BioMatters - Spring 2011

BioMatters S P R I N G 2 011

A MichBio Publication Showcasing Michigan’s Biosciences Industry

A New Governor Brings

VC Experience and Vision for Michigan BioCompanies In This Issue: 2011 Michigan Biosciences Directory and Resource Guide Also Featured: From Mind to Market: The Network of Support for Michigan Entrepreneurs Profiles of Michigan Companies Traveling Down the Commercialization Highway Michigan Boasts a Wealth of High-Tech Talent and a Workforce Pipeline to Match

GOVERNOR’S MESSAGE

Dear Friends,

Each and every day, people depend on the products of Michigan entrepreneurs in countless

aspects of daily life. We are the state that moved the world into a new industrial age and built America’s middle class. We take great pride in our past successes and people — like Herbert Dow, Henry Ford, W.K. Kellogg, and Dr. William Upjohn — who made history from right here in Michigan.

Today people like you are moving Michigan into a new era of innovation.

All across Michigan the bioscience sector is creating a new backdrop for our economy.

Our world class colleges and universities have partnered with public and private sector leaders to make Michigan the home of one of America’s strongest and fastest growing biosciences sectors.

From 2005 to 2009, nearly a half billion dollars was invested in our biosciences sector, and

we continue to attract venture capital and see more and more startup companies. Moreover, our state’s quality of life, rich natural resources and distinctive charm make Michigan a great place to work and raise a family. We are committed to keeping the Great Lakes State a place that transforms creativity into opportunity.

Sincerely,

Rick Snyder, Governor of Michigan

Ideal incubator space for life sciences or high-technology companies.

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Our incubators offer:

For more information contact: Rich Cook, Venture Center Director

• Standard lab amenities and options for customization • Mini labs of ten lineal feet of bench space with cabinetry • Locations ranging from 300 to 1,500 square feet • Access to analytical instrumentation and engineering tools, including a thermogravimetric analyzer (TGA), differential scanning calorimeter (DSC), fume hood and bio-safety cabinet

West Michigan Science & Technology Initiative Cook-DeVos Center for Health Sciences Grand Valley State University P: 616.331.5840 | wmsti@gvsu.edu | www.wmsti.org

• Affordable rates • Office and meeting space available

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BioMatters | Spring 2011

Innovate. Accelerate.

Wherever you are in the world, wherever you are in the R&D process, Michigan bioscience companies and organizations have the expertise, technologies, development understanding, and talent to support your endeavor.

Visit us in the Michigan Pavilion #1337 at the 2011 BIO International Convention. Chat with representatives of the following companies, just a sampling of what we have to offer‌it’s Pure Michigan.

Clinical Trials

Grand River Aseptic Mfg. (Grand Rapids) A pharmaceutical contract manufacturing

Barbara Ann Karmanos Cancer Center (Detroit) Designated by the National Cancer

organization (CMO) primarily supporting early stage clinical trials (Phase I and II).

Institute as one of only 13 Centers of Excellence in oncology in the U.S., and the only

www.grandriverasepticmfg.com

Michigan hospital focusing solely on cancer. www.karmanos.org

JHP Pharmaceuticals (Rochester) Manufactures and sells brand aseptic injectable

ClinXus (Grand Rapids) A nonprofit, life sciences alliance, dedicated to benefiting

pharmaceuticals in hospital/clinical settings, and provides contract manufacturing

human health through participation in innovative, early phase biomarker and

services for global pharmaceutical companies. www.jhppharma.com

molecular-based trials. www.clinxus.com

Kalexsyn (Kalamazoo) Expert medicinal chemistry services, including synthetic

Detroit Clinical Research Center (Detroit) A health research institution that supports

design SAR and general drug development consulting, medicinal chemistry synthesis,

clinical studies at and collaborates with hospitals and medical facilities in Michigan,

parallel and combinatorial synthesis, process improvement/development, stable label

North America and internationally. www.dcrc.us

compound. www.kalexsyn.com

Jasper Clinical Research and Development (Kalamazoo) An independent phase I

Medigenix LLC (Novi) Offers preclinical testing, hybridoma core services and

clinical pharmacology service provider specializing in innovative early clinical

mouse surgical models at a state-of-the-art microsurgery suite and vivarium.

research studies. www.jasperclinic.com

www.medigenix.com

Michigan Institute for Clinical & Health Research (Ann Arbor) Enables

MPI Research (Mattawan) The world’s third-largest organization offering nonclinical

and enhances clinical and translational research by integrating education, career

and early clinical research and development services for the pharmaceutical biotech-

development, infrastructure, and support to catalyze research in the laboratory, clinic,

nology, medical device and animal health industries. www.mpiresearch.com

and community. www.michr.umich.edu

MPR Development Group (Farmington Hills) A full-service global clinical research and development organization that assists pharmaceutical and biotechnology

Contract Research Organizations

companies to bring new therapies to patients efficiently. www.mpr.com

Ascendant MDx Laboratory Sciences (Farmington Hills) A new kind of clinical lab for diagnostic tests focused on making the laboratory services experience easier for

VPCI-Inc. (West Bloomfield) Advanced consulting services, including worldwide

patients and healthcare providers. http://ascendantmdx.com

regulatory, manufacturing and business development for the pharmaceutical and

Ash Stevens (Detroit) A world leader in the development, manufacture and registration

biotech industries. http://vpcint.com/index.html

of small molecule APIs. www.ashstevens.com

Research & Development

Bryllan LLC (Farmington Hills) Contract manufacturing services to the global

Cerenis Therapeutics (Ann Arbor) A pharmaceutical company focused on the

biotechnology and pharmaceutical industry with a focus on potent and cytotoxic

discovery, development and commercialization of breakthrough HDL-related therapies

compounds in novel delivery mechanisms. www.bryllan.com

for the treatment of cardiovascular and metabolic diseases. www.cerenis.com

BioMatters | Spring 2011

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Michigan.

Compendia Bioscience (Ann Arbor) Dedicated to applying the global collection

TechTown (Detroit) The place where state-of-the-art work space, business support

of cancer genomic data to enable the discovery and development of better cancer

and community development come together. www.techtownwsu.org

diagnostics and treatments. www.compendiabio.com

University Research Corridor (Lansing) An alliance of Michigan’s three leading

Esperion Therapeutics (Plymouth) Discovers and develops therapies to prevent,

research institutions: Michigan State University, the University of Michigan and Wayne

treat, and reverse cardiovascular and metabolic diseases. www.esperion.com

State University. www.urcmich.org

Everist Genomics (Ann Arbor) An emerging biotechnology company focused on

Van Andel Institute (Grand Rapids) Committed to improving health and

delivering the promise of personalized medicine. www.genetics2.com

enhancing lives through disease research and science education. A primary focus

GeneCodes (Ann Arbor) An international software firm specializing in bioinformatics software for DNA sequence analysis. www.genecodes.com Innovative Research (Novi) Supplies researchers with dependable human and animal biological, coagulation proteins, antibodies and EUSA kits. www.innov-research.com Lumigen, Inc., (Southfield) (a Beckman Coulter Company) is an ISO 9001:2008

on cancer research, but studies on diseases such as osteoporosis, Parkinson disease, and diabetes as well. www.vai.org

Local Partners Ann Arbor SPARK (Ann Arbor) The driving force in establishing the Ann Arbor region as a desired place for business expansion and location by identifying and meeting the needs of business at every stage. www.AnnArborUSA.org

Registered Corporation, and is one of the world’s largest suppliers of chemiluminescent

Southwest Michigan First (Kalamazoo) The catalyst stimulating growth across the

reagents to the clinical immunodiagnostics market. www.lumigen.com

Kalamazoo Region. www.southwestmichiganfirst.com

RealBio Technology (Kalamazoo) Commercializing leading-edge cell and tissue

The Right Place (Grand Rapids) Develops and implements comprehensive

culture technology that supports the growth, expansion, differentiation and collection

strategies to retain, expand and attract businesses vital to the west Michigan region’s

of human and non-human tissues and cells. www.realbiotechnology.com

long-term health. www.rightplace.org

TSRL (Ann Arbor) An oral drug delivery specialty firm. www.tsrlinc.com

Wayne County (Detroit) Offers a first-class business environment, a top-rated

Tech Transfer/Commercialization Oakland University Center for Biomedical Research (Rochester Hills) Promotes and supports biomedical research and education at Oakland University and allied institutions. www2.oakland.edu/cbr Southwest Michigan Innovation Center (Kalamazoo) A 69,000 square-foot business

international airport, diverse residential areas, expansive parks, and a multitude of recreational and cultural activities. www.co.wayne.mi.us Genesee Regional Chamber of Commerce (Flint) The voice of business and community advocacy in Genesee County. www.thegrcc.com Hosted by:

incubator/accelerator that provides support and assistance to nurture the formation,

®

survival, and growth of innovative, entrepreneurial, life science businesses. www.kazoosmic.com

www.michigan.org www.michbio.org

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BioMatters | Spring 2011

PRESIDENT’S MESSAGE

P R O F E S S I O N A L S TA F F

Michigan’s Biosciences Industry Welcomes You!

Michigan is home to a strong biosciences industry with a rich legacy of industry

leaders like Parke-Davis Pharmaceuticals-Upjohn/Pharmacia-Pfizer, Stryker, Perrigo, Dow Chemical, Kellogg, Terumo, MPI Research, Emergent BioSolutions, Neogen, BD and Beckman Coulter, among others. Our over 550 bioscience companies, academic research centers and clinical institutions reflect the breadth of pharma/biotech, medical devices/equipment, research products and diagnostics, informatics, ag-bio, bio-defense, industrial and environmental biotechnology, medical/laboratory testing and clinical research.

Our bioscience companies have a remarkable track record of investment, growth,

and return, despite recent economic challenging times. Michigan has witnessed an overall 13% increase in number of bioscience companies and an almost 6% increase in bio-industry employment in the last ten years. More than 120 companies launched in the same period.

The State of Michigan provided $325 million in support to bioscience companies

during the last decade, as well as an additional $46 million of investment by the state’s fund-of-funds that were directed to biotech start-ups. Coupled with other state resources like our Pre-Seed Capital Fund, Micro-Loan Program, Angel Investor Tax Credit, and an unrivalled statewide network of SmartZonesSM that provide business acceleration and wet lab incubator services, means that Michigan’s biosciences companies benefit from a strong ecosystem that supports commercial growth from ideas to markets.

The current issue of BioMatters continues to present the faces, organizations and

Stephen T. Rapundalo, Ph.D. President and CEO srapundalo@michbio.org 734.527.9144 Jayne Berkaw Director, Marketing and Communications jayne@michbio.org 734.527.9147 Heather Kusiak Manager, Operations and Membership heather@michbio.org 734.527.9150 Nancy Marcotte Manager, Finance nancy@michbio.org 734.527.9145

initiatives that represent Michigan’s biosciences community. Whether you’re already here or looking in from the outside we welcome you to learn more about who we are, what we do, how we achieve it and where we’re going with our biosciences industry.

I invite you to visit us at Booth #1337 during the BIO International Convention in

Washington, DC from June 27-30, 2011. Or simply contact me at srapundalo@michbio.org and let MichBio, the state’s biosciences trade association, show you how to access companies, services, resources, markets and information related to our state’s robust

C O N TA C T I N F O R M AT I O N Physical Address 3520 Green Court, Suite 150 Ann Arbor, Michigan 48105-1579

bio-industry.

Mailing Address P.O. Box 130199 Ann Arbor, Michigan 48113-0199 Stephen Rapundalo, Ph.D. President and CEO, MichBio

Phone

SAVE THE DATE

734.527.9150

7th Annual MichBio Expo & Conference November 2-3, DeVos Place, Grand Rapids

CONFERENCE HIGHLIGHTS: • The Michigan Emerging Biosciences Showcase • Concurrent track sessions in Pharma, Medical Device, Emerging Business and Bio-Based Technologies

• • • • •

Bio-Policy Roundtable Manufacturing Session CEO Dinner Forum Poster Session Facility Tours and much more!

Fax 734.302.4933 Website www.michbio.org Email info@michbio.org

Over 70% of attendees are bio-executives.

Exhibitor/Sponsor Information and Reservations Contact Erin • 734.677.0503 • erin@michbio.org

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BioMatters | Spring 2011

C O R P O R AT E S P O N S O R S

O F F I C E R S , D I R E C TO R S A N D C O M M I T T E E S

Executive Officers

P L AT I N U M 速

Chairman Stephen Munk, Ph.D. Ash Stevens, President and CEO Vice Chairman David Zimmermann Kalexsyn, Inc., Chief Executive Officer

GOLD

President and CEO Stephen T. Rapundalo, Ph.D. MichBio, President and CEO Secretary Christina DeHayes Asterand plc, General Counsel

S I LV E R

MEDIA

Ash Stevens, Asterand, Lumigen, Phadia US, Inc., Terumo, Varnum

FRIEND

Kalexsyn

SUPPORTER

Biotechnology Business Consultants, sanofi-aventis U.S., West Michigan Science & Technology Initiative

BioMatters | Spring 2011

Jennifer Rice, D.V.M., MSc, Ph.D. Neogen Corporation Senior Scientific Officer John J.H. Schwarz, M.D. Family Health Center Physician, Former U.S. Representative Christopher J. Stein Ferndale Pharma Group, Inc. Senior Vice President, Corporate Development

Directors

Eric Stief AutoHarvest Foundation Senior Vice President

David Felten, M.D., Ph.D. Beaumont Hospitals, Research Institute Vice President, Research and Medical Director

Karen Studer-Rabeler Coy Manufacturing/ Coy Laboratory Products General Manager Vice President, Business Development

James Freeman, Ph.D. Pfizer Animal Health Vice President, Laboratory Sciences

Bill Worzel Everist Genomics, Inc. President and CEO

Teri Grieb, Ph.D. U of M Medical School, Office of Research Director of Administration for Research Office of Research and Graduate Studies

David Zimmermann Kalexsyn, Inc. Chief Executive Officer

Mark Kielb Altarum Institute Chief Financial Officer

PATRON

Stephen T. Rapundalo, Ph.D. MichBio President and CEO

Treasurer Matthew L. McColl Ernst & Young LLP, Partner

J. Patrick Elliott Terumo Cardiovascular Systems Corp.

Vice President, Business Development

BRONZE

Stephen Munk, Ph.D. Ash Stevens President and CEO

Paul Morris AlixPartners, LLP Finance Manager, National Enterprise Improvement Practice Brent Mulder, Ph.D. Van Andel Research Institute Director, Office of Technology Transfer

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Committees Clinical Trials Financial Services and Risk Management Intellectual Property and Legal Membership and Marketing Programs Public Policy

Debra Pratt ‘13 Biochemistry Co-op: JHP Pharmaceuticals

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8/19/10 9:39:14 PM

BioMatters TA B L E O F C O N T E N T S

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MichBio Corporate Sponsors, Officers, Directors and Committees

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Feature Story:

A New Era

for Michigan: Economic Gardening to Grow State’s Bio-Industry

15

New Governor Looks to Cultivate Climate for Success

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26

Pharmaceu TIcals and

therapeutics: Problem-Solving Specialty Drug Maker is a Life Saver

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ECONOMIC DEVELOPMENT: From Mind to Market Michigan’s Robust Framework for Moving Companies Forward

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Alternative Business Model Drives Private Wet Labs

PROFILE: Ash Stevens Builds on Strengths...and Wins!

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ENTREPRENEURS:

After the Elevator Speech

WORKFORCE DEVELOPMENT: A Strong Pipeline Feeds Michigan’s Wealth of BioTalent Incentives Matter: Economic Development Agencies Work to Attract and Retain Bioscience Jobs and Talent

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Guest Opinion: The Bio-Industry — An Indisputable and Essential Economic Driver for Michigan

DIRECTORY & RESOURCE GUIDE

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The following MichBio members are featured in this issue of BioMatters: AlphaCore Pharma, LLC, Ann Arbor SPARK , Ascendant MDx, Barbara Ann Karmanos Cancer Center, Genemarkers, LLC, Ferris State University, Grand Valley State University, Henry Ford Community College, Intervention Insights, Medical Main Street, Michigan Economic Development Corp., Michigan Research Institute, Michigan Small Business & Technology Development Center, Michigan State University, Michigan Technological University, Neogen, Pfizer, PhRMA, Southwest Michigan First, Southwest Michigan Innovation Center, Tangent Medical Technologies, Inc., TechTown, University of Michigan, Wayne State University

Subscribe to BioMatters:

Visit www.michbio.org and click “Register Now” or call 734.527.9150.

ADVERTISERS Ash Stevens ................................................................ 8 C2RS ........................................................................ 16 Doeren Mayhew ...................................................... 17 Grand Valley State University ................................. 23 Kalexsyn, Inc. ........................................................... 23 Kettering University .................................................. 7 MichBio .................................................................. BC

Michigan Economic Development Corp. ............. IFC Michigan State University ......................................... 8 MPI Research .......................................................... 11 Oakland University ................................................. 17 Pharmacision .......................................................... 16 Pfizer ...................................................................... IBC Quest Research Institute ......................................... 23

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Rader, Fishman & Grauer ....................................... 16 Southwest Michigan Innovation Center ................ 11 Terumo Cardiovascular Systems ............................ 17 Trialon Corporation ................................................ 23 University of Michigan ............................................. 4 West Michigan Science & Technology Initiative ..... 1

BioMatters | Spring 2011

Bioscience

Industry is Broad, Deep in Michigan

That was the conclusion of a

2009 study released by PhRMA and MichBio, which found that “Michigan has the assets to support and grow bioscience, particularly in the presence of its major research universities.” In FY 2008, bio-industry payrolls reached nearly $2.5 billion and contributed $9.5 billion to the state’s GDP, while directly employing more than 37,000 people. Total academic bioscience R&D expenditures were $951 million in 2008.

Michigan is home to more than 550 bioscience

enterprises from pharmaceuticals and therapeutics (including nutraceuticals), medical device and equipment companies, diagnostics and research products, to bio-based technologies and bio-agriculture. The state’s contract research industry alone has the depth to handle business globally at any stage of pharmaceutical and medical technology development.

Michigan’s SmartZonesSM fuel a robust pipeline

of bioscience companies through their business and wet-lab incubators — 126 new start-ups since 2002 alone. Collaborations between local universities, industry, research organizations, government agencies and other community resources nurture entrepreneurial ventures with business assistance and access to funding sources. Michigan’s bio-companies have been fueled by $440 million in venture capital investment from 2004 to 2009. From the tip of the Upper Peninsula to the bustling Lower Peninsula, the state’s vibrant biosciences industry is “Pure Michigan.”

The study points out that

$951

bioscience expenditures totaled million

with industry payrolls reaching nearly BioMatters | Spring 2011

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$2.5 billion.

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BioMatters | Spring 2011

F E AT U R E S TO RY

A New Era for Michigan:

Economic Gardening to Grow State’s Bio-Industry

BioMatters | Spring 2011

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If biosciences leaders in Michigan could harvest a dream team to lead state government, it might look something like this:

By Rick Haglund

The governor would be a successful technology business executive and venture capitalist who knows what it takes to grow bio-related companies. Rather than a skilled orator, the governor would sound more like a CPA and might even come off as being kind of nerdy.

His pick to run the state’s economic development agency would possess deep experience on the local level in a region rich with biotechnology and medical-related businesses, supplemented by life sciences research at one of the world’s premiere research universities.

Position players in his economic development agency would specialize in talent retention and acquisition, entrepreneurship and strategic partnerships.

That’s exactly what the state is getting in the new administration of Gov. Rick Snyder, who took office on Jan. 1.

Snyder, who was president and interim CEO of computer-maker Gateway Inc. in the 1990s, returned to his native Michigan in 1997 and started Ardesta LLC, a $100 million venture capital fund that invested mainly in technology companies.

“It’s a field I enjoyed investing in and did pretty well,” Snyder said in a telephone interview with BioMatters. “We’ve come a long way in the past couple of decades in Michigan” in the biosciences. “We’ve developed a strong infrastructure.”

MEDC Holds Reins for State Bioscience Matters

As it has in past administrations, the major support for biosciences will be housed at the Michigan Economic Development Corporation, headed by Mike Finney.

A native of Saginaw, Finney was serving as president and CEO of Greater Rochester Enterprise, an economic development agency in Rochester, N.Y., when Snyder recruited him five years ago to run Ann Arbor SPARK. Snyder was chairman of the Ann Arbor economic development agency at the time.

Michigan Governor Rick Snyder

says the state has built

a strong biosciences infrastructure.

Mike Finney, CEO of the MEDC, promotes a multi-pronged approach to help small, growth-oriented companies expand and create jobs – “economic gardening.”

During his campaign for governor, Snyder criticized the MEDC for its growing use of pricy tax incentives to entice companies to expand or locate in Michigan during the eight years Jennifer Granholm served as governor. Snyder was a former chairman of the MEDC executive committee during the administration of Gov. John Engler.

Virtually all business tax credits in the complex MBT would be eliminated in favor of a simplified profits tax that Snyder maintains will lead to more jobs and a fundamentally stronger state economy.

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Michigan granted $220.9 million in brownfield and Michigan Economic Growth Authority tax credits just in the past year. Those credits and hundreds more granted in previous years will cost the state nearly $800 million in tax revenue it otherwise would have collected in 2012 and 2013.

Snyder proposed replacing the Michigan Business Tax, which taxes gross receipts and profit, with a 6 percent corporate income tax.

The legislature approved the sweeping change in May. Virtually all business tax credits in the complex MBT will be eliminated in favor of a simplified profits tax that Snyder maintains will lead to more jobs and a fundamentally stronger state economy.

Only large “C” corporations will pay the corporate income tax. All other types of businesses, including partnerships, sole proprietorships and limited liability corporations will not be subjected to the tax, which includes start-up and other young biosciences companies.

The new corporate income tax will take effect in October.

“We’re doing away with a lot of the incentive programs,” Finney said. “Our focus is going to be on reducing the cost of business for everybody.”

Three-Legged Stool Strategy Guides Support for Biosciences

The MEDC’s new economic development strategy essentially is a three-legged stool that focuses on supporting existing businesses in the state, attracting new investment and promoting a more entrepreneurial economy.

Granholm’s targeted industry strategy, which focused state resources on life sciences, advanced automotive technologies, alternative energy and homeland security also is being eliminated.

BioMatters | Spring 2011

F E AT U R E S TO RY

But Finney said he sees life sciences and other bio-related companies as an important segment of the state’s economy. “We want to be opportunistic,” he said. “The industry has grown substantially over the past 10 years.

It’s important to keep it on our radar screen.”

The state isn’t totally eliminating financial support for companies in the biosciences sector. It’s still spending $25 million a year in an annual competition for businesses and researchers seeking funding to commercialize life sciences technologies.

Michigan also will have roughly $50 million available to spend on incentives to attract new business investment to the state.

And the MEDC is continuing several of its small-business lending initiatives, including the successful capital access program, Finney said.

Started more than 20 years ago by Gov. James Blanchard, the capital access program uses a small amount of state money to leverage bank loans for companies having difficulty finding financing. The program has generated more than 11,000 business loans over the past 22 years. It has used $24.3 million in state money to leverage $628.7 million in bank funding.

But about 60 percent of the state’s economic development work in the Snyder administration will be in the area of “eco-

BioMatters | Spring 2011

nomic gardening,” a multipronged approach to help small, growth-oriented companies expand and create jobs.

Economic gardening was pioneered by local economic development officials in Littleton, Colo. who grew frustrated over watching companies that had been given tax incentives to locate there leave after the credits expired. The city now relies entirely on economic gardening for job creation.

“We want to be opportunistic,” he (Finney) said. “The industry has grown substantially over the past 10 years. It’s important to keep it on our radar screen.”

“It’s a new frontier — almost a new profession that’s being created,” Rob Fowler, president of the Small Business Association of Michigan, said about economic gardening.

Economic gardening is far more complex than just calling on companies and asking what Lansing can do to help them. It involves establishing a new toolbox of services, including market research, financing help and expert advice on managing growth.

Rather than offering those services itself, the MEDC will rely on universities

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and organizations such as MichBio and the Michigan Small Business and Technology Development Center to provide technical and business expertise to growing companies on a contract basis.

His model for assisting companies is the Michigan Manufacturing Technology Center, a Plymouth-based organization that contracts with specialists in finance, accounting, manufacturing, marketing and other disciplines to aid small-and-mediumsize manufacturers.

“The MEDC doesn’t have to become the expert in all these different areas,” Finney said. “We can contract with groups such as MichBio and the Michigan Small Business and Technology Development Center to provide companies with services as needed on a project basis.”

The MEDC’s attitude towards partnership with industry groups and regional organizations is a welcome sign. “We need an integrated ecosystem that brings together relevant stakeholders like MichBio to support bioscience company growth,” said Stephen Rapundalo, President and CEO of MichBio. “Doing so will bring to bear many strengths and resources in a coordinated manner, thereby making it easier for companies to gain the assistance they need.”

F E AT U R E S TO RY

New Governor Looks to Cultivate Climate for Success

Rick Snyder came back to his native Michigan 14 years ago looking

Those partnerships are what MEDC President Mike Finney calls “open

to grow and profit from the state’s technology industries, including

source” economic development. It’s an acknowledgement that wisdom

the biosciences.

about growing businesses resides mostly outside of state government.

His $100 million venture capital fund, Ardesta Ventures, invested

Throughout his campaign for governor, Snyder repeatedly talked

in several of Michigan’s most successful tech start-ups, including

about the need to change Michigan’s tax structure, and to make the

HandyLab, an Ann Arbor diagnostic testing firm.

MEDC more focused on helping entrepreneurs and less dependent on

doling out tax incentives.

Avalon Investments, another Snyder venture capital firm, in-

vested in HealthMedia, a healthcare software business that was sold

Snyder said he sees a bright future for the biosciences. The industry not only has grown in terms of the number of companies, but also has expanded broadly across the state.

to Johnson & Johnson in 2008. HandyLab and HealthMedia were spun out of research at the University of Michigan.

But now that he’s governor, Snyder says his goal is to create a

climate in which all kinds of companies can succeed.

“I’m more into creating the best environment for all business and

letting free enterprise work,” Snyder said in a telephone interview with BioMatters. “How can we develop partnerships with the private

sector? How do we unleash free enterprise?”

in May, will replace the complex Michigan Business Tax, which has

profit and gross receipts components, with a simpler 6 percent

To Snyder, the answers to those questions are found in revamping

Snyder’s business tax plan, which was approved by the legislature

the state’s business tax structure and overhauling the Michigan

corporate income tax. The plan will exempt most small firms

Economic Development Corp. to work more closely with trade groups

and cut business taxes overall by $1.7 billion.

and local economic development agencies.

“Our business tax plan is about creating a level playing field,”

Snyder said. “It’s a flat, simple income tax. Young companies that aren’t

“I’m more into creating the best environment for all business and letting free enterprise work,” Snyder said in a telephone interview with BioMatters.

“How can we develop partnerships with the private sector? How do we unleash free enterprise?”

making money yet shouldn’t have to deal with a gross receipts tax.”

But Snyder’s budget plan for fiscal year 2012 proposes about $1.5

billion in spending cuts, including a minimum 15 percent reduction in university funding. That could threaten some of the research and other work done at the universities that leads to new companies and products in the biosciences, though the bulk of such efforts is supported by federal NIH funding typically.

Snyder said the cuts, though painful, are necessary to restore

Michigan’s long-term financial health, and allow future investments A background

in universities and other institutions that aid the economy.

that includes investing

in successful bioscience ventures gives

Governor Rick Snyder

unusual insight

“In the short term, we need shared sacrifice to straighten out

the structural problems we have,” he said. “But by 2013, the higher

into the needs of growing companies.

education cuts are over with.”

One of Michigan’s challenges in developing entrepreneurial busi-

nesses is that successful young companies often are sold to larger companies and moved out of state. That happened most recently with HandyLab, which was sold in 2009 to New Jersey medical devices giant Becton Dickinson and Co. for $275 million. Snyder was chairman of HandyLab at the time of the sale.

“When companies are moved out of state, the number one reason

usually is talent and then capital availability,” Snyder said. “We have the technical talent. We need to work on acquiring more management talent and venture capital.”

But Snyder said he sees a bright future for the biosciences. The

industry not only has grown in terms of the number of companies, but also has expanded broadly across the state.

“We have a good legacy and a strong core,” he said. “We have

labs and specialty equipment available for start-up companies. There are a lot of good opportunities here. We’ve come a long ways.”

15 11

BioMatters | Spring 2011

F E AT U R E S TO RY

Officials at several companies and nonprofits that help young biosciences companies grow said they support the Snyder administration’s economic development strategy.

“In general, I think it will have a positive impact regardless of industry,” said James Richter, president of the Michigan Research Institute, an Ann Arbor-based nonprofit corporation that commercializes biosciences research and operates a wet lab business incubator. “The tax change unburdens a lot of companies.”

Some 95,000 companies that now have tax liability under the MBT wouldn’t even have to file a tax return under the profits tax. The convoluted MBT and Granholm’s targeted industry approach wasn’t sustainable, said Kenneth Massey, director of research and clinical operations at Lifeline Ventures, a Farmington Hills-based company that provides venture capital and leased space to life sciences companies in mid-to-late stages of growth.

“The problem is government isn’t particularly skilled at business development,” Massey said. “If you level the playing field in the tax structure, you start to allow companies to develop. I think that’s where we want to be.”

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BioMatters | Spring 2011

E conomic development

From Mind to Market Michigan’s Robust Framework for Moving Companies Forward Financial Counseling?

Networking?

Access to Capital?

Staff?

Business Mentoring?

Wet Lab?

Equipment?

Office Essentials?

Training?

BioMatters | Spring 2011

18

In 2003, a group of community leaders from Kalamazoo showed up unexpectedly at a Michigan Life Sciences Corridor Steering Committee meeting with an emergency request for $2 million in funding. Pfizer had just announced it was cutting 1,200 jobs in Kalamazoo. Local officials said they needed fast cash to fund an ambitious plan that would allow Pfizer scientists to stay in Kalamazoo and start their own companies.

By Rick Haglund The funding from Michigan’s portion of a federal tobacco lawsuit settlement was granted, aiding the opening that year of the Southwest Michigan Innovation Center, a 69,000 square-foot life sciences business incubator and accelerator that operates on a $2 million annual budget.

Located in the Western Michigan University Business Technology Research Park, the modern, two-story, brick-and-steel structure provides wet labs and professional office space young biosciences companies otherwise could not afford.

“Having a real address is critical in the granting process,” he said. “The federal government doesn’t like to send checks to a home address.”

“We are in such a nice setting that when our companies host potential investors; it offers them a lot of credibility,” said Robert DeWit, president and chief executive officer of the Southwest Michigan Innovation Center.

Since it began operations nearly a decade ago, the Southwest Michigan Innovation Center has graduated five companies, resulting in the creation of 342 jobs in the area.

It’s also important for start-up companies seeking federal grants to have a business address, which the Southwest Michigan Innovation Center provides them. “Having a real

address is critical in the granting process,” he said. “The federal government doesn’t like to send checks to a home address.”

Incubators PROVIDE Key Services The Southwest Michigan Innovation Center is just one of more than a dozen publicly supported incubators providing crucial services to biosciences start-ups. Most are located in the state’s 15 SmartZones , which are technology clusters that promote collaboration among universities, industry, research organizations and government.

Since it began operations nearly a decade ago, the Southwest Michigan Innovation Center has graduated five companies, resulting in the creation of 342 jobs in the area.

The center currently has 15 tenants and has provided services to 25 other companies.

DeWit said demand for space is increasing as Michigan recovers from a deep recession.

SM

The Southwest Michigan Innovation Center offers bioscience startups wet lab space and business accelerator services that support the development of both their science and their business.

19

BioMatters | Spring 2011

economic D evelopment

Hilary Wagner,

a scientist at

CeeTox,

an incubator tenant at

Kalazamoo’s Southwest Michigan Innovation Center,

vitro toxicity screening of potential drug candidates and chemicals.

Increasingly, incubators are linking with each other to provide a broad array of services.

For entrepreneurs, that means the ability to access programs and expertise that may not be available at a local incubator.

“One of the things I think we do particularly well is offer phenomenal support from a business or a science perspective, or a combination of the two,” said DeWit, who was a research scientist for 25 years, mostly at Pfizer.

Increasingly, incubators are linking with each other to provide a broad array of services. For entrepreneurs, that means the ability to access programs and expertise that may not be available at a local incubator.

“We are being encouraged (by state officials) to collaborate closely in a way we perhaps haven’t done before. I think that’s quite exciting,” said Randal Charlton, executive director of TechTown, an incubator and business accelerator in Detroit. “We’re developing a statewide network that can be quite powerful, particularly for life sciences.”

TechTown, a brainchild of then Wayne State University President Irvin Reid, was incorporated in 2000 and opened its first incubator in midtown Detroit in 2004.

BioMatters | Spring 2011

performs a biochemical assay test.

That incubator, known as TechOne, is a five-story, 120,000 square-foot building designed by renowned architect Albert Kahn in the early 1920s. It formerly housed Chevrolet Creative Services and was donated to TechTown by General Motors Co. TechOne has 243 current business tenants, which may seem surprising given the negative publicity about Detroit’s declining population and financial woes.

“We’re full,” Charlton said. “Many of our tenants are very early stage companies.”

Among them are MitoStem, which is engaged in stem cell research; ApoLife, which is using yeast expression technologies in the development of therapeutic antibodies to treat cancer and other diseases; and Clean Emission Fluids Inc., a company that manufactures equipment for biodiesel fueling and other fluids.

Those companies take advantage of a variety of services, including wet lab space, financing and management help, access to technology, and even more routine services such as printing.

TechOne Printing is a low-cost service that can print everything from business cards to books and is available to entrepreneurs not located in the incubator. Charlton jokingly refers to it as “Kinko’s on steroids.”

A second incubator, known as TechTwo, is under construction in a building that formerly housed a Cadillac dealership. The

20

CeeTox

is a

CRO

focused on in

building, which has a waiting list of companies ready to occupy it, is scheduled to open later this year.

The two TechTown incubators are part of a 43-acre technology park that includes lofts, a charter high school and offices occupied by Wayne State and Henry Ford Health System.

Companies take advantage of a variety of services, including wet lab space, financing and management help, access to technology, and even more routine services such as printing.

TechTown’s biggest success story is its first tenant, Asterand, which was founded

by Charlton in 2000. The company, which provides human tissue for drug discovery scientists, merged with English company Pharmagene and went public in 2006. Its stock is traded on the London Stock Exchange.

Charlton retired from Asterand in 2006 to become TechTown’s executive director.

Ann Arbor SPARK, a local economic development agency, operates three business incubators in Washtenaw County. One of them, the Michigan Life Science and Innovation Center, houses 12 businesses, including nine life sciences start-up companies.

A broad-based coalition made possible the Michigan Life Science and Innovation Center in Plymouth 57,000 sf of incubator space including state-of-the-art labs, offices and conference rooms.

Skip Simms, vice president of entrepreneurial business development at SPARK, said the state’s creation of a life sciences corridor more than a decade ago and incubator funding from the state through SmartZones are starting to pay off.

SM

The state’s creation of a life sciences corridor more than a decade ago and incubator funding from the state through SmartZonesSM are starting to pay off.

“We’re creating a cluster and I think that cluster is beginning to blossom,” he said.

“We’re not as strong as Boston or San Diego, but we’re on our way.”

There are incubators and business accelerator services available in SmartZones throughout the state, from Detroit to Houghton in the Upper Peninsula.

SM

Detroit’s TechTown incubator currently houses 243 tenants, and it is renovating another building to add even more space. Tissue banking success story, Asterand, was its first tenant.

with its

MI-SBTDC SUPPORTS ENTREPRENEURS STATEWIDE But start-ups and other young companies with growth issues don’t need to be in an incubator to get help.

That’s where the Michigan Small Business & Technology Development Center comes in. Known by the acronym MI-SBTDC, the center provides counseling, training, research and advocacy for new ventures, existing small businesses and innovative technology companies in 30 locations around the state.

Some of those locations are at incubators and accelerators located in SmartZones .

“We’re an overarching state entity that provides services for everyone,” said Sandra Cochrane, a technology business consultant at MI-SBTDC, which is headquartered at Grand Valley State University in Grand Rapids. “We work with the incubators and entrepreneurs, offering another layer of support.”

SM

The center counsels about 6,000 businesses a year. In 2009 MI-SBTDC helped client companies raise about $250 million in capital. It also helps local communities establish incubators and provide other services to entrepreneurs, start-ups and growth-oriented businesses.

“Clients are served best when they are able to connect with the ecosystems of their local communities,” said Cochrane, who heads the life sciences team at MI-SBTDC. The major need continues to be financing, Charlton said. However, Michigan’s capital formation outlook has grown, with many more venture capital firms in place, and investors from across the country recognizing exciting opportunities with good ROI prospects.

Charlton said many entrepreneurs also aren’t aware of the extent of low-cost help they can get from universities. Incubators like TechTown are, in part, access portals to university research and other services. “Collectively, we’ve got phenomenal resources,” he said.

“Clients are served best when they are able to connect with the ecosystems of their local communities,” said Cochrane, who heads the life sciences team at MI-SBTDC.

Sandra Cochrane

21

BioMatters | Spring 2011

economic D evelopment

Alternative Business Model Drives Private Wet Labs

Supplementing the more than a dozen state-sponsored

It also rents space to Ascendant MDx, which provides

business incubators and accelerators are a small, but growing,

molecular diagnostic testing services to healthcare providers.

network of private-sector companies that play an important

It recently moved work from Illinois and Tennessee and employs

role in helping biosciences companies grow.

about 150 people at the site.

One company that combines elements of the venture

Lifeline’s approach appeals to founders who want to concentrate on developing a product and not spend time on obtaining continuous rounds of financing.

capital and incubator models is Farmington Hills-based Lifeline Ventures, a firm that offers 325,000 square feet of lease and incubator space on a 10-building campus, as well as providing venture capital.

Venture capital firms usually provide a certain level of

financing, such as pre-seed or mezzanine financing. Many

venture capital companies also look for a certain rate of

ness plans of companies from around the country. It hopes to

return or exit date when they can recoup their investment.

invest in some and move them to Michigan.

Lifeline Ventures takes a more patient approach, said Ken

Massey said Lifeline Ventures has reviewed about 100 busi-

Another approach to product commercialization and business

Massey, director of research and clinical operations. While

development is being taken by the Michigan Research Institute,

it likes to acquire a majority stake in the companies in which

a private nonprofit corporation started in 2002. Its niche is in

it invests, Lifeline Ventures has no stringent timing criteria.

scouring universities, federal labs and private companies for technologies that can be commercialized in conjunction with

One company that combines elements of the venture capital and incubator models is Farmington Hills-based Lifeline Ventures, a firm that offers 325,000 square feet of lease and incubator space on a 10-building campus, as well as providing venture capital.

business partners.

“We put together teams of experts, provide the financing

and launch new companies,” said Michigan Research Institute Founder Jim Richter.

The institute, which operates a wet lab incubator in Ann

Arbor, is partnering with Diamond Automation of Michigan on a microwave technology to pasteurize eggs, protecting them

“We don’t look for a specific rate of return or exit date,”

from salmonella and avian flu.

he said. “We actually look at an investment as if we will be

there until there is an offer to buy us out or there is a path

Center for Regenerative Medicine in Plymouth, a wet lab

to commercialization. It’s a little outside the box.”

incubator for companies performing adult stem cell research.

Many entrepreneurs are unwilling to give up majority

“We put together teams of experts, provide the financing and launch new companies,” said Michigan Research Institute Founder Jim Richter.

control in their companies. But Lifeline’s approach appeals to founders who want to concentrate on developing a product and not spend time on obtaining continuous rounds of financing.

Michigan Research Institute’s latest project is the Michigan

Lifeline also provides services such as marketing, human

resources and obtaining patents. Manoj Bhargava, who also

developed the 5-Hour Energy drink, founded the company

grant, is expected to open this fall.

in 2007 as MicroDose Life Sciences.

Farmington Hills, specializes in providing business assistance

Staffed mainly by former Pfizer Inc. scientists and employ-

The lab, backed by Wayne County and a $2.2 million federal Another private business incubator, Vo2 Ventures LLC, in

ees, Lifeline has made only a few investments, including one in

for healthcare, biotechnology and life sciences companies.

UltraLinq Healthcare Solutions Inc., which offers a web-based

system for viewing and storing medical images such as ultra-

the company offers venture capital financing, entrepreneurial

sounds.

training, and legal, accounting and other business services.

BioMatters | Spring 2011 2011

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BioMatters | Spring 2011

D ATA

MI Bio-Industry Quick Facts

Academic Bio-Research University Research Corridor

Bio-Industry Investment, Commercialization Resources & Incentives

37,180

Total R&D:

$323 million

# Spin-Off Jobs:

(#11 in the nation)

# Bio Companies & Organizations:

>540

# Bioscience Jobs:

102,609

$1.6 billion $951 million

Total Payroll:

# of Biosciences Degrees:

$2.5 billion Economic Impact:

(#10 in the nation)

5,548

(#8 in the nation in 2008)

$9.5 billion

# of Bioscience-Related Patents:

Total Bioscience Start-Ups Since 2002:

(2004-09)

126

BioMatters | Spring 2011

(1999-2009)

VC Investments:

Biosciences R&D:

Average Bioscience Salary:

$73,394

Life Sciences Corridor Fund – 21st Century Jobs Fund:

1,871

24

$268.7 million (2002-07)

Total $ Raised:

$68.8 million

(#11 best in the nation 2009)

21st Century Investment Fund:

$109 million fund-to-funds $46 million to biosciences

a sample of Bioscience Companies in Michigan n Accuri Cytometers

n Housey Pharmaceuticals

n Oxford Biomedical

n Ash Stevens

n Jasper Clinical R&D

n Perrigo

n Assay Designs

n JHP Pharmaceuticals

n Pfizer

n Asterand

n Kalexsyn

n Phadia

MI Pre-Seed Capital Fund

n Atek Medical

n Kellogg

n Pioneer Surgical

MI Microloan Fund

n Beckman Coulter

n Lycera

n Rockwell Medical

Angel Investor Tax Credit

n Dow Chemical

n Medbio

n Stryker

R&D Tax Credit

n Emergent BioSolutions

n MPI Research

n Terumo CVS

R&D and Bio-Manufacturing Tax Exemption

n Esperion Therapeutics

n NanoBio

n Vestaron

NOL Carryover

n Everist Genomics

n Neogen

SBIR Match

n Ferndale Pharma Group

n Orchid Orthopedic Solutions

Venture Michigan Fund:

$95 million fund-to-funds

(2007-09)

Distribution of Michigan bio-companies by sector Pharma & Therapeutics

22%

Medical Devices/Equipment

36%

Research & Development

19%

Testing/Medical Labs

5%

Information Technology

7%

AgBio & Industrial Biotech

10%

AgBio & Industrial Biotech Information Technology

Pharma & Therapeutics

Testing/Medical Labs

Research & Development Medical Devices/ Equipment

25

BioMatters | Spring 2011

P harmaceuticals and therapeutics

Problem-Solving Specialty Drug Maker is a Life Saver

According to the 2009 Drug Trend Report published by Express Scripts, the use of specialized drugs is projected to grow 10-12 percent through 2012, primarily due to approval of novel therapies for conditions that are currently unmet. The report also says spending on specialty drugs, which include the top three therapy classes—inflammatory conditions, multiple sclerosis, and cancer—increased 19.5 percent from 2008 to 2009.

by Tom Beaman According to the 2009 Drug Trend Report published by Express Scripts, the use of specialized drugs is projected to grow 10-12 percent through 2012, primarily due to approval of novel therapies for conditions that are currently unmet. The report also says spending on specialty drugs, which include the top three therapy classes—inflamma-

BioMatters | Spring 2011

Spending on specialty drugs, which include the top three therapy classes—inflammatory conditions, multiple sclerosis, and cancer—increased 19.5 percent from 2008 to 2009.

26

tory conditions, multiple sclerosis, and cancer —increased 19.5 percent from 2008 to 2009.

Specialty drugs were not always such big business. They were hardly even a cottage industry in 1975 when Phil Hagerman went to work for his father at Diplomat Pharmacy in Flint. But Hagerman knew there would always be a need for customized pharmaceutical services.

“We started out as a traditional pharmacy, but we were always one that worked to solve problems,” says Hagerman, who today is Diplomat’s Specialty Pharmacy’s president and CEO. “If the doctor asked me to carry a product that was complicated and expensive, I just simply found a way to do it. We very quickly became a niche player for complicated therapies that the average pharmacy would not fill. We were one of the early ones in the nation to start tackling therapies for AIDS [by finding a way to atomize the antibiotic Pentamidine to treat pneumonia associated with the disease].”

Today, with 100,000 clients, Diplomat is the largest privately held specialty pharmacy in the nation, with locations in Michigan, Illinois, Florida and California.

Named one of the fastest growing private companies by Inc. Magazine, Diplomat’s sales rose from $370 million in 2009 to $580 million in 2010. Hagerman forecasts sales of over $800 million in 2011.

“If the doctor asked me to carry a product that was complicated and expensive, I just simply found a way to do it.”

“Many of the drugs we dispense are limited distribution, which means that only certain people in the country are contracted

Headquartered

in

Phil Hagerman, president and CEO of Diplomat Pharmacy, has built a successful pharma business by being a problem solver.

to have them, Hagerman says.” We proactively manage patients who are seriously ill or who are on complex, tightly controlled therapies in a way that traditional drugstores are not able to do.”

Specialty drugs are just that – special.

They are not the high-volume, low-margin hypertensive or statin products that are routinely dispensed from the corner drugstore. A four-dose cancer treatment can cost $120,000. “This is the niche of specialty pharmacies,” says Eldon Edge, R.Ph., interim director of Pharmacy at Spectrum Health in Grand Rapids. “If you have a dose of a drug that costs thousands of dollars, you don’t want somebody preparing it wrong, mixing it wrong, dropping it. You want that very closely managed. You also want the pharmacy that’s dispensing it to understand all of the ramifications of the drug’s administration. They have to be very involved.”

Diplomat coaches patients on how to recognize and manage side effects, such as HandFoot Syndrome, a rash related to certain cancer therapies like Xeloda. The rash indicates that the drug is working, but it is often so severe

that patients must be taken off therapy. “If we can coach the patients on how to manage the rash, then they don’t have to stop the therapy and they have a much higher level of success,” says Hagerman. Diplomat also produces compliance packaging for complicated HIV/ AIDS therapies that simplify dosage and dispensing regimens and can increase the drugs’ effectiveness.

“If you have a dose of a drug that costs thousands of dollars, you don’t want somebody preparing it wrong, mixing it wrong, dropping it. You want that very closely managed.”

In 2010, Diplomat acquired 550,000 sq. ft. of space in the former General Motors Great Lakes Technology Centre in Flint, and announced plans to hire up to 1,000 new employees. “We’ve dramatically expanded our Michigan capabilities,” Hagerman says.

“Moving forward, 75 percent of our services will be managed and dispensed from our location in Genesee County. This building will allow us to grow and expand over the next ten years.”

Flint, MI, Diplomat

is the largest privately held specialty pharmacy in the

U.S.

27

BioMatters | Spring 2011

records for Ash Stevens. The privately held company’s revenue

profile

grew from $13.5 million in 2008 to $23.4 million in 2010.

“Our strengths are technical and regulatory competence

coupled with a very good system of project management,” says Munk. “Worldwide, we have…three thousand competitors. Since January 2003, the FDA has approved around 100 new chemical entities for the world. We make three of those right here in Michigan, and typically those products are sole-sourced. We’ve had 11 FDA approvals in our corporate history. That tells you we really are competent scientists, and we have the regulatory piece under control.”

The three API’s for which Ash Stevens received government

approval - azacitidine (Vidaza), bortezomib (Velcade), and cloUnder

the watch of

Dr. Stephen Munk, Ash Stevens president and CEO, 73.3 percent between 2008 and 2010.

farabine (Clolar) - all benefited from the firm’s fast track program

the company’s revenues jumped

that helps drug companies navigate the FDA’s approval labyrinth and get their products into the market faster.

Ash Stevens Builds on Strengths...and Wins!

“There’s a lot of ‘i’s’ to be dotted and ‘t’s’ to be crossed,” he says. “Not only do you have to develop and validate a robust,

analytical procedures to demonstrate that the active ingredient and the drug product are stable. There are a huge number of

and off-load non-core responsibilities, they are increasingly turning

things that have to get done to get a drug approved, and we’re

to companies like Ash Stevens to fill the gaps in their expertise.

good at that.”

“Since January 2003, the FDA has approved around 100 new chemical entities for the world.

We make three of those right here in Michigan.”

Ash Stevens has approximately 30 clients and 20-30

development projects at various stages, from toxicology to Phase III clinical trials. To support this activity, and prepare for future growth, the company announced in 2010 a five-year, $20 million expansion to its manufacturing facility

Founded in Detroit in 1962 by Dr. Arthur Ash, who wrote Wayne

in Riverview, Michigan. That facility currently houses the bulk

State University’s first Ph.D. dissertation in chemistry, and Wayne

of the company’s 70 employees, including analytical and

State professor Calvin Stevens, the company’s initial strategy was

synthesis chemists, manufacturing, engineering, and regulatory

to provide contract research services to Walter Reed Army Hos-

specialists, and laboratories for drug development, production

pital, the National Institutes of Health, and the National Cancer

and quality control.

Institute. Today, Ash Stevens still has research programs funded

by the NIH, but its major focus lies in developing, registering, and manufacturing active pharmaceutical ingredients, or API’s, for clients in the life sciences industry.

and a very good understanding of the regulatory requirements.

you have to develop very accurate, precise and repeatable

As biotech and pharmaceutical companies adapt themselves to

new industry realities that force them to focus on their strengths

Munk attributes the success of Ash Stevens’ fast track

process to a well-developed project management approach

repeatable and consistent chemical process to make the drug,

by Tom Beaman

“A lot of people are good at discovering things and selling things,

and they can manage the development process, but there are a lot

Munk attributes the success of Ash Stevens’ fast track process to a well-developed project management approach and a very good understanding of the regulatory requirements

of very specialized things that go on in [that process] like chemical development, which is what we do,” says Dr. Stephen Munk, Ash

The new addition includes a 10,000-sq. ft. storage and materials

Stevens’ president and CEO. “We make commercial quantities of

handling facility and a new reactor bay to accommodate large-

the active pharmaceutical, the business end of the drug.”

scale API manufacturing. The expansion is expected to create

The Food and Drug Administration (FDA) has approved an

62 direct jobs and 142 indirect jobs. Munk says the company

average of 23 new drugs per year since 2001. This activity, along

will close its office and laboratory complex in Detroit in several

with growing demand for contract manufacturers that can safely

years and consolidate its operations in Riverview.

and reliably work with highly potent API’s, has resulted in sales

BioMatters | Spring 2011

28

entrepreneurs

A fter the

Elevator Speech

by Tom Beaman

This issue of BioMatters has already taken a look at the myriad services available to help Michigan bio-entrepreneurs evolve products from “Mind to Market� (see story page 18).

Here is a snapshot of five up-and-comers whose product ideas are marching down the path toward marketability and profit.

29

BioMatters | Fall 2010

J. Cesere, AnnArbor.com. photo credit Angela

entrepreneurs

Brian Krause, CSO, and Nadia Esmaeil samples at AlphaCore.

analyze protein

AlphaCore Pharma, LLC

Tangent Medical Technologies, Inc.

Pharma giant Pfizer shocked Michigan’s economy when it closed three facilities in 2007, eliminating over 2,000 jobs. But Pfizer’s move had a silver lining: it freed up hundreds of experienced scientists like Reyn Homan, Bruce Auerbach, and Brian Krause to pursue their own entrepreneurial dreams. Just months after learning their jobs were disappearing, Homan and his colleagues filed papers to launch AlphaCore Pharma, LLC in Ann Arbor.

In August 2008, Homan’s team licensed a patent from the National Institutes of Health’s Office of Technology Transfer that matched their expertise and had commercial potential — the use of a natural protein, lecithin-cholesterol acyltransferase (LCAT), to treat heart disease.

Tangent Medical Technologies, Inc. of Ann Arbor plans to inject itself into the medical device market with a new take on one of the most basic pieces of hospital equipment — the intravenous catheter.

Elyse Kemmerer, Ph.D., Tangent’s co-founder and director of business development, says she learned about the need for an improved IV catheter after spending a year embedded throughout the University of Michigan Hospital as part of the university’s post-grad Medical Innovation Center (MIC) fellowship program.

“We learned that many IV complications are due to micromovement of the catheter inside the vein,” Kemmerer says. “If you control the micromovement, you can extend the dwell time of the IV.”

“LCAT is an enzyme that circulates in everybody’s blood stream and helps make HDL, or ‘good’ cholesterol. The drug would be used for heart attack patients to greatly reduce their risk of having a second one.”

LCAT could also be used in enzyme replacement therapy for people who lack sufficient quantities of the protein naturally and often lose kidney function at a young age as a result.

AlphaCore is using a Federal Small Business Innovation Research (SBIR) grant and funds from other investors to take the project through Phase I clinical trial. At press time, Homan’s team was preparing to submit an Investigational New Drug (IND) application to the Food and Drug Administration (FDA). “We hope to get into clinical testing in humans by mid-year,” he says.

BioMatters | Spring 2011

Adrienne Harris (L), Elyse Kemmerer, and Steve White with their prototype NovaCath IV at Tangent Medical.

30

The company’s NovaCath IV device attaches more securely to the skin, reduces complex tubing, and better protects health care workers from exposure to bodily fluids.

Kemmerer and three colleagues from the fellowship program with engineering, medical, and business expertise formed Tangent Medical Technologies, Inc. in 2009. Initial funding came from angel investors, a Federal grant, and matching dollars from Ann Arbor SPARK and Michigan’s Automation Alley technology business association.

Tangent must still secure FDA approval for the NovaCath device, name a distribution partner, and pass muster with hospitals’ value analysis committees. But Kemmerer has high hopes that the device’s benefits and value will attract a market. “If we’re able to show hospitals that our device extends dwell times, that means they can spend less money on supplies, and patients will be more comfortable and will have fewer complications,” she says.

Affymetrix

microarrays used for high-throughput gene

Genemarkers.

Oncologists use Intervention Insights’ OncInsight service

The Delphinus SoftVue breast imaging device differentiates

to tailor cancer treatments for individual patients.

benign from malignant masses with a safe, comfortable and

Genemarkers, LLC

Intervention Insights

Genemarkers, LLC opened its doors in Kalamazoo in 2009, and it is already making an impact in the genomic services industry.

With only three full-time employees and a stable of contract consultants, Genemarkers has clients in academia and the pharmaceutical, biotech, and personal care industries. Revenue doubled from 2009 to 2010 and is expected to double again in 2011, says Anna Langerveld, Ph.D., Genemarkers owner and president.

“Our goal is to assist scientists and industry professionals in incorporating state-of-the-art genomics technologies into their R&D programs,” says Langerveld.

The average community oncologist in the U.S. sees over 400 patients a year during 5,100 individual visits. But at only 10-15 minutes per visit, doctors have precious little time to determine a treatment plan for their patients, and may rely only on 10-20 standard-of-care therapies.

OncInsight, an interactive information service offered by Grand Rapids start-up Intervention Insights, targets community oncologists who may not have access to the resources of an academic center. OncInsight makes available to doctors a much wider array of treatment options by matching the characteristics of a patient’s tumor (54,000 molecular data points, 22,000 genes) with therapies known to target the tumor’s unique molecular make-up.

“We align the knowledge of 305 drugs against the molecular profile of the patient’s disease to find what drugs make the most evidence-based sense for that patient,” says Jerry Callahan, vice president of business development at the Van Andel Institute and chairman of Intervention Insights.

Delphinus Medical Technologies, Inc.

expression profiling at

“We can test any kind of tissue sample or cell type to help sponsors determine which genes are turned on or off by a given condition.”

Genemarkers helps clients in the personal care industry understand how skin reacts on a molecular level to environmental conditions, and to validate the efficacy and substantiate claims for sunscreens and anti-aging products.

The company also studies genetic “signposts” of nutraceuticals — antioxidant-rich blueberries, — for their effect on cells, tissues, and diseases.

Langerveld believes Genemarkers, which is pursuing Federal Clinical Laboratory Improvement Amendments (CLIA) certification, will be well positioned to respond to the demand for genomics expertise from the Kalamazoo life science community and the Western Michigan University medical school that is scheduled to open in 2014. “CLIA certification would enable Genemarkers to support clinical trials and biomarker discovery projects,” she says.

“We present all the information that’s relevant within that patient’s tumor and all the aligned drugs in the public literature so the doctor can say, ‘I’m comfortable giving this patient this drug.’”

With $3 million of initial investment, Intervention Insights began to serve clients in 2010, using the XenoBase bioinformatics platform developed by the Van Andel Institute to sift through mountains of data to detect patterns and trends. Callahan expects a current round of fundraising to fetch another $7 million by year-end.

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reliable ultrasound technology.

“Delphinus” is the Latin word for dolphin, which communicates with the aid of underwater acoustic signals. Delphinus Medical Technologies, Inc. of Plymouth, MI is a small company with big plans to revolutionize breast cancer screening, also using properties of sound.

Delphinus, which was launched in May 2010 as a spin-off of the Barbara Ann Karmanos Cancer Center, says its SoftVue imaging system is a safe and comfortable alternative to current methods of screening for breast cancer, assessing breast cancer risk, and diagnosing breast diseases.

Combining ultrasound technology and computer algorithms, SoftVue produces a three-dimensional reconstruction of the breast while it is submerged in warm water and surrounded by a transducer array ring. The need for radiation or uncomfortable compressing is eliminated.

“We believe the product has substantial advantages over mammography,” says William C. Greenway, CEO of Delphinus Medical Technologies.“Traditional ultrasound can see masses quite well, but it can’t really interrogate those masses. Our technology...or density, which is highly correlated to whether or not the tissue is cancerous.” Early clinical trials have shown SoftVue to have a positive predictive value of over 80 percent compared to 50-60 percent for mammography and ultrasound.

The first commercial-ready SoftVue unit is scheduled to reach clinical research partners in early 2012. Greenway’s goal is to ultimately capture 15-20 percent of the multi-billion dollar global breast imaging market.

BioMatters | Spring 2011

WORKFORCE DEVELOPMENT

A Strong Pipeline Feeds Michigan’s Wealth of Bio Talent

by David Bardallis The strength of any industry is in its people, and Michigan’s bioscience industry is no exception. Thanks in large part to the comprehensive academic and professional development programs throughout the state’s universities, research institutes, and community colleges, a highly educated and skilled workforce continues to develop to support the growing bioscience sector.

The University Research Corridor (URC), an alliance of Michigan’s three largest academic institutions (Michigan State University, the University of Michigan, and Wayne State University), is collectively responsible for more than 95% of research generated in the state and offers a wide range of education and outreach programs in the life sciences. According to the URC, Michigan’s research universities award more than 2,600 M.D. and advanced bio-science degrees each year and conduct more than $1 billion in life science R&D. The University of Michigan is home to the Life Sciences Institute (LSI), where “an important part of our mission is to educate and train students who will go on in the biosciences in Michigan or elsewhere,” according to Liz Barry, LSI’s managing director.

More than 100 undergraduate and graduate students experience interdisciplinary research opportunities at LSI under faculty representing fields such as cell and developmental biology, human genetics, physiology, bioinformatics, public health, and more. Through LSI’s Center for Chemical Genomics, students can even gain exposure to the early stage drug discovery process, conducting the kind of highthroughput screening that until recently was done only by industry.

According to the URC, Michigan’s research universities award more than 2,600 M.D. and advanced bio-science degrees each year and conduct more than $1 billion in life science R&D.

Each summer, LSI offers Perrigo Undergraduate Fellowships to 6-8 students from colleges and universities around the state. This innovative program is funded by the Perrigo Company, a major manufacturer of generic over-the-counter drugs based in Allegan, and aims to cultivate and retain Michigan’s top scientific talent. For 10 weeks, fellowship students are mentored by, and work in labs with, some of LSI’s 400 scientific staff members. To date, nearly 40 students

BioMatters | Spring 2011

32

have completed fellowships and gone on to pursuits in pharmacology, emergency medicine, dentistry, and other bioscience fields.

“LSI is an attractive place for students because our faculty is at the top of their fields,” says Barry. “With the open and collaborative atmosphere here, students often end up working with several faculty labs from different fields – it’s good preparation for working in the bioscience industry, where they will have to work in multidisciplinary teams.”

Bio-Education at Smaller State Colleges Michigan Technological University (MTU), in Houghton, also takes an interdisciplinary approach through its Biotechnology Research Center (BRC), where more than 90 graduate students are conducting hands-on research in fields including biomedical engineering, pharmaceutical chemistry, exercise science, and forest molecular genetics. The center’s 37 faculty members mentor and encourage nearly 100 undergraduates.

“The goal of the center is to bring faculty and students together from the different departments and push the envelope in terms of integrated approaches to the biosciences,” says Jason Carter, chair of MTU’s department of exercise science, health, and physical education.

Although traditionally known as an engineering college, MTU’s commitment to biotechnology research fits in well with its mission of providing a solid technological grounding for students, according to Carter, and its programs continue to grow.

“We’ve added eight faculty members in just the past two years as part of our health sciences initiative,” says Carter. “It’s at the point now where we’re talking about creating a separate institute out of the BRC. “In Michigan, the auto industry has always dominated, but we’ve amassed a nice piece of the biotechnology sector,” he adds. “If we want Michigan to grow in dynamic areas, biotechnology is a great opportunity.”

Ferris State University in Big Rapids has offered a four-year biotechnology degree since 1988, but has kept the program small – around 50 students – intentionally.

“Our students and grads are incredibly prepared – employers say they match up favorably with those from larger, more well-known schools,” says Isler. “Our students are 50-50 on going on to grad school or joining the workforce, but the overwhelming majority of them want to stay in-state.”

An Undergraduate Fellowship program at the University of Michigan’s Life Science Institute is funded by generics giant, Perrigo.

“Not being one of the big three research schools in the state, we do have the ability to offer smaller class sizes, smaller lab sizes, and a more focused environment,” says Bradley Isler, assistant professor of biology and coordinator of Ferris’s biotechnology program.

“In Michigan, the auto industry has always dominated, but we’ve amassed a nice piece of the biotechnology sector...”

But smaller doesn’t mean second-rate.

Ferris’s biotechnology degree includes two years in the biology program followed by a third and fourth year of core biotech courses taught at a graduate level, including microbiology and immunology, biochemistry, molecular genetics, and bioinformatics. Students also gain hands-on laboratory experience and have opportunities for internships in academia, government research agencies, or firms including Neogen in Lansing, Amway (Nutrilite) in Grand Rapids, and biotech startups in Ann Arbor and other Michigan cities.

“Our students are 50-50 on going on to grad school or joining the workforce, but the overwhelming majority of them want to stay in-state.”

Ferris’s program has been successfully graduating students with a sound foundation in the biosciences and a desire to continue their academic or professional careers in Michigan.

33

The Van Andel Institute: Teaching the Scientists of Tomorrow – And Today Four-year state universities are not the only institutions providing bioscience education in the state. The non-profit Van Andel Institute in Grand Rapids offers a vast array of educational initiatives and opportunities that run the gamut from the elementary to postdoctoral levels through its Van Andel Education Institute (VAEI) and Van Andel Research Institute (VARI).

VAEI’s Science Academy sponsors programs that teach elementary and middle school students to “think and act like scientists” as well as provide their teachers with professional development opportunities. Through the academy’s Partners for Sustainable Innovation, teachers, business leaders, and VAEI researchers meet to learn how curricula can be improved to reflect the realities of today’s bioscience industry.

For high school students, the Grand Rapids Area Pre-College Engineering Program is an opportunity to work in a laboratory while learning research methods and workplace skills.

“Our philosophy is that youngsters will be inspired to pursue science-related careers if we let them do science, not just learn about science,” says VAEI Director Steven Triezenberg. “The payoff will have tremendous benefit to their own lives and to the roles they will play in society, even if those roles ultimately are not in science-related careers.”

VARI’s programs focus on internships and opportunities for college students from the undergrad to grad levels. For the latter, the VAI Graduate School offers a Ph.D. program that teaches core concepts in biochemistry, cell biology, genetics, bioinformatics, and pathophysiology in preparation for a career in disease research. Postdoctoral fellowships at VARI are also available for scientists just starting their research careers.

BioMatters | Spring 2011

workforce development

Incentives Matter: Economic Development Agencies Work to Attract and Retain Bioscience Jobs and Talent

Amy Cell

A welcoming economic environment

is one of the keys to fostering a vibrant

in Detroit (see story page 19), companies have access to THRIVE, a

workforce and business climate in Michigan.

program that assists targeted tech startups at critical stages in their

Economic development organizations at the

development, from feasibility studies to fundraising strategies to

state, regional, and local levels all play a

business launch. With funding from the New Economy Initiative,

role in attracting and retaining companies,

a consortium of philanthropic foundations, TechTown is also part of

jobs, and talent in the biosciences and other

a three-year, $9.25 million program to provide even more training

emerging technological industries, enabling

and resources to Detroit-area entrepreneurs.

At TechTown, the 43-acre research and technology park located

Michigan to boast the fourth-largest high-

tech workforce in the nation.

tives designed to expand and diversify the local economy, making

At the state government level, the Michigan Economic Development

Just north of Detroit, Oakland County offers a range of initia-

the county a true high-tech hub. Its Emerging Sectors initiative, for

Corporation (MEDC) is working to link companies interested in locating

example, has helped recruit or retain roughly 70 companies in such

to or remaining in Michigan with local resources that can help them

areas as medical device manufacturing, robotics, nanotechnology, and

succeed even amidst the current challenging economic conditions.

information technology through tax incentives, financing, site location assistance, and more. Started in 2008, “Medical Main Street,”

MEDC is working to link companies interested in locating to or remaining in Michigan with local resources that can help them succeed even amidst the current challenging economic conditions.

an alliance of area hospitals, universities, healthcare businesses, and medical professionals, has helped generate $60 million in investment and over 1,300 new jobs, according to Irene Spanos, senior business development representative for the county. All told, Oakland County boasts more than 4,300 life science and medical facilities with more than 93,000 jobs in the sector, she said.

According to Amy Cell, MEDC’s senior vice president for talent en-

hancement, “We provide a suite of programs to help attract, develop,

“From nanomaterials to stem cell therapies to cures for diseases like childhood diabetes, I believe we’re going to see some amazing technologies coming out of Oakland County and Metro Detroit in the years ahead.”

and retain businesses and workers who contribute to Michigan’s evergrowing technological sector.”

For example, the MEDC organizes regional job fairs and operates

MichAgain.org, a website aimed at expatriated Michigan professionals that showcases the opportunities available for those wishing to come back and continue their careers in the mitten state. The site includes events and job portals that connect qualified job-seeking candidates with employers at a roughly 70 percent success rate.

The MEDC also sponsors “Shifting Gears,” a transition program

aimed at corporate professionals who want to retool their skill sets and pursue new opportunities in growing business sectors — such as biotechnology — outside of their existing career paths. Eighty percent of participants successfully land jobs in their new fields within a year.

“We have a fabulous workforce and the state is committed to bringing companies here and supporting them through our programs in talent attraction and development.”

“The future in Michigan is great,” adds Cell. “We have a fabulous

workforce and the state is committed to bringing companies here and supporting them through our programs in talent attraction and development as well as a good tax structure and a commitment to making Michigan as business friendly a climate as possible.”

BioMatters | Fall 2010

30

Patti Sekulidis, Henry Ford Community College

WORKFORCE DEVELOPMENT

“From nanomaterials to stem cell therapies to cures for

diseases like childhood diabetes, I believe we’re going to see some amazing technologies coming out of Oakland County and Metro Detroit in the years ahead,” says Spanos.

photo credit

SWMF partners with the Monroe-Brown Foundation to sponsor the state’s largest internship program geared toward retaining college students, 75 percent of whom do stay and work in Michigan after graduation.

About

Henry Ford Community College students attend classes for retraining Biotechnology certification programs and associates degrees are number of Michigan community colleges.

half of

and skills updating. offered at a

Community Colleges: Partners in Workforce Development

On the west side of the state, Kalamazoo’s Southwest Michigan First (SWMF) pursues an “integrated” model of economic

Many research lab and production jobs can be done by associatelevel technicians, and several Michigan community colleges offer this kind of training, as well as associate’s degree and certification programs for students and professionals who want to enhance or update their job skills. For example, Kalamazoo Community College and Schoolcraft

development, according to CEO Ron Kitchens, bringing together educational, philanthropic, and business programs and organizations to create what he calls “community capitalism” in a talentrich region shaken up by years of big pharma mergers and layoffs.

For example, SWMF partners with the Monroe-Brown Founda-

tion to sponsor the state’s largest internship program geared to-

“Our philosophy is that youngsters will be inspired to pursue science-related careers if we let them do science, not just learn about science...”

ward retaining college students, 75 percent of whom do stay and work in Michigan after graduation. Through its Life Science Fund and other capital initiatives, SWMF has also invested more than $150 million in roughly 70 companies, resulting in the creation of 4,000 new jobs.

College offer programs in biotech skill development, while Lansing, Oakland, and Henry Ford community colleges offer associate’s degree programs in molecular biotechnology.

Henry Ford, in fact, offers a number of options – developed in consultation with area industry leaders – for traditional students and those seeking professional development.

“About half of our students already have a degree and are coming for retraining or updating of their skills,” says Charles Jacobs, Ph.D., associate dean of science.

Two associate’s degree programs in pre-professional biology and pre-pharmacy each have about 300 students, many of whom transfer to four-year schools and grad programs. In addition, Henry Ford offers a certificate program for already-degreed individuals studying to become molecular biotechnology technicians; courses in workplace skills, nucleic acids and proteins, and laboratory instrumentation prepare them for a range of positions. Optionally, students seeking an associate’s in biotechnology receive the certification training plus take courses in statistics, ethics, chemistry, and molecular and cellular biology and complete an internship.

“Michigan, and Southeast Michigan in particular, with its major universities and colleges, produces a great number of highly competent bachelor’s, master’s, and Ph.D. scientists,” says Jacobs. “With the addition of biotech technician programs such as ours, we’re providing the whole range of workers necessary for a successful biotechnology industry.”

“It’s really an illustration of our motto that the best social program in the world is a well paying job.”

“Nobody would intentionally have the ‘creative destruction’

we’ve seen, but now we have a more diversified workforce and economy and all the new companies are thriving on the talent available here,” says Kitchens. “It’s really an illustration of our motto that the best social program in the world is a well paying job.”

35

BioMatters | Spring 2011

G uest O pinion

Tanya Schuitmaker

Rebekah Warren

Gail Haines

Roy Schmidt

My Opinion

The Bio-Industry — An Indisputable and Essential Economic Driver for Michigan

BioMatters | Spring 2011

By State Senators Tanya Schuitmaker and Rebekah Warren; State Representatives Gail Haines and Roy Schmidt Co-Chairs, Biosciences Legislative Caucus The biosciences industry in Michigan is “big business”. Over 37,000 direct jobs and a total employment impact of approximately 140,000 translates into $9.5 billion to the state’s GDP, $2.5 billion in private payroll and over $500,000 million in tax revenues.

Michigan is home to the pharmaceutical giant, Pfizer, large medical device manufacturers such as Stryker and Terumo, the world’s largest manufacturer of store-brand OTC drugs, Perrigo, and other industry leaders like Neogen, Emergent Biosolutions, Amway, Kellogg, and Dow Chemical. The state’s over 550 bio-companies represent a diverse set of industry subsectors including ag-bio, industrial biotech and chemicals, pharmaceuticals, medical devices, diagnostics, research products, medical and laboratory testing, informatics and clinical trials research. All this, coupled with great academic research centers at universities like Michigan, Michigan State, Wayne State, Oakland, Western Michigan and Michigan Tech, and eight other such public schools, as well as a host of private higher education and research institutions, like the Van Andel Institute, and a significant network of community colleges that host bioscience training programs, reflects Michigan’s commitment to our bio-industry.

It is essential that Michigan keep its focus on efforts to grow and sustain bioscience industry development. The biosciences continue to be a high-growth, high-value sector.

Michigan invested approximately $325 million of its former Life Sciences Corridor Fund and current 21st Century Jobs Fund into the biosciences sector over the last decade in support of emerging bio-company growth. In addition, our Michigan Venture Fund I, and recently launched Fund II, along with the Michigan Angel Investor Tax Credit and Pre-Seed Capital Fund, are state initiatives implemented to spur entrepreneurial ventures and commercialization of novel bioscience discoveries into real healthcare treatments.

Michigan’s Biosciences Legislative Caucus (BLC) understands the new global dynamic of increased competition for developing the biosciences industry. We are working actively to promote and grow the industry within the state. The Michigan BLC recognizes informative and inclusive discourse as a tool to formulate potential legislative initiatives. By allowing the biosciences community to integrate with the legislative process we can collectively impact policies and programs, and help make the state a leader in the global bio-economy.

Our partners in MichBio have been a great resource for the Caucus. They played a significant role in the formation of legislative committees exclusively focused on the bio-industry in both the State House and Senate, the first and only state to do so. Moreover, MichBio helped gather testimony from industry leaders at committee hearings and compiled it into a Biosciences Action Plan for state legislators to better understand the needs, challenges and opportunities for Michigan’s bio-industry.

The time for action is now and the Michigan Biosciences Legislative Caucus is committed to working with our legislative colleagues, biosciences community and economic development groups to insure that the bio-industry remains a key driver for the state’s economy, now and well into the future.

36

BioMatters J U N E 2 011

Michigan Biosciences 2011 DIRECTORY and RESOURCE GUIDE MichBio is pleased to provide the 2011 Michigan Biosciences Directory and Resource Guide, the most comprehensive listing of the state’s biosciences companies and organizations.

The complete directory, which includes the information here plus company contacts, email addresses, profiles, and listings by sector and county, is available at www.michbio.org.

Please Note: Information contained in the Michigan Biosciences Directory and Resource Guide is as current as possible. All attempts were made to validate information submitted by companies and to update existing records in MichBio’s database. If your company or organization is not listed, and you believe it should be, please visit the MichBio website (www.michbio.org) and register your company.

Direct questions to MichBio to info@michbio.org or 734.527.9150.

37

BioMatters | Spring 2011

Abundant Resources Help Ideas Become

Life-Changing Realities General Resources MichBio is the statewide association committed to building Michigan’s biosciences industry into a strong growth engine for the state’s economy.

Its members are biosciences companies, academic and research institutions, bioscience service providers, and manufacturing suppliers, economic development groups, and other related organizations. MichBio is dedicated to fostering their collective impact by connecting its members with essential resources – goods, services, educational and networking programs, policy and legislative advocacy, and partners that facilitate success. www.michbio.org (734) 527-9150 MichBio Career Center is a job bank resource matching talented life sciences professionals with fulfilling positions in the state through an online talent search mechanism. www.michbio.org/careers (734) 527-9150 Great Lakes Entrepreneur’s Quest (GLEQ) helps Michigan entrepreneurs build high-growth, new economy business ideas into successful ventures by linking them to a statewide network of resources, expert advice, education and capital. Twice a year, GLEQ hosts a statewide business plan competition with cash prizes, media exposure and business development services. www.gleq.org (734) 527-9151

BioMatters | Spring 2011

Michigan Economic Development Corporation (MEDC) is the state’s onestop resource for businesses seeking to grow in Michigan. Created through cooperation between state and local governments, the MEDC works with local communities and businesses to retain and expand job opportunities and improve Michigan’s overall business climate. www.michiganadvantage.org (888) 522-0103 Michigan Small Business & Technology Development Center (SBTDC) provides counseling, training, research and advocacy for new ventures, existing small businesses and innovative technology companies. Headquartered at Grand Valley State University, the SBTDC supports 12 regional offices and over 30 satellite offices in the state. www.gvsu.edu/misbtdc (616) 331-7480 New Enterprise Forum links entrepreneurs with management expertise, joint venture partners, business services, capital, and other critical resources. www.newenterpriseforum.org (734) 665-4433 Small Business Association of Michigan helps Michigan small businesses succeed by promoting entrepreneurship, leveraging buying power and engaging in political advocacy. www.sbam.org (800) 362-5461

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centers OF excellence Biosciences Research and Commercialization Center of Western Michigan University is a commercially focused and science driven translational research center that dedicates its pharmaceutical expertise and resources to the commercialization of promising bioscience discoveries and the growth of Michigan’s bioscience business sector. www.brcc.wmich.edu (269) 544-1072 Michigan Animal Models Consortium (MAMC) provides services associated with the development, analysis and maintenance of mouse models of human disease. The consortium combines the technological, IP expertise and facility resources at the AAALAC-accredited Van Andel Institute (VAI). The MAMC provides efficient and cost-effective animal modeling services. www.via.org/Research/Services/mamc.aspx (616) 234-5684 Michigan Antibody Technologies Center (MATC) consists of the Monoclonal Antibody Technology Core at the VAI and the Hybridoma Core at the University of Michigan (U-M). The MATC has extensive capabilities in the generation, characterization, scale-up and purification of mAbs and fragments. www.vai.org/Research/Labs/AntibodyTechnology.aspx (616) 234-5342

D I R E C TO RY & R E S O U R C E G U I D E

Michigan Biological Imaging Center (MBIC) provides comprehensive scientific/ technical imaging expertise including drug safety and efficacy data to pharmaceutical industry clients. http://homepages.wmich.edu/~eversole (269) 387-5640 Michigan Center for Bioscience Commercialization (MCBC) is a contract research and development organization located at the BRCC. The MCBC provides scientific, medical and regulatory consultation to aid in the development and commercialization of pharmaceutical, diagnostic and medical device discoveries. www.brcc.wmich.edu (269) 544-1072 Michigan Center for Structural Biology (MCSB) is designed to provide state-of-theart instrumentation and support in the area of macro-molecular structure/function determination for drug discovery. This includes x-ray crystallography, NMR spectroscopy, EPR spectroscopy, single molecular spectroscopy, protein expression and production and macromolecular structure, synthesis and sequencing. The MCSB is partnered with and utilizes beamline resources at the Argonne National Labs. http://mcsb.bch.msu.edu (517) 355-0199 Michigan High-Throughput Screening Center (MHTSC) is a contract research facility providing services in assay development and optimization and high throughput screening. Staffed by pharmaceutical industry scientists with drug discovery and HTS experience, the MHTSC offers screening of a 100,000+ compound library for a broad range of therapeutic targets with the client retaining IP rights to compounds identified in the screenings. http://mhtsc.kvcc.edu (269) 353-1582

NIH National Center for Integrative Biomedical Informatics (NCIBI) is one of seven National Centers for Biomedical Computing (NCBC) within the NIH Roadmap, which is focused on building a universal computing infrastructure designed to speed progress in biomedical research. http://portal.ncibi.org/gateway/index.html (734) 998-8564

Michigan Pre-Seed Capital Fund supports high-tech start-up companies as they near commercial viability by providing access to early-stage capital to accelerate company development. These funds extend the personal investment of entrepreneurs during the critical stage when they are developing their businesses to the point of readiness for outside investment. Information is available from local SmartZones or www.AnnArborUSA.org (734) 761-9317 SM

Wayne State University Applied Genomic Technologies (MCGT) provides oligonucleotide genechip microarrays, custom cDNA microarrays, and other genomic technology services on a fee-basis. State-of-theart equipment and a full suite of molecular genomic tools for processing and analysis means an integrated offering for gene expression profiling and HTS data mining. www.bioinformatics.wayne.edu/MCGT (313) 577-3555

Michigan-Based Funding Sources The 21st Century Jobs Fund represents a bold initiative to diversify Michigan’s economy and stimulate job creation in emerging technology sectors. After being introduced by the Governor in 2005, it received broad, bi-partisan support in the state Legislature. Using tobacco settlement dollars, it has already invested $156 million in over 95 commercialization projects in the life sciences, advanced manufacturing, alternative energy, and homeland security/defense sectors through business plan competitions.

In addition, the 21st Century Jobs Investment Fund was deployed to invest $109 million in venture capital and private equity funds. To date nearly $75 million has been invested and has attracted significant fund management activity to Michigan, providing Michigan entrepreneurs access to more diverse capital. www.michiganadvantage.org/21 (888) 522-0103

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Venture Michigan Fund is a $95 million venture capital investment program formed under the Michigan Early Stage Venture Investment Act of 2003 to promote Michigan’s economic health by assisting in the creation of jobs, new businesses and new industries within the state. The VMF makes investments ONLY in venture firms that invest primarily in Michigan-based early stage companies. www.venturemichigan.com (248) 619-1868 Federal Funding Opportunities are listed in the SSTI Weekly Funding Supplement offered by the federal government, foundations and other industries. www.ssti.org/Digest/supplement.htm (614) 901-1690

BioMatters | Spring 2011

D I R E C TO RY & R E S O U R C E G U I D E

Michigan Bio-focused Venture and Angel Groups

TGap Ventures www.tgapventures.com

Ann Arbor Angels www.annarborangels.org

Triathlon Medical Ventures www.tmvp.com

Apjohn Group, LLC www.apjohnventures.com

Venture Investors www.ventureinvestors.com

Arboretum Ventures www.arboretumvc.com

Wolverine Venture Fund www.zli.bus.umich.edu/wvf

Beringea www.beringea.com BioStar Ventures www.biostarfund.com Capital Community Angels www.capitalcommunityangels.org Dow Venture Capital www.dow.com/venture Early Stage Partners www.esplp.com EDF Ventures www.edfvc.com First Angels www.southwestmichiganfirst.com/First_Angels.cfm Fletcher Spaght Ventures www.fletcherspaght.com/ventures Grand Angels www.grandangels.org Great Lakes Angels www.glangels.org Hopen Life Science Ventures www.hopentherapeutics.com Michigan Accelerator Fund 1 www.maf-1.com Michigan Venture Capital Association www.michiganvca.org Midwest Venture Partners www.midwestvp.com North Coast Technology Investors www.northcoastvc.com Plymouth Management Company www.plymouthvc.com Seneca Partners www.senecapartners.com Southwest Michigan First Life Science Fund www.southwestmichiganfirst.com

BioMatters | Spring 2011

University Research and Technology Transfer Michigan Initiative for Innovation and Entrepreneurship The Michigan Initiative for Innovation & Entrepreneurship (MIIE) builds on Michigan’s universities as economic assets by speeding the commercialization of university research while promoting a culture of entrepreneurial risk-taking. The initiative partners Michigan’s philanthropic resources with university and private business resources to help launch new startup companies, and strengthen ties between small business, industry and academia. www.pcsum.org/aboutthecouncil/ partnerships/miie (734) 647-5730 Michigan Universities Commercialization Initiative (MUCI) complements and enhances technology transfer functions at Michigan academic and research institutions by supporting commercialization of intellectual property. www.muci.org Technology Transfer Offices: l Central Michigan University www.orsp.cmich.edu (989) 774-4000 l Eastern Michigan University www.ord.emich.edu (734) 487-3090 l Ferris State University www.ferris.edu (231) 591-2340 l Grand Valley State University www.gvsu.edu/research_dev (616) 331-2281

40

l Lake Superior State University www.lssu.edu/eng/pdc/index.php (906) 635-2738 l Lawrence Technological University www.ltu.edu/entrepreneurship/partner ship_opportunities.asp (248) 204-2310 l Michigan State University www.msu.edu/research/index.html (517) 355-2186 l Michigan Technological University www.admin.mtu.edu (906) 487-1885 l Northern Michigan University http://webb.nmu.edu/Departments/TOS (906) 227-1000 l Oakland University www2.oakland.edu/research (248) 370-2100 l Saginaw Valley State University www.svsu.edu/cbed (989) 964-4000 l University of Michigan www.techtransfer.umich.edu (734) 763-0614 l Van Andel Research Institute www.vai.org (616) 234-5000 l Wayne State University www.techtransfer.wayne.edu (313) 483-1345 l Western Michigan University www.brcc.wmich.edu (269) 544-1072 University Research Corridor is an alliance between Michigan’s three major research universities to transform, strengthen and diversify the state’s economy. The partners, Michigan State University, the University of Michigan and Wayne State University, spark regional economic development via invention, innovation and technology transfer, by educating a work force prepared for the knowledge economy, and by attracting smart and talented people to Michigan. www.urcmich.org (517) 999-4007

D I R E C TO RY & R E S O U R C E G U I D E

SmartZonesSM and Business Accelerators SmartZones provide distinct geographical locations where technology-based firms, entrepreneurs and researchers locate in close proximity to all of the community assets that assist in their endeavors. SmartZone technology clusters promote resource collaborations between universities, industry, research organizations, government and other community institutions, growing technologybased businesses and jobs. New and emerging businesses in SmartZone technology clusters are primarily focused on commercializing ideas, patents and other opportunities surrounding corporate, university or private research institute R&D efforts. www.michigan.org/smartzones SM

SM

SM

l Ann Arbor/Ypsilanti: Ann Arbor SPARK, University of Michigan, Eastern Michigan University 201 S. Division St., Ste. 430 Ann Arbor, MI 48104 (734) 761-9317 www.AnnArborUSA.org Contact: Paul Krutko l Automation Alley Lawrence Institute of Technology, Oakland University Automation Alley Technology Center 2675 Bellingham Rd. Troy, MI 48083 (248) 457-3200 www.automationalley.com Contact: Tom Anderson l Battle Creek Unlimited Western Michigan University, Kellogg Community College 4950 W. Dickman Rd. Battle Creek, MI 49037 (269) 962-7526 www.bcunlimited.org Contact: Karl Dehn

l Detroit/Woodward Technology Corridor: TechTown Wayne State University 440 Burroughs, Entrepreneurial Suite Detroit, MI 48202 (313) 879-5250 www.techtownwsu.org Contact: Randal Charlton l Grand Rapids: West Michigan Science & Technology Initiative Grand Valley State University, Van Andel Institute 301 Michigan St. NE, Ste. 536 Grand Rapids, MI 49503 (616) 331-5840 www.wmsti.org Contact: Rich Cook l Houghton/Hancock: Michigan Tech Enterprise Corporation Michigan Technological University Advance Technology Development Complex 101 West Lakeshore Drive Houghton, MI 49931 (906) 487-7000 www.mtecsmart.com Contact: Carlton K. Crothers l Jackson Technology Park Baker College, Jackson Community College, Spring Arbor University One Jackson Square, Ste. 1100 Jackson, MI 49201 (517) 788-4455 www.enterprisegroup.org Contact: Scott Fleming l Kalamazoo: WMU Business Technology & Research Park Western Michigan University 4717 Campus Drive, #100 Kalamazoo, MI 49008 (269) 353-1823 www.kazoosmic.com Contact: Robert DeWit

41

l Lansing/East Lansing: University Corporate Research Park 2727 Alliance Dr., Ste. C Lansing, MI 48910 (517) 432-1753 ucrp.msu.edu Contact: Rhonda Davis l Macomb INCubator Oakland University 7205 Sterling Ponds Ct. Sterling Heights, MI 48312 (586) 463-2542 www4.oakland.edu/macombouinc Contact: Mary Otto l Midland: Mt. Pleasant SmartZoneTM Satellite MidMichigan Innovation Center 4520 E. Ashman Rd., Ste. M Midland, MI 48642 (989) 839-2333 www.midmichiganinnovationcenter.org Contact: Chris Moultrup l Mt. Pleasant: Center for Applied Research & Technology Central Michigan University 2625 Denison Dr. Mt. Pleasant, MI 48858 (989) 774-2424 www.cmurc.com l Muskegon Lakeshore Grand Valley State University 380 W. Western Ave., Ste. 202 Muskegon, MI 49440 (231) 724-6702 www.muskegonareafirst.org Contact: Ed Garner l Rochester Hills: Oakland University INCubator Oakland University Shotwell-Gustafson Pavilion, Oakland University 2200 N. Squirrel Rd. Rochester, MI 48309 (248) 648-4800 www.oakland.edu/ouinc Contact: David Spencer

BioMatters | Spring 2011

D I R E C TO RY & R E S O U R C E G U I D E

l Michigan Research Institute 401 W. Morgan Rd. Ann Arbor, MI 48108 (734) 756-6331 www.michresearch.org Contact: Jim Richter

l Sault St. Marie Economic Development Corp.

1301 W. Easterday Ave. Sault Ste. Marie, MI 49783 (906) 635-2738 www.saultedc.com Contact: Eric Becks l Wayne County: Pinnacle Aeropark University of Michigan, Wayne State University, Detroit Metropolitan Airport 600 Randolph St., Third Floor Detroit, MI 48226 (313) 224-0752 www.waynecounty.com Contact: Dave Tyler

Allegan www.allegancounty.org

l Device and Diagnostic Accelerator, LLC 38955 Hills Tech Dr. Farmington Hills, MI 48331 (248) 536-0813 http://lifeline-ventures.com/ Contact: Ken Massey

Bay www.baycounty-mi.gov/EACD/EconomicDevelopment.aspx Benzie www.benziecountyedc.com

Great Lakes Stem Cell Innovation Center TechOne Ste. 520, 440 Burroughs Detroit, MI 48202 (313) 405-7705 www.stemcellcommercializationcenter.org Contact: James Eliason

l Michigan Center for Regenerative Medicine 401 W. Morgan Rd. Ann Arbor, MI 48108 (248) 756-6331 Contact: Jim Richter l

Michigan Life Ventures 3605 Tanglewood Dr. Ann Arbor, MI 48105 (734) 769-5447 Contact: Charles Bisgaier

Selected Michigan County Economic Development Organizations Alcona www.alconacountymi.com

Private BIOScience Incubators/Business Accelerators

l

l Vo2 Ventures 29100 Northwestern Hwy., Ste. 110 Southfield, MI 48034 (248) 358-3956 www.vo2ventures.com Contact: Greig Davis

Berrien www.berriencounty.org Calhoun www.calhouncountymi.org Genesee www.thegrcc.org Houghton www.houghtoncounty.net Ingham www.ingham.org/DV/developm.htm Ionia www.icea-mi.org

Jackson www.co.jackson.mi.us Kalamazoo www.southwestmichiganfirst.com Kent www.rightplace.org

Marquette www.marquette.org/economic-development Macomb www.macombcountymi.gov/MCPED Mason www.masoncountygrowth.com Midland www.midlandtomorrow.org Monroe www.monroecountyidc.com Muskegon www.muskegonareafirst.org Newaygo www.ncedo.org Oakland www.oakgov.com/peds Ontonagon www.ontcoedc.com Otsego www.otsego.org/econdev.htm Ottawa www.co.ottawa.mi.us Saginaw www.saginawfuture.com Sanilac www.sanilaccounty.org Schoolcraft www.schoolcraftedc.com St. Clair www.edascc.com St. Joseph www.sjcedc.com

Van Buren www.vbco.org/econdev0003.asp Washtenaw www.AnnArborUSA.org Wayne www.waynecounty.com/edge For a complete list of Michigan economic development organizations, please visit www.ecodevdirectory.com/Michigan.htm

Leelanau www.leelanau.cc

Annual Corporate Sponsor

Lenawee www.lenawee.cc

BioMatters | Spring 2011

Manistee www.allianceforeconomicsuccess.com

Traverse Bay www.tcchamber.org

Isabella www.mmdc.org

MichBio Member

Livingston www.livingstonedc.com

42

Preferred Provider

D I R E C TO RY & R E S O U R C E G U I D E

21st Century Therapeutics, Inc. 3D Biomatrix, LLC A.M. Todd AAPharmaSyn LLC Aastrom Biosciences, Inc.

52673 Seven Oaks, Ste. 105 46701 Commerce Center Dr. 1717 Douglas Ave. 3985 Research Park Dr. 24 Frank Lloyd Wright Dr., Lobby K

Shelby Township, 48316 Plymouth, 48170 Kalamazoo, 49007 Ann Arbor, 48108 Ann Arbor, 48105

313 874-4879 734 233-3078 269 343-2603 734 213-2123 734 930-5555

N/A http://www.3d-biomatrix.com http://www.amtodd.com/flash_content.php http://www.aapharmasyn.com http://www.aastrom.com

Abbott Nutrition Abriiz Absolute Laboratories Inc. Access Business Group Access Diagnostics, Inc.

901 North Centerville Rd. 425 N. Main St. 240 W. Auburn Rd. 7575 Fulton St. East 5575 Conner Ave., Ste. 1G

Sturgis, 49091 Ann Arbor, 48104 Rochester Hills, 48307 Ada, 49335 Detroit, 48213

269 651-0787 N/A 877 343-5227 616 787-6767 313 921-2266

http://www.abbott.com http://www.abriiz.com http://www.absolutelabs.net http://www.accessbusinessgroup.com http://www.accessdiagnostics.net

Access Medical LLC

Accord Biomaterials, Inc. Accumed Systems Inc. Accuri Cytometers, Inc. Adamlab, LLC

1717 Shaffer St., #107 North Professional Bldg.

3550 W. Liberty Rd., Ste. 3 6109 Jackson Rd. 173 Parkland Plz. 55 E. Long Lake Rd., Ste. 337

Kalamazoo, 49048

269 276-0068

http://www.accessmedicaldirect.com

Ann Arbor, 48103 Ann Arbor, 48103 Ann Arbor, 48103 Troy, 48085

734 995-9089 734 930-0461 734 994-8000 248 362-9603

http://www.accordbiomaterials.com http://www.accumedsystemsinc.com http://www.AccuriCytometers.com http://www.adamlab.com

Adeona Pharmaceuticals ADS Biotechnology Advanced Photonix Inc. AEGIS Environments AFID Therapeutics Inc

3930 Varsity Dr. 5703 N. Main St., Ste. E 2925 Boardwalk 2205 Ridgewood Dr. 3900 Collins Rd., Ste. 1029

Ann Arbor, 48108 Sylvania, OH, 43560 Ann Arbor, 48104 Midland, 48642 Lansing, 48910

734 332-7800 419 570-7303 734 864-5639 800 241-9186 517 336-4641

http://www.adeonapharma.com http://www.adsbiotech.com/?page_id=2 http://www.advancedphotonix.com http://www.microbeshield.com http://www.afidtherapeutics.com

Agrium, Inc. AI Medical Devices, Inc. Air Force Inc. Akervall Technologies Albemarle Corporation

2405 Vassar Rd. 311 Turner Rd. 933 Butternut Dr. 5643 Plymouth Rd. 1421 S. Kalamazoo St.

Reese, 48757 Williamston, 48895 Holland, 49424 Ann Arbor, 48105 South Haven, 49090

989 752-2138 800 219-9561 616 399-8511 734 485-2949 269 637-8474

http://www.agrium.com http://www.aimedicaldevices.com http://www.dentalairforce.com http://www.akervalltechnologies.com http://www.albemarle.com

Algal Scientific Corporation Alivio Corporation AlixPartners Alliant Healthcare Products Alluvium Biosciences

46701 Commerce Center Dr. 20429 Honor Hwy. 2000 Town Center, Ste. 2400 8850 M-89 401 W. Morgan Rd.

Plymouth, 48170 Interlochen, 49643 Southfield, 48075 Richland, 49083 Ann Arbor, 48108

734 218-5717 231 275-1345 248 358-4420 269 629-0300 734 276-4921

http://www.algalscientific.com http://www.aliviocorp.com http://www.alixpartners.com http://www.allianthealthcare.com http://www.alluviumbio.com

AlphaCore Pharma A-L-S Technologies Inc. Altarum Institute Altus Industries American Diabetes Association

333 Parkland Plaza, Ste. 5 1740 W. Big Beaver 3520 Green Ct., Ste. 300 3731 Northridge Dr. NW, Unit 1 30300 Telegraph Rd., Ste. 117

Ann Arbor, 48103 Troy, 48084 Ann Arbor, 48105 Walker, 49544 Bingham Farms, 48025

734 527-9137 248 885-8302 734 302-4600 888 537-1311 248 433-3830

N/A http://www.als-tech.com http://www.altarum.org http://www.altus-inc.com http://www.diabetes.org

American Seating American Society for Microbiology American Society of Employers AmFab, Inc. Amgen

401 American Seating Ctr. NW 9205 Huron River Drive.

23815 Northwestern Hwy. 1446 South 35th St. 9935 N. Valley Hill Dr.

Grand Rapids, 49504 Dexter Township, 48130 Southfield, 48075 Galesburg, 49053 Mequon, WI, 53092

616 732-6600 734 845-3661 248 223-8019 269 665-6703 262 240-9961

http://www.americanseating.com http://www.mi-asm.org http://www.aseonline.org http://www.amfab.com http://www.amgen.com

Amigo Mobility International, Inc. Angott Medical Products, LLC Ann Arbor Clinical Research Ann Arbor SPARK Antel BioSystems, Inc

6693 Dixie Hwy. 442 Five Gaits Ct. 203 S. Zeeb Rd., Ste. 105 201 S. Division, Ste. 430 3655 Forest Rd.

Bridgeport, 48722 Bloomfield Hills, 48304 Ann Arbor, 48103 Ann Arbor, 48104 Lansing, 48910

989 921-5062 248 444-1492 734 926-0957 734 761-9317 800 631-3510

http://www.myamigo.com N/A http://www.annarborclinicalresearch.com http://www.AnnArborUSA.org http://www.antelbio.com

MichBio Member

Annual Corporate Sponsor

Ag-Bio/Industrial Testing

Information Technology Professional Services

Medical Device Manufacturing Suppliers

Preferred Provider Research & Development Government/Non-Profit

Pharmaceuticals Education/Clinical

For further information, please visit www.michbio.org 43

BioMatters | Spring 2011

D I R E C TO RY & R E S O U R C E G U I D E

Apjohn Group, LLC ApoLife, Inc. AquaBiochip, LLC Arbor Assays LLC Arbor Preclinical & Consulting, LLC

350 E. Michigan Ave., Ste. 500 100 River Pl., #5350 1012 N. Walnut St., Ste. 101 1514 Eisenhower Pl. 8975 South Ave. E

Kalamazoo, 49007 Detroit, 48207 Lansing, 48906 Ann Arbor, 48108 Scotts, 49088

269 349-8999 313 446-2625 517 402-2692 734 677-1774 734 330-4396

http://www.apjohngroup.com http://www.apolife.com http://www.aquabiochip.com http://www.ArborAssays.com http://www.arborpcc.com

Arbor Research Collaborative for Health Arboretum Ventures

Arcanum Corporation Arivium, Inc. Armune BioScience, Inc.

315 W. Huron St., Ste. 360

Ann Arbor, 48103

734 665-4108

http://www.arborresearch.org

Market Place Building, 303 Detroit St., Ste. 301 5340 Plymouth Dr., Ste. 101 1440 Front Ave. NW, Penthouse A 350 E. Michigan Ave., Ste. 500

Ann Arbor, 48104

734 998-3688

http://www.arboretumvc.com

Ann Abor, 48105 Grand Rapids, 49504 Kalamazoo, 49007

734 665-4421 616 292-5018 269 349-8870

N/A http://www.arivium.com http://www.armune.com

Art Optical Contact Lens, Inc. ArtJen Complexus USA Ascendant MDx, Inc. Ash Stevens ASI Instruments, Inc.

3175 3 Mile Rd. NW 440 Burroughs St., Mailbox 65 26842 Haggerty Rd. 5861 John C. Lodge Fwy. 12900 E. Ten Mile Rd.

Walker, 49534 Detroit, 48202 Farmington Hills, 48331 Detroit, 48202 Warren, 48089

616 453-1888 877 4-ARTJEN N/A 313 872-6400 586 756-1222

http://www.artoptical.com http://www.mirafit.com N/A http://www.ashstevens.com http://www.asi-instruments.com

Aspen Surgical Products, Inc. Asterand Inc. ATEK Medical Manufacturing Ateq Corporation Auburn Pharmaceutical Company

6945 Southbelt SE TechOne Bldg, 440 Burroughs, Ste. 501 620 Watson SW 35980 Industrial Dr. 1775 John R. Rd.

Caledonia, 49316 Detroit, 48202 Grand Rapids, 49504 Livonia, 48150 Troy, 48083

888 364-7004 313 263-0960 616 643-5200 734 838-3100 248 526-3750

http://www.aspensurgical.com http://www.asterand.com http://www.atekmedical.com http://www.atequsa.com http://www.auburnpharm.com

AureoGen Biosciences, Inc. Aursos, Inc Autocam Medical Automated Software Technology Automation Alley

6475 Technology Ave., Ste. C 350 E. Michigan Ave., Ste. 500 4436 Broadmoor SE 1328 Ramblewood 2675 Bellingham

Kalamazoo, 49009 Kalamazoo, 49007 Kentwood, 49512 East Lansing, 48823 Troy, 48083

269 353-3805 703 845-5429 616 541-8080 517 316-2138 248 457-3200

http://www.aureogen.com http://www.aursos.com http://www.autocam-medical.com http://www.autosofttech.net http://www.automationalley.com

AVAcore Technologies Avalon Laboratories LLC Avicenna Medical Systems, Inc. AxioBionics Axsys Technologies, Inc.

333 Parkland Plaza Dr., Ste. 700 301 Michigan St. NE, Ste. 500 3090 Dhu Varren Ct. 6111 Jackson Rd., Ste. 200 2909 Waterview Dr.

Ann Arbor, 48103 Grand Rapids, 49503 Ann Arbor, 48105 Ann Arbor, 48103 Rochester Hills, 48309

888 282-2673 616 331-5843 888 284-4080 734 327-2946 248 293-2900

http://www.avacore.com http://www.avalonlabs.com http://www.avicenna-medical.com http://www.axiobionics.com http://www.axsys.com

Azenic Dental, Inc. AzoRx, Inc. BAC Technologies, LLC Barbara Ann Karmanos Cancer Institute BarbLock

350 E. Michigan Ave., Ste. 135 4717 Campus Dr. 540 Avis Dr., Ste. A 4100 John R. Rd.,

Kalamazoo, 49007 Kalamazoo, 49008 Ann Arbor, 48103 Detroit, 48201

269 349-8870 269 760-0403 734 663-4233 800 527-6266

http://www.azenic.com http://www.azorx.com http://www.tsrlinc.com http://www.karmanos.org

11590 S. US-31

Williamsburg, 49690

231 264-0101

http://www.barblock.com

Bauer Biomedical, LLC Bayer CropScience Bayer Health Care BD - Difco Laboratories BD Diagnostics

2625 Denison Dr. 1740 N. Whitehall 6549 Braemar Ave. 920 Henry St. 5230 S. State Rd.

Mt. Pleasant, 48854 Muskegon, 49445 Noblesville, IN, 46069 Detroit, 48201 Ann Arbor, 48108

810 397-2882 231 719-3000 317 774-8069 313 442-8000 734 663-4719

N/A http://www.bayercropscience.com http://www.bayerhealth.com http://www.bd.com http://www.bd.com

Research Institute, 3811 W. 13 Mile Rd. 3601 W. Thirteen Mile Rd. 3601 W. Thirteen Mile Rd. 3601 W. Thirteen Mile Rd. 635 Executive Dr.

Royal Oak, 48073 Royal Oak, 48073 Royal Oak, 48073 Royal Oak, 48073 Troy, 48083

248 898-5000 248 551-0255 248 551-8550 248 551-8550 248 588-7480

http://www.beaumonthospitals.com/biobank http://www.beaumontcommercializationcenter.com http://www.beaumonthospitals.com http://www.beaumonthospitals.com/labs http://www.beckerorthopedic.com

Beaumont Bio Bank Beaumont Commercialization Center Beaumont Hospitals Beaumont Laboratory Becker Orthopedic

MichBio Member Ag-Bio/Industrial Testing

BioMatters | Spring 2011

Information Technology Professional Services

Annual Corporate Sponsor Medical Device Manufacturing Suppliers

Preferred Provider Research & Development Government/Non-Profit

For further information, please visit www.michbio.org 44

Pharmaceuticals Education/Clinical

D I R E C TO RY & R E S O U R C E G U I D E

Beckman Coulter Molecular Diagnostics (aka Lumigen, Inc.) Berry & Associates, Inc. Better Rehab, LLC Biddergy.com Bio Logic Engineering, Inc.

22900 W. Eight Mile Rd.

Southfield, 48033

248 351-5600

http://www.lumigen.com

2434 Bishop Circle E. 1170 Morehead Ct. 1919 E. Kilgore Service Rd. 1675 N. Lima Center Rd.

Dexter, 48130 Ann Arbor, 48104 Kalamazoo, 49002 Dexter, 48130

734 426-3787 734 604-1966 N/A 248 719-3150

http://www.berryassoc.com N/A http://www.biddergy.com http://www.biologicengineering.com

Bio-Chem Laboratories, Inc. Biogen Inc. Bio-lab, Inc., A Chemtura Company BioLumix, Inc Biomedical Diagnostics, LLC

BioMedware Inc. Biomide Bio-Nano Power, LLC Biopelle BioPharma Data Services

1049 28th St., SE 2572 Tibernyck Trail Dr. 1400 E. Michigan St. 104 Aprill Dr. 5692 Plymouth Rd., Ste. B

Grand Rapids, 49508 Troy, 48098 Adrian, 49221 Ann Arbor, 48103 Ann Arbor, 48105

616 248-4900 248 646-4791 517 265-6138 734 984-3100 888 652-4246

http://www.bio-chem.com/Home/tabid/36/Default.aspx http://www.biogen.com http://www.chemtura.com http://www.mybiolumix.com http://www.bio-diagnostics.com

3526 W. Liberty Rd., Ste. 100 21 Kercheval Ave., Ste. 330 2625 Denison Dr. 780 W. 8 Mile Rd. 1461 Scio Ridge Ct.

Ann Arbor, 48103 Grosse Pointe Farms, 48236 Mt. Pleasant, 48858 Ferndale, 48220 Ann Arbor, 48103

734 913-1098 313 886-0589 616 682-0367 866 424-6735 734 255-1038

http://www.biomedware.com N/A N/A http://www.biopelle.com http://www.BioPharmaDataServices.com

Biophotonic Solutions, Inc. Biopolymer Innovations BioPro Biosciences Research and Commercialization Center at Western Michigan University Biosol, Ltd.

1401 E. Lansing Dr., Ste. 112 16647 Chandler Rd. 2929 Lapeer Rd. 4717 Campus Dr.

East Lansing, 48823 East Lansing, 48823 Port Huron, 48060 Kalamazoo, 49008

517 580-4075 517 432-3044 810 982-7777 269 544-1072

http://www.biophotonicsolutions.com http://www.biopolymerinnovations.com http://www.bioproimplants.com http://www.brcc.wmich.edu

206 Fifth Ave.

Ann Arbor, 48104

734 663-0645

http://www.liposol.com

BioSolutions, LLC BioSTAT Consultants, Inc. Biotech Clinical Laboratories Biotechnology Business Consultants & BBCetc.

Biotectix

1811 Hayes St. #E 528 W. Centre Ave. 24469 Indoplex Cir. 803 N. Main St.

Grand Haven, 49417 Portage, 49024 Farmington Hills, 48335 Ann Arbor, 48104

616 846-1210 269 329-7976 248 426-9800 734 930-9741

http://www.biosolutionsllc.com http://www.biostat.net http://www.biotechclinical.com http://www.bioconsultants.com

940 N. Main St.

Ann Arbor, 48104

734 585-5126

http://www.biotectix.com

Biotronic NeuroNetwork Birchbrook Technologies L.L.C. Blaze Medical Devices BlueWare, Inc. Borgess Research Institute

812 Avis Dr. 53470 Andrew Cir. 9146 Dexter Pinckney Rd. 3060 W. 13th St. 1717 Shaffer, Ste. 003

Ann Arbor, 48108 New Baltimore, 48047 Pinckney, 48169 Cadillac, 49601 Kalamazoo, 49048

800 638-7564 586 648-8267 734 945-7764 231 779-0224 269 226-5407

http://www.biotronic.com http://www.birchtek.com http://www.blazemedicaldevices.com http://www.blueware.net http://www.research.borgess.com

BoroPharm, Inc. Bremer Prosthetic Design, Inc. Brenner Orthotic and Prosthetic Labs BREONICS Bridge Organics Co.

2800 Plymouth Rd., Bldg. 40 3487 S. Lindin Rd., Ste. U 32975 W. Eight Mile Rd. W.A. Harriman Tech. Campus, Bldg 7A 311 W. Washington St.

Ann Arbor, 48105 Flint, 48507 Livonia, 48152 Albany, NY, 12206 Vicksburg, 49097

517 455-7847 810 733-3375 810 615-0601 518 213-4670 269 649-4200

http://www.boropharm.com http://www.bremerprosthetics.com N/A http://www.breonics.com http://www.bridgeorganics.com

Brighton Analyticals, LLC Brio Device, LLC Brown & Brown of Detroit Bryllan, LLC Butzel Long

2105 Pless Dr. 2378 Leslie Cir. 35735 Mound Rd. 26105 Orchard Lake Rd. 350 S. Main St., Ste. 300

Brighton, 48114 Ann Arbor, 48105 Sterling Heights, 48311 Farmington Hills, 48334 Ann Arbor, 48104

810 229-7575 734 945-5728 586 977-6300 248 699-6113 734 213-3435

http://brightonanalytical.net N/A http://www.bbdetroit.com http://www.bryllan.com http://www.butzel.com

3600 Green Ct., Ste. 400 4520 E. Ashman Rd., Ste. C 1150 Elijah McCoy Dr.

Ann Arbor, 48105 Midland, 48642 Detroit, 48202

919 240-4089 989 496-3110 313 871-8400

http://www.pipetpeople.com http://www.caltechind.com http://www.caraco.com

7444 Haggerty Rd. 3991 Ramsgate Ct.

Canton, 48187 Ann Arbor, 48103

734 738-1963 N/A

http://www.cardiarc.com http://www.cardiavent.com

Calibrate, Inc. - The Pipet People Caltech Industries, Inc. Caraco Pharmaceutical Laboratories, Ltd. CardiArc Cardiavent

MichBio Member Ag-Bio/Industrial Testing

Information Technology Professional Services

Annual Corporate Sponsor Medical Device Manufacturing Suppliers

Preferred Provider Research & Development Government/Non-Profit

Pharmaceuticals Education/Clinical

For further information, please visit www.michbio.org 45

BioMatters | Spring 2011

D I R E C TO RY & R E S O U R C E G U I D E

Cascade Hemophilia Consortium Cascade Life Solutions Cayman Chemical Company CeeTox, Inc. Cell Culture Characterization Services

210 E. Huron St., Ste. D 3710 Sysco Ct., SE 1180 E. Ellsworth Rd. 4717 Campus Dr. 1872 N. Adams

Ann Arbor, 48104 Grand Rapids, 49512 Ann Arbor, 48108 Kalamazoo, 49008 Rochester Hills, 48306

734 996-3300 616 977-2515 734 971-3335 269 353-5555 248 656-2542

http://www.hemoalliance.org N/A http://www.caymanchem.com http://www.ceetox.com N/A

Cellular Biotechnology Training Program Center for Clinical Research Solutions, Inc. Center for Reproductive Medicine and Surgery Central Michigan University Central Michigan University - Center for Applied Research & Technology

1150 W. Medical Center Dr.

Ann Arbor, 48109

734 763-3533

http://www.cbtp.umich.edu

8357 Glenwynd Dr.

Kalamazoo, 49009

269 375-2915

http://www.c2rs.com

300 Park St., Ste. 460

Birmingham, 48009

248 593-6990

http://reproductive-medicine.com

Brooks Hall 2625 Denison Dr.

Mt. Pleasant, 48858 Mt. Pleasant, 48858

989 774-4000 989 774-1574

http://www.cmich.edu http://www.cmich.edu/x793.xml

Central Michigan University - Dow College of Health Professions Central Michigan University - Office of Research and Sponsored Programs Centurion Medical Products Cerenis Therapeutics Inc. Cerise Nutraceuticals, Inc.

4170 S. Meridian

Mt. Pleasant, 48858

989 774-4000

http://www.cmich.edu

251 Foust Hall

Mt. Pleasant, 48858

989 774-6777

http://www.orsp.cmich.edu

100 Centurion Way 900 Victors Way, Ste. 280 1670 Barlow St., Ste. A

Williamston, 48895 Ann Arbor, 48108 Traverse City, 49686

800 248-4058 734 769-1110 231 933-3300

http://www.centurionmp.com http://www.cerenis.com http://www.cherrylotion.com

CFI Medical Solutions (Contour Fabricators, Inc.) Charles River Chase Environmental Group, Inc. Chelon, Inc. Chemtura

14241 Fenton Rd.

Fenton, 48430

810 750-5300

http://www.cfimedical.com

9801 Shaver Rd. 1835 Timber Tr. 6450 Bridlewood Ct. 1400 E. Michigan St.

Portage, 49002 Ann Arbor, 48103 Ada, 49301 Adrian, 49221

269 327-4248 734 255-9034 616 682-0793 517 265-6138

http://www.criver.com http://www.chaseenv.com N/A http://www.chemtura.com

Children’s Hospital of Michigan 3901 Beaubien Christian Roux Ltd. 598 E. Grand Blvd.

Chubb Group of Insurance Companies 1450 W. Long Lake Rd., Ste. 210 Cielo MedSolutions 3520 Green Ct., Ste. 200 City of Marshall Economic 323 W. Michigan Development

Detroit, 48201 Ypsilanti, 48198 Troy, 48098 Ann Arbor, 48105 Marshall, 49068

888 362-2500 734 732-6671 734 741-1850 734 827-1000 269 781-5183

http://www.childrensdmc.org http://www.hurricanecrutch.com http://www.chubb.com http://www.cielomedsolutions.com http://www.cityofmarshall.com

Clear Image Devices Clinical Ligand Assay Society ClinSite, Inc. ClinXus CNVGenes LLC

3930 Michael Rd. N 29003 Balmoral St. 24 Frank Lloyd Wright Dr., Lobby A 330 Bostwick Ave., NE 4995 Arrowhead Rd.

Ann Arbor, 48103 Garden City, 48135 Ann Arbor, 48106 Grand Rapids, 49503 West Bloomfield, 48323

734 645-6459 734 722-6290 734 930-3700 616 331-5854 248 682-3368

http://www.clearimagedevices.com http://www.clas.org http://www.clinsite.com http://www.clinxus.org http://www.cnvgenes.com

Coherix, Inc. College Park Industries Compendia Bioscience Conceivex Concepts in Software

3980 Ranchero Dr. 17505 Helro Rd. 110 Miller Ave., Floor 2 5 E. Main St. 455 Woodland Hills Dr.

Ann Arbor, 48108 Fraser, 48026 Ann Arbor, 48104 Saranac, 48881 Walled Lake, 48390

734 761-8989 586 294-7950 734 929-3909 888 306-6366 734 730-4692

http://www.coherix.com http://www.college-park.com http://www.compendiabio.com http://www.conceptionkit.com http://www.conceptsinsoftware.com

Contented Hearts, Inc. Copagen Corium International, Inc. Covalent Medical, Inc. Covance Research Products

11490 East G Ave. 5528 Gallery Park Dr. 4558 50th St., SE 4750 S. State St., Ste. 301 6321 S. 6th St.

Galesburg, 49053 Ann Arbor, 48103 Grand Rapids, 49512 Ann Arbor, 48108 Kalamazoo, 49009

269 665-4420 734 904-0365 616 656-4563 734 429-2451 269 375-0482

http://www.contentedhearts.com N/A http://www.coriumintl.com http://www.covamed.com http://www.crpinc.com

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Pharmaceuticals Education/Clinical

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Coy Laboratory Products Inc. CPR Mattress Crissman Toxicologic Pathology, LLC Critech Research, Inc. Critical Signal Technologies

14500 Coy Dr. 200 Michigan St. 2887 Oakhaven Ct. 1705 Woodland Dr. E., Ste. 100 22600 Haggerty Rd.

Grass Lake, 49240 Hancock, 49930 Midland, 48642 Saline, 48176 Farmington Hills, 48335

734 475-2200 906 483-2676 989 631-2790 734 668-0005 888 557-4462

http://www.coylab.com http://www.cprmattress.com http://www.pathexperts.com http://www.critech.com http://www.criticalsignaltechnologies.com

Custom Biogenic Systems Cutting Image Histology, LLC Cybernet Medical

CytoPherx Danmar Products Inc.

150 Shafer Dr. 800 Technology Dr. Cybernet Systems Corporation, 727 Airport Blvd.

401 W. Morgan Rd. 221 Jackson Industrial Dr.

Romeo, 48065 Ann Arbor, 48108 Ann Arbor, 48108

586 331-2600 517 712-3102 800 292-3763

http://www.custombiogenics.com http://www.cuttingimagehistology.com http://www.cybernetmedical.com

Ann Arbor, 48108 Ann Arbor, 48103

734 272-4772 800 783-1998

http://www.cytopherx.com http://www.danmarproducts.com

270 Chesterfield 8031 Main St., Ste. 301 2971 Vineyards Dr. 5830 Crossroad, Commerce Pkwy.

2511 Davison Rd.

Birmingham, 48009 Dexter, 48130 Troy, 48098 Wyoming, 49519 Flint, 48506

N/A 734 426-4995 248 952-1968 616 261-9191 866 742-0581

N/A http://www.dissdata.com http://www.dataspeaks.com http://www.dentalservices.net/davis http://www.standingdani.com

789 Dixboro Rd.

Ann Arbor, 48113

734 769 8010

http://www.dba-global.com

4571 Ellsworth Rd. 99 Monroe Hudson-Webber Cancer Research Center, Rm. 504, 4100 John R. Rd. 3110 Schuette Dr.

Ypsilanti, 48197 Grand Rapids, 49503 Detroit, 48201

734 434-7734 888 332-0141 313 576-8251

http://www.ddots.com http://www.deanzafuel.com/index.htm http://www.delphinusmt.com

Midland, 48642

989 496-1152

http://www.dendritech.com

Dast Systems, LLC Data Integrated Scientific Systems DataSpeaks, Inc. Davis Dental Labs DavisMade, Inc.

DBA Analytical (an NSF International Company) DDots, Inc. DeAnza Fuel Group Delphinus Medical Technologies

Dendritech, Inc.

Dendritic Nanotechnologies, Inc. DNT Finance, 2625 Denison Dr. Mt. Pleasant, 48858 989 774-6565 http://www.dnanotech.com Dermanaut 5260 Anthony Wayne Dr. Detroit, 48202 313 202-6760 http://www.dermanaut.com Detroit Clinical Research Center 27780 Novi Rd., Stes. 100 & 230 Novi, 48377 248 825-3159 http://www.dcrc.us Detroit Medical Center-Wayne 4201 Antoine St. Detroit, 48201 313 993-8921 http://www.dmc.org/univlab/default.htm State Lab Detroit Neurosurgical Foundation 3333 E. Jefferson Ave. Detroit, 48207 313 259-0391 N/A Detroit R&D, Inc. Metropolitan Center for High Technology Detroit, 48201 313 961-1606 http://www.detroitrandd.com

(MCHT), 2727 Second Ave., Ste. 4113 Device and Diagnostic Accelerator, LLC Diagnostic Instruments Inc. Diamond General Digilab Genomic Solutions Diversified Natural Products

38955 Hills Tech Dr.

Farmington Hills, 48331

248 536-0813

N/A

6540 Burroughs St. 333 Parkland Plaza Dr. 4355 Varsity Dr., Ste. E 506 E. State St.

Sterling Heights, 48314 Ann Arbor, 48103 Ann Arbor, 48108 Scottville, 49454

586 731-6000 800 678-9856 734 975-4800 231 757-9241

http://www.diaginc.com http://www.diamondgeneral.com http://www.genomicsolutions.com http://www.dnpworld.com

DNA Software, Inc. DNADNB LLC Doeren Mayhew DRAMgene Draths Corporation

334 E. Washington St. 4995 Arrowhead Rd. 755 W. Big Beaver Rd., Ste. 2300 39 Blackburn SW 4055 English Oak Dr.

Ann Arbor, 48104 West Bloomfield, 48323 Troy, 48084 Wyoming, 49509 Lansing, 48911

734 222-9080 248 682-3368 248 244-3005 616 828-2207 517 349-0669

http://www.dnasoftware.com N/A http://www.doeren.com N/A http://www.drathscorporation.com

Drug & Laboratory Disposal, Inc. DSC Labs Ducker Worldwide DuPeron Medical Systems Dykema Gossett PLC

331 Broad St. 1979 Latimer Dr. 1250 Maplelawn 515 N. Washington Ave. 400 Renaissance Center

Plainwell, 49080 Muskegon, 49442 Troy, 48084 Saginaw, 48607 Detroit, 48243

269 685-9824 231 777-3012 248 644-0086 800 383-8479 313 568-6800

http://www.dld-inc.com http://www.dsclab.com http://www.ducker.com http://www.duperon.com http://www.dykema.com

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D I R E C TO RY & R E S O U R C E G U I D E

Eastern Michigan University

Eastern Michigan University - Center for Entrepreneurship Eastern Michigan University - Office Research Development ECO PHYSICS, INC. Ecology Health Products, Inc.

College of Arts & Sciences, 411 Pray-Harrold 559 Owen College of Business

Ypsilanti, 48197

734 487-1955

http://www.emich.edu

Ypsilanti, 48197

734 487-6516

http://www.emich.edu/public/cob/entrepreneur

Starkweather Hall, Office of Research Development 3915 Research Park, Ste. A-3 12941 E. Townline Rd.

Ypsilanti, 48197

734 487-3090

http://www.emich.edu

Ann Arbor, 48108 Goetzville, 49736

734 998-1600 866 326-7763

http://www.ecophysics-us.com http://www.ecologyproducts.com

EcoSynthetix Ecotek EdgeHealth LLC Elan Nutrition Inc. Elba Laboratories

3900 Collins Rd. 440 Burroughs St., Ste. 511 217 Third St. 4490 44th St. SE 1925 W. Maple Rd.

Lansing, 48910 Detroit, 48202 Ann Arbor, 48103 Grand Rapids, 49512 Troy, 48084

517 336-4623 313 399-7893 734 622-8060 616 940-6000 248 288-6098

http://www.ecosynthetix.com http://www.ecotek-us.com N/A http://www.elannutrition.com http://www.elba-labs.com

Elm Strategies LLC Eloquest Healthcare Elsevier Emerald BioAgriculture Corporation/ Auxein Corporation Emergent BioSolutions

2300 Melrose Ave. 780 W. Eight Mile Rd. 3675 Crestwood Pkwy., Ste. 400 2123 University Park Dr., Ste. 105

Ann Arbor, 48104 Ferndale, 48220 Duluth, GA, 30096 Okemos, 48864

734 604-2479 877 433-7626 770 935-6077 517 882-7370

N/A http://www.eloquesthealthcare.com http://www.elsevier.com http://www.emeraldbio.com

3500 Martin Luther King Jr. Blvd.

Lansing, 48906

517 327-1500

http://www.ebsi.com

Emiliem 4717 Campus Dr., Ste. 700 Kalamazoo, 49009 415 421-0222 http://www.emiliem.com Emil’s Molecular Design, LLC. 8772 Trillium Dr. Ypsilanti, 48197 N/A N/A Endra Inc 35 Research Dr. Ann Arbor, 48103 734 274-2258 http://www.endrainc.com Ennew Medical Devices, LLC 2400 N. 6th St. Kalamazoo, 49009 269 615-5113 N/A Enzo Life Sciences International, Inc. 5777 Hines Dr. Ann Arbor, 48108 734 668-6113 http://www.assaydesigns.com (formerly Assay Designs, Inc.)

Epsilon Imaging Inc. Ernst & Young LLP Esperion Therapeutics, Inc. Essen BioScience Eurofins Avtech Laboratories, Inc.

3917 Research Park Dr. 171 Monroe Ave. NW 46701 Commerce Center Dr. 300 W. Morgan Rd. 6859 Quality Way

Ann Arbor, 48108 Grand Rapids, 49503 Plymouth, 48170 Ann Arbor, 48108 Portage, 49002

734 369-5100 313 628-7100 734 862-4840 734 769-1600 269 323-3366

http://www.epsilon-imaging.com http://www.ey.com http://www.esperion.com http://www.essen-instruments.com http://www.eurofins.com

Everist Genomics, Inc. exCel Cosmeceuticals, Inc. Exponent, Inc. EXT Lifesciences, Inc. EyeLab Group

401 W. Morgan Rd. 4120 Maple Rd. 39100 Country Club Dr. 2000 Town Center 2350 Washtenaw

Ann Arbor, 48108 Bloomfield Hills, 48301 Farmington Hills, 48331 Southfield, 48075 Ann Arbor, 48104

734 929-9475 248 539-1212 248 324-9100 248 948-6910 734 665-0566

http://www.genetics2.com http://www.xlafa.com http://www.exponent.com http://www.extlifesciences.com http://www.eyelabgroup.com

e-Zassi 1886 S. 14th St. Ferndale Laboratories Inc. 780 W. Eight Mile Rd. Ferndale Pharma Group 780 W. Eight Mile Rd. Ferris State University 1201 S. State St. Ferris State University - Biotechnology 820 Campus Dr. / ASC 2004 Program/Department of Biology

Amelia Island, FL, 32034 Ferndale, 48220 Ferndale, 48220 Big Rapids, 49307 Big Rapids, 49307

904 261-6290 248 548-2422 248 548-0900 231 591-2000 231 591-2641

http://www.e-zassi.com http://www.ferndalelabs.com http://www.ferndalelabs.com http://www.ferris.edu http://catalog.ferris.edu/programs/26

Saginaw, 48604 St. Charles, 48655 Ann Arbor, 48108 Kalamazoo, 49009 West Bloomfield, 48323

989 797-3117 800 566-8569 N/A 269 375-1290 248 682-3368

http://www.fni.org http://www.filtronafibertec.com http://www.flowsensemedical.com http://www.flowtechfilters.com N/A

Field Neurosciences Institute Filtrona Porous Technologies FlowSense FlowTech Corporation Fluid Insights LLC

4677 Towne Center 5301 S. Graham Rd. 1456 Astor Dr. 7601 Stadium Dr. 4995 Arrowhead Rd.

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D I R E C TO RY & R E S O U R C E G U I D E

Forensic Fluids Laboratories Inc. 225 Parsons St. Kalamazoo, 49007 269 492-7700 http://www.forensicfluids.com Fraunhofer USA CCL B100 Eng. Research Complex East Lansing, 48824 517 432-8711 http://www.ccl.fraunhofer.org Fraunhofer USA, Center for 46025 Port St. Plymouth, 48170 734 354-6300 http://www.clt.fraunhofer.com Laser Technology (CLT) Freeman Manufacturing Company 900 W. Chicago Rd. Sturgis, 49091 269 651-2371 http://www.freemanmfg.com Fuller Compliance, LLC 5742 Springwater Ln. West Bloomfield, 48322 714 335-0248 http://www.fullercompliance.com

G2G Consulting 11000 Cedar Ave. Cleveland, OH, 44106 216 658-3995 http://g2gconsulting.com GANTEC, Inc. 4520 E. Ashman Rd. Midland, 48642 989 631-9300 http://www.gantecinc.com Garrison Dental Solutions 150 DeWitt Ln. Spring Lake, 49456 616 842-2244 http://www.garrisondental.com GE Medical Systems Information 3300 Washtenaw Ave. Ann Arbor, 48104 N/A http://www.gehealthcare.com/usen/hit/index.html Technology Gema Diagnostics 463 Rosewood Ave. East Lansing, 48823 517 775-3007 http://www.gemadiagnostics.com

Gene Codes Gene Codes Forensics, Inc. Geneflux Biosciences GeneGo, Inc. Genemarkers LLC

775 Technology Dr. 775 Technology Dr., Ste. 100A #509 55 E. Long Lake Rd. 500 Renaissance Dr. 4280 Commercial Ave.

Ann Arbor, 48108 Ann Arbor, 48108 Troy, 48085 St. Joseph, 49085 Portage, 49002

734 769-7249 734 769-7249 248 269-3755 269 983-7629 269 998-8116

http://www.genecodes.com http://www.genecodesforensics.com http://www.geneflux.co.in http://www.genego.com http://www.genemarkersllc.com

Genentech Genomatix Software, Inc. Gerber Product Company Gerontology Network Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

333 W. North Ave. 3025 Boardwalk 445 State St. 500 Cherry St. SE P.O. Box 7021

Chicago, IL, 60610 Ann Arbor, 48108 Fremont, 49413 Grand Rapids, 49503 Troy, 48007

650 225-1000 877 436-6628 231 928-2000 616 456-6135 248 647-6000

http://www.gene.com http://www.genomatix-software.com http://www.gerber.com http://www.michiganseniors.org http://www.patlaw.com

Gift of Life Michigan Giri Diagnostics LLC GlaxoSmithKline Global Clinical Connections Global Orphan Pharmaceutical, LLC

3861 Research Park Dr. 2611 Parmenter Blvd.

7890 Charline Court MTEC at the Groves at KVCC 2155 Butterfield Dr.

Ann Arbor, 48108 Royal Oak, 48073 Lewis Center, OH, 43035 Kalamazoo, 49009 Troy, 48084

800 482-4881 248 435-4472 740 549-2426 269 488-3277 248 816-6881

http://www.giftoflifemichigan.org http://www.giridiagnostics.com http://www.gsk.com http://www.globalclinicalconnections.com http://www.gopharmaceutical.com

Global Remediation Technologies Inc. 1102 Cass St. Global Strategic Connections, LLC 2125 Butterfield Dr. GlyTag LLC 32375 Lahser Rd. GotebörgBio - BRG 3260 Homestead Court Graminex, LLC 95 Midland Rd.

Traverse City, 49684 Troy, 48084 Beverly Hills, 48025 Saline, 48176 Saginaw, 48638

800 899-3703 248 816-6881 313 577-9827 734 429-4961 877 472-6469

http://www.grtusa.com http://www.gsc-llc.com http://www.glytag.com http://www.goteborgbio.se http://www.graminex.com

Grand River Aseptic Manufacturing P.O. Box 3696 Grand Valley State University 301 Michigan St. NE Grand Valley State University - Center for Entrepreneurship Center for Entrepreneurship & Innovation Great Lakes Drug Development, Inc. 123 Brighton Lake Rd. Great Lakes Entrepreneur’s Quest 3520 Green Ct., Ste. 450

Grand Rapids, 49501 Grand Rapids, 49503 Grand Rapids, 49504

616 331-6980 616 331-8643 616 331-7257

http://www.GrandRiverAPP.com http://www.gvsu.edu http://www.gvsu.edu/cei

Brighton, 48116 Ann Arbor, 48105

810 224-7500 734 647-8951

http://www.gldrugdev.com http://www.gleq.org

Greater Mid-Michigan Bio-Manufacturing Alliance (GMBMA) H2 EnviroFuel HAC of America, Inc. Hamztec LLC Hanger Prosthetics & Orthodics

1614 East Kalamazoo

Lansing, 48912

517 999-3382

N/A

P.O. Box 36129 1111 W.Centre Ave. 1039 Olivia Ave. 2314 Gull Rd.

Grosse Pointe Shores, 48236 Portage, 49024 Ann Arbor, 48104 Kalamazoo, 49001

910 232-7601 800 445-9968 734 476-8502 269 345-1117

N/A http://www.hacofamerica.com N/A http://www.hanger.com/Pages/default.aspx

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D I R E C TO RY & R E S O U R C E G U I D E

Hart Enterprises 400 Applejack Ct. Sparta, 49345 616 887-0400 http://www.hartneedles.com Harvard Drug Company 31778 Enterprise Dr. Livonia, 48150 800 875-0123 http://www.harvarddrugs.com Haviland Enterprises 421 Ann NW Grand Rapids, 49504 800 456-1134 http://www.havilandusa.com Haworth, Inc. One Haworth Ctr. Holland, 49423 616 393-3000 http://www.haworth.com Healthcare Management 31580 N. River Rd. Harrison Township, 48045 586 203-8257 http://www.nutrientpharmacology.com Associates, Inc.

HealthCure, LLC Healthmark Industries Company Inc HealthMedia, Inc. Healthtreat, Inc Hearing Health Science

390 Park St., Ste. 110 33671 Doreka Dr. 130 S. First St. 30777 Northwestern Hwy., Ste. 300 1327 Jones Dr., Ste. 201

Birmingham, 48009 Fraser, 48026 Ann Arbor, 48104 Farmington Hills, 48334 Ann Arbor, 48105

248 282-9300 800 521-6224 734 623-0000 248 855-0033 734 476-9490

http://www.healthcure.biz http://www.hmark.com http://www.healthmedia.com http://www.healthtreat.com http://www.hearinghealthscience.com

Helix Biological Laboratory Helvetia Development Company LLC Henry Ford Community College Henry Ford Health Sciences Center Henry Ford Health System

28044 James Dr. 225 Parsons St. 5101 Evergreen Rd. 2799 W. Grand Blvd., ER-7099 2799 W. Grand Blvd.

Warren, 48092 Kalamazoo, 49007 Dearborn, 48128 Detroit, 48202 Detroit, 48202

586 806-4243 877 626-5704 800 585-HFCC 800 653-6568 313 916-2024

http://www.helixbiolab.com http://www.conformamed.com http://www.hfcc.edu http://www.henryfordhealth.org http://www.Henryford.com

Henry Ford Hospital Herman Miller Inc HistoSonics, LLC HoMedics Honeywell Burdick & Jackson

2799 W. Grand Blvd.

855 E. Main Ave. 3626 W. Liberty Rd. 3000 N. Pontiac Tr. 1953 S. Harvey St.

Detroit, 48202 Zeeland, 49464 Ann Arbor, 48103 Commerce Twp., 48390 Muskegon, 49442

800 436-7936 616 654-3000 734 926-4630 248 863-3000 231 726-3171

http://www.henryfordhealth.org http://www.hermanmiller.com http://www.histosonics.com http://www.homedics.com http://www.bandj.com

Honigman Miller Schwartz and Cohn LLP Hoover Precision Products, LLC Horseshoe Herbals Housey Pharmaceutical Research Laboratories, LLC Hygieia, Inc.

350 E. Michigan Ave., Ste. 300

Kalamazoo, 49007

269 337-7700

http://www.honigman.com

1390 Industrial Park Dr. 1219 Anderson Rd. 16800 W. 12 Mile Rd., Ste. 201

Sault Ste. Marie, 49783 Niles, 49120 Southfield, 48076

906 632-7310 269 684-6888 248 663-7000

http://www.hooverprecisionplastics.com http://www.horseshoeherbals.com http://www.housey.com

330 E. Liberty St., Lower Lvl.

Ann Arbor, 48104

734 527-9160

http://www.hygieiamedical.com

Hylant Group i3 STATPROBE, Inc. ImBio, LLC In the Groove, LLC Incept BioSystems

24 Frank Lloyd Wright Dr., Ste. J4100 300 W. Morgan Rd. P.O. Box 131256 7600 Madeline St. 401 W. Morgan Rd.

Ann Arbor, 48105 Ann Arbor, 48108 Ann Arbor, 48113 Saginaw, 48609 Ann Arbor, 48108

734 741-0044 866 427-6848 734 223-2142 517 781-6030 734 302-3598

http://www.hylant.com http://www.i3statprobe.com http://imbio.com http://www.inthegroovebrace.com http://www.inceptbio.com

InformMed Inland Waters Pollution Control InnerSpace Corporation InnoMotus LLC Innova Therapeutics

1710 Hermitage Rd. 2021 S. Schaefer Hwy. P.O. Box 2186 3710 Frains Lake 800 Technology Dr.

Ann Arbor, 48104 Detroit, 48217 Grand Rapids, 49501 Ann Arbor, 48105 Ann Arbor, 48108

734 332-0612 800 992-9118 616 224-2828 N/A 734 222-9900

http://www.informmed.com http://www.soave.com/core/diversified_inland.php http://www.stanleyinnerspace.com N/A N/A

Innovational Therapeutics Innovative Analytics Innovative BioTherapies, Inc. Innovative Research Inc. Innovative Surgical Solutions, LLC

1404 Cambridge Rd. 161 E. Michigan Ave., Haymarket 5th 401 W. Morgan Rd. 46430 Peary Ct. 21520 Bridge St.

Ann Arbor, 48104 Kalamazoo, 49007 Ann Arbor, 48108 Novi, 48377 Southfield, 48033

734 914-0550 269 488-3200 734 213-8350 248 896-0145 248 416-0740

N/A http://www.ianalytics.biz http://www.innbio.com http://www.innov-research.com http://www.innovativesurgery.com

INRAD, Inc. 4375 Donker Ct. SE Kentwood, 49512 616 301-7800 http://www.inrad-inc.com Insight Institute of Neurosurgery 4800 S. Saginaw St. Flint, 48507 810 732-8336 http://www.iinn.com and Neuroscience Institute for Health Studies Michigan State Univ., D 132 W. Fee Hall East Lansing, 48824 517 349-1137 http://www.instituteforhealthstudies.com Institute for Preventive Sports P.O. Box 7032 Ann Arbor, 48107 734 434-3390 http://www.ipsm.org Medicine

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Integrated Compliance Solutions, LLC 4628 Landing Way Kalamazoo, 49048 269 383-5994 N/A Integrated Nonclinical Development 3005 Miller Ave. Ann Arbor, 48103 734 929-5392 http://www.INDS-Inc.com Solutions, Inc. (INDS) Integrated Sensing Systems (ISSYS) 391 Airport Industrial Dr. Ypsilanti, 48198 734 547-9896 http://www.mems-issys.com Intermediary Biochemicals, LLC 2529 Dustin Rd. Okemos, 48864 517 336-4612 N/A International Diagnostics 2620 S. Cleveland Ave., Ste. 100 St. Joseph, 49085 269 428-8400 http://www.ids-kits.com Systems Corp.

International Discovery Sourcing 300 N. Main St., Ste. 202 Chelsea, 48118 734 433-9670 http://www.idscbiotechnetwork.com Consultants LLC International Food Protection 49 W. Michigan Ave., Ste. 300 Battle Creek, 49017 269 441-2995 http://www.ifpti.org Training Institute International Partnership for Critical 828 W. Grand River Ave. Brighton, 48116 810 229-4158 http://www.cmod.org Markers of Disease (CMOD) Intertek 4700 Broadmoor, Ste. 200 Kentwood, 49512 616 656-0601 http://www.intertek.com Intervention Insights 710 Kenmoor, Ste. 120 Grand Rapids, 49546 616 949-7500 http://www.interventioninsights.com

INVIA Medical Imaging Solutions IPGDx LLC J. Rettenmaier, USA Jasper Clinical Research & Development, Inc. JHP Pharmaceuticals

3025 Boardwalk St., Ste. 200 P.O. Box 253 16369 US Hwy. 131 526 Jasper St.

Ann Arbor, 48108 Harrisville, 48740 Schoolcraft, 49087 Kalamazoo, 49007

734 205-1231 989 724-5631 877 895-4099 269 276-8869

http://www.inviasolutions.com http://www.ipgdx.com http://www.jrsusa.com http://www.jasperclinic.com

870 Parkdale Rd.

Rochester, 48307

248 656-5223

http://www.jhppharma.com

Jiva Pharma, Inc. Johnson & Johnson Juvenile Diabetes Research Foundation JV Biolabs Kalamazoo College

2929 Plymouth Rd., Ste. 207 One Johnson & Johnson Plaza 24359 Northwestern Hwy., #225

Ann Arbor, 48105 734 262-0673 New Brunswick, NJ, 08933 732 524-0400 Southfield, 48075 248 355-1133

http://www.jivapharma.com http://www.jnj.com http://www.jdrfdetroit.org

2245 S. State St. 1200 Academy St.

Ann Arbor, 48104 Kalamazoo, 49006

734 395-7436 269 337-7000

http://www.jvbiolabs.com http://www.kzoo.edu

Kalamazoo College - Center for Complex System Studies Kalamazoo Valley Community College Kalexsyn, Inc. Kalsec Inc. Kapnick Insurance Group

1200 Academy St.

Kalamazoo, 49006

269 337-5720

http://www.kzoo.edu/physics/ccss

7107 Elm Valley Dr. 4502 Campus Dr. 3713 W. Main St. 950 Victors Way, Ste. 10

Kalamazoo, 49009 Kalamazoo, 49008 Kalamazoo, 49006 Ann Arbor, 48108

269 353-1582 269 488-8488 269 349-9711 888 263-4656

http://www.kvcc.edu http://www.kalexsyn.com http://www.kalsec.com http://www.kapnick.com

KAR Bioanalytical, Inc. Kellogg Company Kelly Services Kendle International Kestrel Consultants, Inc.

4425 Manchester Rd. One Kellogg Sq. 999 W. Big Beaver Rd. 315 E. Eisenhower Pkwy., Ste. 214 410 Rose Dr.

Kalamazoo, 49001 Battle Creek, 49016 Troy, 48084 Ann Arbor, 48108 Ann Arbor, 48103

269 381-9666 800 962-1413 248 244-4437 734 274-8500 734 576-3031

http://www.karbio.com http://www.kelloggcompany.com http://www.kellyservices.com http://www.kendle.com http://www.KestrelConsultants.com

Kettering University Kettering University - Cooperative Education and Career Services Dept.

Keystone Solutions Group KnowledgeWatch Koch’s Orthotics and Prosthetics

1700 W. Third Ave. 1700 University Ave.

Flint, 48504 Flint, 48504

810 762-9811 810 762-9500

http://www.kettering.edu http://kettering.edu

5121 E. ML Ave., Ste. B-10 1327 Jones Dr. 5315 Elliot Dr., Ste. 104

Kalamazoo, 49048 Ann Arbor, 48105 Ypsilanti, 48197

269 343-4108 248 427-0726 734 434-0442

http://www.keystone-pd.com http://www.knowledgewatch.com N/A

3005 Whisperwood Dr., #288 28465 Beverly Rd. 3327 Ranger Rd. 7707 Lyndon 7560 Lewis Ave.

Ann Arbor, 48105 Romulus, 48174 Lansing, 48906 Detroit, 48238 Temperance, 48182

734 272-5885 734 641-3763 877 938-6738 313 862-1737 734 847-3847

N/A http://www.koppertonline.com http://www.ktmindustries.com N/A N/A

Komgen Koppert Biological Systems, Inc. KTM Industries Labtech Industries Lake Erie Wholesale Medical Supply

MichBio Member Ag-Bio/Industrial Testing

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Lake Superior State University Lake Superior State University - Product Development Center LaMed, Inc Lansing Community College Lansing Community College - Molecular Biotechnology AAS Degree Program

650 Easterday Ave. 650 Easterday Ave.

Sault Ste. Marie, 49783 Sault Ste. Marie, 49783

906 632-6841 906 635-2738

http://www.lssu.edu/eng/pdc http://www.lssu.edu/eng/pdc

54283 Meadowood Ct., Ste. 610 P.O. Box 40010 Box 40010 - MC:5400

Shelby Township, 48316 Lansing, 48901 Lansing, 48901

248 650-0476 517 483-1957 517 483-1092

http://www.lamedinc.com http://www.lcc.edu http://www.mi-asm.org/MBP

Laser Mechanisms, Inc. / Oxid Corporation Law Offices of Gary Kendra, PC Lawrence Technological University LDI Incorporated Lead Biopharma Consulting, LLC

25275 Regency Dr.

Novi, 48375

248 474-9817

http://www.Oxid.com

143 Cady Centre, #319 2100 W. Ten Mile Rd. 4311 Patterson SE 7726 Brass Creek Ct.

Northville, 48167 Southfield, 48075 Grand Rapids, 49512 Dexter, 48130

248 596-1879 248 204-3160 N/A 734 418-2296

http://www.kendralaw.com http://www.ltu.edu http://www.ldiinc.com http://www.leadbiopharma.com

Leap Incorporated LexaMed, Ltd. Life Magnetics Linde Gas Lodox PTY LTD

500 E. Michigan Ave., Ste. 202 705 Front St. 1600 Huron Pkwy., Bldg. 520, 2nd Fl. 2100 Western Ct., Ste. 100 23360 Clarkshire

Lansing, 48912 Toledo, OH, 43650 Ann Arbor, 48109 Lisle, IL, 60532 South Lyon, 48178

517 702-3387 419 693-5307 734 277-2378 734 424-1327 248 446-8480

http://www.leapincorporated.com http://www.lexamed.net http://www.lifemagnetics.com http://www.lindeus.com http://www.lodox.com

LVAD Technology, Inc. Lycera Corporation Lyman & Sheets Insurance Agency Lynn Medical Instruments Mager Scientific Inc.

300 River Pl., Ste. 6850 46701 N. Commerce Center Dr., Ste. C 2213 E. Grand River Ave. P.O. Box 930459 1100 Baker Rd.

Detroit, 48207 Plymouth, 48170 Lansing, 48901 Wixom, 48393 Dexter, 48130

313 446-2800 734 233-3060 517 482-2211 248 560-4500 734 426-3885

http://www.lvadtech.com http://www.lycera.com http://www.lymansheets.com http://www.lynnmed.com http://www.magersci.com

Major Pharmaceuticals MarketLab Inc Marketwire Maximax Pharmaceutical Research Mayaterials, Inc.

31778 Enterprise Dr. 6850 Southbelt Dr. 200 W. Adams St., Ste. 2725 35560 Grand River, Ste. 292 661 Airport Blvd., Ste. 1

Livonia, 48150 Caledonia, 49316 Chicago, IL, 60606 Farmington Hills, 48335 Ann Arbor, 48108

734 427-2576 616 656-2484 312 261-4212 248 434-0180 734 994-7035

http://www.majorpharmaceuticals.com http://www.marketlabinc.com http://www.marketwire.com http://www.maximax.com http://www.mayaterials.com

MBI International McClinchey Histology Lab, Inc. McKesson Pharmacy Systems Mead Johnson Nutrition MedArray, Inc.

3815 Technology Blvd.

100 Rice St. 30881 Schoolcraft Rd. 725 E. Main St. 3915 Research Park Dr., Ste. A-4

Lansing, 48910 Stockbridge, 49285 Livonia, 48150 Zeeland, 49464 Ann Arbor, 48108

517 337-3181 517 851-9149 734 779-8800 812 429-5000 734 769-1066

http://www.mbi.org http://www.mhistolab.com http://www.mckesson.com http://www.meadjohnson.com http://www.permselect.com

Medbio, Inc. MedElephant, Inc. MedElute, Inc. Medical Accessories & Research Corporation Medical Imaging Resources, Inc.

630 S. Division Ave. 21700 Northwestern Hwy., Ste. 110 259 E. Michigan Ave., Ste. 407 219 N. Church St.

Grand Rapids, 49503 Southfield, 48075 Kalamazoo, 49007 Zeeland, 49464

616 245-0214 248 440-6640 269 352-3760 888 527-6272

http://www.medbioinc.com http://www.medelephant.com N/A http://www.medacc.com

120 Enterprise Dr.

Ann Arbor, 48103

888 323-1316

http://www.mobilemedicalimaging.com

Medical Main Street - Oakland County Planning & Economic Development MedImage, Inc. Medi-Nuclear Corp.

MediQuest Life Sciences, LLC Meditrina Pharmaceuticals, Inc.

1200 Pontiac Lake Rd., Bldg. 41W

Waterford, 48328

248 858-9099

http://www.medicalmainstreet.org

6276 Jackson Rd., Ste. G 30029 Research Dr. 42030 Koppernick Rd., Ste. 309 300 N. Fifth Ave., Ste. 150

Ann Arbor, 48103 New Hudson, 48165 Canton, 48187 Ann Arbor, 48104

734 665-5400 800 423-4226 734 455-7110 734 926-0966

http://www.medimage.com http://www.medinuc.com/index.html http://mediquestlifesciences.com http://www.meditrina.com

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Medtronic MemsTech Merck & Co. Inc. Merit Laboratories, Inc. Merit Network

620 Watson St. SW 42503 Steepleview One Merck Dr. 2680 E. Lansing Dr. 1000 Oakbrook Dr., Ste. 200

Grand Rapids, 49504 616 242-5200 Northville, 48167 734 560-5506 Whitehouse Station, NJ, 08889 908 423-1000 East Lansing, 48823 517 332-0167 Ann Arbor, 48104 734 615-6112

http://www.medtronic.com http://www.memstech.com http://merck.com http://www.meritlabs.com http://www.merit.edu

Metabolic Solutions Development 161 E. Michigan Ave., 4th Fl. Kalamazoo, 49007 269 343-6732 http://www.msdrx.com Company MetagenX, LLC 4316 Aztec Way Okemos, 48864 517 203-0194 N/A MI4Spine, LLC 1070 Timberlake Dr. Bloomfield Hills, 48302 248 535-6953 http://mi4spine.e-shopmall.com Michigan Accelerator Fund I, LLC c/o The Charter Group, Grand Rapids, 49503 616 235-3555 N/A

99 Monroe Ave., NW, Ste. 506 Michigan Agri-Business Association 1501 North Shore Dr., Ste. A East Lansing, 48823 517 332-8663 http://www.miagbiz.org Michigan Animal Model Consortium - Van Andel Research Institute, Grand Rapids, 49503 Center for Technology Excellence 333 Bostwick Ave. Michigan Antibody Technology 333 Bostwick Ave. Grand Rapids, 49503 Center - Center of Technology Excellence Michigan Association of Health Plans 327 Seymour Ave. Lansing, 48933 Michigan Biological Imaging Center - Western Michigan University, Dept. of Kalamazoo, 49008 Center for Technology Excellence Biological Sciences, 3425 Woodhall Michigan Biomass Energy Program 611 W. Ottawa Lansing, 48909

616 234-5684

http://www.ctaalliance.org

616 234-5342

N/A

517 371-3181 http://www.mahp.org 269 387-5640 http://www.wmich.edu/bios/facilities/imaging-center/index.html 517 241-6223 http://www.michigan.gov/biomass

Michigan Center for Biological 3600 Green Ct., Ste. 700 Ann Arbor, 48105 734 615-5914 http://www.ctaalliance.org/MCBI Information - Center for Technology Excellence Michigan Center for Genomic WSU-5197 Biological Science Building, Detroit, 48202 313 577-9605 http://www.ctaalliance.org Technologies 5047 Gullen Mall Michigan Center for Oral Health 1011 North University, Rm. 3228 Ann Arbor, 48109 734 647-4622 http://www.dent.umich.edu/research/clinicalresearch Michigan Center for Structural MSU - Dept of Biochemistry, East Lansing, 48824 517 355-0199 http://mcsb.bch.msu.edu Biology - Center for Technology 310A Biochemistry Excellence http://mctp.path.med.umich.edu/mctp/main/index.jsp Michigan Center for Translational CCGC 5430, 1500 E. Medical Center Dr. Ann Arbor, 48109 734 615-4062 Pathology

Michigan Chemistry Council 326 W. Ottawa, Capitol Corners Lansing, 48933 517 372-8898 http://michiganchemistry.com Michigan Citizens for Stem Cell 27177 Lahser Rd., Ste. 102 Southfield, 48034 248 948-5555 http://www.StemCellResearchforMichigan.com Research and Cures (MCSCRC) Michigan Corn Growers Association/ 12800 Escanaba Dr., Ste. B Dewitt, 48820 517 323-6600 http://www.micorn.org Corn Marketing Program of MI Michigan Critical Care 3550 W. Liberty, Ste. 3 Ann Arbor, 48103 734 995-9089 http://www.mc3corp.com Consultants (MC3) Michigan Dental Association 325 W. Lake Lansing Rd., Ste. C East Lansing, 48823 517 332-8663 http://www.smilemichigan.com

Michigan Diagnostics LLC Michigan Ear Institute

Michigan Economic Development Corporation Michigan Health & Hospital Assoc.

Michigan Health Council

2611 Parmenter Blvd.

30055 Northwestern Hwy., Ste. 101 300 N. Washington Sq.

Royal Oak, 48073 Farmington Hills, 48334 Lansing, 48913

248 435-4472 248 865-4030 517 373-9808

http://www.michdiag.com http://www.stjohndoctors.org http://www.michiganadvantage.org

6215 W. St. Joseph Hwy. 2410 Woodlake Dr.

Lansing, 48917 Okemos, 48864

517 323-3443 517 347-3332

http://www.mha.org http://www.mhc.org

Michigan High Throughput MTEC at Kalamazoo Valley Community Kalamazoo, 49009 269 353-1582 http://mhtsc.kvcc.edu Screening Center - Center of College, 7107 Elm Valley Drive Technology Excellence Michigan Instruments 4717 Talon Ct. SE Grand Rapids, 49512 616 554-9696 http://www.michiganinstruments.com Michigan Life Science and 46701 Commerce Center Dr. Plymouth, 48170 734 233-3050 http://www.mlsic.com Innovation Center (MLSIC) Michigan Manufacturing 47911 Halyard Dr. Plymouth, 48170 888 414-6682 http://www.mmtc.org Technology Center Michigan Medical Device Acclerator 241 E. Michigan Ave. Kalamazoo, 49007 N/A http://www.mmdaccelerator.com

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Michigan Medical Device Association 301 Catrell Dr. Michigan Molecular Institute 1910 W. Saint Andrews Rd. Michigan Nanotechnology Institute 1150 W. Medical Center Dr., for Medicine & Biological Science SPC 5648, 9220C MSRB III Michigan Nurses Association 2310 Jolly Oak Rd. Michigan Orthodontic Appliances 1013 E. 3rd St.

Howell, 48844 Midland, 48640 Ann Arbor, 48109

800 930-5698 989 832-5555 734 647-2777

http://www.mmda.org http://www.mmi.org http://www.nano.med.umich.edu

Okemos, 48864 Royal Oak, 48067

517 349-5818 248 544-0860

http://www.minurses.org N/A

Michigan Orthopedic Services Michigan Osteopathic Association Michigan Primary Care Association Michigan Proteome Consortium - Center for Technology Excellence Michigan Public Health Institute

13450 Farmington Rd. 2445 Woodlake Cir. 7215 Westshire Dr. 300 North Ingalls Bldg., 11th Fl., Rm. 1198

Livonia, 48150 Okemos, 48864 Lansing, 48917 Ann Arbor, 48109

734 513-8205 517 347-1555 517 381-8000 734 763-3130

http://www.michortho.com http://www.mi-osteopathic.org/index.php http://www.mpca.net http://www.proteomeconsortium.org

2440 Woodlake Cir., Ste. 190

Okemos, 48864

517 324-9397

http://www.mphi.org

Michigan Research Institute 401 W. Morgan Rd. Ann Arbor, 48108

Michigan Science Teachers Assoc. 3300 Washtenaw Ave., Ste. 220 Ann Arbor, 48104 Michigan Small Business & Grand Valley State Univ./Seidman Grand Rapids, 49504 Technology Development Center College of Business, 510 W. Fulton St. Michigan Soybean Promotion 140 W. Tuscola St. Frankenmuth, 48734 Committee Michigan State Medical Society 120 W. Saginaw Rd. East Lansing, 48826

734 302-3200 http://www.annarborusa.org/expand-relocate/regional-data/rd-labs-testing 734 973-0433 http://www.msta-mich.org 616 331-7480 http://www.misbtdc.org 989 652-3294

http://www.michigansoybean.org

517 337-1651

http://www.msms.org

Michigan State University 250 Hannah Administration Bldg.

East Lansing, 48824 517 355-8332 http://www.msu.edu Michigan State University - 3536 Engineering Bldg.

East Lansing, 48824 517 353-5013 http://www.egr.msu.edu/DER/labs/bdrl.html BioMechanical Design Research Lab Michigan State University - 322 North Kedzie Hall East Lansing, 48824 517 353-7800 http://bld.msu.edu Biomedical Laboratory Diagnostics Program Michigan State University - 2172 Biomedical Physical Lansing, 48824 517 355-2150 N/A Center for Fundamental Sciences Bldg.

Materials Research Michigan State University - 102 Agriculture Hall East Lansing, 48824 517 355-0232 http://www.maes.msu.edu College of Agriculture & Natural Resources

Michigan State University - A110 East Fee Hall College of Human Medicine Michigan State University - 3410 Engineering Bldg.

College of Engineering Michigan State University - A221 Life Sciences College of Nursing Michigan State University - A-310 East Fee Hall College of Osteopathic Medicine Michigan State University - G-100 Veterinary Medical Ctr. College of Veterinary Medicine

Michigan State University - B405 Life Sciences East Lansing, 48824 517 353-9619 http://phmtox.msu.edu/index.html Dept. of Pharmacology & Toxicology Michigan State University - 2201 Biomedical Physical Sciences Bldg. East Lansing, 48824 517 355-6475 http://www.psl.msu.edu Dept. of Physiology Michigan State University - 1000 Oakland Dr. Kalamazoo, 49008 616 337-6010 http://www.kcms.msu.edu Kalamazoo Center for Medical Studies Michigan State University - 301 Administration Bldg.

East Lansing, 48824 517 355-5040 http://www.cga.msu.edu MSU Technologies Michigan State University - Office of 301 Administration Bldg.

East Lansing, 48824 517 355-5040 http://www.cga.msu.edu Contract and Grant Administration

MichBio Member Ag-Bio/Industrial Testing

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East Lansing, 48824

517 353-1730

http://humanmedicine.msu.edu

East Lansing, 48824

517 355-5113

http://www.egr.msu.edu

East Lansing, 48824

517 355-5765

http://nursing.msu.edu

East Lansing, 48824

517 355-1855

http://www.msu.edu

East Lansing, 48824

517 355-6509

http://cvm.msu.edu

Annual Corporate Sponsor Medical Device Manufacturing Suppliers

Preferred Provider Research & Development Government/Non-Profit

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Michigan State University - Office of 120 W. Saginaw Rd. East Lansing, 48826 517 337-1651 Research & Graduate Studies Michigan State University - 80 Agriculture Hall East Lansing, 48824 517 432-1676 Product Center for Agriculture and Natural Resources Michigan Surgical Equipment LLC 48797 West Rd. Wixom, 48393 248 349-5859 Michigan Technological University 1400 Townsend Dr., Harold Meese Bldg. Houghton, 49931 888 688-1885 Michigan Technological University - 1400 Townsend Dr., Advanced Tech.

Houghton, 49931 906 487-2228 Office of Technology and Development Complex Economic Development

Michigan Technology and Research 2245 S. State St., Ste. 1100 Ann Arbor, 48104 734 222-0009 http://www.MTRInstitute.com Institute, LLC Michigan Universities University of Michigan, Wolverine Tower Ann Arbor, 48109 734 647-5730 http://www.muci.org Commercialization Initiative (MUCI) Rm. 1006, 3003 S. State St. Michigan Venture Capital Association 425 N. Main St. Ann Arbor, 48104 734 223-3750 http://www.michiganvca.org Micro Machine Company 2429 N. Burdick St. Kalamazoo, 49007 269 388-2440 http://www.micromachineco.com Microcide, Inc. 2727 Second Ave. #334 Detroit, 48201 888 342-6279 http://www.microcide.com

MicroDose Life Sciences, LLC Micromyx, LLC Midbrook, Inc. MidMichigan Innovation Center Midwest Cleanroom Associates, Inc.

38955 Hills Tech Dr. 4717 Campus Dr. 2080 Brooklyn Rd. 4520 E. Ashman Rd., Ste. M 2055 Oak Industrial Dr., Ste. A

Farmington Hills, 48331 Kalamazoo, 49008 Jackson, 49203 Midland, 48642 Grand Rapids, 49505

http://www.vprgs.msu.edu http://www.productcenter.msu.edu http://www.michigansurgical.com http://www.admin.mtu.edu/iptc http://www.mtu.edu

248 489-1190 269 372-3758 517 787-3481 989 839-2333 616 458-8533

N/A http://www.micromyx.com http://www.midbrook.com http://www.mmic.us http://www.mcacleanrooms.com

Milad Pharmaceutical Consulting

Miller Technical Services Miller, Canfield, Paddock and Stone, P.L.C. MIR Preclinical Services (Molecular Imaging Research) MIT Enterprise Forum

Michigan Life Science & Innovation Ctr., Plymouth, 48170 46701 Commerce Center Dr., Ste. D 7444 Haggerty Rd. Canton, 48187 840 W. Long Lake Rd., Ste. 200 Troy, 48098

734 664-0394

http://www.miladpharmaconsulting.com

734 738-1961 313 963-6420

http://www.nextmobilitynow.com http://www.millercanfield.com

800 Technology Dr.

Ann Arbor, 48108

734 821-1063

http://www.molecularimaging.com

3765 Sancroft Ave.

West Bloomfield, 48324

N/A

http://www.mitgreatlakes.org

MitoStem MMS Holdings, Inc. Molecular Innovations Inc. Monitor Liability Managers Inc. Monteris Medical, Inc.

440 Burroughs 6880 Commerce Blvd.

46430 Peary Ct. 2850 W. Golf Rd., Ste. 800 350 E. Michigan Ave., Ste. 215

Detroit, 48202 Canton, 48187 Novi, 48377 Rolling Meadows, IL, 60008 Kalamazoo, 49007

313 879-5250 734 245-0310 888 557-5055 847 806-6590 269 372-0455

http://www.mitostem.com http://www.mmsholdings.com http://www.mol-innov.com http://www.monitorliability.com http://www.monteris.com/index.htm

MPI Research MS Bioworks Mt. Clemens Orthopaedic Appliances, Inc MuciMed, Inc M-Vision Inc.

54943 N. Main St. 3950 Varsity Dr. 24432 Crocker Blvd.

Mattawan, 49071 Ann Arbor, 48108 Clinton Township, 48036

269 668-3336 734 929-5083 586 463-3600

http://www.mpiresearch.com http://www.msbioworks.com N/A

259 E. Michigan Ave., Ste. 409 12420 Stanley Dr.

Kalamazoo, 49007 Belleville, 48111

906 842-3212 734 697-3933

N/A http://www.m-visioninc.com

Mycol Balm Laboratories, Inc. MYcroarray (Biodiscovery, LLC) NanoBio Corporation Nanoderm Therapeutics, Inc. NanoSystems Inc.

9595 Raucholz Rd. 5692 Plymouth Rd. 2311 Green Rd., Ste. A 3081 N. Foxridge Ct. 3588 Plymouth Rd., Ste. 326

St. Charles, 48655 Ann Arbor, 48105 Ann Arbor, 48105 Ann Arbor, 48105 Ann Arbor, 48105

989 585-4357 734 998-0751 734 302-4000 734 665-4105 734 274-0020

http://www.mycolbalm.com http://www.mycroarray.com http://www.nanobio.com N/A N/A

NanoVir LLC 4717 Campus Dr., Ste. 1300 Kalamazoo, 49008 269 372-3261 http://www.nanovirpharm.com National Center for Manufacturing 3025 Boardwalk Ann Arbor, 48108 800 222-6267 http://www.ncms.org Sciences National Kidney Foundation of MI 1169 Oak Valley Dr. Ann Arbor, 48108 734 222-9800 http://www.nkfm.org Natural Therapeutics, LLC 401 W. Morgan Rd. Ann Arbor, 48108 888 491-7770 http://www.fungalnailrelief.com Neocutis, Inc. 512 E. 11 Mile Rd., Ste. 100 Royal Oak, 48067 248 544-3140 http://www.neocutis.com

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Neogen Corporation NephRx Corporation NeuMedicine NeuroNexus Technologies, Inc. Nexeton Biomedical, LLC

620 Lesher Pl. 4717 Campus Dr., Ste. 100 800 W. Grand River Ave. 655 Fairfield Ct., Ste. 100 5624 Sherwood Rd.

Lansing, 48912 Kalamazoo, 49008 Brighton, 48116 Ann Arbor, 48108 Oxford, 48371

800 234-5333 269 372-8703 877 563-8633 734 913-8858 248 941-9837

http://www.neogen.com http://www.nephrx.com http://www.neumedicine.com http://www.neuronexustech.com N/A

Next Generation Therapeutics, Inc. NEXT Mobility NextGen Metabolomics, Inc. NextGen Sciences, Inc. Nitrate Elimination Company, Inc.

46701 Commerce Center Dr., Ste. A-6 7444 Haggerty Rd. 7395 Warren Rd. 4401 Varsity Dr., Ste. E 334 Hecla St.

Plymouth, 48170 Canton, 48187 Ann Arbor, 48105 Ann Arbor, 48108 Lake Linden, 49945

734 527-9139 888 489-6398 734 265-0884 734 973-7914 888 648-7283

http://www.nextgenerationtherapeutics.com http://www.nextmobilitynow.com http://www.nextgenmetabolomics.com http://www.nextgensciences.com http://www.nitrate.com

North Bay Bioscience Northern Biomedical Research, Inc. Northern Michigan University Northwest Orthotics-Prosthetic, Inc. Norwind-Cortez

13606 S. W. Bay Shore Dr. 930 W. Sherman Blvd.

309 Cohodas 39830 Grand River, Ste. B1d 305 N. Hewitt

Traverse City, 49685 Muskegon, 49441 Marquette, 49855 Novi, 48375 Ypsilanti, 48197

231 922-2211 231 759-2333 906 227-1000 248 477-1443 734 434-0575

http://www.nbbs.com N/A http://www.nmu.edu N/A N/A

Novalung, Inc. NSF International NuStep Nutriinfo.com Nymirum

3550 W. Liberty, Ste. 3 789 N. Dixboro Rd. 5111 Venture Dr., Ste. 1 41850 W. 11 Mile Rd., Ste. 106 3510 W. Liberty Rd.

Ann Arbor, 48103 Ann Arbor, 48105 Ann Arbor, 48108 Novi, 48375 Ann Arbor, 48103

N/A 734 769-8010 734 769-8180 866 533-7172 734 369-4268

http://www.novalung.com http://www.nsf.org http://www.nustep.com https://www.nutriinfo.com/index_ssl.html http://www.nymirum.com

Oakland Community College Oakland Community College (Orchard Lake Campus) Biotechnology Program Oakland Genetics LLC Oakland University Oakland University - Center for Biomedical Research

2480 Opdyke Rd. 27055 Orchard Lake Rd., C-101

Bloomfield HIlls, 48304 Farmington Hills, 48334

248 341-2000 248 522-3741

http://www.oaklandcc.edu http://www.oaklandcc.edu/MolecularBiotechnology

2925 Bond 520 Dowd Hall Oakland University, 205 SEB

Rochester Hills, 48309 Rochester, 48309 Rochester, 48309

248 257-0000 248 370-2100 248 370-2085

http://www.oaklandgenetics.com http://www.oakland.edu http://www2.oakland.edu/cbr

Oakland University - Eye Research Institute Oakland University - William Beaumont School of Medicine OcuSciences, Inc. Office Depot OLC-BIO, LLC

2200 N. Squirrel Rd.

Rochester, 48309

248 370-2395

http://www.oakland.edu/eri

216 O’Dowd Hall, 2001 N. Squirrel Rd.

Rochester, 48309

248 370-2767

http://www.oakland.edu/medicine

3201 Asher Rd. 800 Eisenhower Pkwy.

8615 Richardson Rd., Ste. 300

Ann Arbor, 48104 Ann Arbor, 48106 Commerce, 48390

734 646-4156 734 259-9281 248 242-5902

http://www.ocusciences.com http://www.officedepot.com http://www.olc-bio.com

Omega Surgical Instruments, Inc. OncoImmune, Inc. Oncologix Tech Ophthigenics LLC Ophthy-DS, Inc.

G-8395 S. Saginaw St. 333 Parkland Plz., Ste. 1000 206 Crown St. SW 2900 Huron Pkwy., Ste. 4 54943 N. Main St.

Grand Blanc, 48439 Ann Arbor, 48103 Grand Rapids, 49548 Ann Arbor, 48105 Mattawan, 49071

800 656-6342 734 332-4234 616 977-9933 734 972-7505 269 250-2177

http://www.omegasurgical.com http://www.oncoimmune.com N/A http://www.ophthigenics.com http://www.Ophthy-DS.com

Optical Dimensions Optical Supply Orchid Bio-Coat Orthopedic Solutions Orchid Bio-Vac Orthopedic Solutions Orchid Stealth

3285 Martin Rd. #110 1526 Plainfield Ave., NE 21249 Bridge St. 21316 Bridge St. 1489 Cedar St.

Walled Lake, 48390 Grand Rapids, 49505 Southfield, 48034 Southfield, 48033 Holt, 48842

800 878-5367 616 361-6000 248 352-4570 248 350-2150 517 694-2300

http://opticaldimensionslab.com/default.aspx http://www.optical-supply.com http://www.orchid-orthopedics.com/biocoat http://www.orchid-orthopedics.com/biovac http://www.orchid-orthopedics.com

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Orchid Unique Orthopedic Solutions Originus, Inc. Orthopedic Development, Inc. Ostial Solutions OtoMedicine, Inc.

6688 Dixie Hwy. 3985 Research Park Dr., Ste. 200 6565 W. Main St. 1111 Short Rd. 330 E. Liberty St., Lower Level

Bridgeport, 48722 Ann Arbor, 48108 Kalamazoo, 49009 Kalamazoo, 49008 Ann Arbor, 48104

989 746-0780 734 913-8791 269 544-4715 269 383-3797 269 615-0668

http://www.orchid-orthopedics.com/unique http://www.originusinc.com N/A http://www.ostialsolutions.net http://www.otomedicine.com

Oxford Biomedical Research, Inc. Painex Corporation Pall Corporation - Life Sciences Paragon Laboratories, Inc. Pathology Experts, LLC

2165 Avon Industrial Dr. 18295 James Couzens Hwy. 600 S. Wagner Rd. 12649 Richfield Ct. 2887 Oakhaven Ct.

Rochester Hills, 48309 Detroit, 48235 Ann Arbor, 48103 Livonia, 48150 Midland, 48642

248 852-4466 313 863-1200 800 521-3160 734 462-3900 989 631-2790

http://www.oxfordbiomed.com http://www.ringmasternow.com/index.html http://www.pall.com http://www.paragonlaboratories.com http://www.pathexperts.com

PBS Biotech Performance Systematix Inc. Performance Validation LLC Perrigo Company Pfizer Inc.

2843 E. Grand River Ave., Ste. 262 5569 33rd St., SE 5148 Lovers Ln., Ste. 200 515 Eastern Ave. 7000 Portage Rd.

East Lansing, 48823 Grand Rapids, 49512 Portage, 49024 Allegan, 49010 Kalamazoo, 49001

888 PBS-0022 616 949-9090 269 373-9112 269 673-8451 269 833-4000

http://pbsbiotech.com http://www.psix.com http://www.perfval.com http://www.perrigo.com http://www.pfizer.com

PG Pharmaceuticals, Inc. Phadia US Pharmaceutical Research and Manufacturers of America (PhRMA) Pharmacision LLC PharmaMed Resources, LLC

2246 N. Monroe St. 4169 Commercial Ave. 950 F St., NW, Suite 300

Monroe, 48162 Portage, 49002 Washington, DC, 20004

248 632-1666 800 346-4364 202 835-3400

http://www.pg-pharma.com http://www.phadia.us http://www.phrma.org

1947 Mistwood Ct. 3616 East T Ave.

Canton, 48187 Portage, 49002

734 895-3670 269 303-0798

http://www.pharmacision.com http://www.pharmamedresources.com

PharmMor Consulting, LLC PharmOptima, LLC Phillips Plastics Corporation Phrixus Pharmaceuticals, Inc. PhycoTech

P.O. Box 2570 6710 Quality Way 5706 Stonington Ct. 300 N. Fifth Ave., Ste. 150 620 Broad St., Ste. 100

Portage, 49081 Portage, 49002 West Bloomfield, 48322 Ann Arbor, 48104 St. Joseph, 49085

269 327-2215 269 329-4370 248 851-8300 734 358-9015 269 983-3654

N/A http://www.pharmoptima.com http://www.phillipsplastics.com http://www.phrixuspharmaceuticals.com http://www.phycotech.com

Physician’s Technology, LLC PICOCAL Pioneer Surgical Technology Pixel Velocity Inc. Plas-Labs, Inc.

23 E. Front St. 333 Parkland Plz. 375 River Park Cir. 3917 Research Park Dr., Ste. 1B 401 E. North St.

Monroe, 48161 Ann Arbor, 48103 Marquette, 49855 Ann Arbor, 48108 Lansing, 48906

734 241-5060 734 913-2608 906 226-9909 734 213-3715 517 372-7177

http://www.willomd.com http://www.picocal.com http://www.pioneersurgical.com http://www.pixel-velocity.com http://www.plas-labs.com

Pointe Scientific, Inc. POLY Bioinformatics Precision Edge Surgical Products Price, Heneveld, Cooper, DeWitt & Litton Progressive Dynamics Medical

5449 Research Dr. P.O. Box 1327 415 W. 12th Ave. 695 Kenmoor SE

Canton, 48188 Ann Arbor, 48106 Sault Ste. Marie, 49783 Grand Rapids, 49501

800 445-9853 734 678-7342 906 632-4800 616 949-9610

http://www.pointescientific.com http://www.polyergic.com http://www.precisionedge.com http://www.priceheneveld.com

507 Industrial Rd.

Marshall, 49068

269 781-4241

http://www.progressivedynamicsmedical.com

ProNAi Therapeutics, Inc. ProPharma Group ProReg Resources, LLC Pros-Tech Prosthetic Center, Inc.

4717 Campus Dr., Ste. 1100 8175 Creekside Dr. 8889 2nd St. 1717 Stephenson Hwy. 1200 S. Washington Ave.

Kalamazoo, 49008 Portage, 49024 Mattawan, 49071 Troy, 48083 Lansing, 48910

269 815-8098 269 321-5170 269 372-2911 248 680-2800 517 372-7007

http://www.pronai.com http://www.propharmagroup.com http://www.proregresources.com http://www.pros-tech.com N/A

Proteos, Inc. Proud Mary Prosthetics PVS Chemicals, Inc. Qtox, LLC Quality Air Service, Inc.

4717 Campus Dr. 6305 Wall St. 10900 Harper Ave. 1828 Yosemite Dr. 6701 Quality Way

Kalamazoo, 49008 Sterling Heights, 48312 Detroit, 48213 Okemos, 48864 Portage, 49002

269 372-3423 877 627-9272 313 921-1200 517 944-2022 269 327-3055

http://www.proteos.net http://www.proudmaryprosthetics.com http://www.pvschemicals.com N/A http://www.qairservice.com

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Quality Care Products Quantum Laboratories QuatRx Pharmaceuticals Quest Diagnostics Incorporated Quest Research Institute

7560 Lewis Ave. 28221 Beck Rd., Ste. A-11 777 E. Eisenhower Pkwy., Ste. 100 4444 Giddings Rd. 31000 Telegraph, Ste. 230

Temperance, 48182 Wixom, 48393 Ann Arbor, 48108 Auburn Hills, 48326 Bingham Farms, 48025

734 847-3847 248 348-8378 734 913-9900 248 373-9120 248 644-7770

http://www.qcpmeds.com http://www.quantumlaboratories.com http://www.quatrx.com http://www.questdiagnostics.com http://www.questri.com

Rader, Fishman & Grauer PLLC Ranir, LLC Rapid BioSense RealBio Technology, Inc. Regional Medical Lab, Inc.

39533 Woodward Ave., Suite 140 4701 E. Paris Ave. SE 3900 Collins Rd. 4717 Campus Dr., Ste. 1500 175 College St.

Bloomfield Hills, 48304 Grand Rapids, 49512 Lansing, 48910 Kalamazoo, 49008 Battle Creek, 49037

248 594-0600 616 698-8880 800 579-4913 269 544-1088 269 969-6161

http://www.raderfishman.com http://www.ranir.com http://www.rapidbiosense.com http://www.realbiotechnology.com http://www.rml-lab.com

ReNew Systems Renko Enterprises, LLC Research Essential Services RetroSense Therapeutics, LLC RG Medical Diagnostics

P.O. Box 1072 25344 Carollton Dr. 46701 Commerce Center Dr. P.O. Box 625 28351 Beck Rd., Ste. G5

Bay City, 48706 Farmington Hills, 48335 Plymouth, 48170 Northville, 48167 Wixom, 48393

989 892-4552 248 342-6472 734 645-1276 248 924-3298 888 596-9498

http://www.renewsystems.com N/A http://www.ressential.com http://www.retro-sense.com http://www.rgmd.com

Richard-Allan Scientific Rigaku Innovative Technologies RightAnswer.com, Inc. RJL Systems, Inc. Robertson Research Institute

4481 Campus Dr. 1900 Taylor Rd. 4520 E. Ashman Rd., Ste. R 33939 Harper Ave. 4215 Fashion Square Blvd.

Kalamazoo, 49008 Auburn Hills, 48326 Midland, 48642 Clinton Township, 48035 Saginaw, 48603

616 644-2400 248 232-6400 989 835-5000 586 790-0200 989 799-8720

http://www.rallansci.com http://www.rigaku.com http://www.rightanswer.com http://www.rjlsystems.com http://www.robertsoninstitute.org

Roche Labs Rockwell Medical Technologies, Inc. Rose Technologies Roush Life Sciences RTI Health Solutions

38777 Six-Mile Rd. 30142 Wixom Rd. 1440 Front Ave. NW 12447 Levan 3005 Boardwalk St., Ste. 105

Livonia, 48152 Wixom, 48393 Grand Rapids, 49504 Livonia, 48150 Ann Arbor, 48108

734 525-0248 248 960-9009 616 233-3000 734 779-7006 734 213-5372

N/A http://www.rockwellmed.com http://www.rose-technologies.com http://www.roush.com http://www.rtihs.org

RTI Laboratories, Inc. Rubicon Genomics, Inc. RxDispense, Inc. S & J Laboratories Saginaw Valley State University

33080 Industrial Rd. 4355 Varsity Dr., Ste. E 2706 Cumberland 4669 Executive Dr. 7400 Bay Rd.

Livonia, 48150 Ann Arbor, 48108 Berkley, 48072 Portage, 49002 University Center, 48710

734 422-8000 734 677-4845 734 277-0668 269 324-7383 989 964-4080

http://www.rtilab.com http://www.rubicongenomics.com http://www.rxdispense.com http://www.sandjlab.com/index.html http://www.svsu.edu

Sakor Technologies, Inc. SanoBio Therapeutics LLC sanofi-aventis US ScarPrev Pharmaceuticals Science Direct

2855 W. Jolly Rd. 808 E. Kingsley 55 Corporate Dr. 917 Packard St. 3675 Crestwood Pkwy., Ste. 400

Okemos, 48864 Ann Arbor, 48104 Bridgewater, NJ, 08807 Ann Arbor, 48104 Duluth, GA, 30096

517 332-7256 N/A 636 273-5409 734 717-9263 770 935-6077

http://www.sakor.com http://sanobio.com http://en.sanofi-aventis.com N/A http://www.elsevier.com

SciMedLit, LLC SciTech Development ScreenTrack Secretory IgA Inc. Secure Mount

2435 Merrill 440 Burroughs, Ste. 520 1603 Peach St. 803 N. Main St. 415 Condad St.

Ypsilanti, 48197 Detroit, 48236 Ann Arbor, 48105 Ann Arbor, 48104 Jackson, 49202

734 972-5333 313 966-7317 734 665-0701 734 994-0966 517 784-9613

http://www.scimedlit.com http://www.scitechdevelopment.com N/A http://www.secretoryiga.com http://www.securemount.com

132 W. First St. 440 Burroughs St., Ste. 170 1039 Olivia Ave. 301 Michigan St. NE, Ste. 580

Flint, 48502 Detroit, 48202 Ann Arbor, 48104 Grand Rapids, 49503

810 767-7530 313 882-1065 734 476-8502 616 391-4330

N/A http://www.sensound.com N/A http://www.cmmdx.org

440 Burroughs, Ste. 340

Detroit, 48202

313 894-4440

http://www.shraderlabs.com

Selective Technologies, Inc. SenSound, LLC Sentry Medical Technologies Sequenom Center for Molecular Medicine Shrader Analytical and Consulting Laboratories, Inc.

MichBio Member Ag-Bio/Industrial Testing

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Siemens Ultrasound Division Signal Medical Corporation Sikich Investment Banking Single Source Procurement, LLC SkinTreet, LLC

400 W. Morgan Rd. 400 Pyramid 225 W. Washington, Ste. 1610 4717 Campus Dr. 1120 Olivia Ave.

Ann Arbor, 48108 Marysville, 48040 Chicago, IL, 60606 Kalamazoo, 49008 Ann Arbor, 48104

734 995-5010 810 364-7070 312 458-0000 269 372-3997 734 663-5999

http://www.usa.siemens.com http://www.signalmd.com http://www.sikich.com http://www.sspusa.com N/A

Skyline Property Group, Inc. Skytron Slaughter Instrument Co. Soar Technology, Inc. SoloHill Engineering, Inc.

2146 Livernois 5085 Corporate Exchange Blvd.

4356 N. Roosevelt 3600 Green Ct., Ste. 600 4370 Varsity Dr., Ste. B

Troy, 48083 Grand Rapids, 49512 Stevensville, 49127 Ann Arbor, 48105 Ann Arbor, 48108

248 680-9900 800 759-8766 269 428-7471 734 327-8000 734 973-2956

http://www.commercialrealestatemichigan.net http://www.skytron.us http://www.slaughtercoinc.com http://www.soartech.com http://www.solohill.com

Somanetics Corporation Sonetics Ultrasound, Inc. Southwest Michigan First Southwest Michigan Innovation Center Spartan Medical Supply

2600 Troy Center Dr. 3550 W. Liberty, Ste. 3 241 E. Michigan Ave. 4717 Campus Dr., Ste. 100

Troy, 48084 Ann Arbor, 48103 Kalamazoo, 49024 Kalamazoo, 49008

248 244-1400 734 260-4800 269 553-9588 269 353-1823

http://www.somanetics.com N/A http://www.southwestmichiganfirst.com http://www.kazoosmic.com

50762 Kiawah Tr.

Mattawan, 49071

866 894-5118

http://www.spartanmedicalsupply.com

P.O. Box 226 5126 Girard Dr. 2929 Plymouth Rd. 44467 Charnwood Dr. 29580 Northwestern Hwy., Ste. 110

Grand Haven, 49417 Pinckney, 48169 Ann Arbor, 48105 Plymouth, 48170 Southfield, 48034

231 935-6900 810 231-6600 734 262-0673 734 417-4970 248 343-4842

http://www.spipharma.com N/A http://ssvtherapeutics.com http://www.staubli.com http://www.stemcellgrowthinc.com

SPI Pharma Spinal Ventures, LLC SSV Therapeutics, LLC Staubli Corporation Stem Cell Growth Inc.

Sterling Diagnostics 36645 Metro Ct. Sterling Heights, 48312 Stryker Corporation 2825 Airview Blvd.

Kalamazoo, 49002 Stryker Instruments 4100 E. Milham Ave. Kalamazoo, 49001 Stryker Interventional Pain 2825 Airview Blvd.

Kalamazoo, 49002 Stryker Orthopaedics 44736 Helm St. Plymouth, 48170

586 979-2141 http://www.sterlingdiagnostics.com 269 385-2600 http://www.stryker.com 269 323-7700 http://www.stryker.com/instruments 269 385-2600 N/A 734 454-0023 http://www.stryker.com/en-us/corporate/ContactUs/Orthopaedics/index.htm

Stryker Osteosynthesis SubTerra LLC Sunapten Therapeutics, Inc. Superior Growers Supply Surefil LLC

2825 Airview Blvd.

104 Wilcox Rd. 4717 Campus Dr., Ste. 1000 4870 Dawn Ave. 4560 Danvers Dr. SE

Kalamazoo, 49002 White Pine, 49971 Kalamazoo, 49008 East Lansing, 48823 Grand Rapids, 49512

N/A 906 885-5953 N/A 800 227-0027 616 532-1700

http://www.osteosynthesis.stryker.com http://www.subterrallc.com http://www.sunapten.com http://www.superiorgrowers.com http://www.surefil.com

Surface Enhancement Solutions Surge Medical Solutions SurgiTel Swift Biosciences Symmetry Jet

320 Hillboro Dr. 8850 M-89 77 Enterprise Dr. 58 Parkland Plz., Ste. 100 5212 Aurelius Rd.

Bloomfield Hills, 48301 Richland, 49083 Ann Arbor, 48103 Ann Arbor, 48103 Lansing, 48911

248 930-0851 888 307-1144 734 996-9200 734 678-7689 517 882-4311

http://surfaceenhancementsolutions.com http://www.surgemedical.com http://www.surgitel.com http://swiftbiosci.com http://www.symmetrymedical.com

syncreon Systems Specialties Takeda Pharmaceuticals North America, Inc. Tangent Medical Technologies, LLC TCH Pharmaceuticals, Inc.

2851 High Meadow Cir., Ste. 250 390 Enterprise Ct., Ste. 200 One Takeda Pkwy.

Auburn Hills, 48326 Bloomfield Hills, 48302 Deerfield, IL, 60015

248 377 4700 248 332-0099 224 554-6500

http://www.syncreon.com http://www.sysspec.com http://www.tpna.com

2132 Packard St. 300 N. Fifth Ave., Ste. 150

Ann Arbor, 48104 Ann Arbor, 48104

734 330-2668 734 926-0966

http://www.tangentmedical.com N/A

Team Pharmaceutical Inc. Team Support Services Tech Depot Tech Initiatives Inc. Teclab

563 116th Ave. P.O. Box 19536 6 Cambridge Dr. 200 Michigan St., Ste. 408 6450 Valley Industrial Dr.

Martin, 49070 Kalamazoo, 49019 Trumbull, CT, 06611 Hancock, 49930 Kalamazoo, 49009

269 388-5708 269 226-0016 203 615-7437 906 483-2676 269 372-6000

N/A http://teamsupportservices.com http://www.techdepot.com http://www.cprmattress.com http://www.teclab.com

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BioMatters | Spring 2011

D I R E C TO RY & R E S O U R C E G U I D E

Tekna Teresa M. Arnold & Associates Terumo Cardiovascular Systems Terumo Heart, Inc. Teter Orthotics & Prosthetics, Inc.

3400 Tech Cir. 8300 Adler Rd. 6200 Jackson Rd. 6190 Jackson Rd. 1225 W. Front St.

Kalamazoo, 49008 Lambertville, 48144 Ann Arbor, 48103 Ann Arbor, 48103 Traverse City, 49684

269 978-3500 734 854-1187 734 663-4145 800 262-3304 231 947-5701

http://www.teknalink.com http://www.tmaapr.com http://www.terumo-cvs.com http://www.terumoheart.com http://www.teterop.com

The Dow Chemical Company The More Program The MRI Institute for Biomedical Research Imaging The Project Group The Right Place, Inc.

2030 Dow Ctr. 500 Griswold St., Ste. 3400 440 E. Ferry St., Unit 2

Midland, 48674 Detroit, 48226 Detroit, 48202

800 258-2436 313 223-2515 313 758-0065

http://www.dowventurecapital.com http://www.themoreprogram.com http://www.mrimaging.com

7238 Windhaven Ct. 161 Ottawa Ave. NW, Ste. 400

Portage, 49024 Grand Rapids, 49503

269 321-0411 616 771-0325

N/A http://www.rightplace.org

The Standing Company The Tech Group The Timberland Group Therapeutics Systems Research Laboratories, Inc. Therapy Charts LLC

5848 Dixie Hwy. 3116 N. Wilson Ct. NW 1707 W. Big Beaver Rd. 540 Avis Dr., Ste. A

Saginaw, 48601 Walker, 49534 Troy, 48084 Ann Arbor, 48108

800 782-6346 616 643-6001 800 695-2921 734 663-4233

http://www.thestandingcompany.com http://www.techgroup.com http://www.timberlandgroup.com http://www.tsrlinc.com

228 Nickels Arcade

Ann Arbor, 48104

866 288-9758

http://www.therapycharts.com

Thompson Surgical Instruments Thomson Reuters Thorn Smith Laboratories Thumb MRI Center, LLC Thumb Oilseed Producers

10170 E. Cherry Bend Rd. 777 E. Eisenhower Pkwy.

7755 Narrow Gauge Rd. 6320 Van Dyke Rd. 2145 Leppek Rd.

Traverse City, 49684 Ann Arbor, 48108 Beulah, 49617 Cass City, 48726 Ubly, 48475

231 922-0177 734 913-3000 231 882-4672 888 399-9469 989 658-2344

http://www.thompsonsurgical.com http://www.thomsonreuters.com http://www.thornsmithlabs.com http://www.thumbmri.com http://www.thumboilseed.com

Tissue Regeneration Systems 401 W. Morgan Rd. Ann Arbor, 48108 N/A N/A Tolera Therapeutics, Inc. 350 E. Michigan Ave., Ste. 205 Kalamazoo, 49007 269 585-2100 http://www.tolera.com Topspins, Inc. P.O. Box 7205 Ann Arbor, 48107 734 623-6400 http://www.topspins.com Tower Laboratories Montague 8060 Whitbeck Rd. Montague, 49437 231 893-1472 http://www.towerlabs.com Toxicogenomic Informatics P.O. Box 27482 Lansing, 48909 N/A http://www.txisllc.com and Solutions, LLC

TransPharm Preclinical Solutions, LLC Traxx Mobility Systems LLC Trialon Corporation Trialynx, Inc. Trossen HR Group

7190 S. Brooklyn Rd. 33750 Freedom Rd. 5600 New King St., Ste. 345 2400 Frank Lloyd Wright Dr., Ste. H1200 58 Parkland Plaza, Ste. 200

Jackson, 49201 Farmington, 48335 Troy, 48098 Ann Arbor, 48105 Ann Arbor, 48103

517 536-8210 248 426-7700 248 641-1032 734 930-4400 734 330-2588

http://www.transpharmsite.com http://www.traxxms.com http://www.trialon.com http://www.trialynx.com http://www.trossenhr.com

Troy Biologicals, Inc. Troy Polymers Twin Bay Medical, Inc. Twinlab Uckele Health and Nutrition

1238 Rankin St. 330 E. Maple, Ste. L 11590 US-31 S. 3133 Orchard Vista Dr. SE P.O. Box 160

Troy, 48083 Troy, 48083 Williamsburg, 49690 Grand Rapids, 49546 Blissfield, 49228

800 521-0445 248 733-1030 231 264-0101 616 464-5000 800 248-0330

http://www.troybio.com http://www.troypolymers.com http://www.barblock.com http://www.twinlab.com http://www.uckele.com

Ultralight Prosthetics, Inc. Ultrasound Medical Devices, Inc. Unifab Corp.

United BioSource Corporation Unival, Inc.

24781 Five Mile Rd. 3917 Research Park, Ste. B-7 3030 Kersten Ct. 2200 Commonwealth Blvd., Ste. 100 2311 Green Rd., Ste. D

Redford, 48239 Ann Arbor, 48108 Kalamazoo, 49048 Ann Arbor, 48105 Ann Arbor, 48105

313 538-8500 734 369-5056 269 382-2803 734 994-8940 800 332-4463

http://www.ultralightprosthetics.com N/A http://www.unifabcages.com http://www.unitedbiosource.com http://www.unival-med.com

Universal Imaging University of Michigan University of Michigan - A. Alfred Taubman Medical Research Institute University of Michigan - Biomedical Engineering

1159 E. Michigan Ave. 1301 E. Catherine 109 Zina Pitcher Pl., 5017 BSRB

Ypsilanti, 48198 Ann Arbor, 48109 Ann Arbor, 48109

734 528-0657 734 764-1817 734 615-7282

http://www.uimedical.com http://www.umich.edu http://www.med.umich.edu/taubmaninstitute

2200 Bonisteel Blvd.

Ann Arbor, 48109

734 764-9588

http://www.bme.umich.edu

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D I R E C TO RY & R E S O U R C E G U I D E

University of Michigan - Business Engagement Center University of Michigan - Center for Chemical Genomics University of Michigan - Center for Computational Medicine and Biology (CCMB) University of Michigan - Coulter Translational Research Partnership Program University of Michigan - Flint

University of Michigan - 2215 Fuller Rd. Ann Arbor, 48105 734 936-4000 http://www.ann-arbor.med.va.gov Hospitals and Health Center University of Michigan - 1000 Wall St. Ann Arbor, 48105 734 763-8122 http://www.kellogg.umich.edu Kellogg Eye Center University of Michigan - 611 Church St., Rm. 240 Ann Arbor, 48104 734 647-4571 http://www.lss.sph.umich.edu Life Sciences & Society University of Michigan - 210 Washtenaw Ave., 3rd Fl. Ann Arbor, 48109 734 763-1200 http://lis.umich.edu Life Sciences Institute University of Michigan - 1301 Beal Ave. Ann Arbor, 48109 734 763-6719 http://lnf.umich.edu Lurie Nanofabrication Facility

University of Michigan - Medical Innovation Center University of Michigan - Medical School University of Michigan - Medical School Office of Research University of Michigan - Michigan Institute for Clinical Health Research University of Michigan - Nanoscale Neurology Lab

1214 S. University Ave., 2nd Floor

Ann Arbor, 48104

734 647-1000

http://www.bec.umich.edu

210 Washtenaw Ave., LSI

Ann Arbor, 48109

734 763-1200

http://www.lsi.umich.edu

Palmer Commons

Ann Arbor, 48109

734 615-5510

http://www.ccmb.med.umich.edu

University of Michigan Dept. of Biomedical Ann Arbor, 48109 Engineering, 2200 Bonisteel Blvd., 1131 Gerstacker Bldg.

2 E. 1st St. Flint, 48502

734 615-9412

http://www.bme.umich.edu/research/coulter.php

810 767-1863

http://www.umflint.edu

24 Frank Lloyd Wright Dr., Ann Arbor, 48106 734 998-6994 http://www.med.umich.edu/ummic Lobby M, Ste. 2600 W. Medical Center Dr. Ann Arbor, 48109 734 764-8165 http://sitemaker.umich.edu/neubig.lab NCRC 2800 Plymouth Rd., Bldg. 520

Ann Arbor, 48109

734 764-7815

http://www.med.umich.edu/medschool/research

24 Frank Lloyd Wright Dr., Lobby M

Ann Arbor, 48106

734 998-7474

http://www.michr.umich.edu

2215 Fuller Rd.

Ann Arbor, 48105

734 845-3056

https://sites.google.com/site/nanoscaleneurologylab

University of Michigan - 1214 S. University, 2nd Fl. Ann Arbor, 48104 734 763-0614 http://www.techtransfer.umich.edu Office of Technology Transfer University of Michigan - Office of 4080 Fleming Bldg., 503 Thompson Ann Arbor, 48109 734 764-1185 http://www.research.umich.edu the Vice President for Research University of Michigan - 701 Tappan St. Ann Arbor, 48109 734 764-1363 http://www.bus.umich.edu Ross School of Business University of Michigan - Robert H. Lurie Engineering Center, Ann Arbor, 48109 734 647-7000 http://www.engin.umich.edu School of Engineering 1221 Beal St. UPS 2960 Lucerne Dr. SE Grand Rapids, 49546 734 347-2451 http://www.ups.com

Urobiologics LLC VA Medical Center - Ann Arbor Validation & Compliance Institute, LLC Van Andel Institute Van Beek Nutrition Velcura Therapeutics, Inc.

31628 Glendale Ave. 2215 Fuller Rd. 1529 Boxford Rd. 333 Bostwick Ave. NE 3537 W. YZ Ave. 4300 Varsity Dr., Ste. D

Livonia, 48150 Ann Arbor, 48105 Trenton, 48183 Grand Rapids, 49503 Schoolcraft, 49087 Ann Arbor, 48108

313 574-7500 734 930-5100 734 274-4680 616 234-5000 269 679-5441 734 973-1000

http://www.urobiologics.com http://www.hsrd.ann-arbor.med.va.gov http://www.vcillc.com http://www.vai.org http://www.vanbeeknutrition.com http://www.velcura.com

Velesco Pharmaceutical Services Venture Technology Groups Versus Technology, Inc. Vertellus Health and Specialty Products, LLC Vestaron Corporation

46701 N. Commerce Center Dr., Ste. A8 23800 Industrial Park Dr. 2600 Miller Creek Dr. 215 North Centennial St.

Plymouth, 48170 Farmington Hills, 48335 Traverse City, 49684 Zeeland, 49464

734 545-0696 248 473-8450 231 946-5868 800 223-0453

http://www.velescopharma.com http://www.venturegroups.com http://www.versustech.com http://www.vertellus.com

4717 Campus Dr., Ste. 1200

Kalamazoo, 49008

269 372-3108

http://www.vestaron.com

VetGen, LLC ViaDerm, LLC Vigor Therapy Solutions VO2 Ventures LLC

3728 Plaza Dr., Ste. 1 300 River Pl., Ste. 6850 4915 Advance Way 30375 Northwestern Hwy.

Ann Arbor, 48108 Detroit, 48207 Stevensville, 49127 Farmington Hills, 48344

734 669-8440 313 446-2800 800 597-6566 248 358-3956

http://www.vetgen.com N/A http://www.vigorequipment.com http://www.vo2ventures.com

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Vortech Pharmaceuticals VWR International W.F. Valentine & Co. Wacker Chemical Corporation Warde Medical Laboratory

6851 Chase Rd. 4906 Gullane Dr. 7633 Quackenbush 3301 Sutton Rd. 300 W. Textile Rd.

Dearborn, 48126 Ann Arbor, 48103 Reading, 49274 Adrian, 49221 Ann Arbor, 48108

Warner Norcross & Judd LLP 900 Fifth Third Center, 111 Lyon St. NW Grand Rapids, 49503 Wayne State University Anthony Wayne Dr. Detroit, 48202 Wayne State University - 540 E. Canfield, Scott Hall, Rm. 3127 Detroit, 48201 Center for Molecular Medicine & Genetics Wayne State University - 259 Mack Ave. Detroit, 48201 College of Pharmacy & Health Science Wayne State University - 3172 Engineering Bldg., Detroit, 48202 Smart Sensor and Integrated 5050 Anthony Wayne Dr. Microsystems

Wayne State University - Technology Commercialization Wayne State University - TechTown Wayne State University Applied Genomic Technologies - Center for Technology Excellence WelchDry, Inc. Wellness Indicators Inc.

313 584-4088 800 932-5000 517 283-3143 888 922-5374 734 214-0300

http://www.vortechpharm.com http://www.vwr.com http://www.wfvalentine.com http://www.wacker.com http://www.wardelab.com

616 752-2169 https://www.wnj.com 313 577-2424 http://www.wayne.edu 313 577-5323 http://www.genetics.wayne.edu/Education/phd_program_description.htm 313 577-1384

http://www.wayne.edu

313 577-1306

http://www.ssim.eng.wayne.edu/cleanroom

440 Burroughs, Ste. 201

Detroit, 48202

313 577-1345

http://www.techtransfer.wayne.edu

440 Burroughs - Entrepreneurial Suite WSU C.S. Mott Center, 275 E. Hancock

Detroit, 48202 Detroit, 48201

313 879-5250 313 577-6200

http://www.techtownwsu.org/index.htm http://agtc.wayne.edu

4270 Sunnyside Dr. N25 W23050 Paul Rd.

Holland, 49424 Pewaukee, WI, 53072

616 399-2711 414 243-4178

http://www.welchdry.com http://www.wellnessindicators.com

West Michigan Regional Laboratory

West Michigan Science and Technology Initiative

Western Michigan University

Western Slope Laboratory Williams Syndrome Association

1726 Knollcrest Cir. SE 301 Michigan St. NE, Ste. 537, Cook - DeVos Center for Health Sciences, Grand Valley State University Office of the Vice President for Research, 1903 W. Michigan Ave. 1197 Rochester Rd., Ste. K P.O. Box 297

Grand Rapids, 49546 Grand Rapids, 49503

616 526-8440 616 331-5840

http://www.calvin.edu/admin/wmrl http://www.wmsti.org

Kalamazoo, 49008

269 387-1000

http://www.wmich.edu

Troy, 48083 Clawson, 48017

248 307-1168 248 244-2229

http://www.westernslopelabs.com http://www.williams-syndrome.org

48223 Chesterfield 16647 Chandler Rd. 2845 Crooks Rd. 3133 Orchard Vista Dr. SE 815 Terminal Rd.

Canton, 48187 East Lansing, 48823 Rochester Hills, 48309 Grand Rapids, 49546 Lansing, 48906

734 536-1602 517 203-4744 248 829-8292 616 234-5586 517 703-1110

http://www.wizardmed.com http://www.workingbugs.com http://www.firsttoserve.com http://www.xbtransmed.com http://www.xgsciences.com

5210 S. State Rd. 4300 44th St. SE 7171 First St. 7300 Whitmore Lake Rd. 4717 Campus Dr., Ste. 100

Ann Arbor, 48108 Grand Rapids, 49512 West Bloomfield, 48324 Brighton, 48116 Kalamazoo, 49008

800 709-6726 616 257-2203 248 858-2606 810 231-6600 312 997-2150

http://www.xorantech.com http://www.xrite.com http://www.yoursurgery.com http://www.zdr.com http://www.zusyn.com

Wizard Med LLC Working Bugs, LLC Wright & Filippis, Inc. XB Transmed Solutions XG Sciences, Inc.

Xoran Technologies, Inc. X-Rite YourSurgery.com ZDR, Inc. zuSyn

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