerging technology sectors. After being introduced by the Governor in 2005, it re-

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ceived broad, bi-partisan support in the state Legislature. Using tobacco settlement dollars, it has already invested $156 million in over 95 commercialization projects in the life sciences, advanced manufacturing, alternative energy, and homeland security/defense sectors through business plan competitions.

In addition, the 21st Century Jobs Investment Fund was deployed to invest $109 million in venture capital and private equity funds.

To date nearly $75 million has been invested and attracted significant fund management activity to Michigan, providing Michigan entrepreneurs access to more diverse capital. www.michiganadvantage.org/21 Michigan Initiative for Innovation and Entrepreneurship The Michigan Initiative for Innovation & Entrepreneurship (MIIE) builds on Michigan’s universities as economic assets by speeding the commercialization of university research while promoting a culture of entrepreneurial risk-taking. The initiative partners Michigan’s philanthropic resources with university and private business resources to help launch new startup companies, and strengthen ties between small business, industry and academia. www.pcsum.org/miie.html (734) 647-5730 Michigan Pre-Seed Capital Fund supports high-tech start-up companies as they near commercial viability by providing access to early-stage capital to accelerate company development. These funds extend the personal investment of entrepreneurs during the critical stage when they are developing their businesses to the point of readiness for outside investment. Information is available from local SmartZones™ or www.AnnArborUSA.org Venture Michigan Fund is a $95 million venture capital investment program formed under the Michigan Early Stage Venture Investment Act of 2003 to promote Michigan’s economic health by assisting in the creation of jobs, new businesses and new industries

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within the state. The VMF makes investments ONLY in venture firms that invest primarily in Michigan-based early stage companies. www.venturemichigan.com

Grand Angels www.grandangels.org

Federal Funding Opportunities are listed in the SSTI Weekly Funding Supplement offered by the federal government, foundations and other industries. www.ssti.org/Digest/supplement.htm

Great Lakes Entrepreneur’s Quest www.gleq.org

Michigan Bio-focused Venture and Angel Groups Ann Arbor Angels www.annarborangels.org Apjohn Group, LLC www.apjohnventures.com Arbor Partners www.arborpartners.com Arboretum Ventures www.arboretumvc.com Ardesta, LLC www.ardesta.com Beringea www.beringea.com BioStar Ventures www.biostarfund.com Bridge Street Capital www.bridgestreetcapital.com Capital Community Angels www.capitalcommunityangels.org Dow Venture Capital www.dow.com/venture EDF Ventures www.edfvc.com Entrepreneurs and Investors Exchange www.EntrepreneurInvestorExchange.com First Angels www.swmfirst.com/First_Angels.cfm Fletcher Spaght Ventures www.fletcherspaght.com/ventures

Great Lakes Angels www.glangels.org

Hartwick Capital www.hartwickcapital.com Hopen Therapeutics www.hopentherapeutics.com Midwest Venture Partners www.midwestvp.com Michigan Venture Capital Association www.michiganvca.org North Coast Technology Investors www.northcoastvc.com Oracle Capital Partners, LLC www.oracle-capital.com Plymouth Management Company www.plymouthvc.com Renaissance Venture Capital Fund www.renvcf.com Seneca Partners www.senecapartners.com Sigvion Capital www.sigvion.com Southwest Michigan First Life Science Fund www.southwestmichiganfirst.com TGap Ventures www.tgapventures.com Triathlon Medical Ventures www.tmvp.com

Technology Transfer Offices: l Central Michigan University www.orsp.cmich.edu (989) 774-4000 l Eastern Michigan University www.ord.emich.edu (734) 487-3090 l Ferris State University www.ferris.edu (231) 591-5983 l Grand Valley State University www.gvsu.edu/research_dev (616) 331-2281 l Michigan State University http://www.oip.msu.edu/ (517) 355-2186 l Michigan Technical University www.admin.mtu.edu/adv/cs/ (906) 487-2228 l Northern Michigan University webb.nmu.edu/Departments/TOS (906) 227-2190 l Oakland University www2.oakland.edu/research (248) 370-2552 l Saginaw Valley State University http://www.svsu.edu/cbed (989) 964-4047 l University of Michigan www.techtransfer.umich.edu (734) 763-0614 l Van Andel Research Institute www.vai.org (616) 234-5000

Wolverine Venture Fund www.zli.bus.umich.edu/wvf

l Wayne State University www.techtransfer.wayne.edu (313) 577-5541

University Research and Technology Transfer

l Western Michigan University www. www.brcc.wmich.edu (269) 544-1072

Michigan Universities Commercialization Initiative (MUCI) complements and enhances technology transfer functions at Michigan academic and research institutions by supporting commercialization of Intellectual Property. www.muci.org

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University Research Corridor is an alliance between Michigan’s three major research universities to transform, strengthen and diversify the state’s economy. The partners, Michigan State University, the University of Michigan and Wayne State University, spark regional economic development via invention, innovation and technology transfer, by educating a work force prepared for the knowledge economy, and by attracting smart and talented people to Michigan.

(734) 647-1844 ww.urcmich.org

SmartZones and Business Accelerators SmartZonesTM provide distinct geographical locations where technology-based firms, entrepreneurs and researchers locate in close proximity to all of the community assets that assist in their endeavors. SmartZoneTM technology clusters promote resource collaborations between universities, industry, research organizations, government and other community institutions, growing technologybased businesses and jobs. New and emerging businesses in SmartZoneTM technology clusters are primarily focused on commercializing ideas, patents and other opportunities surrounding corporate, university or private research institute R&D efforts. www.michigan.org/smartzones l Ann Arbor/Ypsilanti: Ann Arbor SPARK, University of Michigan, Eastern Michigan University 201 S. Division St., Suite 430 Ann Arbor, MI 48104 (734) 761-9317 www.AnnArborUSA.org Contact: Michael Finney l Automation Alley Lawrence Institute of Technology, Oakland University Automation Alley Technology Center 2675 Bellingham Rd Troy, MI 48083 (248) 457-3200 www.automationalley.com Contact: Tom Anderson

l Battle Creek Aviation & e-Learning Western Michigan University, Kellogg Community College 4950 West Dickman Rd. Battle Creek, MI 49037 (269) 962-7526 www.bcunlimited.org Contact: Karl Dehn

l Kalamazoo: WMU Business Technology & Research Park Western Michigan University 4717 Campus Drive, #100 Kalamazoo, MI 49008 (269) 353-1823 www.kazoosmic.com Contact: Robert DeWit

l Detroit/Woodward Technology Corridor: TechTown Wayne State University 440 Burroughs, Entrepreneurial Suite Detroit, MI 48202 (313) 879-5250 www.techtownwsu.org Contact: Randal Charlton

l Lansing/East Lansing: University Corporate Research Park 2727 Alliance Drive, Ste. C Lansing, MI 48910 (517) 432-1753 ucrp.msu.edu Contact: George Benson

l Grand Rapids: West Michigan Science & Technology Initiative Grand Valley State University, Van Andel Institute 301 Michigan St NE, Suite 536 Grand Rapids, MI 49503 (616) 331-5840 www.wmsti.org Contact: Rich Cook l Houghton/Hancock: Michigan Tech Enterprise Corporation Michigan Technical University Advance Technology Development Complex 101 West Lakeshore Drive Houghton, MI 49931 (906) 487-7000 www.mtecsmart.com Contact: Carlton K. Crothers l Jackson Technology Park Baker College, Jackson Community College, Spring Arbor University One Jackson Square, Suite 1100 Jackson, MI 49201 (517) 788-4455 www.enterprisegroup.org Contact: Scott Fleming

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l Macomb INCubator Oakland University 7205 Sterling Ponds Court Sterling Heights, MI 48312 (586) 463-2542 www4.oakland.edu/macombouinc Contact: David Spenser l Midland: Mt. Pleasant SmartZoneTM Satellite MidMichigan Innovation Center 4520 E. Ashman Rd., Suite M Midland, MI 48642 (989) 839-2333 www.midmichiganinnovationcenter.org Contact: Chris Moultrup l Mt. Pleasant: Center for Applied Research & Technology Central Michigan University 2625 Denison Drive Mt. Pleasant, MI 48858 (989) 774-2424 www.cmurc.com l Muskegon Lakeshore Grand Valley State University 380 W. Western Ave, Suite 202 Muskegon, MI 49440 (231) 724-6702 www.muskegonareafirst.org Contact: Ed Garner

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l Rochester Hills: Oakland University INCubator Oakland University Shotwell-Gustafson Pavilion, Oakland University 2200 N. Squirrel Road Rochester, MI 48309 (248) 648-4800 www.oakland.edu/ouinc Contact: David Spencer l Sault St. Marie Economic Development Corp.

1301 West Easterday Ave. Sault Ste. Marie, MI 49783 (906) 635-9131 www.saultedc.com Contact: Jim Hendricks l Wayne County: Pinnacle Aeropark University of Michigan, Wayne State University, Detroit Metropolitan Airport 600 Randolph Street, Third Floor Detroit, MI 48226 (313) 224-6076 www.waynecounty.com Contact: Dave Tyler

Selected Michigan County Economic Development Organizations Alcona ww.alconacountymi.com Allegan www.allegancounty.org Bay www.baycounty-mi.gov/EACD/EconomicDevelopment.aspx

Calhoun www.calhouncountymi.org

Newaygo www.ncedo.org

Genesee www.thegrcc.org

Oakland www.oakgov.com/peds

Houghton www.houghtoncounty.net

Ontonagon www.ontcoedc.com

Ingham www.ingham.org/DV/developm.htm

Otsego www.otsego.org/econdev.htm

Ionia www.icea-mi.org

Ottawa www.co.ottawa.mi.us

Isabella www.mmdc.org

Saginaw www.saginawfuture.com

Jackson www.co.jackson.mi.us/JCinfo.asp

Sanilac www.sanilaccounty.org

Kalamazoo www.southwestmichiganfirst.com

Schoolcraft www.schoolcraftedc.com

Kent www.rightplace.org

St. Clair www.edascc.com

Leelanau www.leelanaucounty.com/edc.asp

St. Joseph www.sjcedc.com

Lenawee www.lenawee.mi.us

Traverse Bay www.tcchamber.org

Livingston www.livingstonedc.com

Van Buren www.vbco.org/econdev0003.asp

Manistee www.allianceforeconomicsuccess.com

Washtenaw www.AnnArborUSA.org

Marquette www.marquette.org/economic_main.html

Wayne www.waynecounty.com/jed

Macomb www.macombcountymi.gov/MCPED

For a complete list of Michigan economic development organizations, please visit www.ecodevdirectory.com/Michigan.htm

Mason www.masoncountyedc.com

Benzie www.benziecountyedc.com

Midland www.midlandtomorrow.org

Berrien www.berriencounty.org

Monroe www.monroecountyidc.com Muskegon www.muskegonareafirst.org

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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A IgO-SBCio B I E/NI ndustrial CES Ag-Bio/Industrial A.M. Todd Abbott Nutrition AEGIS Environments Agrium Algal Scientific Corp.

Bayer CropScience Bio-lab, Inc. Bio-Nano Power, LLC Biotectix BoroPharm, Inc. Bridge Organics Co. Burdick & Jackson Caltech Industries, Inc. Cerise Nutraceuticals, Inc. Chemtura Dendritech, Inc. Dendritic Nanotechnologies, Inc. Diversified Natural Products Draths Corp.

EcoSynthetix Elan Nutrition Emerald BioAgriculture Corp. / Auxein Corp.

GANTEC, Inc. Gerber Product Company Graminex, LLC H2 EnviroFuel Haviland Enterprises HealthCure, LLC Healthtreat, Inc. Horseshoe Herbals Idea Sphere, Inc. Intermediary Biochemicals, LLC J. Rettenmaier, USA Kalsec, Inc. Kellogg Company Koppert Biological Systems, Inc. KTM Industries Labtech Industries Mayaterials MBI International Mead Johnson Nutrition Microcide, Inc. Nanosystems Neogen Corp.

Next Generation Therapeutics, Inc Nitrate Elimination Company, Inc. Orthopedic Development, Inc. PVS Chemicals, Inc. ReNew Systems SPI Pharma SubTerra LLC Superior Growers Supply The Dow Chemical Company Thorn Smith Laboratories Thumb Oilseed Producers Troy Polymers

1717 Douglas Avenue 901 North Centerville Rd. 2205 Ridgewood Dr. 2405 Vassar Rd. 46701 Commerce Center Dr. 1740 N. Whitehall 1400 East Michigan St. 2625 Denison Dr. 3550 W. Liberty Rd., Ste. 3 39555 Orchard Hill Place, Ste. 600 311 West Washington St. 1953 S. Harvey St. 4520 East Ashman Rd., Ste. C 1670 Barlow St., Ste. A 1400 East Michigan St. 3110 Schuette Dr. 2625 Denison Dr., Ste. B 506 East State St. 2367 Science Parkway, Ste. 2 3900 Collins Rd. 4490 44th St. Southeast 2123 University Park Dr., Ste. 105 4520 East Ashman Rd., Ste. A 445 State St. 95 Midland Rd. PO Box 36129 421 Ann NW 390 Park St., Ste. 110 30777 Northwestern Highway, Ste. 300 1219 Anderson Rd. 3133 Orchard Vista Dr SE 2529 Dustin Rd. 16369 US Highway 131 PO Box 5051 One Kellogg Square, PO Box 3599 2856 South Main St. 3327 Ranger Rd. 7707 Lyndon 661 Airport Blvd., Ste. 1 3900 Collins Rd. 725 E. Main St. 2727 Second Ave. #334 3588 Plymouth Rd., Ste. 326 620 Lesher Place 46701 Commerce Center Dr., Ste. A-6 334 Hecla St. 6565 West Main St. 10900 Harper Ave. 1009 S. Henry St., PO Box 1072 PO Box 226 PO Box 55, 104 Wilcox Rd. 4870 Dawn Ave. 2030 Dow Center 7755 Narrow Gauge Rd. 2145 Leppek Rd. 330 E. Maple, Ste. L

Kalamazoo, 49007 269 343-2603 Sturgis, 49091 269 651-0787 Midland, 48642 800 241-9186 Reese, 48757 989 752-2138 Plymouth, 48170 734 218-5717 Muskegon, 49445 231 719-3000 Adrian, 49221 517 265-6138 Mt. Pleasant, 48858 616 682-0367 Ann Arbor, 48103 734 995-9089 Novi, 48375 888 366-1496 Vicksburg, 49097 616 649-4200 Muskegon, 49442 231 726-3171 Midland, 48642 989 496-3110 Traverse City, 49686 231 933-3300 Adrian, 49221 517 265-6138 Midland, 48642 989 496-2016 Mt. Pleasant, 48858 989 774-6565 Scottville, 49454 231 757-9241 Okemos, 48864 517 349-0669 Lansing, 48910 517 336-4649 Grand Rapids, 49512 616 940-6000 Okemos, 48864 517 882-7370 Midland, 48642 877 816-9300 Fremont, 49413 231 928-2000 Saginaw, 48638 877 472-6469 Grosse Pointe Shores, 48239 910 232-7601 Grand Rapids, 49504 800 456-1134 Birmingham, 48009 248 282-9300 Farmington Hills, 48334 248 855-0033 Niles, 49120 269 684-6888 Grand Rapids, 49546 616 464-5000 Okemos, 48864 N/A Schoolcraft, 49087 877 895-4099 Kalamazoo, 49005 269 349-9711 Battle Creek, 49016 800 962-1413 Ann Arbor, 48103 734 641-3763 Lansing, 48906 517 703-9140 Detroit, 48238 313 862-1737 Ann Arbor, 48108 734 994-7035 Lansing, 48910 517 337-3181 Zeeland, 49464 812 429-5000 Detroit, 48201 888 342-6279 Ann Arbor, 48105 734 274-0020 Lansing, 48912 800 234-5333 Plymouth, 48170 734 527 9139 Lake Linden, 49945 906 296-1000 Kalamazoo, 49009 269 544-4715 Detroit, 48213 313 921-1200 Bay City, 48706 989 892-4552 Grand Haven, 49417 231 935-6900 White Pine, 49971 906 885-5953 East Lansing, 48823 800 227-0027 Midland, 48674 800 258-2436 Beulah, 49617 231 882-4672 Ubly, 48475 989 658-2344 Troy, 48083 248 733-1030

amtodd.com/flash_content.php abbott.com microbeshield.com agrium.com algalscientific.com bayercropscience.com chemtura.com N/A biotectix.com boropharm.com bridgeorganics.com bandj.com caltechind.com cherrylotion.com chemtura.com dendritech.com dnanotech.com dnpworld.com drathsCorp..com ecosynthetix.com elannutrition.com emeraldbio.com gantecinc.com gerber.com/ graminex.com N/A havilandusa.com healthcure.biz healthtreat.com horseshoeherbals.com ideasphereinc.com N/A jrsusa.com kalsec.com kelloggcompany.com koppert.com ktmindustries.com N/A mayaterials.com mbi.org meadjohnson.com microcide.com N/A neogen.com nextgenerationtherapeutics.com nitrate.com N/A pvschemicals.com renewsystems.com spipharma.com subterrallc.com superiorgrowers.com dowventurecapital.com thornsmithlabs.com thumboilseed.com troypolymers.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B I O S C I E N C E S continued Ag-Bio/Industrial continued Uckele Health and Nutrition Van Beek Nutrition Vertellus Health and Specialty Products, LLC Vestaron Corp.

Wacker Chemical Corp.

Working Bugs, LLC XG Sciences, Inc.

P.O. Box 160 3537 West YZ Ave. 215 North Centennial St. 4717 Campus Dr., Ste. 1200 3301 Sutton Rd. 16647 Chandler Rd. 5020 Northwind Dr., Ste. 212

Blissfield, 49228 Schoolcraft, 49087 Zeeland, 49464 Kalamazoo, 49008 Adrian, 49221 East Lansing, 48823 East Lansing, 48823

800 248-0330 269 679-5441 800 223-0453 269 372-8745 517 264-8793 517 203-4744 517 203-1110

uckele.com vanbeeknutrition.com vertellus.com vestaron.com wacker.com workingbugs.com xgsciences.com

Ann Arbor, 48105 Rockford, 49341 Ann Arbor, 48105 Ann Arbor, 48104 Ann Arbor, 48103 Ann Arbor, 48103 Cadillac, 49601 Ann Arbor, 48105 Ann Arbor, 48108 Ann Arbor, 48104 Walled Lake, 48390 Galesburg, 49053 Saline, 48176 Ann Arbor, 48108 Dexter, 48130 Troy, 48098 Ypsilanti, 48197 Ypsilanti, 48198 Ann Arbor, 48104 Ann Arbor, 48104 Ann Arbor, 48108 St. Joseph, 49085 Ann Arbor, 48108 Ann Arbor, 48108 Ann Arbor, 48104 Ann Arbor, 48104 Ann Arbor, 48103 Ann Arbor, 48108 Langhorne, PA 19047 Livonia, 48150 Southfield, 48075 Ann Arbor, 48103 Ann Arbor, 48105 Okemos, 48864 Novi, 48376 Novi, 48375 Manchester, 48158 Okemos, 48864 Ann Arbor, 48105 Ann Arbor, 48104 Ann Arbor, 48104 Ann Arbor, 48108 Lansing, 48909 Ann Arbor, 48105 Traverse City, 49684 Grand Rapids, 49546 West Bloomfield, 48324

734 302-4600 616 292-5018 888 284-4080 734 604-1966 734 913-1098 734 255-1038 231 779-0224 734 827-1000 734 922-4066 734 929-3909 734 730-4692 269 665-4420 734 668-0005 800 292-3763 734 426-4995 248 952-1968 734 434-7734 734 604-8214 734 222-9080 N/A 734 769-7249 888 592-3124 734 929-9475 877 436-6628 734 623-0000 734 332-0612 734 929-5392 734 205-1231 N/A 734 779-8800 N/A 734 665-5400 734 487-1251 517 203-0194 877 563-8633 866 533-7172 734 678-7342 N/A 734 665-0701 734 476-8502 866 288-9758 734 913-3000 N/A 800 332-4463 231 946-5868 616 234-5586 248 858-2606

altarum.org arivium.com avicenna-medical.com N/A biomedware.com BioPharmaDataServices.com blueware.net cielomedsolutions.com coherix.com compendiabio.com conceptsinsoftware.com contentedhearts.com critech.com cybernetmedical.com dissdata.com dataspeaks.com ddots.com dermanaut.com dnasoftware.com gehealthcare.com/usen/hit/index.html genecodes.com genego.com genetics2.com genomatix-software.com healthmedia.com informmed.com INDS-Inc.com inviasolutions.com jnj.com mckesson.com medelephant.com medimage.com mersllc.com N/A neumedicine.com nutriinfo.com polyergic.com N/A N/A N/A therapycharts.com thomsonreuters.com txisllc.com unival-med.com versustech.com xbtransmed.com yoursurgery.com

INFORMATION TECHNOLOGY Altarum Institute 3520 Green Ct., Ste. 300, PO Box 134001 Arivium, Inc. 354 Glen Arbor Dr. NE Avicenna Medical Systems, Inc. 3090 Dhu Varren Ct. Better Rehab, LLC 1170 Morehead Ct. BioMedware Inc. 3526 W. Liberty Rd., Ste. 100 BioPharma Data Services 1461 Scio Ridge Ct. BlueWare, Inc. 3060 West 13th St. Cielo MedSolutions 3520 Green Court, Ste. 150 Coherix, Inc. 3980 Ranchero Dr. Compendia Bioscience 110 Miller Ave., Fl. 2 Concepts in Software 455 Woodland Hills Dr. Contented Hearts, Inc. 11490 East G Ave. Critech Research, Inc. 1705 Woodland Dr. East, Ste. 100 Cybernet Medical 727 Airport Blvd.

Data Integrated Scientific Systems 8031 Main St., Ste. 301 DataSpeaks, Inc. 2971 Vineyards Dr. DDots, Inc. 4571 Ellsworth Rd. Dermanaut 702 Dwight St. DNA Software, Inc. 334 East Washington St. GE Medical Systems Information Technology 3300 Washtenaw Ave., Ste. 225 Gene Codes 775 Technology Dr., Ste. 100 GeneGo, Inc. 500 Renaissance Dr., Ste. 106 Genetics Squared, Inc. 401 West Morgan Rd. Genomatix Software, Inc. 3025 Boardwalk, Ste. 160 HealthMedia, Inc. 130 South First St. InformMed 1710 Hermitage Rd. Integrated Nonclinical Development Solutions, Inc. (INDS) 3005 Miller Ave. INVIA Medical Imaging Solutions 3025 Boardwalk St., Ste. 200 Johnson & Johnson P.O. Box 726 McKesson Pharmacy Systems 30881 Schoolcraft MedElephant, Inc. 21700 Northwestern Hwy, Ste. 110 MedImage, Inc. 6276 Jackson Road, Suite G MERS, LLC 799 Skynob Dr. MetagenX, LLC 4316 Aztec Way NeuMedicine PO Box 756 Nutriinfo.com 41850 W. 11 Mile Rd., Suite 106 POLY Bioinformatics 12191 E. Austin Rd. Qtox, LLC 1828 Yosemite Dr. ScreenTrack 1603 Peach St. Sentry Medical Technologies 1039 Olivia Ave. Therapy Charts 228 Nickels Arcade Thomson Reuters 777 East Eisenhower Pkwy.

Toxicogenomic Informatics and Solutions, LLC PO Box 27482 Unival, Inc. 2100 Commonwealth Blvd., Ste. 300 Versus Technology, Inc. 2600 Miller Dr. XB Transmed Solutions 3133 Orchard Vista Dr. SE YourSurgery.com 7171 First St.

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B I O S C I E N C E S continued MEDICAL DEVICES Access Medical LLC Accord Biomaterials, Inc. Accumed Systems Inc. Accuri Cytometers, Inc. Adamlab, LLC Advanced Photonix Inc. AI Medical Devices, Inc. Air Force Inc. Akervall Technologies Alivio Corporation American Dental Technologies, Inc. Amigo Mobility International Angott Medical Products, LLC AquaBiochip, LLC ASI Instruments, Inc. Aspen Surgical Products, Inc. ATEK Medical Manufacturing Ateq Corporation Autocam Medical AVAcore Technologies Avalon Laboratories LLC Axsys Technologies, Inc. Azenic Dental, Inc. B.A. Maze, Inc. BarbLock BD Diagnostics (formerly HandyLab Inc.) Becker Orthopedic Bio Logic Engineering, Inc. Bio-Coat, Inc. BioLumix, Inc Biophotonic Solutions, Inc. BioPro Birchbrook Technologies L.L.C. Blaze Medical Devices Bremer Prosthetics, Inc. Brenner Orthotic and Prosthetic Labs CardiArc Cascade Life Solutions CFI Medical Solutions (Contour Fabricators, Inc.) Christian Roux Ltd. Coherix, Inc. College Park Industries Compendia Bioscience Conceivex Corium International, Inc. Covalent Medical, Inc. Coy Laboratory Products Inc. CPR Mattress Critical Signal Technologies Custom Biogenic Systems CVR Global, Inc. Cybernet Medical, Cybernet Systems Corporation CytoPherx Danmar Products Inc. Data Integrated Scientific Systems

1717 Shaffer St., #107 North Professional Bldg.

3550 W. Liberty Rd., Ste. 3 6111 Jackson Road, Ste. 102 173 Parkland Plaza 55 East Long Lake Rd., Ste. 337 2925 Boardwalk 311 Turner Rd. 933 Butternut Dr. 5643 Plymouth Rd. 20429 Honor Hwy. 28265 Beck Rd., Ste. C-22 6693 Dixie Hwy. 442 Five Gaits Ct. 1012 North Walnut St., Ste. 101 12900 E. Ten Mile Rd. 6945 Southbelt SE 620 Watson SW 42000 Koppernick Rd. 4436 Broadmoor SE 333 Parkland Plaza Dr., Ste. 700 301 Michigan St., Ste. 500 2909 Waterview Dr. 259 East Michigan Ave., Ste. 409 43311 Joy Rd. 11590 S. US-31 5230 S. State Rd. 635 Executive Drive 1675 N. Lima Center Rd. 21249 Bridge St. 104 Aprill Dr. 3590 Breezy Point Dr. 2929 Lapeer Rd. 53470 Andrew Circle 9146 Dexter Pinckney Rd. G3487 S. Lindin Rd., Ste. U 32975 West Eight Mile Rd. 7444 Haggerty Rd. 3710 Sysco Ct., SE 14241 Fenton Rd. 598 E. Grand Blvd.

3980 Ranchero Dr. 17505 Helro Rd. 110 Miller Ave., Fl. 2 PO Box 31, 5 East Main St. 4558 50th St. 4750 S. State St., Ste. 301 14500 Coy Drive 200 Michigan St. 22600 Haggerty Road 150 Shafer Dr. 18186 Parke Lane 727 Airport Blvd.

401 W Morgan 221 Jackson Industrial Dr. 8031 Main St., Ste. 301

Kalamazoo, 49048 Ann Arbor, 48103 Ann Arbor, 48103 Ann Arbor, 48103 Troy, 48085 Ann Arbor, 48104 Williamston, 48895 Holland, 49424 Ann Arbor, 48105 Interlochen, 49643 Wixom, 48393 Bridgeport, 48722 Bloomfield Hills, 48304 Lansing, 48906 Warren, 48089 Caledonia, 49316 Grand Rapids, 49504 Canton, 48187 Kentwood, 49512 Ann Arbor, 48103 Grand Rapids, 49503 Rochester Hills, 48309 Kalamazoo, 49007 Canton, 48187 Williamsburg, 49690 Ann Arbor, 48108 Troy, 48083 Dexter, 48130 Southfield, 48034 Ann Arbor, 48103 Okemos, 48864 Port Huron, 48060 New Baltimore, 48047 Pinckney, 48169 Flint, 48507 Livonia, 48152 Canton, 48187 Grand Rapids, 49512 Fenton, 48430 Ypsilanti, 48198 Ann Arbor, 48108 Fraser, 48026 Ann Arbor, 48104 Saranac, 48881 Grand Rapids, 49512 Ann Arbor, 48108 Grass Lake, 49240 Hancock, 49930 Farmington Hills, 48335 Romeo, 48065 Grosse Ile, 48138 Ann Arbor, 48108 Ann Arbor, 48108 Ann Arbor, 48103 Dexter, 48130

269 276-0068 734 995-9089 734 930-0461 734 994-8000 248 362-9603 734 864-5639 517 881-8804 616 399-8511 734 485-2949 231 275-1345 800 359-1959 989 921-5062 248 444-1492 517 402-2692 586 756-1222 888 364-7004 616 643-5200 734 451-9449 800 747-6978 888 282-2673 616 331-5843 248 293-2900 269 349-8870 734 459-5747 231 264-0101 734 663-4719 248 588-7480 734 433-9256 248 352-4570 734 984-3100 517 881-4562 810 982-7777 586 648-8267 734 945-7764 810 733-3375 810 615-0601 734 207-3440 616 977-2515 810 750-5300 734 732-6671 734 922-4066 586 294-7950 734 929-3909 616 452-2700 616 656-4563 734 429-2451 734 475-2200 906 483-2676 888 557-4462 586 331-2600 734 604-6023 800 292-3763 734 272-4772 800 783-1998 734 426-4995

accessmedicaldirect.com accordbiomaterials.com accumedsystemsinc.com AccuriCytometers.com adamlab.com advancedphotonix aimedicaldevices dentalairforce.com akervalltechnologies.com aliviocorp.com americandentaltech.com myamigo.com N/A aquabiochip.com asi-instruments.com aspensurgical.com atekcompanies.com atequsa.com autocam-medicalkk.com avacore.com avalonlabs.com axsys.com N/A purrfectopener.com barblock.com handylab.com beckerorthopedic.com biologicengineering.com N/A mybiolumix.com biophotonicsolutions.com bioproimplants.com birchtek.com N/A bremerprosthetics.com N/A cardiarc.com N/A cfimedical.com hurricanecrutch.com coherix.com college-park.com compendiabio.com conceptionkit.com coriumintl.com covamed.com coylab.com cprmattress.com criticalsignaltechnologies.com custombiogenics.com cvrglobal.com cybernetmedical.com cytopherx.com danmarproducts.com dissdata.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B iosciences continued MEDICAL DEVICES continued Davis Dental Labs DavisMade, Inc. Diagnostic Instruments Inc. Diamond General Digilab Genomic Solutions DNADNB LLC DuPeron Medical Systems EADevices, Inc. ECO PHYSICS, INC. EdgeHealth LLC Ennew Medical Devices, LLC Epsilon Imaging Inc. Essen Bioscience EyeLab Group FlowTech Corporation Fluid Insights LLC Freeman Manufacturing Company Garrison Dental Solutions Gema Diagnostics Grant Manufacturing Corporation Green BioWorks HAC of America, Inc. Hamztec LLC Hanger Prosthetics & Orthodics Hart Enterprises Haworth, Inc. Helvetia Development Company LLC Herman Miller Inc HistoSonics, LLC HoMedics Hygieia, Inc. Implants International N.A. In the Groove, LLC Incept BioSystems InnerSpace Corporation InnoMotus LLC Innovational Therapeutics Innovative BioTherapies, Incorporated INRAD, Inc. Integrated Sensing Systems (ISSYS) INVIA Medical Imaging Solutions IPGDx LLC Johnson & Johnson KOA Orthopedics Koch’s Orthotics and Prosthetics Lake Erie Wholesale Medical Supply LaMed, Inc Laser Mechanisms, Inc. / Oxid Corporation LDI Incorporated, ETO MAGNETIC Corp., LDI, Inc. Life Magnetics Lift Aid Lodox PTY LTD L-VAD Technologies, Inc. Lynn Medical Instruments Mager Scientific MarketLab MedArray, Inc.

5830 Crossroad, Commerce Parkway 2511 Davison Rd. 6540 Burroughs St. 333 Parkland Plaza Dr. 4355 Varsity Dr., Ste. E 4995 Arrowhead Rd. 515 N. Washington Ave. 7752 Primrose Lane 3915 Research Park, Suite A-3 217 Third Street 2400 N. 6th Street 3917 Research Park Drive, Suite B7 1156 Oak Valley Drive 2350 Washtenaw, Suite 4 7601 Stadium Drive 4995 Arrowhead Road 900 W. Chicago Rd. 150 DeWitt Lane 463 Rosewood Avenue 10957 Old 27 Hwy N. 330 East Liberty St., Lower Level 1111 West Centre Ave. 1039 Olivia Ave. 2314 Gull Road 400 Applejack Court One Haworth Center 225 Parsons Street 855 East Main Ave., PO Box 302 7819 Kilbirnie Drive 3000 North Pontiac Trail 330 E. Liberty Street, Lower Level 220 E. Huron St., 3rd Floor 7600 Madeline Street 401 W. Morgan Rd. P.O. Box 2186 3710 Frains Lake 1404 Cambridge Road 401 W. Morgan Rd. 4375 Donker Ct. SE 391 Airport Industrial Drive 3025 Boardwalk Street, Suite 200 P.O. Box 253 P.O. Box 726 46985 Enterprise Drive, Suite A-100 5315 Elliot Drive, Suite 104 7560 Lewis Avenue 54283 Meadowood Court, Suite 610 25275 Regency Dr. 4311 Patterson S.E. N/A 50714 Century Ct. 23360 Clarkshire 300 River Place, Suite 6850 P.O. Box 930459 1100 Baker Rd. P.O. Box 888374 3915 Research Park Dr., Suite A-4

Wyoming, 49519 616 261-9191 Flint, 48506 810 742-0581 Sterling Heights, 48314 586 731-6000 Ann Arbor, 48103 800 678-9856 Ann Arbor, 48108 734 975-4800 West Bloomfield, 48323 248 682-3368 Saginaw, 48607 800 383-8479 Portage, 49024 412 334-7045 Ann Arbor, 48108 734 998-1600 Ann Arbor, 48103 734 622-8060 Kalamazoo, 49009 269 615-5113 Ann Arbor, 48108 734 369-5100 Ann Arbor, 48108 734 769-1600 Ann Arbor, 48104 734 665-0567 Kalamazoo, 49009 269 375-1290 West Bloomfield, 48323 248 682-3368 Sturgis, 49091 616 651-2371 Spring Lake, 49456 616 842-2430 East Lansing, 48823 517 775-3007 Vanderbilt, 49795 989 983-3641 Ann Arbor, 48104 734 276-4764 Kalamazoo, 49024 800 445-9968 Ann Arbor, 48104 734 476-8502 Kalamazoo, 49001 269 345-1117 Sparta, 49345 616 887-0400 Holland, 49423 616 393-3000 Kalamzoo, 49007 877 626-5704 Zeeland, 49464 616 654-3000 Portage, 49024 269 270-4387 Commerce Twp, 48390 248 863-3000 Ann Arbor, 48104 734 527-9160 Ann Arbor, 48104 N/A Saginaw, 48609 517 781-6030 Ann Arbor, 48108 317 508-6972 Grand Rapids, 49501 616 224-2828 Ann Arbor, 48105 N/A Ann Arbor, 48104 734 914-0550 Ann Arbor, 48108 734 213-8350 Kentwood, 49512 616 301-7800 Ypsilanti, 48198 734 547-9896 Ann Arbor, 48108 734 205-1231 Harrisville, 48740 989 724-5631 Langhorne, PA 19047 N/A Wixom, 48393 248 596-0250 Ypsilanti, 48197 734 434-0442 Temperance, 48182 734 847-3847 Shelby Township, 48316 248 650-0476 Novi, 48375 248 474-9817 Grand Rapids, 49512 N/A Ann Arbor 734 277-2378 Wixom, 48393 248 348-1000 South Lyon, 48178 248 446-8480 Detroit, 48207 313 446-2800 Wixom, 48393 248 560-4500 Dexter, 48130 734 426-3885 Kentwood, 49588 616 656-2484 Ann Arbor, 48108 734 769-1066

dentalservices.net/davis standingdani.com diaginc.com diamondgeneral.com genomicsolutions.com N/A duperon.com eadevices.com ecophysics-us.com N/A N/A epsilon-imaging.com essen-instruments.com N/A flowtechfilters.com N/A freemanmfg.com garrisondental.com gemadiagnostics.com granthealingenvironment.com greenbioworks.com hacofamerica.com N/A hanger.com hartneedles.com haworth.com conformamed.com hermanmiller.com N/A homedics.com N/A implantsinternational.com inthegroovebrace.com inceptbio.com stanleyinnerspace.com N/A innbio.com inrad-inc.com mems-issys.com inviasolutions.com ipgdx.com jnj.com koaorthopedics N/A N/A lamedinc.com Oxid.com ldiinc.com lifemagnetics.com liftaid.com lodox.com lvadtech.com lynnmed.com magersci.com marketlabinc.com permselect.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B I O S C I E N C E S continued MEDICAL DEVICES continued MedBio, Inc. MedElute, Inc. Medical Accessories & Research Corporation Medical Imaging Resources, Inc. MedImage, Inc. Medi-Nuclear Corp.

MediQuest Life Sciences, LLC Medtronic MemsTech MERS, LLC MI4Spine, LLC Michigan Critical Care Consultants, (MC3) Inc. Michigan Instruments Michigan Orthodontic Appliances Michigan Orthopedic Services Michigan Surgical Equipment LLC Micro Machine Company Midbrook, Inc. Miller Technical Services Mitchell Home Medical Monteris Medical, Inc. Mt. Clemens Orthopaedic Appliances, Inc. M-Vision Nalge Nunc International Nanoderm Therapeutics, Inc. NeuroNexus Technologies, Inc. Next Generation Therapeutics, Inc NEXT Mobility Northwest Orthotics-Prosthetic, Inc. Norwind-Cortez NuStep OcuSciences, Inc. Omega Surgical Instruments, Inc. Oncologix Tech Optical Dimensions Optical Supply Orchid Bio-Coat Orthopedic Solutions Orchid Bio-Vac Orthopedic Solutions Orchid Stealth Orchid Unique Orthopedic Solutions Orthopedic Development, Inc. Ostial Solutions Pall Corporation - Life Sciences PBS Biotech Performace Systematix Inc. Phadia US Physician Technology, LLC PICOCAL Pioneer Surgical Technology Pixel Velocity Inc. Plas-Labs, Inc. Precision Edge Surgical Products Progressive Dynamics Medical Pros-Tech Prosthetic Center, Inc Proud Mary Prosthetics

630 S. Division Ave. 259 East Michigan Ave., Suite 407 219 North Church Street 120 Enterprise Dr. 6276 Jackson Road, Suite G 3029 Research Dr. 42030 Koppernick Road 620 Watson Street SW 42503 Steepleview 799 Skynob Dr. 1070 Timberlake Dr. 3550 W. Liberty, Suite 3 4717 Talon Ct. SE 1013 East 3rd Street 13450 Farmington Road 48797 West Road 2429 North Burdick St. 2080 Brooklyn Rd. 7444 Haggerty Rd. 3430 Washtenaw 4664 Campus Drive 24432 Crocker Blvd.

12420 Stanley Drive 9680 Oakhill Rd. 3081 N. Foxridge Ct. 3985 Research Park Drive, Suite 100 46701 Commerce Center Dr., Suite A-6 7444 Haggerty Rd. 39830 Grand River, Suite BLD 305 North Hewitt 5111 Venture Drive, Ste. 1 3201 Asher Rd. G-8395 S. Saginaw Street P.O. Box 8832 711 East 4th Street 1526 Plainfield Ave, NE 21249 Bridge Street 21316 Bridge Street 1489 Cedar St. 6688 Dixie Highway 6565 West Main St. 1111 Short Road 600 S. Wagner Road 2843 E. Grand River Avenue, Suite 262 5569 33rd Street, SE 4169 Commercial Avenue 23 East Front Street 333 Parkland Plaza 375 River Park Circle 3917 Research Park Drive Suite 1B 401 E. North Street 415 W. 12th Avenue 507 Industrial Road 1717 Stephenson Hwy. 1200 S. Washington Avenue 6305 Wall St.

Grand Rapids, 49503 616 245-0214 Kalamazoo, 49007 269 352-3760 Zeeland, 49464 616 748-8950 Ann Arbor, 48103 734 426-3003 Ann Arbor, 48103 734 665-5400 New Hudson, 48165 800 423-4266 Canton, 48187 734 455-7110 Grand Rapids, 49504 616 242-5200 Northville, 48167 734 560-5506 Ann Arbor, 48105 734 487-1251 Bloomfield Hills, 48302 248 535-6953 Ann Arbor, 48103 734 995-9089 Grand Rapids, 49512 616 554-9696 Royal Oak, 48067 248 544-0860 Livonia, 48150 734 513-8205 Wixom, 48393 248 349-5859 Kalamazoo, 49007 269 388-2440 Jackson, 49203 517 787-3481 Canton, 48187 734 207-2600 Ann Arbor, 48104 734 477-0202 Kalamazoo, 49008 269 372-0455 Clinton Township, 48036 586 463-3600 Belleville, 48111 734 697-3933 Holly, 48442 248 842-8620 Ann Arbor, 48105 734 665-4105 Ann Arbor, 48108 734 913-8858 Plymouth, 48170 734 527-9139 Canton, 48187 888 489-6398 Novi, 48375 248 477-1443 Ypsilanti, 48197 734 434-0575 Ann Arbor, 48108 734 769-3939 Ann Arbor, 48104 734 646-4156 Grand Blanc, 48439 800 656-6342 Grand Rapids, 49518 616 977-9933 Royal Oak, 48067 248 541-3790 Grand Rapids, 49505 616 361-6000 Southfield, 48034 248 352-4570 Southfield, 48033 248 350-2150 Holt, 48842 517 694-2300 Bridgeport, 48772 989 746-0780 Kalamazoo, 49009 269 544-4715 Kalamazoo, 49008 269 383-3797 Ann Arbor, 48103 800 521-3160 Okemos, 48823 N/A Grand Rapids, 49512 616 949-9090 Portage, 49002 800 346-4364 Monroe, 48161 419 944-8722 Ann Arbor, 48103 N/A Marquette, 49855 906 226-9909 Ann Arbor, 48108 734 213-3715 Lansing, 48906 517 372-7177 Sault Ste Marie, 49783 906 632-4800 Marshall, 49068 269 781-4241 Troy, 48083 248 680-2800 Lansing, 48910 517 372-7007 Sterling Heights, 48312 877 627-9272

medbioinc.com N/A medacc.com mobileleasing.com medimage.com medinuc.com/index.html mediquestlifesciences.com medtronic.com memstech.com mersllc.com mi4spine.e-shopmall.com mc3corp.com michiganinstruments.com N/A michortho.com michigansurgical.com micromachineco.com midbrook.com ctsmius.com mitchellhomemedical.com monteris.com N/A m-visioninc.com nalgenunc.com/default.asp N/A neuronexustech.com nextgenerationtherapeutics.com nextmobilitynow.com N/A N/A nustep.com ocusciences.com omegasurgical.com N/A opticaldimensionslab.com/default.aspx optical-supply.com orchid-orthopedics.com/biocoat orchid-orthopedics.com/biovac orchid-orthopedics.com orchid-orthopedics.com/unique N/A ostialsolutions.net pall.com pbsbiotech.com psix.com phadia.us willomd.com picocal.com pioneersurgical.com pixel-velocity.com plas-labs.com precisionedge.com progressivedynamicsmedical.com pros-tech.com N/A proudmaryprosthetics.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B iosciences continued MEDICAL DEVICES continued Ranir, LLC 4701 East Paris Avenue SE Grand Rapids, 49518 616 698-8880 ranir.com Rapid BioSense 3900 Collins Road Lansing, 48910 800 579-4913 rapidbiosense.com RealBio Technology, Inc. 4717 Campus Drive, Suite 1500 Kalamazoo, 49008 269 544-1088 realbiotechnology.com Renko Enterprises, LLC 25344 Carollton Drive Farmington Hills, 48335 248 342-6472 N/A RG Medical Diagnostics 28351 Beck Rd., Suite G5 Wixom, 48393 888 596-9498 rgmd.com Richard-Allan Scientific 4481 Campus Dr. Kalamazoo, 49008 616 644-2400 rallansci.com Rigaku Innovative Technologies 1900 Taylor Road Auburn Hills, 48326 248 232-6400 rigaku.com RJL Systems, Inc. 33939 Harper Avenue Clinton Township, 48035 586 790-0200 rjlsystems.com Rockwell Medical Technologies, Inc. 30142 Wixom Road Wixom, 48393 800 449-3353 rockwellmed.com Rose Technologies 1440 Front Avenue NW Grand Rapids, 49504 616 233-3000 rose-technologies.com Roush Life Sciences 12447 Levan Livonia, 48150 734 779-7006 roush.com Rubicon Genomics, Inc. 4355 Varsity Drive, Suite E Ann Arbor, 48108 734 677-6210 rubicongenomics.com RxDispense, Inc. 2706 Cumberland Berkley, 48072 734 277-0668 rxdispense.com Sakor Technologies, Inc. 2855 West Jolly Rd. Okemos, 48864 517 332-7256 sakor.com Selective Technologies, Inc. 132 West First St. Flint, 48502 810 767-7530 N/A SenSound, LLC 440 Burroughs St., Suite 170 Detroit, 48202 313 882-1065 sensound.com Siemens Ultrasound Division 400 W. Morgan Ann Arbor, 48108 734 995-5010 usa.siemens.com Signal Medical Corporation 400 Pyramid Marysville, 48040 810 364-7070 signalmd.com SkinTreet, LLC 1120 Olivia Avenue Ann Arbor, 48104 734 663-5999 N/A Skytron 5085 Corporate Exchange Blvd.

Grand Rapids, 49512 800 759-8766 skytron.us Slaughter Instrument Co. 4356 North Roosevelt Stevensville, 49127 269 428-7471 slaughtercoinc.com SoloHill Engineering, Inc. 4370 Varsity Drive, Suite B Ann Arbor, 48108 734 973-2956 solohill.com Somanetics Corporation 2600 Troy Center Dr. Troy, 48084 248 244-1400 somanetics.com Sonetics Ultrasound, Inc. 3550 W. Liberty, Ste. 3 Ann Arbor, 48103 734 260-4800 N/A Sononir Technology LLC N/A Muskegon N/A N/A Spartan Medical Supply 50762 Kiawah Trail Mattawan, 49071 866 894-5118 spartanmedicalsupply.com Stryker Corporation 2825 Airview Boulevard Kalamazoo, 49002 616 385-2600 stryker.com Stryker Instruments 4100 East Milham Avenue Kalamazoo, 49001 269 323-7700 stryker.com/instruments Stryker Interventional Pain 2825 Airview Boulevard Kalamazoo, 49002 269 385-2600 stryker.com/en-us/products/

PainManagement/index.htm stryker.com/en-us/corporate/ContactUs/ Stryker Orthopaedics 44736 Helm St. Plymouth, 48170 734 454-0023

Orthopaedics/index.htm Stryker Osteosynthesis 2825 Airview Boulevard Kalamazoo, 49002 osteosynthesis.stryker.com Surge Medical Solutions 3710 Sysco Ct. SE Grand Rapids, 49512 616 949-2392 surgemedical.com SurgiTel 77 Enterprise Drive Ann Arbor, 48103 734 996-9200 surgitel.com Symmetry Jet 5212 Aurelius Road Lansing, 48911 517 882-4311 symmetrymedical.com Systems Specialties 390 Enterprise Court, Suite 200 Bloomfield Hills, 48302 248 332-0099 sysspec.com Tangent Medical Technologies, LLC 2132 Packard St. Ann Arbor, 48104 800 664-7612 tangentmedical.com Tech Initiatives Inc. 200 Michigan Street, Suite 408 Hancock, 49930 906 483-2676 cprmattress.com Teclab 6450 Valley Industrial Drive Kalamazoo, 49009 269 372-6000 teclab.com Tekna 3400 Tech Circle Kalamazoo, 49008 269 978-3500 teknalink.com Terumo Cardiovascular Systems 6200 Jackson Road Ann Arbor, 48103 800 262-3304 terumo-cvs.com Terumo Heart, Inc. 6180 Jackson Road Ann Arbor, 48103 734 741-6114 terumoheart.com The Tech Group 3116 N. Wilson Ct. NW Walker, 49534 616 643-6001 techgroup.com Thompson Surgical Instruments 10170 E Cherry Bend Rd Traverse City, 49684 231 922-0177 thompsonsurgical.com Tissue Regenerating Systems 401 West Morgan Ann Arbor, 48108 N/A N/A Topspins, Inc. 403 Riverview Dr. Ann Arbor, 48104 734 623-6400 topspins.com TouchStone Innovations 1039 Olivia Ave. Ann Arbor, 48104 734 476-8502 N/A Troy Biologicals, Inc. 1238 Rankin St Troy, 48083 800 521-0445 troybio.com Twin Bay Medical, Inc. 11590 S. US-31 Williamsburg, 49690 231 264-0101 twinbaymedical.com Ultralight Prosthetics, Inc. 24781 Five Mile Road Redford, 48239 313 538-8500 ultralightprosthetics.com Ultrasound Medical Devices, Inc. 3917 Research Park, Suite B-7 Ann Arbor, 48108 734 369-5056 N/A Versus Technology, Inc. 2600 Miller Creek Drive Traverse City, 49684 231 946-5868 versustech.com Vigor Therapy Solutions 4915 Advance Way Stevensville, 49127 269 429-0191 vigorequipment.com Waters 2805 S. Industrial Ann Arbor, 48104 734 761-9600 waters.com Wizard Med LLC 48223 Chesterfield Canton, 48187 734 536-1602 wizardmed.com Wright & Filippis, Inc. 2845 Crooks Rd. Rochester Hills, 48309 248 853-1888 firsttoserve.com Xoran Technologies, Inc. 5210 South State Road Ann Arbor, 48108 734 663-7194 xorantech.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B iosciences continued research & development Absolute Laboratories Inc. 240 W. Auburn Rd. ADMETRx 4717 Campus Dr. Ann Arbor Clinical Research 203 South Zeeb Rd., Ste. 105 Antel BioSystems, Inc. 3655 Forest Rd. ApoLife, Inc. 100 River Pl., #6850 Aptuit Consulting, Inc 91 Hartwell Ave. Arbor Preclinical & Consulting, LLC 8975 S. Ave E Arbor Research Collaborative for Health 315 W. Huron St., Ste. 360 Arbor-Biotech LLC N/A ASC Inc. 1945 Pauline Blvd.

ASI Instruments, Inc. 12900 E. 10 Mile Rd. Assay Designs, Inc. 5777 Hines Dr. Asterand plc TechOne Building, 440 Burroughs, Ste. 501 AzoRx, Inc. 526 Jasper St. Beaumont Commercialization Center 3601 West 13 Mile Rd. Bio-Chem Laboratories, Inc. 1049 28th St., SE Biodiscovery, LLC 5692 Plymouth Rd. BioPharma Data Services 1461 Scio Ridge Ct BioSTAT Consultants, Inc. 528 West Centre Ave. Bridge Organics Co. 311 West Washington St. CeeTox, Inc. 4717 Campus Dr., Ste. 500 Cell Culture Characterization Services 1872 North Adams Charles River 9801 Shaver Rd. ClinSite, Inc. 24 Frank Lloyd Wright Dr., Lobby A ClinXus Cook-DeVos Center for Health Sciences

301 Michigan St. NE, Ste. 520 CNVGenes LLC 4995 Arrowhead Rd. Coherix, Inc. 3980 Ranchero Dr. Covance Research Products 6321 South 6th St. Crissman Toxicologic Pathology, LLC 2887 Oakhaven Ct. Cutting Image Histology, LLC 800 Technology Dr. DBA Analytical (an NSF International Co.) 789 Dixboro Rd. Detroit R & D, Inc. Metropolitan Center for High Technology

2727 Second Ave, Ste. 4113 DNA Software, Inc. 334 East Washington St. Emil’s Molecular Design, LLC 8772 Trillium Dr Essen Instruments 1156 Oak Valley Dr. Eurofins Avtech Laboratories, Inc. 6859 Quality Way Exponent, Inc. 39100 Country Club Dr. Ferndale Pharma Group 780 West 8 Mile Rd. Genemarkers LLC 4280 Commercial Ave., Ste. A. Giri Diagnostics LLC 2611 Parmenter Blvd.

Global Clinical Connections MTEC at the Groves at KVCC

7107 Elm Valley Dr., Ste. 2680 Global Remediation Technologies Inc. 1102 Cass St. Global Strategic Connections, LLC 2125 Butterfield Dr., Ste. 218 Grand River Aseptic Pharmaceutical Packaging, Inc. PO Box 3696 Great Lakes Drug Development, Inc. 1032 Karl Greimel Dr., Ste. 11 Housey Pharmaceutical Research Laboratories, LLC 16800 W 12 Mile Rd., Ste. 201 i3 STATPROBE, Inc. 300 W. Morgan Rd. Inland Waters Pollution Control 2021 South Schaefer Hwy. Innovative Research Inc. 46430 Peary Ct. Integrated Nonclinical Development Solutions, Inc. (INDS) 3005 Miller Ave. International Discovery Sourcing Consultants LLC 300 N. Main St., Ste. 202 Intervention Insights 710 Kenmoor, Ste. 120 Jasper Clinical Research & Development, Inc. 526 Jasper St. JB Laboratories 13295 Reflections Dr.

Rochester Hills, 48307 Kalamazoo, 49008 Ann Arbor, 48103 Lansing, 48910 Detroit, 48207 Lexington, MA, 02421 Scotts, 49088 Ann Arbor, 48103 Ann Arbor Ann Arbor, 48103 Warren, 48089 Ann Arbor, 48108 Detroit, 48202 Kalamazoo, 49007 Royal Oak, 48073 Grand Rapids, 49508 Ann Arbor, 48105 Ann Arbor, 48103 Portage, 49024 Vicksburg, 49097 Kalamazoo, 49008 Rochester Hills, 48306 Portage, 49002 Ann Arbor, 48106 Grand Rapids, 49503

877 343-5227 269 372-3272 734 926-0957 800 631-3510 313 446-2625 617 538-5688 734 330-4396 734 665-4108 734 622-1910 734 480-2952 586 756-1222 734 668-6113 313 263-0960 269 585-5953 248 551-2667 616 248-4900 734 998-0751 734 255-1038 269 329-7976 616 649-4200 269 353-5555 248 656-2542 269 327-4248 734 930-3700 616 331-5854

absolutelabs.net admetrx.com annarborclinicalresearch.com antelbio.com apolife.com aptuitconsulting.com arborpcc.com arborresearch.org N/A asc-inc.net asi-instruments.com assaydesigns.com asterand.com azorx.com beaumontcommercializationcenter.com bio-chem.com/Home/tabid/36/Default.aspx Mycroarray.com BioPharmaDataServices.com biostat.net/ bridgeorganics.com ceetox.com cellcharacterization.com criver.com clinsite.com clinxus.org

West Bloomfield, 48323 Ann Arbor, 48108 Kalamazoo, 49009 Midland, 48642 Ann Arbor, 48108 Ann Arbor, 48113 Detroit, 48201

248 682-3368 734 922-4066 269 375-0482 989 631-2790 734 945-9077 734 769 8010 313 961-1606

cnvgenes.com coherix.com crpinc.com N/A cuttingimagehistology.com dba- global.com detroitrandd.com

Ann Arbor, 48104 Ypsilanti, 48197 Ann Arbor, 48108 Kalamazoo, 49002 Farmington Hills, 48331 Ferndale, 48220 Portage, 49002 Royal Oak, 48073 Kalamazoo, 49009

734 222-9080 N/A 734 769-1600 269 323-3366 248 324-9135 248 548-0900 269 998-8116 248 435-4472 269 488-3277

dnasoftware.com N/A essen-instruments.com avtechlabs.com exponent.com ferndalelabs.com genemarkersllc.com giridiagnostics.com globalclinicalconnections.com

Traverse City, 49684 Troy, 48084 Grand Rapids, 49501 Brighton, 48116 Southfield, 48076 Ann Arbor, 48108 Detroit, 48217 Novi, 48377 Ann Arbor, 48103 Chelsea, 48118 Grand Rapids, 49546 Kalamazoo, 49007 Holland, 49424

800 899-3703 248 816-6881 616 331-6980 810 224-7500 248 663-7000 734 769-5000 800 992-9118 248 896-0145 734 929-5392 734 433-9670 616 949-7500 269 276-8899 616 738-8500

grtusa.com gsc-llc.com GranDr.rAPP.com gldrugdev.com housey.com i3statprobe.com inlandwaters.com innov-research.com INDS-Inc.com idscbiotechnetwork.com interventioninsights.com jasperclinic.com jblabs.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B iosciences continued research & development continued JV Biolabs 2245 S. State St. Ann Arbor, 48104 734 395-8891 Kalexsyn, Inc. 4502 Campus Dr. Kalamazoo, 49008 269 488-8488 KAR Bioanalytical, Inc. 4425 Manchester Rd. Kalamazoo, 49001 269 381-9666 Kendle International 315 E. Eisenhower Pkwy, Ste. 214 Ann Arbor, 48108 734 274-8500 Keystone Solutions Group 5121 East ML Ave., Ste. B-10 Kalamazoo, 49048 269 343-4108 Lead Biopharma Consulting, LLC 7726 Brass Creek Ct. Dexter, 48130 734 418-2296 LexaMed, Ltd. 705 Front St. Toledo, OH 43605 419 693-5307 Maximax Pharmaceutical Research 35560 Grand River, Ste.# 292 Farmington Hills, 48335 800 374-5270 MBI International 3900 Collins Rd. Lansing, 48910 517 337-3181 McClinchey Histology Lab, Inc P.O. Box 421, 100 Rice St. Stockbridge, 49285 517 851-9149 Merit Laboratories, Inc. 2680 E. Lansing Dr. East Lansing, 48823 517 332-0167 Michigan Animal Model Consortium 333 Bostwick Ave. Grand Rapids, 49503 616 234-5684

Michigan Antibody Technology Center - Center of 333 Bostwick Ave. Grand Rapids, 49503 616 234-5342 Technology Excellence Michigan Biological Imaging Center Dept. of Biological Sciences, 3425 Woodhall, WMU Kalamazoo, 49008 269 387-5640 Michigan Center for Biological Information 3600 Green Ct., Ste. 700 Ann Arbor, 48105 Michigan Center for Structural Biology, MSU Dept. of Biochemistry, 310 A Biochemistry East Lansing, 48824 517 355-0199 Michigan Critical Care Consultants, (MC3) Inc. 3550 W. Liberty, Ste. 3 Ann Arbor, 48103 734 995-9089 Michigan Diagnostics LLC 2611 Parmenter Blvd.

Royal Oak, 48073 248 435-4472 Michigan High Throughput Screening Center - Kalamazoo Valley Community College Kalamazoo, 49009 269 353-1582 Center of Technology Excellence 7170 Elm Valley Dr. Michigan Proteome Consortium 300 North Ingalls Bldg., 11th Fl., Rm. 1198 Ann Arbor, 48109 734 763-3130 Michigan Technology and Research Institute, LLC 2245 South State St., Ste. 1100 Ann Arbor, 48104 734 222-0013 Micro Machine Company 2429 North Burdick St. Kalamazoo, 49007 269 388-2440 Microbiological Associates, Inc. 37428 Hills Tech Dr. Farmington Hills, 48331 248 324-4800 Micromyx, LLC 4717 Campus Dr. Kalamazoo, 49008 269 372-3758 Milad Pharmaceutical Consulting 46701 Commerce Center Dr, Ste. D Plymouth, 48170 734 664-0394 MIR Preclinical Services (Molecular Imaging Research) 800 Technology Dr. Ann Arbor, 48108 734 821-1063 MitoStem 440 Burroughs Detroit, 48202 313 483-0385 MMS Holdings, Inc. 6880 Commerce Blvd.

Canton, 48187 734 245-0310 Molecular Innovations Inc. 46430 Peary Ct. Novi, 48377 888 557-5055 MPI Research 54943 North Main St. Mattawan, 49071 269 668-3336 NextGen Sciences, Inc. 4401 Varsity Dr., Ste. E Ann Arbor, 48108 734 973-7914 Northern Biomedical Research, Inc. 930 W. Sherman Blvd.

Muskegon, 49441 231 759-2333 Oakland Genetics LLC 2925 Bond Rochester Hills ,48309 248 257-0000 Ophthigenics LLC 2900 Huron Pkwy. Ste. 4 Ann Arbor, 48105 734 945-5408 Ophthy-DS, Inc. 54943 N. Main St. Mattawan, 49071 269 250-2177 Orchid Unique Orthopedic Solutions 6688 Dixie Hwy. Bridgeport, 48772 989 746-0780 Originus, Inc. 3985 Research Park Dr., Ste. 200 Ann Arbor, 48108 734 913-8791 Oxford Biomedical Research, Inc. 2165 Avon Industrial Dr. Rochester Hills, 48309 248 852-8815 Paragon Laboratories, Inc. 12649 Richfield Ct. Livonia, 48150 734 462-3900 Pathology Experts, LLC 2887 Oakhaven Ct. Midland, 48642 989 631-2790 Penn Pharmaceutical Services 10230 W. 50 N Columbus, IN 48201 812 342-3528 PharmOptima, LLC 6710 Quality Way Portage, 49002 269 329-4370 Phillips Plastics Corp.

5706 Stonington Ct. West Bloomfield, 48322 248 851-8300 PhycoTech 620 BRd. St., Ste. 100 St. Joseph, 49085 616 983-3654 Proteos, Inc. 4717 Campus Dr. Kalamazoo, 49008 269 372-3423 Quantum Laboratories 28221 Beck Rd., Ste. A-11 Wixom, 48393 248 348-7029 Quest Research Institute 31000 Telegraph, Ste. 230 Bingham Farms, 48025 248 644-7770 Regional Medical Lab, Inc 175 College St. Battle Creek, 49037 269 969-6161 RTI Health Solutions 3005 Boardwalk St., Ste. 105 Ann Arbor, 48108 734 213-5372 RTI Laboratories, Inc. 31628 Glendale St. Livonia, 48150 734 422-8000 Rubicon Genomics, Inc. 4355 Varsity Dr., Ste. E Ann Arbor, 48108 734 677-6210 S & J Laboratories 4669 Executive Dr. Portage, 49002 269 324-7383 SciTech Development 281 Kercheval Grosse Pointe Farms, 48236 313 576-8263 Secretory IgA Inc. 803 N. Main St. Ann Arbor, 48104 734 994-0966

jvbiolabs.com kalexsyn.com karbio.com kendle.com keystone-pd.com leadbiopharma.com lexamed.net maximax.com mbi.org mhistolab.com meritlabs.com ctaalliance.org/cta-cores/michigananimal-model-consortium ctaalliance.org/cta-cores/michiganantibody-technologies-core wmich.edu/bios/facilities/imaging-center ctaalliance.org/MCBI mcsb.bch.msu.edu mc3corp.com michdiag.com mhtsc.kvcc.edu proteomeconsortium.org MTRInstitute.com micromachineco.com microbioassociates.com micromyx.com miladpharmaconsulting.com molecularimaging.com N/A mmsholdings.com mol-innov.com mpiresearch.com nextgensciences.com N/A oaklandgenetics.com ophthigenics.com Ophthy-DS.com orchid-orthopedics.com/unique originusinc.com oxfordbiomed.com paragonlaboratories.com pathexperts.com pennpharm.com pharmoptima.com phillipsplastics.com phycotech.com proteos.net quantumlaboratories.com questri.com rml-lab.com rtihs.org rtilab.com rubicongenomics.com sandjlab.com scitechdevelopment.com secretoryiga.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B iosciences continued research & development continued Sequenom Center for Molecular Medicine Shrader Analytical and Consulting Laboratories, Inc. SoloHill Engineering, Inc. Technology Partnership Therapeutics Systems Research Laboratories, Inc. Tolera Therapeutics, Inc. TouchStone Innovations Toxicogenomic Informatics and Solutions, LLC TransPharm Preclinical Solutions, LLC Troy Polymers United BioSource Corp.

Velesco Pharmaceutical Services VetGen, LLC Warde Medical Laboratory Wayne State University Applied Genomics Technologies

West Michigan Regional Laboratory Working Bugs, LLC

301 Michigan St. NE, Ste. 580 440 Burroughs, Ste. 340 4370 Varsity Dr., Ste. B 8030 Coventry 540 Avis Dr., Ste. A 350 E. Michigan Ave., Ste. 205 1039 Olivia Ave. P.O. Box 27482 7190 Brooklyn Rd. 330 E. Maple, Ste. L 2200 Commonwealth Blvd., Ste. 100 46701 N. Commerce Center Dr. 3728 Plaza Dr., Ste. 1 300 W. Textile Rd. WSU-5197, Biological Science Bldg., 5047 Gullen Mall 1726 Knollcrest Circle SE 16647 Chandler Rd.

Grand Rapids, 49503 Detroit, 48202 Ann Arbor, 48108 Grosse Ile, 48138 Ann Arbor, 48108 Kalamazoo, 49007 Ann Arbor, 48104 Lansing, 48909 Jackson, 49201 Troy, 48083 Ann Arbor, 48105 Plymouth, 48170 Ann Arbor, 48108 Ann Arbor, 48108 Detroit, 48202

616 391-4330 313 894-4440 734 973-2956 313 675-8295 734 663-4233 269 585-2100 734 476-8502 N/A 517 536-8210 248 733-1030 734 994-8940 734 545-0696 734 669-8440 734 214-0300 313 577-3555

cmmdx.org shraderlabs.com solohill.com N/A tsrlinc.com tolera.com N/A txisllc.com transpharmsite.com troypolymers.com unitedbiosource.com velescopharma.com vetgen.com wardelab.com bioinformatics.wayne.edu/MCGT

Grand Rapids, 49546 East Lansing, 48823

616 526-8440 517 203-4744

calvin.edu/admin/wmrl/ workingbugs.com

Pharmaceuticals 21st Century Therapeutics, Inc. AAPharmaSyn LLC Aastrom Biosciences, Inc. Abbott Nutrition Access Business Group Adeona Pharmaceuticals ADMETRx AFID Therapeutics Inc. Albemarle Corp.

Alluvium Biosciences AlphaCore Pharma Amgen Aptuit Consulting, Inc Arbor Assay Armune Biosciences, Inc. Ash Stevens Assay Designs, Inc. Asterand plc Auburn Pharmaceutical Co. AureoGen Biosciences, Inc. Aursos, Inc. Bauer BioMedical, LLC Bayer Health Care BD Diagnostics (formerly HandyLab Inc.) Becton Dickinson - Difco Laboratories Berry & Associates, Inc. Biodiscovery, LLC Biomedical Diagnostics, LLC Biomide Biopelle Biopolymer Innovations Biosol, Ltd. BoroPharm, Inc. Bridge Organics Co. Cancer Stem Cell Genomics Caraco Pharmaceutical Laboratories, Ltd. Cayman Chemical Company

52673 Seven Oaks, Ste. 105 3985 Research Park Dr. 24 Frank Lloyd Wright Dr., Lobby K 901 North Centerville Rd. 7575 Fulton St. East 3930 Varsity Dr. 4717 Campus Dr. 3900 Collins Rd., Ste. 1029 1421 S. Kalamazoo St. 789 N. Dixboro Rd. 333 Parkland Plaza, Ste. 5 9935 N. Valley Hill Dr. 91 Hartwell Ave 1514 Eisenhower Pl. 350 East Michigan Ave., Ste. 500 5861 John C. Lodge Fwy. 5777 Hines Dr. TechOne Building, 440 Burroughs, Ste. 501 1775 John R Rd. 6475 Technology Ave., Ste. C 350 East Michigan Ave, Ste. 500 2625 Denison Dr. 6549 Braemer Ave. 5230 S. State Rd. 920 Henry St. 2434 Bishop Circle E. 5692 Plymouth Rd. 5692 Plymouth Rd., Ste. B 21 Kercheval Ave., Ste. 330 780 W. 8 Mile Rd. 16647 Chandler Rd. 206 Fifth Ave. 39555 Orchard Hill Pl., Ste. 600 311 West Washington St. 1385 Burgundy 1150 Elijah McCoy Dr. 1180 E. Ellsworth Rd.

Shelby Township, 48108 734 945-8131 Ann Arbor, 48108 734 213-2123 Ann Arbor, 48105 734 930-5555 Sturgis, 49091 269 651-0787 Ada, 49335 616 787-6767 Ann Arbor, 48108 734 332-7800 Kalamazoo, 49008 269 372-3272 Lansing, 48910 517 336-4641 South Haven, 49090 269 637-8474 Ann Arbor, 48105 734 276-4921 Ann Arbor, 48103 734 527-9137 Mequon, WI, 53092 262 240-9961 Lexington, MA, 02421 617 538-5688 Ann Arbor, 48108 734 677-1774 Kalamazoo, 49007 269 349-8870 Detroit, 48202 313 872-6400 Ann Arbor, 48108 734 668-6113 Detroit, 48202 313 263-0960 Troy, 48083 248 526-3700 Kalamazoo, 49009 269 353-3805 Kalamazoo, 49007 269 381-4408 Mt. Pleasant, 48854 810 397-2882 Noblesville, IN, 46069 317 774-8069 Ann Arbor, 48108 734 663-4719 Detroit, 48201 313 442-8000 Dexter, 48130 734 426-3787 Ann Arbor, 48105 734 998-0751 Ann Arbor, 48105 734 913-9040 Grosse Pointe Farms, 48236 313 886-0589 Ferndale, 48220 866 424-6735 East Lansing, 48823 517 432-3044 Ann Arbor, 48104 734 994-5300 Novi, 48375 888 366-1496 Vicksburg, 49097 616 649-4200 Ann Arbor, 48105 734 995-0016 Detroit, 48202 313 871-8400 Ann Arbor, 48108 734 971-3335

3d-biomatrix.com aapharmasyn.com aastrom.com abbott.com accessbusinessgroup.com adeonapharma.com admetrx.com afidtherapeutics.com albemarle.com N/A N/A amgen.com aptuitconsulting.com ArborAssays.com armune.com ashstevens.com assaydesigns.com asterand.com auburnpharm.com aureogen.com aursos.com N/A bayerhealth.com handylab.com bd.com berryassoc.com Mycroarray.com bio-diagnostics.com N/A biopelle.com biopolymerinnovations.com liposol.com boropharm.com bridgeorganics.com N/A caraco.com caymanchem.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B iosciences continued Pharmaceuticals continued Cerenis Therapeutics Inc. 900 Victors Way, Ste. 280 Ann Arbor, 48108 734 769-1110 Cerise Nutraceuticals, Inc. 1670 Barlow St., Ste. A Traverse City, 49686 231 933-3300 CNVGenes LLC 4995 Arrowhead Rd. West Bloomfield, 48323 248 682-3368 Copagen 5528 Gallery Park Dr. Ann Arbor, 48103 734 904-0365 Corium International, Inc. 4558 50th St. Grand Rapids, 49512 616 656-4563 Detroit R & D, Inc. Metropolitan Center for High Technology, Detroit, 48201 313 961-1606

2727 Second Ave, Ste. 4113 DSC Labs 1979 Latimer Dr. Muskegon, 49442 231 777-3012 Ecology Health Products, Inc. 12941 E. Townline Rd. Goetzville, 49736 906 297-8770 Woodcliff Lake, NJ 07677 201 692-1100 Eisai, Inc. 100 Tice Blvd.

Eloquest Healthcare 780 West 8 Mile Rd. Ferndale, 48220 877 433-7626 Emergent BioSolutions 3500 Martin Luther King Jr. Blvd.

Lansing, 48906 517 327-1500 Emiliem 4717 Campus Dr., Ste. 700 Kalamazoo, 49009 415 421-0222 Esperion Therapeutics, Inc. 46701 Commerce Center Dr., Ste. B Plymouth, 48170 734 862-4840 exCel Cosmeceuticals, Inc. 4120 Maple Rd., Ste. 201 Bloomfield Hills, 48301 248 539-1212 EXT Lifesciences, Inc. 2000 Town Center, Ste. 2370 Southfield, 48075 248 948-6910 Ferndale Laboratories Inc. 780 West 8 Mile Rd. Ferndale, 48220 248 548-2422 Ferndale Pharma Group 780 West 8 Mile Rd. Ferndale, 48220 248 548-0900 Genentech 333 W. North Ave. Ste 399 Chicago, IL 60610 650 225-1000 Genetics Squared, Inc. 401 West Morgan Rd. Ann Arbor, 48108 734 929-9475 Giri Diagnostics LLC 2611 Parmenter Blvd.

Royal Oak, 48073 248 435-4472 Lewis Center, OH, 43035 740 549-2426 GlaxoSmithKline 7890 Charlie Ct. Global Strategic Connections, LLC 2125 Butterfield Dr., Ste. 218 Troy, 48084 248 816-6881 GlyTag LLC 32375 Lahser Rd. Beverly Hills, 48025 313 577-9827 Graminex, LLC 95 Midland Rd. Saginaw, 48638 877 472-6469 Grand River Aseptic Pharmaceutical Packaging, Inc. PO Box 3696 Grand Rapids, 49501 616 331-6980 Harvard Drug Company 31778 Enterprise Dr. Livonia, 48150 734 525-8700 HoMedics 3000 North Pontiac Trail Commerce Twp, 48390 248 863-3000 Horseshoe Herbals 1219 Anderson Rd. Niles, 49120 269 684-6888 Housey Pharmaceutical Research Laboratories, LLC 16800 W 12 Mile Rd., Ste. 201 Southfield, 48076 248 663-7000 Idea Sphere, Inc. 3133 Orchard Vista Dr SE Grand Rapids, 49546 616 464-5000 Innova Therapeutics 800 Technology Dr. Ann Arbor, 48108 734 222-9900 Innovative BioTherapies, Inc. 401 W. Morgan Rd. Ann Arbor, 48108 734 213-8350 Innovative Research Inc. 46430 Peary Ct. Novi, 48377 248 896-0145 International Diagnostics Systems Corp.

2620 S. Cleveland Ave., Ste. 100, PO Box 799 St. Joseph, 49085 269 428-8400 JB Laboratories 13295 Reflections Dr. Holland, 49424 616 738-8500 JHP Pharmaceuticals 870 Parkedale Rd. Rochester, 48307 248 656-5223 Jiva Pharma, Inc. 3995 Holden Dr. Ann Arbor, 48103 734 262-0673 Johnson & Johnson P.O. Box 726 Langhorne, PA 19047 N/A Kalexsyn, Inc. 4502 Campus Dr. Kalamazoo, 49008 269 488-8488 Komgen 3005 Whisperwood Dr., #288 Ann Arbor, 48105 734 272-5885 Lumigen, Inc. 22900 W. Eight Mile Rd. Southfield, 48033 248 351-5600 Luminos LLC 1514 Eisenhower Place Ann Arbor, 48108 734 677-1774 Lycera Corp.

46701 N. Commerce Center Dr., Ste. C Plymouth, 48170 734 233-3060 Major Pharmaceuticals 31778 Enterprise Dr. Livonia, 48150 734 427-2576 McKesson Pharmacy Systems 30881 Schoolcraft Livonia, 48150 734 779-8800 MedArray, Inc. 3915 Research Park Dr., Ste. A-4 Ann Arbor, 48108 734 769-1066 MedElute, Inc. 259 East Michigan Ave., Ste. 407 Kalamazoo, 49007 269 352-3760 Meditrina Pharmaceuticals, Inc. 300 North Fifth Ave., Ste. 150 Ann Arbor, 48104 734 926-0966 MERS, LLC 799 Skynob Dr. Ann Arbor, 48105 734 487-1251 Metabolic Solutions Development Co. 3133 Orchard Vista Dr. SE Grand Rapids, 49546 616 464-5071 Michigan Antibody Technology Center - Center 333 Bostwick Ave. Grand Rapids, 49503 616 234-5342 of Technology Excellence Michigan Diagnostics LLC 2611 Parmenter Blvd.

Royal Oak, 48073 248 435-4472 Michigan Technology and Research Institute, LLC 2245 South State St., Ste. 1100 Ann Arbor, 48104 734 222-0013 MitoStem 440 Burroughs Detroit, 48202 313 483-0385 Molecular Innovations Inc. 46430 Peary Ct. Novi, 48377 888 557-5055

cerenis.com cherrylotion.com cnvgenes.com N/A coriumintl.com detroitrandd.com dsclab.com ecologyproducts.com eisai.com eloquesthealthcare.com ebsi.com emiliem.com esperion.com xlafa.com extlifesciences.com ferndalelabs.com ferndalelabs.com gene.com genetics2.com giridiagnostics.com gsk.com gsc-llc.com glytag.com graminex.com GranDr.rAPP.com harvarddrugs.com homedics.com horseshoeherbals.com housey.com ideasphereinc.com N/A innbio.com innov-research.com ids-kits.com jblabs.com kingpharm.com N/A jnj.com kalexsyn.com N/A lumigen.com luminosassays.com lycera.com majorpharmaceuticals.com mckesson.com permselect.com N/A meditrinapharma.com mersllc.com msdrx.com ctaalliance.org/cta-cores/michiganantibody-technologies-core michdiag.com MTRInstitute.com N/A mol-innov.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B iosciences continued Pharmaceuticals continued MuciMed, Inc Mycol Balm Laboratories, Inc. NanoBio Corp.

Nanoderm Therapeutics, Inc. NanoVir LLC Natural Therapeutics, LLC Neocutis, Inc. Neogen Corp.

NephRx Corp.

Next Generation Therapeutics, Inc NextGen Sciences, Inc. Nitrate Elimination Company, Inc. Northern Biomedical Research, Inc Novartis Pharmaceuticals Corp.

Nymirum OncoImmune, Inc. Originus, Inc. OtoMedicine, Inc. Oxford Biomedical Research, Inc. Painex Corp.

Penn Pharmaceutical Services Perrigo Co. Pfizer Inc. PG Pharmaceuticals, Inc. Phadia US Phrixus Pharmaceuticals, Inc. Pointe Scientific, Inc. ProNAi Therapeutics, Inc. Proteos, Inc. Quality Care Products QuatRx Pharmaceuticals RealBio Technology, Inc. Rockwell Medical Technologies, Inc. Rubicon Genomics, Inc. sanofi-aventis US ScarPrev Pharmaceuticals SciTech Development Secretory IgA Inc. Sequenom Center for Molecular Medicine SoloHill Engineering, Inc. SPI Pharma SSV Therapeutics, LLC Sterling Diagnostics SubTerra LLC Surefill LLC Systems Specialties Takeda Pharmaceuticals North America, Inc. TCH Pharmaceuticals, Inc. Team Pharmaceutical Inc. Technology Partnership Therapeutics Systems Research Laboratories, Inc. Tolera Therapeutics, Inc. Tower Laboratories Montague Troy Biologicals, Inc. Urobiologics Velcura Therapeutics, Inc.

259 East Michigan Ave., Ste. 409 9595 Raucholz Rd. 2311 Green Rd., Ste. A 3081 N. Foxridge Ct. 4717 Campus Dr., Ste. 1300 401 W. Morgan Rd. 440 Burroughs 620 Lesher Pl. 4717 Campus Dr., Ste. 100 46701 Commerce Center Dr., Ste. A-6 4401 Varsity Dr., Ste. E 334 Hecla St. 930 W. Sherman Blvd.

One Health Plaza 117 N First St. 2900 N. Huron Pkwy., Ste. 2 3985 Research Park Dr., Ste. 200 330 East Liberty St., Lower Level 2165 Avon Industrial Dr. 18295 James Couzens Hwy. 10230 W. 50 N 515 Eastern Ave. 7000 Portage Rd. 2246 N. Monroe St. 4169 Commercial Ave. 300 N. Fifth Ave.,Ste. 150 5449 Research Dr. 4717 Campus Dr., Ste. 1100 4717 Campus Dr. 7560 Lewis Ave. 777 East Eisenhower Pkwy., Ste. 100 4717 Campus Dr., Ste. 1500 30142 Wixom Rd. 4355 Varsity Dr., Ste. E 55 Corporate Dr. 917 Packard St. 281 Kercheval 803 N. Main St. 301 Michigan St. NE, Ste. 580 4370 Varsity Dr., Ste. B PO Box 226 2245 South State St., Ste. 1100 36645 Metro Ct. P.O. Box 55, 104 Wilcox Rd. 4560 Danvers Dr. SE 390 Enterprise Ct., Ste. 200 One Takeda Pkwy.

300 N. Fifth Ave., Ste. 150 563 116th Ave. 8030 Coventry 540 Avis Dr., Ste. A 350 E. Michigan Ave., Ste. 205 8060 Whitbeck Rd. 1238 Rankin St. 31628 Glendale Ave. 4300 Varsity Dr., Ste. D

Kalamazoo, 49007 906 842-3212 St. Charles, 48655 989 585-3357 Ann Arbor, 48105 734 302-4000 Ann Arbor, 48105 734 665-4105 Kalamazoo, 49008 269 372-3261 Ann Arbor, 48108 734 302-3200 Detroit, 48202 734 207-5104 Lansing, 48912 800 234-5333 Kalamazoo, 49008 317 979-2483 Plymouth, 48170 734 527-9139 Ann Arbor, 48108 734 973-7914 Lake Linden, 49945 906 296-1000 Muskegon, 49441 231 759-2333 East Hanover, NJ 07936 N/A Ann Arbor, 48105 734 604-9597 Ann Arbor, 48105 734 994-8454 Ann Arbor, 48108 734 913-8791 Ann Arbor, 48104 269 615-0668 Rochester Hills, 48309 248 852-8815 Detroit, 48235 313 863-1200 Columbus, IN 48201 812 342-3528 Allegan, 49010 269 673-8451 Kalamazoo, 49001 269 833-4000 Monroe, 48162 248 632-1666 Portage, 49002 800 346-4364 Ann Arbor, 48104 734 358-9015 Canton, 48188 800 445-9853 Kalamazoo, 49008 269 372-3289 Kalamazoo, 49008 269 372-3423 Temperance, 48182 734 847-3847 Ann Arbor, 48108 734 913-9900 Kalamazoo, 49008 269 544-1088 Wixom, 48393 800 449-3353 Ann Arbor, 48108 734 677-6210 Bridgewater, NJ, 08807 636 273-5409 Ann Arbor, 48104 734 717-9263 Grosse Pointe Farms, 48236 313 576-8263 Ann Arbor, 48104 734 994-0966 Grand Rapids, 49503 616 391-4330 Ann Arbor, 48108 734 973-2956 Grand Haven, 49417 231 935-6900 Ann Arbor, 48104 734 262-0673 Sterling Heights, 48312 586 979-2141 White Pine, 49971 906 885-5953 Grand Rapids, 49512 616 532-1700 Bloomfield Hills, 48302 248 332-0099 Deerfield, IL, 60015 715 246-9930 Ann Arbor, 48104 734 926-0966 Martin, 49070 269 388-5708 Grosse Ile, 48138 313 675-8295 Ann Arbor, 48108 734 663-4233 Kalamazoo, 49007 269 585-2100 Montague, 49437 231 893-1472 Troy, 48083 800 521-0445 Livonia, 48150 313 574-7500 Ann Arbor, 48108 734 973-1000

N/A mycolbalm.com nanobio.com N/A nanovirpharm.com fungalnailrelief.com neocutis.com neogen.com nephrx.com nextgenerationtherapeutics.com nextgensciences.com nitrate.com N/A novartis.com nymirum.com oncoimmune.com originusinc.com otomedicine.com oxfordbiomed.com ringmasternow.com pennpharm.com perrigo.com pfizer.com pg-pharma.com phadia.us phrixuspharmaceuticals.com pointescientific.com pronai.com proteos.net qcpmeds.com quatrx.com realbiotechnology.com rockwellmed.com rubicongenomics.com sanofi-aventis.us N/A scitechdevelopment.com secretoryiga.com cmmdx.org solohill.com spipharma.com ssvtherapeutics.com sterlingdiagnostics.com subterrallc.com surefill.com sysspec.com tpna.com N/A N/A N/A tsrlinc.com tolera.com towerlabs.com troybio.com urobiologics.com velcura.com

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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B iosciences continued Pharmaceuticals continued Velesco Pharmaceutical Services Vertellus Health and Specialty Products, LLC Vortech Pharmaceuticals W.F. Valentine & Co. WelchDry Working Bugs, LLC zuSyn

46701 N. Commerce Center Dr. 215 North Centennial St. 6851 Chase Rd. 7633 Quackenbush 4270 Sunnyside Dr. 16647 Chandler Rd. 4717 Campus Dr., Ste. 100

Plymouth, 48170 Zeeland, 49464 Dearborn, 48126 Reading, 49274 Holland, 49424 East Lansing, 48823 Kalamazoo, 49008

734 545-0696 800 223-0453 313 584-4088 517 283-3143 616 399-2711 517 203-4744 312 997-2150

velescopharma.com vertellus.com vortechpharm.com horseshoes.com welchdry.com workingbugs.com zusyn.com

5575 Conner Ave, Ste. 1G 3655 Forest Rd. 5692 Plymouth Rd., Ste. B 24469 Indoplex Circle 812 Avis Dr. 800 Technology Dr. 39 Blackburn SW 225 Parsons St. 3025 Boardwalk St., Ste. 200 120 Enterprise Dr. 30055 Northwestern Highway, Ste. 101 2245 South State St., Ste. 1100 37428 Hills Tech Dr. 800 Technology Dr. 620 Lesher Place 2925 Bond 54943 N. Main St. 12649 Richfield Ct. 4169 Commercial Ave. 28221 Beck Rd., Ste. A-11 4444 Giddings Rd. 175 College St 32355 Capitol St. 4669 Executive Dr. 301 Michigan St. NE, Ste. 580 6320 Van Dyke Rd. 1159 E. Michigan Ave. 3728 Plaza Drive, Ste. 1 300 W. Textile Rd. 1197 Rochester Road, Ste. K

Detroit, 48213 Lansing, 48910 Ann Arbor, 48105 Farmington Hills, 48335 Ann Arbor, 48108 Ann Arbor, 48108 Wyoming, 49509 Kalamazoo, 49007 Ann Arbor, 48108 Ann Arbor, 48103 Farmington Hills, 48336 Ann Arbor, 48104 Farmington Hills, 48331 Ann Arbor, 48108 Lansing, 48912 Rochester Hills, 48309 Mattawan, 49071 Livonia, 48150 Portage, 49002 Wixom, 48393 Auburn Hills, 48326 Battle Creek, 49037 Livonia, 48150 Portage, 49002 Grand Rapids, 49503 Cass City, 48726 Ypsilanti, 48198 Ann Arbor, 48108 Ann Arbor, 48108 Troy, 48083

313 921-2266 800 631-3510 734 913-9040 248 426-9800 866 856-4404 734 945-9077 616 828-2207 269 492-7700 734 205-1231 734 426-3003 248 865-4444 734 222-0013 248 324-4800 734 821-1063 800 234-5333 248 257-0000 269 250-2177 734 462-3900 800 346-4364 248 348-7029 248 373-9120 269 969-6161 734 525-0248 269 324-7383 616 391-4330 989 872-8070 734 528-0657 734 669-8440 734 214-0300 248 307-1168

accessdiagnostics.net antelbio.com bio-diagnostics.com biotechclinical.com biotronic.com cuttingimagehistology.com N/A Forensicfluids.com inviasolutions.com mobileleasing.com michiganear.com MTRInstitute.com microbioassociates.com molecularimaging.com neogen.com oaklandgenetics.com Ophthy-DS.com paragonlaboratories.com phadia.us quantumlaboratories.com questdiagnostics.com rml-lab.com N/A sandjlab.com cmmdx.org thumbmri.com uimedical.com vetgen.com wardelab.com westernslopelabs.com

350 E. Michigan Ave., Ste. 500 Market Place Bldg., 303 Detroit St., Ste. 301 1328 Ramblewood 125 S. Fifth Ave., PO Box 8009 3601 W. 13 Mile Rd. 803 N. Main St. 35735 Mound Rd. 350 S. Main St., Ste. 300 3600 Green Ct., Ste. 400 29 Crafts St., Ste. 270 5440 Corporate Dr., Ste. 300, PO Box 7078 8649 Bonaventure 5005-4 N. Lincoln Ave. 55 E. Long Lake Rd., PMB #433 755 West Big Beaver, Ste. 2300

Kalamazoo, 49007 Ann Arbor, 48104 East Lansing, 48823 Ann Arbor, 48104 Royal Oak, 48073 Ann Arbor, 48104 Sterling Heights, 48311 Ann Arbor, 48104 Ann Arbor, 48105 Newton, MA, 02458 Troy, 48007 Brighton, 48116 Chicago, IL, 60625 Troy, 48085 Troy, 48084

269 349-8999 734 998-3688 517 316-2138 734 662-1600 248 551-3010 734 930-9741 586 977-6300 734 213-3435 919 240-4089 617 630-8100 734 741-1850 810 231-1231 773 818-8210 248 232-8894 248 244-3005

apjohngroup.com arboretumvc.com autosofttech.net boaa.com beaumontservices.com bioconsultants.com bbdetroit.com butzel.com pipetpeople.com capitaladvisors.com chubb.com consumerbg.com cvct.biz detroit-tech.com doeren.com

Testing Access Diagnostics, Inc. Antel BioSystems, Inc. Biomedical Diagnostics, LLC Biotech Clinical Laboratories Biotronic Neural Monitoring Specialists Cutting Image Histology, LLC DRAMgene Forensic Fluids Laboratories Inc. INVIA Medical Imaging Solutions Medical Imaging Resources, Inc. Michigan Ear Institute Michigan Technology and Research Institute, LLC Microbiological Associates, Inc. MIR Preclinical Services (Molecular Imaging Research) Neogen Corp.

Oakland Genetics LLC Ophthy-DS, Inc Paragon Laboratories, Inc. Phadia US Quantum Laboratories Quest Diagnostics Inc. Regional Medical Lab, Inc. Roche Biomedical Labs S & J Laboratories Sequenom Center for Molecular Medicine Thumb MRI Center, LLC Universal Imaging VetGen, LLC Warde Medical Laboratory Western Slope Laboratory

P R O F E S S I O N A L S E RV I C E S Apjohn Group, LLC Arboretum Ventures Automated Software Technology Bank of Ann Arbor Beaumont Services Company LLC Biotechnology Business Consultants & BBCetc.

Brown & Brown of Detroit Butzel Long Calibrate, Inc. Capital Advisors Group Chubb Group of Insurance Co. Consumer Benefits Group LLC CVCT, Inc. Detroit Technical Equipment Co. Doeren Mayhew

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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P R O F E S S I O N A L S E RV I C E S continued Drug & Laboratory Disposal, Inc. Dykema Gossett PLLC Elsevier Ernst & Young LLP e-Zassi Farnell Equipment Co. Fulcrum Pharma Developments, Inc. Fullscope, Inc. GCPM Gifford, Krass, Sprinkle, Anderson & Citkowski, PC Grant Thornton LLP Great Lakes Angels, Inc. Harness, Dickey & Pierce, P.L.C. Honigman Miller Schwartz and Cohn LLP Hylant Group Innovative Analytics Intertek Kestrel Consultants, Inc. Law Offices of Gary Kendra, PC Linde Gas Mangosoft Marketwire Miller, Canfield, Paddock and Stone, PLC Monitor Liability Mangers Inc. Nature Publishing Group Office Depot O’Mara Scientific Performance Validation LLC Pharmacision LLC PharmaMed Resources, LLC PharmMor Consulting, LLC Plex Systems Praxis Bio Consulting, LLC Price, Heneveld, Cooper, DeWitt & Litton Product Center for Agriculture and Natural Resources, Michigan State University ProPharma Group ProReg Resources, LLC Quality Air Service, Inc. Rader, Fishman & Grauer PLLC Safis Solutions LLC Science Direct Single Source Procurement, LLC Skyline Property Group, Inc. Smith Haughey Rice & Roegge Switchback Tech Depot Teresa M. Arnold & Assoc.

The Point Services The Project Group Trialon Corp.

Trossen HR Group Validation & Compliance Institute, LLC Varnum, Riddering, Schmidt & Howlett VWR International Warner Norcross & Judd LLP

331 Broad St. 400 Renaissance Center 3675 Crestwood Pkwy.

171 Monroe Ave. NW, Ste. 1000 1886 S. 14th St. 2950 Todd Dr. 900 Victors Way, Ste. 160 1399 Rand Rd. 405 Edgemoor Ave. PO Box 7021 27777 Franklin Rd, Ste. 800 568 Woodway Ct., Ste. 1 5445 Corporate Dr., Ste. 200 350 E. Michigan Ave., Ste. 300 24 Frank Lloyd Wright Dr., Ste. J4100 161 E Michigan, Haymarket 5th 4700 Broadmoor, Ste. 200 410 Rose Dr. 143 Cady Centre, #319 2100 Western Ct., Ste. 100 29A Riverside St. 200 W. Adams St., Ste. 2725 840 W. Long Lake Rd., Ste 200 2850 W. Golf Rd., Ste. 800 5 Varick St., 9th Fl. 800 Eisenhower Pkwy 3025 Sangra Ave. 5148 Lovers Ln., Ste. 200 1947 Mistwood Ct. 790 Crosswind Ln. PO Box 2570 1731 Harmon Rd. 2720 Aspen Ridge 695 Kenmoor SE 80 Agriculture Hall

Plainwell, 49080 269 685-9824 Detroit, 48243 313 568-6800 Duluth, GA, 30096 678 344-8219 Grand Rapids, 49503 313 628-7100 Amelia Island, FL, 32034 904 261-6290 Troy, 48084 248 643-8890 Ann Arbor, 48108 734 994-7394 Canton, 48187 734 667-1204 Kalamazoo, 49001 N/A Troy, 48007 248 647-6000 Southfield, 48034 N/A Bloomfield Hills, 48302 248 540-3758 Troy, 48098 248 641-1600 Kalamazoo, 49007 269 337-7700 Ann Arbor, 48105 734 741-0044 Kalamazoo, 49007 269 488-3200 Kentwood, 49512 616 656-0601 Ann Arbor, 48103 734 576-3031 Northville, 48167 248 596-1879 Lisle, IL, 60532 734 424-1327 Nashua, NH, 03062 888 886-2646 Chicago, IL, 60606 312 261-4212 Troy, 48098 313 963-6420 Rolling Meadows, IL, 60008 N/A New York, NY, 10013 212 726-9760 Ann Arbor, 48106 734 259-9281 Grandville, 49418 616 531-9500 Portage, 49024 269 373-9112 Canton, 48187 734 895-3670 Lindenhurst, IL, 60046 269 303-0798 Portage, 49081 269 327-2215 Auburn Hills, 48326 248 391-8000 Ann Arbor, 48103 734 585-5296 Grand Rapids, 49501 616 949-9610 East Lansing, 48824 517 432-1676

dld-inc.com dykema.com elsevier.com ey.com ezassi.com farnell-equipment.com fulcrumpharma.com fullscope.com gettsconsulting.com patlaw.com gt.com glangels.org hdp.com honigman.com hylant.com ianalytis.biz intertek.com kestrelconsultants.com kendralaw.com lindeus.com mangosoft.com marketwire.com millercanfield.com monitorliability.com nature.com officedepot.com omarascientific.com perfval.com pharmacision.com pharmamedresources.com N/A plex.com praxisbio.com priceheneveld.com productcenter.msu.edu

8175 Creekside Dr. 8889 2nd St. 6701 Quality Way 39533 Woodward Ave., Ste. 140 342 Massachusetts Ave., Ste. 402 3675 Crestwood Pkwy., Ste. 400 4717 Campus Dr. 2146 Livernois 213 S. Ashley, Ste. 400 300 N. Fifth, Ste. 120 N/A 8300 Adler Rd. 1515 Chimney Ridge 7238 Windhaven Ct. 5600 New King St., Ste. 345 58 Parkland Plaza, Suite 200 1529 Boxford Rd. Bridgewater Pl, 333 Bridge St. NW 1668 Chapleau Dr. 900 Fifth Third Center, 111 Lyon St NW

Portage, 49024 Mattawan, 49071 Portage, 49002 Bloomfield Hills, 48304 Indianapolis, IN, 46204 Duluth, GA, 30096 Kalamazoo, 49008 Troy, 48083 Ann Arbor, 48104 Ann Arbor, 48104 N/A Lambertville, 48144 Traverse City, 49686 Portage, 49024 Troy, 48098 Ann Arbor, 48103 Dearborn, 48183 Grand Rapids, 49501 Ann Arbor, 48103 Grand Rapids, 49503

propharmagroup.com proregresources.com qairservice.com raderfishman.com safis-solutions.com elsevier.com sspusa.com N/A shrr.com switchbackcms.com bio.techdepot.com tmaapr.com thepointservcies.com N/A trialon.com trossenhr.com vcillc.com varnumlaw.com vwr.com wnj.com

888 242-0559 269 372-2911 269 327-3055 248 594-0600 317 777-6200 770 935-6077 269 372-3997 248 680-9900 734 213-8000 734 418-8348 313 263-0960 734 854-1187 231 366-4121 269 321-0411 248 641-1032 734 904-5611 734 274-4680 616 336-6000 800 932-5000 616 752-2169

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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M anu facturing S uppliers Arrow Electronics Divtech Equipment Co. Landaal Packaging Systems Midwest Cleanroom Associates, Inc. PTI Engineered Plastics, Inc. SMG Cleanroom Technologies Staubli Corporation

44760 Helm St. PO Box. 58468 3256 B. Iron St. 2055 Oak Industrial Dr., Ste A 50900 Corporate Dr. 2685-G Northridge Dr. 44467 Charnwood Dr.

Plymouth, 48170 Cincinnati, OH 45258 Burton, 48529 Grand Rapids, 49505 Clinton Twp, 48044 Grand Rapids, 49544 Plymouth, 48170

937-428-7300 513-941-0483 810 223-0605 616 458-8533 586 263-5100 616-785-3330 734 417-4970

arrow.com divtechequipment.com landaal.com mcacleanrooms.com teampti.com smgcleanrooms.com/ staubli.us.com

8205 Huron River Dr. 23815 Northwestern Hwy. 30300 Telegraph Rd., Ste 117 201 S. Division, Ste. 430 2675 Bellingham 4717 Parkview Campus Dr. 323 W. Michigan 2203 Platt Rd. 3260 Homestead Ct. 3520 Green Ct. 24359 Northwestern Hwy., #225 828 W. Grand River Ave.

Dexter Twp., 48130 Southfield, 48075 Bingham Farms, 48025 Ann Arbor, 48104 Troy, 48083 Kalamazoo, 49008 Marshall, 49068 Ann Arbor, 48104 Saline, 48176 Ann Arbor, 48105 Southfield, 48075 Brighton, 48116

734 845-3661 248 355-4500 248 433-3830 734 761-9317 248 457-3200 269 544-1072 269 781-5183 800 482-4881 734 429-4961 734 647-8951 248 355-1133 810 494-7193

mi-asm.org aseonline.org diabetes.org AnnArborUSA.org automationalley.com brcc.wmich.edu cityofmarshall.com giftoflifemichigan.org goteborgbio.se gleq.org jdrfdetroit.org cmod.org

1200 Pontiac Lake Rd., Bldg 41W

Waterford, 48328

248 858-9099

medicalmainst.org

1501 N. Shore Dr., Ste. A 327 Seymour Ave. 326 W. Ottawa, Capitol Corners 27177 Lahser Rd., Ste. 102

East Lansing, 48823 Lansing, 48933 Lansing, 48933 Southfield, 48034

517 332-8663 517 371-3181 517 372-8898 248 948-5555

miagbiz.org mahp.org michiganchemistry.com stemcellresearchformichigan.com

12800 Escanaba Dr., Ste. B

Dewitt, 48820

517 323-6600

micorn.org

300 North Washington Square 6215 W. St. Joseph Hwy. 2410 Woodlake Dr., PO Box 30014 3520 Green Ct., Ste. 450 46701 Commerce Center Dr. 325 W. Lake Lansing Rd., Ste. C 1910 W. St. Andrews Rd. 2310 Jolly Oak Rd. 2445 Woodlake Circle 7215 Westshire Dr. 401 W. Morgan Rd. 3300 Washtenaw Ave., Ste. 220 Grand Valley State Univ., 510 W. Fulton St.

Lansing, 48913 Lansing, 48917 Okemos, 48864 Ann Arbor, 48105 Plymouth, 48170 East Lansing, 48823 Midland, 48640 Okemos, 48864 Okemos, 48864 Lansing, 48917 Ann Arbor, 48108 Ann Arbor, 48104 Grand Rapids, 49504

517 373-9808 517 323-3443 517 347-3332 734 604-2479 N/A 517 332-8663 989 832-5550 517 349-5818 517 347-1555 517 381-8000 734 302-3200 734 973-0433 616 331-7480

michiganadvantage.org mha.org mhc.org michiganisrael.com mlsic.com smilemichigan.com mmi.org minurses.org mi-osteopathic.org mpca.net msta-mich.org misbtdc.org

140 W. Tuscola St., PO Box 287 120 W. Saginaw 425 N. Main St. 4520 E. Ashman Rd., Ste. M 3025 Boardwalk 1169 Oak Valley Dr. 950 F St., NW, Ste. 300

Frankenmuth, 48734 East Lansing, 48826 Ann Arbor, 48104 Midland, 48642 Ann Arbor, 48108 Ann Arbor, 48108 Washington, DC, 20004

989 652-3294 517 337-1651 734 223-3750 989 839-2333 800 222-6267 734 222-9800 202 835-3400

michigansoybean.org msms.org michiganvca.org mmic.us ncms.org nkfm.org phrma.org

241 East Michigan Ave. 4717 Campus Dr., Ste. 100 161 Ottawa Ave. NW, Ste. 400 440 Burroughs 301 Michigan St. NE, Ste. 537 Grand Valley State Univ.

Kalamazoo, 49024 Kalamazoo, 49008 Grand Rapids, 49503 Detroit, 48202 Grand Rapids, 49503

269 553-9588 269 353-1823 616 771-0325 313 879-5250 616 331-5840

southwestmichiganfirst.com kazoosmic.com rightplace.org techtownwsu.org/ wmsti.org

G o v e rnm e nt / N on - P rofit American Society for Microbiology American Society of Employers American Diabetes Assoc.

Ann Arbor SPARK Automation Alley Biosciences Research & Commercialization Ctr. City of Marshall Economic Development Gift of Life Michigan GÜteborgBio - BRG Great Lakes Entrepreneur’s Quest Juvenile Diabetes Research Fdn. International Partnership for Critical Markers of Disease (CMOD) Medical Main St.-Oakland County Planning & Economic Development Michigan Agri-Business Assoc.

Michigan Association of Health Plans Michigan Chemistry Council Michigan Citizens for Stem Cell Research and Cures (MCSCRC) Michigan Corn Growers Assoc./Corn Marketing Program of Michigan Michigan Economic Development Corporation Michigan Health & Hospital Assoc.

Michigan Health Council Michigan Israel Business Bridge Michigan Life Science and Innovation Ctr. (MLSIC) Michigan Medical Dental Assoc.

Michigan Molecular Institute Michigan Nurses Assoc.

Michigan Osteopathic Assoc.

Michigan Primary Care Assoc.

Michigan Research Institute Michigan Science Teachers Assoc.

Michigan Small Business & Technology Development Center Michigan Soybean Promotion Committee Michigan State Medical Society Michigan Venture Capital Assoc.

MidMichigan Innovation Ctr. National Center for Manufacturing Sciences National Kidney Foundation of Michigan PhRMA (Pharmaceutical Research and Manufacturers of America) Southwest Michigan First Southwest Michigan Innovation Center The Right Place, Inc. TechTown West Michigan Science and Technology Initiative

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

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E ducation / C linical American Society of Employers 23815 Northwestern Hwy. Beaumont Hospitals 3601 W. Thirteen Mile Rd. Borgess Research Institute 1521 Gull Rd. Field Neuroscience Institute 4677 Towne Centre Rd., Ste. 101 Grand Valley State University 301 Michigan St. NE, Cook-DeVos Center

for Health Sciences, Ste. 554 Henry Ford Hospital 2799 W. Grand Blvd.

Karmanos Cancer Institute 4100 John R. Michigan Nanotechnology Institute 1150 W. Medical Center Dr., for Medicine & Biological Sciences, U-M SPC 5648, 9220C MSRB III Michigan State University Office of 120 W. Saginaw Research & Graduate Studies Michigan State University Institute for D 132 W. Fee Hall HealthCare Studies Michigan State University, MSU Technologies 301 Administration Bldg.

Michigan Technological University Office of 1400 Townsend Dr.Advanced Technology Technology and Economic Development Development Complex Michigan Universities Commercialization Initiative (MUCI) 3003 South State St., Wolverine Tower, Rm, 1006 Oakland Community College - Orchard Ridge Campus 27055 Orchard Lake Rd., C-101 Oakland University 520 Dowd Hall Robertson Research Institute 4215 Fashion Square Blvd.

The MRI Institute for Biomedical Research Imaging 440 East Ferry St., Unit 2 U-M Biomedical Engineering 2200 Bonisteel Blvd.

U-M Center for Oral Health 1011 North University, Rm. 3228 U-M Life Sciences Institute 210 Washtenaw Ave. U-M Medical Innovation Ctr. 24 Frank Lloyd Wright Dr., Lobby M, Ste. 2600 U-M Michigan Institute for Clinical Health Research 24 Frank Lloyd Wright Dr., Lobby M U-M Office of Vice President for Research 4080 Fleming Bldg., 503 Thompson U-M Technology Transfer Office 1214 S. University Van Andel Institute 333 Bostwick Ave. NE Wayne State University - Technology Commercialization 440 Burroughs, Ste. 201 Western Michigan University 1903 W. Michigan Ave.

Southfield, 48075 Royal Oak, 48073 Kalamazoo, 49048 Saginaw, 48604 Grand Rapids, 49503

248 223-8019 248 551-8550 269 226-5407 989 497-3117 616 331-8643

aseonline.org beaumonthospitals.com research.borgess.com fni.org gvsu.edu

Detroit, 48202 Detroit, 48201 Ann Arbor, 48109

313 916-2024 313 576-8931 734 647-2777

henryford.com karmanos.org nano.med.umich.edu

East Lansing, 48826

517 377-1651

vprgs.msu.edu

East Lansing, 48824

517 432-4325

ihcs.msu.edu

East Lansing, 48824 Houghton, 49931

517 355-5040 906 487-2228

cga.msu.edu mtu.edu

Ann Arbor, 48109 Farmington Hills, 48334 Rochester, 48309 Saginaw, 48603 Detroit, 48202 Ann Arbor, 48109 Ann Arbor, 48109 Ann Arbor, 48109 Ann Arbor, 48106 Ann Arbor, 48106 Ann Arbor, 48109 Ann Arbor, 48104 Grand Rapids, 49503 Detroit, 48202 Kalamazoo, 49008

734 647-5730 248 522-3741 248 370-2100 989 799-8720 313 758-0065 734 764-9588 734 647-4622 734 763-1200 734 998-6994 734 998-7474 734 764-1185 734 763-0614 616 234-5000 313 577-5541 269 387-1000

muci.org oaklandcc.edu/MolecularBiotechnology/ oakland.edu robertsoninstitute.org mrimaging.com bme.umich.edu dent.umich.edu/research/clinicalresearch lsi.umich.edu med.umich.edu/ummic michr.umich.edu research.umich.edu techtransfer.umich.edu vai.org techtransfer.wayne.edu wmich.edu

MichBio Member Annual Corporate Sponsor Preferred Provider For the most current list of companies, please visit the MichBio website at www.michbio.org.

67

BioMatters | Spring 2010

The Pharmaceutical Research and Manufacturers of America

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IN MICHIGAN, SOMETHING NEW IN HIGH-TECH INNOVATION IS HAPPENING EVERY DAY. Working with our partners at MichBio, the Michigan Economic Development Corporation can connect high-tech companies and entrepreneurs to services, incentives, networking opportunities and venture capital to help them grow and prosper.

SM

Visit MichiganAdvantage.org and learn how Michigan can give your biotech company the Upper Hand.Â

MichiganAdvantage.org

Get Connected.

Nurturing an idea into a marketable product and growing it into a dynamic, self-sustaining bioscience company is a process. How do Michigan companies connect with the right people, learn what they need to know, find the resources to keep the pipeline flowing?

MichBio brings the total continuum together. We know the players, the market; and what it takes. We give you access to a valuable network of people representing all facets of the biosciences community. We are your matchmaker, your guru and your standard bearer.

In a state boasting the world’s longest freshwater coastline, with oceans of lakes, where water is a way of life and life is good; in an industry that studies life at its core, MichBio is there to propel Michigan’s bioscience people, products and prospects.

Join us.

Ann Arbor, MichigAn

734.527.9150

www.Michbio.org